JPH01228911A - Method for manufacturing multidirectional stretchable patch - Google Patents

Abstract

PURPOSE:To provide a plaster not being peeled and capable of following the movement of skin when adhered to the skin, by forming the layer of a polyvalent metal salt on the surface of a nonwoven fabric stretchable in multi- directions and coating a plaster material containing a water-dissolvable polymer thereon. CONSTITUTION:The surface of a nonwoven fabric stretchable in multi-directions is coated or sprayed with an organic solvent dispersion of a polyvalent metal salt and/or polyvalent metal hydroxide (the polyvalent metal is preferably Al, Ca or Mg) and subsequently dried to form the layer of the polyvalent metal salt and on the formed layer a plaster material containing a water-soluble polymer (e.g., CMC-Na or polyacrylic acid) is coated to provide a plaster stretchable in multi-directions. The plaster material cures without penetrating into the deep portions of the nonwoven fabric, thereby not inhibiting the stretchability of the nonwoven fabric. The amount of the polyvalent metal salt forming the layer is preferably a range of 1.0X10<-7>-1.0X10<-4>mol/cm<2> as the amount of the Al or a range of 1.5X10<-7>-1.5X10<-4>mol/cm<2> as the amount of the Ca or Mg.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Application] The present invention relates to a method for producing a patch, which is a pharmaceutical product, to be applied to the surface of the human body, and more specifically to a method for producing a multidirectionally stretchable patch.

[Conventional technology]

Conventionally, Nozzo agent and Silastar agent have been frequently used as patches applied to the skin. In recent years, research has progressed in the field of plasters for e-tubes, and dramatic improvements have been made in terms of adhesion to the skin, resistance to perspiration (prevention of so-called dripping, sweat dripping), etc. In particular, regarding adhesive strength, in the past the adhesive strength was weak and it would peel off from the skin during use, so it was necessary to fix it with a glaze layer etc. when applying it to the skin, but now the adhesive strength is low. Products with improved performance and resistance to peeling during use are now on the market. However, the lint cloth or non-woven fabric conventionally used as the backing material for Notuzo agents does not have much elasticity, so when it is applied, it causes movement of the human skin, which is the layered body. , sometimes unable to keep up with the movements of the joints,
Occasionally, it would peel off from the skin. In order to solve this problem, a unidirectional stretch nonwoven fabric or knitted fabric was used. Q bulges are on the market.

[Problem to be solved by the invention]

However, unidirectional stretch nonwoven fabrics or knitted fabrics only have elasticity in one direction, so when pasting them on joints, etc., the direction of stretch must be checked before use. If the affected area is spread vertically, there is the inconvenience that one piece cannot cover the affected area. In addition, it lacks the ability to follow the skin in directions that do not stretch and contract, and in severe cases may even separate from the skin.

In order to solve this problem, the present inventors created an indestructible fabric that is stretchable in all directions (so-called multidirectional stretchable nonwoven fabric) so that the backing does not inhibit the ability of the anti-inflammatory agent to follow the skin. We conducted repeated research to use it as a backing for NoQ Tsude agent. As a result of examining the degree of stretch of the skin, it was found that the skin of 5crR stretches to about &51 at the joints where the degree of stretch is considered to be the greatest (elbow extension side and knee extension side). However, machine direction and trough 2-
50% 0% modulus length 50 w
x 200 m) is 0.4 K-p/5 cm
When a plaster of 79 Tsuzo agent was applied to the following so-called multidirectional stretchable nonwoven fabric, a part of the plaster penetrated too deeply into the nonwoven fabric, causing the plaster to fill between the fibers of the nonwoven fabric, causing the corpus luteum itself and Although the nonwoven fabric itself has sufficient elasticity, as a result, the elasticity of the nonwoven fabric was significantly inhibited, and the inventors were unable to obtain the multidirectional elasticity and 9-layer agent that the inventors had originally aimed for. (Figure 1).

[Means to solve the problem]

In order to solve these problems, the present inventors have conducted extensive research and found that polyvalent metal groups and/or friends formed on the surface of a multidirectional stretchable nonwoven fabric are formed on a layer consisting of a polyvalent metal hydroxide. By applying a plaster containing water-soluble polymer to
The present invention was completed based on the discovery that the plaster surface hardens at the point of contact with the nonwoven fabric immediately after application, and does not penetrate deeper into the nonwoven fabric than necessary, so that the elasticity of the multidirectional stretchable nonwoven fabric is not inhibited. This is what led to this.

That is, the present invention provides a multidirectional multi-layer structure in which a corpus luteum containing a water-soluble polymer is applied onto a layer of a multivalent metal salt and/or a multivalent metal hydroxide formed on the surface of a multidirectionally stretchable nonwoven fabric. A method for manufacturing a directionally stretchable patch is provided.

Examples of polyvalent gold M salts or polyvalent metal hydroxides that can be used in the present invention include salts or hydroxides of at least one polyvalent metal selected from aluminum, calcium, and magnesium. Specifically, aluminum chloride, aluminum sulfate, aluminum acetate, aluminum oxide, potassium alum (potassium aluminum sulfate)
, ammonium alum, dihydroxyaluminum aminoacetate, albanium allantoinate, magnesium aluminate metasilicate, aluminum silicate, aluminum hydroxide and other aluminum salts and hydroxides; calcium chloride, calcium hydroxide, calcium oxide. , calcium salts or hydroxides such as calcium carbonate; magnesium salts or hydroxides such as magnesium oxide, magnesium hydroxide, magnesium chloride, magnesium sulfate, magnesium carbonate, and magnesium silicate. Among these, aluminum chloride, JAr&aluminum, potassium alum (potassium aluminum sulfate) are used in the present invention because of their high solubility in water.
, ammonium alum, aluminum hydroxide, dihydroxyaluminum aminoacetate, calcium hydroxide, magnesium chloride, magnesium sulfate, etc. are preferably used. These can be used alone or in combination of two or more.

The t of the polyvalent metal salt and/or polyvalent metal hydroxide formed on the multidirectional stretchable subsurface is 1.0×10 −7 to 1.0×1. OX l O-'
mol/c! 11 Calcium or magnesium amount: 1.5 x 10-y ~ L5X10-4 mat/
A range of d is preferred. If it is less than this range, it is too small to act as a barrier against the intrusion of the corpus luteum into the nonwoven fabric, and if it exceeds this range, the corpus luteum will be excessively hardened and the stretchability of the entire agent will be inhibited.

The method of forming polyvalent metal salts and/or polyvalent metal hydroxides on the surface of a multidirectional stretchable nonwoven fabric is not particularly limited, but it has been reported that dry streaks occur after spraying when applied as a solvent dispersion. The method is common.

The water-soluble polymer in the corpus luteum used in the present invention is as follows:
Examples include sodium carboxymethyl cellulose, sodium alginate, polyacrylate, sodium polyacrylate, and carboxyvinyl polymer, which can be used alone or in combination in a total of 0.1 to 20% by weight in the corpus luteum. , preferably 1 to 10'' iL %.

[Action and effect of the invention]

As described above, in the present invention, in order to perform coating after forming a layer of polyvalent metal salt and/or hydroxide on the surface of a multidirectional stretchable nonwoven fabric, a plaster containing a water-soluble polymer is applied. In this case, the paste does not penetrate deep into the nonwoven fabric and hardens, so that the elasticity of the fabric is not inhibited. As a result, when applied to the skin, it can expand and contract according to the movement of the skin, so the effects of the medicinal ingredients containing M can be fully utilized without peeling off from the skin.

〔Example〕

Examples of the present invention will be shown below and explained in more detail.

Example 1 Ammortum alum 1 Jtfi 0, 15 p/5 cm, machine direction 0, 4 915 cIR 50% 0% modular section length 5.

■X200■) multi-directional stretchable nonwoven fabric with mini'7A amount L O X I O-', 5.0XIO-5
.

1, O x 1 0-' mol/-, 111 cm
Cloth L was dried.

Example 2 A dispersion of 1% by weight of calcium hydroxide in ethanol was added in the traverse direction at 0.0%. l 5 kp/ 5 al
l, 0 for machine direction. 50 of 4KP151
%0% modular section length 50m x 200 days) multi-directional stretchable nonwoven fabric with a calcium content of 1.5 x 10°7, 7.
It was applied at a concentration of 5×10 and 1.5×10 −4 mol/− and dried.

Example 3 A 1% by weight ethanol dispersion of magnesium sulfate was added to the traverse direction at a rate of 0.15 yu/5 tym.
0 for machine direction. 4 Lt/51 of 5
A multidirectional stretchable nonwoven fabric with a modular section length of 50 m x 200 cm) has a magnesium content of 1.5 x 10-1,
7.5×10 −′, L5×10 −7 to 1.0×10 − and dried.

Example 4 An ethanol dispersion of 5% by weight of aluminum sulfate and 1% by weight of aluminum hydroxide was added to the traverse direction.
．． 1 5 h# / 5 cns, 0. to machine direction. 4 D / 5 cm 50% 0% modular length 50 x 200) fr. The multidirectional stretchable indestructible fabric has a total aluminum content of LOXIO-',5. O
Xl 0-', 1. It was coated to give OXl 0-'nol/- and dried.

Comparative Example 1 In Example 1, aluminum 9mm was 1.0X10-1L.
It was applied and dried in the same manner except that the amount of OX10-'' mol/- was changed.

Comparative Example 2 In Example 2, the amount of calcium was 1.5X10-8, 1
, 5×10-” mol/ad, and dried in the same manner.

Comparative Example 3 In Example 3, the amount of magnesium was 1.5×10°8,
The coating was applied in the same manner except that the amount was 1.5 x 10-'' mol/- and dried.

Comparative Example 4 In Example 4, the amount of aluminum was 1.0 x 10-$,
1. It was applied and dried in the same manner except that OX 10-3 mopl- was used.

2% by weight of sodium carboxymethyl cellulose as water-soluble straw molecules and polyacrylic nitrate were added to the multidirectional stretchable nonwoven fabric on which polyvalent metal 1 and/or hydroxide were formed on the surface shown in Test Examples 1 to 4. 0.1P of 11 e-tubers containing 7% sodium and 40% water by weight
/ffl was applied to obtain a patch.

In addition, the same padding agent was applied to the stretchable nonwoven fabric used in Examples 1 to 4 (without 7m of polyvalent gold striped salt and/or hydroxide formed on the surface) at a rate of 0.15'/leak. expand,
This was referred to as Comparative Example 5.

Using an elongation tester (Sun Rheometer: ■Sun Scientific),
Each patch was subjected to an extension test in the traverse direction (attempt: 50w x 200mm, extension speed: 20wm)
/min) was performed.

Test results Figure 1 shows the results of the elongation test for the multi-directional elasticity b itself, the mounting body itself used in practical examples and comparative examples, and the comparative example 50 attachment rule.
Figure 2 shows the results of the elongation test of the patch of Example 1 and Comparative Example 1, Figure 3 shows the results of the elongation test of the patch of Example 2 and Comparative Example 2, and the results of the elongation test of the patch of Example 3 and Comparative Example 3. The results of the elongation test are shown in FIG. 4, and the results of the elongation test of the patches of Example 4 and Comparative Example 4 are shown in FIG.

From FIGS. 1 to 5, it can be seen that the surface according to the present invention has a polyvalent metal salt and/or
The adhesive patch using a multi-directionally stretchable nonwoven fabric with a hydroxide layer or a hydroxide layer clearly showed a good elongation rate, demonstrating the superiority of the present invention.

[Brief explanation of the drawing]

FIGS. 1 to 5 are drawings showing the results of an elongation test performed on each adhesive patch of Examples and Comparative Examples. that's all

Claims (1)

[Claims] 1. A plaster containing a water-soluble polymer is applied on a layer of polyvalent metal salt and/or polyvalent metal hydroxide formed on the surface of a multidirectional stretchable nonwoven fabric. A method for producing a multi-directional stretchable patch. 2. Production of the multidirectional stretchable patch according to claim 1, wherein the polyvalent metal of the polyvalent metal salt and/or polyvalent metal hydroxide is at least one metal selected from aluminum, calcium, and magnesium. Method. 3. The amount of aluminum in the layer formed on the surface of the multidirectional stretchable nonwoven fabric is 1.0 x 10^-^7 to 1.0 x 10^-
The method for producing a multi-directional stretchable patch according to claim 1 or 2, wherein the amount is ^4 mol/cm^2. 4. The amount of calcium present in the layer formed on the surface of the multidirectional stretchable nonwoven fabric is 1.5 x 10^-^7 to 1.5 x 10^-^
4 mol/cm^2 The method for producing a multidirectional stretchable patch according to claim 1 or 2. 5. The amount of magnesium present in the layer formed on the surface of the multidirectional stretchable nonwoven fabric is 1.5 x 10^-^7 to 1.5 x 10^-
The method for producing a multi-directional stretchable patch according to claim 1 or 2, wherein the amount is ^4 mol/cm^2.