JPH04198123A - Amine deodorizing composition and deodorizing method - Google Patents

Abstract

PURPOSE: To obtain an amine-deodorizing composition that contains a specific primary amine and a topical carrier, is suitable for application to clothes which are put on skin or near skin and can inhibit the not-microbial, unpleasant smell accompanied by perspiration. CONSTITUTION: This deodorant composition comprises (A) a primary amine selected from the group consisting of the compounds of formula I to formula V[R is formula VI (R<1> is H, OH, a 1-20C alkyl, OH-1-20C alkyl ether), CHR<2> CO2 H (R<2> is H, an aryl, a 1-20C alkyl), a 1-20C alkyl; R<3> is a 1-6C alkyl], preferably p-methylaniline, p-ethoxyaniline, phenylhydrazine, canaline, aminoacetic acid and (B) a topical carrier in the form of liquid, solid, cream, gel, lotion. The content of the component A is 0.01-20wt.%, particularly 0.5-20wt.%. The component A is preferably applied to skin, clothes or fabrics at a rate of 0.01-1.0mg/cm<2> .

Description

DETAILED DESCRIPTION OF THE INVENTION Technical Field The present invention relates to compositions and methods for treating or preventing malodor associated with human sweating.

BACKGROUND OF THE INVENTION A vast amount of chemical, medical and cosmetological literature has been published regarding the causes, effects and prevention of human sweating.

"Sweating" or "sweat" is commonly defined to include the excretion of sweat glands located in the dermis or subcutaneous tissue, known as ephrine sweat glands, which are distributed over most of the body's surface.

Although sweat serves an important function in cooling the body through its evaporation, the by-products resulting from its bacterial breakdown are malodorous and aesthetically unpleasant.

Malodor is particularly associated with sweat secreted in areas of the body where apocrine sweat glands are also found in addition to ephrine sweat glands.

The two main areas with apocrine sweat glands are the axillae and crotch. For example, J.Labows, et al.

”Perspectives on Axillary
0dor” (perspectives on axillary odor), 34.J, So
c, Cosmetic Chemists, 193-2
02 (1982) and P. Jackman, “Body
0dor-The Role of Skin Bac
teria” (body odor – role of skin bacteria), 1°・Sem
Jnars in Dermatology, 143-
148 (1982).

Various bacteria are involved in the generation of axillary odor, and the main bacteria responsible for such malodor are Gram-positive bacterial flora naturally found in the axilla, such as Corynebacterium.
ria) and Propionibacteria (Propioni
diphtheritoids such as Bacteria and Gram-positive cocci such as Staphylococcus and Micrococcus.

Various compositions have been developed and described in the literature for controlling or eliminating aesthetic problems associated with sweating.

For example, S., PIehner, “AntiperSp
irantSanclDeodorants” (antiperspirants and deodorants), 2, Cosmetics
.

5science and Technology, 37
3-418 (M, Balsam and E, Sagari
ed., 1972). Such compositions are commonly classified as antiperspirants that help stop or reduce sweat flow, fragrances that mask unpleasant odors caused by sweat, and deodorants that stop or reduce the production of malodorants in sweat. I can do it. Deodorizing compositions are preferred by many consumers for a variety of reasons.

For example, some individuals are unable to use commercial antiperspirant products due to sensitivity to the astringents typically used in these products.

Deodorizing compositions have been primarily conceived in the art for their role in halting or reducing the formation of bacterial byproducts in perspiration. This has been done through the use of antimicrobial agents that attack the bacteria responsible for producing malodorous byproducts.

Although these antimicrobial deodorizers were effective in reducing malodors, they did not completely eliminate the formation of malodor conditions. Therefore, it would be desirable to provide a deodorizing composition that can further reduce malodors.

In addition, it is desirable to reduce malodor as soon as it forms. In some cases, malodors remain even after washing, for example in the armpit and crotch areas or in the armpit and crotch areas of clothing. Classically, already formed malodors have been masked by fragrances.

It would be desirable to provide improved methods and compositions for reducing malodors that remain after washing people or clothing. 198
In one approach, described in PCT International Patent Application No. WO 37/4341, published July 30, 2007, axillary malodor is treated with cupric sulfate, silver sulfate, potassium permanganate, and potassium chloride. diiron, sodium hydroxide,
Neutralization is disclosed by the use of protein silver, sodium hypochlorite, zinc sulfate or copper gluconate. However, it would be desirable to provide alternative techniques for neutralizing malodors.

It is an object of the present invention to provide a composition effective in suppressing non-microbial malodor of human sweat. Another object of the present invention is to provide an effective method for suppressing non-microbial malodor of human sweat.

SUMMARY OF THE INVENTION The present invention provides a deodorizing composition for application to clothing worn on or near the skin for suppressing malodor caused by perspiration, which contains a safe and effective amount of Amine compound: RC(0)R”NNH2C In the above formula, R is φ) R1(R
1 is selected from the group consisting of hydrogen, hydroxy, C1-C2o straight-chain or branched alkyl and C1-C2o straight-chain or branched alkyl ether of hydroxy), -C
HR2C0, HCR2 are hydrogen, aryl and C1-C2
(selected from the group consisting of 0 straight chain or branched chain alkyl)
and C2o straight or branched chain alkyl; R is C1-C6 alkyl] and a topical carrier.

Also provided is a method of suppressing sweat malodor by topically applying a safe and effective amount of a primary amine compound or composition of the present invention to the skin of the axilla or crotch area.

DETAILED DESCRIPTION OF THE INVENTION It has been suggested that malodor formation and neutralization involve more than one mechanism, but such mechanisms are not completely understood. The inventors have demonstrated that even when sweat from the axillary or groin regions of humans is disinfected, leaving virtually no viable bacteria that produce malodorous bacterial by-products,
Sweating also produces an aesthetically unpleasant odor when the scales are examined. Such malodors are hereinafter referred to as "non-microbial malodors."

The present inventors have discovered that the human ephrin sweat glands normally secrete
It was investigated that certain vitamin B6 compounds react with apocrine sweat gland secretions to form non-microbial malodors. The inventors have further determined that deodorizing compositions containing certain primary amine compounds are highly effective in reducing such non-microbial malodors in human sweat. These compositions are particularly useful in controlling malodors associated with sweating, both apocrine and ephrin.

Additionally, such compositions are effective in preventing the formation of non-microbial malodors.

It has been discovered that the primary amine compositions of the present invention are highly effective in inhibiting the development of non-microbial malodor conditions of perspiration and further deodorizing malodorous perspiration or preventing malodor formation in perspiration. Non-microbial malodor increases over time, especially when sweat rates are high and times between washes are long. The concentration of non-microbial malodor precursors on the skin is thought to increase as more sweat is secreted and as the aqueous component of already secreted sweat evaporates, thus increasing the formation of recognizable non-microbial malodors. . Without wishing to be bound by any theory, it is believed that primary amines react with the aldehyde form of vitamin B6 (PLP) by acting as strong nucleophiles.

The amines react with aldehyde groups via a Schiff base reaction, changing the PLP molecule and preventing it from mixing with other compounds in sweat that normally form malodors.

The occurrence of such malodor conditions from non-microbial sources is substantially reduced by the use of the primary amine compounds and compositions of the present invention.

The composition of the present invention contains as essential ingredients a primary amine compound as a deodorizing agent that suppresses non-microbial malodor and a compatible carrier. As used herein, "suppressing non-microbial malodors" means reducing already formed non-microbial malodors to a level that is less perceptible to the human sense of smell and/or inhibiting the development of non-microbial malodors. . As used herein, "compatible" means that none of the components of the carrier react with the primary amine compound in such a way that the ability of the composition to inhibit non-microbial malodors is substantially impaired. do.

As used herein, the term "alkyl" refers to a straight or branched chain, substituted or unsubstituted, saturated, -unsaturated (i.e., one double or triple bond in the chain) or polyunsaturated. (e.g., two or more double bonds in the chain; two or more triple bonds in the chain; one or more double bonds and one or more triple bonds in the chain). As used herein, a saturated alkyl group is referred to as an "alkani/b" and an unsaturated alkyl group with a double bond in the chain is referred to as an "alkeninopi", an unsaturated alkyl group with a triple bond in the chain. The base is “
The term "short chain alkyl" as used herein means an alkyl having from 1 to about 6 carbon atoms in the chain.

The term "hydroxy alkyl ether" as used herein means an alkyl ether having about 1 to about 20 carbons in the chain. As used herein, the term "short chain alkyl ether of hydroxy" means an alkyl ether with an alkyl having from about 1 to about 6 carbon atoms in the chain.

The term "aryl" as used herein refers to a substituted or unsubstituted aryl group.

“Substituted aryl ° means an aryl group having a substituent on the aryl ring. Examples of aryl include phenyl,
Naphthyl and substituted phenyl or naphthyl.

The term "substituted 2" as used herein means - or polysubstitution, especially -, di- or tri-substitution.

Examples of substituents include halogen (in particular fluorine, chlorine or bromine), alkyl, hydroxy, amino, aryl (
In particular, phenyl or naphthyl), carboxylate, nitro, -CF3 and =OR (R4 is about 1 to about 3 carbon atoms)
(particularly methoxy and nidoxy). The alkyl substituent is preferably C
1-C, s alkyl, more preferably methyl or ethyl.

The deodorizer of the present invention is a primary amine compound having the following formula: % RC(0)R3NNH.

In the above formula, R is XφΣR1 (R1 is hydrogen, hydroxy, C
selected from the group consisting of 1-C2o straight or branched alkyl and human (R is selected from the group consisting of hydrogen, aryl and C1-C2o straight or branched alkyl) and C1-C20 straight or branched alkyl R is C1-C
6 alkyl.

When R is straight-chain or branched alkyl, R is preferably selected from the group consisting of C1-C6 straight-chain or branched alkyl, more preferably C1-C6 straight-chain or branched alkenyl or alkanyl.

Preferred R is selected from the group consisting of Cl-C20 straight chain alkyl, more preferred R is C1-C20 straight chain alkenyl or alkanyl, even more preferred R is C1-C20 straight chain alkenyl or alkanyl.
It is a C6 straight chain alkanyl.

When R is XφXR, R1 is hydroxy, C1-C
2o Straight or branched alkyl and hydroxy C1-C
Preferably, it is selected from the group consisting of 2o linear or branched alkyl ethers. More preferably, R1 is selected from the group consisting of hydroxy, short chain alkyl and short chain alkyl ether of hydroxy. It is even more preferred that R1 is selected from the group consisting of hydroxy, short chain alkanyl or alkenyl and short chain alkanyl or alkenyl ethers of hydroxy. Preferred short chain alkanyls for R1 include methyl, ethyl and propyl;
The most preferred short chain alkanyl is methyl. Preferred short chain alkyl ethers of hydroxy for R1 include methoxy, ethoxy and propoxy, with the most preferred short chain alkyl ether of hydroxy being methoxy.

When R is -CHR"C02H, preferred R- is selected from the group consisting of aryl and C1-C20 straight chain or branched alkyl. More preferred R- is substituted or unsubstituted phenyl and C1-C2o straight chain or Selected from the group consisting of branched alkanyl or alkenyl, even more preferably R- is selected from the group consisting of unsubstituted phenyl, Cl-C10 straight-chain or branched alkenyl and C1-C20 straight-chain or branched alkanyl, and even more Preferred R is C1
-C6 or C14-C20 straight chain or branched alkanyl, even more preferably R is C1-C6 straight chain or branched alkanyl.

R3 is c-c alkyl, preferably cl-C6
alkanyl or alkenyl, more preferably cl-C3
Alkanyl, most preferably C1-C5 unsubstituted alkanyl.

Preferred deodorizing agents used in the compositions of the present invention include:
For example, p-methylaniline, p-ethylaniline, p-
Propylaniline, p-n-butylaniline, p-t
ert-butylaniline, p-methoxyaniline, p-
Ethoxyaniline, p-propoxyaniline, p-t
There are ert-butoxyaniline and p-n-butoxyaniline. Additionally, preferred deodorizing agents include, for example, phenylhydrazine, canalin, and aminoacetic acid. More preferred deodorizing agents are p-methoxyaniline or p-methylaniline.

The primary amine compound applicable to the present invention is manufactured by Aldrich Chemical Co.
company) [Milwaukee, Rice Consin]
It can be obtained commercially from industrial chemical sources such as.

The primary amine deodorizers of the present invention are substantially non-malodorous under normal conditions of use.

The -R group of the primary amine deodorizer does not react with compounds normally found in sweat products such that the resulting compound is appreciably malodorous, or the primary amine compound does not react with vitamin B6 aldehyde in sweat products. Preferably, it is restricted so as not to react with the compound. However, it will be appreciated that fragrances may also be added to the composition as an optional ingredient to mask the slight malodor of the primary amine compound and its reaction products.

The compositions of the present invention, when used as intended, contain a safe and effective amount of a primary amine compound. As used herein, a "safe and effective amount" is an amount that is effective in eliminating or substantially reducing non-microbial malodor and is safe for the intended use with a reasonable benefit/risk ratio.

A9 Topical Compositions One aspect of the present invention is a deodorizing composition comprising a primary amine compound and a topical carrier. The deodorizing compositions of the present invention containing primary amine compounds can be a variety of products that are applied topically to the skin or applied to clothing worn close to the skin in normal use. Compositions formulated for topical application to the skin or manufactured for deposition on clothing and designed to remain deposited, at least initially, as the clothing is worn, contain a safe and effective amount of a primary amine compound and Includes a topical carrier for depositing or releasing the deodorant. As used herein, "applied to the skin" and "application to the skin" refer to compositions in which the deodorant is not typically deposited, such as skin cleaning compositions that are typically washed off after use. (described in more detail below) and its deposition on the skin such that the deodorant remains on the skin even after treatment of the skin with the composition.

The topical carrier for the deodorizing compositions of the present invention is in the form of a liquid, solid, cream, gel, lotion or other form, preferably formulated to be capable of depositing the deodorant on the skin or clothing. As used herein, "deposited" and "deposited" of a deodorizing agent on the skin refer to depositing the deodorizing agent on the skin after typical use of the deodorizing composition, including any conventional post-deodorizing composition application steps. The deodorizing composition is applied to the skin such that the deodorizing composition remains on the skin.Such topical carriers include, but are not limited to, creams, sticks,
Roll-on and spray liquids (including aerosols)
Conventional deodorizing compositions such as Niskin lotions, skin conditioners, sunscreens and windscreens, body lotions such as sunscreen lotions and oils, creams and oils: such as bar soaps, liquid soaps and cleaning gels. There are carriers that are prescribed as skin cleansing products.

Typically, the topical deodorizing compositions of the present invention will contain from about 0.01 to
It contains about 20%, preferably about 0.05% to about 5%, more preferably about 0.5% to about 296% rice amine deodorizer.

Preferred deodorizing compositions of the present invention are conventional deodorizing compositions, including antiperspirant/deodorizing compositions formulated for topical application to the axillary region of the body or for application to the crotch region. The specific ingredients contained in the deodorizing compositions of the present invention will depend on the specific mode of application desired. These methods of application and the ingredients used in such compositions are well known in the art. A number of such compositions have been described by S. Plechner, +^ntip
erspiranLs and Deodorants”
(antiperspirant and deodorant), 2. Cosmetics.

5cjence and Technology, 37
3-418 (M, Balsam and E, Sagari
ed, 1972), which is incorporated herein by reference.

The topical carrier for deodorizing compositions primarily formulated for the deposition of rice amine deodorants onto the skin of the axillary area for malodor control preferably contains no more than about 5% water, more preferably no more than about 2% water. It is hydrophobic so that water, most preferably essentially 0% water, is present. Other compositions may contain large amounts of water, and the presence of water is not expected to affect the efficacy of the rice amine deodorizer.

Topical carriers useful for depositing rice amine deodorants on the skin in the form of creams, ointments, lotions, oil-in-water and water-in-oil emulsions are known in the art and are known in the art, for example Water-in-oil emulsions disclosed in U.S. Patent No. M4,254°105 issued to Fakuda et al.
European patent application M281,394 of eroa et al.
There are also three-phase emulsion carrier systems, such as the silicone oil-in-water emulsions disclosed in 2003 (incorporated herein by reference).

1. Liquid compositions useful in this invention, such as roll-ons, sprays, and aerosols, preferably contain a liquid emollient as all or a substantial portion of the topical carrier. Such compositions are suitable for delivery from conventional roll-on, spray and aerosol containers (respectively) known in the art. Such emollients include fatty acid and fatty alcohol esters, water-insoluble ethers and alcohols, polyorganosilicones, and mixtures thereof. Polyorganosilicone is one of the preferred emollients useful herein. Liquid topical carriers are disclosed in the following patent specification, which is incorporated herein by reference: U.S. Pat. No. 4,053,85 issued to Pader et al.
No. 1, December 27, 1977 Miles, Jr.
U.S. Patent No. 4,065,564, 19, issued to et al.
U.S. Pat. No. 4,073,880 issued to Padcr et al. on Feb. 14, 1978; U.S. Pat. No. 4,278.655 issued to Ela+i on July 14, 1981.
Issue: EI+Il published on October 24, 1979
British Patent Application Box 2,018,590 of i et al.; and 19
Beckmeyer et al., European Patent Application Box 28,853, published July 11, 1984.

The liquid deodorizing compositions of the present invention may also contain alcohols and/or polyols as a substantial component of the topical carrier. Alcohols useful herein include ethanol, propatool, isopropanol and mixtures thereof. Polyols useful here include glycols such as propylene glycol.

The liquid composition may also contain fillers to modify the physical and/or cosmetic characteristics of the composition. Such fillers are typically present at levels of about 1 to about 898. Bulking agents useful herein include talc, colloidal silica, clays, and mixtures thereof.

2. Aerosols The aerosol compositions of the present invention contain one or more volatile substances, i.e. herein "
The aerosol propellants useful herein typically have a boiling point in the range of about -45°C to about 5°C. The rapid boiling of the aerosol propellant upon exiting the aerosol container serves to atomize the other components of the aerosol composition.

Aerosol propellants useful herein include those well known in the art. Suitable aerosol propellants include chemically inert hydrocarbons, such as propane, n-butane, isobutane, cyclopropane and mixtures thereof, as well as halogenated hydrocarbons, such as dichlorodifluoromethane (propellant). 12), 1. ．． 1-dichloro-1,
1,2,2-tetrafluoroethane (propellant 114),
1-chloro-1,1-difluoro-2,2,2-trifluoroethane (propellant 115), 1-chloro-1゜1-
These include difluoroethylene (propellant 142B), 1-difluoroethane (propellant 152A), monochlorodifluoromethane and mixtures thereof. Isobutane, used alone or mixed with other hydrocarbons, is preferred for the aerosol compositions of the invention.

3. Deodorizing Sticks The solid compositions of the present invention are typically prepared in the form of sticks known in the art, typically containing a liquid base material and a coagulant.

Contains a solid agent. These deodorizing sticks are commonly described as either gel sticks or wax sticks, depending on the specific liquid base material and coagulant used. Generally, the liquid-based material will be about 10 to about 9
Present at a level of 7%. Coagulants are typically present at levels of about 1% to about 7%.

As will be apparent to those skilled in the art, the choice of the particular liquid base material and the appropriate coagulant will vary depending on the particular type and rheology of the deodorizing stick desired. Various liquid base materials and coagulants useful herein, as well as sticks made from these materials, are described in the following documents, all of which are incorporated herein by reference:
S, PIechner, + Antiperspiran
ts and Deodorants”, 2. CosmeLics, 5c1ence a
ndTechnology, 373-416 (M,B
a1saa+ and E, Sagarined,, 197
2): C, Fax, “Gel and 5ticks
Review and Update” (Considerations and latest information on gels and sticks), 99.Cos+gctic
s & Toiletries, 19-52 (1984
) HN, Ger5a, -Formulation of
5tick Antiperspirants and
Dcoc! orants” (stick antiperspirant and deodorant formulation), 99.Cosmetics & Toil
etries, 55-99 (1984); and -G.
els andSlicks Fora+ulary-
(gel and stick formulation), 99°CosmeLic
s & Toiletries, 77-87 (1984
).

The liquid base materials used in wax deodorant sticks usually also function as emollients, improving the cosmetic acceptability of the deodorant stick. Such emollients include fatty acid and fatty alcohol esters, water-insoluble ethers and alcohols, polyorganosiloxanes, and mixtures thereof. Polyorganosiloxanes are one of the preferred liquid base materials useful in the wax deodorizing sticks of the present invention.

Coagulants useful in the wax deodorizing sticks of the present invention are wax materials, typically incorporated at levels of about 5 to about 50%. Such wax materials useful herein are high melting waxes having melting points of about 65-102°C. Low melting waxes having melting points of about 37-75°C are also preferred. Such low melting waxes include fatty acids, fatty alcohols, fatty acid esters, fatty acid amides and mixtures thereof. Stearyl alcohol, cetyl alcohol and mixtures thereof are also particularly preferred wax materials useful in the deodorizing stick compositions of the present invention.

Liquid base materials and coagulants among those useful in the wax-type deodorizing sticks of the present invention are disclosed in the following U.S. patents, which are incorporated herein by reference:
U.S. Pat. No. 4,049,792 issued to Elsnau on September 20, 1977; U.S. Pat. No. 4,151.272 issued to GearY et al. on April 24, 1979; U.S. Patent No. 4,299.432, issued to Geria on July 28, 1981;
, No. 280,994; dated November 21, 1978
U.S. Pat. No. 4,126,679 issued to vy et al.;
and May European Patent Application No. 117,070, published August 29, 1984.

The gel deodorizing stick of the present invention comprises a liquid-based material selected to also exhibit desirable cosmetic properties, such as emollient properties and/or a cooling sensation when applied to the skin. Liquid base materials useful in such gel sticks include water, lower-hydric alcohols, polyhydric alcohols, and mixtures thereof. Such substances include ethanol, isopropanol, n-propanol, n-propanol,
-Butanol, isobutanol, t-butanol, ethylene glycol, propylene glycol, trimethylene glycol, glycerin, 1,3-butanediol, 1
, 4-butanediol and mixtures thereof. Ethanol, propylene glycol and mixtures thereof are preferred liquid base materials for the gel sticks of the present invention.

Coagulating agents useful in the gel deodorizing sticks of the present invention are generally surface-active compounds that solidify or coagulate the liquid-based material into a gel to form a network. Such coagulants typically include soaps, higher fatty acid amides of alkylamines, benzylidene sorbitol, propionates and lactates, waxes, and mixtures thereof. The preferred coagulant for the gel deodorizing stick of the present invention is nonionic in nature. A preferred coagulant useful in the gel deodorizing sticks of the present invention is benzylidene sorbitol, particularly dibenzaldehyde monosorbitol acetal.

Such materials are available from a variety of sources, such as Gell A11-Do (Nippon Kagaku (N.
ew Japan Chemical Company
.

Ltd.] and Millithix
o) Millikan Chemical, Div., of C. Milliken & Co.
ision or Milliken & Co[1pan
It is commercially available as [manufactured by Y)]. Among those useful in the gel-type deodorizing sticks of the present invention, liquid base materials and coagulants are disclosed in the following patent specification, all of which are incorporated herein by reference: 5taler, August 18, 1959. Issued U.S. Patent No. 2,900,3
No. 06; U.S. Pat. No. 3,255,082 issued to Barton on June 7, 1966; U.S. Pat.
137° No. 306; Roeh dated May 15, 1979.
U.S. Pat. No. 4,154,816 issued to Yuhas et al.; U.S. Pat.
U.S. Patent No. 4,346, issued to Roeh l.
No. 079, U.S. Pat. No. 4,383,988 issued to Teng et al. May 17, 1983;
U.S. Patent No. 4,504,465 issued to Saa+pson et al.
No. 4,816,261 issued to Lucbbe et al. in 1989.

A preferred gel stick formulated with benzylidene sorbitol and cetyl alcohol is disclosed in U.S. Pat. No. 4.743, issued May 10, 1988 to Medal.
．． No. 444, incorporated herein by reference.

The deodorizing sticks of the invention, especially wax type deodorizing sticks, may contain inert filler substances. Such materials include talc, colloidal silica [e.g., Cabot Corporation (Cabot Corporation 1o
n) Sales of Cab-0-3il
o) ), clays (eg bentonite) and mixtures thereof. Such filler substances were introduced in 1978
U.S. Pat. No. 4,126,679 issued to Davy et al. on November 21, 1984 (incorporated herein by reference) and May's European Patent Application published on August 29, 1984. No. 117,070, incorporated herein by reference.

Deodorizing compositions of the invention that are applied topically to the skin may, in addition to the rice amine deodorizers of the invention, also contain optional ingredients that function as additional "active" ingredients when deposited on the skin. However, it is preferred that such additional active ingredients do not substantially interfere with the deodorizing activity of the rice amine. Active ingredients include, but are not limited to, antimicrobial agents, such as bactericides and fungicides, and other deodorants, such as antiperspirants.

The active ingredient must be stable in the formulation of the composition. Preferably, a "safe and effective amount" of the active ingredient is used. Among those useful in the present invention are various active ingredients:
No. 4,226,889 issued to Yuhas on Oct. 7, 980, incorporated herein by reference.

Preferred antiperspirant materials useful in the deodorizing compositions of the present invention include aluminum and zirconium salts such as aluminum halide, aluminum hydroxyhalide, oxidized zirconyl halide, zirconyl hydroxyhalide, and mixtures thereof. Among those useful herein are antiperspirants as described in European Patent Application No. 28,853, published July 11, 1984, to Beckmeyer et al., incorporated herein by reference. ing. Such materials are typically included at a level of about 15% to about 40%, based on the total weight of the composition.

Other optional antiperspirants include U.S. Pat. No. 4,226.8 issued to Packman on October 7, 1980.
Specification No. 50 and Pacl dated November 18, 1980
ethanolamines, ethylenediamines, alkylamines, phenothiazines and piperazines, as described in U.S. Pat. No. 4,234.566 issued to Van. or their pharmaceutically acceptable salts. Still other optional antiperspirants include MacMi fan, April 4, 1967.
U.S. Patent No. 3,312,709, issued June 20, 1967; U.S. Patent No. 3,326,768 issued June 20, 1967;
No. 3,767,786, issued October 23, 1973, to MaeMi I Ian; and US Pat. No. 3,624,200, issued November 1971 to Moffett (all There are various anticholinergic agents, such as the belladonna alkaloids scopolamine and esters of atropine, which are described in (incorporated herein by reference).

As will be appreciated by those skilled in the art, certain antiperspirant substances described above may be ineffective in or destabilize the compositions of the present invention. Accordingly, the compositions of the present invention may contain a buffering agent to maintain a pH of at least about 6.0 in the composition. Such buffers were introduced in 1979.
No. 4,154°816 issued to Roehl et al., May 15, 1982; August 24, 1982.
U.S. Patent No. 4,346 issued to Roeh I on
, No. 079; and 5c dated May 21, 1985.
U.S. Pat. No. 4,518.5 issued to Halper et al.
No. 82, all of which are incorporated herein by reference.

Some preferred compositions of the present invention also contain safe and effective amounts of deodorizers other than rice amine deodorizers, such as antimicrobial agents (eg, bactericides and fungicides) or mixtures thereof.

Such other deodorants (by weight of the composition) may contain from about 0.1 to
Usually present at a level of 10%. Other suitable deodorants include cetyltrimethylammonium bromide, cetylpyridinium chloride, benzethonium chloride, diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride, sodium N-laurylsarcosine, sodium N-polymethylsarcosine, lauroylsarcosine, N-myristoyl. There are bacteriostatic quaternary ammonium compounds such as glycine, N-lauroylsarcosine potassium, stearyltrimethylammonium chloride, and mixtures thereof. Other suitable deodorizers include 2
゜4.4-1 Lichloro 2-hydroquine diphenyl ether, zinc pyrithione (ZPT) and sodium bicarbonate. Other particularly preferred deodorizers include 197
Diaminoalkylamides such as L-lysine hexadecylamide disclosed in U.S. Pat. There is.

Other optional components of the deodorizing composition of the present invention include fragrances, pigments, dyes, colorants, and ultraviolet absorbers.

The deodorizing compositions of the present invention are manufactured by various techniques well known in the art. For example, such techniques for producing solid deodorizing compositions are described by °'Gels and SticksFo.
rmulary” (gel and stick formulations), 99
゜Cosmetics & Toiletries, 7
7-87 (1984), which is incorporated herein by reference.

4. Creams, Ointments and Lotions The cream, ointment and lotion compositions of the present invention typically include one or more emollients as a component of the topical carrier. As used herein, "emollient" refers to substances used to prevent or reduce dryness and protect the skin. A variety of suitable emollients are known and can be used in the present invention. Sagarin, Co55eLies, 5cjenc, incorporated herein by reference.
e and Technology, 2ndEdit1
on, Vol. 1. pp. 32-43 (1972) contains various examples of suitable materials. Examples of useful emollient types include: hydrocarbon oils and waxes; silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane, water-soluble and alcohol-soluble silicone glycol copolymers; vegetable and animal fats, etc. triglyceride esters such as acetylated monoglycerides; ethoxylated glycerides such as ethoxylated glyceryl monostearate; alkyl esters of fatty acids having 10 to 2° carbon atoms; 10 to 2 carbon atoms;
Alkenyl ester of fatty acid with 0 white: 1 carbon atom
Fatty acids having from 0 to 20; fatty alcohols having from 10 to 20 carbon atoms; fatty alcohol esters; ether-esters such as ethoxylated fatty alcohol fatty acid esters; lanolin and derivatives: polyhydric alcohols and polyether derivatives; polyhydric alcohol esters ; wax esters such as beeswax, spermaceti, myristyl myristate, stearyl stearate; beeswax derivatives; vegetable waxes such as carnauba and candelilla waxes; phospholipids such as lecithin and derivatives; - cholesterol and cholesterol fatty acid esters Sterols like:
Amides such as fatty acid amides, ethoxylated fatty acid amides, solid fatty acid alkanolamides.

Particularly useful emollients that provide skin conditioning are glycerol, hexanetriol, butanetriol, lactic acid and its salts, urea, pyrrolidone carboxylic acid and its salts, amino acids, guanidine, diglycerol, and triglycerol.

The lotion of the present invention in solution form typically has a concentration of about 0.01
~ about 20%, preferably about 0.1 to about 5% rice amine deodorizer; about 1 to about 20%, preferably about 5 to about 10% emollient: about 50 to about 90%, preferably Contains about 60 to about 80% water.

Creams of the invention in solution form typically have a concentration of about 0.01 to
About 20%, preferably about 0.1 to about 5% rice amine deodorizer; about 5 to about 50%, preferably about 10 to about 20% emollient; about 45 to about 85%, preferably about Contains 50 to about 75% water.

The ointments of the present invention contain a single base of animal or vegetable oil or semi-solid hydrocarbon (oily). The ointment may also include an absorbent ointment base that absorbs water to form an emulsion. Examples of such ointment bases are anhydrous lanolin and hydrophilic petrolatum. Emulsion ointment bases may be oil-in-water or water-in-oil emulsions. Ointment carriers may also be water soluble. Examples of such ointment carriers include ingredients such as glycol ethers, propylene glycol, polyoxylstearates and polysorbates. Ointments typically contain about 2% to about 10% emollient and about 0.1% to about 296% thickening agent. A more detailed disclosure of thickening agents useful herein is provided by Segarin, Cosme
tics, 5science and Techno
Logy.

2nd Edition, Vol, I, pp, 72-7
3 (1972), which is incorporated herein by reference.

When the topical carrier of the present invention is formulated as an emulsion, typically about 1% to about 10%, preferably about 2% to about 5% of the carrier is an emulsifier.

The emulsifier may be nonionic, anionic or cationic. Suitable emulsifiers are e.g.
No. 3, issued to Dickert et al.
No. 755,560; U.S. Pat. No. 4,421.76 issued to Dixon et al. on December 20, 1983.
9 specification; and McCutcheon's, Dete.
rgents and emulsifiers.

North American Edition, pa.
ges 317-324 (198B), the disclosures of which are incorporated herein by reference. Preferred emulsifiers are anionic or nonionic, although other types can also be used.

Single emulsion skin care formulations such as oil-in-water and water-in-oil lotions and creams are well known in the cosmetic industry and are also useful in the present invention. Multiphase emulsion compositions such as the water-in-oil-in-water type disclosed in U.S. Pat. are also useful in the present invention. Generally, such single or multiphase emulsions contain water, emollients and emulsifiers as essential ingredients.

Also useful in the present invention are three-phase emulsion carriers containing the silicone oil-in-water emulsion compositions disclosed in European Patent Application Box 281,394 (noted above). More specifically, such a three-phase emulsion carrier system comprises: a) a silicone liquid continuous phase consisting essentially of at least one liquid organopolysiloxane;
b) from about 30 to about 80% by weight (in the vehicle) of an aqueous discontinuous phase comprising an oil-in-water emulsion of a cosmetically acceptable oily liquid non-particulate phase dispersed in a liquid phase; and C) An effective dispersion of about 0.5 to about 5 weight percent dimethicone copolyol (in the vehicle) to disperse (b) in (a).

Another emulsion carrier useful in the compositions of the present invention is a microemulsion carrier.

Such carriers include about 9% to about 15% squalane, about 25% to about 40% silicone oil, about 8% to about 20% fatty alcohol, and about 15% to about 30% polyoxyethylene sorbitan monofatty acid [trade name Tween (Tνeeno)
] or other nonionic substances and about 7 to about 20%
Contains water.

Lotions and creams can be formulated as emulsions and solutions. Typically, such lotions in emulsion form contain from about 0.01 to about 20%, preferably from about 0.1 to about 5% rice amine deodorizer; from about 1 to about 2%.
0%, preferably about 5 to about 10% emollient; about 25
to about 75%, preferably about 45 to about 95% water; and about 1 to about 10%, preferably about 2 to about 5% emulsifier. Such creams in emulsion form typically contain from about 0.01% to about 20%, preferably from about 0.61% to about 5% rice amine deodorizer; from about 1% to about 20%, preferably from about 5% to about 10%. about 20 to about 80%, preferably about 30 to about 70% water; and about 1 to about 10%, preferably about 2 to about 5% emulsifier.

5. Skin Cleansing In addition to the deodorizing composition described above, the deodorizing composition of the present invention includes a skin cleansing deodorizing composition, which contains a primary amine compound and a safe and effective amount of surfactant for topical application to human skin. and a topical carrier containing. The term "a safe and effective amount of a surfactant for topical application to human skin" refers to a surfactant that is not only an effective skin cleanser, but also can be used without undue toxicity, irritation, allergic reactions, etc. The skin cleansing deodorizing composition of the present invention preferably contains from about 0.01% to about 20% rice amine deodorizing agent and from about 1% to about 90%, preferably from about 50% to about 9090% surfactant for topical application to human skin. What does it contain?

The physical form of the skin cleansing deodorizing composition is not important. The composition can be formulated, for example, as a cosmetic solid, liquid, paste or mousse. The cosmetic solid body is
This is most preferred as it is the most commonly used form of cleansing agent for cleaning the skin.

Those skilled in the art will appreciate that active ingredients applied to the skin from skin cleansing compositions may not typically be significantly deposited on the skin due to factors such as washing after application of such products. Probably. Even if no significant deposition of rice amines on the skin is achieved, the composition is still highly effective in controlling non-microbial malodor already formed in the axillary or groin area. Non-microbial malodor control when combined with skin cleansing compositions is beneficial since malodorous skin conditions persist even after the affected axillary and crotch areas have been cleansed with conventional skin cleansing compositions. It shows a particularly large effect.

A safe and effective amount of surfactants compatible with the rice amine deodorizer may also be used in the compositions of the present invention, such as surfactants selected from anionic, nonionic, zwitterionic, amphoteric, ampholyte surfactants and mixtures of these surfactants. It can be used in things. Such surfactants are well known to those skilled in the detergent industry.

Suitable surfactants include, for example, McCutcheon's
.

Detergents and Emuls1f'1e
rs, North AIIericanEd,, pag
es 317-324 (1986), which is incorporated herein by reference. It is not believed that the particular surfactant is important in obtaining the antimicrobial malodor effect of the present invention.

The skin cleansing and deodorizing composition of the present invention comprises the above substances,
Antibacterial and fungicidal agents further comprising the materials described in U.S. Pat. The above materials may also include mineral oil, paraffin wax having a melting point of about 100 to about 170, fatty sorbitan esters (herein incorporated by reference).
No. 3,988,255 issued Oct. 26, 1976), lanolin and lanolin derivatives, esters such as isopropyl myristate, triglycerides such as coconut ura or hydrogenated tallow. Emollients; free fatty acids such as coconut oil fatty acids, preferably at a level of about 10% or less to improve the volume and quality (creaminess) of the lather produced by the composition; fragrances, dyes, pigments, polymers. Skin sensitizers [for example, Hoechst Celanese (t(oechst C)
Jaguar manufactured by e1anese Corp.
ar) Cationic quaternized guar gum such as C-14-S], humectants, thickeners, preservatives, alkali agents, propoxylated glycerol derivatives skin conditioning agents or other cosmetic adjuvants. It may optionally contain materials conventionally used in skin cleansing compositions, including ingredients at their art-established levels.

Skin cleansing compositions formulated as cosmetic bar soaps usually contain from about 50 to about 90% surfactant. Moisture is usually present at a level of about 5% to about 20%. Skin cleansing compositions formulated as liquids typically contain about 10 to
Contains about 30% surfactant and about 60 to about 90% water. Skin cleansing compositions formulated as pastes usually contain about 20 to about 60% surfactant and about 30 to about 50% water. Pastes and liquids usually also contain organic thickeners such as natural rubbers and polymers.

An example of a soap-based cosmetic bar composition is U.S. Patent No. 3.567 issued to Megson et al. on April 27, 1971.
．． No. 749, which is incorporated herein by reference. Examples of synthetic base cosmetic solids that can be used in preparing the compositions of the invention include: June 6, 1961
No. 2, issued to Lundberg et al.
No. 987,484, which is incorporated herein by reference. Other examples of soap/synthetic based cosmetic solids are given in Chaffe, December 25, 1962.
No. 3,070,547 issued to E. and U.S. Pat. and is incorporated herein as such. Examples of soap-based liquid cleansing compositions that can be used in preparing the liquid compositions of the present invention include St.
U.S. Patent No. 4,310,433 issued to i ros
No. 2, which is incorporated herein by reference.

Examples of synthetic-based liquid cleansing compositions that can be used in preparing the compositions of the present invention include
U.S. Patent No. 4,338.2 issued to t tros.
No. 11, which is incorporated herein by reference. Paste compositions are prepared by appropriate reduction of the level of water in the compositions of US Pat. Nos. 4,310,433 and 4,338,211, which are incorporated herein by reference. Examples of ultra-mild skin cleansing compositions that can be used to prepare compositions of the present invention are found in U.S. Pat. No. 4,673,525, issued June 16, 1987, to Small et al. , which is incorporated herein by reference. Examples of skin cleansing mousse compositions containing ethoxylated nonionic and wholly or partially esterified polyol nonionic surfactants and also having skin conditioning ingredients such as emollients and skin moisturizers are published on November 14, 1987. No. 4,708,813, issued to 5NYDER, which is incorporated herein by reference. In addition to disclosing examples of skin cleansing compositions of the present invention, the above-incorporated patent specifications disclose a variety of skin cleansing compositions that can be used in the compositions of the present invention, including both soap-based and detergent-based surfactants. Surfactants are also disclosed. The skin cleansing deodorizing composition of the present invention is produced by blending a rice amine deodorizing agent into the same composition as above.

B. Laundry Product Compositions Another aspect of the present invention relates to laundry product compositions comprising the rice amine deodorizers and laundry product carriers of the present invention.

Carriers for laundry products can be in liquid, granular or solid form and contain liquid and granular detergents and wash additive, rinse additive and dryer additive substrates, which may contain other additives such as fabric conditioning and/or detergent ingredients. It may also contain the following ingredients. Laundry product compositions include primary amine deodorizers that deodorize and wash or rinse away clothing (odor removal) or are deposited on clothing to control non-microbial odors (odor prevention) during the washing step. Therefore, it is prescribed to remain in place either. The laundry product compositions of the present invention are believed to be particularly beneficial in reducing non-microbial malodor substances adsorbed onto fabrics.

Typically, such laundry product compositions contain about 0.001
Contains ~20% rice amine deodorizer.

Laundry product compositions formulated for odor removal preferably contain about 0.001% to about 1%, more preferably about 0.005%
to about 0.5%, even more preferably from about 0.01 to about 0.5%.
Contains 1% mono-amine deodorizer. Laundry product compositions formulated for odor control preferably contain from about 0.01 to about 10
%, more preferably from about 0.1 to about 5% of a monoamine deodorizer.

As used herein, "laundry product compositions" include compositions such as liquid and granular detergents, liquid and granular fabric conditioning, and washer or dryer additive substrates, which include fabric conditioning and/or detergent ingredients. It may also contain.

Such compositions include more of the amine agent of the present invention, but typically also include one or more of the following ingredients:

Cleaning Surfactant 2 The detergent composition of the present invention contains an organic surfactant ("surfactant") to provide the usual cleaning effects associated with the use of such products.

Detergent surfactants useful herein include the well-known synthetic anionic, nonionic, amphoteric and zwitterionic surfactants. Typical examples of these are alkylbenzene sulfonates,
Alkyl and alkyl ether sulfates, paraffin sulfonates, olefin sulfonates, amine oxides, α-sulfonates of fatty acids and fatty acid esters, alkyl glycosides, ethoxylated alcohols and ethoxylated alkyl phenols, etc., are well known in the detergent industry. Generally, such detersive surfactants have alkyl groups in the C9-c18 range, although anionic detersive surfactants can be used in the form of their sodium, potassium or triethanolammonium salts.

Standard texts such as McCutcheon's Index contain detailed lists of such typical detersive surfactants. C11-014 alkylbenzene sulfonates, C12-01g paraffin sulfonates, C12-018 alkyl sulfates and alkyl ether sulfates are particularly preferred in compositions of this type.

Water-soluble soaps, such as common sodium and potassium coconut or tallow soaps well known in the art, are also useful here.

Unsaturated soaps such as alkyl soaps may also be used, especially in liquid formulations. Saturated or unsaturated C9-C1B hydrocarbyl succinates are also effective.

with anionic substances such as alkylbenzene sulfonates, alkyl sulfates and paraffin sulfonates.
Mixtures with 9-C16 ethoxylated alcohol surfactants provide through-the-wash broad-spectrum soil and soil removal from fabrics.
h) Preferred for cleansing.

Combinations of anionic, cationic and nonionic surfactants can also commonly be used. Such combinations or combinations of anionic and nonionic surfactants alone are also preferred for liquid detergent compositions. Such surfactants are commonly used in acid form and are neutralized during the manufacture of liquid detergent compositions. Preferred anionic surfactants for liquid detergent compositions include linear alkylbenzene sulfonates, alkyl sulfates, and alkyl ethoxylated sulfates. Preferred nonionic surfactants include alkyl polyethoxylated alcohols.

Anionic surfactants are preferred for use as detersive surfactants in granular detergent compositions. Preferred anionic surfactants include linear alkylbenzene sulfonates and alkyl sulfates. Combinations of anionic and nonionic detersive surfactants are also particularly useful for granular detergent applications.

Detergent compositions typically contain from about 10 to about 60% water-soluble detersive surfactant. Suitable surfactant and detergent compositions are described in Laugh Li, December 30, 1975.
No. 3,929°678 issued to n et al. and U.S. Pat. Both are incorporated herein by reference.

Conventional builders: Builders used in the practice of this invention include various metal ion sequestrants such as amine chelators and phosphonate chelators, alkylene amino acids such as diethylenetriaminepentaacetic acid, ethylenediaminetetraphosphonic acid, etc. These include phosphonates and tripolyphosphates as well as "pyro" builders well known in the art. Importantly, a variety of non-phosphorous builders can be used. For example, but not limited to these, 1 to 10
μ Zeolite A (Zeolite A), 2. 2-
- oxodisuccinates, tartrate mono- and disuccinates, citrates, C8-014 hydrocarbyl succinates, sodium carbonate and mixtures thereof. Inorganic salts such as sodium sulfate may also be present. A list of builders useful herein can be found in the above-cited US Pat. No. 4,704,233.

Bleach: A variety of well-known bleaching agents (particularly fiber and fabric bleaches) are well known and can be used as components of carriers for laundry products. Sodium perborate and tetrahydrate are preferred for laundry products, but percarbonates and persulfates are also useful. Aqueous hypochlorite is also a routine additive in many laundry operations. As mentioned above,
Bleaching agents useful as components of the compositions of this invention are limited to those that are compatible with the rice amine compounds in the compositions.

Detergent adjuvant compositions can contain a variety of ingredients to aid their cleaning performance. For example, the laundry compositions preferably also contain enzymes to enhance their through-the-wash cleaning performance on various soils and soils. Amylase and protease enzymes suitable for detergent applications are well known in the art and in commercial liquid and granular detergents. Commercially available detergent enzymes (preferably a mixture of amylase and protease) are typically used in the present compositions at levels of 0.001 to 296 and higher.

Furthermore, in addition to the above ingredients, the compositions can also contain various other optional ingredients typically used in commercial products to provide aesthetic or additional product performance benefits. Typical ingredients include pH adjusters, fragrances, dyes, bleaches, fluorescent brighteners, polyester soil release agents, hydrotropes, gel control agents, freeze-thaw stabilizers, fungicides, preservatives, and foam control agents. , bleach accelerators, etc.

Fabric softeners, particularly clays and mixtures of clays with various amines and quaternary ammonium compounds, can all be used in the present compositions. Such matters are well known from the patent literature and from commercial practice.

The compositions are manufactured using conventional techniques well known to formulators of commercial detergent and bleach products.

Fabric conditioning agents, when present in laundry product compositions, typically range from about 1% to about 35%, preferably from about 6% to about 25% of the composition. The specific fabric conditioning agent utilized is not believed to be critical to the invention, and any fabric conditioning agent known in the art is believed to be applicable. These include, for example, 19
Quaternary ammonium fabric conditioners as disclosed in U.S. Pat. No. 3,936,537, issued to Bakervi IIe et al.
Tertiary amines as disclosed in UK Patent No. 1,514,276 to Kenyon, published June 14, 1978; assigned to Bayer, July 1977;
British Patent No. 1.077.103 published on the 26th of May
1,077.104 and U.S. patent application Ser. 5t as of December 13th
No. 4,062,647 issued to Orn et al. and British Patent No. 1, assigned to Procter & Gamble and published August 24, 1977
There are smectite type clay flexible systems such as those described in US Pat. No. 483.627.

Aqueous dispersions useful for direct application to clothing in aerosol form include primary amine deodorizers, about 0. 1-10% water,
From about 0.01 to about 5% of a suitable organic solvent and the balance a suitable propellant. Examples of such propellants are chlorinated, fluorinated and chlorofluorinated low molecular weight hydrocarbons. Nitrogen oxide, carbon dioxide, isobutane and propane can also be used as propellant gases. These propellants are used at levels sufficient to propel the contents of the container. Suitable organic materials useful as a solvent or part of a solvent system are: propylene glycol, polyethylene glycol (M, W, 200-600), polypropylene glycol (M, W, 425-2025), glycerin, Sorbitol esters, 1,2,6-hexandriol, diethyl tartrate, butanediol and mixtures thereof. The balance of the composition is a liquid carrier, preferably the carrier is water or a mixture of water and a -hydric alcohol.

Liquid fabric treatment compositions can be prepared in part by mixing amine deodorizers alone or with other ingredients in a solvent.

The deodorizer of the present invention can be added to the granule carrier by mixing the deodorant with the other composition components in solution before being spray-dried, and then spray-drying the mixture in a conventional manner. On the other hand, granular or powdered laundry product compositions may be prepared by tri-blending the deodorizer with other composition ingredients.

C1 Fabric Treatment Compositions Another aspect of the present invention is a fabric treatment composition comprising a partial amine agent of the present invention and a fabric treatment carrier for deposition onto clothing or fabrics worn close to the skin. Regarding. The "fabric processing carrier" used herein typically includes one or more of the following ingredients: a fluorescent brightener, a surfactant (preferably nonionic or anionic), or an organic ester.

It is believed that the fabric treatment composition can prevent or reduce the formation of non-microbial malodors due to axillary or crotch area stains absorbed into the garment. As a carrier for fabric treatment, the primary amine deodorizer may be deposited on the garment before washing or drying the garment, or the deodorant may be deposited on the garment before it is used or worn and it is There are liquid and granular fabric conditioning compositions and stain and/or odor removal compositions that are formulated to remain deposited during at least the initial period of wear or use. Typically, such compositions will contain from about 0.01% to about 20%, preferably from about 0.1% to about 10%, of some amine compounds of the invention.

D. Sanitary products and diapers Another aspect of the invention relates to a composition for suppressing non-microbial malodors in a sanitary product or diaper (including adult incontinence) product, comprising an adsorbent substrate carrier and a deodorizer of the invention. . As used herein, "adsorbent substrate carrier" refers to an adsorbent layer or core of material containing wood pulp fibers, cotton fibers, polyester fibers, or other liquid or solid adsorbent materials.

Deodorizing compositions containing the deodorizing agent of the present invention for use in controlling urine pace and menstrual fluid-based malodors include, but are not limited to, sanitary products such as sanitary napkins and panty liners, and diapers for infants and adults. . Another aspect of the present invention provides deodorizers and deodorizing/preservative compositions for use in toilet bowls, cosmetic utensils, sanitary products, and bedding, including the deodorants and fragrances or antibacterial agents of the present invention.

E. Methods The present invention involves the topical application of a safe and effective amount of one or more of the partial amine compositions of the present invention to the skin, i.e., the axillary and groin regions of the body, which are subject to both apocrine and eccrine secretions.
Also provided are methods for controlling or inhibiting malodor, preferably human sweat malodor.

Methods of using the compositions of the present invention to control non-microbial malodors include topical application of the compositions of the present invention, wherein the compositions have a concentration of from about 0.002 to about 4.0, preferably from about 0.01 to Approximately 1. , Omg of deodorant is preferably applied per 1 C of skin.

Additionally, the present invention provides a method for controlling non-microbial malodors in clothing and fabrics by depositing a safe and effective amount of some of the amine agents of the present invention into the clothing or fabrics. Preferably, the deodorizing composition is applied to the garment in areas that, when worn, typically come into contact with both the ephrine and apocrine glands, particularly the axillary and crotch areas. Preferably about 0
．． 0.002 to about 4.0 mg, preferably about 0.01 to about 1
．． 0g of rice amine deodorizer can be used on clothing or fabrics
It is deposited on the spot.

The invention also provides a method of contacting an article of clothing or fabric with an aqueous detergent solution containing from 0.1 to about 2% by weight of the detergent composition of the invention. Fabrics to be laundered are agitated in these solutions, preferably in automatic washing machines, to provide cleaning, soil removal, fabric care benefits, and odor control.

The composition can also be applied to the article by tamping the garment or fabric with the composition in an automatic washer/dryer.

The present invention also provides a method for suppressing malodor, which involves contacting or depositing the rice amine deodorizer of the present invention on sanitary products that come into contact with urine, feces, and/or menstrual fluid. A preferred method further involves contacting or depositing a deodorant onto the sanitary product containing the adsorbent substrate carrier.

The following non-limiting examples describe compositions of the present invention.

Compositions of the invention for topical administration are prepared as follows: Example 1 Ingredients
quantity dipropylene glycol
28% Sodium Stearate
6% propylene glycol (3) myristyl ester 2196 cyclodecamethylbentasiloxane 19% ethanol
24.7905-Chloro-2-(2,4-dichlorophenoxy)phenol
0.3% p-methylaniline
1.0% 100.0% p-Methylaniline is mixed with the other above ingredients for use as a deodorizer using methods known in the art. p-methoxy, niline, or other rice amine compounds useful in the compositions of this invention may replace the primary amines described above in the present compositions.

Example 2 Ingredients
QuantityCyclodecamethylpentasiloxane
39% dipropylene glycol
25% propylene glycol (3) myristyl ester 20% aromatic delta
1.49゜ethanol
13.6% p-methylaniline 1.09
0100.0% p-Methylaniline is mixed with the other above ingredients for use as a deodorizer using methods known in the art. p-methoxyaniline or other rice amine compounds useful in the compositions of the invention may replace the primary amines in the compositions.

Example 3 Ingredients
quantity propylene carbonate
8.7% propylene glycol
4.3% dipropylene glycol
3696 polyethylene glycol (n-6) io% propylene glycol (3) myristyl ester 10% myritix 925 bottles
4.9% ethanol
24,8%5-chloro-2-(2,4-dichlorophenoxy)phenol 0.3%p-methylaniline 1.0%i
oo, o% Mfllican Chemicals
icals) [Inman, South Carolina] The supplied p-methylaniline is mixed with the other above-described ingredients for use as a deodorizer using methods well known in the art. p-methoxyaniline or other rice amine compounds useful in the compositions of the invention may replace the primary amines in the compositions.

Example 4 Ingredients
amount ethyl acetate
30.7% cyclodecamethylpentasiloxane
68% 5-chloro-2-(2,4-dichlorophenoxy)phenol 0.3% p-methylaniline 1.0%100
．． The 0% p-methylaniline is mixed with the other above ingredients for use as a deodorizer using methods known in the art. p-methoxyaniline or other rice amine compounds useful in the compositions of the invention may replace the primary amines in the compositions.

Example 5 Ingredients
amount ethyl acetate
30.790 Cyclodecamethylpentasiloxane
68905-Chloro-2-(2,4-dichlorophenoxy)phenol 0.3% p-methylaniline! ,090
The 100.09° p-methylaniline is mixed with the other above-described ingredients for use as a deodorizer using methods well known in the art. p-methoxyaniline or other rice amine compounds useful in the compositions of the invention may replace the primary amines in the compositions.

Example 6 Ingredients
quantity diethyl ether
30.796 Cyclodecamethylbentasiloxane
689゜5-chloro-2-(2,4-dichlorophenoxy)phenol 0J96p-methylaniline 1.0%1
00.0% p-methylaniline is mixed with the other above ingredients for use as a deodorizer using methods known in the art. p-methoxyaniline or other rice amine compounds useful in the compositions of the invention may replace the primary amines in the compositions.

Example 7 A granular detergent composition for household laundry is as follows: Ingredients
Amount (0,1) C14-015 sodium alkyl sulfate 13.3 C13 linear alkyl sodium sulfonate 5.7
C12-C13 alkyl polyethquinate sodium toluene sulfonate 1
．． 0*T14S/TL)S sodium salt, T)ts:
TDS weight ratio 8B/14 25. ON-
Hydroxyethylethylenediaminetriacetate sodium
2.0 Sodium Polyacrylate (Average M 500
0) 2.0 Sodium Carbonate
20.3 Sodium silicate
5.8 polyethylene IJ coal (average M.W. approx. 8
000) 1. Op-methylaniline 1.0 sodium sulfate, water and other #
1100,0 Zero TMS/TDS- TMS to TDS weight ratio 85/1
A mixture of tartrate monosuccinate and tartrate disuccinate in the pentasodium salt form.Loga ingredients including flavoring agents, buffering agents, colorants, opacifiers, etc. are added together with a sufficient excess of water (40% total) with continuous mixing. to form an aqueous slurry and then spray dry to form the composition. p-methoxyaniline or other rice amine compounds useful in the compositions of the invention may replace the primary amines in the compositions.

Example 8 A liquid detergent composition for household laundry is as follows: Ingredients
Amount (%) C14-C15 alkyl polyethoxy (2
．． 5) Potassium sulfate 8.3C12-014 alkyldimethylamine oxide 3.3 Potassium toluenesulfonate
5,0 monoethanolamine
2.3TMS/T moxibustion triethanolamine salt, 85/15 T? companion/■β
15.01, 2-dihydroxy-3,5-disulfobenzene potassium salt 1.5 Potassium polyacrylate (average M.W. approximately 9000) 1.5p
-Methylaniline
1.0 Water and Others *621 1 Ingredients including fragrances, buffers, colorants, opacifying agents, etc. are added together with continuous mixing to form a composition. p-methoxyaniline or other rice amine compounds useful in the compositions of the invention may replace the primary amines in the compositions.

Example 9 Other granular detergent compositions of the present invention include the following ingredients.

Ingredients
9o (police t) 12,3 linear alkylbenzene sulfonate sodium] 5.8C14-C
15-alkyl sodium sulfate
6.8C12-C13 alcohol ethoxylate (
EO 6) 0.5 sodium tripolyphosphate
6.8 Sodium birophosphate
13.1 Sodium birophosphate acid
12.4 Sodium silicate (Nap/5i02 ratio 1..6)
7.6 Polyethylene glycol 11
1000 0.6
Sodium polyacrylate (M, W, 4500)
3.4 Protease enzyme *1,
8 Sodium perborate tetrahydrate
Sodium 1,9 sulfate
14.4 kanarin
0.
05 remainder (contains water, brightener, fragrance, foam suppressant)
14.85 ioo.

Prepare and spray dry an aqueous clarification mix of the reported detergent composition at pH 9.2 Anson units/g of a 1% aqueous solution at 20°C, with the exception of sodium pyrophosphate acid, enzymes and fragrances. Mix them to contain the above ingredients at the indicated levels.

Example 10 Another granular detergent composition for household laundry is as follows: Ingredients
5 and 13.3 C1,4-015 Sodium alkyl sulfate 013 Sodium straight chain alkylbenzenesulfonate 5
．． 71.0 C12-013 alkyl polyethoxylate (6,5)
Sodium toluene sulfonate
1,0 bottles TMS/T sodium salt, TMS
:TDS weight ratio 8B/14 25. ON-Hydroxyethylethylenediaminetriacetate sodium
2.0 Sodium polyacrylate (average M1 approximately 500
0) 2.0 Sodium Carbonate
20.3 Sodium silicate
5,8 polyethylene glycol (average H value approx. 8000
) 1.0 kanarin
, 05 Sodium Sulfate, Water and Others
Mixture of tartaric acid monosuccinate and tartaric acid disuccinate in the form of sodium salt *1 Various ingredients including fragrance, buffering agent, coloring agent, opaque MJ, etc. are combined with a sufficient excess of water (40% in total) under continuous mixing. The composition is formed by adding an aqueous ester and then spray drying.

Example 11 Another liquid detergent composition for household laundry is as follows: Ingredients
ll(OO)CI4-CI5alkylpolyethoxy(2,5) sulfuric acid 1 unit 8.3CI2"CI
4-alkyldimethylamine oxide
3.3 Potassium toluenesulfonate
5.0 monoethanolamine
2.3TMS/TD
S l-liethanolamine salt, 85/157MS/
71) S 15.01.2-dihydroxy-3,5-disulfobenzene potassium salt 15 potassium polyacrylate (average q, v, about 9000)
1.5 kanarin
0.01 Water and others *63.
09 1Q0.0 1 Ingredients including aromatic agents, buffering agents, colorants, opacifying agents, etc. are added together with continuous mixing to form a composition.

Example 12 Fabric conditioning agent ingredients
Amount (%) Ditallow dimethylammonium chloride (DT
DMAC) 3,7methyl-1-
Tallow amidoethyl 2-tallow imita'zoline 3.
7 kanarin
0,1 water and others
92.5100.0 The disclosed rice amine compounds suppress human sweat as well as various other malodors. Such other malodors include, but are not limited to, environmental odors and chemical odors. In addition, the disclosed rice amine compounds can be used from a variety of porous and non-porous surfaces including, but not limited to, plastics, wood, hair, glass, porcelain, fabrics, fibers of various compositions, foods and beverages. Suppresses negative odors generated or deposited on it. Such negative odors may be suppressed by applying a rice amine compound to the surfaces before, during or after the odor is generated, or by applying a rice amine compound to these surfaces during manufacture. As used herein, "controlling odors, malodors, or negative odors" means to prevent, inhibit, or convert the formation of such odors. As used herein, "negative odors or malodors" means: Refers to an undesirable odor emanating from a specific surface or product.

The inventors have further determined that the disclosed rice amine compounds, preferably canalin, are highly effective in controlling malodors associated with laundry cleaning products. Although the mechanism involved in this deodorization is unknown, it is thought to be something other than interaction with the vitamin B6 reaction. Although such surprising applications are extremely useful in fragrance-free laundry product compositions, it is important to note that these compositions do not contain any substitutes thereof, including but not limited to solvents, enzymes, surfactants, or contaminants. This is because they often have a negative odor emanating from them. In addition to deodorizing these negative odors, primary amine deodorizers enhance positive odors in laundry products such as air fresheners.

The present invention further relates to compositions useful in controlling malodors associated with chemical formulations of laundry cleaning products. A laundry product composition with a low negative laundry product odor is about 0.00
Contains 1 to about 20% rice amine compounds.

The invention further relates to methods effective in controlling malodors associated with chemical formulations of laundry cleaning products. A method for controlling negative laundry product odors includes from about 0.001 to about 2096 rice amine compounds in the laundry product composition.

Applicant's representative: Mr. Sato

Claims (1)

[Claims] 1. A deodorizing composition for suppressing bad odor caused by perspiration, which includes a) R-NH_2, ▲numerical formula, chemical formula, table, etc.▼
, R-NHNH_2, R-O-NH_2 and RC(O)
R^3NNH_2 [In the above formula, R is ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ (R^1 is hydrogen, hydroxy, C_1-C
_2_0 straight chain or branched alkyl and hydroxy C_
1-C_2_0 linear or branched alkyl ether), -CHR^2CO_2H(R^
2 is selected from the group consisting of hydrogen, aryl and C_1-C_2_0 straight or branched chain alkyl) and C_1-
a safe and effective amount of a primary amine compound having the general formula selected from the group consisting of C_2_0 straight or branched chain alkyl; A composition comprising: a carrier; and is suitable for application to clothing worn on or near the skin. 2.R is ▲There are mathematical formulas, chemical formulas, tables, etc.▼, C_1-
The deodorizing composition for suppressing sweating malodor according to claim 1, which is C_6 straight chain or branched alkenyl or alkanyl or C_1-C_2_0 straight chain alkenyl or alkanyl. 3. The deodorizing composition for suppressing bad odor caused by perspiration according to claim 2, wherein R is C_1-C_6 linear alkanyl. 4. The primary amine compound has the general formula R-NH_2 or R-N
HNH_2, R is -CHR^2CO_2H, and R^2 is selected from the group consisting of hydrogen, aryl, C_1-C_1_0 straight-chain or branched alkenyl and C_1-C_2_0 straight-chain or branched alkanyl. Item 1. The deodorizing composition for suppressing bad odor caused by perspiration according to Item 1. 5. The deodorizing composition for suppressing bad odor from perspiration according to claim 4, wherein R^2 is C_1-C_6 straight chain or branched chain alkanyl. 6. The deodorizing composition for suppressing bad odor from perspiration according to claim 4, wherein the primary amine compound is selected from the group consisting of phenylhydrazine, canalin, and aminoacetic acid. 7. The primary amine compound has the general formula R-NH_2, and R
is ▲There are mathematical formulas, chemical formulas, tables, etc.▼, and −R_1
The deodorizing composition for suppressing bad odor from perspiration according to claim 1, wherein is selected from the group consisting of hydroxy, short chain alkyl, and short chain alkyl ether of hydroxy. 8. The primary amine compound is p-methoxyaniline and p-
The deodorizing composition for suppressing bad odor caused by perspiration according to claim 7, which is selected from the group consisting of methylaniline. 9. The deodorizing composition for suppressing sweating malodor according to claim 1, 3, 6, 7 or 8, further comprising an antibacterial deodorizing agent. 10, a) R-NH_2, ▲There are mathematical formulas, chemical formulas, tables, etc.▼, R-NHNH_2, R-O-NH_2 and RC
(O) R^3NNH_2 [In the above formula, R is ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ (R^1 is hydrogen, hydroxy, C_1-C_2_0 straight chain or branched chain alkyl and hydroxy C_1-C_2_0 straight chain or branched -CHR^2CO_2H (R^2 is selected from the group consisting of hydrogen, aryl, and C_1-C_2_0 straight-chain or branched alkyl); and C_1-C_2_0 straight-chain or branched alkyl ethers); selected from the group consisting of chain alkyl; R^3 is C_1
a safe and effective amount of a primary amine compound having the general formula selected from the group consisting of -C_6 alkyl; and b)
A deodorizing composition comprising: a carrier for laundry products. 11.R is ▲There are mathematical formulas, chemical formulas, tables, etc.▼,
11. The deodorizing composition of claim 10, wherein -R_1 is selected from the group consisting of hydroxy, short chain alkyl, and short chain alkyl ether of hydroxy. 12, a) R-NH_2, ▲There are mathematical formulas, chemical formulas, tables, etc.▼, R-NHNH_2, R-O-NH_2 and RC
(O)R^3NNH_2 [In the above formula, R is ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ is hydrogen, hydroxy, C_1-C_
2_0 Straight or branched alkyl and hydroxy C_1
-C_2_0 straight or branched chain alkyl ether), -CHR^2COH (R^2 is selected from the group consisting of hydrogen, aryl and C_1-C_2_0 straight or branched alkyl) and C_1 -C_2
a safe and effective amount of a primary amine compound having the general formula selected from the group consisting of __0 straight or branched chain alkyl; R^3 is C_1-C_6 alkyl; and b) fabric treatment. A deodorizing composition comprising: a carrier for; 13. A method for suppressing malodor from clothing, comprising depositing a safe and effective amount of the composition according to claim 10, 11 or 12 on the clothing.