JP7275747B2 - Chemical liquid delivery device and chemical liquid delivery method - Google Patents

Description

TECHNICAL FIELD The present invention relates to a chemical solution delivery device for delivering a fixed amount of a chemical solution from a container filled with the chemical solution to another container.

Conventionally, when subdividing only the amount required for the time being from a soft packaging container filled with a chemical solution and transferring it to another container, manually using a syringe or using a syringe pump etc. It is widely practiced to transfer this to another container. Syringes have a simple structure and can easily aspirate, inject, and dispense a fixed amount of liquid medicine by sliding a piston with a gasket made of rubber or the like at the tip inside a cylindrical cylinder. can. In addition, in order to maintain the airtightness of the gasket and the cylinder and to improve the slidability of the piston, the inner surface of the cylinder is often coated with silicone oil or a fluorine-based compound. However, when the chemical liquid is sucked, the silicone oil or the like applied to the inner surface of the cylinder may be eluted into the chemical liquid, resulting in deterioration of the chemical liquid.

On the other hand, for example, Patent Document 1 discloses a syringe in which good slidability can be obtained without applying silicone oil to the inner surface of the cylinder by covering the tip of the gasket and the sliding surface with a PTFE film. Gaskets for In Patent Document 2, a cylinder (outer cylinder) is provided with an inner cylinder that can be compressed into a bellows shape, the inner cylinder is filled with a chemical solution, and the inner cylinder is compressed by a plunger. A chemical injection system for injecting and discharging a chemical liquid is described.

JP-A-2005-27831 WO2011/125133

Both Patent Literatures 1 and 2 assume a prefilled syringe filled with a fixed amount of liquid medicine in advance, and do not mention the problem of repeatedly aspirating, injecting, and discharging the liquid medicine. In the method of covering the tip of the gasket and the sliding surface with a slidable film, there is a risk that the film will generate dust and dissolve into the chemical solution after repeated use. In addition, in the method of injecting and discharging the chemical solution by compressing the inner cylinder into a bellows shape, it is unclear whether a certain amount of the chemical solution can be sucked again in a short time after the chemical solution is injected and discharged. In any case, there is a need for a liquid chemical feeding device capable of repeatedly feeding a fixed amount of liquid chemical while suppressing deterioration of the liquid chemical due to elution of silicone oil, film components, and the like.

The present disclosure has been made in view of this situation, and while suppressing the elution of foreign substances such as silicone oil into the chemical solution, a certain amount of the chemical solution is repeatedly poured into another container from a container filled with the chemical solution. It is an object of the present invention to provide a medical solution delivery device capable of transferring, and to provide a method of delivering a medical solution using the medical solution delivery device.

The chemical liquid delivery device according to the present embodiment includes a cylinder having a nozzle portion with a hole at one end and an opening at the other end, and a gasket at the tip, along the inner surface of the cylinder through the gasket. and a piston that can be slid on a liquid medicine delivery device, wherein either the cylinder or the piston regulates the sliding range of the piston from the opening toward the nozzle. A regulation part is formed.

Further, in the drug solution delivery device according to another aspect of the present embodiment, the position of the piston closest to the one end in the sliding range is the first position, and the position of the piston farthest from the one end is the second position. , the internal volume of the cylinder from the one end to the end face of the gasket of the piston at the second position is equal to the end face of the gasket of the piston from the one end at the first position It may be less than twice the volume of the interior of the cylinder up to .

A chemical liquid delivery device according to another embodiment of the present invention includes a first liquid delivery section having a first cylinder having a nozzle section with a hole at one end and a first connection section with a hole at the other end; A second cylinder having a second connection part with a hole in the second cylinder and an opening at the other end, and a gasket at the tip of the second cylinder, which can be slid along the inner surface of the second cylinder through the gasket. and a connecting pipe that connects the first connecting portion of the first liquid feeding portion and the second connecting portion of the second liquid feeding portion, the second A regulating portion that regulates a sliding range of the piston from the opening toward the second connecting portion is formed in either the two cylinders or the piston.

Furthermore, a chemical liquid delivery device according to another aspect of the present embodiment includes a first liquid delivery section having a first cylinder having a nozzle section with a hole at one end and a first connection section with a hole at the other end , a second cylinder having a second connecting part with a hole at one end and an opening at the other end, and a gasket at the tip, along the inner surface of the second cylinder through the gasket. a second liquid feeding section having a piston capable of sliding in a range; and connecting the first connecting section of the first liquid feeding section and the second connecting section of the second liquid feeding section. a connecting pipe, wherein the connecting pipe has a predetermined pressure when the piston of the second liquid feeding section is slid to transfer the gas inside the second liquid feeding section to the first liquid feeding section A filter is provided to remove foreign matter.

Further, in the drug solution delivery device according to another aspect of the present embodiment, the position of the piston closest to the second connection part side in the sliding range is defined as a third position, and the position closest to the second connection part side When the position of the far piston is a fourth position, the first cylinder, the connecting pipe, and The internal volume of the second cylinder is defined by the first cylinder, the connecting pipe, and the second less than twice the internal volume of the cylinder.

A chemical liquid feeding method according to another embodiment of the present invention is a chemical liquid feeding method in which a predetermined amount of a chemical liquid is fed from a first container containing a chemical liquid to a second channel different from the first container. A chemical solution delivery device preparing step of preparing the chemical solution delivery device, connecting a first container containing the chemical solution and the liquid delivery device with a delivery pipe through a channel switching portion, either a first channel capable of transferring a chemical solution only between a container and the liquid-sending device, or a second channel capable of transferring a chemical solution only between the liquid-sending device Selectable distribution pipe connection step, wherein the position of the piston closest to the second connection part side in the sliding range is set as the third position, and the position of the piston farthest from the second connection part side is set to the third position. When the position is set to the fourth position, the first flow path is selected, and the piston of the liquid delivery device is moved from a predetermined position between the third position and the fourth position to the fourth position. By sliding a predetermined distance toward the position of the first container, a predetermined amount of the chemical solution is sent toward the first liquid sending part of the chemical solution sending device through the delivery pipe connected to the lower end of the first container. After the first liquid feeding step and the first liquid feeding step, the arrangement of the first container is changed so that the liquid level of the chemical liquid in the first container is lowered, and the first liquid feeding section A second liquid feeding step of returning the surplus chemical liquid fed to the first container to the first container, and after the second liquid feeding step, selecting the second flow path, and a third liquid feeding step of feeding a predetermined amount of the chemical liquid to the second flow path by sliding the piston from the position where the piston is slid by the predetermined distance toward the third position; .

According to the present embodiment, a chemical liquid feeder capable of repeatedly transferring a certain amount of a chemical liquid from a container filled with the chemical liquid to another container while suppressing the elution of foreign substances such as silicone oil into the chemical liquid. It is possible to provide a liquid device and a method for delivering a liquid medicine using the liquid delivery device.

1 is a perspective view illustrating the structure of a liquid delivery device according to a first embodiment; FIG. FIG. 4 is a cross-sectional view for explaining the operation of the liquid delivery device of the first embodiment; FIG. 10 is a plan view for explaining a modification of the regulating portion of the liquid delivery device of the first embodiment; FIG. 5 is a perspective view illustrating the structure of a liquid delivery device according to a second embodiment; FIG. 10 is a cross-sectional view for explaining the operation of the liquid delivery device of the second embodiment; FIG. 11 is a perspective view illustrating the structure of a liquid delivery device according to a third embodiment; FIG. 11 is a cross-sectional view for explaining the operation of the liquid delivery device of the third embodiment; FIG. 11 is a cross-sectional view for explaining the operation of the liquid delivery device of the fourth embodiment; FIG. 11 is a schematic diagram for explaining the configuration and operation of a liquid transfer system according to a fifth embodiment; FIG. 11 is another schematic diagram for explaining the operation of the liquid transfer system of the fifth embodiment; FIG. 11 is another schematic diagram for explaining the operation of the liquid transfer system of the fifth embodiment; FIG. 11 is a schematic diagram illustrating a modification of the liquid transfer system of the fifth embodiment; FIG. 11 is a schematic diagram illustrating another modified example of the liquid transfer system of the fifth embodiment;

Hereinafter, an example of a chemical solution delivery device and a chemical solution delivery method according to the present disclosure will be described with reference to drawings and the like. However, the chemical solution delivery device and the chemical solution delivery method of the present disclosure are not limited to the embodiments and examples described below.

In addition, each figure shown below is shown typically. Therefore, the size and shape of each part are appropriately exaggerated for easy understanding. In each figure, hatching indicating cross sections of members is omitted as appropriate. Numerical values such as dimensions and material names of each member described in this specification are examples as an embodiment, and are not limited to these, and can be appropriately selected and used. In this specification, terms specifying shapes and geometrical conditions, such as parallel, orthogonal, perpendicular, etc., not only have strict meanings but also include substantially the same states. Also, for convenience of explanation, the terms "upper" and "lower" are sometimes used, but the vertical direction may be reversed, and the same applies to the horizontal direction.

1. First Embodiment A first embodiment of the medical liquid delivery device of the present disclosure will be described. FIG. 1 is a perspective view showing an example of a chemical solution delivery device 1 of this embodiment. FIG. 2 is a cross-sectional view showing the structure and operation of the chemical solution delivery device 1 shown in FIG. FIG. 3 is a plan view showing a modification of the shape of the restricting portion 5 in this embodiment.

(a) Construction of the liquid medicine delivery device As shown in FIG. and a piston 3 to which a gasket 4 is attached. The piston 3 is also called pusher. One end of the cylinder 2 is formed with a nozzle portion 7, which is a protruding portion with a small diameter hole for sucking or discharging the chemical solution, and the other end opposite to the one end is provided with a wide flange. A cylinder opening 8 is formed.

The part of the piston 3 to which the gasket 4 is attached is set in a position overlapping the cylinder opening 8, and the piston tip 6, which is the end of the piston 3 opposite to the gasket 4, is inserted into the cylinder opening of the cylinder 2. The piston 3 can be inserted into the cylinder 2 by pushing in the direction from the portion 8 toward the nozzle portion 7 . Conversely, by pulling out the piston tip 6 from the nozzle 7 of the cylinder 2 in the direction toward the cylinder opening 8, the piston 3 can be ejected toward the outside of the cylinder 2.

When the piston 3 is inserted into or ejected from the cylinder 2, the gasket 4 maintains airtightness against the second inner surface 12, which is the inner surface near the cylinder opening 8 of the cylinder 2. Moving. That is, the piston 3 slides inside the cylinder 2 via the gasket 4 . Therefore, by moving the piston 3 of the liquid medicine delivery device 1 in the direction from the nozzle part 7 toward the cylinder opening 8 , the liquid medicine can be sucked into the cylinder 2 from the nozzle part 7 .

It should be noted that the cross-sectional shape of the cylinder 2 when cut along a plane perpendicular to the sliding direction of the piston 3 does not have to be circular. It may be a polygon, or it may constitute an arbitrary figure connected by straight lines or curved lines.

On the other hand, in a hollow portion inside the cylinder 2 , a restricting portion 5 that abuts on the second inner side surface 12 that is the inner side surface of the cylinder 2 is arranged. The restricting portion 5 is detachably or non-detachably fixed to the second inner surface 12 of the cylinder 2 , or is molded integrally with the cylinder 2 . When viewed in the direction from the cylinder opening 8 toward the nozzle portion 7, the plan view of the restricting portion 5A, which is the restricting portion 5 of the present embodiment, is as shown in FIG. It becomes the shape which has the ring part 21 of .

The inner diameter of the ring portion 21 of the restricting portion 5</b>A that is the restricting portion 5 is smaller than the outer diameter of the gasket 4 of the piston 3 . Therefore, when the piston 3 is inserted into the cylinder 2 , the movement of the gasket 4 , which is the tip of the piston 3 , from the cylinder opening 8 toward the nozzle portion 7 is restricted by the restricting portion 5 . That is, when the gasket 4 collides with the restricting portion 5 , the piston 3 comes closest to one end of the cylinder 2 having the nozzle portion 7 . Let the position of the piston 3 at this time be a 1st position.

This time, conversely, when the piston 3 is moved to discharge toward the outside of the cylinder 2, the gasket 4, which is the tip of the piston 3, is positioned on the second inner surface near the cylinder opening 8, as will be described later. Movement from the nozzle portion 7 toward the cylinder opening portion 8 is regulated at a location where the inner diameter of the nozzle portion 12 is partially narrowed. That is, when the gasket 4 collides with the portion of the inner diameter of the second inner surface 12 where the inner diameter is partially narrowed, the piston 3 comes to the farthest position from one end of the cylinder 2 having the nozzle portion 7 . Let the position of the piston 3 at this time be a 2nd position.

By the way, when the piston 3 is strongly moved to discharge further toward the outside of the cylinder 2, the gasket 4 overcomes the portion where the inner diameter of the second inner side surface 12 is partially narrowed, thereby causing the piston 3 to move toward the cylinder 2. from one end of the to a position further than the second position. In this case, the piston 3 is completely detached from the cylinder 2, and the cylinder 2 and the piston 3 of the liquid medicine delivery device 1 are separated.

The inner surface of the cylinder 2 can thus be divided into two sections with the restricting portion 5 fixed between them as a boundary. That is, the inner surface from one end of the cylinder 2 having the nozzle portion 7 to the other end of the cylinder 2 having the cylinder opening 8 includes a section including a contact portion with the restricting portion 5 from one end to the restricting portion 5. It has a first inner side surface 11 and a second inner side surface 12 as a section extending from the restricting portion 5 to the other end and not including the contact portion of the restricting portion 5 .

The second inner surface 12, which is the actual sliding range of the piston 3, is coated with, for example, silicone in order to reduce the frictional resistance between the gasket 4 and the second inner surface 12 and ensure good sliding motion of the piston 3. Oil or fluorine compounds can be applied.

On the other hand, the gasket 4 does not pass through the first inner surface 11, which is outside the sliding range of the piston 3. However, since this is a place where the chemical liquid comes into contact when the chemical liquid is sucked, silicone oil or fluorine-based oil is not used. No foreign substances, including compounds, should be applied.

(b) Operation and action of the chemical solution delivery device Next, the operation and action of the chemical solution delivery device 1 having the structure described above will be described. 2 shows openings of the cylinder opening 8 and the nozzle portion 7 when the cylinder 2 is viewed in the direction from the cylinder opening 8 of the cylinder 2 toward the nozzle portion 7 in the chemical liquid delivery device 1 shown in FIG. 1 is a cross-sectional view of the drug solution delivery device 1 cut along a plane passing through the center of the .

It is arranged so that the direction from the nozzle portion 7 of the cylinder 2 to the cylinder opening portion 8 is upward, and the opposite direction is downward. In the liquid medicine delivery device 1 of the present embodiment, both the cylinder opening 8 and the nozzle part 7 have substantially circular openings, but the openings are not limited to this, and may be substantially elliptical or substantially polygonal. Further, inside the cylinder 2, a restricting portion 5 (5A) is fixed.

Here, a plane perpendicular to the vertical direction passing through the end 7C of the nozzle portion 7 which is the lower end of the liquid medicine delivery device 1, a plane perpendicular to the vertical direction passing through the lower end of the regulating portion 5, and the first inside of the cylinder 2 A region surrounded by the side surfaces 11 is defined as a first region 13 . In addition, as described above, the cylinder opening 8, which is the upper end of the cylinder 2, has a portion where the inner diameter of the second inner surface 12 is partially narrowed, and the lower surface is the inner convex inner surface 8A, The surface on the upper side is defined as an inner projection outer surface 8B. At this time, it is surrounded by a plane perpendicular to the vertical direction passing through the upper end of the restricting portion 5, a plane perpendicular to the vertical direction passing through the inner convex outer surface 8B of the cylinder opening 8, and the second inner side surface 12 of the cylinder 2. A second region 14 is defined as the region where the

First, as shown in FIG. 2(a), the piston 3 can be pushed downward in the cylinder 2 by pushing the piston tip 6 of the piston 3 downward. When the gasket 4 is lowered to the position where the gasket 4 collides with the restricting portion 5, that is, the first position, the piston 3 cannot be moved downward any further.

Next, after the nozzle part 7 is immersed in the chemical solution 50, as shown in FIG. can be lifted. However, when the upper surface of the gasket 4 hits the inner convex inner surface 8A of the cylinder opening 8, that is, when it reaches the second position, the piston 3 cannot be moved upward any further.

When the piston 3 moves from the first position to the second position, it slides while maintaining airtightness via the gasket 4, so the first region 13 of the cylinder 2 becomes a negative pressure with respect to the outside. The chemical liquid 50 is sucked into the first region 13 from the nozzle portion 7 and the liquid surface rises. Here, the internal volume of the cylinder 2 from the end 7C of the nozzle portion 7 to the lower end surface of the gasket 4 of the piston 3 at the first position is V1. Also, let V2 be the internal volume of the cylinder 2 from the end 7C of the nozzle portion 7 to the lower end surface of the gasket 4 of the piston 3 at the second position. At this time, if the difference obtained by subtracting V1 from V2 is V3, V3 is the volume of the gasket 4 crossing the second region 14 when the piston 3 is moved from the first position to the second position, that is, the gasket 4 multiplied by the amount of vertical movement of the piston 3.

Here, when extremely high pressure is not applied to the chemical solution, it is important to set V1 to V3 or more, that is, to set V2 to twice or less than V1. By setting in this way, when the piston 3 is moved from the first position to the second position, the liquid level of the chemical liquid 50 sucked into the cylinder 2 exceeds the first region 13. It never rises to the top.

Therefore, the liquid level of the liquid medicine 50 sucked into the first area 13 exists in the area below the regulating portion 5 unless the liquid medicine delivery device 1 is tilted. Therefore, even if the second inner surface 12 of the cylinder 2 in the second region 14 is coated with silicone oil or a fluorine-based compound to improve the slidability of the piston 3, it does not come into contact with the chemical solution 50. Therefore, the risk of foreign substances eluting into the chemical solution 50 can be suppressed.

Furthermore, as shown in FIG. 2(c), when it is assumed that the flow path switching unit (not shown) is switched so that the delivery pipe path ahead of the nozzle unit 7 is directed to another container, again, By pushing the piston tip portion 6 of the piston 3 downward, the chemical liquid 50 sucked into the first region 13 can be discharged through the nozzle portion 7 toward another container.

In this manner, in the chemical liquid delivery device 1 of the present embodiment, the restriction portion 5 is provided on the inner surface of the cylinder 2 so that the piston 3 can enter only halfway into the cylinder 2. The piston 3 can be moved to the first position which is the limit position of the movement of the piston 3 . Conversely, the piston 3 can be moved in the opposite direction to the second position, which is the limit position where the piston 3 is pulled out of the cylinder 2 .

After moving the piston 3 to the first position, a container of the chemical solution 50 is arranged so that the chemical solution 50 can be sucked from the nozzle portion 7, and then the piston 3 is moved to the second position to obtain a predetermined amount of liquid. A chemical solution 50 can be sucked into the cylinder 2 . The first inner surface 11 of the first region 13 of the cylinder 2 to which the chemical is sucked is not coated with silicone oil or a fluorine-based compound because the gasket 4 does not come into contact with the first inner surface 11 . Furthermore, after switching the container connected first from the nozzle part 7 to another container, etc., by moving the piston 3 from the second position to the first position, an amount of the chemical solution 50 equivalent to the sucked amount can be extracted. can be discharged accurately toward another container.

Since the chemical solution 50 sucked into the cylinder 2 and discharged to the outside does not come into contact with the silicone oil or the fluorine-based compound applied to the second inner surface 12 of the cylinder 2, these foreign substances are inadvertently eluted into the chemical solution 50. can reduce the risk of

Further, in the above description, the amount of the liquid medicine to be sucked in one time is uniquely determined by moving the piston 3 from the first position to the second position. It may be any position closer to the first position than the position. In other words, it is not necessary to use the maximum amount of suction per one time due to the reciprocating movement of the piston 3 in the drug solution delivery device 1, and it is possible to arbitrarily determine a smaller amount of suction than this and repeatedly deliver the liquid at that amount. may For example, the amount of movement of the piston 3 may be determined by referring to the scale displayed on the cylinder 2 .

On the other hand, in the chemical solution delivery device 1 of the present embodiment, when the original chemical solution container is arranged so that the liquid surface is higher than the end 7C of the nozzle part 7, the pressure applied to the chemical solution 50 is Due to the increased height, there is a possibility that more liquid medicine than the planned suction amount will be sucked. For this reason, it is preferable to increase the ratio of V1 to V2, which is the aforementioned volume. For setting V1 and V2, it is necessary to consider the positional relationship in the height direction of the liquid level of the original chemical container and the chemical solution delivery device 1, the cross-sectional areas of the container and the cylinder 2, the density of the chemical solution, and the like.

(c) Modified Example of Regulation Portion of Chemical Liquid Delivery Device The regulation portion 5 of the chemical liquid delivery device 1 of the present embodiment is a plane when viewed in the direction from the cylinder opening 8 toward the nozzle portion 7 as described above. A diagram is shown in FIG. That is, the restricting portion 5A has a shape in which an opening 22 having a constant inner diameter and having a ring portion 21, which is an outer frame portion, is formed. However, it is sufficient that the restricting portion 5 can restrict the movement of the piston 3 so that the gasket 4 of the piston 3 does not advance beyond the specified position, and suppress the rise of the chemical liquid from below even a little.

Other modifications of the restricting portion 5 satisfying such conditions will be described below, but it goes without saying that various forms other than this can be used. For example, as shown in FIG. 3B, the first inner surface 11 has a protrusion 24 projecting from the first inner surface 11 toward the center with a relatively large width and a recess 23 projecting with a smaller width than this. It is good also as regulation part 5B formed repeatedly along. In this case also, an opening 22 having a fixed shape is formed in the center although the shape is different from that of the restricting portion 5A. By providing the concave portion 23 in this way, the flow rate of the air passing through the restricting portion 5 between the first region 13 and the second region 14 of the cylinder 2 can be increased, and the resistance when the piston 3 slides can be reduced. can be reduced.

Further, as shown in FIG. 3C, only two projections 25 from the first inner side surface 11 may be configured as a restricting portion 5C projecting toward the center. In this case, the flow rate of air passing through the restricting portion 5 between the first region 13 and the second region 14 of the cylinder 2 can be further increased, and the piston 3 can slide more smoothly.

On the other hand, as shown in FIG. 3(d), a film-like member 26 that covers the entire cross section of the cylinder 2 from the first inner surface 11 may be provided with a regulating portion 5D in which a large number of openings 27 are formed. In this case, the durability of the restricting portion 5 is increased, and the gasket 4 of the piston 3 can be made less likely to be damaged even when repeatedly hit.

Furthermore, as shown in FIG. 3(e), a restricting portion 5E in which the entire cross section of the cylinder 2 from the first inner surface 11 is covered with a filter 28 may be employed. In this case, if the filter 28 is made of a member that allows air to pass through sufficiently but does not allow the chemical solution to pass through, air resistance when the piston 3 slides can be reduced, and the durability of the restricting portion 5 can be improved. can also be improved. Furthermore, even if the chemical liquid tries to pass through the restricting portion 5 toward the second region 14 of the cylinder 2 due to high pressure, the filter 28 can prevent this. Therefore, it is possible to effectively suppress contamination of the chemical caused by the chemical coming into contact with silicone oil or the like applied to the second inner surface of the second region. In addition, since foreign matter other than such applied matter, such as foreign matter in the air, does not pass through, it is also effective in terms of maintaining the quality of the chemical solution.

Various members can be used as the filter 28. For example, cellulose acetate (CA), nylon, polyethylene, cellulose, glass fiber, and polyether having a pore size of 0.1 μm or more and less than 10 μm. Sulfone (PES), PTFE, polypropylene, MCE, PVDF, etc. can be used. This is because the method for testing insoluble fine particles for injections in the Japanese Pharmacopoeia stipulates fine particles having a particle size of 10 μm or more, and it is considered preferable that at least foreign substances of 10 μm or more do not contaminate the drug solution.

2. Second Embodiment Next, a second embodiment of the medical liquid delivery device of the present disclosure will be described, focusing on differences from the medical liquid delivery device of the first embodiment. FIG. 4 is a perspective view showing an example of the chemical solution delivery device 1A of this embodiment. 5A and 5B are cross-sectional views showing the structure and operation of the liquid medicine delivery device 1A shown in FIG.

(a) Configuration of the chemical solution delivery device As shown in FIG. 4, the chemical solution delivery device 1A has the same syringe structure as the chemical solution delivery device 1 of the first embodiment, and has a hollow inside the substantially cylindrical outer cylinder portion. and a piston 3A having a gasket 4 attached to its tip. A nozzle portion 7 is formed at one end of the cylinder 2, and a cylinder opening portion 8 is formed at the other end opposite to the one end.

Inside the cylinder 2, the regulating portion 5 is not arranged as in the first embodiment, and instead, a regulating portion 5F fixed to the piston 3A in a section from the gasket 4 of the piston 3A to the piston tip portion 6 is provided. is provided. The regulating portion 5F is also included in the regulating portion 5 of the liquid medicine delivery device of the present disclosure. The restricting portion 5F is a ring-shaped member having a diameter larger than the inner diameter of the gap of the cylinder opening 8, and is detachably or non-detachably fixed to the piston 3, or integrated with the piston 3A. is molded into

When the piston 3A is inserted into the cylinder 2, the movement of the gasket 4, which is the tip of the piston 3A, from the cylinder opening 8 toward the nozzle portion 7 is restricted by the restricting portion 5F. That is, when the restricting portion 5F collides with the cylinder opening portion 8, the piston 3A comes to the position closest to one end of the cylinder 2 having the nozzle portion 7. As shown in FIG. Let the position of piston 3A at this time be a 1st position.

This time, on the contrary, when the piston 3A is moved to discharge toward the outside of the cylinder 2, the gasket 4, which is the tip of the piston 3A, is moved near the cylinder opening 8 as described in the first embodiment. , it collides with a portion where the inner diameter of the second inner side surface 12 is partially narrowed. At this time, the piston 3A comes to the farthest position from one end of the cylinder 2 having the nozzle portion 7, and the position of the piston 3A at this time is defined as the second position.

Also, the inner surface of the cylinder 2 can be divided into two sections, unlike the first embodiment, which does not use the restricting portion 5F as a boundary. That is, the section from one end of the inner surface from one end of the cylinder 2 having the nozzle portion 7 on the inner surface to the other end of the cylinder 2 having the cylinder opening 8 to just before the position of the gasket 4 at the first position and a second inner surface 12 as a section from the position of the gasket 4 at the first position to the other end.

The second inner surface 12 of the cylinder 2, which is the actual sliding range of the piston 3A, is provided with a For example, silicone oil or a fluorine-based compound can be applied. In addition, the gasket 4 does not pass through the first inner surface 11 of the cylinder 2, which is outside the sliding range of the piston 3A. It should not be smeared with any foreign matter, including oils and fluorochemicals.

(b) Operation and action of the chemical solution delivery device Next, the operation and action of the chemical solution delivery device 1A will be described. FIG. 5 is a cross-sectional view of the liquid medicine delivery device 1A viewed in the same way as in FIG. It is arranged so that the direction from the nozzle portion 7 of the cylinder 2 to the cylinder opening portion 8 is upward, and the opposite direction is downward.

First, as shown in FIG. 5(a), the piston 3A can be pushed downward in the cylinder 2 by pushing the piston tip 6 of the piston 3 downward. However, when the restriction portion 5F is lowered to the position where it collides with the cylinder opening portion 8, that is, the first position, the piston 3 cannot be moved downward any further.

Next, after the nozzle portion 7 is immersed in the chemical solution, as shown in FIG. 5B, the piston tip portion 6 of the piston 3 is pulled upward to pull the piston 3A upward from the cylinder 2. be able to. However, when the upper surface of the gasket 4 hits the inner convex inner surface 8A of the cylinder opening 8, that is, when it reaches the second position, the piston 3A cannot be moved upward any further.

Here, a plane perpendicular to the vertical direction passing through the end 7C of the nozzle portion 7, which is the lowest end of the liquid medicine delivery device 1, passes through the boundary between the upper end of the first inner surface 11 and the lower end of the second inner surface 12. A first region 13 is a region surrounded by a plane perpendicular to the vertical direction and the first inner side surface 11 of the cylinder 2 . In addition, as described above, the cylinder opening 8, which is the upper end of the cylinder 2, has a portion where the inner diameter of the second inner surface 12 is partially narrowed, and the lower surface is the inner convex inner surface 8A, The surface on the upper side is defined as an inner projection outer surface 8B. At this time, a plane perpendicular to the vertical direction passing through the boundary between the upper end of the first inner side surface 11 and the lower end of the second inner side surface 12, and a plane perpendicular to the vertical direction passing through the inner convex outer surface 8B of the cylinder opening 8 A region surrounded by the plane and the second inner side surface 12 of the cylinder 2 is defined as a second region 14 .

When the piston 3A moves from the first position to the second position, the chemical liquid 50 is sucked into the first region 13 from the nozzle portion 7 and the liquid level rises. Here, the relationships and requirements of the volumes V1, V2, V3 described in the first embodiment also apply to this embodiment.

Therefore, in the present embodiment as well, the medical solution 50 sucked into the first region 13 does not cross the boundary between the upper end of the first inner surface 11 and the lower end of the second inner surface 12 unless the medical solution delivery device 1 is tilted. Beyond this, the chemical solution 50 is prevented from entering the second region 14 . Therefore, even if the second inner surface 12 of the cylinder 2 in the second region 14 is coated with silicone oil or a fluorine-based compound to improve the slidability of the piston 3A, it does not come into contact with the chemical solution 50. Therefore, the risk of foreign substances eluting into the chemical solution 50 can be suppressed.

Furthermore, as shown in FIG. 5(c), by pushing down the piston tip 6 of the piston 3A again, the liquid medicine 50 sucked into the first region 13 is transferred to another container through the nozzle portion 7. can be directed and discharged.

As described above, in the drug solution delivery device 1A of the present embodiment as well, the restricting portion 5F is provided in the middle of the piston 3A so that the piston 3A can enter only halfway into the cylinder 2. The piston 3A can be moved to the first position, which is the limit position of the movement of 3A. Conversely, the piston 3A can be moved in the opposite direction to the second position, which is the limit position where the piston 3A is pulled out of the cylinder 2.

Also in the present embodiment, the chemical solution 50 that is sucked into the cylinder 2 and discharged to the outside does not come into contact with the silicone oil or the fluorine-based compound applied to the second inner surface of the cylinder 2. The risk of these foreign substances eluting into the chemical solution 50 can be suppressed. Further, in this embodiment, since the restricting portion 5F is fixed to the piston 3A that can be removed from the cylinder 2, if the restricting portion 5F is detachable from the piston 3A or the mounting position can be adjusted. In the case of a structure, these attachment/detachment work and adjustment work can be easily performed, and furthermore, there is no possibility that the regulation portion 5F will come into contact with the chemical liquid 50, so the range of material selection for the regulation portion 5F can be widened.

3. Third Embodiment Next, a third embodiment of the medical liquid delivery device of the present disclosure will be described. FIG. 6 is a perspective view showing an example of the medical liquid delivery device 1B of this embodiment. 7A and 7B are cross-sectional views showing the structure and operation of the liquid medicine delivery device 1B shown in FIG.

(a) Structure of chemical liquid delivery device As shown in FIG. 6, a chemical liquid delivery device 1B has only a second liquid delivery section 17 having a structure corresponding to the chemical liquid delivery device 1 of the first embodiment and a cylinder structure. It is composed of a first liquid feeding section 16 and a connecting pipe 15 connecting the two. The second liquid feeding section 17 has a second cylinder 2B having a cavity inside a substantially cylindrical outer cylinder portion, and a piston 3 having a gasket 4 attached to its tip. One end of the second cylinder 2B has a second connecting portion 7B with a small diameter hole, and the second cylinder 2B is connected to the connecting pipe 15 via the second connecting portion 7B. At the opposite end, a wide flanged cylinder opening 9 is formed.

On the other hand, the first liquid feeding section 16 is composed of a first cylinder 2A having a cavity inside a substantially cylindrical outer cylinder portion, and one end of the first cylinder 2A has a small diameter for sucking or discharging the chemical liquid. A nozzle portion 7A, which is a projecting portion with a hole, is formed, and the other end opposite to the one end has a first connection portion 9C with a hole. One cylinder 2A is connected to a connecting pipe 15.

The mounting portion of the gasket 4 of the piston 3 of the second liquid feeding portion 17 is set at a position overlapping the cylinder opening 9, and the piston tip portion 6, which is the end of the piston 3 opposite to the side where the gasket 4 is present, is moved to the second position. The piston 3 can be inserted into the second cylinder 2B by pushing it from the cylinder opening 9 of the second cylinder 2B in the direction toward the second connecting portion 7B. Conversely, by pulling out the piston tip portion 6 from the second connection portion 7B of the cylinder 2 in the direction toward the cylinder opening portion 9, the piston 3 can be ejected toward the outside of the second cylinder 2B.

When the piston 3 is inserted into or ejected from the cylinder 2, the gasket 4 moves airtightly against the second inner surface 12A, which is the entire inner surface of the second cylinder 2B. That is, the piston 3 slides through the gasket 4 inside the second cylinder 2B. By moving the piston 3 of the liquid medicine delivery device 1B from the second connection part 7B in the direction toward the cylinder opening 9, the inside of the first liquid delivery part 16 spaced apart by the connecting pipe 15 becomes negative with respect to the outside. It becomes a pressure, and the liquid medicine can be sucked.

When the piston 3 is inserted into the second cylinder 2B, the movement of the gasket 4, which is the tip of the piston 3, from the cylinder opening 9 toward the second connecting portion 7B is restricted by the restricting portion 5. Thus, when the gasket 4 collides with the restricting portion 5, the piston 3 comes to the position closest to one end of the second cylinder 2B having the second connecting portion 7B. Let the position of the piston 3 at this time be a 3rd position. Note that the restricting portion 5 does not necessarily have to be provided in the middle section from the second connecting portion 7B inside the second cylinder 2B to the cylinder opening portion 9. For example, the restricting portion 5 is excluded in FIG. However, since the second connecting portion 7B of the second cylinder 2B itself is tapered, the gasket 4 of the piston 3 comes into contact with the inner wall of the second cylinder 2B forming the second connecting portion 7B, causing the piston 3 to slide. may be a structure in which is regulated. That is, in this case, the inner wall itself of the second cylinder 2B forming the second connecting portion 7B functions as the restricting portion 5. As shown in FIG.

This time, conversely, when the piston 3 is moved so as to discharge toward the outside of the second cylinder 2B, the gasket 4 at the tip of the piston 3 moves toward the inner diameter of the second inner surface 12A near the cylinder opening 9. The movement from the second connecting portion 7B toward the cylinder opening 9 is regulated at the location where the portion of the connecting portion 7B is narrowed. That is, when the gasket 4 collides with the portion of the second inner side surface 12A where the inner diameter is partially narrowed, the piston 3 comes to the farthest position from one end of the second cylinder 2B having the second connecting portion 7B. Let the position of the piston 3 at this time be a 4th position.

By the way, as in the first embodiment, when the piston 3 is strongly moved further toward the outside of the second cylinder 2B so as to be ejected, the inner diameter of the second inner surface 12A of the gasket 4 is partially narrowed. The piston 3 can move beyond the fourth position from the end of the second cylinder 2B having the second connecting portion 7B. In this case, the piston 3 is completely detached from the second cylinder 2B, and the second cylinder 2B and the piston 3 of the liquid medicine delivery device 1B are separated.

In addition, on the second inner surface 12A of the second cylinder 2B, which is the actual sliding range of the piston 3, the frictional resistance between the gasket 4 and the second inner surface 12A is reduced so that the piston 3 can slide smoothly. In order to secure it, for example, silicone oil or a fluorine-based compound can be applied.

(b) Operation and Action of the Medical Solution Delivery Device Next, the action and action of the medical solution delivery device 1B having the structure described above will be described. FIG. 7 shows the cylinder opening 9 and the second cylinder 2B when the second cylinder 2B is viewed in the direction from the cylinder opening 9 of the second cylinder 2B toward the second connecting portion 7B for the chemical liquid delivery device 1B shown in FIG. FIG. 2 is a cross-sectional view of the medical solution delivery device 1B when the drug solution delivery device 1B is cut along a plane passing through the center of each opening of two connection parts 7B.

FIG. 7 is a diagram showing the arrangement so that the direction from the second connecting portion 7B of the second cylinder 2B to the cylinder opening 9 is upward, and the opposite direction is downward. Similarly, the direction from the nozzle portion 7A of the first cylinder 2A to the first connecting portion 9C is arranged upward, and the opposite direction is arranged downward. In the chemical liquid delivery device 1B of the present embodiment, the cylinder opening 9, the second connection 7B, the first connection 9C, and the nozzle 7A all have substantially circular openings, but are not limited thereto. It may be substantially elliptical or substantially polygonal.

Further, as described above, the cross-sectional shape of the second cylinder 2B taken along a plane perpendicular to the sliding direction of the piston 3 may be any shape other than a circular shape. In addition to this, the cross-sectional shape of the first cylinder 2A when the first cylinder 2A is cut along a plane perpendicular to the direction from the nozzle portion 7A to the first connection portion 9C can be an arbitrary shape like the second cylinder 2B. can be applied, and it is not necessary to have the same cross-sectional shape along the direction from the nozzle portion 7A to the first connection portion 9C. This is because the first cylinder 2A is separated from the second cylinder 2B and the piston 3 does not slide, so there is no need to keep the cross-sectional shape constant along the direction from the nozzle portion 7A to the first connection portion 9C. .

For this reason, for example, the cross section may decrease stepwise or continuously along the direction from the first connecting portion 9C of the first cylinder 2A toward the nozzle portion 7A. For example, it may have a substantially conical shape. In this way, if the first cylinder 2A is shaped so that it tapers from the first connecting portion 9C toward the nozzle portion 7A, it is possible to facilitate the discharge of the liquid medicine sucked into the first region 13A.

In addition, the cross section of the first cylinder 2A does not need to have the same shape and size as the cross section of the second cylinder 2B. The inner diameter of the first region 13A in the cross section of the first cylinder 2A may be smaller than the inner diameter of the second region 14A in the cross section of the second cylinder 2B so as to facilitate storage of the liquid medicine. may be

Here, in FIG. 7A, the internal region of the first cylinder 2A from the nozzle portion 7A at the lower end of the first liquid feeding portion 16 of the chemical liquid feeding device 1B to the first connecting portion 9C is defined as a first region 13A. . In addition, as described above, the cylinder opening 9, which is the upper end of the second cylinder 2B, has a portion where the inner diameter of the second inner surface 12 is partially narrowed, and the lower surface thereof is the inner convex inner surface 9A. , and the surface on the upper side is defined as an inner convex portion outer surface 9B. At this time, it is surrounded by a plane perpendicular to the vertical direction passing through the upper end of the restricting portion 5, a plane perpendicular to the vertical direction passing through the inner convex outer surface 9B of the cylinder opening 9, and the second inner side surface 12A of the cylinder 2. A second area 14A is defined as the area where the

First, as shown in FIG. 7(a), by pushing the piston tip 6 of the piston 3 of the second liquid feeding section 17 downward, the piston 3 can be pushed downward in the second cylinder 2B. However, when the gasket 4 descends to the position where the gasket 4 collides with the restricting portion 5, that is, the third position, the piston 3 cannot be moved downward any further.

Next, after the nozzle portion 7A of the first liquid feeding portion 16 is immersed in the chemical liquid, as shown in FIG. 7B, the piston tip portion 6 of the piston 3 of the second liquid feeding portion 17 is pulled upward. As a result, the piston 3 can be lifted upward toward the second cylinder 2B. However, when the upper surface of the gasket 4 hits the inner convex inner surface 9A of the cylinder opening 9, that is, when it reaches the fourth position, the piston 3 cannot be moved upward any further.

When the piston 3 moves from the third position to the fourth position, it slides through the gasket 4 while maintaining airtightness. Therefore, the second region 14A of the second cylinder 2B and the first region 13A of the first cylinder 2A connected thereto via the connecting pipe 15 become negative pressure, and the chemical solution 50 is discharged from the nozzle portion 7A into the first region 13A. , and the liquid level inside the first cylinder 2A rises. Here, the internal volume of the first cylinder 2A from the end 7C of the nozzle portion 7A of the first liquid feeding portion 16 to the lower end surface of the gasket 4 of the piston 3 of the second liquid feeding portion 17 at the third position , the volume inside the connecting pipe 15, and the volume inside the second cylinder 2B is V4.

Further, the internal volume of the first cylinder 2A from the end 7C of the nozzle portion 7A of the first liquid feeding portion 16 to the lower end surface of the gasket 4 of the piston 3 of the second liquid feeding portion 17 at the fourth position, the connection Let V5 be the sum of the volume inside the tube 15 and the volume inside the second cylinder 2B. At this time, if the difference obtained by subtracting V4 from V5 is V6, V6 is the volume of the gasket 4 crossing the second region 14A when the piston 3 is moved from the third position to the fourth position, that is, the gasket 4 multiplied by the amount of vertical movement of the piston 3.

Here, when the chemical solution is not under extremely high pressure, it is important to set V4 to V6 or more, that is, to set V5 to twice or less than V4. With this setting, when the piston 3 is moved from the third position to the fourth position, the liquid surface of the chemical liquid 50 sucked into the first cylinder 2A of the first liquid feeding section 16 rises to the 2 It does not rise up to the liquid feeding section 17 .

Therefore, the liquid level of the chemical liquid 50 sucked into the first region 13A of the first cylinder 2A in the first liquid feeding section 16 rises to the second liquid feeding section 17 unless the liquid chemical liquid feeding device 1B is tilted. no. For this reason, even if the second inner surface 12A of the second region 14A of the second cylinder 2B in the second liquid feeding portion 17 is coated with silicone oil or a fluorine-based compound to improve the slidability of the piston 3, However, this does not come into contact with the chemical solution 50, and the risk of foreign substances eluting into the chemical solution 50 can be suppressed. In addition, since the first liquid-feeding unit 16 and the second liquid-feeding unit 17 are separated from each other by a connecting pipe 15 of arbitrary length, the length of the connecting pipe 15 is By making adjustments as necessary, it is possible to enhance the safety of preventing foreign matter from eluting into the chemical solution 50 .

The material, length, flexibility, etc. of the connecting pipe 15 can be freely changed. The positional relationship between the portion 16 and the second liquid feeding portion 17 can be freely determined. As a result, if the position of the first liquid feeding unit 16 is kept constant, even if the position of the second liquid feeding unit 17 is changed, the suction and discharge performance of the liquid medicine does not change, and it can be freely adjusted according to the work style. The arrangement of the second liquid feeding section 17 can be set. In addition, by using the connecting pipe 15 formed linearly or curvedly with a rigid member having no flexibility, the first liquid feeding section 16 and the second liquid feeding section 17 are fixed in a predetermined positional relationship. You can also connect. Furthermore, the connecting pipe 15 may be non-removably connected to the first liquid feeding section 16 and the second liquid feeding section 17, or may be detachably connected.

In addition, as in the first embodiment, the amount of liquid medicine sucked in one time is uniquely determined by moving the piston 3 from the third position to the fourth position. The position may be any position closer to the fourth position than the third position. In addition, the restricting portion 5 arranged inside the second cylinder 2B of the second liquid feeding portion 17 not only has a function as a stopper for the piston 3, but also has a filter function to prevent foreign substances from passing through. Advantages are also common to the first embodiment.

4. Fourth Embodiment Next, although similar to the third embodiment, a fourth embodiment of the medical solution delivery device of the present disclosure will be described mainly focusing on differences from the third embodiment. FIG. 8 is a cross-sectional view similar to FIG. 7 showing an example of the liquid medicine delivery device 1C of the present embodiment.

(a) Configuration of the chemical liquid delivery device As shown in FIG. 8, the chemical liquid delivery device 1C has a structure similar to that of the chemical liquid delivery device 1B of the third embodiment. It is composed of a second liquid feeding section 17 having a corresponding structure, a first liquid feeding section 16 having only a cylinder structure, and a connecting pipe 15 connecting the two. The difference from the third embodiment is that the second liquid feeding section 17 is not provided with a regulating section, and the connecting pipe that connects the first liquid feeding section 16 and the second liquid feeding section 17 has a filter structure. is to have

(b) Actions and actions of the chemical solution delivery device The actions and actions of the chemical solution delivery device 1C will be described. First, as shown in FIG. 8A, by pushing downward the piston tip portion 6 of the piston 3 of the second liquid feeding portion 17, the piston 3 can be pushed downward in the second cylinder 2B. In this embodiment, unlike the third embodiment, the restricting portion is not provided, so the gasket 4 can move to the lower end position without colliding with the restricting portion on the way. Let this position be the third position in the present embodiment.

Next, after the nozzle portion 7A of the first liquid feeding portion 16 is immersed in the chemical liquid, as shown in FIG. 8B, the piston tip portion 6 of the piston 3 of the second liquid feeding portion 17 is pulled upward. As a result, the piston 3 can be lifted upward toward the second cylinder 2B. However, when the upper surface of the gasket 4 collides with the inner convex inner surface 9A of the cylinder opening 9, that is, when it reaches the fourth position, the piston 3 cannot be moved upward any more. It is similar to the embodiment.

When the piston 3 moves from the third position to the fourth position, the chemical liquid 50 is sucked into the first region 13A from the nozzle portion 7A, and the liquid level inside the first cylinder 2A rises. The relationships among the volumes V4, V5 and V6 described in the third embodiment are applied in exactly the same way to this embodiment.

As shown in FIG. 7(b), after a certain amount of the chemical solution 50 is sucked into the first region 13A of the first liquid feeding section 16, the piston tip portion of the piston 3 is drawn again as shown in FIG. 7(c). 6 is pushed downward, the chemical liquid 50 sucked into the first region 13A of the first liquid feeding section 16 can be discharged toward another container through the nozzle section 7A.

At this time, the filter unit 60, which also serves as a connecting pipe connecting between the first liquid feeding section 16 and the second liquid feeding section 17, connects the first connecting section 9C of the first liquid feeding section 16 and the second liquid feeding section 9C. It is connected to the second connecting portion 7B of the portion 17, and gas is transferred through a filter having a predetermined pore size. The pore size is, for example, 0.1 μm or more and less than 10 μm. By pushing the piston tip 6 of the piston 3 downward and pushing out the air stored in the second region 14A of the second liquid feeding section 17 to the first region 13A of the first liquid feeding section 16, the first liquid feeding section The liquid medicine 50 sucked into the first region 13A of 16 can be discharged toward another container via the nozzle portion 7A. Here, since the air that pushes out the chemical liquid 50 in the first region 13A of the first liquid feeding section 16 passes through the filter of the filter unit 60, harmful foreign matter of 10 μm or more, for example, is removed.

Therefore, in the unlikely event that the gasket 4 of the piston 3 slides against the second cylinder 2B of the second liquid feeding section 17, the components of the gasket 4 or the second cylinder 2B are peeled off, and the first liquid feeding section 16, it is reliably removed by the filter contained in the filter unit 60. Therefore, the risk of such foreign matter being mixed with the chemical solution 50 can be reduced as much as possible.

The structure of the filter unit 60 will be explained according to FIG. 8(d). FIG. 8(d) is a cross-sectional view taken along a plane passing through the central axes of the upper and lower openings of the filter unit 60. FIG. The filter unit 60 includes a third connection portion 63 and a fourth connection portion 64 having openings as connection portions for connection with an external distribution pipe or the like. A filter case 62 is provided to protect the filter 61 and to provide airtightness against gas and liquid. As the filter 61, members similar to those exemplified for the filter 28 in the first embodiment can be used.

Such a structure is advantageous in that replacement and cleaning of only the filter portion can be easily performed without affecting the other structures of the liquid medicine delivery device 1C. In addition, it is possible to appropriately change the conditions, such as changing the pore size, depending on the chemical solution to be used and the required foreign matter removal performance.

5. Fifth Embodiment Next, as a fifth embodiment, a liquid feeding method by a liquid medicine feeding system using the liquid medicine feeding device 1B of the third embodiment will be described. Needless to say, the chemical liquid delivery device used in the liquid delivery system can be similarly applied to any of the first, second and fourth embodiments. 9 to 11 are schematic diagrams for explaining the configuration of the chemical solution delivery system and the chemical solution delivery method according to the fifth embodiment.

(a) Chemical Solution Delivery System FIG. 9 shows a schematic diagram of a chemical solution delivery system 30 of the present disclosure. The liquid delivery system 30 includes a first container 32 that stores a liquid chemical 50 and serves as a liquid delivery source, a second container 33 that serves as a liquid delivery destination to which a predetermined amount of the liquid chemical 50 is to be transferred, It is composed of a liquid medicine delivery device 31 (1B) for temporarily sucking the liquid medicine 50 from the second container 33 and then discharging the liquid medicine 50 into the second container 33, and delivery pipes connecting each part. The delivery pipes include a first delivery pipe 34 that connects the first container 32 and the flow path switching section 38, a second delivery pipe 35 that connects the flow path switching section 38 and the second container 33, and a chemical liquid feed. At least a third distribution pipe 36 that connects the instrument 31 and the flow path switching section 38 is provided.

The third delivery pipe 36 not only has the function of transferring the medical solution 50 between the first container 32 , the second container 33 and the medical solution delivery device 31 , but also the first delivery part 16 of the medical solution delivery device 31 . It may function as part of cylinder 2A. That is, the third delivery pipe 36 can be regarded as part of the capacity of the first region 13A of the liquid medicine delivery device 31, and can function as an expanded capacity of the first region 13A. Therefore, by utilizing the third delivery pipe 36 , it is possible to suck and discharge more liquid medicine 50 than the capacity of the first region 13</b>A of the liquid medicine delivery device 31 .

The channel switching unit 38 is a so-called three-way stopcock, which is connected to three delivery pipes and selects two of them to activate the channel. A switching method using a manual handle or an automatic switching method using an electromagnetic valve or the like may be used. Moreover, instead of the three-way stopcock, the channel switching unit 38 may be a Y-tube without a switching mechanism. In this case, the flow path can be switched by adjusting the pressure in the delivery pipe connected to the Y-shaped pipe by pressing or releasing it from the outside.

As shown in FIG. 9, the first container 32 is connected to the first delivery pipe 34 at the bottom surface 39, which is the lower end thereof. As a member of the first container 32, an arbitrary material having resistance to chemicals such as hard resin, soft resin, and glass can be used. The second container 33 is similarly connected to the second delivery pipe 35 at its bottom surface 40 . Any material can be used for the member of the second container 33 as well as the first container. The height at which the bottom surface 39 of the first container 32 and the bottom surface 40 of the second container 33 are arranged is about the same height as the lower end of the chemical liquid delivery device 31, that is, the lower end of the first cylinder 2A of the first liquid delivery section 16. It is preferable to Moreover, it is preferable to keep the relationship of these heights as constant as possible. If these heights fluctuate, there is a possibility that the amount of liquid medicine that is greater than or less than the planned volume calculated from the amount of movement of the piston 3 during liquid feeding may be aspirated. This is because it is necessary to correct the amount.

In addition, as will be described later, the first container 32 preferably has a structure that allows the container to be turned upside down. The reversing operation can be done automatically or manually. This is because it is necessary to return to the first container 32 part of the chemical liquid that has been excessively sucked into the chemical liquid delivery device 31 .

(b) Method for Transferring Chemical Solution First, as shown in FIG. 9, the above-described chemical solution transfer device 31 is prepared. In addition, this is connected to the first container 32 and the second container 33 via the channel switching section 38 with various distribution pipes as described above. This is referred to as a delivery pipe connecting step. Also, the setting of the channel switching unit 38 is switched so that the first distribution pipe 34 and the third distribution pipe 36 are connected. By pulling up the piston 3 of the second liquid feeding portion 17 of the chemical liquid feeding device 31 from the third position, the piston 3 moves to the fourth position and stops. By this operation, from the bottom surface 39 of the lower end of the first container 32, via the first delivery pipe 34, the flow path switching part 38 and the third delivery pipe 36, the first liquid delivery part 16 of the drug solution delivery device 31 is discharged. A predetermined amount of chemical solution 50 is sucked into one cylinder 2A. This is referred to as the first liquid feeding step.

It should be noted that the piston 3 may be pulled up to an arbitrary position between the third and fourth positions and stopped without being moved to the fourth position. This is because there are cases where it is desirable to set the volume of the liquid medicine to be sucked at one time to be smaller than the capacity of the first region 13A of the liquid medicine delivery device 31 or the capacity of the first cylinder 2A. An arbitrary position in this case may be determined, for example, by referring to a scale or the like displayed on the side surface of the first cylinder 2A. Similarly, first, without moving the piston 3 to the third position, it is stopped at an arbitrary position between the third position and the fourth position before the third position. good too. That is, the suction start position and suction end position of the chemical liquid 50 of the piston 3 are determined not as the third position and the fourth position, but as arbitrary two positions between the third position and the fourth position. may The arbitrary two positions in this case can be determined with reference to the scale or the like displayed on the side surface of the first cylinder 2A, as described above.

Next, as shown in FIG. 10, the first container 32 is turned upside down. Thereby, the bottom surface 39 of the first container 32 is arranged at the top. Further, the bottom surface 39 is arranged at a height equal to or lower than the lower end of the chemical liquid delivery device 31, that is, the lower end of the first cylinder 2A of the first liquid delivery section 16. As shown in FIG. Due to this operation, the surplus liquid medicine 50 that has been excessively sucked due to the liquid surface of the liquid medicine 50 being arranged at a position higher than the liquid medicine delivery device 31 is again discharged into the third delivery pipe 36 and the first delivery pipe. 34 is reversed back into the first container. This is referred to as a second liquid feeding step.

In FIG. 10, when the first container 32 is at the first container position 42, the drug solution 50 flowing from the bottom surface 39 of the first container 32 into the first delivery pipe 34 is pushed out by the weight of the drug solution 50 itself. In the chemical solution delivery device 31 , the volume of the chemical solution 50 larger than the volume corresponding to the upward movement of the piston 3 of the second liquid delivery portion 17 enters the first cylinder 2</b>A of the first liquid delivery portion 16 . Due to the pressure of the chemical liquid 50, the air inside the first cylinder 2A of the first liquid feeding section 16 and the air inside the second cylinder 2B of the second liquid feeding section 17 are compressed, and the chemical liquid 50 enters in excess. is. In addition, excessive chemical solution 50 may similarly enter due to slight expansion of the delivery pipe or cylinder due to the pressure of the chemical solution.

Here, when the first container 32 is placed in the second container position 43, that is, when the first container 32 is turned upside down so that the bottom surface 39 of the first container 32 comes to the upper end, the chemical solution 50 flowing through the first delivery pipe 34 is , the pressure due to its own weight is released, and the chemical solution 50 that has surplusly entered the first cylinder 2A of the first liquid sending unit 16 flows back through the first delivery pipe 34 and returns to the first container 32. . As a result, the correct volume of the liquid medicine 50 corresponding to the amount by which the piston 3 of the second liquid feeding section 17 has risen can be stored inside the first cylinder 2A of the first liquid feeding section 16 .

When the first container 32 is at the second container position 43, the bottom surface 39 preferably has a height equal to or lower than the lower end of the first liquid feeding section 16 of the chemical liquid feeding device 31, that is, the height of the nozzle section 7A. The liquid level of the liquid medicine 50 inside the first container 32 is reliably set at a position lower than the liquid level of the liquid medicine 50 in the first liquid feeding portion of the liquid medicine liquid feeding device 31, so that the liquid medicine 50 that has entered excessively can be removed. It is because it can return to the 1st container 32 favorably.

After transferring a predetermined amount of the chemical solution 50 from the first container 32, which is the source of the chemical solution 50, to the chemical solution delivery device 31 via the delivery pipe, the first container 32 is turned upside down. By lowering the liquid surface position, the pressure of the chemical solution 50 in the first container 32 is reduced, and the surplus chemical solution 50 sucked into the chemical solution delivery device 31 is sent back to the first container 32 so that the chemical solution delivery device 31 The method of properly correcting the suction amount of the chemical solution 50 to the septum can also be applied when the chemical solution delivery device 31 is not used. That is, even if the chemical solution delivery device 31 is replaced with a normal syringe that can suck the chemical solution into the sliding range of the piston of the cylinder, the appropriate amount of the chemical solution can be transferred by the method of transferring the chemical solution. It becomes possible.

Next, as shown in FIG. 11, the channel switching unit 38 is set so that the first distribution pipe 34 and the third distribution pipe 36 are disconnected, and the third distribution pipe 36 and the second distribution pipe 35 are connected. switch to Note that after the setting of the channel switching unit 38 is switched, the position of the first container 32 may be returned to the first container position 42 or may remain at the second container position 43 . Then, by pushing the piston 3 of the second liquid feeding portion 17 of the chemical liquid feeding device 31 downward, the piston 3 moves from the fourth position to the third position and stops.

At the third position, the gasket 4 at the tip of the piston 3 is in contact with the restricting portion 5 fixed inside the second cylinder 2B of the second liquid feeding portion 17 . By this operation, a predetermined amount of the chemical liquid 50 sucked and stored inside the first cylinder 2A of the first liquid feeding section 16 of the chemical liquid feeding device 31 is transferred to the third delivery pipe 36, the flow path switching section 38 and the second cylinder 2A. It is discharged into the inside of the second container 33 from the bottom surface 40 at the lower end of the second container 33 via the delivery pipe 35 . This is referred to as a third liquid feeding step.

Through the above steps, a predetermined amount of the chemical solution 50 stored in the first container 32 can be temporarily aspirated by the chemical solution delivery device 31 and delivered to the second container 33, which is another container. In particular, for the chemical solution 50 once sent to the chemical solution sending device 31 in the first solution sending step, a second liquid sending step is added to return the surplus sent liquid due to the weight of the chemical solution in the first container 32 to the first container 32. Accordingly, it is possible to deliver an accurate amount of the chemical solution 50 . Furthermore, in the chemical liquid delivery device 31, the second liquid delivery section 17, in which the piston 3 slides, and the first liquid delivery section 16, in which the chemical liquid 50 is sucked and discharged, are separated by the connecting pipe 15. Therefore, it is possible to reduce the risk that foreign substances such as silicone oil applied to the first cylinder 2A to improve the slidability of the piston 3 will be eluted into the chemical solution 50 .

Furthermore, if the restricting portion 5 that restricts the amount of movement of the piston 3 fixed to the first cylinder 2A of the second liquid feeding portion 17 is provided with a filtering function that prevents foreign matter of a certain size or larger from passing through, It is also possible to suppress the elution of foreign matter such as dust generated from the gasket 4 when the piston 3 slides into the chemical solution 50 .

Further, as described above, the medical liquid delivery device 31 may be replaced with the medical liquid delivery device 1C of the fourth embodiment. In this case, the second liquid feeding section 17 does not have a regulating section, and a foreign object of a certain size or larger cannot pass through the middle of the connecting pipe 15 connecting the first liquid feeding section 16 and the second liquid feeding section 17. A filter unit 60 having a filter function is arranged. This effectively suppresses elution of foreign substances that may occur in the second liquid feeding section 17 into the chemical solution 50 . Moreover, even if the suction amount of the chemical solution 50 from the first container 32 increases due to the high pressure and the chemical solution 50 tries to move from the first liquid sending unit 16 toward the second liquid sending unit 17, the filter If the filter used in the unit 60 has an appropriate pore size, the chemical solution 50 cannot pass through the filter, and contamination due to unintended overflow of the chemical solution can be prevented.

In the liquid medicine delivery method of the present embodiment, the initial state is a state in which the inside of each of the first delivery pipe 34, the second delivery pipe 35, and the third delivery pipe 36 is filled with the liquid medicine 50 in advance. and the case where the initial state is a state in which the inside of each delivery pipe is filled with air. In the former case, there is almost no air in the delivery pipe connecting the first container 32, the chemical solution delivery device 31 and the second container 33, and the air is compressed when the pressure of the chemical solution 50 changes during delivery. Fluctuations in the amount of liquid sent due to expansion are suppressed, so liquid can be sent relatively stably.

On the other hand, in the latter case, the preparatory work of filling each delivery pipe with the chemical solution 50 in advance is not required, so that the solution can be sent quickly with simple preparation. Basically, the shorter the length of each delivery pipe, the less likely it is to be affected by the compression and expansion of the air caused by the pressure change of the chemical liquid 50 during liquid delivery. However, as in the present embodiment, by interposing the second liquid feeding step of turning the first container 32 upside down, the effect of air compression and expansion during liquid feeding can be corrected. Accurate liquid transfer similar to the case where the inside of the tube is previously filled with the chemical liquid 50 is possible.

Further, when the inside of the delivery pipe is filled with air, when the piston 3 of the drug solution delivery device 31 is pulled up to the fourth position, the drug solution 50 sucked from the first container 32 is at least in the first delivery pipe. 34 to the third delivery pipe 36 side, even if not all of the chemical solution 50 is stored in the first region 13A of the chemical solution delivery device 31, a predetermined amount of the chemical solution 50 can be delivered to the second container 33. is possible. That is, even if most or all of the aspirated liquid medicine 50 is stored inside the third delivery pipe 36, after going through the second liquid feeding step of turning the first container 32 upside down, the flow path is switched. By pushing down the piston 3 from the fourth position to the third position, a predetermined amount of the chemical liquid 50 can be delivered to the second container 33 .

Furthermore, according to another method when the inside of the delivery tube is filled with air, the piston 3 of the drug delivery device 31 is moved from the third position to the position between the third and fourth positions. A predetermined amount of the chemical solution 50 can also be sucked by pulling it up to a fifth position provided on the . At this time, the drug solution 50 sucked from the first container 32 may reach the first region 13A of the drug solution delivery device 31 and be stored inside the first delivery pipe 34 or the third delivery pipe 36. good too.

After the piston 3 of the chemical solution delivery device 31 is pulled up to the fifth position, the surplus of the chemical solution 50 stored inside these delivery pipes is transferred to the first After returning to the container 32, the piston 3 of the drug solution delivery device 31 is pulled up from the fifth position to the fourth position. As a result, all of the drug solution 50 stored inside the first delivery pipe 34 or the third delivery pipe 36 is sucked into the first region 13A of the drug solution delivery device 31, or is stored in at least the first delivery pipe 34. The liquid medicine 50 is sucked into the first region 13A and the third delivery pipe 36 of the liquid medicine delivery device 31 . After that, by switching the flow path and pushing down the piston 3 of the chemical liquid delivery device 31 from the fourth position to the fifth position, a predetermined amount of the chemical liquid 50 can be delivered to the second container 33 .

In the fifth embodiment, the delivery pipes such as the first delivery pipe 34, the second delivery pipe 35 and the third delivery pipe 36, and the containers such as the first container 32 and the second container 33 are easily disposable. It is desirable to be made of resin. This also applies to the following modified examples.

(c) Modified example (1) of the fifth embodiment
Although the present embodiment has been described on the premise of the first container 32 and the second container 33 , the second container 33 is not essential, and the liquid medicine delivery device from the first container 32 to the second delivery pipe 35 A predetermined amount of the chemical liquid 50 sucked by the device 31 may be fed. This is because the present embodiment is not necessarily limited to storing the liquid medicine in another container.

For example, FIG. 12 shows a schematic diagram of a chemical solution delivery system 30A according to the modified example (1). As described above, in the present liquid transfer system 30A, the liquid medicine 50 sucked by the liquid medicine liquid transfer device 31 from the first container 32 storing the liquid medicine 50 and serving as the liquid transfer source is transferred to the second delivery pipe 35. Container 33 is not connected. In this case, by receiving a predetermined amount of the liquid medicine 50 flowing out from the distal end portion 35A of the second delivery pipe 35 with individual receptacles, small bags, or the like, the liquid medicine 50 can be sequentially stored in a plurality of containers. Moreover, it is good also as a usage method which does not receive with a container.

(d) Modified example (2) of the fifth embodiment
Furthermore, a further modification (2) as described below may be adopted for the fifth embodiment. FIG. 13 shows a schematic diagram of a chemical solution delivery system 30B according to the modification. The difference from the fifth embodiment of this liquid transfer system 30B is that the first container 32, which stores the chemical liquid 50 and serves as a liquid transfer source, has two openings on the top surface 41 in addition to the bottom surface 39 as inflow and outflow ports for the chemical liquid 50. was established. The fourth distribution pipe 37 connected to the top surface 41 side is connected to the first distribution pipe 34 connected to the bottom surface 39 side via the second flow path switching portion 38B. It is also connected to the second distribution pipe 35 and the third distribution pipe 36 via the first flow path switching portion 38A. Although both the first flow path switching section 38A and the second flow path switching section 38B are three-way stopcocks, they may be Y-shaped pipes without a switching mechanism, as described above.

In the case of this modified example, first, the connection of the fourth delivery pipe 37 is cut off, and the second flow path switching portion 38B is switched and connected so as to secure the flow path between the first container 32 and the chemical solution delivery device 31. . Further, the first flow path switching portion 38A is switched and connected so as to secure the flow paths of the first distribution pipe 34 and the third distribution pipe 36 . Then, by pulling up the piston 3 of the second liquid feeding part 17 of the liquid medicine liquid feeding device 31 until it reaches the fourth position, the first delivery pipe 34, the second Via the channel switching portion 38B, the first distribution pipe 34, the first channel switching portion 38A, and the third distribution pipe 36, the A predetermined amount of the chemical solution 50 can be sucked. This is referred to as the first liquid feeding step. It goes without saying that the piston 3 may be pulled up to the fifth position in the middle, as in the fifth embodiment.

Next, without inverting the first container 32 upside down as in the fifth embodiment, the connection with the first distribution pipe 34 connected to the bottom surface 39 of the first container 32 is cut off, and the fourth distribution pipe 37 and the fourth distribution pipe 37 are disconnected. The second channel switching portion 38B is switched and connected so that the channel with the No. 3 delivery pipe 36 is secured. Further, the position of the liquid medicine delivery device 31 is raised and moved from the original lowered position 44 to the raised position 45 . As for the raised position 45 , it is preferable that the lower end of the first liquid feeding part 16 of the liquid medicine liquid feeding device 31 , that is, the height of the nozzle part 7</b>A is equal to or higher than the height of the top surface 41 of the first container 32 . The liquid level of the liquid medicine 50 inside the first container 32 is reliably set at a position lower than the liquid level of the liquid medicine 50 in the first liquid feeding portion of the liquid medicine liquid feeding device 31, so that the liquid medicine 50 that has entered excessively can be removed. It is because it can return to the 1st container 32 favorably.

As a result, as in the fifth embodiment, since the liquid level of the liquid medicine 50 is arranged at a position higher than the liquid medicine delivery device 31, the surplus liquid medicine 50 that has been excessively sucked is returned to the third delivery device again. Backflow through tube 36 and fourth delivery tube 37 back to the first container. This is referred to as a second liquid feeding step.

Next, the setting of the first flow path switching unit 38A is switched so that the first distribution pipe 34 and the third distribution pipe 36 are disconnected and the third distribution pipe 36 and the second distribution pipe 35 are connected. Then, by pushing the piston 3 of the second liquid feeding portion 17 of the chemical liquid feeding device 31 downward, the piston 3 moves from the fourth position to the third position and stops. At the third position, the gasket 4 at the tip of the piston 3 is in contact with the restricting portion 5 fixed inside the second cylinder 2B of the second liquid feeding portion 17 . By this operation, a predetermined amount of the chemical liquid 50 sucked and stored inside the first cylinder 2A of the first liquid feeding section 16 of the chemical liquid feeding device 31 is transferred to the third delivery pipe 36, the first flow path switching section 38A and the It is discharged into the interior of the second container 33 from the bottom surface 40 at the lower end of the second container 33 via the second delivery pipe 35 . This is referred to as a third liquid feeding step.

Through the above steps, as in the fifth embodiment, a predetermined amount of the chemical solution 50 stored in the first container 32 is temporarily sucked by the chemical solution delivery device 31, and the second container, which is a separate container, is 33. Also, the risk of foreign matter such as silicone oil eluting into the chemical solution 50 can be reduced. Also in this modification, as in modification (1), the configuration of the second container 33 is not essential, and any configuration that allows a predetermined amount of the liquid medicine 50 to be transferred to the second delivery pipe 35 is sufficient.

EXAMPLES Next, the present disclosure will be described in more detail with examples, but the present disclosure is not limited to these examples.

A commercially available 1000 ml infusion bag made of a flexible resin material was used as the first container containing the drug solution to be transferred. CryoMACS (registered trademark) Freezing Bag 50 manufactured by Miltenvi Biotec was used as the second container. Water was used as the chemical solution, and 2 ml of the solution was fed. As a chemical liquid delivery device, a nozzle of Terumo Corporation's syringe (20 ml, model: SS-20LZ) is fixed to a vent filter of a Corning closed system centrifuge tube (for 50 ml, filter pore size 0.2 μm). was used. In addition, a PVC tube with an inner diameter of 3 mm and a C-FLEX tube were used as delivery tubes for connecting each device. The distance of the delivery pipe from the first container to the drug delivery device via the manually switching three-way stopcock is set to 90 cm, and the distance of the delivery pipe from the second container to the drug delivery device via the three-way stopcock is set to 90 cm. and

As for the liquid delivery method, the liquid delivery method of the chemical solution of the fifth embodiment was performed using the liquid chemical delivery device of the fourth embodiment. A state in which the inside of each delivery pipe is filled with air is defined as an initial state. First, the first container is arranged so that the discharge port (bottom surface) faces downward, the three-way stopcock is switched so that the first container and the first liquid feeding part of the chemical liquid feeding device are connected, and the second feeding The piston of the liquid part was pulled from the third position, which is the pushing limit position, to a position indicating 2 ml before reaching the fourth position, which is the lifting limit position (corresponding to the above-mentioned fifth position). As a result, a predetermined amount of liquid medicine was sucked from the first container in the direction of the first liquid feeding part of the liquid medicine feeding device. After that, the first container is turned upside down and the discharge port (bottom surface) is directed upward to lower the water level of the first container and release the water pressure. and returned into the first container (corresponding to the above-described second liquid feeding step).

After that, by further pulling up the piston toward the fourth position, all the liquid medicine remaining in the delivery pipe was sucked into the first liquid feeding section. At this time, the liquid was sent by pushing out the liquid chemical with the air in the first container. After that, the three-way stopcock was switched so that the second container and the first liquid feeding section of the liquid medicine liquid feeding device were connected, and the piston of the second liquid feeding section was pushed from the above-mentioned raised position to the third position. As a result, all of the liquid medicine sucked into the first liquid feeding part of the liquid medicine liquid feeding device is discharged toward the second container, and the same amount of the liquid medicine as that sucked from the first container is discharged by the liquid medicine liquid feeding device. It was possible to accurately transfer the prescribed amount of liquid to the second container.

Further, here, when the amount of the chemical solution contained in the first container was 500 ml and when the amount of the chemical solution was 100 ml, the liquid was sent three times each. They were 1.964 ml and 1.967 ml, respectively, and there was little change in both. On the other hand, as a comparative example, when the amount of the chemical solution contained in the first container is 500 ml and 100 ml, the first container is turned upside down, the water level in the first container is lowered, and the water pressure is increased. When the liquid was fed three times each without performing the operation of the second liquid feeding step of releasing, the average actual liquid feeding amounts were 2.04 ml and 1.931 ml, respectively. As a result, the amount of liquid sent varies depending on the amount of chemical liquid used. From this, after a predetermined amount of the chemical solution is sucked from the first container toward the chemical solution delivery device, the first container is turned upside down to lower the water level of the first container and release the water pressure. By performing the above operation, fluctuations in the amount of suction due to changes in liquid pressure caused by the original amount of liquid medicine in the first container are corrected, and regardless of the amount of liquid medicine in the first container, a predetermined amount of liquid medicine is stably delivered. It was confirmed that liquid was produced.

1, 1A, 1B, 1C Chemical liquid delivery device 2 Cylinder 2A First cylinder 2B Second cylinder 3, 3A Piston 4 Gasket 5, 5A, 5B, 5C, 5D, 5E, 5F Regulating part 6 Piston tip part 7, 7A Nozzle Portion 7B Second connection portion 7C Ends 8, 9 Cylinder openings 8A, 9A Inner protrusion inner surfaces 8B, 9B Inner protrusion outer surface 9C First connection portions 11, 11A First inner surfaces 12, 12A Second inner surfaces 13, 13A First regions 14, 14A Second regions 15, 15A, 15B Connecting pipe 16 First liquid sending part 17 Second liquid sending part 21 Ring part 22 Opening 23 Concave part 24 Convex part 25 Projection 26 Membrane member 27 Opening 28 Filter 30, 30A, 30B liquid delivery system 31 chemical liquid delivery device 32, 32A first container 33 second container 34 first delivery pipe 35 second delivery pipe 35A tip portion 36 third delivery pipe 37 fourth delivery pipe 38 flow switching portion 38A First flow switching portion 38B Second flow switching portion 39 Bottom surface 40 Bottom surface 41 Top surface 42 First container position 43 Second container position 44 Down position 45 Up position 50 Chemical solution 60 Filter unit 61 Filter 62 Filter case 63 Third connection Part 64 fourth connection part

Claims (3)

A first liquid feeding section comprising a first cylinder having a nozzle section with a hole at one end and a first connecting section with a hole at the other end;
A second cylinder having a second connection portion with a hole at one end and an opening at the other end and a gasket at the tip thereof are slid along the inner surface of the second cylinder via the gasket. a second liquid feed section having a piston capable of
a connecting pipe that connects the first connecting portion of the first liquid feeding portion and the second connecting portion of the second liquid feeding portion;
A restricting portion that restricts a sliding range of the piston from the opening toward the second connecting portion is formed in either the second cylinder or the piston ,
When the position of the piston closest to the second connecting portion side in the sliding range is the third position, and the position of the piston farthest from the second connecting portion side is the fourth position,
The internal volume of the first cylinder, the connecting pipe, and the second cylinder from the one end of the first liquid feeding portion to the end surface of the gasket of the piston at the fourth position is the third The volume of the inside of the first cylinder, the connecting pipe, and the second cylinder from the one end of the first liquid feeding part to the end surface of the gasket of the piston at the position of is twice or less the chemical solution Liquid transfer device. A first liquid feeding section comprising a first cylinder having a nozzle section with a hole at one end and a first connecting section with a hole at the other end;
A second cylinder having a second connection portion with a hole at one end and an opening at the other end, and a gasket at the tip thereof along the inner surface of the second cylinder through the gasket to a certain sliding range. A second liquid feeding unit having a piston that can be slid with, and
a connecting pipe that connects the first connecting portion of the first liquid feeding portion and the second connecting portion of the second liquid feeding portion;
The connecting pipe is provided with a filter for removing a predetermined foreign matter when the piston of the second liquid feeding section is slid to transfer the gas inside the second liquid feeding section to the first liquid feeding section. placed and
When the position of the piston closest to the second connecting portion side in the sliding range is the third position, and the position of the piston farthest from the second connecting portion side is the fourth position,
The internal volume of the first cylinder, the connecting pipe, and the second cylinder from the one end of the first liquid feeding portion to the end surface of the gasket of the piston at the fourth position is the third The volume of the inside of the first cylinder, the connecting pipe, and the second cylinder from the one end of the first liquid feeding part to the end surface of the gasket of the piston at the position of is twice or less the chemical solution Liquid transfer device. A chemical liquid feeding method for feeding a predetermined amount of a chemical liquid from a first container containing the chemical liquid to a second container different from the first container,
A chemical liquid delivery device preparation step of preparing the chemical liquid delivery device according to claim 1 or 2 ,
A first container containing a chemical solution and the chemical solution delivery device are connected by a delivery pipe via a channel switching part, and the chemical solution can be transferred only between the first container and the chemical solution delivery device. A delivery pipe connection step in which either a first flow path or a second flow path capable of transferring the liquid medicine only between the liquid medicine delivery device and the second container can be selected. ,
When the position of the piston closest to the second connecting portion side in the sliding range is the third position, and the position of the piston farthest from the second connecting portion side is the fourth position, selecting a first flow path, and sliding the piston of the drug delivery device from a predetermined position between the third position and the fourth position toward the fourth position by a predetermined distance; a first liquid feeding step of feeding a predetermined amount of the chemical liquid toward the first liquid feeding portion of the chemical liquid feeding device through the delivery pipe connected to the lower end of the first container,
After the first liquid feeding step, the arrangement of the first container is changed so that the liquid level of the chemical liquid in the first container is lowered, and the surplus liquid fed to the first liquid feeding unit is a second liquid feeding step of returning the chemical liquid to the first container; and
After the second liquid feeding step, the second flow path is selected, and the piston of the medical liquid feeding device is slid from the predetermined distance toward the third position. a third liquid feeding step of feeding a predetermined amount of the chemical liquid to the second container by causing the liquid chemical to flow into the second container.

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