JPH02145508A - Dandruff-preventing cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic which has dandruff-preventing effect equal to or more excellent than pyrithione zinc with improved safety to skin by using asparagusic acid and/or its derivative. CONSTITUTION:At least one selected from asparagusic acid and its derivatives of formulas I to III (R is H, alkyl, K, Na) is added, as an essential component, to a known cosmetic base for hair in an amount of 0.001 to 1wt.% based on the total cosmetic to give the subject cosmetic which has dandruff-preventing effect equal to or more excellent than pyrithione zinc which has excellent dandruff-preventing effect and excellent safety. The pyrithione zinc has a problem in safety.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention provides an anti-dandruff makeup characterized by containing one or more selected from the group consisting of asparagus acid and asparagus acid derivatives. Regarding fees.

[Prior art] Generally, dandruff consists of secretions from sebaceous glands, secretions from sweat glands, and detached substances from the epidermal layer, etc., and is usually caused by increased secretion of sebaceous glands, etc., but when the skin is infected with bacteria or yeast, dandruff The outbreak is said to be facilitated pathologically. For this reason, hair cosmetics containing antibacterial agents have traditionally been used to prevent dandruff. For example, zinc pyrithione has been used as the most effective anti-dandruff drug, but it is well known that this substance also falls under the category of antibacterial agents.

However, some of these antibacterial agents have safety problems, and it is considered preferable to avoid using them in large quantities.

[Problems to be Solved by the Invention] In view of the above circumstances, the present inventors have conducted extensive research in order to obtain an anti-dandruff substance that is satisfactory in terms of skin safety and is comparable in effectiveness to zinc pyrithione. As a result of repeated research, it was discovered that asparagus acid and asparagus acid derivatives are extremely useful for preventing dandruff, and safety can also be improved, leading to the completion of the present invention.

[Means for Solving the Problems] That is, the present invention provides an anti-dandruff cosmetic containing one or more selected from the group consisting of asparagus acid and asparagus acid derivatives. It is something to do.

When the anti-dandruff cosmetic of the present invention is used, the metabolic reaction within the scalp tissue is moderately adjusted, and it is thought that the occurrence of dandruff can be significantly prevented, but the effect is almost equal to or superior to that of zinc pyrithione. It was recognized that there was.

Hereinafter, the configuration of the present invention will be explained in detail.

Asparagus acid and asparagus acid derivatives used in the present invention are compounds having the following structural formula.

(R represents hydrogen, an alkyl group, potassium, or sodium) For example, the compound represented by the general formula (1) includes asparagus acid, potassium salt, sodium salt of asparagus acid,
Methyl ester, ethyl ester, dodecyl ester,
Examples include esters such as oleyl ester, stearyl ester, palmityl ester, palmitooleyl ester, benzyl ester, and cinnamyl ester. Compounds represented by general formula (2) include dihydroasparagasic acid, potassium salt, sodium salt, methyl ester, ethyl ester, dodecyl ester, oleyl ester, stearyl ester, valmityl ester, and palmitooleyl of dihydroasparagasic acid. Esters, benzyl esters, cinnoxides are 5ynthesis 60
7. (1973), it is also possible to synthesize it from bishydroxymethylmalonate, and esters can also be obtained by condensing the corresponding carboxylic acid with an alcohol.

The anti-dandruff cosmetic of the present invention can be prepared by blending one or more selected from the group consisting of asparagus acid and asparagus acid derivatives obtained as described above into a known hair cosmetic base. get.

The anti-dandruff cosmetics of the present invention broadly refer to those used for the scalp or hair, such as hair tonics, hair liquids, scalp emulsions, hair creams, hair shampoos, hair rinses, hair sprays, etc. is included.

The blending amount is 0.001 to 10% by weight based on the total amount of the anti-dandruff cosmetic. If it is less than 0.001% by weight, the anti-dandruff effect tends to be poor, and if it exceeds 10% by weight, no substantial increase in the effect can be expected.

In addition to the above-mentioned essential ingredients, the anti-dandruff cosmetic of the present invention contains ordinary ingredients that can be incorporated into cosmetics, pharmaceuticals, etc., such as aqueous ingredients, powder ingredients, antioxidants, alcohol, oil, ultraviolet absorbers, surfactants, Preservatives, humectants such as hyaluronic acid, fragrances, water, alcohol, thickeners, coloring agents, fragrances, drugs, and the like can be added as appropriate.

[Example] Next, the present invention will be explained in detail with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.

Based on the formulation in Table 1, a hair tonic is produced by adding asparagasic acid and/or asparagasic acid derivatives to purified water, and then sequentially adding ethanol, polyoxyethylene (8) oleyl ether, coloring matter, and fragrance. The anti-dandruff effects of these products were then measured.

The test was conducted on 24 men between the ages of 20 and 55 who had a relatively large amount of dandruff.

Before the start of the test, the subjects' hair was washed with a chemical-free shampoo, and the hair was styled with a chemical-free hair tonic.The dandruff accumulated in the two days after washing was collected twice a week for one month, and the collected dandruff was collected. The protein amount was measured (control period). The panel was then divided into 8 groups of 3 people each and asked to use a drug-containing hair tonic and a drug-free shampoo for one month. As in the control period, accumulated dandruff was collected twice a week for 2 days after hair washing, and the protein amount was measured (sample period).Hair tonic was used once daily, and the average dandruff protein amount in the control period was measured. Compare the amount of dandruff protein with the average dandruff protein amount during the sample period, and if the dandruff reduction rate is 50% or more, A1. If the dandruff reduction rate is 40 to 50%, B1.
The case of 0% to 40% was ranked as 01, and the case of lower than that was ranked as D.

The results are shown in Table 1.

As a result, it was found that asparagus acid and asparagus acid derivatives significantly prevented dandruff.

Example 6 79.9 g of purified water, 15 g of lauryl sulfate triethanolamine, 5 g of coconut oil fatty acid monoethanolamide,
0.01 g of potassium asparagus acid salt, 0.01 g of potassium dihydroaspartate salt, and appropriate amounts of pigments and fragrances were added, heated and mixed, and then cooled to obtain a hair shampoo having an anti-dandruff effect.

Example 7 52.5 g of ethyl alcohol, 20 g of polyoxypropylene butyl ether, 0 aspartic acid ethyl ester
．． A hair liquid having an anti-dandruff effect was obtained by mixing an alcohol phase containing 2 g of squalane and an appropriate amount of fragrance dissolved at room temperature with an aqueous phase containing 27.3 g of purified water and an appropriate amount of a pigment.

Example 8 To 55 g of ethyl alcohol, 2 g' of polyoxyethylene (8 mol) oleyl alcohol ether and appropriate amounts of fragrance were added and dissolved at room temperature to obtain an alcohol phase. Separately, 5 g of glycerin and 5 g of asparagus acid were added to 28 g of purified water and dissolved by heating. After cooling, an appropriate amount of dye was added, and an alcohol phase was added to the aqueous phase to solubilize it to obtain a hair tonic with anti-dandruff effect.

Example 9 2g stearic acid, 7g stearyl alcohol.

2 g of lanolin, 5 g of squalane, 6 g of octyldodecanol, 3 g of polyoxyethylene (10 mol), cetyl ether, 2 g of glyceryl monostearate.

A suitable amount of fragrance was added and heated to 80°C to obtain an oil phase. Separately, 5 g of propylene glycol, 0.1 g of asparagus acid oxide, and 38 g of purified water were gradually added to the water phase heated to 80°C while stirring the oil phase, emulsified, and cooled to create a hair cream with anti-dandruff effect. I got it.

Example 10 3.5 g of polyethylene glycol 1500, triethanolamine Ig, and 0.01 g of dihydroasparagus acid
was heated and dissolved in 74.4 g of purified water and kept at 70°C.

2.5 g of stearic acid, 1.5 g of cetyl alcohol, 5.0 g of petrolatum, 10.0 g of squalane, and 2.0 g of polyoxyethylene (10 mol) monooleic acid ester.
g was dissolved by heating and added to the aqueous phase while keeping the volume at 7 liters.After the initial emulsification, it was uniformly emulsified with a homomixer and slowly cooled to prepare an M waste emulsion with an anti-dandruff effect.

Example 11 2g stearic acid 1.5g cetyl alcohol, 3g vaseline, 12g liquid paraffin 1 polyoxyethylene (
10 mol) monooleic acid ester 2g.

0.005 dihydroaspartic acid oleyl ester
g and an appropriate amount of fragrance were mixed and heated to 80°C to obtain an oil phase.

Separately, heat 5g of propylene glycol, 1g of triethanolamine, and 72.1g of purified water to 80°C, gradually add the above oil phase to the water phase while stirring, emulsify, and then cool to prevent dandruff. A milky lotion was obtained.

Claims (1)

[Claims] (1) Dandruff characterized by containing one or more selected from the group consisting of asparagus acid and asparagus acid derivatives represented by the following general formulas (1), (2) and (3). Prevention cosmetics. ▲There are mathematical formulas, chemical formulas, tables, etc.▼(1) ▲There are mathematical formulas, chemical formulas, tables, etc.▼(2) ▲There are mathematical formulas, chemical formulas, tables, etc.▼(3) (R is hydrogen, alkyl group, potassium, sodium )