JPH02138129A - Lubricant - Google Patents

Abstract

PURPOSE:To obtain a lubricant, consisting essentially of a root extract of a plant Abelmoschus manihot Medicus, excellent in lubricity and feeling of use and suitable for sexual life of the aged, making a diagnose of obstetrics and gynecology, urology, etc., and protecting mucous membranes. CONSTITUTION:A root of a fresh dried Abelmoschus manihot Medicus is dipped in an aqueous solution of ethanol overnight and shredded. An aqueous solution of methanol is then added thereto and the obtained mixture is stirred and sterilized to remove pigments, such as chlorophyll. After drying, water in an amount of 20-40 times is subsequently added and the resultant mixture is stirred and extracted. Ethanol is then added to the obtained extract solution to deposit precipitates, which are separated, sufficiently washed with ethanol and dried to afford a mucilaginous substance consisting essentially of saccharides, such as rhamnose, galacturonic acid or glucuronic acid. A gelling agent, pH adjustor, lubrication adjuvant, etc., as necessary, are added to the afore-mentioned mucilaginous substance to afford the objective lubricant.

Description

[Detailed description of the invention] (Industrial application field) The present invention relates to a novel lubricant.

(Prior art) AbelIO, a plant belonging to the mallow family,
oscbus manihot Medicus
or II 1biscus 1IIaniboL
The root of L. , ) contains 15% mucilage, and this mucilage has been used in the production of Japanese paper to evenly distribute the fibers. The cooling agent has also been used medicinally as a substitute for Althea (Altl+aeao [1cinalis)], an agent for intestinal catarrh, an antitussive, and the like.

) Many studies have been conducted on the mucilage substance of the root of Loro mallow, such as CI+e ring.

Pbaria, Bull, 25 3081 (19
77), Cbcv+, Pharm.

Bull, 271651 (+979) obtains polysaccharides by a similar method. Particularly recently, a report has been disclosed in JP-A-57-98212 in which an acidic polysaccharide having a molecular weight of 25,300 and having anticancer activity was isolated.

In addition, in recent years, the reality of sexual life among middle-aged and elderly people has been that due to the decline in women's secretory function, the decrease or depletion of the V5 fluid has led to a decline in tissue resistance to external stimulation, trauma, and infection, and a decline in self-purification. As a result of this, sexual activity cannot be performed smoothly and is painful, and the patient is easily injured and infected with bacteria. In the past, soft flints and the like were used as substitutes, but these were unhygienic and left a feeling of stiffness, stickiness, and discomfort.

On the other hand, in actual medical practice in obstetrics and gynecology, urology, etc., when a medical examination instrument is inserted into the affected area for examination - 2. Easier insertion 1. In order to rub the examination instrument, conventionally, glycerin, quinlocaine, etc. are applied to the examination instrument. However, all of these lubricants were irritating or anesthetic and were not necessarily desirable, so there is an increasing demand for lubricants for insertion in this medical field. is the current situation.

(Problems to be Solved by the Invention) In view of the above-mentioned circumstances, the purpose of the present invention is to provide a product suitable for the sexual life of middle-aged and elderly people, for medical treatment in obstetrics and gynecology, urology, etc., and for protecting mucous membranes. The objective is to provide a lubricant that is

(Another Means to Solve the Problems) The present invention relates to a lubricant containing as a main component the root extrudate of the plant A. japonica.

The root extract of A. japonica, which is the main component of the lubricant of the present invention, can be obtained using the root of A. japonica as a raw material, for example, in the following manner.

Fresh dried roots of A. japonica are immersed in an ethanol aqueous solution overnight, then cut into pieces, a methanol aqueous solution is added and stirred to sterilize the plant and remove pigments such as chlorophyll. Add approximately 20 to 40 times the amount of water to the dried product and stir to extract. At this time, it is desirable to perform the water temperature at a temperature of about 30° C. or lower; if the extraction is carried out at a high temperature, many impurities will be eluted, making it impossible to obtain a high-quality A. japonica extract. Also, the amount of water is
If it is carried out at 20 times or less, it will result in a highly viscous solution, making it difficult to separate the residue and mucus, making the extraction process complicated, and affecting quality. After removing the extraction residue, it is filtered and purified using oven cloth, filter paper, cellulose powder, etc.

Ethanol is added to the obtained extract to precipitate. The separated precipitate is thoroughly washed with the specified solvent and dried to obtain a mucilaginous substance (light brown to pale yellow).

When producing the above-mentioned precipitate, methanol, propatool, butyl, acetone, etc. do not produce good precipitates and are difficult to treat, whereas ethanol provides the cleanest precipitate and the greatest amount of precipitate. However, if a large amount of water is used during extraction, Suikokis precipitates when an organic solvent is added to the extract, but a large amount of organic solvent is required. Therefore, it is preferable to concentrate the extract as a pretreatment for the precipitation operation. At this time, it was 111! To shorten the time, if the process is carried out under reduced pressure at 40°C or lower, no deterioration in quality will be observed.

The main components of the extract are mainly saccharides such as rhamnose, galacturonic acid, and glucuronic acid, and it also contains about 1% protein.

The lubricant of the present invention may optionally include, for example, a deltizing agent such as carboxyvinyl polymer, a pH1 adjuster, a lubricating aid, etc.
Furthermore, fragrances can be added.

In addition, since bacteria are likely to contaminate and grow in jelly, preservatives, preservatives, etc. may be added as necessary. 4. As the conditioner, for example, sodium hydroxide or aqueous ammonia, as the lubricating aid, for example, polyethylene glycol, polyvinyl alcohol, carboxymethyl cellulose, sodium alginate, polyacrylic acid, etc., as the preservative, for example, paraoxygen. Benzoic acid esters (methyl, ethyl,
propyl, butyl ester), etc.

The lubricant produced here can be applied to the vulva of women during sexual activities for middle-aged and older people, for example, or applied around contraceptive devices such as condoms for use in sexual life, and can be used in obstetrics and gynecology, urinary tract, etc. Used for medical treatment, hemorrhoid surgery, as a body lotion for people with dry skin, and for protection against mucous membranes used when wearing contact lenses. be able to.

(Example) The present invention will be specifically explained below by giving examples.

Example 1 (Production method of ethanol precipitate extract) φ2 dried molasses [1kl? was immersed in 70v/v% ethanol 51 overnight, and this was cut into pieces and stirred twice for 12 hours using 50v/v% methanol 101. Next, this was extracted with 5ON of water and stirred for 6 hours. The extract 48t' obtained here is a clear yellow-brown aqueous solution, which is concentrated under reduced pressure at below 40°C to approximately 21%.
This was added to ethanol 251 with stirring to obtain an ethanol precipitated fraction of the water extract of A. japonica species.

Example 2 (Aqueous lubricating jelly formulation example 1) Formulation example I
V/V% Tororo mallow extract
0.3-0.5 carboxyvinylpo+77-
0.5 Sodium chloride 0.51 Methyl p-oxybenzoate 0.025 Propyl p-oxybenzoate 0.0751N-Sodium hydroxide Appropriate amount Flavor Appropriate amount Purified water Appropriate amount Total amount 100 Heat 90 ml of pseudo-purified water to about 80°C and add paraoxybenzoic acid. After dissolving methyl and propyl barooxybenzoate, sodium chloride and the tar precipitated powder extract of A. japonica are sequentially dissolved and stirred at room temperature, and then the carboxyvinyl polymer is dispersed therein.

Then v to pH 7 using IN-sodium hydroxide.
4. After adding purified water to make up to 100ml, add fragrance and autoclave for +00'Cl2O minutes. Or filtered with a 0.22 μm filter.

Example 3 (Production method of A. japonica extract) Dry A. japonica roots 1 and 8 were immersed in 70 v/v% ethanol 5I overnight, and this was chopped into 50 v/v% methanol IO.
The mixture was stirred with N twice for 12 hours. Next, water 501 was added to this, and the mixture was stirred for 6 hours for extraction. The extract 481 obtained here was used in Formulation Example 2 and below.

Example 4 (Aqueous lubricating jelly treatment) Example 1 2) Formulation example 2
Deception/V% Tororo mallow extract
0.3-0.5 carboxyvinyl polymer
0.1 polyethylene glycol 10.01N
- Sodium hydroxide Appropriate amount Flavor Appropriate amount Purified water Appropriate amount Total amount 1001 Ill lfj Water 10ml l 1. : E') Sequentially dissolve and stir ethylene glycol and A. japonica extract.
Then, the hecarpo-divinyl polymer is dispersed therein.

Then using IN-sodium hydroxide 1. l1t3
, 3, and added purified water to make 100ml.
Fragrance was added and autoclaved at 100°C for 20 minutes.

Alternatively, it was filtered using a 0.22 μm filter.

Example 5 (Aqueous lubricating jelly formulation example 3) Formulation example 3 w/v
% Yellow mallow extract 0.3-0.5 Carboxyvinyl polymer 0.2 Polyethylene glycol 5.01N-Sodium hydroxide Appropriate amount Flavor Appropriate amount Purified water Appropriate amount Total amount 100- Produced in the same manner as in Formulation Example 2.

Example 6 (Water-based lubricating jelly formulation example 4) Formulation example 4
w/v% Troro mallow extract
0.3-0.5 fragrance
Appropriate amount of purified water Appropriate amount of total ffi 100ml Produced in the same manner as Prescription Example 2.

Furthermore, a preservative can be added to Formulation Examples 2 to 4 in the same manner as in Formulation Example].

Test Example 1 An effectiveness test of the above lubricant was conducted on middle-aged and elderly women. The water-based lubricating jelly of Formulation Example 1.2 was inserted or injected into the vagina of a middle-aged and elderly woman, and its feeling of use, elongation (I/J% ratio), and stinging properties were examined. The results are shown in Tables 1 and 2.

Table 1 (Prescription 1) No. table (Prescription 2) As a medical treatment, Furthermore, it has wide applicability for mucosal protection. has.

(that's all) Antibody Chemical Industry Co., Ltd.

Claims (1)

[Claims] (1) A lubricant containing as a main component an extract of the root of the plant A. japonica.