JPH01275765A - Production of implant material - Google Patents
Production of implant materialInfo
- Publication number
- JPH01275765A JPH01275765A JP10605788A JP10605788A JPH01275765A JP H01275765 A JPH01275765 A JP H01275765A JP 10605788 A JP10605788 A JP 10605788A JP 10605788 A JP10605788 A JP 10605788A JP H01275765 A JPH01275765 A JP H01275765A
- Authority
- JP
- Japan
- Prior art keywords
- sol
- metal
- implant material
- soln
- fine powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000463 material Substances 0.000 title claims abstract description 16
- 239000007943 implant Substances 0.000 title claims abstract description 9
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 229910052751 metal Inorganic materials 0.000 claims abstract description 12
- 239000002184 metal Substances 0.000 claims abstract description 12
- 239000005312 bioglass Substances 0.000 claims abstract description 8
- -1 alkyl silicate Chemical compound 0.000 claims abstract description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 5
- 238000010304 firing Methods 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 4
- 239000010935 stainless steel Substances 0.000 abstract description 4
- 239000000853 adhesive Substances 0.000 abstract description 3
- 230000001070 adhesive effect Effects 0.000 abstract description 3
- 210000000988 bone and bone Anatomy 0.000 abstract description 3
- 229910001220 stainless steel Inorganic materials 0.000 abstract description 3
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 abstract description 2
- 238000001354 calcination Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229910052586 apatite Inorganic materials 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241000288976 Arcina Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229910000599 Cr alloy Inorganic materials 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- VHHVGPDQBHJHFB-UHFFFAOYSA-N [Ti].[Cr].[Ni] Chemical compound [Ti].[Cr].[Ni] VHHVGPDQBHJHFB-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000000788 chromium alloy Substances 0.000 description 1
- UMUXBDSQTCDPJZ-UHFFFAOYSA-N chromium titanium Chemical compound [Ti].[Cr] UMUXBDSQTCDPJZ-UHFFFAOYSA-N 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910000623 nickel–chromium alloy Inorganic materials 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 229910001256 stainless steel alloy Inorganic materials 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C18/00—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating
- C23C18/02—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition
- C23C18/12—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
- C23C18/1229—Composition of the substrate
- C23C18/1241—Metallic substrates
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C18/00—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating
- C23C18/02—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition
- C23C18/12—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
- C23C18/1204—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material inorganic material, e.g. non-oxide and non-metallic such as sulfides, nitrides based compounds
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C18/00—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating
- C23C18/02—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition
- C23C18/12—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
- C23C18/125—Process of deposition of the inorganic material
- C23C18/1254—Sol or sol-gel processing
Landscapes
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Glass Melting And Manufacturing (AREA)
- Chemically Coating (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は人工歯、人工骨として用いられうるインプラン
ト材の製造方法に関する。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a method for manufacturing an implant material that can be used as an artificial tooth or bone.
（従来の技術）
従来のインプラント材は、セラミックス２０、（１９８
５）Ｎｏ １２、Ｐ４Ｏ１０に記載されているように、
生体許容性（ポリエチレン、ステンレス鋼）、生体不活
性（アルシナ、カーボン）、生体活性（アパタイト、Ｔ
ＣＰ、Ｃａ＜ Ｏ（Ｐｏ、）１）の３種類の材料が有り
だ。(Prior art) Conventional implant materials include ceramics 20, (198
5) As stated in No. 12, P4O10,
Bioacceptance (polyethylene, stainless steel), bioinertness (arcina, carbon), bioactivity (apatite, T
There are three types of materials: CP, Ca<O(Po,)1).
（発、明が解決しようとする課題〕
しかし、前述の従来技術にはそれぞれ次のような問題点
を有しているため、一般に広くは普及していない。(Problems to be Solved by the Invention) However, the above-mentioned conventional techniques each have the following problems, and therefore are not widely used.
生体許容性及び生体不活性材料の場合は、骨と直接結合
することなく１機械的なはめこのみによってのみ固定さ
れているだけなので、長期間使用でゆるみや脱落の恐れ
がある。In the case of bioacceptable and bioinert materials, they are not directly bonded to the bone and are fixed only by a single mechanical fit, so there is a risk of loosening or falling off after long-term use.
一方、生体活性材料の場合は、特にアパタイトでは圧縮
強度は十分であるが、引張り、曲げ、ねじり強度か不十
分である。従って過大な引張り応力のかかる部位には使
用できない。On the other hand, in the case of bioactive materials, especially apatite, the compressive strength is sufficient, but the tensile, bending, and torsional strengths are insufficient. Therefore, it cannot be used in areas subject to excessive tensile stress.
このようなことから、生体親和性を損なわないて材料強
度を向上させる試みかなされている。この試みについて
は今だに実用レベルまで達っしたという報告は一件もな
く、開発中である。For this reason, attempts have been made to improve material strength without impairing biocompatibility. There are no reports of this attempt reaching a practical level yet, and it is still under development.
この試みの一つの方法としては、ステンレスやチタン合
金の表面にバイオガラスをコーティングすることで１強
度と生体親和性を同時に満足する材料を作成するものが
有る。この問題点は、コーティング膜と金属との間の接
着強度が弱いことと、従来はコーティングをバイオガラ
スの溶融で行っていたのであるか、作業性か悪く、量産
性がないという問題点を有していた。One method of attempting this is to create a material that satisfies both strength and biocompatibility by coating the surface of stainless steel or titanium alloy with bioglass. This problem is due to the weak adhesive strength between the coating film and the metal, and the fact that coating has traditionally been done by melting bioglass, which has poor workability and is not suitable for mass production. Was.
そこで、本発明は、このような問題点を解決するものて
、その目的とするところは、金属の表面に容易に、接着
力の強いバイオガラスの膜を形成する方法を提供するこ
とにある。SUMMARY OF THE INVENTION The present invention aims to solve these problems, and its purpose is to provide a method for easily forming a bioglass film with strong adhesive strength on a metal surface.
〔課題を解決するための手段）
本発明のインプラント材の製造方法は、金属表面に以下
の工程てバイオガラスをコーティングしたことを特徴と
する。[Means for Solving the Problems] The method for manufacturing an implant material of the present invention is characterized in that a metal surface is coated with bioglass in the following steps.
ａ）アルキルシリケートの加水分解溶液にハイドロキシ
アパタイトの微粉末を添加しゾルとする工程、
ｂ）金属表面に前記ゾルを塗布する工程、Ｃ）前記コー
ティング物を乾燥し、適当な温度て焼成する工程。a) A step of adding fine powder of hydroxyapatite to a hydrolyzed solution of alkyl silicate to form a sol, b) A step of applying the sol to a metal surface, C) A step of drying the coated material and firing it at an appropriate temperature. .
エチルシリケート１モルに、エチルアルコール１００ｍ
見、０．１規定の塩酸水溶液を３２ｍ文加天上くかきま
ぜた。加水分解反応終了後に、ハイドロキシアパタイト
の粉末を１．５モルを加えよく混合した。また、膜厚コ
ントロールのため粘土を大きくするために、エチレング
リコール等の増粘剤を必要ならば添加した。1 mole of ethyl silicate, 100 m of ethyl alcohol
A 0.1 N aqueous solution of hydrochloric acid was stirred over a 32-meter cylinder. After the hydrolysis reaction was completed, 1.5 mol of hydroxyapatite powder was added and mixed well. In addition, a thickener such as ethylene glycol was added if necessary to increase the size of the clay in order to control the film thickness.
このゾルに、ステンレスや、チタン、チタン−クロム合
金、チタン−ニッケルークロム合金等の材質の金属棒を
浸し、ディッピングによりコーティングした。つづいて
、６０℃で乾燥した後、３５０°Ｃに加熱してバイオガ
ラスのコーティング膜にした。A metal rod made of stainless steel, titanium, titanium-chromium alloy, titanium-nickel-chromium alloy, or the like was immersed in this sol and coated by dipping. Subsequently, it was dried at 60°C and heated to 350°C to form a bioglass coating film.
得られたインプラント材は、生体親和性と強度を十分に
兼ね備えており、実用化可能なものであった。The obtained implant material had sufficient biocompatibility and strength, and was suitable for practical use.
（発明の効果）
以上述べたように本発明によれば、ゾル−ゲル法のゾル
にパイトロキシアパタイトを添加し、この溶液を金属に
コーティングすることにより、バイオガラスを金属の表
面に固くコーティングすることかでき、生体親和性及び
強度の優れたインプラント材にすることかてきる。(Effects of the Invention) As described above, according to the present invention, pytroxyapatite is added to the sol of the sol-gel method and the metal is coated with this solution, thereby firmly coating the surface of the metal with bioglass. This allows it to be used as an implant material with excellent biocompatibility and strength.
以上 出願人 セイコーエプソン株式会社that's all Applicant: Seiko Epson Corporation
Claims (1)
したことを特徴とするインプラント材の製造方法。 ａ）アルキルシリケートの加水分解溶液にハイドロキシ
アパタイトの微粉末をを添加しゾルとする工程、 ｂ）金属表面に前記ゾルを塗布する工程、 ｃ）前記コーティング物を乾燥し、適当な温度で焼成す
る工程。[Claims] A method for producing an implant material, characterized in that a metal surface is coated with bioglass in the following steps. a) Adding fine powder of hydroxyapatite to a hydrolyzed solution of alkyl silicate to form a sol; b) Applying the sol to a metal surface; c) Drying the coated material and firing it at an appropriate temperature. Process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10605788A JPH01275765A (en) | 1988-04-28 | 1988-04-28 | Production of implant material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10605788A JPH01275765A (en) | 1988-04-28 | 1988-04-28 | Production of implant material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01275765A true JPH01275765A (en) | 1989-11-06 |
Family
ID=14423989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10605788A Pending JPH01275765A (en) | 1988-04-28 | 1988-04-28 | Production of implant material |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01275765A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996029447A1 (en) * | 1995-03-22 | 1996-09-26 | Queen's University At Kingston | Method for producing thick ceramic films by a sol gel coating process |
| US5762950A (en) * | 1990-06-25 | 1998-06-09 | Orion-Yhtyma Oy | Bioceramic system for delivery of bioactive compounds |
-
1988
- 1988-04-28 JP JP10605788A patent/JPH01275765A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5762950A (en) * | 1990-06-25 | 1998-06-09 | Orion-Yhtyma Oy | Bioceramic system for delivery of bioactive compounds |
| WO1996029447A1 (en) * | 1995-03-22 | 1996-09-26 | Queen's University At Kingston | Method for producing thick ceramic films by a sol gel coating process |
| USRE36573E (en) * | 1995-03-22 | 2000-02-15 | Queen's University At Kingston | Method for producing thick ceramic films by a sol gel coating process |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4223412A (en) | Implants for bones, joints or tooth roots | |
| US5609633A (en) | Titanium-based bone-bonding composites having inverted concentration gradients of alkali and titanium ions in a surface layer | |
| CA1109579A (en) | Curable compositions | |
| US4483678A (en) | Dental implant for attachment of artificial tooth | |
| JPH02255515A (en) | Coating method for bioactive hydroxylapatite film | |
| JPH0624585B2 (en) | Biocompatible composite manufacturing method | |
| JPS6241662A (en) | Biologically active composite material for artificial prosthetic purpose | |
| AU8434898A (en) | Hydroxylapatite gel | |
| JPH062154B2 (en) | Powder for coating calcium phosphate-based substance, coating method and composite bioceramics | |
| JPH042355A (en) | Ceramic body having biologically active surface layer and production thereof | |
| JP2003512895A (en) | Hard tissue repair material and method for producing the same | |
| JPH01275765A (en) | Production of implant material | |
| KR100424910B1 (en) | Coating process of bioactive ceramics | |
| JPH01275766A (en) | Production of implant material | |
| JP2664029B2 (en) | Calcium phosphate coated titanium material | |
| JPH01275764A (en) | Implant material manufacturing method | |
| JPH01275767A (en) | Implant material manufacturing method | |
| JPH028370A (en) | Implant material manufacturing method | |
| JPH01277554A (en) | Preparation of implant material | |
| JP2775523B2 (en) | Bone substitute material and its manufacturing method | |
| JP2623315B2 (en) | Calcium phosphate coated ceramics and method for producing the same | |
| JPH0244275B2 (en) | ||
| JPH0670974A (en) | Manufacture of living body activating composite implant material | |
| JPH09122223A (en) | Organism implant material and manufacture thereof | |
| JPH0438959A (en) | Calcium phosphate cover material |