JPH02273603A - Spray solution containing isothiocyanic ester and injection equipment containing the same - Google Patents

Abstract

PURPOSE:To obtain the subject spraying solution containing an isothiocyanic ester of a specified concentration, having a highly quickly acting nature of anti fungal effect, freshness-preserving effect and deodorizing effect, due to the direct contact with the objectives by such droplet form. CONSTITUTION:The objective spray solution can be obtained by dissolving an isothiocyanic ester in an organic liquid (esp. pref. ethanol or aqueous ethanol). Practically, an injection equipment is used, which is such that said spray solution has been encapsulated under pressure together with a jetting agent into a closed vessel equipped with a jet nozzle. Low concentration will be enough since the present solution is sprayed in the form of droplets against objects. Thereby the sharp irradiating odor of said ester can be suppressed, resulting in no deterioration of the environment. The present solution can be applied to the food field, therapies for skin disease, etc., taking advantage of its anti-fungal nature, freshness retentivity, deodorizing ability, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a spray solution containing an isothiocyanate ester and an injection device containing the same.

(Prior art and its problems) It has been known from experience that wasabi has antibacterial, antifungal, and anticorrosive effects.6 However, isothiocyanate, which is the main component of wasabi, is an active ingredient. Industrial agents such as antibacterial agents, antifungal agents, and freshness-preserving agents have not yet been developed.This is because isothiocyanate esters are difficult to handle substances that give off a strong pungent odor, and are highly volatile. This is thought to be due to

In order to make isothiocyanate esters easier to handle, the applicant proposed a drug in which clay minerals with a fibrous crystal structure such as seviolite are impregnated with isothiocyanate esters (Japanese Patent Application No. 63-267661). ), this drug has a suppressed volatility of isothiocyanate ester due to the fibrous crystal structure of the clay mineral, and gradually evaporates the isothiocyanate ester over a long period of time, and the volatilized isothiocyanate ester By bringing the vapor into contact with an object, it obtains antibacterial, antifungal, and anti-rot properties.

However, since this drug uses the vapor of isothiocyanate ester, sufficient effects cannot be obtained unless it is used in a closed system.

(Problems to be solved by the invention) The present invention aims to improve the antibacterial effect of isothiocyanate ester droplets by bringing them into direct contact with an object.

The object of the present invention is to provide a spray solution and an injection device for obtaining antifungal, freshness preserving, and deodorizing effects.

(Means for Solving the Problems) The present inventors have conducted extensive research to solve the above problems, and as a result, have completed the present invention.

That is, according to the present invention, a spray solution is provided in which an isothiocyanate ester is dissolved in an organic liquid at a concentration of 0.01 to 5% by weight.

Further, according to the present invention, there is provided an injection device in which the spray solution is pressurized and sealed together with a propellant in an airtight container provided with an injection nozzle.

The antibacterial action as used herein refers to bactericidal action and bacteriostatic action against various bacteria such as aerobic bacteria and anaerobic bacteria.

It means antibacterial effect, etc. The anti-mold effect refers to the effect of preventing the growth of mold on various solid surfaces such as glass and concrete walls, as well as on food. The freshness-preserving effect refers to the effect of preventing mold from forming on food, preventing spoilage and fermentation of food, and preventing deterioration of freshness. Furthermore, its deodorizing effect eliminates bad odors such as those caused by food spoilage (amine odor) and bad odors caused by bacterial decomposition of lipids (lower fatty acid odor such as isovaleric acid, sulfur compound odor such as indole, etc.). It means odor effect or deodorizing effect. It is an unexpected fact discovered by the present inventors that isothiocyanate esters have a deodorizing effect on bad odors.

Various esters of isothiocyanic acid are used as the isothiocyanic acid humble ester in the present invention, but preferably isothiocyanic acid allyl ester (CH,=CH
CH, NC3) and isothiocyanic acid alkyl esters (RNC3%R: alkyl group) are used.

In the present invention, currant oil can be used as it is.

In the present invention, the isothiocyanate ester is dissolved in an organic liquid to form a spray solution. In this case, the concentration of isothiocyanate ester in the spray solution is usually 0.01 to 5 wt.

By creating a solution with such a low concentration, volatilization of the isothiocyanate ester is suppressed, making it easier to handle, and when this solution is sprayed, the strong irritating odor of the isothiocyanate ester is not emitted into the surrounding environment. Prevented.

Any organic liquid can be used as long as it is compatible with the isothiocyanate ester.

Such organic liquids include various alcohols such as monohydric alcohols such as ethanol, propatool, butanol, octyl alcohol, and oleyl alcohol, and polyhydric alcohols such as ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, and glycerin. In addition, various oil-based liquids can be used. Examples of oily liquids include olive oil, sesame oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, castor oil, sunflower oil, cottonseed oil, peanut oil, cacao butter, palm oil, clove oil, and coconut oil. , fats and oils such as beef tallow, fish oil, hydrogenated oil, turd oil, and egg yolk oil; waxes such as liquid lanolin; hydrocarbon oils such as liquid paraffin, liquid polyisobutylene, and soufflen; high-grade oils such as oleic acid, linoleic acid, and ricinoleic acid. Fatty acid oils include ester oils such as vinegar-brewed lanolin and hexyl laurate.

As the oily liquid, it is preferable to use one that is odorless or nearly odorless.

A preferred organic liquid for use in the present invention is ethanol or aqueous ethanol. In the case of aqueous ethanol, considering the solubility of isothiocyanate esters, the upper limit of water content should be 50% by weight or less. Ethanol itself has strong antibacterial and antifungal properties, so its use is very preferable. When using ethanol as an organic liquid for dissolving isothiocyanate esters, it is preferable to add and mix a non-volatile liquid in order to control the transpiration of the adhering solution when the solution is sprayed onto the object. can. Such a hardly volatile liquid has a temperature of 150°C or higher, preferably 1
Those having a boiling point of 80°C or higher are used. Examples of such a hardly volatile liquid include the above-mentioned polyhydric alcohols and oily liquids. The amount of the hardly volatile liquid added is generally 10 to 100 parts by weight per 100 parts by weight of ethanol, but is not particularly limited.

The spray solution of the present invention optionally contains a surfactant,
Auxiliary components such as polymeric substances, viscosity modifiers, antioxidants, finely powdered adsorbent particles, etc. can be added.

The spray solution of the invention is placed in a suitable spray device and
A preferred spray device used in the present invention, which is used to eject droplets from its nozzle, is of the aerosol type using a propellant. That is, to obtain an aerosol type injection device using the spray solution of the present invention, the spray solution is placed in a closed container equipped with an injection nozzle.

The propellant may be press-injected, and the propellant may be a conventionally known propellant, such as a liquefied hydrocarbon gas, such as propane, n
-butane, isobutane, n-pentane, isopentane or mixtures thereof are used.

Generally, liquefied petroleum gas or liquefied natural gas is preferably used. Further, a fluorocarbon gas such as fluorodichloromethane can be used.

(Effects of the Invention) The spray solution containing the isothiocyanate ester according to the present invention is used by spraying it onto an object as droplets. in this case.

Since isothiocyanate ester is ejected in a low concentration solution state, the strong irritating odor caused by isothiocyanate ester is suppressed and does not particularly deteriorate the surrounding environment. Since it comes in contact with the liquid in liquid form, it is much more effective than contacting it in vapor form.

The spray solution of the present invention utilizes the antibacterial, antifungal, freshness-retaining, and deodorizing properties of isothiocyanate esters to be used in various fields where the proliferation of harmful microorganisms is a problem, including the food field, and in various fields where the proliferation of harmful microorganisms is a problem. It is widely used in various fields of concern. In addition, isothiocyanate ester is
The present inventors have discovered that the spray solution of the present invention has an antibacterial effect against bacteria such as A. It can be used for purposes such as treatment.

(Example) Next, the present invention will be explained in more detail with reference to Examples.

Example 1 A spray solution was obtained by dissolving allyl isothiocyanate at a ratio of 0.5% by weight in 9 parts of ethanol.

Next, 300 g of this solution was filled into an aerosol can with an internal volume of 500 d, and a propellant (liquefied butane) was further filled at an angle of 80° to obtain an injection device. When the solution was injected from the injector thus obtained, it was confirmed that the solution turned into atomized particles and was clearly atomized. Furthermore, during this eruption, the strong irritating odor caused by allyl isothiocyanate was significantly suppressed, and it was confirmed that it did not particularly worsen the surrounding environment.

Next, when the solution was sprayed into the airtight container containing the cut mochi using the spraying device and the lid was closed, no mold growth was observed even after one month. In an experiment in which no solution was sprayed for comparison, mold was already observed on the surface of the cut mochi on the third day.

Example 2 100 parts by weight of soybean oil was added and mixed to 100 parts by weight of a 1% by weight ethanol solution of allyl isothiocyanate to obtain a spray solution. This solution was filled into an aerosol can in the same manner as in Example 1, and a propellant was further filled to obtain an injection device. When the solution was injected using the injector thus obtained, it was confirmed that the solution could be injected well.

Furthermore, during this injection, the irritating odor caused by allyl isothiocyanate was further suppressed compared to the case of Example 1.

Patent applicant: Minato Sangyo Co., Ltd.

Claims (4)

[Claims] (1) A spray solution prepared by dissolving isothiocyanate ester in an organic liquid at a concentration of 0.01 to 5% by weight. 2. The spray solution of claim 1, wherein the organic liquid is ethanol or aqueous ethanol. (3) The spray solution according to claim 1, wherein the organic solution is ethanol or a mixture of aqueous ethanol and a hardly volatile liquid. (4) An injection device comprising the spray solution according to any one of claims 1 to 3 and a propellant sealed in an airtight container equipped with an injection nozzle under pressure.