JPH0245896B2 - - Google Patents

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to reduced pressure blood collection tubes. Specifically, the present invention relates to a reduced pressure blood collection tube that has extremely high gas barrier properties, good transparency, and can maintain a high degree of reduced pressure for a long period of time. Prior Art The reduced-pressure blood sampling method is widely used because it produces specimens with less hemolysis and coagulation and less evaporation of contaminated water, and in terms of efficiency, it simplifies blood collection preparation and equipment management. Therefore, the vacuum blood collection tube used in such a vacuum blood collection system consists of a tubular container and a sealing rubber stopper that can be punctured. After that, the other end is punctured into the rubber stopper to communicate with the inside of the sealed container, thereby communicating with the inside of the container, whereby blood flows in due to the negative pressure inside the container and blood is collected. It is something that Conventionally, such vacuum blood collection tubes have been made of glass tubular containers, which have no gas transparency and good transparency, and butyl rubber stoppers, which have low gas permeability and can be punctured. Something more was used. However, glass tubular containers have the disadvantage that they are easily damaged during storage, transportation, or use, and are heavy. For this reason, the use of lightweight and transparent tubular containers made of synthetic resin is being considered; however, since synthetic resins are generally gas permeable, using synthetic resins as tubular containers for vacuum blood collection tubes will last a long time. During storage, ambient atmospheric gas, e.g. air, may permeate through the sealed vacuum blood collection tube through the tubular container, resulting in an increase in the pressure within the blood collection tube and the failure to achieve the desired vacuum blood collection. . The use of synthetic resins such as polyethylene terephthalate and polyvinylidene chloride, which are synthetic resins with fairly low gas permeability, is also being considered, but these resins have poor processability and are difficult to mold, and are difficult to mold into tubular containers. Even if it were possible, the gas barrier properties of the tubular container would not reach the desired value. For this reason, at present, a vacuum blood collection tube having a tubular container made of synthetic resin has not yet been put into practical use. OBJECT OF THE INVENTION Accordingly, an object of the present invention is to provide a novel vacuum blood collection tube. Another object of the invention is to
An object of the present invention is to provide a reduced pressure blood collection tube that has extremely high gas barrier properties, good transparency, and can maintain a high degree of reduced pressure for a long period of time. Still another object of the present invention is to provide a vacuum blood collection tube made of transparent synthetic resin that is free from breakage and has extremely high gas barrier properties. Still another object of the present invention is to provide a vacuum blood collection tube that is easy to process, inexpensive, and has an extremely high gas barrier property. These purposes consist of a tubular member with one end closed and the other end open, and a plug member that seals the open end of the tubular member and can be pierced. In a reduced pressure blood collection tube in which the internal space is maintained in a reduced pressure state, the tubular member contains 5 to 15% butadiene, 60 to 80% acrylonitrile, and 10 to 30% alkyl (meth)acrylate in polymerization ratios. This is achieved by a vacuum blood collection tube characterized by being molded from an acrylonitrile resin obtained by graft polymerizing butadiene rubber, acrylonitrile, and alkyl (meth)acrylate. The present invention further provides a vacuum blood collection tube in which the tubular member is made of an acrylonitrile resin obtained by graft polymerizing butadiene rubber, acrylonitrile, and methyl acrylate. The present invention also provides that the tubular member has a wall thickness of 0.2 to
This shows a 0.8mm vacuum blood collection tube.
The present invention also provides a vacuum blood collection tube in which the tubular member has ribs or beads. The present invention further provides a vacuum blood collection tube in which a blood coagulation promoting substance is attached to a portion of the inner surface of the tubular member. The present invention provides a vacuum blood collection tube in which the blood coagulation promoting substance is glass powder. The present invention further provides a vacuum blood collection tube in which the inner surface of the tubular member is coated with a blood clot-preventing substance.
The present invention provides a vacuum blood collection tube in which the blood clot adhesion preventing substance is water-soluble silicone. Specific Structure of the Invention Next, the present invention will be explained in detail with reference to the drawings. That is, as shown in FIG. 1, the reduced pressure blood collection tube 1 according to the present invention includes a transparent tubular member 2 with one end closed and the other end open, and a punctureable tube with the open end 3 of the tubular member 2 sealed. A plug member 4 is used to maintain a space 5 formed by the tubular member 2 and the plug member 4 in a reduced pressure state. Therefore, the present invention provides the tubular member 2 with butadiene-based rubber, acrylonitrile, and alkyl (meth) rubber.
It is characterized by being molded from an acrylonitrile resin made by graft polymerizing acrylate. The acrylonitrile resin has been modified by graft polymerization and not only exhibits extremely excellent gas barrier properties, but is also an amorphous resin with excellent transparency, gloss, and processability, as well as impact resistance and chemical resistance. It has very excellent properties such as properties, and also has the requirement of non-toxicity, which is an essential requirement for a material used for medical purposes. Examples of the alkyl (meth)acrylate monomers used include methyl acrylate, ethyl acrylate, n-butyl acrylate, isobutyl acrylate, 2-ethylhexyl acrylate, methyl methacrylate, ethyl methacrylate, n-propyl methacrylate, n
-butyl methacrylate, etc., preferably methyl acrylate and butyl acrylate, particularly preferably methyl acrylate.
As the other monomer, acrylonitrile is particularly preferred. In this acrylonitrile resin, the weight ratios of the respective monomers are 5 to 15% for butadiene, 60 to 80% for acrylonitrile, and 10 to 35% for alkyl (meth)acrylate, and the total sum is 100%. To mold the tubular member 2 with one end closed and the other end open using the acrylonitrile resin, various molding methods such as injection molding, blow molding, and vacuum forming can be used, but the workability and productivity are limited. From the viewpoint of product stability, blow molding methods, particularly injection blow molding methods and injection stretch blow molding methods, are preferred. Injection blow molding is performed as follows. For example, as shown in FIG. 6a, the neck mold 101 is closed,
Next, the core mold 102 and the cavity mold 103
is closed, and in this state, the molten acrylonitrile resin is injected from the nozzle 104 around the core mold 102 to form a parison 105. parison 105
Next, as shown in FIG. 6b, it is supported by the core mold 102, pulled out from the cavity mold 103, and transferred to the blow mold 106. After closing the blow mold 106 as shown in FIG. 6c, the air inlet 107 provided in the core mold 102 is opened as shown in FIG. 6d to suck in air and mold the tubular member 2 into the desired shape. do. After cooling, the neck mold 101 and the blow mold 106 are opened as shown in FIG. 6e, and the tubular member 2 is taken out. In addition, the injection stretch blow molding method is a method in which the material is stretched in the longitudinal direction with pins and then blown as shown in FIG. 6c. The tubular member 2 is molded in this manner, and the wall thickness of the tubular member 2 is usually 0.2 to 0.8 mm.
In other words, if it is less than 0.2 mm, there will be problems with strength, and if the inside is kept under reduced pressure, there is a risk of deformation due to external pressure, and if it exceeds 0.8 mm, it will not only increase costs but also require cooling during molding. This is not practical as it takes a long time. The tubular member 2 also has a second
Ribs or beads as shown in Figures 5 to 5 may be provided. The shape of the rib or bead is not particularly limited as long as it can reinforce the strength.
For example, there are various types such as ring-shaped ones as shown in Figures 2 and 3, ones inserted in the longitudinal direction of a tubular member as shown in Figure 4, or spiral ones as shown in Figure 5. In addition, the ribs or beads may be those that protrude inward from the tubular member as shown in Fig. 2, or those that protrude outwards as shown in Fig. 3, but from the viewpoint of product storage, It is best to have one that protrudes inward. In addition to vulcanized butyl rubber, the material constituting the plug member 4 may be one that allows a blood collection needle to be inserted during use and has sufficient elasticity to prevent the gap between the blood collection needle and the plug member from loosening due to the puncture of the blood collection needle. Furthermore, it is desirable that the material has low gas permeability. Typical examples thereof include, for example, a blend of a thermoplastic elastomer, polyisobutylene, and partially crosslinked butyl rubber. In this way, the vacuum blood collection tube 1 is obtained, but the tubular member 2 is made of the above-mentioned acrylonitrile resin, unlike glass, and has a weak effect of promoting blood coagulation. When used as a tube, as shown in FIG. 7, a part of the inner surface of the tubular member 2 is coated with a coagulation-promoting substance 6 such as glass powder, such as water-soluble silicone, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylamide, polyester, etc. Attach using an adhesive substance such as sodium acrylate. Further, in order to prevent blood clots from adhering to the tube wall, a blood clot adhesion prevention substance 7 such as water-soluble silicone may be applied to the inner surface of the tubular member 2. Further, the vacuum blood collection tube thus obtained is subjected to radiation sterilization before or after being sealed, if necessary. The radiation used includes electromagnetic radiation such as gamma rays and electron beams, preferably gamma rays, and the irradiation intensity thereof is 0.1 to 4 Mrad, preferably 0.5 to 2.5 Mrad. Specific Effects of the Invention The vacuum blood collection tube having the above configuration is used in the following manner. That is, as shown in FIG. 8, a vacuum blood collection tube 1 filled with a predetermined gas and maintained at a predetermined degree of vacuum is closed at one end and opened at the other end, and blood is collected into the screw hole 9 of the closed end 8. The needle 10 is inserted through the opening into the blood collection tube holder 11 to which the needle 10 is screwed. This blood collection needle consists of, for example, a blood vessel piercing part 10a and a plug puncturing part 10b, and the plug puncturing part 10b is wrapped with a rubber tip 12. Next, when the blood vessel piercing part 10a of the blood collection needle 10 is pierced into a blood vessel, for example, a vein, and the reduced pressure blood collection tube 1 is further pressed and inserted into the closed part 8 of the blood collection tube holder 11, the stopper of the blood collection needle 10 is removed as shown in FIG. The puncture part 10b punctures the rubber tip 12 and the stopper member 4, and the tip thereof reaches the internal space 5 of the blood collection tube 1, so that the blood vessel and the internal space 5 communicate with each other, and the negative pressure in the internal space 5 causes the blood vessel to close. The blood inside flows into the internal space 5 of the blood collection tube 1 in an amount corresponding to the degree of reduced pressure. Then, blood collection is completed by removing the blood vessel piercing portion 10a of the blood collection needle 10 from the blood vessel. Hereinafter, the present invention will be explained in more detail with reference to Examples. Example 1 As shown in Fig. 1, a tubular container with a wall thickness of 0.4 mm (inner capacity 12.0 ml) 2 with one end closed and the other end open.
The above acrylonitrile resin Barex
210 (manufactured by Mitsui Toatsu Chemical Co., Ltd.) by injection blow molding. On the other hand, a plug member 4 is made using vulcanized butyl rubber, and the opening end 3 of the tubular container 2 is made of vulcanized butyl rubber.
The tubular container was sealed with argon and the internal pressure was maintained at 150 mmHg. When the vacuum blood collection tube 1 thus prepared was tested for changes over time in the amount of blood collected after being left in the atmosphere, the results shown in Table 1 were obtained. Comparative Examples 1 to 2 The tubular container 2 is molded with polyethylene terephthalate (manufactured by Mitsui Petto Resin Co., Ltd., JO25) (Comparative Example 1), polystyrene (manufactured by Idemitsu Petrochemical Co., Ltd., HF-10) (Comparative Example 2) Except for this, a vacuum blood collection tube 1 was prepared in the same manner as in Example 1, and the same tests as in Example 1 were conducted. The results are shown in Table 1. The one made of polystyrene was made by injection molding and had a wall thickness of 1.0 mm.

[Table] Specific Effects of the Invention As described above, the reduced pressure blood collection tube of the present invention comprises a tubular member with one end closed and the other end open, and a plug member that seals the open end of the tubular member and is pierceable. A reduced pressure blood collection tube in which the internal space formed by the tubular member and the stopper member is maintained in a reduced pressure state, wherein the tubular member contains 5 to 15% butadiene and 60 to 80% acrylonitrile by weight. and an acrylonitrile resin obtained by graft polymerizing acrylonitrile and alkyl (meth)acrylate, and a butadiene rubber containing 10 to 30% of alkyl (meth)acrylate, so it has gas barrier properties. It is possible to provide an extremely excellent vacuum blood collection tube that is lightweight, resistant to breakage, and highly transparent, capable of maintaining a high degree of vacuum over a long period of time, and thus capable of performing blood collection under a specified vacuum. Furthermore, the acrylonitrile resin has excellent processability and can be easily injection blow molded, so that vacuum blood collection tubes with high dimensional accuracy can be provided at low cost and with good productivity. Furthermore, the mechanical strength and gas barrier properties of the acrylonitrile resin are extremely excellent, and it is sufficient if the wall thickness of the tubular member is 0.2 to 0.8 mm, resulting in a lightweight and economical vacuum blood collection tube. Furthermore, by providing ribs or beads on the tubular member to reinforce its strength, even a thin-walled vacuum blood collection tube can be further improved in its strength. moreover,
By attaching a blood coagulation promoting substance such as glass powder to a part of the inner surface of the vacuum blood collection tube, the vacuum blood collection tube can also be used for serum separation.
If a blood clot-preventing substance such as water-soluble silicone is applied to the inner surface of the tubular member, blood clots will not adhere to the tube wall even after sterilization using gamma rays.

[Brief explanation of the drawing]

FIG. 1 is a longitudinal sectional view of one embodiment of the reduced pressure blood collection tube of the present invention, FIGS. 2 and 3 are longitudinal sectional views of other embodiments of the reduced pressure blood collection tube of the present invention, and FIGS. 4 and 5 6a to 6e are schematic diagrams showing an example of a method for forming the tubular member of the vacuum blood collection tube of the present invention, and FIG. 7 is a diagram showing still another embodiment of the vacuum blood collection tube of the present invention. It is an enlarged vertical sectional view showing the aspect of
9 and 9 are longitudinal cross-sectional views showing the state in which the vacuum blood collection tube of the present invention is used. DESCRIPTION OF SYMBOLS 1... Decompression blood collection tube, 2... Tubular member, 3... Open end, 4... Plug member, 5... Internal space.

Claims (1)

[Scope of Claims] 1. Consists of a tubular member with one end closed and the other end open, and a plug member that seals the open end of the tubular member and can be pierced, and is formed by the tubular member and the plug member. In a reduced pressure blood collection tube in which the internal space is maintained in a reduced pressure state, the tubular member contains 5 to 15% butadiene and 60 to 80% acrylonitrile by weight.
% and alkyl (meth)acrylates from 10 to 35
1. A vacuum blood collection tube characterized in that it is molded from an acrylonitrile resin obtained by graft polymerizing a butadiene rubber containing acrylonitrile and an alkyl (meth)acrylate. 2. The vacuum blood collection tube according to claim 1, wherein the tubular member is made of an acrylonitrile-based resin obtained by graft polymerizing butadiene rubber, acrylonitrile, and methyl acrylate. 3. The vacuum blood collection tube according to claim 1 or 2, wherein the tubular member has a wall thickness of 0.2 mm to 0.8 mm. 4. The vacuum blood collection tube according to any one of claims 1 to 3, wherein the tubular member has a part of its inner surface protruding. 5. The vacuum blood collection tube according to any one of claims 1 to 4, wherein a blood coagulation promoting substance is attached to a part of the inner surface of the tubular member. 6. The vacuum blood collection tube according to claim 5, wherein the blood coagulation promoting substance is glass powder. 7 Claims 1 to 7, wherein the inner surface of the tubular member is coated with a substance that prevents blood clot adhesion.
The reduced pressure blood collection tube according to any one of paragraph 6. 8. The vacuum blood collection tube according to claim 7, wherein the blood clot adhesion preventing substance is water-soluble silicone.