JP7269158B2 - Container for consumables coated with resveratrol-containing layer - Google Patents

Description

TECHNICAL FIELD The present invention relates to a container comprising a resveratrol-containing layer, particularly towards the inside of the container. The container will in particular be filled with consumables, in particular foods or foodstuffs, personal care or pharmaceutical products. The container in particular has an inner coating layer containing resveratrol. The invention further relates to methods of making such containers, the use of such containers for the storage of consumables, and the use of resveratrol as an additive to the coating layer of such containers.

BACKGROUND OF THE INVENTION Consumables have been stored for centuries in a variety of containers including wood, animal skins, pottery and leather.

Alternative forms of packaging, such as metal containers, plastic containers such as those made of polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET) or other polymers and mixtures thereof, and paper or cardboard containers have emerged in the last decade. Demand is growing. While they offer the advantage of being lighter in weight, their properties are often unsuitable for long-term storage, especially of oxidation-sensitive products.

Such oxidation-sensitive products are relevant to all areas of consumables, especially foodstuffs, such as food and beverages, but also pharmaceutical or drug products, medical and veterinary formulations, and cosmetic and personal care products. There is In many cases, problems also arise from the relatively invasive nature of the commodity or product. These problems arise with both liquid and solid consumables. As a result of interactions between the product and the container or compounds entering the container (eg oxygen), the quality of the product is compromised and/or the shelf life and storage stability of the consumable is reduced.

To ensure product integrity, longevity, and meet consumer demand for sustainable packaging and requirements for preserving product quality under a variety of global storage and transportation conditions, It is considered desirable to develop a robust packaging system, especially for delicate products (consumables).

With globalization and increasing world market demand for consumables, there is a need to transport those goods globally while maintaining their integrity and stability.

Moreover, in today's global economy, consumable producers are forced to package their products in many countries around the world. These products are susceptible to a variety of local conditions during manufacture, including water quality and chemical content, weather conditions, etc., all of which have significant potential to affect product integrity, stability and longevity. have a nature.

Essentially the same or similar factors apply to producers of all consumables, such as food or cosmetics, health care or beauty products, pharmaceutical products, drugs, and the like. SUMMARY OF THE INVENTION It is therefore an object of the present invention to provide an advantageous container, especially for consumables such as food or foodstuffs, personal care products or pharmaceutical products, and to avoid the above-mentioned prior art problems.

Yet another object of the invention is to provide a method for manufacturing such a container and the use of such a container.

SUMMARY OF THE INVENTION According to one aspect of the present invention, there is provided a container, particularly for consumables, wherein the inner surface of the container is at least partially coated with a coating layer containing resveratrol.

According to its broader aspects, the invention relates to a container comprising a resveratrol-containing layer, particularly towards the inside of the container. The container will in particular be filled with consumables, in particular foods or foodstuffs, personal care or pharmaceutical products. The container in particular has an inner coating layer containing resveratrol.

In one embodiment of the invention, the container does not (yet) contain consumables. Accordingly, one aspect of the present invention refers to containers manufactured prior to being filled with consumables. According to one aspect of the present invention, a consumable (or consumable) is an item that can be consumed (according to Webster's Dictionary, 1913 Edition). Consumed is used in any way, e.g., as a food product for nutrition, for personal care or health or beauty purposes, for pharmaceutical or veterinary purposes, or in any other way. or used.

According to one embodiment of the present invention, the consumables are inter alia foodstuffs such as food products, food ingredients, nutrients, nutraceuticals, beverages, as well as cosmetics, beauty and health care products, pharmaceutical and veterinary products, pharmaceuticals, etc. is understood to include In general, articles may include solid, liquid and/or gaseous components. Foodstuffs, according to one embodiment, are understood as those which are edible for humans or animals, ie suitable for eating. A non-limiting list of preferred foods or food ingredients are solid foods, liquid or liquid foods, such as both foods, baby foods, (baby) formula powders, foods in solids, such as canned foods, Includes ready-to-eat meals or dishes such as canned fish, semi-solid foods such as meats, fruits or vegetables in juices or sauces, other food products or condiments, sauces, marinades, spices, and the like. A non-limiting list of preferred pharmaceutical or veterinary products are medicaments in forms such as tablets, capsules, granules, powders, liquids and other solid or liquid dosage forms. A non-limiting list of preferred cosmetic or beauty and health care products include creams, lotions, soaps, emulsions, dispersions or liquids and the like.

As used herein, "container" shall be broadly understood to include all types of rigid or flexible containers or packaging (for consumables).

In one embodiment of the invention, said consumable is a non-beverage consumable.

In one embodiment of the invention said consumable is a food or grocery, personal care or pharmaceutical product.

In one embodiment of the invention said personal care or pharmaceutical product is in the form of tablets, capsules, granules, powders, liquids, soaps, lotions or creams, emulsions, dispersions or solutions and the like.

In another preferred embodiment, the entire inner surface of the container is covered with a resveratrol-containing coating layer.

In yet another preferred embodiment, said coating layer comprises at least 0.0001 wt% resveratrol, preferably at least 0.001 wt%, more preferably at least 0.01 wt%, even more preferably at least 0 .1% by weight, even more preferably at a concentration of at least 1.0% by weight.

In yet another preferred embodiment, said coating layer comprises at most 30 wt% resveratrol, preferably at most 10 wt%, more preferably at most 1 wt%, even more preferably at most 0.1 wt%. % by weight, even more preferably at a concentration of at most 0.01% by weight.

In yet another preferred embodiment, said container is made of glass, metal, polymeric material, paper, cardboard, or combinations thereof, in a more preferred embodiment, aluminum.

In yet another preferred embodiment, the thickness of the coating layer on the inner surface of said container is in the range of about 3.5 to about 8.4 g/m ² , in a more preferred embodiment about 4.0 to about 8 g/m 2 . .0 g/m ² , and in the most preferred embodiments from about 5.0 to about 8.0 g/m ² . In another embodiment, the thickness of the coating layer and/or the container wall can be about 0.1 μm to 10 mm, especially about 1 μm to 1 mm.

In another preferred embodiment, the coating layer does not contain epoxy resin, and in a more preferred embodiment, the coating layer does not contain bisphenol A or bisphenol A releasing substances.

In yet another preferred embodiment, said coating layer is a thermosetting coating layer.

In yet another preferred embodiment, at least one additional coating layer is present within the container, optionally between the resveratrol-containing coating layer and the metallic container wall.

According to a further aspect of the invention there is provided a method for manufacturing a container for consumables as defined above, said method comprising the steps of:
a) providing a container having a container wall with an inner surface facing the interior space of the container;
b) providing a resveratrol-containing coating layer on the inner surface of the container wall;
including.

According to one embodiment, step b) of the above method comprises applying an uncured coating layer containing resveratrol to the surface of said container wall material; and curing said uncured coating layer. .

In one embodiment of the method, an uncured coating layer containing resveratrol is applied to the surface of the container wall material before the container is formed.

In another embodiment of the method, an uncured coating layer containing resveratrol is applied to the surface of the container wall material after the container is formed.

In yet another embodiment, the method includes the additional step of filling the container with a consumable as defined herein.

In further embodiments, the consumable is a food or grocery, personal care or pharmaceutical product.

According to a further aspect of the invention there is provided a container obtainable by the method of the invention.

Another further aspect of the invention relates to a container according to any one of the above aspects or embodiments, further comprising consumables, in particular non-beverage consumables. In particular, a further aspect of the invention relates to a container according to any one of the above aspects or embodiments, further comprising or being filled with consumables, eg non-beverage consumables.

According to a further aspect of the invention there is provided use of a container according to any one of the above aspects or embodiments of the invention for the storage of consumables, in particular non-beverage consumables. According to a further aspect of the invention there is provided the use of resveratrol as an additive to a coating layer on the inner surface of a container for consumables, especially non-beverage consumables.

According to a preferred embodiment, said consumables are food or groceries, personal care or pharmaceutical products.

All embodiments and aspects described and/or stated herein are considered combinable within the invention unless this is excluded by contradiction. In particular, embodiments of features relating to containers or materials and consumables thereof are combinable and disclosed in any combination with any product, method or mode of use of the present invention.

DETAILED DESCRIPTION OF THE INVENTION A container for a consumable is provided between the consumable and the packaging material, or between the consumable and the container, wherein the inner surface of the container is at least partially coated with a coating layer containing resveratrol. It has now been surprisingly found that the product provides excellent protection from harmful and undesired degradation, including the undesired consequences of reactions with compounds that enter or are present within the.

As noted above, according to one embodiment of the present invention, consumables are food products, food ingredients, nutrients, dietary supplements, beverages, cosmetics, beauty and health care products, pharmaceutical and veterinary products, drugs, among others. is understood to include In general, articles may include solid, liquid and/or gaseous components. A non-limiting list of preferred beverages includes wine or wine-based products, soft drinks, fruit juices, milk or whey-based beverages, and the like. A non-limiting list of preferred foods or food ingredients are solid foods, liquid or liquid foods, e.g. both foods, baby foods, (baby) formulas, etc., foods in solids, e.g. canned foods, cooked meals. or foods, such as canned fish, semi-solid foods such as meat, fruit or vegetables in juices or sauces, other food products or condiments, sauces, marinades, spices, and the like. A non-limiting list of preferred pharmaceutical or veterinary products are medicaments in forms such as tablets, capsules, granules, powders, liquids and other solid or liquid dosage forms. A non-limiting list of preferred cosmetic, beauty and health care products include creams, lotions, soaps, emulsions, dispersions or liquids and the like. Also included are personal care products or toiletries, ie articles used for personal hygiene and beautification. Personal care products include, but are not limited to, lip balms, cleansing pads, colognes, deodorants, eyeliners, lip glosses, lipsticks, lotions, makeup, pomades, perfumes, talc powders, shaving creams, skin creams, wet wipes, etc. including. Also included are drugs and drug-containing compositions (pharmaceuticals and veterinary products). A drug, in its broadest sense, is a chemical substance that has a known biological effect in humans or other animals.

According to one embodiment of the invention, said consumable is a beverage, in particular wine or a wine-based beverage. As used herein, wine is understood to include any beverage obtained from viticultural and winemaking techniques known in the art. In one preferred embodiment, the wine is red wine. In another preferred embodiment the wine is white wine. In yet another preferred embodiment the wine is rosé wine. The wine may be still wine or carbonated sparkling wine. The wine may also be fortified wine. Wine-based beverages are understood to include any beverage containing wine as defined above. Wines blended with mineral water or fruit juices can be mentioned as examples of wine-based beverages.

As used herein, "container" shall be broadly understood to include all types of rigid or flexible containers or packaging (for consumables).

Furthermore, containers with coatings containing resveratrol surprisingly effectively prevent or minimize deterioration of packaged consumables, particularly due to oxidation. Resveratrol is also present in grape skins. Resveratrol is found in wine (grapes) in cis- as well as trans-configurations. As used herein, the term resveratrol should be understood in its broadest form. In one embodiment, resveratrol includes cis-resveratrol as well as trans-resveratrol. In a preferred embodiment resveratrol should mean trans-resveratrol.

Surprisingly, the container according to the invention helps to maintain and even improve the quality and/or longevity of consumables. Surprisingly, the inventors have found that the use of resveratrol in the container of the present invention not only allows protection of the consumable from the container material, but also enhances the beneficial effects on the consumable. I discovered that Without being bound by this theory, resveratrol is involved in beneficial interactions between the container (inner surface) and the consumable, and may also be present on the surface of the container wall with potentially harmful substances such as oxygen, etc. can neutralize or replace oxidants or aggressive substances of

The present invention is directed to interactions between the packaging material, or compounds present in the container, such as air or, in particular, oxygen, which lead to deterioration and decomposition of the packaging material and/or the packaged article and ultimately to damage of the consumable. Useful for packaging any consumable that can act or react.

Surprisingly, the inventors have found that the use of resveratrol as a component of a coating system within the container not only provides protection for beverages such as wine from container materials, It has been found to enhance beneficial effects.

In the context of packaging invasive beverages that are difficult to hold, such as wine, there is a risk that the beverage will interact and react with the packaging material, which can affect the taste, appearance or overall integrity of the beverage. This interaction is primarily caused by acids or free radicals that are either originally present in the beverage or generated over time.

Accordingly, the present invention is not limited to wine or wine-based beverages as beverages, which may interact or react with the packaging material leading to deterioration and decomposition of the packaging material and, ultimately, spoilage of the beverage. Also useful for packaging any beverage. Examples of such beverages are fruit juices, especially grape juices, soft drinks, lemonades, colas, acidic drinks, carbonated drinks and drinks containing phosphoric acid.

In general, the problem of damage to the consumable by the packaging material arises when the consumable reacts with the inner coating of the container, making it important to prevent deterioration and degradation of the packaging material.

Surprisingly, the inventors have discovered that resveratrol as part of the coating on the inner wall of the container can protect and prevent this deterioration and degradation. While not wishing to be bound by theory, according to one embodiment of the present invention, resveratrol present in the coating of the container, at the surface of the coating facing and in contact with the consumable, And it is envisioned that it can function as an active ingredient in the coating (which can also act as a long-term releasable reservoir of resveratrol) and in the consumable when transitioning from the coating to the consumable. be.

It has been observed that resveratrol may have additional desirable functions as part of the present invention, such as inhibiting undesired reactions or deterioration of consumables in containers. Thus, for example, overgrowth of microorganisms can lead to deterioration of the taste, aroma and integrity of foodstuffs. In addition, microbial metabolites can exacerbate the problem of packaging breakage.

By creating a kind of barrier with the positive effects of resveratrol, the inventors have surprisingly found that it protects the consumable and enhances the stability and longevity of the consumable.

According to one aspect of the invention, resveratrol is advantageously present in the coating of the container prior to adding the consumable to the container. According to this embodiment, the container of the invention refers to an empty container before filling with consumables. According to one embodiment, the container of the present invention is a fresh container, i.e. not previously used for filling consumables. Thus, a barrier having the protective function described above is provided along the inner wall of the container, avoiding aggressive, corrosive, acidic and oxidizing components of e.g. At this point, it provides a protective and beneficial surface for the coating. According to one embodiment of the present invention, this initial protection is particularly important to keep the coating layer intact from initial contact with the consumable, but may also protect the long-term quality and excellence of the consumable. be.

In a preferred embodiment of the invention, said coating layer comprises at least 0.0001 wt% resveratrol, preferably at least 0.001 wt%, more preferably at least 0.01 wt%, even more preferably at least 0 .1 wt%, even more preferably at least 1 wt%, even more preferably at least 10 wt%, even more preferably at least 30 wt%.

In another preferred embodiment of the invention, said coating layer comprises at most 70% by weight resveratrol, preferably at most 30% by weight, more preferably at most 10% by weight, even more preferably at most 1% by weight. % by weight, even more preferably at most 0.1% by weight, even more preferably at most 0.01% by weight, even more preferably at most 0.001% by weight.

In a particularly preferred embodiment of the invention, the coating layer according to the invention contains resveratrol from 0.0001 to 10% by weight, in one more preferred embodiment from 0.1 to 5% by weight, preferably from 0.5% by weight. to 1 wt%, in another more preferred embodiment from 0.001 to 0.05 wt%, preferably from 0.005 to 0.01 wt%.

According to one embodiment of the present invention, the above weight percent ranges are based on the total weight of the coating layer containing resveratrol. When more than one coating layer is present in the container, the above weight percent ranges are based on the total weight of all coating layers, according to one embodiment of the invention. According to another embodiment of the present invention, the above weight percent ranges are based on the total weight of the resveratrol-containing coating layer only.

According to one aspect of the invention, the concentration of resveratrol may also vary across the cross-section of the coating layer. For example, according to one embodiment, the concentration of resveratrol at or near the surface of the coating layer facing the consumable may be higher than in portions of the coating further away from that surface. Thus, the protective effect of the coating layer on the surface is improved according to an embodiment of the invention, for example in a virgin container before being filled with a consumable, and thus when the consumable is filled into the container. An advantageous protective layer is present. According to another embodiment, an opposite concentration profile may be preset, providing a longer lasting reservoir of resveratrol in the coating layer.

The container of the present invention provides consumable producers and packers with an improved method of packaging their goods.

The resveratrol-containing internal barrier and its method of application can be part of an overall packaging system that has the potential to be applied to any container during the normal container manufacturing process.

Furthermore, the container according to the invention allows shipping the finished product, including sensitive consumables, in non-refrigerated sea containers, thus minimizing the carbon footprint.

In preferred embodiments, the container comprises or consists of metal, polymeric material such as plastic material, paper, cardboard, glass or a combination thereof, in a more preferred embodiment aluminum. The present invention is useful for preserving any consumables described herein, and consumables that are acidic, corrosive, oxidizing, or capable of reacting in any way with packaging materials and environments. Contains consumables that are sensitive to factors and compounds present in the container. As noted above, the term container, as used herein, includes any packaging or packaging material for rigid or flexible consumables. The container may have any suitable form or shape for packaging the respective item. Such containers may be, for example, without limitation, cans, bags, tins, canisters, tanks, bowls, flasks, casks, and the like. According to one embodiment, the container is a packaging for a medicament. According to one embodiment, the container may also be in the form of a blister pack, optionally present on metal and/or plastic foil of the blister pack.

In a preferred embodiment of the invention, said coating layer acts as a two-way barrier. A two-way barrier, in the context of the present invention, should be understood not only to protect the consumable from undesirable interactions with the packaging material that result in degradation or alteration of the quality of the consumable. In addition, the barrier should also protect the packaging material from undesired interactions with consumables that could potentially damage the container or the integrity of the container.

According to some aspects of the invention, the containers, methods and uses of the invention may inter alia reduce the potential for food poisoning (particularly from canned foods) or improve product shelf life (product life and stability). ) can be extended. They also help achieve a variety of shipping conditions suitable for packaged consumables over several global climatic conditions. They may further reduce the need for preservatives, such as salt/sodium based preservatives, or sorbic acid as a preservative, for example in canned foods. They can also prevent harmful corrosive effects, for example on the container or its lining. In many cases they can maintain or stabilize the natural flavor profile or enhance the natural flavor of consumable foodstuffs. Formation of free radicals can be reduced, for example, by achieving a reduction/elimination of unwanted bacterial formation in food. As a result, the likelihood of infection may be reduced. For pharmaceutical products, stability and quality can be improved.

According to one embodiment, in principle all coating compositions or lacquers known to the person skilled in the art can be used within the invention for the coating layer(s). Examples of general methods for the preparation and application of exemplary layers can be found in EP 2 457 840 A1, "Packaging Materials 7. Metal Packaging for Foodstuffs", published by ILSI Europe Packaging Materials Task Force, 2007. September, https://europa.eu/sinapse/sinapse/index.cfm?fuseaction=lib.attachment&lib id=C5C03DA0-EP72-0D54-309D55AA14F6C62F&attach=LIB DOC EN) or "Preliminary Industry Characterization: Metal Can Manufacturing-Surface Coating", published by the U.S. Environmental Protection Agency, September 1998, accessible at http://www.epa.gov/ttnatw01/coat/mcan/pic-can.pdf). ing.

Coating compositions and layers for metallic and non-metallic surfaces are known to those skilled in the art. The composition is selected by those skilled in the art with regard to surface properties and adhesion to metallic or non-metallic surfaces and compatibility with consumables to be packaged. Preferred non-metallic materials (surfaces) for application of the resveratrol-containing layer are polymeric or plastic surfaces. Resveratrol can be easily added before, during or after formation of the layer.

Lacquers previously used for the inner coating (coating layer) of containers, such as aluminum cans, were mainly based on bisphenol A (BPA)-containing compounds, such as epoxy resins. According to one embodiment of the invention, the use of bisphenol A or bisphenol A releasing materials in the coating layer of the beverage container is avoided. According to certain embodiments, the coating layer should not contain any of the following potentially hazardous substances: formalin, potassium permanganate (KMnO4), dibutyl phthalate (DBP), bis(2-ethylhexyl). Phthalate (DEHP), diisobutyl phthalate (DIBP), dimethyl phthalate (DMP), diethyl phthalate (DEP), bis(2-ethylhexyl) adipate (DEHA), diisodecyl phthalate (DIDP), diisononyl phthalate (DINP).

In another embodiment the lacquer is free of epoxy resins and in a further embodiment the coating layer is free of bisphenol A or bisphenol A releasing substances.

In another preferred embodiment, said coating layer is a thermosetting coating layer.

In a preferred embodiment, the lacquer according to the invention meets all USFDA regulations or food safety regulations of other countries, in particular the lacquer is food grade. Such lacquers are known to those skilled in the art and commercially available. All available lacquers can be used within the present invention.

The thickness of the coating layer of the container according to the invention preferably prevents aggressive ingredients in the consumable from coming into contact with the container material and provides sufficient protection for the article in which it is to be packaged. should be selected as such. The present invention provides extended shelf life and enhanced product integrity.

In preferred embodiments, the thickness of the coating layer on the inner surface of the container is within the range of about 3.5 to about 8.4 g/m ² , and in more preferred embodiments from about 4.0 to about 8.0 g/m 2 . ² , and in the most preferred embodiment from about 5.0 to about 8.0 g/m ² . In another embodiment, the thickness of the coating layer and/or the container wall can be about 0.1 μm to 10 mm, especially about 1 μm to 1 mm.

In one preferred embodiment, the coating layer is distributed throughout the inner wall of the container such that the entire inner wall is coated with the resveratrol-containing layer.

In another preferred embodiment, the resveratrol-containing coating layer is an impermeable layer, i.e. the resveratrol-containing coating layer is impermeable to the consumable, and the interaction between the packaging material and the consumable is prevent action.

According to one embodiment of the invention, the walls of the container for consumables may comprise one or more layers. If the wall of the container consists of only one layer, according to one embodiment of the invention, this one layer, ie the wall of the container, may comprise resveratrol. In other words, the coating layer is then the wall of the container. An example of such an embodiment of the present invention is a layer of plastic foil sealed together to form a sort of bag for consumables, such as ready-to-use meals. It is a container consisting of The wall of the container, ie one layer of plastic foil, then contains resveratrol and is at the same time the wall of the container.

According to a preferred embodiment of the present invention, the layer containing resveratrol (eg the coating layer or the wall of the container) is a layer comprising or substantially or completely consisting of a polymer. Particularly preferred are polymers with functional groups, preferably their OH groups, that allow interaction with resveratrol. Non-limiting examples of such polymers are those with functional groups capable of forming hydrogen bonds with resveratrol. Preferred examples of polymers suitable according to the invention are polymers containing functional groups with O, N, S, Cl or F heteroatoms.

According to one preferred embodiment, all, substantially all or at least part of the resveratrol contained in a layer (e.g. coating layer, or container wall) is present in a component of the layer, in particular in the layer Not covalently attached to the polymer. Non-covalently bound resveratrol can migrate and replenish resveratrol on the inner surface of the container or in packaged consumables. On the other hand, binding and fixing at least a portion of the resveratrol to the components of the layer may, in some instances, keep the resveratrol in its preferred location, particularly in direct contact with the packaged article. may help to do so.

In yet another preferred embodiment, the inner wall is partially covered with a coating layer containing resveratrol. For example, the container may be coated with a resveratrol-containing coating layer only in those areas of the container where the coating is most likely to crack or break. Alternatively, the inner wall may be coated with spots of a coating layer containing resveratrol. These spots may provide sufficient resveratrol to provide the beneficial effects of the present invention. Areas not covered by the resveratrol-containing coating layer according to this embodiment may be covered with a different coating layer to prevent interaction between the packaging material and the consumable.

A further aspect of the invention is a method of manufacturing a container for consumables as defined above, comprising the steps of:
a) providing a container having a container wall with an inner surface facing the interior space of the container;
b) providing a resveratrol-containing coating layer on the inner surface of the container wall;
relating to the method, including

As described herein, any container suitable for providing the interior space of the container for packaging consumables can be used. The container has a container wall, the container wall having an inner surface facing the interior space of the container. Any coating layer containing resveratrol described herein or deemed suitable by one of ordinary skill in the art may be used. According to one aspect, the container may have only one layer as container wall, such that the coating layer is also the container wall. Additional layers may also be provided on the container wall.

According to one further aspect, the present invention further provides a method of manufacturing a container for consumables, comprising applying an uncured coating layer containing resveratrol to the surface of the container wall material, and A method is provided that includes curing a coating layer.

The uncured coating layer can be applied to the container wall material by, for example, standard spray application guns known in the art.

In one embodiment of the invention, an uncured coating layer containing resveratrol is applied to the surface of the container wall material before the container is formed. An advantage of this embodiment is that the uncured coating layer containing resveratrol can be applied and distributed more consistently on the surface of the container wall material before the material is formed into the hollow container. In another preferred embodiment, the resveratrol-containing coating layer is preferably in the form of a film or foil that is laminated or otherwise bonded to the container wall material before or after forming the container. It can be attached or applied to the surface of the wall material. According to one embodiment of the invention, the resveratrol-containing coating layer(s) is prepared without extensive heating for a long time, for example by using foil. Also, if curing of the layer(s) is performed, other curing methods than thermal curing may be used, or the time and temperature of heating may be limited.

In another embodiment of the invention, an uncured coating layer containing resveratrol is applied to the surface of the container wall material after the container is formed. An advantage of this embodiment is that a standard container can be obtained from a commercial manufacturer and then provided with the coating layer of the invention to obtain a container having the advantages according to the invention. Also, according to another embodiment, resveratrol may be added to the composition of at least one coating layer, otherwise the manufacturing process remains the same.

In one aspect of the invention, resveratrol, eg, a solution containing resveratrol, can be sprayed onto the inner surface of a container, including a container wall having one or more layers. In another embodiment, resveratrol is added, eg, sprayed, onto the surface of the coating layer after the coating layer has been applied to the inner wall (or surface) of the container, but before the consumable is filled into the container. According to a further embodiment, resveratrol is added to, eg sprayed onto, the coating layer after curing of the coating layer, but before the consumable is filled into the container.

In a preferred embodiment of the invention, the method includes the additional step of filling the container with the consumable. According to one embodiment, this is done after a resveratrol-containing coating layer has been provided on the inner surface of the container.

In the context of the present invention, the inner surface of the container should be understood to mean the inner surface of the container wall facing the interior of the container. Thus, a container according to the invention has a container wall, for example of metal, such as aluminium, which has an outside facing the outside of the container and an inside facing the inside of the container. Accordingly, the inner surface (or surface) of a container according to an embodiment of the invention may be coated with one or more layers, at least one of which layers contains resveratrol. In one embodiment of the invention, the inner surface (wall) of the container is provided with only one layer (coating layer). This layer contains resveratrol according to the invention. In another embodiment of the invention, the inner surface (wall) of the container provides two or more layers. In this case, one or more of the layers may contain resveratrol.

According to a broad aspect of the invention, the container thus comprises a container wall consisting of one or more layers, wherein at least one layer contains resveratrol.

According to one embodiment, one or more layers without resveratrol may be present between the layer containing resveratrol and the container wall. Also, according to one embodiment, one or more resveratrol-free layers may be present between the resveratrol-containing (coating) layer and the exterior of the container.

According to another embodiment, the one or more layers that do not contain resveratrol are present between the layer containing resveratrol and the interior of the container, i.e. in the cavity of the container where the consumable can be filled. good too. According to a further embodiment, the layer containing resveratrol is the layer directly facing the interior of the container, i.e. in direct contact with the cavity of the container or the consumable, respectively, after the container has been filled with the consumable. are doing. In one embodiment of the invention, resveratrol may be included in any of the layers located inside the outer aluminum shell (container wall) of the can. In a preferred embodiment, resveratrol can interact with the consumable either directly or via an additional layer that is permeable to resveratrol and/or the consumable. It is contained only in one or more layers located inside the outer aluminum shell. In another preferred embodiment, resveratrol is included in one layer that can interact with the consumable.

In another preferred embodiment, the uncured coating layer contains free metal radicals. The addition of free metal radicals to the uncured lacquer will reduce baking and curing temperatures as well as curing times, resulting in a further reduction in the energy required to package consumables in containers according to the invention. .

In one embodiment, the uncured coating layer is cured at a temperature of 180 to 250°C, more preferably 180 to 220°C, for 80 to 230 seconds.

According to the invention, it is possible to apply a resveratrol-containing top coating layer to the inside of the container such that the resveratrol-containing layer is in contact with the consumable.

In yet another preferred embodiment, at least one additional coating layer is present. For example, the bottom layer is a resveratrol-infused, BPA-free, anti-corrosion coating layer that specifically contains a water-based monomer enhancer that directs resveratrol to the top coating layer that is in contact with the consumable.

According to one embodiment of the invention, it is ensured that resveratrol is placed on the inner surface of the coating layer of the container in contact with the consumable at the final stage of manufacturing the container (i.e. before filling). be.

The invention also provides the use of the container described herein for storage of consumables. In preferred embodiments, the container is used for storage of non-beverage consumables.

Furthermore, the present invention provides the use of resveratrol as an additive to a coating layer, in particular a coating layer on the inner surface of a container, especially a container for consumables.

All embodiments of the present invention described herein are believed to be combinable in any combination, unless a person skilled in the art considers such a combination to make technical sense.

Example 1
Preparation of resveratrol-containing lacquer (coating layer) Bisphenol A-free polyester acrylate-containing layer (prepared according to Example 2 of WO 2008/036629 A2)
A 2-liter flask was equipped with a stirrer, packed column, condenser, thermocouple, heating mantle and nitrogen blanket. The following were added to the flask: 498.6 grams of propylene glycol, 80.1 grams of trimethylolpropane, 880.1 grams of terephthalic acid, 40.0 grams of isophthalic acid, and 2.0 grams of FASCAT 9100 butyl hydroxy. Oxostannane catalyst (available from Total Petrochemicals USA, Inc., Houston, USA).

The contents of the flask were slowly heated to 225° C.-235° C. under a nitrogen blanket to distill off water from the resulting polycondensation reaction. Once the reaction mixture became clear and the temperature at the head of the column dropped, the reaction mixture was cooled to 160° C. and 85.5 grams of isophthalic acid and 16.0 grams of maleic anhydride were added to the flask. The reaction mixture was slowly reheated to 220-230° C. under a nitrogen blanket.

When the reaction mixture becomes clear and the head temperature of the packed column drops, cool the reaction mixture in the flask to 200° C. and replace the packed column with a Dean & Stark column for azeotropic distillation and 30.0 grams of xylene was added to the flask. The contents of the flask were reheated to reflux under a nitrogen blanket and more water was distilled off until the acid number of the reaction mixture dropped below 5. The contents of the flask are cooled to 145° C.-150° C., then 744.6 grams of butyl glycol, 104.7 grams of n-butanol, and 219.6 grams of xylene are added to form a solution of dissolved polyester. bottom.

A 5-liter flask was equipped with a stirrer, reflux condenser, thermocouple, heating mantle, and nitrogen blanket. A sample of the solution of dissolved polyester prepared above (1782.0 grams) and butyl glycol (123.0 grams) were placed in a 5 liter flask and preheated to 120° C. under a nitrogen blanket. In a separate flask, 321.0 grams of ethyl acrylate, 68.3 grams of glacial acrylic acid, 96.1 grams of styrene and 11.9 grams of VAZO 67 free radical initiator (2,2'-azobis(2- methyl-butyronitrile, available from Du Pont de Nemours, Wilmington, Del., USA) was then premixed with the monomer and initiator mixture at a temperature of 120° C.-122° C. for 135 minutes under a nitrogen blanket. The temperature in the 5 liter flask was then maintained at 122° C. for 1 hour.

Following this, 2.6 grams of TRIGONOX C free radical initiator (tert-butyl peroxybenzoate, available from Akzo Nobel) was added to the 5 liter flask and the reactor temperature was maintained at 122° C. for 2 hours. . The reaction mixture was then cooled to 105° C. and a premix containing 150.3 grams of dimethylethanolamine and 150.3 grams of deionized water was added over 10 minutes to a 5 liter flask, followed by Hold for 10 minutes. The reaction mixture dropped in temperature to 90° C. at the end of the addition. Finally, 2554 grams of water was added to the 5 liter flask over 30 minutes to convert the polyester acrylate solution into an aqueous dispersion of polyester acrylate.

A 60% solution of VARCUM 2227 phenolic resin (211 grams) (Reichhold Corporation, Durham, USA) was added to a post-conversion polyester acrylate resin that had a temperature of about 60°C after the final addition of water to the polyester acrylate resin was complete. entrapped in resin. There was a 20 minute hold after the addition of the VARCUM 2227 resin.

The aqueous dispersion of polyester acrylate phenolic is based on the total weight of the aqueous dispersion of polyester acrylate phenolic measured by heating a sample of 1 gram of the aqueous dispersion of polyester acrylate phenolic at a temperature of 150° C. for 60 minutes. , contained 29.8% by weight solids (non-volatiles). The aqueous dispersion of polyester acrylate phenolic had a pH of 8.53 standard pH units at a temperature of about 20°C.

To 70.43 parts of the polyester acrylic phenolic resin prepared above was added, under stirring, 14.40 parts deionized water, 0.022 parts CYCAT 600 aromatic sulfonic acid, 10.75 parts w-butanol, and a premix consisting of 2.57 parts CYMEL 303 hexamethoxymethymelamine. To the resulting composition under stirring was added 0.17 parts carnauba wax emulsion and 0.65 parts BACOTE 20 AZC (MEL Chemicals, Manchester, UK; diluted to 10% with water). The resulting product is suitable for spray application on beverage cans and interiors and crosslinks at elevated temperatures.

However, in the following examples, Valspar 40Q60AA (available from The Valspar Corporation, Minneapolis, USA) was used as the bisphenol A-free polyester acrylate-containing layer (lining A). To illustrate the effect of the present invention, a bisphenol A-free polyester acrylate-containing layer was added without the addition of resveratrol or directly into a solution suitable for spray application at 0.001% by weight, 0.01% by weight. % and 0.1% by weight.

Epoxy acrylate-containing layer (prepared according to Example 18 of WO 2008/036629 A2)
A 5-liter flask was equipped with a stirrer, reflux condenser, thermocouple, heating mantle, and nitrogen blanket. Low molecular weight liquid epoxy and bisphenol A were added to a reactor with butyltriphenylphosphonium bromide catalyst and xylene. A nitrogen purge was applied and heat was applied initially, after which an exotherm raised the temperature in the reactor.

A target weight per epoxy number of about 2900-3100 was achieved with a typical reaction time of 6 hours. Butyl glycol, n-butanol, and amyl alcohol solvents were then added slowly over 90 minutes. The acrylic monomer styrene and methacrylic acid plus benzoyl peroxide initiator LUCIDOL 78 (available from Akzo Nobel, Amsterdam, The Netherlands) were then added to the monomer addition tank. After stirring, the acid number of this monomer/catalyst premix was determined. The monomer/catalyst was then slowly added to the hot epoxy solution and acrylic polymerization occurred. The epoxy acrylic resin solution was then cooled and discharged from the reactor into a thinning tank containing a solution of water and diaminoethanolamine. The epoxy acrylic solution formed a dispersion in water upon conversion.

To 76.02 parts of the epoxy-acrylic resin dispersion prepared above was added, with stirring, 18.82 parts deionized water, 3.68 parts w-butanol, and 0.25 parts dimethylaminoethanol and 1.5 parts dimethylaminoethanol. A premix consisting of 23 parts deionized water was added. The resulting product was suitable for spray application to the interior of beverage cans and crosslinked at elevated temperatures.

However, in the examples below, Aqualure 900 (available from Akzo Nobel, Amsterdam, The Netherlands) was used as the epoxy acrylate containing layer (lining B). To exemplify the effect of the present invention, the epoxy acrylate-containing layer was coated with 0.001 wt%, 0.01 wt% and 0.1 wt% directly into a solution suitable for spray application without the addition of resveratrol. % by weight was added and prepared.

Example 2
Application of resveratrol-containing coating layer to packaging material/container walls (before/after container formation)
The lacquer described in Example 1 was applied as a coating layer to an aluminum can using a twin gun to cover the inner wall and dome of the can. The amount of lacquer to be applied depends on the size of the cans to be coated. In this example, cans having a volume of 150-440 ml were coated with 100-240 mg of lining A or lining B containing 0.01 wt% resveratrol.

The uncured coating layer is cured at a bake temperature of 180-250° C. for 80-230 seconds. The resulting layer distribution thickness lies between 3.5 and 8.4 g/m ² (gsm). Film layer thicknesses are shown in Table 1 for the top, middle, bottom and dome portions of cans coated with Lining A containing 0.01 wt% resveratrol.

Example 3
Evaluation of Physical Parameters of Coated Cans Cans coated in Example 2 were tested for adhesion of the coating layer (AS 1580 Method 408.4), impact resistance at 18 joules (AS 1580 Method 406.1), in HCl. was examined for pinholes (SSL test method) after incubation for 5 minutes at . The cans were also examined microscopically for blistering (AS 1580 Method 481.1.9), delamination (AS 1580 Method 481.1.10) and corrosion (AS 1580 Method 481.3). In all tests, the cans performed excellently and maintained the integrity of the coating layer. The results of these tests are shown in Table 2.

Example 4
Sensory Evaluation of Packaged Red Wine Red wine was packaged in 250 ml slim cans obtained in Example 2 and then stored for 24 months. Sensory evaluation was performed initially, after 3 months, after 6 months, after 12 months and after 24 months. Table 3 shows the results of this example.

Example 5
Sensory Evaluation of Packaged White Wine White wine was packaged in 250 ml slim cans obtained in Example 2 and then stored for 24 months. Sensory evaluation was performed initially, after 3 months, after 6 months, after 12 months and after 24 months. Table 4 shows the results of this example.

Example 6
Sensory Evaluation of Packaged Carbonated Red Wine Carbonated red wine was packaged in 250 ml slim cans obtained in Example 2 and then stored for 24 months. Sensory evaluation was performed initially, after 3 months, after 6 months, after 12 months and after 24 months. Table 5 shows the results of this example.

Example 7
Sensory Evaluation of Packaged Carbonated White Wine Carbonated white wine was packaged in 250 ml slim cans obtained in Example 2 and then stored for 24 months. Sensory evaluation was performed initially, after 3 months, after 6 months, after 12 months and after 24 months. Table 6 shows the results of this example.

Example 8
Comparative test of commercial lacquer-coated cans against cans of the invention The cans obtained in Example 2 are tested against commercial lacquer-lined cans. Standard cans with comparative lacquers were obtained from the market (comparative cans 1 and 2, respectively). All containers were filled with wine and stored for 24 months. Sensory evaluations were performed by a panel of 16 consumers initially, after 6 months, after 12 months, after 18 months and after 24 months. The results of this example are shown in Table 7 (red wine), Table 8 (white wine) and Table 9 (rosé wine).

Example 9
Comparative test of wine cans coated with a coating layer containing resveratrol according to the invention against comparative cans coated with a coating layer without resveratrol. Packed in 250 ml slim cans coated with lining A or lining B with no trol or 0.001 wt%, 0.01 wt% or 0.1 wt% resveratrol and then stored. The key attributes of the wine were assessed initially, after 6 months and after 24 months by a panel of 16 consumers, and resveratrol levels in the wine were evaluated using the "Method to determine resveratrol and pterostilbene in grape berries and wines using high-performance liquid chromatography and highly sensitive fluorometric detection", Pezet et al., Journal of Chromatography A, Volume 663, Issue 2, March 11, 1994, pages 191-197, initially and after 6 months. Table 10 shows the results.

Example 10
Quality Assessment of Packaged Vegetable and Beef Stews Fresh vegetables or beef stew are packaged in cans obtained in Example 2 (coating weight 6 g/m ² ; lining with 0.1 wt. % resveratrol). , then stored for 24 months. Sensory evaluation was performed initially, after 3 months, after 6 months, after 12 months and after 24 months. The average shelf life of canned products without noticeable deterioration in taste, odor and appearance could be extended by up to 18% with the containers of the invention.

Example 11
Quality Evaluation of Body Lotion As in Example 10, a commercially available body lotion (o/w type; oil-in-water emulsion) was packaged in the can obtained in Example 2 (coating weight: 10 g/m ² ; lining with 1% resveratrol by weight), then stored at elevated temperature of 36°C. The average shelf life without noticeable deterioration in odor and appearance of the canned product could be extended by up to 26% with the containers of the invention.

Claims (18)

A container for a consumable, wherein the inner surface of the container is coated with a coating layer containing resveratrol, the consumable is selected from solid, liquid or gas components, and the resveratrol comprises is selected from the group consisting of cis-resveratrol, trans-resveratrol and mixtures thereof, and a portion of the resveratrol present in the coating layer is shared with other components including polymers of the coating layer unbound container. 2. The container of claim 1, wherein the coating layer has a thickness of about 0.1 μm to 10 mm. 2. The container of claim 1, wherein the coating layer has a thickness of about 1 μm to 10 mm. 2. The container of claim 1, wherein the consumable is a beverage selected from wine, wine-based products, soft drinks, fruit juices, milk or whey-based products, lemonade, acidic beverages, and carbonated beverages. 3. The container of Claim 1, wherein the consumable comprises wine or a wine-based product. 2. The container of claim 1, wherein the concentration of resveratrol varies across the cross-section of the coating layer. 7. The container of Claim 6, wherein the concentration of resveratrol in the coating layer at or near the consumable is higher than the concentration at the inner surface of the container. 7. The container of Claim 6, wherein the concentration of resveratrol in the coating layer near the inner surface of the container is higher than the concentration at or near the consumable. 2. The container of Claim 1, wherein the coating layer comprises a lacquer or lacquer-based coating. 2. The container of Claim 1, wherein the coating layer does not contain bisphenol A or bisphenol A-based materials. 2. The container of Claim 1, wherein the coating layer further comprises free metal radicals. 2. The container of Claim 1, wherein the coating layer further comprises a water-based monomer enhancer. 2. The container of Claim 1, wherein the coating layer further comprises a polyester acrylate. A method for preparing a container for consumables, said method comprising:
a) providing a container comprising a container wall comprising an inner surface facing the interior space of the container; and b) providing a coating layer comprising resveratrol on the inner surface of said container wall.
wherein said consumable is a beverage selected from wine, wine-based products, soft drinks, fruit juices, milk or whey-based products, lemonade, acidic beverages, and carbonated beverages; is selected from the group consisting of cis-resveratrol, trans-resveratrol, and mixtures thereof, and a portion of the resveratrol present in the coating layer comprises a polymer of the coating layer; A method that is not covalently attached to a component. A container according to any one of claims 1 to 13, wherein the container consists of glass, metal, polymeric material, paper, cardboard, or combinations thereof. 16. Container according to claim 15, wherein the container consists of aluminum and/or polymeric material. 15. The method of claim 14, wherein the container is made of glass, metal, polymeric material, paper, cardboard, or combinations thereof. 18. A method according to claim 17, wherein the container consists of aluminum and/or polymer material.