JPH0334266Y2 - - Google Patents

Description

[Detailed Description of the Invention] (Industrial Application Field) This invention relates to an ultrafiltration device, and particularly to a filtration device with a small amount of residual filtrate.

(Prior Art) In recent years, ultrafiltration, which can filter out not only bacteria but also polymers such as proteins and pyrogens, has become widely used for sample preparation, and ultrafiltration membranes are already commercially available.

This ultrafiltration device has the advantage that isotopes with a short lifetime of several minutes to several tens of minutes can be manufactured at a place of use such as a hospital or research institute, and the synthesized labeled compound can be easily made into an intravenous drug.

However, commercially available filter membranes tend to curl up, making it extremely difficult to aseptically set them into a commercially available filtration device. Furthermore, conventional filtration devices using this filter membrane have a large amount of liquid remaining in the container, making them unsuitable for processing small samples of about 1 to 10 ml, such as short-lived radiopharmaceuticals. Of course, if a filter with a small diameter is used, the amount of remaining liquid will decrease in proportion to the square of the diameter, but it will take time for filtration, making it unsuitable for handling short-lived nuclides.

(Problems to be solved by the invention) This invention makes it easier to set up the filter membrane by providing an inner lid to temporarily suppress the filter membrane, and reduces the space under the filter membrane to improve the filtration device. The aim is to minimize the amount of residual filtrate inside the ultrafiltration system and to obtain an ultrafiltration device that can be used in a wide range of applications.

Structure of the idea A detailed explanation will be given below with reference to the drawings.

FIG. 1 shows a cross section of an example of a known filter device.
A pot-shaped filtration container 1 has a filtrate outlet 2 at the center of the bottom, a Teflon packing 3 is placed on the inner bottom of the container, a filter membrane 4 stacked with a support plate is placed on top of it, and an upper lid is placed. It is screwed at 5.

For this reason, the filtrate in the space below the filter membrane 4 has become a residual liquid due to the aerodynamic phenomenon.

FIG. 2 shows one embodiment of the filtration device of this invention. The filtration device supports a filter membrane and holds a filtration device main body 11 that performs filtration and a container that accommodates a filtrate,
It consists of an adapter 12 for attaching to the main body 11 at a fixed position.

As shown in an exploded perspective view in FIG. 3, the filtration device main body 11 is comprised of a shallow cylindrical main body bottom 13 having a Luer strip male 14, which is a filtrate outlet, at the center of the bottom surface, and a stainless steel mesh inside. A filter membrane 16 overlapped with a support plate 15 is housed, and the peripheral edge of this filter membrane is pressed and fixed with an inner lid 17. This inner lid is tightened with a fixing screw 18 at its tightening flange 17'.
The upper edge of the inner lid 17 is closed by screwing the upper lid 19, and the inside of the inner lid 17 forms a container for the filtrate. 20 is a sample inlet, 21 is a pressurized gas inlet for filtration, and 22 is an O-ring for sealing. These components are designed to withstand the high pressures applied for ultrafiltration.
Manufactured to withstand pressure of Kg/cm2 or ^more .

Figure 4 shows details of the bottom of the main body. The bottom part 13, which has an H-shaped cross section as a whole, has a fixing screw 18 on the upper inner surface.
A female thread 23 is provided on the bottom of the filtrate guide groove 2.
4 is formed as a V-shaped groove. Further, the groove 25 is a ring groove for the ultra-fine O-ring 22, and most of the ring 22 is inserted into this ring groove 25, and after tightening with the fixing screw 18, the support plate 15 is almost attached to the bottom surface. The amount of filtrate remaining below this support plate is extremely reduced.

A female thread 26 for attaching a positioning adapter 12, which will be described later, is provided on the inner periphery of the lower surface, and a male Luer slip 14 is provided in the center to fit an injection needle 27 for introducing the filtrate into a vial.

The adapter 12 includes a bottle holding part 29 that fits and holds a vial bottle 28 that stores a filtrate therein, and a movable part 30 that is screwed onto the screw 26 and positions the bottle holding part 29 with respect to the filter main body. This ensures that the injection needle 27 is inserted accurately into the center of the cap of the vial. 31 is a photoelectric switch for detecting filtrate dripping.

Effects of the invention Since this invention has the above-mentioned configuration, the filter membrane 16 can be held down by the inner lid 17 and shaped with sterile tweezers, etc., and then screwed in with the fixing screws 18. It has now become possible to set it easily, without failure, and aseptically.

The filter membrane 16 and the support plate 15 are
Since the O-ring 22, which is almost submerged in the ring groove 25, is pressed and tightly attached to the bottom surface of the main body, the amount of filtrate remaining in the main body after filtration is completed is extremely small.

It has remarkable effects such as

[Brief explanation of drawings]

FIG. 1 is a sectional view of a conventional ultrafiltration device, and FIG. 2 is a partial sectional view of the entire ultrafiltration device of this invention.
Figure 3 is also an exploded perspective view of the filtration device main body, Figure 4
The figure is a detailed view of the bottom of the main body. 1: Filtration container, 3: Packing, 4, 16: Filter membrane, 5: Top lid, 11: Filtration device main body, 12: Positioning adapter, 13: Main body bottom, 15: Support plate,
17: Inner lid, 18: Fixing screw, 19: Upper lid, 2
0: Sample introduction port, 21: Pressurized gas introduction port, 22:
O-ring, 25: O-ring groove, 27: Syringe needle, 2
8: Vial bottle, 29: Bottle holding part, 30: Movable part, 31: Photoelectric switch.

Claims (1)

[Scope of utility model registration request] The bottom of the filtration device main body has a filtrate outlet in the center of the bottom, the support plate and filter membrane are placed on the O-ring placed in the O-ring groove provided in the bottom, and the flange at the lower end is placed on the O-ring. An ultrafiltration device comprising: a cylindrical inner lid that holds down a filter membrane; a fixing ring that engages with the bottom of the main body to press and tighten the inner lid to the bottom; and an upper lid that is fixed to the inner lid.