JP7256624B2 - Gel-form external preparation for skin or skin cosmetics - Google Patents

Description

TECHNICAL FIELD The present invention relates to a gel-like external preparation for skin or a skin cosmetic. More specifically, it relates to a gel-type external preparation for skin or a skin cosmetic containing nicotinic acid amide, which improves firmness and elasticity of the skin, is excellent in thickness during application, has no sticky feeling, and has excellent stability over time.

The skin develops spots, wrinkles, sagging, pigmentation, etc. due to internal factors such as aging and stress, and external factors such as ultraviolet rays and dry air. Above all, morphological changes such as wrinkles and sagging greatly affect the impression of appearance, and many people desire improvement. Many drugs have been proposed to prevent and improve such wrinkles and sagging. Among these, nicotinic acid amide is a vitamin and is known to be highly safe and to have an anti-aging effect on the skin (Patent Documents 1 and 2). However, it is known that when a large amount of nicotinic acid amide is contained, there is an undesirable feel during use, such as strong stickiness, and improvements have been made (Patent Document 3).

JP-A-10-130135 JP-A-10-1414 Japanese Patent Publication No. 2003-502435

Patent Document 3, which attempts to suppress the sticky feeling of nicotinic acid amide, is a technique of containing both a branched hydrocarbon and a highly spreadable oil such as a liquid ester emollient, but the effect was insufficient. In addition, there is a problem that creaming may occur over time.

Therefore, the present inventors combined a silicone oil capable of improving stickiness and a polyether-modified silicone in water containing nicotinic acid amide at a high concentration (1 to 10% by mass). An attempt was made to improve the sticky feeling peculiar to nicotinic acid amide. However, depending on the type of polyether-modified silicone and the mass ratio of silicone oil to polyether-modified silicone content, poor stability over time may occur, or the thickness during application may be insufficient, causing dripping. There still existed cases such as poor usability. In view of this situation, the present inventors have made intensive studies to solve the above problems, and as a result, 1 to 10% by weight of nicotinic acid amide, a silicone oil having a viscosity of 25 mPa s or less at 25 ° C., and water In the composition, one or more selected from specific polyether-modified silicones (PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG-10 dimethicone, PEG-12 dimethicone ), and the content mass ratio of the silicone oil of 25 mPa s or less and the specific polyether-modified silicone (silicone oil of 25 mPa s or less) / (specific polyether-modified silicone) is 1 to 5 In some cases, it was found that the sticky feeling peculiar to nicotinic acid amide was improved, and the stability over time was remarkably good. Furthermore, as a result of intensive studies as a thickener, among polysaccharides, when carboxymethyl cellulose is also included, the stability over time and the thickness during application are significantly improved, and surprisingly, the skin is thickened. The present inventors have found that it is possible to provide a gel-like skin preparation for external use or a skin cosmetic with improved firmness and elasticity and reduced stickiness.

Thus, the present invention provides the following components (A) to (E):
(A) Nicotinamide 1 to 10% by mass
(B) a silicone oil having a viscosity of 25 mPa s or less at 25°C; containing one or more (D) carboxymethyl cellulose (E) water, and
Provided is a gel-like skin external preparation or skin cosmetic in which the content mass ratio (B)/(C) of component (B) and component (C) is 1 to 5.

Furthermore, the present invention provides
Provided is a gel-like skin preparation for external use or a skin cosmetic in which the content ratio (A)/(D) of the component (A) and the component (D) is 20-180.

Furthermore, the present invention provides
Provided is a gel-like skin preparation for external use or skin cosmetic in which the content mass ratio (A)/(C) of the component (A) and the component (C) is 1 to 12.

Furthermore, the present invention provides
To provide a gel-like skin external preparation or skin cosmetic, which is a pretreatment skin external preparation or skin cosmetic.

The gel-type external preparation for skin or skin cosmetic of the present invention not only improves the firmness and elasticity of the skin, is excellent in thickness during application, and provides an excellent feeling of use without stickiness, but also has good stability over time. It is excellent. Furthermore, pretreatment skin preparations for external use or skin cosmetics are preferred as applications of the gel-like external preparation for skin or skin cosmetics of the present invention. After applying the gel-like external skin preparation or skin cosmetic of the present invention as the first agent, when another skin external preparation or skin cosmetic is used, unexpectedly, the second agent, the external skin preparation or skin cosmetic, The feeling of permeation during use of the cosmetics was improved compared to when the cosmetics were used alone, and the lack of sticky feeling after use was improved compared to when the second agent was used alone.

The present invention will be described in detail below. In this specification, "-" shall mean a range including numerical values before and after it.

Component (A): Nicotinamide Component (A) nicotinamide in the present invention is an amide compound of nicotinic acid (vitamin B3/niacin). Nicotinamide is a water-soluble vitamin, a known substance that is one of the vitamin B group, and can be extracted from natural products (such as rice bran) or synthesized by a known method. Specifically, those listed in the Japanese Pharmacopoeia 2008, 15th Edition can be used.

In the present invention, the content of component (A) is 1 to 10% by mass (hereinafter simply “mass%” is abbreviated as “%”) in order to improve the firmness and elasticity of the skin and suppress stickiness. Yes, preferably 2 to 7%, more preferably 3 to 6%. If the content of component (A) is less than 1%, the effect of imparting firmness and elasticity to the skin is not excellent. .

Component (B): Silicone oil having a viscosity of 25 mPa·s or less at 25°C The silicone oil of Component (B) in the present invention has a viscosity of 25 mPa·s or less at 25°C.

In the present invention, the viscosity of the component (B) is measured according to the Second Method of Viscosity Measurement Method, Standards for Cosmetic Ingredients, using a Brookfield viscometer. Component (B) is not particularly limited, but examples thereof include dimethicone, decamethyltetrasiloxane, octamethyltrisiloxane, trisiloxane, and methyltrimethicone, which have a viscosity of 25 mPa·s or less at 25°C. Among these, dimethicone, decamethyltetrasiloxane, and octamethyltrisiloxane, which have a viscosity of 25 mPa·s or less at 25° C., are preferable from the viewpoint of reducing the stickiness of the gel-like external skin preparation or skin cosmetic. , and dimethicone are more preferable, and the component (B) can be used alone or in combination of two or more.

The content of component (B) is not particularly limited, but is preferably 0.1 to 8%, more preferably 0.2 to 6%, from the viewpoint of improving the thickness during application of the gel-type external skin preparation or skin cosmetic. More preferably, 0.5-5% is more preferred, and 1-4% is even more preferred.

The viscosity of component (B) is not particularly limited as long as it is 25 mPa·s or less at 25° C. and exceeds 0 mPa·s. From the viewpoint of improving the thickness and stickiness during application of the gel-like external skin preparation or skin cosmetic and improving the stability over time, the viscosity at 25°C is preferably 0.5 to 20 mPa s, more preferably 1 to 20 mPa s. 1.5 to 15 mPa·s is even more preferable.

Component (C): One or more selected from PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG-10 dimethicone, and PEG-12 dimethicone

Component (C) in the present invention is a polyether-modified silicone, and includes PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG- 10 dimethicone, PEG-12 dimethicone. These can be used alone or in combination of two or more. , PEG-11 methyl ether dimethicone, PEG-9 dimethicone, preferably one or two or more selected from PEG-10 dimethicone, PEG-11 methyl ether dimethicone, one or two selected from PEG-9 dimethicone The above is more preferable, and the combined use of PEG-11 methyl ether dimethicone and PEG-9 dimethicone is even more preferable. When component (C) is not contained and only polyether-modified silicone other than PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG-10 dimethicone, and PEG-12 dimethicone is contained In some cases, the stability over time cannot be maintained well, the feeling of squeaky feeling is strong, and the usability is not excellent.

The content of component (C) is not particularly limited, but is preferably 0.01 to 5%, more preferably 0.1 to 4%, from the viewpoint of improving the stickiness of the gel-like external skin preparation or skin cosmetic and improving the stability over time. is more preferred, and 1 to 4% is even more preferred.

Component (C) is not particularly limited as long as it is used in ordinary skin cosmetics, but specific examples include "SH3771M (PEG-12 dimethicone)", "SS-2801 (PEG-10 methyl ether dimethicone)”, “SS-2802 (PEG-10 methyl ether dimethicone)”, “SS-2804 (PEG-12 dimethicone)” (manufactured by Dow Corning Toray), “KF-6013” (PEG-9 dimethicone ) and “KF-6017 (PEG-9 dimethicone)” (manufactured by Shin-Etsu Chemical Co., Ltd.), which can be used in the present invention.

Component (D): Carboxymethylcellulose Component (D) in the present invention is carboxymethylcellulose, which is one of cellulosic polymers. Moreover, as carboxymethylcellulose, when containing a salt, the salt is not specifically limited. Examples of carboxymethylcellulose salts include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as ammonium, triethanolamine and triethylamine, and basic amino acid salts such as lysine and arginine. It can be exemplified preferably.

The content of component (D) is not particularly limited, but is preferably 0.01 to 1%, and preferably 0.02%, from the viewpoint of improving thickness during application of a gel-type external skin preparation or skin cosmetic and improving stability over time. ~0.1% is more preferred, and 0.03-0.08% is even more preferred.

Component (D) can be used without particular limitation as long as it is used in ordinary skin cosmetics. Daicel 1270", "CMC Daicel 1280", "CMC Daicel 1290", "CMC Daicel 1350", and "CMC Daicel 1380" (manufactured by Daicel Chemical Industries, Ltd.).

Component (E): Water The component (E) water used in the present invention is not particularly limited as long as it is commonly used in cosmetics. In addition to water, purified water, hot spring water, deep-sea water, or steam-distilled water from plants may be used, and one or more of them may be appropriately selected and used as necessary. Moreover, the content is not particularly limited, and can be appropriately contained depending on the amount of other components, and is preferably 20 to 90%.

The component (B) used in the present invention is a component that is blended with the expectation of improving the sticky feeling peculiar to the component (A). be. Surprisingly, when the content ratio (B)/(C) was 1 to 5, the stability over time was improved, and further, the sticky feeling peculiar to component (A) was improved. Further, the content ratio (B)/(C) is preferably 2 to 4 from the viewpoint of improving stability over time and improving stickiness. On the other hand, when the content ratio (B)/(C) is less than 1, when the gel-type external preparation for skin or skin cosmetic is applied to the skin, the thickness during application may not be excellent, and the feeling of stickiness may be strong. . If the content ratio (B)/(C) exceeds 5, the thickness during application may not be excellent, the stability over time may be poor, and the stickiness may be strong.

Component (A) in the present invention is a polar molecule, but depending on the type and amount of the polar molecule, it may interact with component (D) to significantly reduce the viscosity and reduce the thickness during application. The content ratio (A)/(D) of the component (A) and the component (D) is not particularly limited, but is preferably 20 to 180, and 30 to 160, from the viewpoint that the thickness during application is remarkably good. More preferably, 40 to 140 is particularly more preferable.

Furthermore, the component (A) in the present invention has a peculiar sticky feeling, and the sticky feeling is strong, and the component (C) is also a component having a strong sticky feeling depending on the case. Although the content ratio (A)/(C) of the component (A) and the component (C) is not particularly limited, the content ratio (A)/(C) is 1 to 1 in terms of improving stickiness. 12 is preferred, 2 to 9 are preferred, and 2.5 to 8.75 are more preferred.

The form of the gel-like external preparation for skin or skin cosmetic of the present invention is not particularly limited, such as an emulsified type, a solubilized type, or a dissolved type. It is important that the components (A) to (E) are contained and the content mass ratio (B)/(C) is 1 to 5. In order to improve the thickness during application and further improve the stickiness, an emulsified gel-type external skin preparation or skin cosmetic is preferable in terms of increasing the content of component (B), and among these, oil-in-water. A type of gel-like external skin preparation or skin cosmetic is more preferable.

In addition to the components (A) to (E), the gel-like external preparation for skin or skin cosmetic of the present invention contains optional components contained in ordinary cosmetics within a range that does not impair the effects of the present invention, that is, components Other than (A) to (E), lower alcohols, water-based components, oil-based components, powders, water-soluble polymers, film-forming agents, surfactants, oil-soluble gelling agents, organically modified clay minerals, resins, coloring agents , ultraviolet absorbers, preservatives, antibacterial agents, fragrances, antioxidants, pH adjusters, chelating agents, cosmetic ingredients, and the like.

The "gel-like" of the gel-like external preparation for skin or skin cosmetic of the present invention means a state in which viscosity is imparted. Viscosity at 20°C measured according to the second method is in the range of 1,000 to 100,000 mPa·s. From the viewpoint of thickness during application and stability over time, it is preferably 3,000 mPa s or more, more preferably 5,000 mPa s or more, and preferably 80,000 mPa s or less, and 50,000 mPa s. The following are more preferred. A specific range is preferably 3,000 to 80,000 mPa·s, more preferably 5,000 to 50,000 mPa·s. Within these viscosity ranges, the thickness during application is excellent, there is no dripping, and the stability over time is also excellent. If the viscosity at 20°C is less than 1,000 mPa·s, the thickness during application may be poor and the stability over time may not be excellent. If the viscosity at 20°C exceeds 100,000 mPa·s, the thickness during application may be poor and the stickiness may be strong.

The method for producing the gel-like external preparation for skin or skin cosmetic of the present invention can be produced by a known method, regardless of emulsification or solubilization, without particular limitation. In order to improve stickiness, it is preferable to use an emulsification method in terms of increasing the content of component (B). law, etc. In terms of obtaining a gel-like topical skin preparation or skin cosmetic excellent in emulsification stability over time, a preferred manufacturing method is to heat and mix components (B), (C) and other oily components. Later, the heated component (E) is added and mixed to emulsify, and then components (A) and (D), and optionally other aqueous components are added and mixed. .

The gel-like external skin preparation or skin cosmetic of the present invention can be used as a skin external preparation. Examples include external liquids, external gels, creams, ointments, liniments, lotions, poultices, plasters, sprays, aerosols, and the like. Examples of the method of use include a method of using hands, fingers, cotton, and a method of impregnating a non-woven fabric or the like.

The gel-like external preparation for skin or skin cosmetic of the present invention can be used as a skin cosmetic. For example, lotions, milky lotions, creams, beauty essences, massage agents, face packs, hand creams, body lotions, body creams, sunscreen agents, foundations, eyeshadows, eyeliners, concealers and the like can be mentioned. Examples of the method of use include a method of using hands, fingers, cotton, and a method of impregnating a non-woven fabric or the like.

Among the above uses, the product of the present invention is preferably used as a massaging agent because it is excellent in thickness and non-stickiness during application. By using it as a massage agent, other effects such as promoting blood circulation can be expected, and further improvements in the firmness and elasticity of the skin can be expected.

The gel-like external skin preparation or skin cosmetic of the present invention is preferably used as a pretreatment skin external preparation or skin cosmetic. In the present invention, the pretreatment skin external preparation or skin cosmetic is defined as the first agent that is used first and the second agent that is used later when two external skin preparations or skin cosmetics are applied. Defined as the first agent when There are no particular restrictions on the external skin preparation or skin cosmetic of the second agent, and various external skin preparations and skin cosmetics can be used. For example, external skin preparations include external liquids, gels, creams, ointments, liniments, lotions, poultices, plasters, sprays, aerosols, and the like. Examples include water, milky lotion, cream, beauty essence, massage agent, pack agent, hand cream, body lotion, body cream, sunscreen agent, foundation, eye shadow, eyeliner, concealer, and the like. Among them, from the viewpoint of improving the sticky feeling after applying the second agent to the skin, the content of the oily component in the second agent is preferably 5% or less. External preparations include external liquids, external gels, lotions and the like, and skin cosmetics include lotions, beauty essences, milky lotions, body lotions and the like. When used as a pretreatment skin preparation for external use or a skin cosmetic, use of massage is not particularly limited, but from the viewpoint of improving penetration feeling when applying the second agent, it is preferably used as a massage agent.

When the gel-like external skin preparation or skin cosmetic of the present invention is used as a pretreatment skin external preparation or skin cosmetic, in terms of improving the feeling of penetration when applying the second agent, the second agent has an amphipathic Substances are preferably included. The amphiphilic substance in the present invention refers to a substance having a hydrophilic group and a hydrophobic group in terms of molecular structure, and is not particularly limited. As the amphiphilic substance contained in the second agent, a substance having a polyoxyethylene chain as a hydrophilic group is preferable, particularly from the viewpoint of improving stickiness after application of the second agent. Polysorbate 80 is more preferable from the viewpoint of improving stickiness.
In addition, from the viewpoint of improving the feeling of penetration when the second agent is applied, the mass ratio (A)/( C) is preferably between 2.5 and 20/3.

EXAMPLES The present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these. Unless otherwise specified, the content is shown in % by mass relative to the system containing the component.

Examples 1 to 9, Comparative Examples 1 to 12: Essence The essences of Examples 1 to 9 and Comparative Examples 1 to 12 were prepared. : Absence of sticky feeling, d: Stability over time was evaluated by the following method. Tables 1 to 3 show the formulations and evaluation results of these beauty essences.

(Production method)
A: Components (1) and (10) to (12) are uniformly dissolved and mixed at 70°C.
B: Components (2) to (9) are uniformly dissolved and mixed at 70°C.
C: Components (13) and (14) are uniformly dissolved and mixed.
D: Emulsification was performed by adding B to A and mixing, and after cooling to 40° C., C was added and mixed to obtain a beauty essence.

(Evaluation item)
A: Feeling of firmness and elasticity of the skin B: Thickness during application C: Absence of stickiness D: Stability over time

(Evaluation method)
[About A, B, and H (sensory evaluation)]
A panel of 10 women in their 20s to 40s who had undergone sensory evaluation training and were able to evaluate according to a certain standard was selected. Each sample was evaluated by a panel of specialists on the firmness, elasticity, and lack of stickiness of the skin when applied to the skin. , the average value was calculated and judged according to the following 4-step judgment criteria.

(B: skin firmness and elasticity)
Absolute Evaluation Criteria (Rating): (Rating)
6 points: The skin feels very firm and elastic 5 points: The skin feels firm and elastic 4 points: The skin feels somewhat firm and elastic 3 points: Normal 2 Score: I do not feel that my skin has a lot of firmness and elasticity. 1 point: I do not feel that my skin has a firmness and elasticity.
◎: More than 4.5 points: Very good ○: More than 3 points and 4.5 points or less: Good △: More than 1.5 points and 3 points or less: Somewhat poor ×: 1.5 points or less: Poor

(B: Thickness during application)
Absolute Evaluation Criteria (Rating): (Rating)
5 points: No dripping, feeling very good thickness 4 points: No dripping, feeling good thickness 3 points: No dripping, feeling thickness 2 points: No dripping However, the thickness is hardly felt 1 point: There is no thickness and it drips down.
◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Somewhat poor ×: 2 points or less: Poor

(C: No stickiness)
Absolute Evaluation Criteria (Rating): (Rating)
5 points: no sticky feeling 4 points: almost no sticky feeling 3 points: slightly sticky feeling 2 points: sticky feeling 1 point: very sticky feeling average score)
◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Somewhat poor ×: 2 points or less: Poor

(D: Stability over time)
Each sample was stored in a constant temperature bath at 50° C. for 1 month, and the condition within 1 month was visually confirmed and evaluated according to the following criteria.
Four-stage judgment criteria (judgment): (state of appearance)
◎: No change within 1 month: Very good ○: No creaming observed within 3 weeks,
Creaming observed within 1 month: Good △: No creaming observed within 2 weeks,
Creaming observed within 3 weeks: Slightly poor ×: Creaming observed within 2 weeks: Poor

As is clear from the results in Tables 1 to 3, the beauty essences of Examples 1 to 9 have less skin firmness/elasticity, thickness during application, and less stickiness than the beauty essences of Comparative Examples 1 to 12. It was excellent in stability over time.
On the other hand, Comparative Example 1 containing no component (B) was inferior in thickness and lack of stickiness during application.
Comparative Example 2, which does not contain component (C), could not be emulsified, the system was separated, and it was not ready for use.
Comparative Example 3, which does not contain component (D), was inferior in thickness during application, absence of sticky feeling, and stability over time.
Comparative Example 4, in which the content ratio (B)/(C) exceeded 5, was inferior in firmness, elasticity, and stability over time.
Comparative Example 5, in which the content ratio by mass (B)/(C) was less than 1, was inferior in thickness during application and lack of stickiness.
Comparative Example 6, which did not contain component (B) and contained only silicone oil having a viscosity of more than 25 mPa·s at 25° C., was inferior in firmness, elasticity, and stability over time.
Comparative Example 7 containing sorbitan sesquioleate without component (C), Comparative Example 8 containing polyglyceryl-3 polydimethylsiloxyethyl dimethicone, and Comparative Example 9 containing PEG-9 polydimethylsiloxyethyl dimethicone , the thickness during application, the lack of stickiness, and the stability over time were inferior.
Comparative Example 10 containing hydroxypropylmethylcellulose without component (D) was inferior in thickness during application and lack of stickiness.
Comparative Example 11, in which the content of component (A) was less than 1%, was inferior in firmness/elasticity and stability over time.
Comparative Example 12, in which the content of component (A) exceeded 10%, was inferior in terms of firmness and elasticity of the skin and lack of stickiness.

Use Examples 1 to 11: Use of first agent (pretreatment serum) and second agent An example of using it as a beauty essence) and then using an external skin preparation or skin cosmetic as the second agent is shown. made an evaluation. Formulation Examples A to C (skin lotion) of the second agent are shown in Table 4, and Formulation Examples D and E (emulsion) are shown in Table 5. Examples 1, 4, 5, 7, 8 and Comparative Example 11 were used as the first agent, and Formulation Examples A to E and Example 1 were used as the second agent, respectively. Table 6 shows the combination and the evaluation results evaluated by the following method.

(Manufacturing method of formulation examples A to C of second agent (skin lotion))
A: Components (1) to (4) and (9) are uniformly dissolved and mixed at 25°C.
B: Components (5) to (8) and (10) are uniformly dissolved and mixed at 25°C.
C: A lotion was obtained by adding A to B and mixing.

(Manufacturing method of formulation examples D and E of second agent (emulsion))
A: Components (3) to (8) are uniformly dissolved and mixed at 70°C.
B: Components (9) to (14) and (16) are uniformly dissolved and mixed at 70°C.
C: Emulsification was performed by adding A to B and mixing, and after cooling to 40° C., components (1), (2) and (15) were added and mixed to obtain an emulsion.

(Evaluation item)
E: Penetration feeling when applying the second agent F: No sticky feeling after applying the second agent

(Evaluation method)
[E and F (sensory evaluation)]
A panel of 10 women in their 20s to 40s who had undergone sensory evaluation training and were able to evaluate according to a certain standard was selected. After each specialized panel applied the first agent (1.0 g) to the skin and let it blend with the skin for 30 seconds, the feeling of penetration felt when the second agent (1.0 g) was applied, and the application of the second agent Absence of sticky feeling afterward was evaluated in 5 stages according to the following absolute evaluation, and a score was assigned. For each use example, the average value was calculated from the total score of all the panelists, and judged according to the following 4-step criteria.

(E: sense of penetration when applying the second agent)
Absolute Evaluation Criteria (Rating): (Rating)
5 points: Compared to using the second agent alone, when the second agent is applied after the first agent, a very high sense of penetration is felt 4 points: Compared to using the second agent alone, the first agent When the second agent is applied after the application of the agent, a high penetration feeling is felt. Feel 2 points: Compared to when using the second agent alone, when the second agent is applied after applying the first agent, the same feeling of penetration is felt 1 point: Compared to using the second agent alone, the second agent When the second agent is applied after the first agent is applied, the sense of penetration is felt to be low 4-step judgment criteria (judgment): (average score)
◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Somewhat poor ×: 2 points or less: Poor

(F: Absence of stickiness after application of the second agent)
Absolute Evaluation Criteria (Rating): (Rating)
5 points: Compared to using the second agent alone, after applying the second agent after applying the first agent, the feeling of stickiness is very weak 4 points: Compared to using the second agent alone, the first agent After applying the second agent after applying the second agent, the feeling of stickiness is weak. 3 points: Compared to using the second agent alone, after applying the first agent, after applying the second agent, the sticky feeling is slightly weaker. Feel 2 points: Compared to after using the second agent alone, feel the same sticky feeling after applying the second agent after applying the first agent 1 point: Compared to after using the second agent alone, After applying the first agent and then applying the second agent, a sticky feeling is felt strongly.
◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Somewhat poor ×: 2 points or less: Poor

As is clear from the results in Table 6, Use Examples 1 to 10 were superior to Use Example 11 in terms of penetration feeling upon application of the second agent and lack of sticky feeling after application of the second agent.
In addition, among Use Examples 1, 6, and 7, Use Examples 1 and 7 are superior in terms of penetration feeling when applying the second agent and lack of sticky feeling after applying the second agent. Preferably, the agent contains an amphiphilic substance.
In addition, among Usage Examples 1 to 5, Usage Examples 1, 3, and 4 are superior in the sense of penetration when the second agent is applied, so the mass ratio (A)/(C ) is particularly preferably 2.5 to 20/3.
Among Usage Examples 1 and 7, Usage Example 1 is superior in terms of penetration feeling when applying the second agent and no sticky feeling after applying the second agent, and among Usage Examples 8 and 9. In , Usage Example 8 is superior in terms of penetration feeling when applying the second agent and lack of sticky feeling after applying the second agent, so the second agent is an amphiphilic substance containing a polyoxyethylene group. It is preferable to contain. Furthermore, in Use Examples 1 and 8, it is more preferable that the second agent contains polysorbate 80, since Use Example 1 is superior in terms of no sticky feeling after application of the second agent.
In addition, in Usage Example 10, in which Example 1 was applied as the first agent and Example 1 was again applied as the second agent, the feeling of penetration when the second agent was applied and the sticky feeling after the application of the second agent were better than in Usage Example 11. Excellent in nothingness.

Example 10: Oil-in-water emulsified cream (component) (%)
1.1,3-butylene glycol 12.0
2. Glycerin 5.0
3. Remaining purified water 4. Nicotinamide 6.0
5. Sodium ascorbate 0.5
6. Sodium metasilicate 0.05
7. Hydrogenated lecithin 0.5
8. Hydrogenated lysolecithin 0.5
9. PEG-11 methyl ether dimethicone (Note 4) 0.5
10. PEG-10 Dimethicone (Note 5) 0.3
11. Dimethicone (20 mPa s/25°C) (Note 1) 3.0
12. Ceramide 2 0.1
13. Astaxanthin 0.1
14. Tocopherol 0.01
15. Cetostearyl alcohol 2.0
16. behenyl alcohol 1.0
17. Glycerin monostearate 1.0
18. Methyl paraoxybenzoate 0.05
19. Carbomer 0.15
20. Carboxymethylcellulose 0.1
21. Sodium hydroxide 0.004
22. Perfume 0.05

(Production method)
A: Components (1) to (6) are uniformly dissolved and mixed at 70°C.
B: Components (7) to (17) are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After cooling C to 40°C, components (18) to (22) were added to obtain an oil-in-water emulsified cream.

The oil-in-water cream of Example 10 was excellent in all aspects of skin firmness/elasticity, thickness during application, absence of sticky feeling, and stability over time.

Example 11: Oil-in-water substrate
(Component) (%)
1.1,3-butylene glycol 7.0
2. Dipropylene glycol 5.0
3. Triethanolamine 0.4
4. Remaining purified water 5. Nicotinamide 4.0
6. Squalane 0.4
7. Stearic acid 1.0
8. PEG-80 hydrogenated castor oil 0.2
9. Sorbitan sesquiisostearate 0.1
10. PEG-9 Dimethicone 0.5
11. Dimethicone (6 mPa s/25°C) (Note 10) 2.0
12. Cetostearyl alcohol 0.3
13. behenyl alcohol 0.5
14. Methyl paraoxybenzoate 0.02
15. Talc 0.4
16. Hydrous silica 0.1
17. Mica 1.3
18. Titanium oxide 6.0
19. Iron oxide 0.1
20. Acrylic acid-alkyl methacrylate copolymer (Note 11) 0.3
21. Carboxymethylcellulose 0.1
22. sodium hydroxide 0.008
23. Glycine 0.01
24. Arginine 0.01
25. Perfume 0.01
Note 10: KF-96A-6cs (manufactured by Shin-Etsu Chemical Co., Ltd.)
Note 11: CARBOPOL 1382 (manufactured by LUBRIZOL ADVANCED MATERIALS)

(Production method)
A: Components (1) to (5) are uniformly dissolved and mixed at 70°C.
B: Components (6) to (14) are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After cooling C to 40°C, components (15) to (25) were added to obtain an oil-in-water base.

The oil-in-water type base of Example 11 was excellent in all of skin firmness/elasticity, thickness during application, absence of sticky feeling, and stability over time.

Example 12: Oil-in-water beauty essence
(Component) (%)
1.1,3-butylene glycol 5.0
2. Glycerin 5.0
3. Remaining purified water 4. Nicotinamide 6.0
5. Isostearic acid 0.1
6. Polysorbate 80 0.1
7. PEG-12 dimethicone (Note 12) 0.2
8. PEG-10 methyl ether dimethicone 0.16
9. Squalane 1.0
10. Methyl trimethicone (Note 13) 1.5
11. Linoleic acid 0.05
12. Ceramide 3 0.1
13. Tocopherol 0.01
14. Cetostearyl alcohol 0.5
15. Oleyl alcohol 1.0
16. Methyl paraoxybenzoate 0.01
17. Carbomer 0.15
18. (Na acrylate/Na acryloyldimethyltaurate) copolymer solution (Note 14)
0.1
19. Carboxymethylcellulose 0.07
20. sodium hydroxide 0.05
21. Ethanol 5.0
22. Sodium hyaluronate 0.01
23. Hydrolyzed hyaluronic acid 0.01
24. Hydrolyzed collagen 0.01
25. Glycosyl trehalose 0.1
26. Perfume 0.1
Note 12: SS-2804 (manufactured by Dow Corning Toray)
Note 13: TMF-1.5 (manufactured by Shin-Etsu Chemical Co., Ltd.)
Note 14: SIMULGEL EG (manufactured by SEPIC)

(Production method)
A: Components (1) to (4) are uniformly dissolved and mixed at 70°C.
B: Components (5) to (13) are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After cooling C to 40°C, components (14) to (26) were added to obtain an oil-in-water beauty essence.

The oil-in-water type beauty essence of Example 12 was excellent in all of skin firmness/elasticity, thickness during application, absence of sticky feeling, and stability over time.

Second Agent Formulation Example F: Emulsion (ingredient) (%)
1.1,3-butylene glycol 5.0
2. Glycerin 5.0
3. Remaining purified water 4. Citric acid 0.1
5. Hydrogenated lecithin 0.1
6. PEG-40 stearate 0.2
7. PEG-55 stearate 0.15
8. Squalane 5.0
9. Vaseline 0.5
10. Ceramide 3 0.1
11. Tocopherol 0.01
12. Cetostearyl alcohol 0.5
13. Oleyl alcohol 1.0
14. Hexa(hydroxystearic acid/stearic acid/rosin acid) dipentaerythrityl 3.0
15. Carbomer 0.15
16. (Na acrylate/Na acryloyldimethyltaurate) copolymer solution (Note 14)
0.1
17. sodium hydroxide 0.05
18. Ethanol 5.0
19. Sodium hyaluronate 0.01
20. Hydrolyzed hyaluronic acid 0.01
21. Hydrolyzed collagen 0.01
22. Glycosyl trehalose 0.1
23. PEG-8 0.1

(Production method)
A: Components (1) to (4) are uniformly dissolved and mixed at 70°C.
B: Components (5) to (14) are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After adding and mixing components (15) to (23) to C, the mixture was cooled to 40°C to obtain a milky lotion.

(how to use)
Example 12 (2.0 g) was applied to the skin as the first agent, and after allowing it to blend into the skin for 30 seconds, Formulation Example F: emulsion (3.0 g) was applied to the skin as the second agent.

The oil-in-water type beauty essence of Example 12 was a pretreatment oil-in-water type beauty essence that was excellent in permeation upon application of the second agent and absence of sticky feeling after application of the second agent.

Claims (4)

The following components (A)-(E):
(A) Nicotinamide 1 to 10% by mass
(B) a silicone oil having a viscosity of 25 mPa s or less at 25°C; 1 or 2 or more (D) sodium salt of carboxymethylcellulose 0.01 to 1% by mass
(E) contains water, and
An oil-in-water gel-like external skin preparation or skin cosmetic in which the content ratio (B)/(C) of the component (B) and the component (C) is 1 to 5. 2. The oil-in-water type gel-like external preparation for skin or skin cosmetic according to claim 1, wherein the content ratio (A)/(D) of component (A) and component (D) is 20-180. 3. The oil-in-water gel-like external preparation for skin or skin cosmetic according to claim 1 or 2, wherein the content ratio (A)/(C) of component (A) and component (C) is 1 to 12. 4. The oil-in-water type gel-like external preparation for skin or skin cosmetic according to any one of claims 1 to 3, which is a pretreatment skin preparation for external use or skin cosmetic.