JPH013118A - L-ascorbic acid preparation - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

Detailed Description of the Invention "Field of Industrial Application" The present invention relates to a formulation of L-ascorbic acid or its salts that is stable under the conditions of use when used as an additive for foods, feeds, etc., and a method for producing the same. In particular, the present invention relates to formulations of L-ascorbic acid or its salts that are difficult to dissolve in a medium containing moisture or the like.

"Prior art" L-ascorbic acid and its salts are extremely important nutritionally, and a deficiency thereof causes anemia in humans.
Bleeding from the gums, skin, and mucous membranes causes what is called scurvy, and its deficiency is known to cause serious diseases not only in humans but also in terrestrial and aquatic animals. For this reason, it is used as a nutritional supplement for humans, and is added to mixed feed for livestock and aquaculture.

L-ascorbic acid is used not only in the nutritional aspects of humans and animals, but also as an organic acid in the food industry, as an acidulant, an antioxidant, and a modifier for wheat flour.

In this way, L-
The disadvantage of ascorbic acid and its salts is that they are highly susceptible to oxidation. It is particularly easy to decompose in aqueous solutions or in the presence of metals and various minerals.

Particularly in recent years, as the cultivation of fish and the like has become more popular, the use of artificial compound feed for fish cultivation has increased and become widespread.

Generally, unlike land animals, fish do not have indigenous bacterial groups that biosynthesize vitamins in their intestines, so it is necessary to mix various vitamins into their feed during cultivation.

However, the L-ascorbic acid (so-called vitamin C) added in this case is extremely unstable, especially in feed due to the coexistence of liver powder, water, and minerals, and is easily decomposed and lost, resulting in nutritional nutrition. The academic purpose will not be achieved.

Conventionally, as a countermeasure against this problem, L-ascorbic acid or its salts are coated with a coating agent such as oil or fat and oil and an emulsifier to shield it from moisture, minerals, air, etc. - Attempts have been made to prevent the decomposition of ascorbic acid and its salts. For example, as this coating material,
Melt of fat and oil and lecithin or fat and oil, lecithin and glycerin fatty acid monoester (Japanese Patent Application Laid-Open No. 127819-1982)
, Melt of oil and fat and roasted sugar fatty acid ester (Unexamined Japanese Patent Publication No. 1983-
109962).

``Problems to be Solved by the Invention'' However, in these patent applications, coatings that use both oil and lecithin as coating agents often change color when stored for a long time because they contain lecithin; Coating agents that use sucrose fatty acid esters in combination have drawbacks such as the high cost of sucrose fatty acid esters. Furthermore, when a hardened animal or vegetable oil is used alone as a coating agent, the coating performance is insufficient, and in the presence of moisture, L-ascorbic acid easily dissolves, resulting in insufficient coating performance.

"Means for Solving the Problems" The present inventors have developed a formulation of L-ascorbic acid and salts coated with oil and fat that has sufficient coating performance without using these so-called emulsifiers. As a result of intensive research aimed at
When L-ascorbic acid was coated by adding a smaller amount of glycerin fatty acid monoester to oil than the amount used in Comparative Example 9, the coating performance (judged by the elution rate of the core substance) was rather improved. They found this surprising effect and completed the present invention.

The present invention provides a coating material comprising L-ascorbic acid or its salts, 100 parts of fat and oil having a melting point of 50 to 80°C, and 1 to 8 parts by weight of a glycerin fatty acid ester selected from the group consisting of glycerin fatty acid monoesters or diesters. It consists in an L-ascorbic acid preparation coated with.

As the core substance of the L-ascorbic acid preparation used in the present invention, not only I,-ascorbic acid but also its salts are used. Salts of L-ascorbic acid include alkali metal or alkaline earth metal salts such as its sodium salt or calcium salt. These ascorbic acids and their salts can be used alone or in mixtures.

The particle size of this core substance is generally 80 μm or less, preferably 30 μm or less, more preferably 3 to 2 μm as an average particle size.
It is 0 μm. If the particle size is large, the coating will be insufficient, and if the particle size is small, it is not economical.

The fats and oils with a melting point of 50 to 80°C used in the present invention include hydrogenated beef tallow oil, hydrogenated chigin oil, hydrogenated rapeseed oil, hydrogenated castor oil, hydrogenated whale oil, hydrogenated palm oil, hydrogenated soybean oil, coconut oil, etc. be.

The glycerin fatty acid ester in the present invention may also be used as a monoester, a diester, or a mixture thereof, and one or more types thereof are appropriately selected from the group of these various compounds. The fatty acid component preferably has 8 to 22 carbon atoms, and may be saturated or unsaturated, but glycerides of saturated fatty acids are used for boat fishing. Examples of the glycerin fatty acid ester include monoesters such as lauric acid monoester, myristic acid monoester, valmitic acid monoester, and stearic acid monoester, or diesters such as lauric acid diester, myristic acid diester, palmitic acid diester, and stearic acid diester. However, general practical commercial products are produced by transesterification of edible oils and fats and glycerin. In this method, the monoester content is 48-69χ
The remainder is mainly diglyceride, and to further increase the monoester content, molecules of 907 or higher can be obtained by molecular distillation. These commercially available products are mixed monoglycerides of two or more types of the above-mentioned fatty acids, and are preferably used in the present invention. As the glycerin fatty acid ester of the present invention, any of these monoesters or a mixture of monoesters and diesters can be used.

The amount of glycerin fatty acid ester used is 1 to 10 parts by weight, usually 1 to 8 parts by weight, preferably 1.5 to 7.5 parts by weight, and more preferably 1.5 to 4 parts by weight, based on 100 parts by weight of oil or fat.
．． It is 5 parts by weight. If the amount of glycerin fatty acid monoester used is too small, the coating effect (for example, the results of the so-called dissolution rate test, which examines the extent to which the core material dissolves in water) will be poor, and if it is too large, the coating effect (dissolution rate) will decrease. .

The coating material is composed of an oil or fat having a melting point of 50 to 80 DEG C. and the above-mentioned glycerin fatty acid ester, which are usually mixed and melted by heating before use. The amount of this coating material used is L
-0.5-20 for ascorbic acid or its salts
The magnification is usually 1 to 10 m1, preferably 2 to 5 times by weight.

The L-ascorbic acid preparation of the present invention can be produced by known coating methods such as a spray cooling method or a method in which a coating solution dissolved in an organic solvent is sprayed into a fluidized core material and granulated while the solvent is evaporated. Although various methods can be mentioned, the spray cooling method is industrially preferred. For example, the coating material is about 70-80%
After melting the core material by heating and dispersing it uniformly, it is sprayed into a room adjusted to below 40°C, preferably below 35°C, using a rotating disc type granulator. Particle size 200-700 μm, preferably 200-500 μm
A method of granulating into micro-particles of μm size is adopted. The particle size of the coating can be determined by, for example, sieving so that it falls within a preferable particle size range in consideration of coating performance.

"Action" The L-ascorbic acid preparation of the present invention can be used as a quality improver for medicines, foods, livestock and farmed fish feed, or as an L-ascorbic acid (vitamin C) reinforcing agent. Even if the materials, such as food or feed materials, are in a dry state or in a wet state, the purpose can be sufficiently achieved by easily mixing them.

Moreover, it is possible to add other base materials such as minerals that decompose L-ascorbic acid.

"Effects of the Invention" The L-ascorbic acid preparation of the present invention uses cheaper raw materials than conventional ones and does not use expensive emulsifiers, and has an extremely industrially important effect of effectively exerting the coating effect inherent to fats and oils. be able to.

Next, the present invention will be explained in detail with reference to Examples. However, in the examples, "parts and r%J" are used unless otherwise specified.
"parts by weight" and "% by weight".

"Example j Examples 1 to 4 Hydrogenated beef tallow and 1 part, 2 parts, 3 parts for 100 parts of this fat
part and 5 parts of glycerin fatty acid monoester (
Total monoglyceride content 95% or more, myristic acid 20%
~30χ, a commercially available product containing stearic acid 60~70χ) was melted and maintained at a temperature of 80°C, and L-ascorbic acid crystal particles with an average particle size of about 20 μm were mixed with a core material content of about 30χ. Mix uniformly, spray into a room at 25-35°C using a rotating disc type sprayer, sieve and add 200-600 μl11 (average particle size 380 μm).
) coated particles were obtained.

Example 5 Hydrogenated beef tallow oil and glycerin fatty acid monoester at a ratio of 2 parts to 100 parts of this oil (total monoglyceride content 61-66%, most of the rest being diglyceride; composition of fatty acid components: myristic acid 20-30x , a commercially available product consisting of 55-65χ of stearic acid) was melted and maintained at a temperature of 80°C, and L-ascorbic acid crystal particles with an average particle size of 20 μm were mixed with a core material content of about 30χ.
Mix uniformly and spray into a room at 25 to 35°C using a rotating disk type sprayer, and sieve to obtain a coating with an average particle size of 380 μm (shi-ask = 11 = lupic acid preparation) ) was obtained.

In order to test the coating performance of this coating, the dissolution rate was measured by the method of the experimental example.

Comparative Examples 1-2 The same procedure as in Example 1 was carried out except that the glycerin fatty acid monoester was not added in Example 1 and the amount of the glycerin fatty acid monoester was 14 parts based on 100 parts of fat or oil.

Experimental Examples After the coatings of Examples 1 to 5 and Comparative Example were granulated at room temperature for one day, the following test was conducted on the dissolution rate of the coatings.

Using a shaker capable of reciprocating vibrations at a vibration frequency of 110 times/min and an amplitude of 50 mm, the coating and about 80 times the amount of stabilizer water were placed in a glass container, and shaken at 30°C for 30 minutes. After filtration, the content of L-ascorbic acid in the filtrate was determined to determine the elution rate of the core substance, and the results shown in Table 1 below were obtained.

-12=Example 6 Similar results were obtained in Examples 1 to 6 using a calcium salt of L~ascorbic acid instead of L-ascorbic acid.

Patent applicant: Kawasaki Chemical Industries, Ltd.

Claims (12)

[Claims] (1) L-ascorbic acid or its salts with a melting point of 50
An L-ascorbic acid preparation coated with a coating agent consisting of 100 parts of oil and fat at ~80°C and 1 to 10 parts by weight of a glycerin fatty acid ester selected from the group consisting of glycerin fatty acid monoesters or diesters. (2) The L-ascorbic acid preparation according to claim 1, wherein the amount of glycerin fatty acid ester is 1 to 8 parts by weight per 100 parts by weight of oil or fat. (3) The L-ascorbic acid preparation according to claim 1, wherein the amount of glycerin fatty acid ester is 1.5 to 7.5 parts by weight per 100 parts by weight of oil or fat. (4) The L-ascorbic acid preparation according to claim 1, wherein the amount of glycerin fatty acid ester is 1.5 to 4.5 parts by weight per 100 parts by weight of oil or fat. (5) The L-ascorbic acid preparation according to claim 1, wherein the fat or oil is a hydrogenated oil. (6) L according to claim 1, wherein the fat or oil is hydrogenated beef tallow oil, hydrogenated chicken oil oil, hydrogenated rapeseed oil oil, hydrogenated castor oil oil, hydrogenated whale oil oil, hydrogenated palm oil oil, hydrogenated soybean oil oil, or coconut oil. - Ascorbic acid preparations. (7) Glycerin fatty acid esters are monoesters such as lauric acid monoester, myristic acid monoester, palmitic acid monoester, and stearic acid monoester, and diesters such as lauric acid diester, myristic acid diester, palmitic acid diester, and stearic acid diester. An L-ascorbic acid preparation according to claim 1. (8) The L-ascorbic acid preparation according to claim 1, 2, 3, 4, or 7, wherein the glycerin fatty acid ester is a glycerin fatty acid monoester. (9) The L-ascorbic acid preparation according to claim 1, wherein the coating method is a spray cooling method. (10) The L-ascorbic acid preparation according to claim 1, wherein the coating method is a rotating disk spray cooling method. (11) The method according to claim 1, 9, or 10, wherein the average particle size of L-ascorbic acid or its salt is 3 to 20 μm. (12) Particle size of L-ascorbic acid preparation is 200-50
Claim 1, 9 or 10 which is 0 μm
The L-ascorbic acid preparation described in .