JPH02237559A - Implant member for living body and preparation thereof - Google Patents

Abstract

PURPOSE:To strongly bond a base material layer and a metal mesh by scattering and bonding a metal powder of the same kind to the surface of the base material layer of a metal implant member. CONSTITUTION:A metal powder 5 of the same kind is scattered and bonded to the surface of the base material 2 of a metal implant member to form a powder layer 5A. A metal mesh 3 of the same kind is added to this powder layer 5A and heated to be diffused-in and bonded to said layer 5A. The metal mesh 3 is bonded to the base material 2 through the powder 5 and the base material layer can be strongly bonded to the metal mesh.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to an implant member such as an artificial bone or an artificial tooth root to be implanted in a living body, and a method for manufacturing the same, and in particular, it relates to an implant member that can be firmly bonded to living tissue. The present invention relates to a living body implant member configured as described above and a method for manufacturing the same. In the following description, a biological implant member made of pure titanium or a titanium alloy will be described, but the present invention does not limit the material of the implant member.

[Prior art] Damaged or missing human bones. When prosthetizing joints, teeth, etc., metal or ceramic artificial bones, artificial joints,
Biological implant components such as artificial tooth roots are used. In particular, implant members made of pure titanium or titanium alloy (hereinafter simply referred to as titanium), which are excellent in light weight and corrosion resistance, have come to be used frequently.

FIG. 3 is an explanatory view showing an example of a titanium artificial bone 1 for femur, which is composed of a head portion 1a and a stem portion 1b.

If the surface of the artificial bone l, especially the surface of the stem portion 1b, is formed smooth, the bonding force with the living tissue is weak, and even if it is embedded and fixed in the bone marrow of the remaining bone, it may easily come out. , or may cause misalignment. Therefore, in order to form fine irregularities on the surface of the base material 2 in the artificial bone 1, a titanium mesh 3 is attached to the surface of the base material 2, or a titanium wire 4 is wound around the surface of the base material 2. is being carried out. When the irregularities are thus formed on the surface of the base material 2, the new living tissue enters the recesses and grows to take root, and the artificial bone 1 and the living body are firmly joined by the anchor effect.

[Problems to be Solved by the Invention] In bonding the mesh 3 onto the base material 2, a method of heating and diffusion bonding is commonly used, but as shown in FIG. 3 joint is P. ,P
2, the bonding area is only 2 to 3% per unit area of the base material 2, and the mesh 3 is connected to the base material 2.
It could not be said that it was firmly bonded to the surface. Therefore, even after the new biological tissue has entered the recess formed by the mesh 3, if a large load is applied, the mesh 3 itself may peel off from the base material 2, causing the artificial bone 1 to become misaligned. . That is, the adhesion force of the undercut forming member itself, which should serve as a base for exerting the anchor effect, was weak. Although it has been devised to use a fine mesh to increase the number of point contacts, there are also restrictions from the perspective of achieving invasive growth of bone tissue (described later), and there are limits to the selection of a fine mesh. be.

Therefore, the present inventors conducted extensive research and completed the present invention with the aim of providing a biomedical implant member in which the surface roughening mesh itself is firmly bonded to the base material surface, and a method for manufacturing the same.

[Means for Solving the Problems] The living body implant member of the present invention that has achieved the above object is a living body implant member in which a metal mesh of the same type is attached to the surface of the base layer of a metal implant member. The gist lies in that the same kind of metal powder is dispersed and bonded to increase the bonding force between the base material layer and the metal mesh, and as a means for manufacturing such an implant member. Two methods are disclosed.

The first manufacturing method is to scatter the same type of metal powder on the surface of the base material layer of a metal implant member, place a metal mesh of the same type on the sprinkled powder layer, and heat it to perform diffusion bonding. Yes, and the second manufacturing method is to attach a metal mesh of the same type to the surface of the base material layer of a metal implant member,
Next, metal powder of the same type is sprinkled on top of it, and then heated and diffusion bonded.

[Operations and Examples] FIGS. 1(a) to 1(C) are explanatory diagrams showing an example of the manufacturing process of the biological implant member of the present invention, and this example is
The manufacturing method is shown below. First, in FIG. 1(a), titanium powder 5 (hereinafter simply referred to as powder 5) is sprinkled on the surface of a base material 2 such as a titanium artificial bone or an artificial tooth root to form a powder layer 5A.

The particle size of the powder 5 is not particularly limited, but it is generally preferable to use a particle size of about 150 μm or less, and it is attached to the surface of the base material 2 by a plasma spraying method, a sintering method, etc. A powder layer 5A having a thickness of preferably about 100 μm to 200 μm is formed. Next, as shown in FIG. 1(b), a titanium mesh 3 is placed on the powder layer 5A, and the mesh 3 is heat-treated while being pressed so as to apply a load from above to perform diffusion bonding. In this diffusion bonding, the base material 2 and the mesh 3 are welded together with the powder 5 interposed therebetween. The heat treatment temperature at this time is not particularly limited, but depends on the titanium material used.
Select an appropriate temperature within the range of ~1300°C. Note that the time for this heat treatment is preferably 30 minutes or more in order to obtain reliable bonding.

As a result, as shown in FIG. 1(C), the mesh 3 is bonded to the base material 2 through the powder 5, and the bonding area between the mesh 3 and the base material 2 is now through the powder layer 5A. It was confirmed that the amount increased by about 10 to 15% per unit area in the example, and the bond between the mesh 3 and the base material 2 became extremely strong.

In this way, it has become possible to firmly bond the mesh 3 to the surface of the base material 2, which frees us from the effort to make the mesh spacing as narrow as possible.
The range of choices from the viewpoint of selecting the optimal mesh spacing for the invasive growth of biological tissue has been expanded.

That is, human bone tissue is said to consist of unit tissues of 100 to 500 μm, so in order to make it easier for new bone tissue to enter into the recesses on the surface of the artificial bone, the mesh 3
The mesh spacing is preferably 100 to 1000 μm, more preferably 200 to 500 μm, and even when using the mesh 3 with such a relatively large mesh size, the mesh and This made it possible to maintain high bonding strength between the base materials.

The material from which the mesh 23 is formed is not particularly limited, but for example, when a filament with a round cross section is used, half of the mesh in the thickness direction in the concave space between the filaments becomes a shape that widens toward the base material 2 side. After the new biological tissue has entered, the artificial bone can be firmly fixed by the anchoring action.

Therefore, it is at the discretion of the person implementing the present invention to select various materials from this point of view.

FIGS. 2(a) to 2(c) are explanatory diagrams illustrating the second manufacturing method of the present invention. As shown in FIG. 2(a), the mesh 3 is temporarily attached to the surface of the base material 2 by spot welding, and the mesh 3 is heated while being pressed from above to perform diffusion bonding as in the conventional method. Next, as shown in FIG. 2(b), the powder 5 is sprinkled from above the mesh 3 and the base material 2, and further heat treatment is performed to assist the bonding of the mesh 3 to the surface of the base material 2 by welding of the powder 5. The powder 5 may be applied by a plasma spraying method, or the powder 5 may be applied so as to be spread over the space between the mesh 3 and the base material 2 or the corners of the mesh, It may also be a method of welding it to the mesh 3 or the base material 2 by then heat-treating it. As a result, the mesh 3 can be firmly bonded to the surface of the base material 2 via the powder 5, as shown in FIG. 2(C). Note that the manufacturing method shown in FIGS. 1 and 2 may be used in combination, and the powder 5 may be spread before and after the mesh 5 is arranged.

In the implant member manufactured by the manufacturing method as shown in FIGS. 1 and 2 above, the base material 2 and the mesh 3 are firmly bonded via the powder 5, and there is no risk of peeling of the mesh 3 from the base material 2. can be almost completely prevented.

In the above embodiment, an example was shown in which the mesh 3 is diffusion bonded to the outside of the base material 2, but when using the wire 4 instead of the mesh, the same manufacturing method can be applied to the wire 4. can be firmly bonded to the outer surface of the base material 2. Therefore, in the case of a wire, there are no restrictions on bonding performance, and therefore no problem will arise even if the wire diameter of the wire 4 is arbitrarily selected.

Furthermore, the materials of the base material 2, powder 5, and mesh 3 may be any combination as long as they are the same kind of metal materials. For example, as in the example described below, pure titanium and titanium alloy may be combined In addition to the titanium material mentioned above, stainless steel, cobalt alloy, etc. may also be used. (Experimental Example 1) Pure titanium powder (JIS Class 2) with a grain size of 44 μm or less was plasma sprayed onto a base material made of Ti-6AI-4V alloy, and a wire with a wire diameter of 0.3 mm and a mesh spacing was A 350 μl pure titanium (JIS type 1) mesh was coated and diffusion bonding was performed under the following conditions.

[Diffusion bonding conditions] Under a vacuum of 4 x 10-'Torr, pressing was applied from the outside of the mesh at a pressure of 1 kg/cm2, and treatment was performed at a temperature of 950°C for 3 hours.

In addition, the plasma spraying described above is carried out at 1×10-3T inside the vacuum chamber.
The pressure was reduced to or below and the test was carried out under a dilute argon gas atmosphere.

(Experimental Example 2) Using the same materials as in Experimental Example 1, a mesh was first diffusion bonded to the surface of the base material under the same conditions, and after plasma spraying pure titanium powder thereon, heat treatment was performed again.

In the implant member obtained in Experimental Example 1.2 above, the mesh becomes firmly bonded to the base material, and the bonding strength is improved by about 5 times compared to that manufactured by the conventional method. I was able to do that. [Effects of the Invention] In the biological implant member of the present invention configured as described above, the base material surface and the mesh are firmly bonded via the metal powder over a wide bonding area, and the biological tissue is It no longer peels off easily when it grows intrusively and exerts an anchor effect. Furthermore, it has become possible to easily manufacture such implant members by utilizing mesh and wire.

[Brief explanation of drawings]

FIGS. 1(a) to (c) are explanatory diagrams showing the steps of the first manufacturing method of the present invention, and FIGS. 2(a) to (C) are explanatory diagrams showing the steps of the second manufacturing method of the present invention. FIG. 3 is an explanatory view showing an example of an implant member, and FIG. 4 is an explanatory cross-sectional view showing an example of conventional joining of a mesh and a base material. l...Artificial bone 2...Base material 3...Mesh 4...Wire 5...Metal powder

Claims (3)

[Claims] (1) In a biological implant member in which a metal mesh of the same type is attached to the surface of a base layer of a metal implant member, metal powder of the same type is spread and bonded to bond the base layer and the metal mesh. A living body implant member characterized by having increased bonding strength. (2) For biological use, characterized in that metal powder of the same type is sprinkled on the surface of the base material layer of a metal implant member, and a metal mesh of the same type is placed on the sprinkled powder layer and heated and diffusion bonded. Method for manufacturing implant components. (3) For biological use, which is characterized in that a metal mesh of the same type is attached to the surface of the base material layer of a metal implant member, and then metal powder of the same type is sprinkled on top of the mesh, followed by heating and diffusion bonding. Method for manufacturing implant components.