JPH04187623A - Hair cosmetics - Google Patents

Abstract

PURPOSE:To provide a hair cosmetic containing an extract of Eucommia ulmoides Oliver as an ingredient and exhibiting excellent canities-preventing and improving activity when externally applied to scalp and having high safety. CONSTITUTION:A hair cosmetic contains an extract as an ingredient usually in an amount of 0.05-20.0wt.% based on all weight of the hair cosmetic, the hair cosmetic exhibiting excellent canities-preventing and improving activity but not exhibiting any skin irritation and allergic property, and the extract being obtained by extracting Eucommia ulmoides Oliver having been used as a Chinese medicine such as an antasthenic or an analgesic for lumbago, arthritis or rheumatism e.g. with water or a lower alcohol such as methanol, ethanol or butanol, preferably ethanol.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a hair cosmetic, and more particularly to a hair cosmetic containing an extract of Mori zhong as a compounding ingredient. It is.

[Background Art] Hair dyes based on physicochemical dyeing have conventionally been used as one of the means for improving gray hair.

However, hair dyes have been problematic in terms of safety, such as their cumbersome operation, irritation to the scalp, and sensitization.
Japanese sushi is also not a means to satisfy the needs of users. In addition, there have been proposals regarding methods for preventing or improving the occurrence of gray hair itself using drugs (for example, JP-A-58-99417, JP-A-62-6350).
No. 9, Japanese Patent Publication No. Sho f32'-63510, Japanese Patent Publication No. Sho 62-4
No. 55275, JP-A-63-183518, JP-A-6
4-25712, JP-A-1-207225, etc.). However, these methods also prevent gray hair,
It has no practical effect on the purpose of improvement, and
In terms of safety, satisfactory effects have not necessarily been obtained.

[Object of the invention] The purpose of the present invention is to provide a hair cosmetic that exhibits excellent gray hair prevention and improvement effects when applied externally to the scalp, and is highly safe for the skin. It is.

[Disclosure of the Invention] As a result of many years of research in order to develop an agent for preventing and improving gray hair that has practical effects, the present inventors have developed an extract of Du Zhong, which is known as a Chinese herbal medicine, for external use. It has been found that this results in the prevention and improvement of gray hair. The present invention has been made based on this knowledge.

Eucommia is the dried trunk bark of Eucommia, a species of Eucommia that is distributed in central China. Konomo9 has traditionally been used as a tonic and analgesic for lower back pain, arthritis, and rheumatism as a Chinese herbal medicine. Furthermore, in recent years, development as a drug for hypertension has progressed, but it has not been used at all in the field of cosmetics.

The present inventors focused on the strength of the physiological activity of this mori, and found that it is the best acid for preventing gray hair! Various studies were conducted regarding its potential as an F agent. In other words, we conducted extensive research on the extract obtained by extracting Mori Zhong with water or lower alcohols, and found that the extract activates melanocytes in animal hair and darkens gray hair that occurs due to aging in mice. Moreover, it has been found to be effective in preventing and improving gray hair in humans. The present invention was made based on this knowledge.

The present invention is directed to providing a hair cosmetic that is characterized by containing as a compounding ingredient an extract obtained by extracting Mori annua with an extraction solvent.The present invention will be described in detail below.

The mori applied to the hair cosmetic according to the present invention is Eucomia ulrmoides EucoIlnia ulrQoid.
s.

Dried stem bark of a plant belonging to the genus Eucommia0
The benzonia used in the hair cosmetics according to the present invention can be obtained by cold-extracting or hot-extracting the benzonia with a suitable extraction solvent, such as water or a lower alcohol such as methanol, ethanol, and butanol, preferably ethanol. The resulting extract is used.

An example of manufacturing the Mori extract used in the hair cosmetic of the present invention is shown below.

Production Example 1〉 Mori 2 k+r was mixed with 20j of ethanol for 3 days each.
Cold immersion extraction is carried out several times. The obtained extracts were combined and ethanol was distilled off using an evaporator to obtain approximately 0.3b
Obtain the extract of z.

<Manufacturing Example 2> 2 kg of Mori Zhong, 20. Digestion extraction is carried out three times for three days each with fl water. The obtained extracts are combined and water is distilled off using an evaporator to obtain an extract of about 0.1 bz.

Extraction obtained in these two production examples! P! l! The lth color is
Both have a brownish color, but the ethanol extract is darker than the water extract. 40 each for both
The product was left for about 1 month at C and examined for changes in properties, but it was found to be stable with no change in color tone or odor. In the hair cosmetic according to the present invention, the amount of the extract of Mori Zhong used is usually 0.05-20.0% by weight based on the total weight of the hair cosmetic. When applied externally, it exhibits excellent gray hair prevention and improvement effects, and is highly safe for the skin.The dosage form of the hair cosmetic according to the present invention includes various agents that are not intended for application to hair. A wide variety of externally applicable dosage forms can be taken, for example, hair tonics, hair creams, hair lotions, milky lotions, ointments, hair treatments, hair conditioners, and the like.

Ingredients used in the hair cosmetic according to the present invention include various materials usually used in this type of external preparation, for example,
The base ingredients include water, ethanol, various hydrocarbons, higher alcohols, esters, higher fatty acids, various surfactants, etc., and the additive ingredients include fragrances, pigments, preservatives, and antioxidants. and various medicinal ingredients.

In the hair cosmetic according to the present invention, other substances known as substances for preventing and improving gray hair may be included in combination.

The present invention will be described below with reference to Examples and Comparative Examples. In addition, the blending amounts in the examples are shown in parts by weight.

Examples, Comparative Examples Hair Tonic (Formulation) Table 1 Ethanol 79.89 79.89 8
0.89 Polyoxyethylene hardened mustard oil f40E, o,) 0.5 0.5
0.5 Mori Zhong - Ethanol Extract (Production Example 1) 1.0 0゜00.0 Mori Zhong -
Water extract (Production example 2> 0.0 1.0 0.0
Purified water 18.5 18.5 18.
5 Fragrance 0.1 0.1 0.1 Production method> For each side, ethanol, Morizhong extract (not used in the comparative example), polyoxyethylene hardened mustard oil (40%
E, O9), fragrance and coloring matter are added, stirred and dissolved, then purified water is added and stirred to prepare a lotion.

Next, a description will be given of gray hair prevention/improvement tests in animals, safety tests, and gray hair prevention/improvement tests in humans conducted on hair cosmetics different from the present invention.

<Grey hair prevention/improvement experiment using animals> By applying each of the hair tonics of the above examples and the hair tonic of the comparative example as an experimental control directly to the hair caused by aging of animals, it was possible to reduce gray hair. Progress prevention and improvement were observed.

Each of the hair tonics of Examples 1 and 2 and the hair tonic of Comparative Example 1 showed that the hair tonic of Example 1 and Comparative Example 1 had white hair due to aging in the black hair of C57BL/6J mice at 1.5 years of age. A mixed set of mice was used. A total of 3 groups were established for each sample, with 10 C57BL mice per group.

0.05 tpe/■2 of Honjima was sufficiently rubbed twice a day on the skin at the root of the hair on the scalp of the animal, and the application was continued for 3 months.

From the observation progress during the application period, it was observed that the white hairs were not completely replaced by black hairs during the application period, and although the tips of the hairs were white, it was observed that the hairs turned black from the roots to the middle of the hairs. Therefore,
As an evaluation method, white hairs from the tips of the mice's heads are randomly pulled out, and the number of hairs that are pulled out and the number of hairs that are even slightly black from the roots are counted, and the value is calculated by dividing the latter by the former. was taken as the frequency of occurrence of black hair.

The results were subjected to a t-test (comparison between groups) to evaluate the significance of the graying effect of the samples.

As is clear from Table 2, each of the hair toning treatments of Examples 1 and 2 caused white hair masculinization compared to the hair toning treatment of Comparative Example 1, demonstrating its effectiveness. In addition, Example 1 containing ethanol extract and Example 2 containing water extract
The results showed that the ethanol extract was more effective than the water extract.

In addition, tissue from mice was collected and stained with DOPA to examine the activation of hair follicle melanocytes. In the products of Examples 1 and 2, compared to the product of Comparative Example 1, the hair roots where melanocytes are present were clearly more strongly stained by DOPA, and it was observed that the melanocytes in the hair roots were activated. It was done.

Therefore, it is thought that this changes white hair into black hair by activating melanocytes in the hair root.

Safety Test> Before evaluating the effects on humans, a human patch test was conducted as follows in order to examine the irritation of the hair cosmetic according to the present invention to the skin.

Each hair tonic of Example 1 and Example 2 was used as a sample.

The test subjects were 45 adult females per group, and a human forearm closed patch test was conducted for 24 hours.

Judgment criteria were based on the following criteria.

Strong erythema ++ Erythema Slight erythema Negative - Table 3 Human batch test results As is clear from Table 3, all of the hair cosmetics according to the present invention were found to be irritating. In addition, a skin secondary irritation test and an allergy test using animals were conducted as safety tests, and no skin irritation or allergy was observed, indicating that the product was extremely safe for the skin.

Human Gray Hair Prevention/Improvement Test> Based on the above results, the following test was conducted in order to apply the hair cosmetic according to the present invention to human gray hair and examine its effect on gray hair prevention and improvement.

Pierre Blue 1 Each hair tonic of Example 1 and Example 2, hair tonic of Comparative Example 1 40 to 6 with gray hair for each sample as a test subject
Thirty men and women aged 0 years were divided into 3 groups, and 1 rsll of each sample was rubbed onto the scalp twice a day for 5 months of continuous use.

L-Kitate-Nira The condition of the rubbed area was photographed and compared before and after using the sample, and the effect of preventing and improving gray hair was evaluated. In addition, the evaluation criteria were as follows in each case.

Significant effect 10% effect 10% moderately effective ± no effect ~ Table 4 Human effect test As is clear from Table 4, both the hair tonic of Example 1 and the hair tonic of Example 2 have no effect on gray hair. It was confirmed that the hair growth rate did not increase and showed excellent effects on preventing and improving gray hair. On the other hand, in Comparative Example 1, little effect was observed.

Example 3 Hair cream formulation〉 Production method〉 Prescription raw materials A and B are respectively heated and dissolved and kept at 80''C. Place A in a container of a homomixer equipped with a temperature controller,
Add B and mix and emulsify. The mixture was cooled to room temperature while stirring to obtain a cream type agent for preventing and improving gray hair.

Effects of the Invention J As described above, the hair cosmetic according to the present invention has an excellent effect of preventing and improving gray hair, and has no skin irritation or allergy.

Claims (1)

[Scope of Claims] 1) A hair cosmetic comprising, as a compounding ingredient, an extract obtained by extracting Mori annua with an extraction solvent. 2) The hair cosmetic according to claim 1, wherein the extraction solvent is selected from water and lower alcohols.