JP7362245B2 - Antibacterial and antifungal agents, hard surface cleaning compositions and hard surface cleaning aerosol products - Google Patents

Description

The present invention relates to antibacterial and antifungal agents, hard surface cleaning compositions, and hard surface cleaning aerosol products.

Living environment equipment includes many hard surfaces such as ceramics, plastics, tiles, and metals used for toilet bowls, bathtubs, washstands, walls, etc. Various microorganisms such as bacteria and fungi (mold, etc.) adhere to these hard surfaces. Conventionally, various antibacterial and antifungal agents have been developed to prevent the proliferation of microorganisms that adhere to hard surfaces.

Natural fragrances are sometimes used as active ingredients in antibacterial and antifungal agents. For example, Patent Document 1 discloses that certain terpenes and their derivatives, such as citral, linalool, and tetrahydrolinalool, are used to infect Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Penicillium viridicatom ( It has been shown that it has the ability to inhibit the reproduction of Penicillium viridicatum.

Japanese Unexamined Patent Publication No. 4-021606

If the various agents that have been used as antibacterial and antifungal agents, including terpene compounds, are used alone, a large amount of the agent is required to be sufficiently effective as an antibacterial and antifungal agent, which not only increases cost but also increases the cost. Safety issues such as skin irritation and environmental deterioration arise. Furthermore, a single drug has the problem of being weakly effective against a wide range of microorganisms, although it has the ability to prevent the growth of specific bacteria and molds.

The present invention has excellent antibacterial and antifungal effects against a wide range of microorganisms such as bacteria and fungi, even when used at low concentrations. The aim is to provide a gentle antibacterial and antifungal agent. Another object of the present invention is to provide a hard surface cleaning composition and a hard surface cleaning aerosol product containing the above-mentioned antibacterial and antifungal agent.

In order to solve the above-mentioned problems, the present inventors have conducted intensive research on combinations of various drugs, and as a result, have completed the present invention.

That is, according to one aspect of the present invention, there is provided an antibacterial and antifungal agent containing a monoterpene compound (A) and at least one compound (B) selected from quaternary ammonium salts and phenolic fungicides. be done.

In one form, the antibacterial and antifungal agent contains at least an acyclic monoterpene compound as the monoterpene compound (A).

In one form, the antibacterial and antifungal agent contains at least an acyclic monoterpene having an aldehyde group as the monoterpene compound (A).

In another form, the antibacterial and antifungal agent contains at least citral as the monoterpene compound (A).

In another form, the quaternary ammonium salt is a compound selected from the group consisting of a compound represented by the following general formula (Ia), a compound represented by the following general formula (Ib), and benzalkonium chloride. It is.

In formulas (Ia) and (Ib),
R ₁ , R ₂ and R ₃ each independently represent a straight chain or branched alkyl group having 1 to 16 carbon atoms, and R ₄ represents polyoxyethylene or a straight chain or branched chain having 1 to 16 carbon atoms. represents an alkyl group, Xa ⁻ represents a chloride ion, carboxylate ion or bicarbonate ion, and Xb ²⁻ represents a carbonate ion.

In other forms, the quaternary ammonium salt is a non-chlorinated compound.

In another form, the phenolic fungicide is isopropylmethylphenol.

In another embodiment, the blending ratio of the monoterpene compound (A) and the compound (B) may be 1:10 to 10:1, or 1:5 to 5:1 by mass. Here, when the antibacterial and antifungal agent contains two or more kinds of compounds (B), the compound (B) in the above compounding ratio means the total.

According to another aspect of the present invention, there is provided a hard surface cleaning composition containing the above-mentioned antibacterial and antifungal agent.

In one form, the hard surface cleaning composition further contains a surfactant, a water-soluble solvent, and water.

In another embodiment, the hard surface cleaning composition contains the quaternary ammonium salt as the compound (B) and at least one of a nonionic surfactant and an amphoteric surfactant as the surfactant. .

In another embodiment, the hard surface cleaning composition contains the phenolic disinfectant as the compound (B) and an anionic surfactant as the surfactant.

In other forms, the hard surface cleaning composition further includes a liquefied gas.

In another embodiment, the content of the antibacterial and antifungal agent relative to the total weight of the hard surface cleaning composition may be from 0.01 to 1% by weight, and from 0.1 to 0.8% by weight. good.

According to another aspect of the present invention, there is provided an aerosol product for cleaning hard surfaces, which is obtained by filling a container equipped with an aerosol valve with the hard surface cleaning composition described above.

The present invention has excellent antibacterial and antifungal effects against a wide range of microorganisms such as bacteria and fungi, even when used at low concentrations. It is now possible to provide a gentle antibacterial and antifungal agent, a composition for cleaning hard surfaces, and an aerosol product for cleaning hard surfaces.

1 is a schematic diagram showing the appearance of an aerosol product for cleaning hard surfaces according to an embodiment of the present invention.

Embodiments of the present invention will be described below.
≪Antibacterial and antifungal agent≫
The antibacterial and antifungal agent according to the embodiment of the present invention contains at least one monoterpene compound (A) and at least one compound selected from quaternary ammonium salts and phenolic fungicides as an antibacterial and antifungal component. (B) as an active ingredient.

Here, "containing as an active ingredient" means containing an antibacterial and antifungal component consisting of at least one monoterpene compound (A) and at least one compound (B) to the extent that the desired antibacterial and antifungal performance can be exhibited. The content can be set as appropriate. Therefore, the antibacterial and antifungal agent according to the embodiment may be a composition consisting only of an antibacterial and antifungal component consisting of a monoterpene compound (A) and a compound (B), or may be a composition consisting of only other antibacterial and antifungal components or an antibacterial and antifungal component. The composition may also contain other optional components that do not have antifungal properties.

In one form, the antibacterial and antifungal agent according to the embodiment of the present invention is suitably used for hard surfaces. Examples of hard surfaces include, but are not limited to, surfaces provided on walls, floors, appliances, equipment, etc. in toilets, bathrooms, kitchens, sinks, etc., and hard surfaces include ceramics, plastics, metals, Examples include glass.

In particular, the antibacterial and antifungal agent according to the embodiment of the present invention can exhibit sufficient antibacterial and antifungal effects when the hard surface is a surface to which microorganisms can adhere and grow. Examples include toilet bowls, bathtubs, washstands, etc.

Microorganisms on which the antibacterial and antifungal agent according to the embodiment of the present invention exhibits excellent antibacterial and antifungal effects include a wide range of microorganisms, including fungi, bacteria, and the like. Specifically, the bacteria include Escherichia genus such as Escherichia coli, Methylobacterium genus such as Methylobacterium mesophilicum, and Pseudomonas aeruginosa. s aeruginosa), Pseudomonas genus, Serratia Gram-negative bacteria such as Serratia genus such as S. marcescens, Staphylococcus genus such as Staphylococcus aureus, Bacillus such as Bacillus subtilis, Bacillus cereus, etc. Gram-positive bacteria such as Bacillus and lactic acid bacteria Examples include bacteria.

Specifically, the fungi include Cladosporium genus such as Cladosporium cladosporioides, Penicillium genus such as Penicillium citrinum, and Aspergillus genus Aspergillus. Aspergillus spp. The genus Alternaria such as Alternaria alternata, the genus Fusarium such as Fusarium solani, the genus Eurotium such as Eurotium herbariorum, and the genus Rhodotorula (R red yeasts such as Hodotorula mucilaginosa), Aureoba Examples include black yeasts such as the genus Aureobasidium and the genus Exophiala, the genus Phoma, the genus Candida, and the genus Saccharomyces.

The antibacterial and antifungal agent according to the present embodiment exhibits excellent antibacterial and antifungal effects against all microorganisms that tend to occur in toilet bowls and the like. That is, not only Escherichia coli and Staphylococcus aureus, but also microorganisms that cause black and red stains in toilet bowls, such as the black Cladosporium genus and Exophiala ( It also acts suitably against the genus Exophiala, the red genus Methylobacterium, the genus Rhodotorula (Rhodotorula mucilaginosa), and the like.

The antibacterial and antifungal ingredients will be explained in detail below.
<Monoterpene compound (A)>
The monoterpene compound (A) is a compound having a molecular formula of C ₁₀ H ₁₆ consisting of two isoprene units, and may be a derivative thereof. Furthermore, when stereoisomers exist, the compound may be in the form of any one of the stereoisomers or in the form of a mixture thereof.

The monoterpene compound (A) may be an acyclic monoterpene, a monocyclic monoterpene, or a polycyclic monoterpene.

Acyclic monoterpenes include citral, citronellal, ocimene, myrcene, geraniol, β-citronellol, linalool, nerol, myrcenol, dihydromircenol, lavandulol, linalyl formate, geranyl formate, citronellyl formate, linalyl acetate, and acetic acid. Geranyl, citronellyl acetate, neryl acetate, lavandulyl acetate, ocimenyl acetate, myrcenyl acetate, linalyl propionate, geranyl propionate, citronellyl propionate, linalyl butyrate, geranyl butyrate, citronellyl butyrate, linalyl isobutyrate, geranyl isobutyrate, citronellyl isobutyrate, Examples include linalyl benzoate and geranyl benzoate.

Examples of monocyclic monoterpenes include limonene, phellandrene, terpinolene, terpinene, and menthane.

Examples of the multicyclic monoterpene include carene, thujene, and pinene.

In one form, the antibacterial and antifungal agent preferably contains an acyclic monoterpene as the monoterpene compound (A), and more preferably contains at least an acyclic monoterpene having an aldehyde group such as citral or citronellal. Preferably, it preferably contains at least citral. Citral has trans/cis isomers; the trans isomer is called α-citral (geranial), and the cis isomer is called β-citral (neral), but both are effective, and a mixture of α- and β- It may be.

<Compound (B)>
The quaternary ammonium salt as compound (B) is not particularly limited. For example, the quaternary ammonium salt is a compound selected from the group consisting of a compound represented by the following general formula (Ia), a compound represented by the following general formula (Ib), and benzalkonium chloride. be.

In formulas (Ia) and (Ib),
R ₁ , R ₂ and R ₃ each independently represent a straight chain or branched alkyl group having 1 to 16 carbon atoms, and R ₄ represents polyoxyethylene or a straight chain or branched chain having 1 to 16 carbon atoms. represents an alkyl group, Xa ⁻ represents a chloride ion, carboxylate ion or bicarbonate ion, and Xb ²⁻ represents a carbonate ion.

In one form of the quaternary ammonium salt represented by general formula (Ia) or (Ib), R ₁ and R ₂ are linear or branched alkyl groups having 8 to 10 carbon atoms, and R ₃ and R ₄ is preferably a compound having a cation moiety that is a methyl group. In another form, in the quaternary ammonium salt represented by the general formula (Ia) or (Ib), R ₁ and R ₂ are linear or branched alkyl groups having 8 to 10 carbon atoms, and R It is preferable that ₃ is a methyl group and R ₄ is a compound having a cation moiety that is polyoxyethylene.

Such quaternary ammonium salts represented by general formula (Ia) or (Ib) are available from Lonza Japan Co., Ltd. under the trade names Bardap (registered trademark) 26, Carboquat (registered trademark) MW50, and Bardac (registered trademark). Trademark) LF-80, Bardac 2250, Bardac 2280, Bardac 205M.

Examples of the carboxylic acid ion represented by Xa ⁻ include acetate ion, propionate ion, and the like.

In one form, the quaternary ammonium salt may be a non-chlorinated compound. Examples of such quaternary ammonium salts include compounds in which Xa ^- in general formula (Ia) is a carboxylic acid ion or bicarbonate ion, or compounds represented by general formula (Ib).

The phenolic fungicide used as compound (B) is not particularly limited. For example, the phenolic fungicide may be isopropylmethylphenol (IPMP), thymol, parachlorometacresol, resorcinol, hinokitiol, hexachlorophene, triclosan, etc., and one or more of these may be used. Can be used. In one form, the phenolic fungicide is preferably IPMP, thymol or triclosan, more preferably IPMP. As IPMP, any of 3-methyl-4-isopropylphenol (Biozol), 2-isopropyl-5-methylphenol (thymol), and 2-methyl-5-isopropylphenol (carvacrol) can be used, Among them, 3-methyl-4-isopropylphenol (Biosol) is preferred.

The blending ratio of the monoterpene compound (A) and the compound (B) is appropriately selected depending on the type of hard surface to be treated, the type of industrial product, the conditions for applying the antibacterial and antifungal agent, etc. In one form, the blending ratio of the monoterpene compound (A) and the compound (B) may be 1:10 to 10:1, and may be 1:5 to 5:1 in mass ratio.

The antibacterial and antifungal agent according to the embodiment of the present invention can be used in various forms depending on its purpose and use. For example, it may be mixed with known additives such as surfactants, thickeners, solvents, fragrances, and other fungicides to the extent that their excellent effects are not impaired. In one form, the antibacterial and antifungal agent according to an embodiment of the present invention is suitably used as a hard surface cleaning composition described below.

≪Hard surface cleaning compositions and hard surface cleaning aerosol products≫
The hard surface cleaning composition according to an embodiment of the present invention contains the above-mentioned antibacterial and antifungal agent. When used on hard surfaces, it exhibits excellent microbial control effects. As mentioned above, the hard surfaces to be used are ceramic, plastic, metal, glass, etc. surfaces provided on walls, floors, appliances, equipment, etc. of toilets, bathrooms, kitchens, wash basins, etc. To give one example, the hard surface cleaning composition according to the embodiment of the present invention is suitably used for toilet bowls, bathtubs, washbasins, etc. where microorganisms tend to adhere and multiply.

In the hard surface cleaning composition according to the embodiment of the present invention, the blending ratio of the above-mentioned antibacterial and antifungal agent can be appropriately selected depending on conditions such as the type of target hard surface and the type of industrial product. In one form, the blending ratio of the antibacterial and antifungal agent in the hard surface cleaning composition may be 0.01 to 1% by mass, and 0.1 to 1% by mass, based on the total mass of the hard surface cleaning composition. It may be 0.8% by mass. Even at such a low concentration of the antibacterial and antifungal agent, the hard surface cleaning composition according to the embodiment of the present invention has excellent antibacterial and antifungal effects against a wide range of microorganisms such as bacteria and fungi. In addition, as a result of using low concentrations, it is gentle on the human body and the environment.

The hard surface cleaning composition according to the embodiment of the present invention may contain other ingredients, such as surfactants, water-soluble solvents, thickeners, and water, to the extent that the effects of the above-mentioned antibacterial and antifungal agents are not inhibited. It can contain arbitrary ingredients.

The surfactant that may be contained in the hard surface cleaning composition according to the embodiment is not particularly limited, and includes nonionic surfactants, anionic surfactants, amphoteric surfactants, and silicone surfactants. Agents, natural surfactants, amino acid surfactants, etc. can be appropriately selected and used. In one form, any surfactant that can be used in an aqueous composition may be used. In addition, when provided as an aerosol product as described below, it can be appropriately selected from the viewpoint of foam forming properties.

Specific examples of surfactants include polyoxyethylene (hereinafter referred to as "POE") cetyl ether, POE stearyl ether, POE oleyl ether, POE lauryl ether, POE behenyl ether, POE octyl dodecyl ether, and POE isocetyl ether. , polyoxyethylene alkyl ethers such as POE isostearyl ether; polyoxyethylene sorbitan fatty acid esters such as monococonut oil fatty acid POE sorbitan, monostearate POE sorbitan, monooleate POE sorbitan; POE/POP cetyl ether, POE/POP decyl tetra Polyoxyethylene polyoxypropylene alkyl ethers such as decyl ether; polyoxyethylene glycerin fatty acid esters such as POE glyceryl monostearate; polyoxyethylene lanolin alcohols such as POE lanolin alcohol; polyoxyethylene hydrogenated castor oil such as POE hydrogenated castor oil ; Polyethylene glycol fatty acid esters such as polyethylene glycol monostearate, hexaglyceryl monolaurate, hexaglyceryl monomyristate, pentaglyceryl monolaurate, pentaglyceryl monomyristate, pentaglyceryl monooleate, pentaglyceryl monostearate, decaglyceryl monolaurate , polyglycerin fatty acid esters such as decaglyceryl monomyristate, decaglyceryl monostearate, decaglyceryl monoisostearate, decaglyceryl monooleate, decaglyceryl monolinoleate; polyoxyethylene glycerin fatty acid esters such as POE glyceryl monooleate ; Polyoxyethylene sorbitan fatty acid esters such as POE sorbitan monopalmitate, POE sorbitan monostearate, POE sorbitan monoisostearate, POE sorbitan monooleate; POE sorbitan monolaurate, POE sorbitan tetrastearate, POE sorbitan tetraoleate, etc. Examples include nonionic surfactants such as polyoxyethylene sorbitol fatty acid ester;

Also included are fatty acid soaps; alkyl sulfates; anionic surfactants such as polyoxyalkylene alkyl ether sulfates such as sodium polyoxyethylene lauryl ether sulfate, alkyl phosphates, and polyoxyethylene alkyl ether phosphates.

Further examples include amine oxides such as alkyldimethylamine oxide, sulfobetaines such as alkyldimethylsulfobetaine, and amphoteric surfactants such as carbobetaines.

In addition, silicone surfactants such as polyoxyethylene/methylpolysiloxane copolymer, polyoxypropylene/methylpolysiloxane copolymer, poly(oxyethylene/oxypropylene)/methylpolysiloxane copolymer, and surfactin Natural surfactants such as sodium, cyclodextrin, hydrogenated soybean lecithin, N-coconut oil fatty acid acyl-L-glutamic acid triethanolamine, N-coconut oil fatty acid acyl-L-glutamate potassium, N-coconut oil fatty acid Sodium acyl-L-glutamate, N-lauroyl-L-glutamate triethanolamine, Potassium N-lauroyl-L-glutamate, Sodium N-lauroyl-L-glutamate, Potassium N-myristoyl-L-glutamate, N-Myristoyl-L - N-acylglutamates such as sodium glutamate and sodium N-stearoyl-L-glutamate, N- such as N-coco fatty acid acyl-L-glutamic acid, N-lauroyl-L-glutamic acid, N-stearoyl-L-glutamic acid N-acylglycine salts such as acylglutamic acid, N-coconut oil fatty acid acylglycine potassium, N-coconut oil fatty acid acylglycine sodium, N-acylalanine salts such as N-coconut oil fatty acid acyl-DL-alanine triethanolamine, etc. Examples include amino acid surfactants.
These surfactants can be used alone or in combination of two or more.

In one form of the present invention, when the hard surface cleaning composition according to the embodiment contains a quaternary ammonium salt as the compound (B), the surfactant is selected from nonionic surfactants and amphoteric surfactants. It is preferable to use at least one type. By using a quaternary ammonium salt and a nonionic surfactant or an amphoteric surfactant in combination, mixed micelles are formed, making it possible to improve the detergency against microorganisms.

Moreover, in another form of the present invention, when the hard surface cleaning composition according to the embodiment contains a phenolic disinfectant as the compound (B), it is preferable to use an anionic surfactant as the surfactant. . By using a phenolic disinfectant and an anionic surfactant in combination, it is possible to improve the detergency against microorganisms.

When the hard surface cleaning composition according to the embodiment contains a surfactant, the blending ratio of the surfactant is not particularly limited, but for example, 0.1 to 10% by mass based on the total mass of the composition. The amount may be 0.5 to 5% by weight. It is preferable to suppress the blending ratio of the surfactant from the viewpoint of foam removal and rinsability.

The water-soluble solvent that can be contained in the hard surface cleaning composition according to the embodiment is not particularly limited. When provided as an aerosol product as described below, it is preferable that the foam forming property (foaming property) can be adjusted. Specific examples of water-soluble solvents include monohydric alcohols having 2 or 3 carbon atoms such as ethanol and isopropanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, hexylene glycol, diethylene glycol, dipropylene glycol, glycerin, etc. Examples include di- to trivalent polyols. These can be used alone or in combination of two or more, but it is preferable to use ethanol from the viewpoint of ease of adjusting the foam forming property.

When the hard surface cleaning composition according to the embodiment contains a water-soluble solvent, the blending ratio of the water-soluble solvent is not particularly limited, but is, for example, 1 to 20% by mass based on the total mass of the composition. It may well be between 5 and 15% by weight.

The thickener that can be contained in the hard surface cleaning composition according to the embodiment is not particularly limited. When provided as an aerosol product as described below, it is preferable that the persistence (retention ability) of the foam can be adjusted. Specific examples of thickeners include gums such as xanthan gum, carrageenan, gum arabic, gum tragacanth, cationized guar gum, guar gum, gellan gum, and locust bean gum; hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, Cellulose polymers such as nitrocellulose and crystalline cellulose; dextran, sodium carboxymethyl dextran, dextrin, pectin, starch, corn starch, wheat starch, sodium alginate, modified potato starch, sodium hyaluronate, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl Examples include polymers. These can be used alone or in combination of two or more, but from the viewpoint of excellent foam retention, it is preferable to use hydroxyethyl cellulose.

When the hard surface cleaning composition according to the embodiment contains a thickener, the blending ratio of the thickener is not particularly limited, but for example, 0.01 to 5% by mass based on the total mass of the composition. The amount may be 0.1 to 1% by weight.

The hard surface cleaning composition according to the embodiment contains water as a base ingredient in one form. When the hard surface cleaning composition according to the embodiment contains water, the blending ratio of water is not particularly limited, but may be, for example, 70 to 99% by mass, 80 to 99% by mass, based on the total mass of the composition. It may be 95% by mass.

Hard surface cleaning compositions according to embodiments may further contain a liquefied gas when provided as an aerosol product filled into a container with an aerosol valve. Here, aerosol products refer to products in which the contents are released by themselves in the form of mist or foam through a valve and out of the container by vaporizing liquefied gas. Examples include aerosol valves. In the following, the hard surface cleaning composition containing liquefied gas is also referred to as "aerosol composition", and in contrast to "liquefied gas", components other than liquefied gas contained in the aerosol composition are referred to as "undiluted solution" or "aqueous undiluted solution". Also called.

FIG. 1 is a schematic diagram showing the appearance of a hard surface cleaning aerosol product (inverted aerosol product) 1 according to an embodiment of the present invention, and includes a pressure-resistant container 2, an inverted aerosol valve 3, and an injection member 4. The pressure container 2 is made of metal such as tin or stainless steel. The aerosol product 1 can be manufactured by filling a pressure-resistant container 2 with an aqueous stock solution, fixing an inverted aerosol valve 3, and then filling the container with liquefied gas. Preferably, the aerosol product for cleaning hard surfaces is constructed with a spout for foaming the concentrate. When the inverted aerosol valve 3 is opened and the aerosol composition is injected, the injected contents become fine mist or foam due to rapid expansion of the liquefied gas.

The liquefied gas used in the aerosol composition according to the embodiment is not particularly limited as long as it is a liquid in the aerosol container and can vaporize when injected to the outside to foam the aqueous stock solution and form bubbles. Examples of such liquefied gases include liquefied petroleum gases such as propane, normal butane, isobutane, and mixtures thereof, trans-1,3,3,3-tetrafluoroprop-1-ene (HFO-1234ze), trans- Examples include hydrofluoroolefins such as -2,3,3,3-tetrafluoroprop-1-ene (HFO-1234yf), dimethyl ether, and mixtures thereof. Further, normal pentane or isopentane may be blended with the liquefied gas.

The vapor pressure (20° C.) of the liquefied gas is preferably 0.20 to 0.55 MPa, more preferably 0.30 to 0.45 MPa. Note that this vapor pressure is a value measured by a static method. If the vapor pressure is lower than 0.2 MPa, bubble formation will be poor, and if it is higher than 0.55 MPa, it may be difficult to adhere to the object and may scatter and be easily inhaled by the user. be. In addition, when the components and blending amounts used in the aqueous stock solution are the same, when the vapor pressure (20 ° C.) of the liquefied gas is 0.30 to 0.35 MPa, the effect of improving foam formation at low temperatures is obtained. At 0.36 to 0.45 MPa, the effect of excellent foam persistence at low temperatures can be obtained, so the vapor pressure of the liquefied gas may be appropriately selected according to the properties of the intended product.

In this specification, "good foam formation" means that the volume of the foam is large, and "excellent foam persistence" means that the foam that has been formed is maintained and remains without disappearing immediately. means.

The blending ratio of liquefied gas in the aerosol composition in the embodiment of the present invention is not particularly limited, and may be, for example, 3 to 40% by mass, or 5 to 35% by mass. If the blending ratio of liquefied gas is less than 3%, it may be difficult to foam, and if it is more than 40%, it may scatter more, making it difficult to adhere to objects and making it easier for users to inhale.

The method of using the aerosol product according to the embodiment of the present invention described above is not particularly limited, but for example, after spraying an appropriate amount onto the hard surface, leaving it for several minutes until the bubbles disappear, and then washing it off with water etc. good.

In addition to the above-mentioned components, the hard surface cleaning composition according to the embodiment of the present invention may contain known additives, such as other surfactants, bactericides, and disinfectants, depending on the intended use, application, etc. , pH adjusters, ultraviolet absorbers, ultraviolet dispersants, pigments, preservatives, antioxidants, chelating agents, drugs, fragrances, and other components can be combined. The blending ratio of other components is not particularly limited, but is, for example, 0.01 to 1.0% by mass based on the total mass of the hard surface cleaning composition according to the embodiment.

EXAMPLES Hereinafter, the present invention will be explained in more detail with reference to Examples and Comparative Examples, but the present invention is not limited by the Examples and Comparative Examples.

<Preparation of hard surface cleaning composition>
Various compositions were prepared by mixing the components shown in Table 1 below at the blending ratios (% by mass) shown in the same table. In Table 1, antibacterial fragrances 1 and 2 and bactericidal agents 1 to 6 are as follows.

- Antibacterial fragrance 1: A herb-based mixed fragrance containing 10% by mass of citral.
- Antibacterial fragrance 2: A citrus-based mixed fragrance containing 40% by mass of citral.

・Fungicide 1: N,N-didecyl-N-methylpoly(oxyethyl)ammonium propionate (Bardap (registered trademark) 26, Lonza Japan Co., Ltd.)

- Disinfectant 2: N,N-didecyl-N,N-dimethylammonium carbonate/bicarbonate (Carboquat (registered trademark) MW50, Lonza Japan Co., Ltd.)

・Fungicide 3: N,N-dioctyl N,N-dimethylammonium chloride (Bardac (registered trademark) LF-80, Lonza Japan Co., Ltd.)

- Disinfectant 4: N,N-didecyl-N,N-dimethylammonium chloride mixture (Bardac (registered trademark) 205M, Lonza Japan Co., Ltd.) / benzalkonium chloride (Catiogen (registered trademark) BC-50, Daiichi Kogyo) Pharmaceutical Co., Ltd.)

・Bactericide 5: Benzalkonium chloride (Catiogen (registered trademark) BC-50, Daiichi Kogyo Seiyaku Co., Ltd.)

・Fungicide 6: Isopropylmethylphenol (3-methyl-4-isopropylphenol)

<Evaluation method>
[Test 1]
The test was conducted in the following manner using Escherichia coli (NBRC3972) and Staphylococcus aureus (NBRC12732) as test bacteria.

(a) Preparation of test bacteria solution After culturing each of the above test bacteria, suspend and disperse it in 1/2 nutrient liquid medium, and add 1/2 so that the bacterial concentration is 1 to 9 x 10 ⁸ cfu/mL. It was prepared using a nutrient liquid medium and mixed in an equal amount with a 3% by mass bovine serum albumin aqueous solution to obtain a test bacterial solution.

(b) Inoculation of test bacteria solution Place a sterilized stainless steel disk with a diameter of 20 mm, thickness of 1 mm, and surface grade 2B in a glass petri dish, and apply 0.01 mL of the above test bacteria solution onto the disk surface using a micropipette. It was inoculated and spread. After leaving the glass Petri dish uncovered at 25°C and confirming that the test bacterial solution has dried, immediately pipette 0.1 mL of the sample (various compositions prepared according to Table 1) into a 20 mm diameter tube with a micropipette. The inoculation was applied to 3.14 cm ² of the surface of a stainless steel disk and spread to adhere. After 5 minutes of adhesion, the adhered composition was poured into a certain amount of LP water diluent, being careful not to run off, to inactivate the bactericidal performance of the composition.

(c) Cultivation of test bacteria The bacterial suspension in the LP water dilution solution was cultured at 37°C for 24 hours by the pour culture method. Colonies formed after culturing were counted and the number of viable bacteria was calculated. Let the obtained value be _Y1 . In addition, a similar test was performed using a 0.05 mass% polyoxyethylene sorbitan monooleate aqueous solution instead of the above sample as a control, and the colonies formed after culturing were counted in the same manner and the number of viable bacteria was calculated. did. Let the obtained value be _X1 . The sterilization activity value was quantified using the following formula and used as an index of sterilization performance according to the following criteria. The evaluation results are shown in Table 1.

<Bacterial activity value calculation formula>
Bactericidal activity value = logX ₁ - logY ₁

<Evaluation criteria>
A: The sterilizing activity value is 5 or more. B: The sterilizing activity value is 2 or more and less than 5. C: The sterilizing activity value is less than 2.

[Test 2]
The test mold was Cladosporium sp., an environmentally isolated mold. , Exophiala sp. , Methylobacterium sp., an environmental isolate, was used as a test bacterium. The test was conducted using the following method.

(a) Preparation of test mold solution and test fungus solution The above test fungus was cultured on potato dextrose agar medium and the above test fungus was cultured on ^R2A medium. was adjusted to have a bacterial count of 1 to 9×10 ⁸ cfu/mL using a 0.05% by mass polyoxyethylene sorbitan monooleate aqueous solution to prepare a test mold solution and a test fungus solution.

(b) Sample Preparation Using sterile water, various compositions prepared according to Table 1 were adjusted to have a concentration of 50% by mass, and samples were prepared.

(c) Inoculation of test mold solution and test fungus solution 9 mL of each prepared sample was placed in a test tube, and 1 mL each of the test fungus solution and test fungus solution were inoculated thereto, and immediately stirred using a vortex mixer. Ten minutes after the end of stirring, 1 ml of this liquid was added to 9 ml of LP liquid medium to inactivate it.

(d) Cultivation of test molds and test bacteria The molds were cultured at 25°C for 4 days, and the bacteria were cultured at 37°C for 24 hours using the LP liquid medium solution using the pour culture method. Colonies formed after culturing were counted, and the number of spores and viable bacteria were calculated. Let the obtained value be _Y2 .

In addition, a similar test was performed using physiological saline instead of the above sample as a control, and the colonies formed after culturing were counted in the same manner, and the number of spores and the number of viable bacteria were calculated. Let the obtained value be _X2 . The bactericidal activity value was quantified using the following formula and was used as an index of fungicidal and bactericidal performance according to the following criteria. The evaluation results are shown in Table 1.

<Bacterial activity value calculation formula>
Bactericidal activity value = logX ₂ - logY ₂

<Evaluation criteria>
[Mold]
A: Bactericidal activity value is 4 or more B: Bactericidal activity value is 2 or more and less than 4 C: Bactericidal activity value is less than 2 [Bacteria]
A: The sterilizing activity value is 5 or more. B: The sterilizing activity value is 2 or more and less than 5. C: The sterilizing activity value is less than 2.

*Antibacterial fragrance 1: Herbal blended fragrance, containing 10% by mass of citral.
*Antibacterial fragrance 2: Citrus-based mixed fragrance, containing 40% by mass of citral.
*Fungicide 1: N,N-didecyl-N-methylpoly(oxyethylene)ammonium propionate (Bardap26; Lonza Japan Co., Ltd.)
*Bactericide 2: N,N-didecyl-N,N-dimethylammonium carbonate/bicarbonate (Carboquat MW50; Lonza Corporation)
*Fungicide 3: Dioctyldimethylaminium chloride (Bardac LF80; Lonza Japan Co., Ltd.)
*Bactericide 4: N,N-didecyl-N,N-dimethylammonium chloride (Bardac 205M, Lonza Japan Co., Ltd.)/benzalkonium chloride (Cationogen BC-50; Daiichi Kogyo Seiyaku Co., Ltd.) mixture *Bactericide 5 : Benzalkonium chloride (Cationogen BC-50; Daiichi Kogyo Seiyaku Co., Ltd.)
*Fungicide 6: IPMP (3-methyl-4-isopropylphenol (Biosol (registered trademark): Osaka Kasei Co., Ltd.))
*Polyoxyalkylene alkyl ether (Emulgen (registered trademark) LS110; Kao Corporation)
*POE sodium lauryl ether sulfate (Alscope (registered trademark) NS-230; Toho Chemical Industry Co., Ltd.).

From the evaluation results in Table 1, it is clear that the composition containing the antibacterial and antifungal agent according to the embodiment of the present invention has excellent antibacterial and antifungal effects against a wide range of microorganisms even at low concentrations of the antibacterial and antifungal agent. It turns out that it has.

Note that the present invention is not limited to the above-described embodiments, and can be variously modified at the implementation stage without departing from the gist thereof. Moreover, each embodiment may be implemented in combination as appropriate, and in that case, the combined effect can be obtained. Furthermore, the embodiments described above include various inventions, and various inventions can be extracted by combinations selected from the plurality of constituent features disclosed. For example, if a problem can be solved and an effect can be obtained even if some constituent features are deleted from all the constituent features shown in the embodiment, the configuration from which these constituent features are deleted can be extracted as an invention.

1 Aerosol product 2 Pressure-resistant container 3 Inverted aerosol valve 4 Injection member

Claims (14)

An antibacterial and antifungal agent containing at least one monoterpene compound (A) and at least one compound (B) selected from quaternary ammonium salts, wherein the compound (B) is An antibacterial and antifungal agent containing at least one quaternary ammonium salt selected from a compound represented by formula (Ia) and a compound represented by general formula (Ib) below.
In formulas (Ia) and (Ib),
R ₁ , R ₂ and R ₃ each independently represent a straight chain or branched alkyl group having 1 to 16 carbon atoms, and R ₄ represents polyoxyethylene or a straight chain or branched chain having 1 to 16 carbon atoms. represents an alkyl group, Xa ⁻ represents a carboxylate ion or bicarbonate ion, and Xb ²⁻ represents a carbonate ion. An antibacterial and antifungal agent containing at least one monoterpene compound (A) and at least one compound (B) selected from quaternary ammonium salts, wherein the compound (B) is An antibacterial and antifungal agent containing at least one quaternary ammonium salt selected from a compound represented by formula (Ia) and a compound represented by general formula (Ib) below.
In formulas (Ia) and (Ib),
R ₁ , R ₂ and R ₃ each independently represent a straight chain or branched alkyl group having 1 to 16 carbon atoms, R _4a represents polyoxyethylene, and R _4b represents polyoxyethylene or carbon It represents a linear or branched alkyl group of numbers 1 to 16, Xa ^- represents a chloride ion, carboxylate ion or bicarbonate ion, and Xb ^2- represents a carbonate ion. An antibacterial and antifungal agent containing at least one monoterpene compound (A) and at least one compound (B) selected from quaternary ammonium salts, wherein the compound (B) is An antibacterial and antifungal agent containing benzalkonium and at least one quaternary ammonium salt selected from a compound represented by formula (Ia) and a compound represented by general formula (Ib) below.
In formulas (Ia) and (Ib),
R ₁ , R ₂ and R ₃ each independently represent a straight chain or branched alkyl group having 1 to 16 carbon atoms, and R ₄ represents polyoxyethylene or a straight chain or branched chain having 1 to 16 carbon atoms. represents an alkyl group, Xa ⁻ represents a carboxylate ion or bicarbonate ion, and Xb ²⁻ represents a carbonate ion. The antibacterial and antifungal agent according to claim 2 , further comprising benzalkonium as the compound (B). The antibacterial and antifungal agent according to claim 2 or 3, wherein the quaternary ammonium salt is a non-chlorine compound. The antibacterial and antifungal agent according to any one of claims 1 to 5, which contains at least an acyclic monoterpene compound as the monoterpene compound (A). The antibacterial and antifungal agent according to any one of claims 1 to 6, which contains at least citral as the monoterpene compound (A). The antibacterial and antifungal agent according to any one of claims 1 to 7, wherein the monoterpene compound (A) and the compound (B) are mixed in a mass ratio of 1:10 to 10:1. A hard surface cleaning composition containing the antibacterial and antifungal agent according to any one of claims 1 to 8. 10. The hard surface cleaning composition of claim 9, further comprising a surfactant, a water-soluble solvent, and water. The hard surface cleaning composition according to claim 10, comprising the quaternary ammonium salt as the compound (B) and at least one of a nonionic surfactant and an amphoteric surfactant as the surfactant. The hard surface cleaning composition according to any one of claims 9 to 11, further comprising a liquefied gas. The hard surface cleaning composition according to any one of claims 9 to 12, wherein the blending ratio of the antibacterial and antifungal agent is 0.01 to 1% by mass based on the total mass of the hard surface cleaning composition. thing. An aerosol product for cleaning hard surfaces, which is obtained by filling a container equipped with an aerosol valve with the composition for cleaning hard surfaces according to any one of claims 9 to 13.