JPH04187235A - Gelatinous composition - Google Patents

Abstract

PURPOSE:To enable gelatinization without using a high molecular compd., a surfactant, oil, etc., by adding a silk fibroin deriv. to alcohols and water. CONSTITUTION:A gelatinous compsn. is composed of 1-30wt.% silk fibroin deriv., 5-70wt.% alcohols and 20-90wt.% water. Since the silk fibroin deriv. as the principal ingredient has high safety and useful action as cosmetics, the gelatinous compsn. can be prepd. as gelatinous cosmetics.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The present invention relates to a gel composition. More specifically, it relates to a gel composition that can be used, for example, as cosmetics, pharmaceuticals, foods, fragrances, and the like.

[Prior Art] Protein (protein) hydrolysates and their derivatives are manufactured and adjusted to be water-soluble in -G, and unlike the starting material protein, they generally do not gel by themselves.

For example, when an organic solvent is added to such an aqueous solution, the protein hydrolyzate or its derivative becomes insolubilized and does not gel, although it depends on the amount.

Therefore, when blending protein hydrolysates and their derivatives into cosmetics, pharmaceuticals, foods, fragrances, etc. and making them into gels, polyacrylic acid, polyacrylates, hydroxyethylcellulose, water-soluble chitosan,
Gelation has been carried out by adding a polymer compound such as a carboxyvinyl polymer, or by adding a surfactant and an oil agent.

[Problem to be solved by the invention]

However, in some cosmetics, pharmaceuticals, foods, fragrances, etc., polymer compounds added as gelling agents, surfactants, oils, etc. may have an adverse effect on quality, performance, and safety.

Therefore, the present invention provides protein hydrolysates and their derivatives with polymeric compounds as gelling agents, surfactants,
The purpose of the present invention is to provide a gel composition that can be gelled without using oil or the like and used as cosmetics, medicines, foods, fragrances, etc.

[Means to solve the problem]

The present inventors have conducted extensive research into gelling various protein hydrolysates and their derivatives without using polymer compounds, surfactants, oils, etc. as gelling agents, and found that string fibroin The inventors discovered that derivatives, that is, silk fibroin-derived peptides obtained by hydrolyzing silk protein and derivatives thereof, can be gelled with alcohols and water, leading to the completion of the present invention.

That is, the present invention provides the following (a) to (c) components (a)
The present invention provides a gel composition characterized by containing a silk fibroin derivative, (b) alcohol, and (c) water.

In the present invention, the silk fibroin derivative used as component (a) is derived from silkworms (silkworms), as will be explained in detail later.
It is derived from silk proteins such as cocoons, silk threads, and silk cloth, and is highly safe. It is also highly safe and has a strong effect on hair due to the effects of the amino groups and carboxyl groups derived from silk proteins, as well as the side chains of various amino acids. It has the effect of preventing hair damage by adsorbing it to hair and restoring damaged hair.

It also has the effect of imparting shine and moisture to the hair, improving the texture of the hair, and smoothing the hair to improve combability.

Furthermore, silk fibroin derivatives have good affinity for the skin, and have the effect of imparting luster and moisture to the skin, and smoothing the skin.

Therefore, when cosmetics are prepared using the above-mentioned components (a) to (c) as essential ingredients, gel-like cosmetics are obtained. In addition, focusing on the characteristics of component (a) being highly safe and having good digestibility, it is possible to prepare pharmaceuticals, foods, etc. using components (a) to (c) as essential components, and gel-like pharmaceuticals,
You can get food etc. Furthermore, the above-mentioned (a) component has a fragrance-preserving effect and suppresses the volatilization of volatile components such as fragrances, so if a fragrance is prepared with components (a) to (c) as essential components, a gel-like fragrance is obtained.

As a result, it has become possible to obtain gel-like cosmetics, pharmaceuticals, foods, fragrances, etc. that could not be obtained by using protein hydrolysates or their derivatives, and the advantages of silk fibroin derivatives derived from natural products. Its properties can also be utilized in gel-like cosmetics, pharmaceuticals, foods, fragrances, etc.

In the gel composition of the present invention, the preferred blending ratio of the components (a) to (c) is 1 to 30% by weight, particularly 3 to 25% by weight of the silk fibroin derivative as the component (a), and (b)
The alcohol component is 5 to 70% by weight, especially 10 to 55% by weight.
% by weight, component (c) water is 20 to 90% by weight, especially 40% by weight.
~80% by weight.

In other words, if the blending ratio of component (a) is less than 1% by weight, the effect based on the silk fibroin derivative will not be fully exhibited; When the amount exceeds 30% by weight, it becomes difficult to obtain a gel-like state. If the blending ratio of the alcohol component (b) is less than 5% by weight, the silk fibroin derivative will dissolve in water and will not form a gel.
If the amount exceeds % by weight, the silk fibroin derivative becomes insolubilized and a gel-like composition cannot be obtained. If the blending ratio of component (c) water is less than 20% by weight, the silk fibroin derivative becomes insolubilized and a gel-like composition cannot be obtained;
If the blending ratio of component (c), water, exceeds 90% by weight, the silk fibroin derivative will dissolve in water, making it impossible to obtain a gel-like composition.

The gel composition of the present invention only needs to contain the above components (a) to (c) as essential components;
In addition to component c), other components may also be blended, but the above (a)
Even when other components are blended, the blending ratios of components (a) to (c) may be maintained at the above ratios among components (a) to (c).

Next, the silk fibroin derivative of component (a) will be described in detail.

Examples of silk fibroin derivatives include those consisting of the following (1) to (2).

■ General formula (I): H-4N H-CH-, C, O OH (in the formula, R1 is a side chain of various amino acids constituting the silk fibroin-derived peptide, and n is 3 to 100) Silk fibroin-inducing peptide represented by the general formula (■
): OR+ 1R2-C→NH-GH-Co AyuOOMΦ (in the formula, R2
and n are the same as in the above general formula (1), and R2 is an alkyl group having 1 to 21 carbon atoms, an alkenyl group having 1 to 21 carbon atoms, or a side chain of a resin acid. M is H, Na, K or NH4, monoethanolamine, jetanolamine, triethanolamine, 2-amino-2-methyl-
1-propanol, 2-amino-2-methyl-1,3-
onium of organic alkanolamines such as propanediol).

Acylated product of silk fibroin-derived peptide or its salt represented by ■ General formula (■) = R, R.

R, -N
3, R,, R, is an alkyl group having 1 to 22 carbon atoms or an alkenyl group having 2 to 22 carbon atoms, or one or two of R3-R1 is an alkyl group having 1 to 22 carbon atoms or an alkenyl group having 2 to 22 carbon atoms. ~22 alkenyl groups, the rest having 1 carbon number
~3 alkyl group, a hydroxyalkyl group having 1 to 3 carbon atoms, or a benzyl group. A is an alkylene having 2 to 3 carbon atoms or a hydroxyalkylene having 2 to 3 carbon atoms) Quaternary ammonium derivative of silk fibroin-derived peptide General formula (■): H) NH-CH-Co ○R6 (In the formula, R5 and n are the same as in the above general formula (1), and R6 is a linear alkyl group having 1 to 18 carbon atoms, a branched alkyl group having 1 to 18 carbon atoms, and a carbon number Ester of a silk fibroin-derived peptide represented by a linear hydroxyalkyl group having 1 to 18 carbon atoms or a branched hydroxyalkyl group having 1 to 18 carbon atoms Silk fibroin derivative represented by the general formula (1) of (1) above Silk proteins that are raw materials for obtaining peptides include silkworm cocoon (silkworm), 11, silk cloth, and the like. In particular, silkworm cocoons are cotton-like before spinning.
It is economically advantageous to use a coarse filament. For hydrolysis, silk protein may be cut or crushed into appropriate sizes, or may be washed or subjected to high-temperature pressure treatment, if necessary. In addition, silk protein can be dissolved in a highly concentrated aqueous solution of 40% by weight or more of an alkali metal halide salt such as lithium bromide or an alkaline earth metal halide such as calcium chloride, so silk protein can be dissolved once in such a solution. It may be dissolved in an aqueous solution and the solution may be hydrolyzed.

The silk fibroin-derived peptide represented by the general formula (1) can be obtained from the silk protein by hydrolyzing the silk protein using an acid, an alkali, a protease, or the like.

During hydrolysis, by appropriately selecting the amount of added acid, alkali, or enzyme, reaction temperature, and reaction time, the value of n of the obtained silk fibroin-derived peptide can be adjusted to 3.
~100, i.e. about 200 to about 85,000 in molecular weight
(When the value of n is small, amino acids with small molecular weights happen to be lined up, and when n = 3, the molecular weight may be about 200, but when the value of n is large, It is unlikely that only amino acids with small molecular weights are lined up, but amino acids with large molecular weights are also included, so when n = 100, the molecular weight may be about 85,000).

For acid hydrolysis of silk protein, inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, nitric acid, and hydrobromic acid, acetic acid, formic acid, etc.
Organic acids such as formic acid are used.

In addition, for alkaline hydrolysis of silk protein, for example, sodium hydroxide, potassium hydroxide, lithium hydroxide, barium hydroxide, sodium carbonate, potassium carbonate,
An inorganic alkali such as lithium carbonate is used.

For enzymatic hydrolysis of silk proteins, acidic proteolytic enzymes such as pepsin, protase A and protase B, and neutral to alkaline proteolytic enzymes such as papain, bromelain, thermolysin, trypsin, pronase, and chymotrypsin are used. Furthermore, fungi-produced neutral or alkaline proteolytic enzymes such as subtilisin and staphylococcal protease can also be used.

In the obtained silk fibroin-derived peptide represented by the general formula (1), the amino acids whose side chains are represented by R1 include alanine, glycine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, serine, Torenin, methionine, arginine,
histidine, lysine, aspartic acid, asparagine,
Examples include glutamic acid, glutamine, and tryptophan. Table 1 shows an analysis example of the composition ratio of these amino acids. Note that asparagine and glutamine are hydrolyzed during the analysis process to become aspartic acid and glutamic acid, respectively, so they are included in aspartic acid and glutamic acid in Table 1.

Also, tryptophan is not shown in Table 1 because it is decomposed during the analysis process. .

Table 1 In addition, the acylated product of the silk fibroin-inducing peptide represented by the general formula (n) in above (■) or its salt is obtained by adding a silk fibroin-inducing peptide represented by the above general formula (I) to a fatty acid or a resin acid, etc. It is an acylated product, which improves the permeability into the hair and imparts an oily component based on fatty acids or resin acids to the hair. The effect of giving shine and moisture to the hair is further improved.

Specific examples of the acylated silk fibroin-derived peptide represented by the general formula (II) or its salt include, for example, potassium salt of myristic acid condensate of silk fibroin-derived peptide, triethanol of coconut oil fatty acid condensate. salt, ammonium salt of palmitic acid condensate, potassium salt of undecylenic acid condensate, 2-amino-2-methyl-1,3-propanediol salt of isostearic acid condensate, sodium salt of oleyl acid condensate, resin acid condensate Examples include potassium salts of coconut oil and coconut oil fatty acid condensates.

The quaternary ammonium derivative of the silk fibroin-inducing peptide represented by the general formula (I
) is obtained by quaternizing the terminal amino group of the silk fibroin-derived peptide of formula (1).
The effect of silk fibroin-inducing peptide expressed by -
N shows remarkable results.

Specific examples of the quaternary ammonium derivative of the silk fibroin-derived peptide represented by the general formula (1) include trimethylammonio-2-hydroxypropyl derivative of the silk fibroin-derived peptide, lauryldimethylammonio- 2-hydroxypropyl derivative, triethylammonio-2-hydroxypropyl derivative,
Examples include coconut oil alkyldimethylammonio-2-hydroxypropyl derivatives, stearyldimethylammonio-2-hydroxypropyl derivatives, and benzyldimethylammonio-2-hydroxypropyl derivatives.

The ester of the string fibroin-inducing peptide represented by the general formula (■) in the above (■) is obtained by esterifying the silk fibroin-inducing peptide represented by the general formula (I) with a fatty acid or a hydroxy fatty acid. Formula (1)
In addition to the characteristics of the silk fibroin-derived peptide represented by , the introduction of an alkyl group or hydroxyalkyl group through esterification improves the effect of imparting wettability, oiliness, shine, etc. to hair.

Specific examples of the ester of the silk fibroin-derived peptide represented by the general formula (IV) include ethyl ester, isopropyl ester, 2-ethylhexyl ester, 2-hexyldecyl ester, and ethylene ester of the silk fibroin-derived peptide. Examples include glycol ester, propylene glycol ester, butylene glycol ester, and glycerin ester.

These silk fibroin derivatives can be used alone or as a mixture of two or more.

(b) Component alcohols include, for example, methanol, ethanol, propatool, isopropatool, 1
-Butanol, 2-butanol, isobutanol, tertiary butanol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, triglycerin, sorbitol Examples include monohydric alcohols and polyhydric alcohols.

The alcohol of component (b) may contain an ether bond in the molecule, such as diethylene glycol.

The gel composition of the present invention has the above-mentioned component (a), a navy blue fibroin derivative, component (b), alcohol, and component (c), water, as essential components. Other components can be added within a range that does not impair the effects of the invention.

Such components include, for example, alkyl sulfates such as ammonium lauryl sulfate, ethanolamine lauryl sulfate, sodium lauryl sulfate, triethanolamine lauryl sulfate, polyoxyethylene (2EO) lauryl-triethanolamine sulfate (EO is In ethylene oxide, the number before EO indicates the number of moles of ethylene oxide added), polyoxyethylene (3EO
) Alkyl (any one having 11 to 15 carbon atoms or a mixture of two or more) polyoxyethylene alkyl ether sulfates such as sodium ether sulfate, alkylbenzenesulfonic acids such as sodium laurylbenzenesulfonate, and triethanolamine laurylbenzenesulfonate salts, polyoxyethylene alkyl ether acetates such as polyoxyethylene (3EO) l lysosyl ether sodium acetate, sodium coconut oil sarcosine, lauroyl sarcosine triethanolamine, sodium lauroyl methyl-β-alanine, sodium lauroyl glutamate , lauroyl-glutamic acid triethanolamine, coconut oil fatty acid-sodium L-glutamate, coconut oil fatty acid-L-glutamic acid triethanolamine, sodium coconut oil fatty acid methyltaurate,
N-acylamino acid salts such as sodium lauroyl methyl taurate, sodium ether sulfate alkanesulfonate, sodium hydrogenated coconut oil fatty acid glycerin sulfate, disodium randecylenoylamide ethyl sulfosuccinate, sodium octylphenoxyjethoxyethyl sulfonate, oleic acid Disodium amidosulfosuccinate, dioctyl sodium sulfosuccinate, uryl disodium sulfosuccinate, polyoxyethylene alkyl (12 to 15 carbon atoms) ether phosphoric acid (8 to 10 EO)
Anions such as sodium polyoxyethylene oleyl ether phosphate, sodium polyoxyethylene cetyl ether phosphate, disodium uryl polyoxyethylene sulfosuccinate, sodium polyoxyethylene lauryl ether phosphate, sodium lauryl sulfoacetate, sodium tetradecene sulfonate, etc. surfactant, distearyldimethylammonium chloride, dipolyoxyethyleneoleylmethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, tri(polyoxyethylene)stearylammonium chloride, polyoxypropylene chloride Cationic surfactants such as methyldiethylammonium, myristyldimethylbenzylammonium chloride, lauryltrimethylammonium chloride, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine,
Undecylhydroxyethylimidazolium betaine sodium, undecyl-N-hydroxyethyl-N-carboxymethylimidazolinium betaine, steflyldihydroxyethylbetaine, stearyldimethylaminoacetic acid betaine, coconut oil alkyl betaine, coconut oil fatty acid amidopropyl betaine, coconut Oil alkyl N-carboxyethyl-N-hydroxyethylimidazolinium betaine sodium, Coco alkyl N-carboxyethoxyethyl-N-carboxyethylimidazolinium disodium hydroxide, Coco alkyl N-carboxymethoxyethyl-N-carboxy Methyl imidazolinium disodium lauryl sulfate, amphoteric surfactants such as N-coco fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate, polyoxyethylene alkyl (carbon number 12-14) ether (7EO), polio Quiethylene octylphenyl ether, polyoxyethylene oleyl ether, polyoxyethylene glyceryl oleate, polyoxyethylene stearyl ether, polyoxyethylene cetyl ether, polyoxyethylene cetyl stearyl diether, polyoxyethylene sorbitol lanolin (40F, 0) , polyoxyethylene nonylphenyl ether, polyoxyethylene polyoxybrobylene cetyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxypropylene stearyl ether, etc. Surfactant, cationized cellulose, cationized hydroxyethylcellulose, poly(
cationic polymers such as diallyldimethylammonium chloride), polyvinylpyridine, and polyethyleneimine;
Synthetic polymers such as amphoteric polymers and anionic polymers, isostearic acid jetanolamide, undecylenic acid monoethanolamide, oleic acid jetanolamide, bovine fatty acid monoethanolamide, hydrogenated bovine fatty acid jetanolamide, stearic acid jetanolamide, stearin Acid diethylaminoethylamide, stearic acid monoethanolamide, myristic acid jetanolamide, coconut oil fatty acid ethanolamide, coconut oil fatty acid jetanolamide, lauric acid isopropanolamide,
Thickeners such as lauric acid ethanolamide, lauric acid jetanolamide, lanolin fatty acid jetanolamide, waxes, paraffins, fatty acid esters, glycerides, fats and oils such as animal and vegetable oils, animal and plant extracts, polysaccharides or their derivatives, chain or silicone oil such as cyclic methylpolysiloxane, methylphenylpolysiloxane, dimethylpolysiloxane polyethylene glycol copolymer, dimethylpolysiloxane polypropylene copolymer, amino-modified silicone oil, quaternary ammonium-modified silicone oil, L-aspartic acid, L-
Examples include amino acids such as sodium aspartate, DL-alanine, L-arginine, glycine, L-glutamic acid, cysteine, and L-threonine.

Even when the gel-like composition of the present invention is prepared using only the silk fibroin derivative as the component (a), the alcohol as the component (b), and the water as the component (c), it can prevent hair damage, restore damaged hair, etc. It can be used as a hair cosmetic for the purpose of hair conditioning, or as a skin cosmetic for the purpose of adding luster and moisture to the skin and making the skin smooth. Furthermore, the gel composition of the present invention includes:
In addition to the above-mentioned components (a) to (c), other components may be blended to prepare gel-like hair cosmetics or gel-like skin cosmetics.

That is, the silk fibroin derivative of component (a) above, (
Ingredient b) alcohols and component (c) water are essential ingredients, and by blending these with other ingredients used as main ingredients or auxiliary agents in each cosmetic product, gel-like hair cosmetics and gel-like hair cosmetics can be created. It can be prepared as a skin cosmetic product.

Such hair cosmetics include, for example, hair rinses, hair creams, hair conditioners, hair treatments, setting gels, aqueous pomades, hair dye treatment agents, hair styling products, hair packs, pre-treatment agents for permanent waves, and permanent waves. Various hair cosmetics can be mentioned, such as intermediate treatment IJ and post-treatment agents for permanent waving.

In addition, skin cosmetics include skin treatments, vanishing creams, hunt creams, facial cleansing creams, face packs, skin gels, aftershave gels, gels for the face, limbs, and whole body, preshave gels, heavy gels, and makeup products. , sun protection products, and various skin cosmetics.

In addition, in the gel composition of the present invention, the main component (a), a silk fibroin derivative, is highly safe, and (a)
Since the ingredient silk fibroin derivative has good digestibility and is useful as a food, by selecting ingredient (b), it can be prepared not only as cosmetics but also as gel-like medicines, gel-like foods, etc. be able to.

That is, a highly safe substance such as ethanol is selected as the component (b), and the silk fibroin derivative as the component (a), alcohol as the component (b), and water as the component (c) are essential components, and together with these, Gel-like medicines and gel-like foods can be prepared by blending ingredients that are used as main ingredients and adjuvants in medicines and foods.

Such gel-like medicines include, for example, gel-like external preparations for skin, gel-form external preparations for hair or scalp, and examples of gel-like foods include, for example, gel-like jelly. , sweets, cakes, desserts, health foods, etc.

Further, the gel composition of the present invention can also be prepared as a gel fragrance. 'In this case, there are fewer restrictions than in the case of pharmaceuticals and foods, and the essential components are silk fibroin derivatives (a), alcohols (b), and water (c); A gel-like fragrance can be obtained by blending ingredients used as main ingredients and auxiliary agents.

The gel composition of the present invention can be prepared by various methods. For example, it may be prepared by dissolving the silk fibroin derivative as the component (a) in the water as the component (c), and adding and mixing the alcohol as the component (b) to the solution while stirring. Alternatively, it can be prepared by first mixing the alcohol component (b) and the water component (c), and then adding and mixing the silk fibroin derivative component (a) into the mixture. You can also do it.

Furthermore, it can also be prepared by mixing the silk fibroin derivative as the component (a), the alcohol as the component (b), and the water as the component (c) all at once. And above (
When blending other ingredients in addition to ingredients a) to (c),
These components may be added and mixed at appropriate stages.

〔Effect of the invention〕

In the gel composition of the present invention, the main ingredient (a), a silk fibroin derivative, is highly safe and has a useful effect as a cosmetic. Alternatively, a gel-like cosmetic can be prepared by adding other ingredients to the above ingredients (a) to (c).

In addition, the gel composition of the present invention can be used as a gel composition in addition to cosmetics, as the silk fibroin derivative of the component (a) is highly safe, has good digestibility, and has a fragrance-preserving effect. It can be prepared as food, fragrance, etc.

Furthermore, since the gel-like composition of the present invention is gel-like and has limited fluidity, it does not spill or flow out, so it can be packaged in light packaging such as tubes, and when used, it can be used in only the required amount. It can be taken out and used only on the necessary areas. Furthermore, the gel-like composition of the present invention spreads easily, making it easy to apply. Moreover, the gel-like composition can uniformly disperse solids, especially components that do not dissolve in water, such as powders and oil droplets of oil components. Therefore, for example, by adding gold powder or glitter, an aesthetic effect can be imparted.

〔Example〕

EXAMPLES Next, the present invention will be explained in more detail with reference to Examples.

In addition, the blending amount of each component in the examples is based on parts by weight, and if the blending amount is not the solid content amount, the solid content concentration is shown in parentheses after the component name. Also,(
n shown in parentheses after the component silk fibroin derivative a) represents the general formulas (1) to (I) representing the silk fibroin derivative.
In V), n represents the number of amino acids.

Example 1 A gel composition having the following composition was prepared.

Silk fibroin-inducing peptide 20 (n=8) Ethanol 30 total 100 Preparation was performed by dissolving the silk fibroin-inducing peptide in purified water, and adding ethanol to the solution while stirring and mixing.

Example 2 A gel composition having the following composition was prepared.

Silk fibroin-inducing peptide 25 (n, -, 5
) Ethanol 201.3-Butylene glycol 15 total 100 The preparation was carried out by dissolving the silk fibroin-derived peptide in purified water, and adding and mixing ethanol and 1,3-butylene glycol to the solution while stirring. Ta.

Example 3 A gel composition having the following composition was prepared.

Silk fibroin-inducing peptide 10 (n, = 10
) Glycerin 10 Ethanol
10+70 Total 100 Preparation was performed by first mixing glycerin, ethanol, and purified water, and adding and mixing the silk fibroin-derived peptide to the mixture while stirring.

Example 4 A gel composition having the following composition was prepared.

Silk fibroin-inducing peptide 4 (n=15) Silk fibroin-inducing peptide 6 (n=15)
Potassium salt of lauric acid condensate of propylene glycol 35 total 100 To prepare, dissolve silk fibroin-derived peptide and potassium salt of lauric acid condensate of silk fibroin-derived peptide in purified water, and add propylene glycol to the solution while stirring. This was done by adding and mixing.

Example 5 A gel composition having the following composition was prepared.

Silk fibroin-inducing peptide 5 (n=50)
trimethylammo-2-hydroxypropyl derivative ethanol 30 diglycerin 25
40 total 1
00 was prepared by dissolving a trimethylammonio-2-hydroxypropyl derivative of silk fibroin-derived peptide in purified water, and adding and mixing ethanol and diglycerin to the solution while stirring.

Example 6 A gel composition having the following composition was prepared.

Silk fibroin-inducing peptide 8 (n=10)
Ethanol 25 Sorbitol 8'7'59 Total 100 To prepare, first mix ethanol, sorbitol, and purified water, and add and mix the ethyl ester of silk fibroin-derived peptide to the mixture while stirring. went.

Example 7 A gel hair treatment having the following composition was prepared.

Silk fibroin-inducing peptide 8.0 (n=2
0) Ethanol 12.01.3-
Butylene glycol 5.0 Cetyltrimethylammonium chloride 0.3 nium polyoxyethylene (
0.2 10) Nonylphenyl ether methyl paraben 0.05 Fragrance
Appropriate amount of purified water Total amount: 100.00 Example 8 A gel skin treatment having the following composition was prepared.

Silk fibroin-inducing peptide 2.0 (n=5
) Silk fibroin-inducing peptide 5.0 (n-1
5) Benzyldimethylammonio 2-hydroxypropyl derivative ethanol 25.0 diglycerin 8.0 methylparaben
0.3 propylvarachen
0.03 fragrance Appropriate amount of purified water Total amount: 100.00 Example 9 An aqueous gel cream rinse having the following composition was prepared.

Silk fibroin-inducing peptide 5.0 (n=1
5) 1.3-Butylene glycol 12.0 Ethylene glycol distear 2.0 Late isopropyl isostearate 1.0 Tocetanol 2.0 Polyether modified silicone 0.7 (manufactured by Toray Silicone Co., Ltd. 5H Cetyltrimethylammonium chloride 0. 3Nium chloride distearyldimethylamino 0.2Ammonium polyoxyethylene (10) 0.5Nylphenyl ether methylparaben 0.2Propylparaben 0.02Fragrance
Appropriate amount of purified water (Total: 100.00) (2) Measurement The gel strength of the nine types of gel compositions prepared in Examples 1 to 9 was measured. However, the gel compositions of Examples 7 to 9 were prepared as a gel hair treatment, a gel skin treatment, and an aqueous gel cream rinse, respectively.

The measuring machine is Rheome NRM- manufactured by Fudo Kogyo Co., Ltd.
Using a 201OJ model, using a disc-shaped adapter with a diameter of 1 cm, press it against the surface of the gel composition at a speed of 2c + n per second to penetrate to a depth of 2 am from the surface, and the maximum stress (g weight) at that time was measured and the gel strength was compared. The temperature at the time of measurement was 20°C. The measurement results are shown in Table 2. When using this measurement method, the maximum stress is approximately 100
It is judged to be gel-like with moderate gel strength in the range of ~700g weight.

Table 2 As shown in Table 2, the gel compositions of Examples 1 to 9 were:
All of them have a maximum stress within the range of 100 to 700 g weight, and are gel-like with appropriate gel strength.

The cosmetic effects of the gel compositions of Examples 7 to 9 were evaluated.

Test Example 1 Apply an appropriate amount of the gel composition of Example 1 to the hair after washing with shampoo and the skin after washing with cosmetic soap (skin on the arms) and spread it well. The feel of the coated area was evaluated using the following evaluation criteria. The evaluation was performed by 10 female panelists, and the evaluation results are shown in Table 3 as the average values of the 10 panelists.

Evaluation criteria: 5: Very good 4: Good 3X Average 2: Bad 1: Very bad Table 3 Evaluation values of hair and skin feel when the gel composition of Example 1 was not applied As shown in Table 3, the gel composition of Example 1 had a high evaluation value and had good cosmetic effects.

Test Example 2 An appropriate amount of the gel hair treatment of Example 7 was applied to hair after washing with shampoo and spread well, and the feeling of use at that time and the feel of the applied area 30 minutes later were evaluated in the same manner as Test Example 1. . The results are shown in Table 4 as the average values of 10 panelists.

Table 4 The evaluation value of the feel when the gel hair treatment of Example 7 was not applied was all 3, but as shown in Table 4, the gel hair treatment of Example 7 The evaluation value was high and the effect as a hair treatment was excellent.

Test Example 3 Example 8 was applied to the skin (arm skin) after washing with cosmetic soap.
An appropriate amount of the gel-like skin treatment was applied and spread well, and the feeling of use at that time and the feeling of the applied area 30 minutes later were evaluated in the same manner as Test Example 1! The results are shown in Table 5 as the average values of 10 panelists.

Table 5 43: When the gel skin treatment of Example 8 was not applied, the evaluation value of the feeling was 3 in all cases, but as shown in Table 5, the gel skin treatment of Example 8 The evaluation value was high and the effect as a skin treatment was excellent.

Test Example 4 Apply an appropriate amount of the aqueous gel cream rinse of Example 9 to the hair after washing with shampoo, spread it well, and evaluate the application area at that time and the feel of the applied area 30 minutes later in the same manner as Test Example 1. did. The results are shown in Table 6 as the average values of 10 panelists.

Table 6 The evaluation value of the feel when the aqueous gel cream rinse of Example 9 was not applied was all 3, but as shown in Table 6, the aqueous gel cream rinse of Example 9 The evaluation value was high, and the effect as a cream rinse was excellent.

Claims (1)

[Scope of Claims] 1. A gel composition comprising the following components (a) to (c): (a) a silk fibroin derivative, (b) an alcohol, and (c) water. 2. The silk fibroin derivative of component (a) is one of the following [1]-
The gel composition according to claim 1, which is at least one selected from the group consisting of [4]. [1] General formula (I): ▲There are mathematical formulas, chemical formulas, tables, etc.▼ (In the formula, R_1 is the side chain of various amino acids that make up the silk fibroin-derived peptide, and n is 3 to 100.) Silk fibroin-derived peptide [2] represented by general formula (II): ▲There are mathematical formulas, chemical formulas, tables, etc.▼ (In the formula, R_1 and n are the same as in the above general formula (I), and R_2 is a carbon It is an alkyl group having 1 to 21 carbon atoms, an alkenyl group having 1 to 21 carbon atoms, or a side chain of a resin acid.M
is H, Na, K or NH_4, monoethanolamine, diethanolamine, triethanolamine, 2-amino-2-methyl-1-propanol, 2-amino-2
- an acylated product of silk fibroin-derived peptide or a salt thereof [3] General formula (III): ▲ Numerical formula, chemical formula, table, etc. ▼ (In the formula, R_1 and n are the same as in the above general formula (I), and R_3, R_4, and R_5 are an alkyl group having 1 to 22 carbon atoms, an alkenyl group having 2 to 22 carbon atoms, or R_3
One or two of ~R_5 is an alkyl group having 1 to 22 carbon atoms or an alkenyl group having 2 to 22 carbon atoms,
The remainder is an alkyl group having 1 to 3 carbon atoms, a hydroxyalkyl group having 1 to 3 carbon atoms, or a benzyl group, and A is alkylene having 2 to 3 carbon atoms or hydroxyalkylene having 2 to 3 carbon atoms. Quaternary ammonium derivative of silk fibroin-derived peptide [4] General formula (IV): ▲There are mathematical formulas, chemical formulas, tables, etc.▼ (In the formula, R_1 and n are the same as in the above general formula (I). Yes, R_6 is a linear alkyl group having 1 to 18 carbon atoms,
An ester of a silk fibroin-derived peptide represented by: a branched alkyl group having 1 to 18 carbon atoms, a linear hydroxyalkyl group having 1 to 18 carbon atoms, or a branched hydroxyalkyl group having 1 to 18 carbon atoms. 3. The gel composition according to claim 1, wherein the alcohol component (b) is a monohydric or polyhydric alcohol having 1 to 10 carbon atoms. 4. The blending ratio of components (a) to (c) in the composition is (a
) The silk fibroin derivative of the component is 1 to 30% by weight, (
b) component alcohol is 5 to 70% by weight; (c
2. The gel composition according to claim 1, wherein water in component ) is 20 to 90% by weight.