JPH03200714A - Composition for oral cavity application - Google Patents

Abstract

PURPOSE:To provide the subject composition for oral cavity application, containing an N-acylamino acid salt and a glucose fatty acid ester, having excellent foamability and taste and exhibiting excellent feeling to the palate. CONSTITUTION:The objective composition is produced by using (A) <=0.5wt.% of an N-acylamino acid salt (e.g. N-lauroyl glutamate sodium salt) and (B) 0.1-10wt.% of a glucose fatty acid ester containing 8-14C acyl group (e.g. glucose monocaprylate) as essential components and properly compounding with surfactant, abrasive, humectant, binder, sweetener, perfumery and drug component. The composition can be used in the form of tooth paste, wet dentifrice, liquid dentifrice, mouth wash, cleaning agent fro denture, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an oral composition that has good foaming properties, good taste, and has an excellent feeling of use.

[Prior Art and Problems to be Solved by the Invention] Oral compositions contain surfactants in order to enhance their cleaning power and provide a pleasant feeling when used. Surfactants used in such oral compositions have the effect of dispersing the oral composition during the day when used, and the effect of promoting the dispersion and penetration of medicinal ingredients in the oral composition. In addition to the effect of foam spreading inward, high safety is required, such as good taste and odor for use during the day, and extremely mild action on the oral mucosa.

Conventionally, surfactants used in oral compositions include:
Anionic surfactants such as alkyl sulfate ester salts, fatty acid monoglyceride sulfate ester salts, α-olefin sulfonates, N-acyl sarcosine salts, and nonionic surfactants such as sucrose fatty acid esters are used.

However, alkyl sulfate salts, fatty acid monoglyceride sulfate salts, α-olefin sulfonate salts,
All of them are found to be irritating to the oral mucosa, to varying degrees, and each has an unpleasant taste and odor. Furthermore, although the taste of N-acyl sarcosine salts is improved, there is a problem of oral mucosal peeling. Furthermore, although sucrose fatty acid esters exhibit very high safety, they have problems with foaming properties and taste.

It has also been known to use glucose fatty acid ester as a foaming agent for toothpaste (International Publication W088
However, the foaming properties of glucose fatty acid esters are still insufficient, and in particular, the glucose fatty acid esters described in this publication have a low monoester content and contain a considerable amount of diesters, tri- or higher polyesters. Because of this, there are problems with taste, foaming properties, etc.

Therefore, there is a need for a surfactant that can be used in oral compositions and not only has the original function of a surfactant to increase cleaning power, but also has high safety, foaming properties, and good taste.

[Means and effects for solving the problem] As a result of extensive studies in order to meet the above-mentioned needs, the inventors of the present invention have determined that glucose fatty acid ester having an acyl group having 8 to 14 carbon atoms should be added to 0.5 of the total composition. It has been found that it is effective to use N-acylamino acid salts in combination with weight percent or less.

That is, as mentioned above, N-acylamino acid salts have a good taste, but if used in large quantities, there is a problem of oral mucosal detachment, so the amount of N-acyl amino acid salts is usually limited to 0.5% (wt%, same hereinafter) or less. has been done. However, N-acyl amino acid salt is 0
．． Although the foaming properties are poor when the amount is about 5%, it is preferable to use the glucose fatty acid ester in combination with the N-acylamino acid salt, and in this case, it is preferable that the glucose fatty acid ester has one acyl group in one molecule. (In the present invention, monoester means a monoester having a monoester content of 90% by weight or more)
By using N-acyl amino acid salt, 0.5
It has been found that even in small amounts of less than %, the two act synergistically to provide excellent foaming properties, and the combined system of these two active agents has a good taste, and the amount of N-acylamino acid salt used can be reduced. It was discovered that high safety can be achieved by setting the content to 0.5% or less, leading to the present invention.

The present invention will be explained in more detail below.

The oral composition according to the present invention is prepared and applied as a toothpaste, a moist toothpaste, a liquid toothpaste, a mouthwash, a denture cleaner, etc., and is a combination of a glucose fatty acid ester and an N-acylamino acid salt. This is what happens.

Here, the glucose fatty acid ester used in the present invention is obtained from glucose and a fatty acid having 8 to 14 carbon atoms or a fatty acid derivative such as a lower alkyl ester thereof. Those with a carbon number smaller than 8 and those larger than 14 are undesirable because they have poor taste and foaming properties.

In this case, the raw material glucose is obtained by hydrolyzing naturally occurring glucose, starch from corn, potato, etc., and other polysaccharides using acids and enzymes.

It can be used after being decolorized and purified.

Examples of such substances include crystalline glucose, powdered glucose, and granular glucose defined by JAS.

On the other hand, 5-fatty acids include those with 8 to 14 carbon atoms, which include natural 2-synthetic, saturated, unsaturated, and linear 1-branched fatty acids.

They can be suitably used regardless of whether they are used singly or as a mixture. Further, as the lower ester of the fatty acid, an alkyl ester having 1 to 8 carbon atoms such as methyl, ethyl, and propyl of the above-mentioned fatty acids can be used, and a halogenated fatty acid can also be used as the raw material.

Glucose fatty acid ester is produced using these raw materials.
Methods such as ester synthesis using lipase, for example, transesterification reaction between raw oil and fat and glucose, transesterification reaction between lower alcohol esters of fatty acids and glucose, ester synthesis between fatty acids and glucose, and further using fatty acid chloride and glucose. It is preferable to synthesize by a synthetic method or various other known methods.

In this case, in the present invention, the glucose fatty acid ester has a monoester content of 90% or more, particularly 95%.
It is preferable to use the above glucose fatty acid esters in order to achieve the above-mentioned object of the present invention. In addition, the polyester content of triester or higher is 1% or less, especially 0.5
% or less, but the above-mentioned known methods all produce esters with a low monoester content and a high tri- or higher polyester content.

When obtaining a monoester, it may take time and effort to perform fractionation and isolation after synthesis. Therefore, in this respect, the method using heat-stable lipase, which was previously proposed by the present applicant in Japanese Patent Application No. 1-210495, is preferably adopted for the production of monoester.

In addition, as glucose fatty acid monoester, the following formula (H
Preferably.

(In the formula, R represents a residue of a saturated or unsaturated fatty acid having 8 to 14 carbon atoms.) Examples of such glucose fatty acid monoester include glucose monocaprylate, glucose monocaprate, glucose monolaurate, and glucose monolaurate. Examples include myristate, glucose sonoundecylenate, glucose mono-2-ethyl octanate, and the like.

In addition, in the present invention, one type of the above-mentioned glucose fatty acid ester may be used alone, or two or more types may be used in combination.

The amount of glucose fatty acid ester blended can be selected in various ways, but it is 0.1 to 10% of the total composition, especially 0.5%.
It is preferable to set it to 5%.

On the other hand, the N-acylamino acid salts used in the present invention include N-long chain acylamino acid salts, especially those having a saturated or unsaturated acyl group having 8 to 18 carbon atoms, specifically lauroyl group, myristoyl group. , a valmitoyl group, a stearoyl group, an oleoyl group, a coconut oil fatty acid residue, a hydrogenated beef tallow fatty acid residue, or a mixed fatty acid residue thereof, etc. are preferably used. In addition, there are no restrictions on the types of amino acids, but glutamic acid, sarcosine, N-methyl-
It is preferable to use β-alanine or the like alone or in combination of two or more. To illustrate, N-lauroyl glutamate, N-myristoyl glutamate, N-lauroyl sarcosinate, N-myristoyl sarcosinate, N-
Examples include sodium salt or potassium salt of lauroyl-N-methyl-β alaninate, and these salts can be used alone or in combination of two or more. The amount of N-acyl amino acid salt added is 0.5% or less.

If it is used in an amount exceeding 0.5%, it may cause peeling of the oral mucosa, which is not preferable.

In addition to the above-mentioned components, the oral composition of the present invention can contain various components depending on the type thereof.

For example, other surfactants, such as other anionic surfactants and fatty acid monoglycerides, as long as they do not impair the effects of the glucose fatty acid ester.

Nonionic surfactants such as fatty acid alkanolamide, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, amphoteric surfactants such as alkyl betaine, imidazolinium betaine, alkyl sulfobetaine, alkylamines Examples include semipolar surfactants such as oxides, and these 1
It can be used as a species or in combination of two or more species.

Furthermore, toothpastes contain abrasives such as dicalcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, aluminum hydroxide, and silicic anhydride, wetting agents such as glycerin, sorbitol, propylene glycol, and polyethylene glycol, and carboxymethyl cellulose. Sodium, carrageenan, sodium alginate, vegum, hydroxyethyl cellulose, xanthan gum, binders such as sodium polyacrylate, sodium saccharin, glycyrrhizin salts, stevioside,
Sweeteners such as paramethoxycinnamic aldehyde, neohesberidyl dihydrochalcone, perilartine, and flavoring agents such as menthol, carvone, and anethole are used.
Furthermore, if necessary, fluorides such as sodium monofluorophosphate, sodium fluoride, and tin fluoride, and tranexamic acid.

Medicinal ingredients such as anti-inflammatory agents such as ε-aminocaproic acid and allantoinate, and phosphoric acid compounds such as sodium phosphate are used as appropriate.

Further, other oral compositions may similarly be formulated with commonly used ingredients, and these oral compositions may be prepared according to conventional methods.

〔Effect of the invention〕

The oral composition according to the present invention uses the glucose fatty acid ester in an amount of 0.5% or less in combination with an N-acylamino acid salt, thereby providing an excellent cleaning effect, as well as excellent taste and foaming properties. Not only is it comfortable to use, but it is also highly safe.

Next, the effects of the present invention will be specifically explained using experimental examples.

[Experimental Example 1] Using the foaming agents (surfactants) shown in Table 1, a toothpaste composition having the following formulation was prepared by a conventional method. The foamability and taste of these toothpaste compositions were evaluated by the following methods. The results are shown in Table 1.

Reisho history alliance or Shufuyu (unit: %)
Dibasic calcium phosphate 45.0 Silicic acid anhydride 3.0 Sodium carboxymethyl cellulose 0.8 Carrageenan 0.2 Sorbiturate solution
26.0 Propylene glycol 3.0 Saccharin sodium
0.2 fragrance
1.0 blowing agent
Using the toothpaste composition prepared according to the above formulation, a toothpaste test was conducted by five well-trained expert panelists, and the foaming property was evaluated according to the following evaluation criteria. and taste was evaluated.

Foamability evaluation criteria O: Good foamability 0: Moderate foamability Δ: Slight foamability ×: Hardly foamy taste evaluation criteria O: Good (no bitterness) △: Slightly bitterness ×: Strong bitterness and unbearable use As shown in Table 1, the combined use of glucose fatty acid ester and N-acylamino acid salt was found to significantly improve foaming properties without adversely affecting taste. .

[Experimental Example 2] A toothpaste composition having the same formulation as Experimental Example 1 was prepared except that the foaming agent (surfactant) shown in Table 2 was used. The foamability and taste of these toothpaste compositions were evaluated using the same criteria as in Experimental Example 1. The results are shown in Table 2.

As shown in Table 2, all of the toothpaste compositions using a combination of glucose fatty acid ester and N-acylamino acid salt exhibited good foaming properties and taste.

Examples will be shown below, but the present invention is not limited to the following examples.

[Example 1] Toothpaste ingredients Weight % Aluminum hydroxide 40.0 Silicic acid anhydride 2.0 Propylene glycol 3.0 Sorbiturate solution 15.0 Glycerin 15.0 Sodium alginate 1.0 Saccharin sodium 0.2 Glucose 6-monolaurate 1.5N-sodium lauroylglutamate 0.5Fragrance
10 Preservatives Trace amount 100.0 [Example 2] Toothpaste ingredients Aluminosilicate Glycerin Sorbitol liquid Polyethylene glycol 400 Sodium carboxymethylcellulose Saccharin Sodium Glucose-6-monocaprate N-Lauroylsarcosine Sodium Flavor Color Plain purified water [Example 3 ] Toothpaste calcium carbonate (heavy) Calcium acid acid (light) Propylene glycol sorbitol liquid weight% 20, 0 15.0 40.0 4.0 1.2 0.2 1.0 0.5 1.0 Trace amount remaining Amount 30° 15° 3° 30° Sodium carboxymethylcellulose Saccharin Sodium Glucose tranexamate N-Myristoylmethyl-β-alanine Sodium Flavor Preservative 1.0 Trace glucose-6-monocaprylate N-Lauroylsarcosine Sodium allantoin chlorhydroxyaluminum flavor preservative [Example 5] Toothpaste 1.0 0.5 0, 1 1.0 Trace amount [Example 4] Toothpaste ingredients dibasic phosphate silicate anhydrous aluminum oxide propylene glycol sorbitol liquid carboxy Methyl cellulose sodium carrageenan saccharin sodium weight 45.

3.

1.

6 25.

O.

0.

0.

Zirconosilicate Polyethylene glycol silicic acid anhydride 400 Sorbitol solution Sodium carboxymethyl cellulose Sodium saccharin Glucose-6-monocaprylate Sodium N-lauroylmethyl-β-alanine β-Glycyrrhetinic acid Tocopheryl acetate 0,01 0,1 Fragrance color 1,0 Trace amount [Example 6] Moisturizing toothpaste ingredient dibasic calcium phosphate calcium carbonate glycerin carboxymethyl cellulose sodium saccharin sodium glucose-6-monolaurate N-myristoyl sarcosine sodium fragrance Weight 35.

40.

10.

0.

0.

1.

0.

1.

glycerin sorbitol liquid citric acid sodium citrate saccharin sodium Glucose-6-monocaprylate N-lauroysarcosine sodium fragrance

Claims (1)

[Claims] 1. An oral cavity composition comprising a combination of an N-acylamino acid salt and a glucose fatty acid ester whose acyl group has 8 to 14 carbon atoms in an amount of 0.5% by weight or less based on the total composition.