JPH02173570A - Automatic chemical analyzer - Google Patents

Abstract

PURPOSE:To obtain the automatic chemical analyzer being concise and unbulky and to increase its processing capacity by providing a first and a second reaction lines so that a measuring instrument can be used in common for the first and second reaction lines. CONSTITUTION:A first reaction line 4 and a second reaction line 5 are provided in parallel, measuring containers and reaction containers 3 arranged in the line 4 are positioned and placed in positions of the line 4 corresponding to between arranged positions of measuring containers and reaction containers 3 arranged in the line 5, respectively, and also, by placing the line 4 and the line 5 between, an optical member 26 of a light source side of a measuring instrument and an optical member 27 of a photodetection side corresponding thereto are provided in an optical arrangement, therefore, the line 4 and the line 5, for instance, are used simultaneously for an analysis line, or one of them and the other are used for the analysis line and a cleaning line, respectively, and also, the line 4 and the line 5 are used for an analysis of each different specific analysis item, and many analytical processings can be executed as a general puspose automatic chemical analyzer having a large processing capacity.

Description

Detailed Description of the Invention (a) Industrial Application Field The present invention relates to an automatic chemical analyzer equipped with a sample dispensing device, a reagent dispensing device, a washing/dehydrating device, and a measuring device, and in particular,
Sample dispensing device for multiple reaction lines, reagent dispensing nozzle,
The present invention relates to an automatic chemical analysis device including a reagent dispensing device including the nozzle cleaning device and the reagent tray, a cleaning dehydration device, and a measuring device.

Further, the present invention can be applied to, for example, body fluids such as blood, plasma, serum, and lymph, excreta such as urine, secretions such as gastric juice, pancreatic juice, bile, saliva, and sweat, and puncture fluids such as ascites, pleural effusion, and joint cavity fluid. The present invention relates to a support device for a measurement container/reaction container in an automatic chemical analyzer for liquid samples such as specimens.

(b) Conventional technology For example, in a discrete automatic chemical analyzer such as a turntable type or a conveyor type, a turntable or conveyor device that can be moved intermittently, a sample dispensing device, a reagent dispensing device, and a cleaning device are used. and a measuring device.

When analyzing multiple samples using such an automatic chemical analyzer, for example, in the case of a turntable type, multiple reaction cuvettes, etc. are placed along the reaction line formed on the turntable. By arranging the containers and rotating the turntable intermittently or continuously according to a preset time program, each of the plurality of reaction containers can be sequentially controlled, for example, in a sample dispensing area, a reagent dispensing area, and stirring. When the turntable is stopped, the sample dispensing area, the reagent dispensing area, the stirring area, the reaction area, the measurement area, and the washing area are transferred in the order of the sample dispensing area, the reaction area, and the cleaning area. A predetermined amount of sample is dispensed by the sample dispensing device in the dispensing area, a predetermined amount of reagent is dispensed by the reagent dispensing device in the reagent dispensing area,
Samples and reagents are stirred in the stirring area, predetermined analytical reactions are carried out in the reaction area, absorbance of analysis item components is measured using the rate method or end point method in the measurement area, and the measurement has been completed in the washing area. Performs various analysis operations, such as cleaning reaction vessels.

The reaction vessels that have undergone analysis operations in this way are then sent to the next stopping position by intermittent or continuous rotation of the turntable, and the reaction vessels located in each area are
Same as last time, sample dispensing, reagent dispensing, stirring, reaction,
Each analytical operation of measurement and cleaning is performed, and the drive of the turntable and the analytical operation in each area are continuously repeated to perform analysis on a plurality of samples.

(c) Problems to be solved by the invention Although the number of samples to be analyzed in such an automatic chemical analyzer is limited, for example, the number of analysis items per sample analyzed by biochemical analysis method is The number of samples being analyzed is increasing significantly in order to improve diagnostic accuracy, and the number of samples being analyzed is not limited to patients but also healthy people. , it is desired to increase the analytical processing Fl capacity per unit time of an automatic chemical analyzer.

In order to meet such demands, for example, in the conventional single multi-method, the number of reaction vessels has to be increased, resulting in an increase in the size of the reaction table, which poses a problem. This is a problem because the cleaning process is not carried out sufficiently, which impairs the accuracy of the analytical values.

In addition, in the conventional method of installing multiple reaction lines in parallel, even if the number of lines is increased to increase processing capacity,
Because it is necessary to install a measuring device on each line,
It is unavoidable that the device becomes larger and more complicated, and the adjustment of measurement errors between measuring devices becomes complicated, which is a problem.

An object of the present invention is to solve the problems associated with increasing the processing capacity of such conventional automatic chemical analyzers.

(d) Means for Solving the Problems The present invention provides a first and second reaction line so that the measuring device can be shared by the second and second reaction lines, thereby reducing the complexity and processing capacity. The aim is to provide a large automated chemical analyzer.

That is, the present invention provides an automated system in which a plurality of reaction containers are arranged to form a reaction line, and a sample dispensing device, a reagent dispensing device, a measuring device, and a cleaning device are provided around the reaction line. In a chemical analyzer, a first reaction line and a second reaction line are arranged in parallel, and the measurement vessels/reaction vessels arranged in the first reaction line are the measurement vessels/reaction vessels arranged in the second reaction line, respectively. The light source side member and the corresponding light receiving side member of the measurement device are arranged at the corresponding first reaction line position between the arrangement positions of the containers, and the light source side member and the corresponding light receiving side member of the measurement device are connected to each other with the first reaction line and the second reaction line in between. The automatic chemical analyzer is characterized in that it is provided in a strategically arranged arrangement.

In the present invention, in the first and second reaction lines, the measurement container/reaction container such as a reaction cuvette, the measurement container/reaction container of the first reaction line and the measurement container/reaction container of the second reaction line are mutually connected to each other. are placed in such a position that they do not interfere with the measurements, i.e., so that they can be measured alternately by a shared measuring device.

Therefore, in the present invention, the measurement vessel/reaction vessel of the first reaction line is connected to the measurement vessel/reaction vessel of the second reaction line so as not to block the measurement light of the second reaction line to the extent that measurement is impossible. The container is placed at a position corresponding to the container placement position question. Similarly, the measurement vessel/reaction vessel of the second reaction line is arranged in such a way that the measuring vessel/reaction vessel of the first reaction line does not block the measurement light of the first reaction line to the extent that measurement is impossible. placed in corresponding positions between the positions.

In the present invention, in the measuring device, optical members on the light source side and the light receiving side are provided in an optical arrangement with the first and second reaction lines in between. In this case, the optical members on the light source side and the light receiving side can be fixed at positions in an optical arrangement relationship, or can be provided movably while maintaining an optical arrangement relationship.

In the present invention, the first and second reaction lines are, for example,
Although it is preferable to form the turntable, it is not limited thereto, and can also be applied to, for example, a conventional conveyor-type discrete system.

(E) Function In the present invention, a first reaction line and a second reaction line are arranged in parallel, and the measurement vessels and reaction vessels arranged in the first reaction line are respectively used for the measurement and reaction vessels arranged in the second reaction line. The optical member on the light source side of the measuring device and this Since the optical members on the light receiving side corresponding to the above are provided in an optical arrangement, the first reaction line and the second reaction line can be used as analysis lines at the same time, or one can be used as an analysis line and the other can be used for cleaning. The first reaction line and the second reaction line can be used to analyze specific analysis items that differ from each other, and can be used in a variety of ways. As a chemical analyzer, it can handle many types of analysis.

For example, in the case of a turntable type, a first reaction line and a second reaction line are formed on the turntable concentrically with respect to the rotation axis, and a plurality of reaction containers such as reaction cuvettes are arranged in each reaction line. It is composed of

In this case, the turntable is rotated intermittently or continuously according to a preset time program to rotate the plurality of reaction cuvettes arranged in the first reaction line and the plurality of reaction cuvettes arranged in the second reaction line. , sequentially,
For example, the sample dispensing area, reagent dispensing area, stirring area, reaction area, and washing area are transferred in this order, and when the turntable is stopped, the sample dispensing area, reagent dispensing area, stirring area, reaction area, measurement area, and Regarding the reaction cuvettes of the first and second reaction lines located in each of the washing areas, for example, in the sample dispensing area, a predetermined amount of sample is dispensed by a sample dispensing device, and in the reagent dispensing area, a predetermined amount of sample is dispensed by a reagent dispensing device. Dispense a fixed amount of reagent, and stir the sample and reagent in the stirring area.
In the reaction region, a predetermined analytical reaction is performed, and in the measurement region, the absorbance of the component to be analyzed can be measured by a rate method, an end point method, or the like.

In addition, in the case of analysis items or samples that require a relatively long time to clean the measurement vessel and reaction vessel after measurement, either one of the first or second reaction line is used for analysis, and the other line is used for analysis. can be used for cleaning.

In this case, in the line used for analysis, the measured measurement and reaction vessels are sequentially moved to the cleaning area by intermittent movement of the turntable, and the cleaning solution is injected.
It will be used for cleaning.

On the other hand, in the line used for cleaning, the cleaned measurement and reaction vessels are sequentially moved to the sample dispensing area by intermittent movement of the turntable, where the sample is dispensed and the sample is The dispensed measurement container/reaction container is sequentially sent to a reagent dispensing area, a stirring area, a reaction area, and a measurement area, where the sample is analyzed.

The automatic chemical analyzer of the present invention is used in various ways as described above, but in any of the ways, even if the processing speed is increased to increase the processing capacity, sufficient cleaning can be performed. The automatic chemical analyzer of the invention can increase throughput with high analysis accuracy.

EXAMPLE) Examples of embodiments of the present invention will be described below with reference to the accompanying drawings, but the present invention is not limited in any way by the following description and illustrations.

FIG. 1 is a second schematic partial plan view of a reagent dispensing section of an automatic chemical analyzer according to an embodiment of the present invention.
The figure shows a schematic partial plan view of a reagent dispensing section of an automatic chemical analyzer according to another embodiment of the present invention, and FIG. 3 shows an automatic chemical analysis apparatus according to still another embodiment of the present invention. FIG. 2 is an explanatory diagram schematically showing the apparatus, centering on the cleaning section.

In Figures 2 and 3, the same symbols as in Figure 1 refer to
The same or equivalent parts as in the figure are shown.

In FIG. 1, an automatic chemical analyzer 1 includes a reaction disk 2 in the center, similar to conventional automatic chemical analyzers.
In this example, a first reaction line 4 and a second reaction line 5 in which reaction cuvettes 3 are arranged are provided in two concentric annular rows around the outer periphery of the reaction disk 2. The reaction cuvettes of the first reaction line 4 and the second reaction line 5 are arranged so that they do not overlap with respect to the center of rotation of the reaction disk 2.

Furthermore, the position of the reaction cuvette is determined so that the measurement of the reaction cuvette by the measuring device is not influenced.

Along the first and second reaction lines 4 and 5, a sample dispensing section (not shown) equipped with a sample dispenser, a pick-up type reagent dispenser equipped with two reagent dispensing nozzles 6 and 7 A reagent dispensing section 9 including a pourer 8, a washing section (not shown) including a washing device, and an absorbance measuring device 10 are provided.

In this example, when the reaction disk 2 is stopped, the reaction cuvettes 3 located in the reagent dispensers iW 11 and 12 of the reaction lines 4 and 5 are placed in the reagent dispensing section so that the reagent dispensing is performed simultaneously. 9 is provided with a reagent dispenser 8 equipped with a nozzle device consisting of two nozzles. In this example, as well as in the conventional device, at the time of this stop,
At the same time as reagent dispensing, M-body dispensing, washing, measurement, etc. are performed.

In this example, the reagent dispensing section 9 is provided with two reagent mounting tables 15 and 16, each of which has a plurality of reagent containers 1S13 arranged with their openings 14 aligned. 15 and 16 are formed as movable table types that can reciprocate in the directions of arrows 17 and 18 independently of each other, and the reagent container 13 is located at the reagent dispensing positions 11 and 12.
In order to facilitate the dispensing of reagents to the reaction cuvettes 3 located in the reaction cuvettes 3, the reagent mounting tables 15 and 16 are arranged in parallel in the reciprocating direction so as to be arranged corresponding to the position of the reaction cuvettes 3. .

The reagent mounting tables 15 and 16 are guided by meshing rack portions formed at lower end portions of their sides with stepped gears, flanged gears, etc. (none of which are shown) connected to a stepping motor. It is installed so that it can reciprocate along the rail 1 m intermittently and continuously.

In this example, the two reagent mounting tables 15 and 16 correspond to the positions of the two sample dispensing nozzles, respectively, so that the two reagent dispensing nozzles 6 and 7 can simultaneously suck and collect reagents. The reagent container to be dispensed is moved to the position. This movement of the reagent mounting table is performed by a subcomputer (none of which is shown) of the reagent dispensing section 9 that operates in response to instructions from a main computer (not shown) for analysis control.

In this way, in this example, two reagent containers are treated as a unit handled in one dispensing operation, so for example, the same analysis can be performed in both the first reaction line 4 and the second reaction line 5. When analyzing items, each reagent mounting table 15
The reagent containers can be arranged so that the reagents and 16 reagents are arranged in the same arrangement. Differently from this, for example, when different analysis items are to be analyzed in the first reaction line 4 and the second reaction line 5, the reagent arrangements on the two reagent mounting tables 15 and 16 are different from each other. In this example, cleaning tanks 19 and 20 for cleaning the reagent dispensing nozzles are provided between the reagent mounting tables 15 and 16 and the reaction disk 2. There is.

In this example, the reagent is dispensed by the reagent dispenser 8 by sucking the reagent into the reagent dispensing nozzles 6 and 7 at the reagent suction and collection positions 21 and 22 of the reagent mounting tables 15 and 16, and then dispensing the reagent into the reaction lines 4 and 7. In order to dispense the aspirated reagent to the reaction cuvettes 3 located at the reagent dispensing positions 11 and J2 of 5, the reagents are placed at the reagent a suction and collection positions 21 and 22 of the reagent a placement stands 15 and 16 and the reagents of the reaction lines 4 and 5. Dispensing position 11 and 1
2 in the direction of arrow 23, and
In order to wash and clean the reagent dispensing nozzle after reagent dispensing, the cleaning positions 24 and 25 of the reagent dispensing nozzles 6 and 7 in the cleaning tanks 19 and 20 and the reagent suction collection position 21
and 22, reagent dispensing positions 11 and 12, and washing section
1. It is formed to be movable in the direction of arrow 23 between 24 and 25.

In this example, similarly to conventionally known automatic chemical analyzers, an absorbance measuring device for analysis item components, which includes a light source section 26 and a measuring section 27, is movably provided. A constant temperature bath (not shown) is provided with a side wall having a window, and is configured to be able to adjust the reaction temperature and measure absorbance.

Since this example is configured as described above, first, the subcomputer of the reagent dispensing section 9 is operated to move the reagent mounting tables 15 and 16, and the reagents on the reagent mounting tables 15 and 16 are dispensed. The reagent containers 13 are moved to the reagent suction collection position 21.
and 22, the two reagent dispensing nozzles 6 and 7 are lowered from the upper position at the positions 21 and 22, and inserted into the openings 14 of the two reagent containers 13, respectively. The reagents in the reagent containers 13 are sucked and collected into the two reagent dispensing nozzles 6 and 7. Next, when the reagents have been sucked into the two reagent dispensing nozzles, the two reagent dispensing nozzles are sucked into the two reagent dispensing nozzles. After the nozzles 6 and 7 are raised to the upper position, the reagent mounting tables 15 and 16 are moved by arrows 17 and 18 so that the reagent container 13 into which the next reagent is dispensed is positioned at the reagent suction collection positions 21 and 22. be moved in the direction of

The two reagent dispensing nozzles 6 and 7 that have sucked the reagent are moved above the reagent dispensing positions 11 and 12, respectively, and stopped;
Move the reagent dispensing position 1 downward from the upper position.
1 and 12, the reaction stops and the collected reagents are discharged into the two reaction cuvettes 3 located at the reagent dispensing positions 11 and 12 of the reaction lines 4 and 5. Once the reagent has been discharged, move the two reagent dispensing nozzles 6 and 7 up to the upper position from the reagent dispensing position, then turn the arrow 23
direction to the respective cleaning positions 24 and 25.

When the two reagent dispensing nozzles are located at the cleaning positions 24 and 25, the two reagent dispensing nozzles 0 and 7 are lowered, and the reagent dispensing nozzles 6 and 7 are placed in the cleaning tanks 19 and 20.
The respective reagent dispensing nozzles 6 and 7 are immersed in the cleaning solution in the
Clean the area.

During this time, the reaction lines 4 and 5 are moved by a predetermined pitch in the direction of arrow 28 so that the reaction cuvette 3 into which the next reagent is dispensed is placed at the reagent dispensing position (i). The intermittent movement of 5 is carried out periodically, and by this intermittent movement, the reaction cuvette 3 into which the reagents have been dispensed is moved along the respective reaction lines 4 and 5 to the next reagent dispensing position or washing position. ), during which the absorbance measuring device t 10 is moved to separate the reaction cuvettes 3 located in the measurement area 29 of the reaction line 4 and the reaction cuvettes 3 located in the measurement area 29 of the reaction line 5. The absorbance is measured alternately.

In the embodiment shown in FIG. 2, the analysis items measured in reaction line 4 and the analysis items analyzed in reaction lines are determined to be different.9 Therefore, reaction line 4 and reaction line 5 are In this case, even if the sample dispensed by the sample dispenser is the same, the analysis items are different, so the reagent dispensed by the reagent dispenser is different.

In this example, as in the embodiment shown in FIG.
Sample aliquot 7g with 031. A reagent dispensing section 9 equipped with a reagent dispenser 32, a stirring section equipped with a stirring device, a reaction section equipped with a constant temperature device, a cleaning section equipped with a washing and dehydrating device (all not shown for convenience of explanation), and a light source section 26. and a measuring head tIi29 in which the absorbance measuring device M and 10 are movably provided.

In this example, for convenience of explanation, the number of analysis items is set to be relatively small, and the number of reagent dispensers 32 disposed in the reagent dispensing section 9 is four.

In this example, the sample dispensing section 31 of the reaction disk 2 includes:
A sampling table 34 for dispensing a sample, in which a plurality of sample cups 33 are arranged in a circular row, and a sample dispenser 30 are provided adjacent to the sampling table 34 .

In the sample dispensing section 31, the nozzle section 35 of the sample dispensing device 30 is connected between the sample aspiration collection position 37 and the sample dispensing position 38 of the reaction line 4 and the sample aspiration position along the dashed line 36 in FIG. Collection position 37 and sample dispensing position 39 of reaction line 5
or by moving it from the sample aspiration collection position 37 to the sample dispensing position 38 of the reaction line 4 and further to the sample dispensing position 39 of the reaction line 5, so that it is located in each of the reaction lines 4 and 5. The sample can be dispensed into the reaction cuvette 3, or the operation of one sample dispensing can be stopped,
It is also possible to pipet the sample into only one reaction line.

The nozzle section 35 of the sample dispenser 30 is cleaned with a cleaning liquid in a cleaning pot every time a sample is dispensed, but in this example, a conventional device is sufficient for the sample dispensing section 31, including the cleaning pot. Washing pots 1 and 4 are not shown.

In this example, a reagent dispensing section 9 including a reagent dispensing device 32 is provided downstream of the intermittent rotation direction 40 (arrow) of the reaction disk 2 with respect to the specimen dispensing device 30 .

The reagent dispensing unit 9 is equipped with two reagent dispensers 43 and 44 for dispensing reagents into the reaction cuvettes 3 located at reagent dispensing positions 41 and 42 of the reaction line 4.
Furthermore, two reagent dispensers 47 and 48 are provided for dispensing reagents into the reaction cuvettes 3 located at reagent dispensing positions 45 and 46 of the reaction line 5.

In this example, these reagent dispensers 43, 44, 47
The dispensing reagents assigned to and 48 are different from each other.

These reagent dispensers 43, 44, 47 and 48 are each equipped with one reagent dispensing nozzle, and the reagent dispensing nozzles 49 and 50 of the reagent dispensers 43 and 44 are connected to the reaction line 4.
Dispensing nozzle ends 51 and 52 are fixedly provided above the reagent dispensing positions 41 and 42 so that the reagent can be dispensed into the reaction cuvettes 3 located at the reagent dispensing positions 41 and 42, and The reagent dispensing nozzles 53 and 54 of the reagent dispensers 47 and 48 are configured to dispense into the reaction cuvettes 3 located at the reagent dispensing positions 45 and 46 of the reaction line 5.
Dispensing nozzle ends 55 and 56 are fixedly provided above the reagent dispensing positions 45 and 46, respectively.

Since each reagent dispenser 43, 44, 47 and 48 has the same structure, the structure will be explained using the reagent dispenser 47 as an example.

The reagent dispenser 47 is provided with a flow path switching valve 57, and the reagent dispensing nozzle 53 is connected to the first flow path 5 of the flow path switching valve 57.
8, and a second flow path 59 of the flow path switching valve 57 is connected to a plunger pump 60. The tip of the third flow path 61 of the flow path switching valve 57 is immersed in the reagent in the reagent container 62, and the suction operation of the plunger pump 60 causes water to flow from the reagent container 62 through the third flow path 61. A predetermined amount of reagent can be drawn into the plunger pump 60 by suction.

Therefore, when dispensing a reagent using the reagent dispenser 47, the subcomputer (not shown) of the reagent dispensing unit 9 is used before stopping the reaction disk 2.

), the piston 63 of the plunger pump 60
1. When the reaction disk 2 has stopped, the piston 63 of the plunger pump 60 is moved to the discharge side, and a predetermined amount of the reagent in the reagent container 62 is sucked into the plunger pump 60. A predetermined amount of the dispensing reagent collected in the plunger pump 60 is transferred to the reagent dispensing position 4.
Dispense and dispense into the reaction cuvette 3 located at 5.

In this way, the reagent dispensing position 51 of reaction lines 4 and 5
．． Reagents are dispensed into reaction cuvettes 3 located at 52, 55 and 56. After the reagents are dispensed in this way, the reaction cuvette 3 is moved in the moving direction 4 by the movement of the reaction disk 2.
0 and measured by an absorbance measuring device.

Therefore, according to this example, since the reaction cuvettes 3 of other reaction lines are arranged between the reaction cuvettes 3 of the reaction line 4 for measurement, the area around the reaction disk 2 can be used for measurement without wasting it. Therefore, the analytical processing capacity can be significantly increased compared to an automatic chemical analyzer using a reaction disk 2 of the same size.

Moreover, in the case of this example, the sample and reagent can be simultaneously dispensed into the reaction cubera l- of reaction lines 4 and 5.
Comparing the sample dispensing time and reagent dispensing time with the conventional example with the same number of reaction cuvettes, this example shows that the time required for these dispensing is significantly shortened compared to the conventional example. In these embodiments, although the optical systems are different between reaction line 4 and reaction line 5, analysis accuracy can be improved by performing calibration for each reaction line.

This example can be similarly configured for automatic chemical analyzers of multi-reagent systems, such as two-reagent systems, three-reagent systems, as well as one-reagent systems.

Further, in this example, for example, only the reagent dispensers 43 and 44 for reaction line 4 are operated for reagent dispensing, and the reagent dispensers 47 and 48 for reaction line 5 are operated for reagent dispensing. It can be stopped and the reaction line 4 used for analysis and the reaction line 5 used for washing the reaction cuvette 3.

In this case, the cleaning section 64 of the reaction lines 4 and 5 can be formed using two conventional cleaning devices.

In the embodiment shown in FIG. 3, the cleaning device includes a discharge section 67 having suction nozzles 65 and 66 for discharging the contents of the reaction cuvette 3, a cleaning water injection nozzle 68, and a suction nozzle 69 for discharging cleaning waste water, respectively. It is provided with a first cleaning section 70, a second cleaning section 71, and a third cleaning section 74 including a detergent injection nozzle 72 and a discharge suction nozzle 73.

The suction nozzles 65 and 66 suction the contents from the reaction cuvettes 3 located at the discharge portions W75 and 76 of the reaction lines 4 and 5.

The first washing section 70 is the second washing section 1 for the reaction lines 4 and 5.
In reaction cuvette 3 located in tffi77 and 78,
Cleaning water is injected through a cleaning water discharge nozzle 68, and its waste water is discharged through six suction nozzles.

Similar to the first washing section 70, the second washing section 71 injects washing water into the reaction cuvettes 3 located at the second washing positions 79 and 80 of the reaction lines 4 and 5 through the washing water discharge nozzle 68. When the reaction line 4 moves to the measurement side, the next suction nozzle 69 discharges waste water not to the reaction cuvette 3 of the reaction line 4, but only to the reaction cuvette 3 of the reaction line 5. The positions following the third washing positions t 79 and 80 of 4 and 5 are the cuvette blank measurement positions 81 and 82, and in this example, the target is the reaction cuvette 3 of the reaction line 4 that moves to the measurement side. The cuvette blank is then measured.

Cuvette blank measurement position W, 8 for reaction lines 4 and 5
Adjacent positions 83 and 8.4 downstream of 1 and 82 are third cleaning positions.

In this third washing position, the reaction cuvette 3 located at the third washing position 83 of the reaction line 4 transitioning to the measurement side
Water for cuvette blank measurement is discharged by the discharge suction nozzle 73, dehydrated, and sent to the sample dispensing position.

On the other hand, in the reaction line 5 that moves to the washing side, the reaction cuvette 3 located at the third washing position 84 is injected with detergent by the detergent injection nozzle 72, and the arrow 8
It is sent in the direction 5 for cleaning.

In this example, since the washing section is configured as described above, the reaction line 4 moving to the analysis side is as follows.

Stage (■): Discharge of the detergent from the washed reaction cuvette 3 located at the discharge position 75 after the cleaning time has elapsed by the suction nozzle 65. Stage (■) located at the first washing position 77: Stage (2) : Step ■: Step ■: Injecting the cleaning water into the reaction cuvette 3 by the cleaning water injection nozzle 68 and discharging the cleaning wastewater by the suction nozzle 69 for discharging the cleaning wastewater after injection, and discharging the cleaning wastewater to the second cleaning position 79. Injection of wash water by the wash water injection nozzle 68 into the reaction cuvette 3 located at the cuvette blank measurement position 81, measurement of the cuvette blank for the reaction cuvette 3 located at the cuvette blank measurement position 81, and injection of wash water from the reaction cuvette 3 located at the third washing position 83. The discharge suction nozzle 73 discharges the washing water for measuring the cuvette blank.On the other hand, in the reaction line 5 that moves to the washing side, it corresponds to the steps from ■ to ■ in the reaction line 4. Step ■: Stage ■: Stage ■: Stage ■: Stage N: Discharge of the reaction liquid from the measured reaction cuvette 3 using the suction nozzle 66 for discharging the contents, 1st - Washing section! Injection of washing water by a washing water injection nozzle 68 into the reaction cuvette 3 located at 78 and discharge of washing water by a suction nozzle 69 for discharging washing wastewater after injection, located at a second washing position 80. Injection of washing water into the reaction cuvette 3 using the washing water injection nozzle 68, discharging washing wastewater using the suction nozzle 69 for discharging washing wastewater after injection, injection of washing water, discharging the washing water, cuvette blank measurement position. At 82, the device is empty, and detergent is injected by the detergent injection nozzle 72.

As described above, the cleaning section in this example can easily accommodate various usage modes by providing a total of four pick-up type nozzles along each of the reaction lines 4 and 5.

(g) Effects of the invention In the present invention, a first reaction line and a second reaction line are arranged in parallel, and the measurement vessels/reaction vessels arranged in the first reaction line are arranged in the second reaction line, respectively. The first reaction line is arranged at a position corresponding to the first reaction line between the arrangement positions of the measurement vessels/reaction vessels to form measurement vessel/reaction vessel rows of the first reaction line and the second reaction line, respectively, and the first reaction line Since the optical member on the light source side of the measurement device and the corresponding optical member on the light receiving side are arranged in an optical arrangement across the second reaction line, compared to conventional automatic chemical analyzers,
The spacing between the array of measurement containers and reaction containers in the reaction line can be used without waste for optical measurements, and the analytical throughput can be increased accordingly.

In the present invention, the measurement work of two reaction lines can be performed simultaneously using, for example, one measuring device, so the throughput of the measuring device can be increased compared to conventional automatic chemical analyzers. Even if the number of measurement containers/reaction containers is increased, analysis errors between measurement devices can be avoided, so analysis accuracy can be improved compared to conventional automatic chemical analyzers.

In the present invention, two reaction lines are provided at equal pitches, so one reaction line can be used for analysis and the other for cleaning without waste, which was difficult with conventional automatic chemical analyzers. Both reaction lines can be easily used alternately for the analysis step and the washing step, and the washing can take a long time, allowing accurate analysis.

Furthermore, according to the present invention, liquid containers can be easily arranged according to analysis items, the time required for liquid dispensing can be significantly shortened, and analysis can be performed efficiently. Therefore, according to the present invention, compared to conventional automatic chemical analyzers,
The measurement container and reaction container can be used without waste.
Analytical processing can be significantly improved.

[Brief explanation of the drawing]

FIG. 1 shows the reagent dispensing section of an automatic chemical analyzer according to an embodiment of the present invention. A partial plan view of M is shown. FIG. 2 shows a schematic partial plan view of a reagent dispensing section of an automatic chemical analyzer according to another embodiment of the present invention. FIG. 3 is an explanatory diagram showing an outline of an automatic chemical analyzer according to still another embodiment of the present invention, centering on the cleaning section. Regarding the symbols in the figure, 1 is an automatic chemical analyzer, 2 is a reaction disk, 3 is a reaction cuvette, 4 is a first reaction line, 5 is a second reaction line, 6 and 7 are two reagent dispensing units. Nozzle, 8 is a pick-up type reagent dispenser, 9 is a reagent dispensing section, 10 is an absorbance measuring device, 11 and 12 are reagent dispensing positions, 13 is a reagent container, 14 is an opening of the reagent container, 15
and 16 are reagent mounting tables; ] 7 and 18 are arrows indicating the moving direction; 19 and 20 are cleaning tanks for cleaning the reagent dispensing nozzle;
21 and 22 are reagent suction and collection positions, 23 is an arrow indicating the direction of movement, 24 and 25 are cleaning positions, 26 is a light source section, 27
28 is a measuring section, 28 is an arrow indicating the direction of movement, 29 is a measurement area, 30 is a sample dispenser, 31 is a sample dispenser, 32 is a reagent dispenser, 33 is a sample cup, and 34 is a sample dispenser. A sampling table, 35 is a nozzle part, 36 is a chain line indicating a route, 37 is a sample suction collection position, 38 is a sample dispensing position,
39 is the sample dispensing position, 40 is the intermittent rotation direction (arrow),
41 and 42 are reagent dispensing positions of reaction line 4, 43.4
4.47 and 48 are reagent dispensers, 45 and 46 are reagent dispensing positions of reaction line 5, 49 and 50 are reagent dispensing nozzles, 51.52.55 and 56 are dispensing nozzle ends, 53 and 54 are Reagent dispensing nozzle, 57 is a flow path switching valve, 58 is a first flow path, 59 is a second flow path, 60 is a plunger pump, 61 is a third flow path, 62 is a reagent container, 63 is a piston , 64 is a cleaning section, 65 and 66 are suction nozzles for discharging contents, 67 is a discharge section, 68 is a cleaning water injection nozzle, 69 is a suction nozzle for discharging cleaning waste water, 70 is a first cleaning section, 71
72 is a detergent injection nozzle, 73 is a suction nozzle for discharge, 74 is a third cleaning section, 75 and 76 are discharge positions, 77 and 78 are first cleaning positions, and 79 and 80 are second cleaning positions. Washing positions 81 and 82 are cuvette blank measurement positions 583 and 84 are third washing positions, and 85 is an arrow indicating the direction of movement. agent

Claims (1)

[Claims] In an automatic chemical analyzer, a reaction line is formed by arranging a plurality of reaction vessels, and a sample dispensing device, a reagent dispensing device, a measuring device, and a cleaning device are provided around the reaction line. The first reaction line and the second reaction line are arranged in parallel, and the measurement vessels/reaction vessels arranged in the first reaction line are located between the arrangement positions of the measurement vessels/reaction vessels arranged in the second reaction line, respectively. The light source side member and the corresponding light receiving side member of the measuring device are arranged in an optical arrangement with the first reaction line and the second reaction line in between. An automatic chemical analyzer characterized by: