JP7367596B2 - Chip devices, chip container sets, chip electrode devices and chip electrode sets - Google Patents

Description

The present disclosure relates to a chip device, a chip container set, a chip electrode device, and a chip electrode set.

For example, tubular tips as described in Patent Documents 1 to 4 are known.

Patent No. 5317983 Patent No. 6090387 JP2019-33680A Japanese Patent Application Publication No. 11-295282

Such chips may be used for purposes such as measurement, injection, and collection of samples such as cells as described below. First, liquid is introduced from the rear end of the chip. Next, the chip is held in a container that accommodates the chip. The container is then centrifuged, and the tip of the chip is filled with liquid without any gaps, that is, without air bubbles. Then, the chip is removed from the container and checked using a microscope to see if the tip of the chip is filled with liquid without any gaps. If the liquid is not completely filled, centrifuge the chip again. When it is confirmed that the liquid is filled without any gaps, a linear electrode is introduced from the rear end of the chip, and the rear end of the chip is held in an electrode holder. This causes the tip of the electrode to be immersed in the liquid within the tip of the tip. By dipping the tip of the tip into the sample and applying an electric field between the sample and the electrode, the various purposes described above can be achieved.

However, conventional chips cannot be easily attached to and detached from either the container or the electrode holder.

Therefore, an object of the present disclosure is to provide a chip device that allows a chip to be easily attached and detached from a container, a chip device that allows a chip to be easily attached and detached from an electrode holder, and a chip container set that allows a chip to be easily attached and detached from a container. Another object of the present invention is to provide a tip electrode device that allows a tip to be easily attached to and removed from an electrode holder, and a tip electrode set that allows a tip to be easily attached to and removed from an electrode holder.

A tip device according to some embodiments includes a tubular tip and a base that is connected to a rear end of the tip and includes a first connection portion, the first connection portion being connected to a container containing the tip. It is removably connected to a provided second connection portion. According to such a configuration, the chip can be easily attached to and detached from the container via the base.

A tip device according to some embodiments includes a tubular tip and a base that is connected to a rear end of the tip and includes a first connection portion, the first connection portion being provided on an electrode holder. The electrode holder is removably connected to the second connection part and projects a linear electrode introduced into the rear end of the chip. According to such a configuration, the chip can be easily attached to and detached from the electrode holder via the base.

In the tip device according to one embodiment, the base may include a grip portion located between the first connection portion and the tip end portion of the tip and widened in the radial direction of the tip. According to such a configuration, by using the gripping part, the chip can be easily attached to and detached from the container or the electrode holder.

In one embodiment of the chip device, the base may have an access hole that communicates with the rear end of the chip. According to such a configuration, a liquid or an electrode can be easily introduced into the rear end of the chip through the access hole.

In the chip device according to one embodiment, the access hole may have a guide surface whose diameter gradually decreases toward the rear end of the chip. According to such a configuration, the guide surface allows the liquid or electrode to be introduced into the rear end of the chip more easily.

In the chip device according to one embodiment, the base may have a grounding portion that maintains the tip end of the chip away from the planar surface on which the chip is placed. According to such a configuration, when the chip is placed, contamination of the tip end of the chip can be easily suppressed.

In the chip device according to one embodiment, the grounding portion may be located on the outer peripheral surface of the base. According to such a configuration, contamination of the tip end of the chip can be easily suppressed when observing the tip end of the chip with a microscope.

In the chip device according to one embodiment, the connecting portions may be connected to each other by engagement between the projections and recesses. According to such a configuration, the chip can be reliably held by the container or the electrode holder.

In the chip device according to one embodiment, the connection parts may be connected by screwing together. According to such a configuration, the chip can be held in the container or the electrode holder more reliably.

The chip device according to one embodiment may be formed as a nanochip whose tip portion has an inner diameter on the nano-order. According to such a configuration, measurement, injection, collection, etc. of a minute portion of a sample such as an intracellular organ can be easily performed using the chip device.

A tip container set according to some embodiments includes a tubular tip, a base that is continuous with the rear end of the tip and includes a first connection part, and a second connection that is removably connected to the first connection part. and a container for accommodating the chip. According to such a configuration, the chip can be easily attached to and detached from the container via the base.

In the chip container set according to one embodiment, the container may have a communication hole that communicates the outside of the container with the rear end of the chip. According to such a configuration, liquid can be introduced from the rear end of the chip through the communication hole while the chip is housed in the container, and the liquid can be directly applied to the centrifuge. It is possible to make the work of filling liquid into the section more efficient.

In the chip container set according to one embodiment, the container may include a cap having a second connection portion and a container body including a mouth portion removably connected to the cap. According to such a configuration, the container can be configured with a simple structure.

In the chip container set according to one embodiment, the base may have a grip part located between the first connection part and the tip end of the chip and widened in the radial direction of the chip. According to such a configuration, by using the gripping part, the chip can be easily attached to and removed from the container.

In one embodiment of the chip container set, the base may have an access hole that communicates with the rear end of the chip. According to such a configuration, a liquid or an electrode can be easily introduced into the rear end of the chip through the access hole.

In the chip container set according to one embodiment, the access hole may have a guide surface whose diameter gradually decreases toward the rear end of the chip. According to such a configuration, the guide surface allows the liquid or electrode to be introduced into the rear end of the chip more easily.

In the chip container set according to one embodiment, the base may have a grounding part that maintains the tip end of the chip away from the flat surface on which the chip is placed. According to such a configuration, when the chip is placed, contamination of the tip end of the chip can be easily suppressed.

In the chip container set according to one embodiment, the grounding portion may be located on the outer peripheral surface of the base. According to such a configuration, contamination of the tip end of the chip can be easily suppressed when observing the tip end of the chip with a microscope.

In the chip container set according to one embodiment, the connecting portions may be connected to each other by engagement of projections and recesses. According to such a configuration, the chip can be held in the container more reliably.

In the chip container set according to one embodiment, the connecting portions may be connected to each other by screwing. According to such a configuration, the chip can be held in the container more reliably.

In the chip container set according to one embodiment, the chip device may be formed as a nanochip whose tip portion has an inner diameter on the nano-order. According to such a configuration, measurement, injection, collection, etc. of a minute portion of a sample such as an intracellular organ can be easily performed using the chip device.

The tip electrode device according to some embodiments includes a tubular tip, a base that is connected to the rear end of the tip and includes a first connection part, and a second connection that is removably connected to the first connection part. and a linear electrode that protrudes from the electrode holder and is introduced into the rear end of the chip. According to such a configuration, the chip can be easily attached to and detached from the electrode holder via the base.

In the tip electrode device according to one embodiment, the base may include a grip portion located between the first connection portion and the tip end portion of the tip and widened in the radial direction of the tip. According to such a configuration, by using the grip part, the chip can be easily attached to and detached from the electrode holder.

In the tip electrode device according to one embodiment, the base may have an access hole that communicates with the rear end of the tip. According to such a configuration, a liquid or an electrode can be easily introduced into the rear end of the chip through the access hole.

In the tip electrode device according to one embodiment, the access hole may have a guide surface whose diameter gradually decreases toward the rear end of the tip. According to such a configuration, the guide surface allows the liquid or electrode to be introduced into the rear end of the chip more easily.

In the tip electrode device according to one embodiment, the base may have a grounding portion that maintains a state in which the tip end of the tip is separated from the planar surface on which the tip is placed. According to such a configuration, when the chip is placed, contamination of the tip end of the chip can be easily suppressed.

In the tip electrode device according to one embodiment, the grounding portion may be located on the outer peripheral surface of the base. According to such a configuration, contamination of the tip end of the chip can be easily suppressed when observing the tip end of the chip with a microscope.

In the tip electrode device according to one embodiment, the connecting portions may be connected to each other by engagement between the concave and convex portions. According to such a configuration, the chip can be reliably held by the electrode holder.

In the tip electrode device according to one embodiment, the connection parts may be connected by screwing together. According to such a configuration, the chip can be held by the electrode holder more reliably.

In the tip electrode device according to one embodiment, the tip device may be formed as a nanochip whose tip portion has an inner diameter on the nano-order. According to such a configuration, measurement, injection, collection, etc. of a minute portion of a sample such as an intracellular organ can be easily performed using the chip device.

In the tip electrode device according to one embodiment, the electrode holder may include a first terminal that continues to the rear end of the electrode, and a second terminal that removably contacts the first terminal. According to such a configuration, when replacing the chip device held by the electrode holder, the electrode device including the electrode and the first terminal can also be replaced. Therefore, it is possible to prevent the liquid adhering to the electrodes before the chip device is replaced from mixing with the liquid in the chip device after the chip device is replaced.

A tip electrode set according to some embodiments includes a tubular tip, a base that is connected to the rear end of the chip and includes a first connection part, and a linear electrode and an electrode that are introduced into the rear end of the chip. an electrode device comprising a first terminal connected to a rear end portion, the first connecting portion is removably connected to a second connecting portion provided on the electrode holder, and the first terminal is connected to a second connecting portion provided on the electrode holder. , removably contacts a second terminal provided on the electrode holder. According to such a configuration, the chip can be easily attached to and detached from the electrode holder via the base. Moreover, according to such a configuration, when replacing the chip device held by the electrode holder, the electrode device can also be replaced. Therefore, it is possible to prevent the liquid adhering to the electrodes before the chip device is replaced from mixing with the liquid in the chip device after the chip device is replaced.

According to the present disclosure, a chip device that can easily attach and detach a chip to a container, a chip device that can easily attach and detach a chip to an electrode holder, a chip container set that can easily attach and detach a chip to and from a container, It is possible to provide a tip electrode device in which a tip can be easily attached to and removed from an electrode holder, and a tip electrode set in which a tip can be easily attached to and removed from an electrode holder.

FIG. 1 is a side view showing a chip device according to one embodiment. 2 is a cross-sectional view of the chip device shown in FIG. 1. FIG. 2 is a perspective view of the chip device shown in FIG. 1. FIG. FIG. 2 is a side view showing how the chip device shown in FIG. 1 is placed. FIG. 2 is a sectional view showing a chip container set according to one embodiment. FIG. 6 is a perspective view showing the container shown in FIG. 5 when the cap is closed. FIG. 6 is a perspective view showing the container shown in FIG. 5 when the cap is opened. FIG. 1 is a cross-sectional view showing a tip electrode device according to one embodiment. 9 is a side view of the electrode device shown in FIG. 8. FIG. It is a sectional view showing a tip container set concerning other embodiments. FIG. 11 is a perspective view showing the container shown in FIG. 10 when the closure cap is opened while the cap remains closed. FIG. 7 is a cross-sectional view showing a tip electrode device according to another embodiment in a state where an electrode terminal and a holder terminal are in contact with each other. FIG. 13 is a sectional view showing the tip electrode device shown in FIG. 12 in a state where the electrode terminal and the holder terminal are separated from each other.

Hereinafter, embodiments according to the present disclosure will be described in detail with reference to the drawings.

In one embodiment, the chip device 1 shown in FIGS. 1 to 4 constitutes a chip container set 3 by combining with the container 2 shown in FIGS. A tip electrode device 5 is configured by combining with the electrode device 4 shown in FIG. However, the application of the chip device 1 is not limited to being used in combination with the container 2 and the electrode device 4.

As shown in FIGS. 1 to 4, the chip device 1 includes a tubular chip 6 and a base 8 that is connected to the rear end 6a of the chip 6 and includes a base connecting portion 7a as a first connecting portion. ing. The base connecting portion 7a is removably connected to a container connecting portion 7b as a second connecting portion provided in the container 2 that accommodates the chip 6. Further, the base connecting portion 7a is removably connected to a holder connecting portion 7c as a second connecting portion provided on the electrode holder 10. The electrode holder 10 projects a linear electrode 9 introduced into the rear end 6a of the chip 6.

Although the tip 6 is formed as a nanotip whose tip portion 6b has an inner diameter on the order of nanometers, the present invention is not limited thereto. The tip 6b of the tip 6 has an inner diameter of, for example, 100 nm. The tip 6 has a cylindrical shape with the tip 6b centered on the axis O whose diameter gradually decreases toward the tip, but the tip is not limited to this. The chip 6 is made of glass, for example.

The base 8 is made of synthetic resin, for example, and is fixed to the rear end 6a of the chip 6, for example, by appropriate means. Examples of means for fixing include adhesion, frictional engagement, engagement between projections and depressions, welding, and insert molding.

The base 8 has a rectangular cylindrical shape centered on the axis O, but is not limited to this. Although the base 8 is provided so as to protrude further toward the rear end than the rear end 6a of the chip 6, the base 8 is not limited thereto.

The base 8 has a grip portion 11 located between the base connecting portion 7a and the tip 6b of the tip 6 and widened in the radial direction of the tip 6, but the grip portion 11 is not limited thereto.

The base 8 has an access hole 12 communicating with the rear end 6a of the chip 6, but the access hole 12 is not limited thereto. The access hole 12 has a guide surface 13 whose diameter gradually decreases toward the rear end 6a of the tip 6, but the guide surface 13 is not limited thereto. Although the guide surface 13 has a conical shape, it is not limited thereto. Although the leading end of the guide surface 13 coincides with the rear end of the inner circumferential surface 6c of the tip 6, the present invention is not limited thereto.

The base 8 has a grounding portion 14 that maintains the tip end 6b of the chip 6 separated from the planar surface S on which the chip 6 is placed, but the present invention is not limited thereto. Although the grounding portion 14 is located on the outer circumferential surface 8a of the base 8, the present invention is not limited thereto. The base 8 has a quadrangular prism shape having an outer circumferential surface 8a with four planes, and each of these planes can function as the grounding part 14, but the present invention is not limited thereto. Further, the grounding portion 14 is not limited to a planar shape, and may be, for example, a curved shape. The center of gravity of the base 8 is appropriately set so that the tip 6b of the tip 6 is maintained apart from the surface S by grounding the grounding portion 14 on the surface S.

The base connecting portion 7a and the container connecting portion 7b or the holder connecting portion 7c are configured to be connected by engagement between concave and convex portions, but are not limited to this, and may be configured to be connected by engagement by friction, for example. It's okay. The base connecting portion 7a and the container connecting portion 7b or the holder connecting portion 7c are configured to be connected by screwing, but are not limited to this, and are configured to be connected by engagement of unevenness other than screwing. may be done.

As shown in FIGS. 5 to 7, the container 2 has a communication hole 15 that communicates the outside of the container 2 with the rear end portion 6a of the chip 6, but the present invention is not limited thereto. Although the communication hole 15 is provided concentrically with the axis O of the chip 6, the invention is not limited thereto.

Although the container 2 includes a cap 16 having a container connecting portion 7b and a container body 17 including a mouth portion 17a that is removably connected to the cap 16, the present invention is not limited thereto. The container 2 is made of synthetic resin, for example.

The cap 16 includes a cylindrical wall 16a centered on the axis O, and an annular flange 16b extending radially outward from the upper end of the cylindrical wall 16a, but is not limited thereto. The lower end of the inner circumferential surface 16c of the cylindrical wall 16a constitutes a container connecting portion 7b. The remaining portion of the inner peripheral surface 16c of the cylinder wall 16a constitutes the communication hole 15. Although the cylindrical wall 16a is cylindrical, it is not limited to this, and may have a cylindrical shape other than the cylindrical shape. Although the flange 16b is annular, the present invention is not limited to this, and the flange 16b may have an annular shape other than the annular shape.

In this specification, the vertical direction refers to the direction along the axis O, and the upward direction refers to the direction from the tip 6b of the tip 6 to the rear end 6a of the tip 6 (that is, upward in FIGS. 5 and 10). , and downward means the opposite direction.

The outer circumferential surface of the cylinder wall 16a is removably connected to the inner circumferential surface 17b of the mouth portion 17a, but the present invention is not limited thereto. The outer circumferential surface of the cylindrical wall 16a is configured to be connected to the inner circumferential surface 17b of the mouth portion 17a by engagement between projections and recesses, but is not limited to this, and may be configured to be connected by engagement by friction, for example. It's okay. The outer circumferential surface of the cylindrical wall 16a is configured to be connected to the inner circumferential surface 17b of the mouth portion 17a by screwing, but the invention is not limited to this, and the outer circumferential surface of the cylinder wall 16a is configured to be connected by engagement of unevenness other than screwing. may be done.

Although the mouth portion 17a of the container body 17 is cylindrical, it is not limited to this, and may have a cylindrical shape other than the cylindrical shape. A body portion 17c surrounding the chip device 1 is connected to the mouth portion 17a. The body portion 17c has a cylindrical shape with a bottom extending downward from the lower end of the mouth portion 17a, but is not limited thereto. For example, the shape of the body portion 17c is not limited to a cylindrical shape with a bottom. The body portion 17c has a cylindrical shape with a bottom, but is not limited to this, and may have a cylindrical shape with a bottom other than the cylindrical shape with a bottom.

As shown in FIGS. 8 and 9, the chip electrode device 5 includes a chip device 1 and an electrode device 4. As shown in FIGS. The electrode device 4 includes an electrode holder 10 having a holder connection part 7c, and a linear electrode 9 that projects from the electrode holder 10 and is introduced into the rear end 6a of the tip 6. The electrode 9 is made of metal such as silver. The electrode holder 10 is made of synthetic resin, for example.

Although the electrode holder 10 has a concave portion 10a that is concentric with the axis O of the tip 6 and opens downward, the present invention is not limited thereto. Although the electrode 9 protrudes downward from the upper end surface 10b of the recess 10a concentrically with the axis O, the present invention is not limited thereto. Although the holder connecting portion 7c is constituted by the inner peripheral surface 10c of the recessed portion 10a, the present invention is not limited thereto. Although the electrode 9 extends to the tip side of the chip 6 in a state where the base connecting portion 7a and the holder connecting portion 7c are connected, the electrode 9 is not limited thereto. The chip 6 is filled with a liquid L, and the tip 9a of the electrode 9 is immersed in the liquid L. The liquid L is filled in the tip 6b of the chip 6 without any gaps, that is, without any air bubbles. The amount of liquid L and the length of electrode 9 can be changed as appropriate.

Although the recess 10a is formed at the tip 10d of the electrode holder 10, the present invention is not limited thereto. Although the tip portion 10d of the electrode holder 10 has a cylindrical shape, it is not limited thereto, and may have a cylindrical shape other than the cylindrical shape, for example.

In the present embodiment, the chip device 1 is used for purposes such as measurement, injection, and collection of samples such as cells as described below, but is not limited thereto.

First, the chip device 1 is distributed, sold, and stored in a container 2 as shown in FIG. In use, the liquid L is introduced from the rear end 6a of the tip 6 in this state using, for example, a pipette. That is, by inserting a pipette into the rear end 6a of the tip 6 through the communication hole 15 and the access hole 12, the liquid L is introduced into the tip 6. At this time, the pipette can be guided into the rear end 6a of the tip 6 by the guide surface 13 of the access hole 12. Once the liquid L is introduced, the chip container set 3 is placed in a centrifuge.

When the treatment with the centrifuge is finished, the cap 16 of the container 2 is opened and the chip device 1 is removed from the cap 16. As shown in FIG. 4, the removed chip device 1 is placed on the surface S via the grounding part 14, and the tip 6b of the chip 6 is observed with a microscope. At this time, since the tip 6b of the tip 6 is maintained apart from the surface S, contamination of the tip 6b of the tip 6 can be easily suppressed. If the liquid L is not completely filled into the tip 6b, the chip device 1 is attached to the cap 16 again, the cap 16 is closed, and the chip container set 3 is placed in the centrifuge again.

In this way, the chip device 1 can be easily attached to and detached from the container 2 via the base connection part 7a and the container connection part 7b. Further, the chip device 1 can be easily attached to and detached from the container 2 by grasping the grip portion 11 with, for example, a finger.

When it is confirmed through this observation that the tip 6b of the chip 6 is filled with the liquid L without any gaps, the chip device 1 is attached to the electrode device 4 as shown in FIG. That is, the electrode 9 is inserted into the rear end 6a of the chip 6 through the access hole 12, and the chip device 1 is attached to the electrode holder 10 via the base connection part 7a and the holder connection part 7c. At this time, the electrode 9 can be guided into the rear end 6a of the chip 6 by the guide surface 13 of the access hole 12. By dipping the tip 6b of the tip 6 into the sample and applying an electric field between the sample and the electrode 9, the various purposes described above can be achieved.

In this way, the chip device 1 can be easily attached to and detached from the electrode device 4 via the base connection part 7a and the holder connection part 7c. Further, the chip device 1 can be easily attached to and detached from the electrode device 4 by grasping the grip portion 11 with, for example, a finger.

According to the chip device 1 according to the present embodiment, not only can the operation of attaching and detaching the tip 6 to and from the container 2 and the electrode holder 10 be completed quickly, but also damage to the tip due to incorrect operation during attachment and detachment can be avoided, and re-work is therefore required. The occurrence of can be suppressed. Therefore, the efficiency of a series of operations for achieving the various objectives mentioned above can be dramatically improved.

The chip device 1 according to one embodiment described above can also be combined with the container 2 according to another embodiment shown in FIGS. 10 to 11 to configure a chip container set 3 according to another embodiment. Note that in FIGS. 10 and 11, the same reference numerals are given to elements corresponding to those in the embodiment described above.

In this embodiment, the container 2 is configured to form a sealed space 18 in which the chip device 1 is housed. For this purpose, the container 2 further includes a closing cap 19 that releasably closes the communication hole 15 of the cap 16. Although the closure cap 19 is configured to be connected to the communication hole 15 by engagement between projections and recesses, the present invention is not limited thereto, and may be configured to connect by engagement by friction, for example. Although the closure cap 19 is configured to be connected to the communication hole 15 by screwing, the present invention is not limited to this, and may be configured to connect by engagement between projections and recesses other than screwing.

Further, an annular first seal member 20 is further provided between the communication hole 15 and the closure cap 19, but the present invention is not limited thereto. Although the first sealing member 20 is held by the closing cap 19, the first sealing member 20 is not limited to this, and may be held by the cap 16. Furthermore, an annular second seal member 21 is further provided between the cap 16 and the mouth portion 17a, but the present invention is not limited thereto. The second seal member 21 may be held by either the cap 16 or the mouth portion 17a.

The chip container set 3 is distributed, sold, or stored, for example, with the container 2 filled with a desired fluid such as the liquid L, and with the chip device 1 accommodated therein. Further, by removing the closure cap 19 from the cap 16, the chip container set 3 can be used for the same purpose and method as in the embodiment described above, for example.

The chip device 1 according to one embodiment described above can also be combined with the electrode device 4 according to another embodiment shown in FIGS. 12 to 13 to configure a chip electrode device 5 according to another embodiment. Note that in FIGS. 12 and 13, the same reference numerals are given to elements corresponding to those in the embodiment described above.

In this embodiment, the electrode holder 10 includes an electrode terminal 22 as a first terminal connected to the rear end of the electrode 9, and a holder terminal 23 as a second terminal that removably contacts the first terminal. are doing. In this embodiment, the electrode 9 constitutes an electrode device 24 in combination with the electrode terminal 22. Further, in this embodiment, the chip device 1 constitutes a chip electrode set 25 by being combined with the electrode device 24. Note that FIG. 12 shows a state in which the connection between the base connection part 7a and the holder connection part 7c is completed, and the electrode terminal 22 and the holder terminal 23 are in contact with each other. FIG. 13 shows a state in which the base connecting portion 7a and the holder connecting portion 7c are in the process of changing from the connected state to the disconnected state, and the electrode terminal 22 and the holder terminal 23 are disconnected from each other. The electrode terminal 22 and the holder terminal 23 are each made of a metal such as silver.

The electrode device 24 may be distributed, sold, and stored together with the chip device 1 or the chip container set 3 (shown in FIG. 5 or 10, for example), or may be distributed, sold, and stored separately from these.

The electrode terminal 22 includes a contact portion 22a disposed on the rear end surface of the base 8, and a shaft portion 22b connecting the contact portion 22a to the electrode 9, but the present invention is not limited thereto. The contact portion 22a of the electrode terminal 22 has a disk shape centered on the axis O, but is not limited thereto. The shaft portion 22b of the electrode terminal 22 has a cylindrical shape centered on the axis O, but is not limited thereto. Although the rear end of the electrode 9 is connected to the tip of the shaft portion 22b, the present invention is not limited thereto.

The holder terminal 23 has a contact portion 23a disposed on the upper end surface 10b of the recess 10a of the electrode holder 10, and a shaft portion 23b disposed within the recess communication hole 10e communicating with the recess 10a and connected to the contact portion 23a. Yes, but not limited to this. The contact portion 23a of the holder terminal 23 has a disk shape centered on the axis O, but is not limited thereto. The shaft portion 23b of the holder terminal 23 has a cylindrical shape centered on the axis O, but the shape is not limited to this. Although the recess communication hole 10e is formed by a cylindrical inner peripheral surface centered on the axis O, the invention is not limited thereto.

The electrode device 24 is placed on the chip device 1, for example, after the liquid L is introduced into the chip 6 of the chip device 1.

By connecting the base connecting portion 7a to the holder connecting portion 7c with the electrode device 24 disposed on the chip device 1, the contact portion 22a of the electrode terminal 22 and the contact portion 23a of the holder terminal 23 are connected to each other on the base 8. It is sandwiched between the rear end surface (upper end surface) and the upper end surface 10b of the recessed portion 10a, and is in contact with each other. By contacting the electrode terminal 22 and the holder terminal 23 in this manner, it becomes possible to apply an electric field between the sample and the electrode 9.

Further, by separating the base connecting portion 7a from the holder connecting portion 7c, the contact portion 22a of the electrode terminal 22 and the contact portion 23a of the holder terminal 23 can be separated from each other. Therefore, when replacing the chip device 1 held by the electrode holder 10, the electrode device 24 can also be replaced. Therefore, it is possible to prevent the liquid L adhering to the electrode 9 before the chip device 1 is replaced from mixing with the liquid L in the chip device 1 after the chip device 1 is replaced. This effect is particularly noticeable when the chip device 1 before and after replacement holds different types of liquid L from each other.

Note that other procedures when measuring, injecting, collecting, etc. a sample such as a cell using the tip electrode device 5 of this embodiment are the same as in the above-described embodiment.

The embodiment described above is an example of the present disclosure, and it goes without saying that various changes can be made.

1 Chip device 2 Container 3 Chip container set 4 Electrode device 5 Chip electrode device 6 Chip 6a Rear end of chip 6b Tip of chip 6c Inner peripheral surface of chip 7a Base connection part (first connection part)
7b Container connection part (second connection part)
7c Holder connection part (second connection part)
8 Base 8a Outer peripheral surface of the base 9 Electrode 10 Electrode holder 10a Recess 10b Upper end surface of the recess 10c Inner peripheral surface of the recess 10d Tip 10e of the electrode holder Recess communication hole 11 Grip part 12 Access hole 13 Guide surface 14 Grounding part 15 Communication hole 16 Cap 16a Cylinder wall 16b Flange 16c Inner peripheral surface 17 of cylinder wall Container body 17a Mouth 17b Inner peripheral surface of mouth 17c Body 18 Sealed space 19 Closure cap 20 First seal member 21 Second seal member 22 Electrode terminal ( 1st terminal)
22a Contact portion 22b Shaft portion 23 Holder terminal (second terminal)
23a Contact portion 23b Shaft portion 24 Electrode device 25 Chip electrode set O Axial center S Surface L Liquid

Claims (15)

a tubular tip;
a base that continues to the rear end of the chip and includes a first connection portion;
comprising a second connection part removably connected to the first connection part and a container accommodating the chip ;
The base has a grounding part that maintains a tip end of the chip away from a flat surface on which the chip is placed,
The connecting portions are connected to each other by engagement of the concave and convex portions.
Chip container set . a tubular tip;
a base that continues to the rear end of the chip and includes a first connection portion;
an electrode holder comprising a second connection part that is removably connected to the first connection part;
a linear electrode protruding from the electrode holder and introduced into the rear end of the chip ;
The base has a grounding part that maintains a tip end of the chip away from a flat surface on which the chip is placed,
The connecting portions are connected to each other by engagement of the concave and convex portions.
Tip electrode device . The chip container set according to claim 1 , wherein the base has a grip part located between the first connecting part and the tip end of the chip and widened in a radial direction of the chip. The chip container set according to claim 1 or 3 , wherein the base has an access hole communicating with the rear end of the chip. The tip container set according to claim 4, wherein the access hole has a guide surface that gradually reduces in diameter toward the rear end of the tip. The chip container set according to any one of claims 1 and 3 to 5, wherein the grounding portion is located on the outer peripheral surface of the base. The chip container set according to any one of claims 1 and 3 to 6, wherein the connecting portions are connected to each other by screwing. The chip container set according to any one of claims 1 and 3 to 7 , wherein the container has a communication hole that communicates the outside of the container with the rear end portion of the chip. The chip container according to any one of claims 1 and 3 to 8, wherein the container has a cap having the second connection portion and a container body having a mouth portion removably connected to the cap. set. The tip electrode device according to claim 2, wherein the base has a grip portion located between the first connection portion and the tip end portion of the tip and widened in a radial direction of the tip. The tip electrode device according to claim 2 or 10, wherein the base has an access hole communicating with the rear end of the tip. The tip electrode device according to claim 11, wherein the access hole has a guide surface whose diameter gradually decreases toward the rear end of the tip. The tip electrode device according to any one of claims 2 and 10 to 12, wherein the ground portion is located on the outer peripheral surface of the base. The tip electrode device according to any one of claims 2 and 10 to 13, wherein the connecting portions are connected to each other by screwing. a tubular tip;
a base that is continuous with the rear end of the chip and includes a first connection part;
an electrode device comprising a linear electrode introduced into the rear end of the chip and a first terminal connected to the rear end of the electrode;
The first connection part is removably connected to a second connection part provided on the electrode holder,
A tip electrode set in which the first terminal removably contacts a second terminal provided on the electrode holder.

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