JP7212597B2 - Chemical substance and chemical reaction risk assessment support system and its method - Google Patents

Description

The present invention relates to a research and development support system for improving the efficiency of research and development, and more particularly to a support system for risk assessment of research and development dealing with chemical substances and chemical reactions.

In recent years, companies are actively introducing IT for the purpose of improving productivity. In the manufacturing industry, a dedicated IT system has been introduced for the management of chemical substances handled in corporate activities. Specifically, companies need to understand the types and amounts of chemical substances related to products, make various notifications and applications, and monitor the human body and environment related to the chemical substances they handle throughout the entire product life cycle, including research and development, manufacturing, and disposal. Operations such as surface risk assessment are centrally managed using a chemical substance management system.

The chemical substance management system described above stores information on the physical and chemical properties of chemical substances, handling methods based on them, and risks to health and the environment for existing chemical substances in a dedicated database. or easily obtainable through the Internet. Patent document 1 is mentioned as an example regarding a chemical substance management system.

The chemical substance management system described above is linked to databases of various domestic and foreign laws and regulations that regulate chemical substances. One such law is the Chemical Substance Emission Control Promotion Law in Japan. This law aims to promote the improvement of voluntary management of chemical substances by businesses that handle chemical substances, and to prevent chemical substances from hindering environmental conservation. It stipulates the obligatory notification of such substances (PRTR system) and the obligatory provision of safety data sheets (SDS) for chemical substances (SDS system).

In addition, the chemical substance management system described above links multiple databases that store information such as the purchase of materials within a company, the management status at multiple business sites, and the sales status of the relevant chemical substances or products containing them. often do. For this reason, the chemical substance management system can collect necessary information for each phase of the product life cycle, and furthermore, can conduct risk assessments regarding the danger of chemical substances and their toxicity to humans and the environment.

Japanese Patent Application Laid-Open No. 2004-326707

In the research and development department of a company, when conducting work using chemical substances or experiments involving chemical reactions, there are cases in which risk assessments are conducted in advance regarding the safety of the entire experiment or work, including the chemical substances to be used and chemical reactions. many. Conventional chemical substance management systems perform risk assessment based on pre-registered information on the physical and chemical hazards of chemical substances and their hazards to humans and the environment.

In conventional chemical substance management systems, there is a lack of information that serves as a basis for judgments regarding chemical substances with novel structures, chemical substances with unknown structures or compositions, and chemical reactions themselves that may be handled in research and development departments. Because of this, it cannot adequately support risk assessment for chemicals and chemical reactions. In other words, when conducting risk assessments, corporate research and development departments lack information on chemical reactions and chemical substances with new structures. I can't carry it out.

Research and development departments of companies accumulate a variety of information about chemical reactions that have been carried out in the past and chemical substances that have been used. In addition, in research and development involving chemical reactions, we are also accumulating information on incidents that could lead to serious accidents (called near-miss incidents in Japan) and accident cases. Conventionally, such information is stored in an in-house database and referred to as needed. However, if an in-house information network is not sufficiently constructed, valuable information and know-how regarding the hazards of these chemical substances and chemical reactions cannot be effectively utilized for risk assessment.

As described above, the use of conventional chemical substance management systems is limited to specific tasks, and research and development involving chemical substances and chemical reactions cannot be made sufficiently efficient. Therefore, there is a demand for a risk assessment support system that improves the efficiency of research and development on chemical substances and chemical reactions through effective use of data and information associated with research and development.

A chemical substance and chemical reaction risk assessment support system according to one aspect of the present invention includes one or more databases storing multiple types of data and information related to research and development, and accesses the one or more databases to perform information processing. a management system; The one or more databases are information on current and past research and development, and contain research and development-related information including usage information of chemical substances in the current and past research and development, and chemical substance-related information on chemical substances. Store. The management system receives input of information indicating one or more chemical substances, and relates to the one or more chemical substances and chemical reactions of the one or more chemical substances based on the chemical substance related information and the research and development related information. Generate and output information to support risk assessment.

According to a representative example of the present invention, the effective use of data and information associated with research and development dealing with chemical substances and chemical reactions enhances the safety of experiments and work dealing with chemical substances and chemical reactions, and promotes research and development. efficiency can be improved.

1 is an overall configuration diagram of a chemical substance and chemical reaction risk evaluation support system in research and development; FIG. 1 is a diagram showing an outline of the flow of risk assessment of chemical substances and chemical reactions; FIG. It is a figure which shows the data stored in the database group of the said system. It is a figure which shows the data stored in the database group of the said system. It is a figure of the portal screen in a chemical substance and a chemical reaction risk-evaluation support system. This is a screen for inputting research information attached to experiments dealing with chemical substances and chemical reactions that are subject to risk assessment. It is a table showing an example of researcher information stored in a researcher information database. 4 is a table showing an example of research and development theme information stored in a research theme database; This is an input screen for chemical substances and chemical reactions for which risk assessment is to be performed. It is an input screen of the laboratory and experimental equipment which carry out a risk assessment. It is a table which shows an example of the information of the equipment of the laboratory stored in the laboratory information database. It is a table showing an example of asset information stored in an asset database. 4 is a table showing an example of experimental plan information stored in an experimental plan database; It is a table showing information about the contents of an arbitrary experimental protocol stored in the experimental protocol database. It is a figure which shows the information processing flow regarding the input of information required for risk evaluation. This is an input screen for collecting information necessary for risk assessment of chemical substances subject to risk assessment. This is a selection screen for information on a plurality of chemical substances. It is a user input screen regarding information required for risk assessment of chemical substances. It is a display screen of the detailed information regarding a chemical substance. It is a table showing an example of patent information stored in an in-house patent database. It is a table showing an example of research report information stored in a research report database. 4 is a table showing an example of externally announced information stored in an externally announced database; It is a figure which shows the information processing flow regarding the search of information required for risk assessment. FIG. 4 is a diagram showing an example (1) of SDS; FIG. 10 is a diagram showing an example (2) of SDS; FIG. 10 is a diagram showing an example (3) of SDS; FIG. 10 is a diagram showing an example (4) of SDS; It is a user input screen regarding risk assessment of chemical substances used as raw materials. 1 is a table relating to chemical hazard designation lists; It is a table regarding the hazard evaluation criteria of chemical substances. It is a figure which shows the information processing flow regarding evaluation of the physical chemical danger of a chemical substance. It is a table relating to classification information of physical and chemical hazards of chemical substances in GHS classification. It is a table related to classification information of health hazards in GHS classification. It is a table related to environmental hazard classification information in GHS classification. It is a table regarding the classification information of the dangerous substance in the Fire Service Act. It is a table regarding the classification information of dangerous goods in the Industrial Safety and Health Act. 4 is a table showing an example of near-miss and accident information stored in a near-miss and accident information database; 4 is a user input screen regarding risk assessment of chemical substances that are reaction products. 4 is a user input screen related to chemical reaction risk assessment. 1 is a table of hazard designation lists for combinations of chemicals; It is a table regarding the risk evaluation criteria of a chemical reaction. FIG. 4 is a diagram showing an information processing flow regarding chemical reaction risk assessment; 4 is a user input screen for laboratory, laboratory equipment and protective equipment safety assessment. FIG. 3 is a diagram showing an information processing flow regarding safety evaluation of a laboratory, experimental equipment, and protective equipment; It is a user input screen regarding the hazardous evaluation of a chemical substance. This is a user input screen regarding confirmation of laws and regulations to which chemical substances apply. It is a risk-assessment proposal output screen regarding confirmation and output of a risk-assessment proposal. FIG. 4 is a diagram showing an information processing flow regarding confirmation of laws and regulations to which a chemical substance applies and output of a risk assessment proposal; FIG. 10 is a user input screen regarding a request to perform risk assessment; FIG. 4 is a user input screen regarding acceptance of performing a risk assessment. It is a user input screen regarding approval of a risk assessment proposal. 4 is a user input screen for storing risk assessment proposals in a database. FIG. 10 is a diagram showing an information processing flow relating to requesting execution of risk evaluation, acceptance of execution of risk evaluation, approval of risk evaluation proposal, and storage of risk evaluation proposal in database.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. This embodiment is an experiment that handles chemical substances and chemical reactions by collecting data and information associated with research and development dealing with chemical substances and chemical reactions, and by effectively operating information such as association and analysis of collected data and information. Also, it relates to a research and development support system and application software that enhance work safety and improve research and development efficiency. Note that, hereinafter, research and development is also simply referred to as research.

Below is an example of the configuration of the chemical substance and chemical reaction risk assessment support system in research and development. FIG. 1 is an overall configuration diagram of a chemical substance and chemical reaction risk evaluation support system 101 (hereinafter abbreviated as risk evaluation support system) in research and development. The risk assessment support system 101 includes a management server (management system) 102 and a plurality of databases (DB) connected thereto. The database is stored in one or more storage devices within the risk assessment support system 101 . The type and number of databases may vary depending on system design, and the data structure of information stored in one or more databases may also vary depending on design. The risk assessment support system 101 can also be connected to one or more other systems to transfer data between the systems.

The above database group includes database groups 120 to 130 belonging to an organization (for example, a company). In addition to these, it is also possible to connect databases 111 outside the organization to the risk assessment support system 101 via the Internet connection 118 .

The system configuration of the management server 102 includes a network interface (I/F) 103, a processor 104 for calculation and control, a main memory 105, and an auxiliary memory 136, which can communicate via a bus. The number of these components is not limited. Main memory 105, auxiliary memory 136, or a combination thereof are storage devices that store programs and data.

Management server 102 may also include a search history database 106 for use in streamlining searches and making recommendations. In FIG. 1, the search history database 106 is stored in the auxiliary memory 136. FIG. Search history database 106 can also be configured to include a plurality of dedicated internal databases 107-110 to improve search efficiency.

The main memory 105 is composed of, for example, a semiconductor memory, and is mainly used to hold programs and data being executed. The processor 104 executes various processes according to programs stored in the main memory 105 . Various functional units are implemented by the processor 104 operating according to the program. Auxiliary storage 136 is composed of a large-capacity storage device such as a hard disk drive or solid state drive, and is used to store programs and data for a long period of time.

Processor 104 can be configured with a single processing unit or multiple processing units, and can include single or multiple computational units or multiple processing cores. Processor 104 is one or more central processing units, microprocessors, microcomputers, microcontrollers, digital signal processors, state machines, logic circuits, graphics processing units, chip-on-systems, and/or manipulates signals based on control instructions. Any device can be included.

Programs and data stored in the auxiliary memory 136 are loaded into the main memory 105 at startup or when necessary, and various processes of the management server 102 are executed by the processor 104 executing the programs. Therefore, the processing executed by the management server 102 below is processing by the processor 104 or a program.

Management server 102 connects to the network via I/F 103 . Management server 102 may further include input/output interfaces and input/output devices. The functions of the management server 102 can be implemented in a computer system comprising one or more computers including one or more processors and one or more storage devices including non-transitory storage media. Multiple computers communicate via a network. For example, some of the multiple functions of the management server 102 may be implemented in one computer, and others may be implemented in another computer.

The experiment protocol database 121 storing the contents of the risk assessment is a component of the risk assessment support system 101 and is connected to the management server 102 . In addition to the experiment plan database 121, the risk assessment support system 101 includes a researcher information database 122 that stores researcher information, a research theme database 123, an in-house patent database 124, and research report data as databases related to research and development. database 125 , public release database 126 , laboratory information database 127 , and asset database 128 . These databases are connected to the management server 102 .

The SDS database 120 of company's own products stores SDSs related to company's products among the data and information related to the safety of chemical substances required for risk assessment, and is connected to the management server 102 . For other companies' products, it is possible to search the SDS database 112 of other companies' products through the Internet connection 118 . The management server 102 can be connected to SDS databases of products of one or more companies. Other companies' products and SDS search histories of other companies' products can be accumulated in the SDS search history database 107 in the management server 102 in order to improve search efficiency.

Data and information on the dangers of chemical reactions are stored in a chemical reaction literature database 113 outside the company, and can be connected to the risk assessment support system 101 (management server 102) through an Internet connection 118. Furthermore, the management server 102 can obtain data from the research and development databases 121 to 128 connected within the risk assessment support system 101, the SDS database 120 of the company's products, and the SDS database 112 of other companies' products. A search history regarding the danger of chemical reactions can be accumulated in a chemical reaction search history database 108 in the management server 102 in order to improve search efficiency.

The near-miss and accident database 129 stores information on incidents (called near-miss in Japan) and accidents that may lead to accidents occurring within the organization, and is connected to the management server 102 . A database 114 storing similar information outside the company can be connected to the risk assessment support system 101 (management server 102) through an Internet connection 118. FIG. Search histories of near misses and accidents inside and outside the company can be accumulated in the search history database 109 of near misses and accidents in the management server 102 in order to improve search efficiency.

The in-house rules and standards database 130 includes information on safe handling of chemical substances and conduct of chemical reaction experiments, and is connected to the management server 102 . Furthermore, it is possible to connect a plurality of databases to the risk assessment support system 101 (management server 102) through the Internet connection 118 as external databases relating to the handling of chemical substances and chemical reactions. Examples of these external databases include a self-regulatory database 115 of trade associations, a database of domestic laws and regulations 116 , and a database of overseas laws and regulations 117 .

The risk assessment support system 101 can further include or be connected to a reagent management system 132 for inventory management of chemical substances in the research and development department and an ordering system 133 for ordering chemical substances.

The risk assessment support system 101 can also be connected to a chemical substance management system 134 that manages all chemical substances involved in research and development and manufacturing of products in the entire enterprise including the research and development department.

A part of the database included in or connected to the risk assessment support system 101 can be diverted from a database conventionally included in a system other than the risk assessment support system. For example, the SDS database 120 of the company's own products and the company rules and standards database 130 can utilize the database connected to the chemical substance management system 134 . If the chemical substance management system 134 has a system configuration that can be connected to the external self-regulatory database 115 of the trade association, the domestic related law database 116, and the overseas related law database 117 through Internet connection, risk assessment support System 101 (management server 102) can connect to these databases via chemical substance management system 134. FIG.

The risk assessment support system 101 can include a client terminal 131 such as a personal computer (PC) or a tablet terminal as input and output means. The client terminal 131 can communicate with the management server 102 via a network.

The client terminal 131 includes a processor, a program executed by the processor, a storage device for storing data thereof, and an interface connected to a network. At least part of the program and storage device can be provided not only inside the client terminal 131 but also at another location via a network. The client terminal 131 can include, for example, a mouse, keyboard, and/or touch panel as input devices, and a display device and/or printer as output devices.

FIG. 2 is a diagram showing an outline of the flow of risk assessment of chemical substances and chemical reactions. The risk assessment consists of four major categories, each of which is further divided into subcategories. Risk assessment is carried out in the order of the numbers assigned to the middle items in the figure, but middle items 3-1, 4-1, and 4-2 can be omitted depending on the situation. Also, if necessary, it is possible to perform a set of the intermediate items 2-1 and 2-2 a plurality of times. In the process of performing risk assessment, it is possible to interrupt the assessment according to various situations, or to return to the middle item already performed and perform the risk assessment again from there.

It is desirable that the draft risk assessment be prepared by a researcher who handles chemical substances to be assessed and conducts chemical reactions. The reason for this is that safer research and development can be carried out if the person who actually conducts the experiment understands the dangers of the chemical substances and chemical reactions to be handled. If the draft risk assessment draft is different from the actual experimenter, it is desirable for the person in charge of the experiment work to draft the risk assessment draft for similar reasons.

An outline of the flow of risk assessment will be described below in order. The first of the major items is the creation of a risk assessment plan, which is divided into six medium items. The order and contents of the middle items are as follows. Input of chemical substances and chemical reactions required for risk assessment (1-1), collection of information on said chemical substances and chemical reactions (1-2), risk assessment of said chemical substances and chemical reactions (1-3), Hazard evaluation of the chemical substance (1-4), confirmation of laws and regulations to which the chemical substance is applicable (1-5), and output of the risk assessment draft (1-6).

In this specification, the hazards of chemical substances mean the hazards based on the physical and chemical properties of the chemical substance. The danger of chemical reactions means the potential danger of causing dangerous phenomena such as explosions and fires that are difficult to control due to the coexistence of multiple chemical substances. Toxicity of a chemical substance means the hazard that the chemical substance exerts on the human body or the environment. In experiments involving chemical reactions, in addition to the conventional risk assessment of the hazards and hazards of chemical substances, thorough examination of the hazards of chemical reactions in advance can further improve safety.

The second major item is the deliberation and approval of the risk assessment draft created in major item 1. Deliberation of the draft assessment (2-1), approval of the draft assessment (2-2), and submission of the risk assessment results to the database. It is divided into three middle items of storage (2-3). Middle item 2-3 stores the risk assessment results approved in middle item 2-2 in experiment protocol database 121. FIG.

As described above, depending on the situation, it is possible to conduct a set of two intermediate items, deliberation of the evaluation plan (2-1) and approval of the evaluation plan (2-2), multiple times.

The third major item is the connection between the risk assessment support system 101 and other systems, and consists of one medium item. When the risk assessment support system 101 is connected to the reagent management system 132, whether or not the chemical substance to be used described in the approved risk assessment content exists in the storage location of the department conducting the chemical reaction experiment; If present, it is possible to ascertain how much of the chemical is present. Furthermore, it is possible to confirm the upper limit of the storage amount of the chemical substance that is permitted in the department that conducts the chemical reaction experiment.

When the risk assessment support system 101 is connected to the ordering system 133, the name of a reagent manufacturer that can be purchased when there is no inventory or the amount of the chemical substance described in the approved risk assessment content is insufficient. , delivery date, price, etc. can be obtained. Based on this information, it is also possible to use the ordering system 133 to order the necessary chemicals.

In general, companies in the manufacturing industry often introduce a chemical substance management system 134 that centrally manages the chemical substances they handle in all corporate activity stages from product research and development to manufacturing and shipping. When the risk assessment support system 101 intended for the research and development department is connected to the company-wide chemical substance management system 134, the manufacturing department can know the risk information of the chemical substances related to the product. This has the advantage of facilitating safety management.

The fourth major item is addition of information to the risk assessment contents once stored in the experiment protocol database 121 . Major item 4 consists of two middle items. External information is added (4-2) related to the evaluation content acquired from the database.

3 and 4 are diagrams showing the contents of data and information stored in each database connected to the risk assessment support system 101. FIG. 3 and 4 describe the data and contents of each database in sentences, and detailed descriptions in the specification are omitted. The database group can also store data or information other than the data and information described in FIGS.

In this embodiment, using the risk assessment support system 101, in research and development dealing with chemical substances and chemical reactions, among the risk assessments to be carried out in advance, An example of middle item 1-1 “input of chemical substances and chemical reactions required for risk assessment” is shown.

FIG. 5 is an example of a portal screen 501 in the risk assessment support system 101. As shown in FIG. The management server 102 generates such data for the portal screen 501 and transmits the data to the client terminals 131 such as personal computers and tablet terminals of researchers and administrators connected to the risk assessment support system 101 . The client terminal 131 displays a portal screen 501. FIG. The screen 501 serves as a user interface for researchers and administrators to search the system.

From the portal screen 501, researchers and administrators can proceed to screens for tasks such as creating risk assessment proposals, deliberating and approving assessments, linking with other systems, adding information to risk assessment details, searching, etc. is. Note that part of the display information on the portal screen 501 shown in FIG. 5 may be omitted. It is also possible to employ display formats different from those described below.

The portal screen 501 can display the affiliation 502 of the user, the user name 503 and the user ID number 504 based on the information of the user who logged in to the risk assessment support system 101 .

The risk assessment plan creation area 531 includes a button 505 for reusing the risk assessment plan created in the past, a button 506 for creating a new one, a button 507 for temporarily saving the risk assessment plan being created, and a button 507 for temporarily saving the risk assessment plan being created. It includes a button 508 to start applying for evaluation of a risk evaluation proposal and a button 509 to pull back a risk evaluation proposal for which evaluation has already been applied. The user who created the risk assessment proposal can use these buttons to perform desired operations. Also, when the preparation of evaluation proposals is started, each evaluation proposal is given a receipt number 510 and can be displayed on the portal screen 501 .

Next, an example will be described in which the deliberation and approval of the risk assessment proposal are evaluated in two stages, primary evaluation and secondary evaluation. The risk assessment proposal discussion and approval area 532 includes a button 511 for displaying a screen showing the risk assessment proposal under evaluation, a button 512 for displaying the rejected or rejected risk evaluation proposal, and an approved evaluation. A button 513 may be included that presents an idea. In FIG. 5, each of the primary evaluation buttons is designated by a code as an example. The number of stages of deliberation and approval of the risk assessment proposal is not limited to two stages and can be set arbitrarily. To register the finally approved risk assessment plan, use a button 514 for displaying a screen showing cases in the registration process and a button 515 for displaying a screen showing cases whose registration has been completed.

After the risk assessment is completed, the data can be federated with other systems for the chemicals included in the risk assessment. The collaboration with other systems area 533 can include buttons 520-522. A button 520 is for linking to the reagent management system 132 that manages inventory of chemicals in the research and development department. A button 521 is for linking to the ordering system 133 for ordering chemical substances. The button 522 is for linking to the chemical substance management system 134 that manages all chemical substances related to research and development and manufacturing of products in the entire company including the research and development department.

On the portal screen 501, after the risk evaluation is completed, the user can add information obtained from the experiment and information related to the content of the evaluation to the registered risk evaluation results. The additional information area 534 to the risk assessment content can include a button 516 for transitioning to a screen for adding experimentally obtained data to the registered risk assessment.

On the portal screen 501, the user can search for the contents of the risk assessment. In the search area 535, the portal screen 501 can display a window 523 for entering a search word, a search start button 524, and a window 525 for outputting a list output as the search result.

Next, an example of creating a new risk assessment plan will be described. FIG. 6 is an example of an input screen 601 of research information linked to the risk assessment for an experiment that handles chemical substances and chemical reactions that are subject to risk assessment. The research information input screen 601 is generated by the management server 102 . When the user clicks a past data reuse button 505 or a new creation button 506 on the portal screen 501 shown in FIG. 5, the display screen can transition from the portal screen 501 to the research information input screen 601.

When the input screen 601 is displayed, the management server 102 automatically inputs the risk assessment proposal creation date 604 and the risk assessment proposal receipt number 605 . In addition, a department name 606, a user ID number 607, and a user name 608 are automatically entered for the user who created the risk assessment proposal. In addition, the user can select the research number 609 that the user who performs the risk assessment this time is conducting from a plurality of candidates presented on the input screen 601 . When the research number 609 is selected, the research theme name 610 of the research number is automatically entered.

In research and development, a plurality of experiments are conducted for one research theme, and each experiment is often given a unique experimental theme name. Therefore, the name 611 of the experiment theme can be input by the user himself/herself using an input device attached to the client terminal 131 . If the theme names of the experiments to be carried out have already been created as electronic information in the experiment plan for the research theme, the management server 102 can automatically input those theme names.

After completing the input of the research information attached to the experiment, the user can register the contents with the registration button 603 . When temporarily interrupting the input, the user can use the temporary save button 602 to save the content of the input so far. The input contents are registered or temporarily stored in the experiment protocol database 121 .

A database group used when acquiring information displayed on the input screen 601 and information stored in the database group will be described. FIG. 7 is a diagram showing an example of researcher information 701 stored in the researcher information database 122 in the risk assessment support system 101. As shown in FIG. The researcher information 701 includes a researcher ID number 702 unique to the researcher, the researcher's name 703, the researcher's affiliation 704, the researcher's title 705, and the researcher's specialty 706. FIG.

FIG. 8 is a diagram showing an example of information 801 on research and development themes within the organization stored in the research theme database 123 in the risk assessment support system 101. As shown in FIG. The information 801 on the research and development theme includes a client number 802 indicating a project that requested research and development or a related business, a research number 803 unique to the research and development theme, a research and development theme name 804, a research period 805 of the research and development theme, Research budget 806, researcher name 807 and researcher ID number 808 engaged in the research and development theme are included. Information 809 regarding the progress of research and development at a specific date and time can be added to the above information.

Next, the user inputs chemical substances and chemical reactions to be subjected to risk assessment. FIG. 9 is an example of an input screen 901 for chemical substances and chemical reactions. The chemical substance and chemical reaction input screen 901 is generated by the management server 102 . The user can use a temporary save button 902 and a register button 903 on the input screen 901 to temporarily save or register the input content. The input contents are registered or temporarily stored in the experiment protocol database 121 .

The user himself/herself can input chemical substances to be subjected to risk assessment from the client terminal 131 . Since a plurality of chemical reactions are often performed in sequence in one experiment, the user first inputs the order of the chemical reactions in the input window 904 . The user can then enter the chemicals to be used in the chemical reaction. For example, for a substance that is a raw material for a chemical reaction, input the role (or use) in the chemical reaction from the input window 911, the name or abbreviation of the chemical substance from the input window 921, and either the composition formula or the structural formula of the chemical substance. Enter the chemical formulas in the input windows 931, respectively.

The user can similarly enter other chemicals involved in the chemical reaction. On the input screen 901, input windows 911 to 916 indicate the role of each chemical substance in the chemical reaction, input windows 921 to 926 indicate the name of each chemical substance, and input windows 931 to 936 indicate the chemical formula of each chemical substance. In the example of FIG. 9, the chemical substances obtained as a result of the chemical reaction are the main product which is the original target of the chemical reaction and the by-product which is a by-product. Depending on the chemical reaction, there may be multiple by-products or no by-products.

A chemical reaction also uses additives such as a solvent for dissolving the raw materials and reaction products, and a catalyst for activating the chemical reaction, and the user inputs these in the same way. Since solvents and additives do not directly undergo chemical reactions, the user inputs other chemical substances in the input window 905 instead of the order of chemical reactions.

Furthermore, for the chemical substances involved in the chemical reaction, the user collectively inputs the molecular weight of each chemical substance and the number of moles used in the experiment in Table 937 . The management server 102 can automatically calculate the weight or volume used in the chemical reaction for each chemical substance from the input molecular weight and number of moles, and display it on the client terminal 131 .

In a chemical reaction, in addition to multiple chemical substances that serve as raw materials, main products, by-products, and additives are mixed in the solvent. When a plurality of different chemical substances are mixed, depending on the combination of chemical substances, there is a risk of explosion or rapid heat generation. For this reason, it is important to conduct risk assessments not only for chemical substances used as raw materials, but also for all chemical substances involved in chemical reactions.

When inputting a chemical substance to be subjected to risk assessment, if a chemical reaction using a similar chemical substance has been performed in the past, the past risk assessment plan stored in the experiment protocol database 121 Of the contents, it is possible to copy and use the part of the input contents of chemical substances. At this time, the user uses the past data reuse button 505 in the risk assessment plan creation area 531 on the portal screen of FIG.

Next, enter the information on the chemical substance subject to risk assessment, the laboratory where the chemical reaction is performed, and the experimental equipment. FIG. 10 is an example of an input screen 1001 for laboratory and experimental equipment. The input screen 1001 for laboratory and laboratory equipment is generated by the management server 102 . On the input screen 1001, a temporary storage button 1002 and a registration button 1003 can be used to temporarily store or register the input content. The input contents are registered or temporarily stored in the experiment protocol database 121 .

The user selects a chemical substance and a chemical reaction laboratory from among the laboratories displayed on the input screen 1001 , and inputs it in the window 1004 . The laboratory equipment selected at this time is automatically entered in the window 1005 . The user can select from a plurality of experimental devices for handling chemical substances and chemical reactions and input them in window 1006 . The specifications of the experimental apparatus selected at this time are automatically entered in window 1007 .

A database group used to acquire information displayed in windows 1005 and 1007 on the input screen 1001 and information stored in the database group will be described. FIG. 11 is a diagram showing an example of laboratory equipment information 1101 stored in the laboratory information database 127 in the risk assessment support system 101 . The equipment information 1101 includes a laboratory number 1102, a laboratory name 1103, a laboratory manager name 1104, a laboratory manager ID number 1105, and details 1106 of the equipment provided in the laboratory.

FIG. 12 is a diagram showing an example of equipment asset information 1201 stored in the asset database 128 in the risk assessment support system 101 . The asset information 1201 includes an asset number 1202, asset name 1203, asset manager name 1204, researcher ID number 1205, installation location 1206, date of purchase 1207, price on the book on a specific date (book price) 1208, manufacturer name 1209 of the device, device specifications 1210, and incidental information 1211 such as accessory information, device remodeling information, and inventory information.

Inputs relating to chemical substances, chemical reactions, laboratories, and experimental equipment can be stored in protocol database 121 by management server 102 in either temporary storage or registration status. FIG. 13 is a diagram showing an example of experimental plan information stored in the experimental plan database 121 in the risk assessment support system 101. As shown in FIG. The experiment plan information 1301 includes a research number 1302 linked to the experiment theme, a research theme name 1303, a researcher name 1304 engaged in the theme, an ID number 1305 of the researcher, and an experiment theme described in the experiment plan document 1306. Name 1307, acceptance number 1308 of the relevant experiment protocol, approval number 1309, and progress status 1310 indicating the process of preparation, application, examination, and approval of the experiment protocol.

FIG. 14 is a diagram showing information 1401 on the content of the protocol stored in the protocol database 121 in the risk assessment support system 101. As shown in FIG. The information 1401 on the content of the experiment protocol includes information related to the experiment theme, such as a research number 1402 , research theme name 1403 , researcher name 1404 , researcher ID number 1405 , affiliation 1406 , and experiment theme name 1407 . Further, the experimental protocol creation date 1408, receipt number 1409, approval date 1410, approval number 1411, evaluator information 1412 and 1413 can be included.

In addition to the above, the information 1401 on the contents of the experiment protocol includes the background and purpose of the experiment (1470), the outline of the implementation contents (1471), and the contents of the chemical substances and chemical reactions used and the risk assessment (1472). . The detailed contents of the risk assessment include chemical substances used in experiments and details of chemical reactions to be performed (1414-1417). In addition to the role, name, and chemical formula of the chemical substance acquired on the input screen 901, the CAS registration number (abbreviated as CAS number), which is a unique number for each chemical substance, is entered for each chemical substance that is a raw material and a chemical substance that is a reaction product. ) can be included at 1415 and 1416, respectively. Furthermore, although not explicitly shown in the figure, it is also possible to describe chemical substances such as solvents and additives involved in the reaction. A description of the chemical reactions performed in the experiment can be described in Section 1417.

Furthermore, the information 1401 on the content of the experimental protocol includes information on the laboratory and experimental equipment to be used (1420-1422), risk assessment details of chemical substances and chemical reactions (1430-1435), harmfulness of raw materials and reaction products Contents of property evaluation (1440 to 1442) and contents 1450 of laws and regulations applicable to chemical substances used in experiments can be included. Knowledge and literature information obtained after conducting an experiment can also be included as postscript information 1460 .

Next, in creating a risk assessment proposal, an experiment theme and related information input screen 601 (FIG. 6), a chemical substance and chemical reaction input screen 901 (FIG. 9), and a laboratory and experimental apparatus input screen 1001 (FIG. 10) will be described with reference to the information processing flow of FIG.

First, the user inputs user identification information, such as a user ID number, on the client terminal 131 and logs into the risk assessment support system 101 . At this time, the management server 102 of the risk assessment support system 101 acquires the user ID number from the client terminal 131, searches the researcher information database 122, and searches for the researcher ID number and researcher name that match the user ID number. , affiliation is acquired (1501).

When the user clicks the new creation button 506 or the past data reuse button 505 in the risk assessment proposal creation area 531 on the portal screen 501 (FIG. 5), the display screen changes from the portal screen 501 to the research information attached to the experiment. The screen transitions to the input screen 601 . At this time, the management server 102 searches the research theme database 123 and acquires information regarding the presence or absence of a research theme, including the user ID number. If the corresponding theme does not exist (1502: NO), the management server 102 can display that effect and prompt the user to re-input (1503). If re-input is performed (1503: YES), the information processing flow returns to step 1501, and if re-input is not performed (1503: NO), the information processing flow ends.

If there is a corresponding theme (1502: YES), the management server 102 acquires date information, displays the information on the input screen 601 (1504), generates a risk assessment proposal receipt number, and The number is displayed on the input screen 601 (1505), a list of research numbers is created for research themes including the user ID number (1506), and the list is displayed on the input screen 601 (1507).

When the user selects one research number from the list of research numbers from the client terminal 131, the management server 102 acquires it (1508), and the name of the research theme linked to the research number is displayed on the input screen 601. Display (1509). Subsequently, the user inputs an experiment theme name from the client terminal 131, and the management server 102 acquires it and displays it on the input screen 601 (1510).

Subsequently, on the chemical substance and chemical reaction input screen 901, the user uses the client terminal 131 to register a plurality of chemical substances to be used in the experiment. When the past data reuse button 505 is selected, the management server 102 acquires and displays the past experiment plan of the selected research number from the experiment plan database 121, for example, and displays the experiment selected by the user. The information on the chemical substances in the plan is displayed on the input screen 901 . The user can change the displayed content. When the new creation button 506 is selected, the input window for the chemical substance on the input screen 901 is blank.

The user inputs the target chemical reaction order, and the management server 102 acquires the input information and displays the chemical reaction order on the input screen 901 (1511). For each chemical substance, the user inputs a chemical formula consisting of a role or use in a chemical reaction, a name or abbreviation, a compositional formula or a structural formula. The management server 102 acquires the input information and displays it on the chemical substance and chemical reaction input screen 901 (1512).

Next, the user inputs the molecular weight and the usage amount in moles of the chemical substance from the client terminal 131 . The management server 102 acquires the input information and displays it on the chemical substance and chemical reaction input screen 901 (1513). Subsequently, the management server 102 calculates the weight or volume of each chemical substance from the input molecular weight and usage amount of each chemical substance, and outputs it to the input screen 901 (1514).

Next, the management server 102 accesses the laboratory information database 127 and outputs a laboratory list on the input screen 1001 for laboratory and experimental apparatus (1515). The list can include laboratory numbers, laboratory names, and information on the equipment that the laboratory has. When the user selects a desired laboratory name from the client terminal 131, the management server 102 acquires the information (1516) and outputs the information of the equipment provided in the laboratory (1517).

Next, the management server 102 accesses the property database 128 and outputs a list of the experimental devices belonging to the selected laboratory on the laboratory and experimental device input screen 1001 (1518). When the user selects an experimental device to be used from the list of experimental devices from the client terminal 131, the management server 102 acquires the name of the experimental device (1519) and outputs the specifications of the equipment (1520).

As described above, this embodiment makes it possible to easily input necessary data and information without increasing the burden on researchers who are actually working in the risk assessment of chemical substances and chemical reactions. Improve the efficiency of research and development on materials and chemical reactions.

In this embodiment, using the risk assessment support system 101, in research and development dealing with chemical substances and chemical reactions, among the risk assessments to be carried out in advance, An example of medium item 1-2 “Collection of information on chemical substances and chemical reactions” will be explained.

FIG. 16 is a diagram showing an example of a screen 1601 for collecting information necessary for risk assessment of chemical substances input on the input screen 901 described above. On the input screen 1601, a temporary save button 1602 and a register button 1603 can be used to temporarily save or register the input content. The input contents are registered or temporarily stored in the experiment protocol database 121 .

When the user clicks the data read button 1606 on the input screen 1601, the management server 102 displays the role (or application), name, and chemical formula information of the chemical substance obtained on the input screen 901 in the area 1604. It is possible to If the history of the input chemical substance used in experiments in the past exists in the experiment protocol database 121 , the management server 102 can automatically display the CAS number of the chemical substance in the area 1605 . If there is no history of use in the past, the management server 102 can request the user to enter the CAS number of the chemical substance. At this time, the user can input the CAS number of the chemical substance from the client terminal 131 and the management server 102 can display the CAS number in the area 1605 .

Chemical substances, especially organic compounds, have structural isomers that have the same chemical composition but different atomic arrangements and bonding positions. A different CAS number is assigned to each structural isomer. Therefore, when there are multiple structural isomers corresponding to the input chemical formula, the user can select a chemical substance having a specific structure using the CAS number. In this case, an information selection screen 1701 illustrated in FIG. 17 can be used. On the information selection screen (input screen) 1701, a temporary storage button 1702 and a registration button 1703 can be used to temporarily store or register the input content. The input contents are registered or temporarily stored in the experiment protocol database 121 . The user selects a desired chemical substance in area 1706 from the candidate substances displayed in area 1705 according to the content displayed in message area 1704 . Other display methods are also possible.

Next, when the user clicks the search button 1607, the management server 102 can acquire the safety data sheet (hereinafter abbreviated as SDS) of each chemical substance based on the acquired CAS number. SDS is a document that contains information on the properties and handling of chemical substances. Issued by businesses that provide products containing hazardous chemicals. Examples of SDS are shown in Figures 24-27.

For the SDS search, the SDS search history database 107 in the management server 102, the SDS database 120 of the company's products, and the SDS database 112 of other companies' products connected to the risk assessment support system 101 via the Internet can be used. It is possible. Each SDS database stores the SDS illustrated in FIGS. 24-27 for each chemical substance.

As a result of the above search, if an SDS matching the CAS number is found in the databases of multiple business operators, the management server 102 can acquire the SDS of a specific business operator specified by the user. .

If no SDS matching the CAS number is found for a specific chemical substance, the user can enter information necessary for risk assessment from the client terminal 131 . At this time, the input screen 1801 in FIG. 18 can be used as an example of a screen for the user to input information necessary for risk assessment of chemical substances. As for the information input format, as shown in the input screen 1801, one that complies with the SDS format can be used.

Using the client terminal 131, the user enters the physical and chemical properties, stability and reactivity, toxicity, and environmental impact information of the chemical substance in the input areas 1804, 1810, 1820, and 1830, respectively, in accordance with the SDS format. fill in. Taking physicochemical properties as an example, the user inputs the contents obtained by actual measurement in academic papers, technical books, or preliminary experiments on predetermined items such as physical state, shape, and color in each item in area 1805 . You can fill in the fields. At that time, the information of the referenced document can be entered in the area 1806 . In addition, it is possible to enter the obtained remarks in area 1807 .

Input of stability and reactivity, hazard information, and environmental impact information can be performed in the same manner as described above. That is, the user can enter predetermined items in areas 1811, 1821 and 1831, references in areas 1812, 1822 and 1832, and special notes in areas 1813, 1823 and 1833, respectively.

For the chemical substance for which the CAS number has been acquired, the management server 102 stores the manufacturer name 1611, product number 1612, SDS information 1613, past usage history 1614, and whether or not the chemical substance is possessed in the area 1610. inventory information 1615 can be displayed indicating the When acquiring inventory information, the reagent management system 132 or the chemical substance management system 134 that can be connected to the risk assessment support system 101 can be used.

Management server 102 can display in area 1620 information search results for chemical reactions scheduled to be performed. To search chemical reaction information, chemical reaction search history database 108, experiment plan database 121, research report database 125 in management server 102, and chemical reaction documents connected to risk assessment support system 101 via the Internet. A database 113 can be used. It is also possible to use databases other than these for searching. As a result of the search, management server 102 can display in area 1621 the presence or absence of information on the chemical reaction. Also, the user himself/herself can input information about the chemical reaction in area 1622 .

After completing the input of information on chemical substances and chemical reactions, the management server 102 can display detailed information as shown in FIG. Selecting the back button 1902 allows the user to return to the previous screen. The detailed information display screen 1901 displays detailed information on the SDS, usage history, inventory, and chemical reaction of the chemical substance for which detailed information display is specified in display areas 1903, 1910, 1920, and 1930, respectively. can be done.

The management server 102 can also display additional information about the chemical substance as recommended information in the detailed information. The management server 102 creates a recommendation model using an arbitrary algorithm or method, and when requested to display detailed information on a chemical substance, the management server 102 creates new data and information (attached data) associated with the chemical substance. information) can be displayed as recommendations. In preparation for creating recommendation information, the management server 102 can accumulate various search histories in the search history databases 107-110. The management server 102 can combine these search history databases and databases connected to the system and use them for recommendations.

In the example of FIG. 19, as recommended information on SDSs for chemical substances, if there are SDSs from multiple manufacturers, that fact is displayed in area 1904, and multiple manufacturers including the manufacturer selected in area 1903 are shown. .

In the example of FIG. 19, the name and researcher ID number of a researcher who used the chemical substance in the past are displayed in an area 1911 as recommendation information regarding the usage history of the chemical substance. Furthermore, information on research themes using the chemical substance, research reports resulting from the research, patents, and external publications are also displayed as recommendation information. These pieces of information can be obtained from the in-house patent database 124 , the research report database 125 , and the external presentation database 126 .

In addition, the management server 102 indicates in the area 1921 the existence of chemical substances having similar structures as recommendation information regarding chemical substance inventories. Information about chemical inventories can be obtained from reagent management system 132 or chemical management system 134 .

The management server 102 can display details of the information acquired about the chemical reaction in the area 1931 . Furthermore, it is possible to display recommended information regarding the chemical reaction in the area 1932 . If the accompanying information including the recommendation has more specific content, the user will be able to obtain more specific information regarding chemical substances and chemical reactions for which risk assessment is to be performed.

20, 21, and 22 are diagrams showing examples of information stored in the in-house patent database 124, research report database 125, and external presentation database 126, respectively, in the system.

FIG. 20 is an example of a table of information 2001 relating to internal patents. Including research theme 2006 and research number 2007, internal filing date of patent specification 2008, application number 2009 and filing date 2010. In addition to these, it is possible to add the publication number and publication date of the relevant application, and subsequent history regarding patent establishment (examination request or not, patent number, etc.).

FIG. 21 is an example of a table of information 2101 related to research reports, and includes a research report number 2102, report name 2103, researcher name 2104 and researcher ID number 2105 who are the reporter, and the source of the report. It includes research theme 2106 and research number 2107, date of report 2108, and keywords 2109 suggestive of the content of the report for searching. It is also possible to add information other than these.

FIG. 22 is an example of a table of information 2201 regarding external presentation. External presentations refer to the publication of research and development results outside the company in some form, such as oral or poster presentations at academic conferences, papers submitted to academic journals, article commentary in specialized journals, and news releases outside the company. The information table includes an in-house reference number 2202, a title 2203 of the presentation, etc., a presentation medium name 2204 such as the name of the academic conference or journal that made the presentation, the date of presentation 2205, the name of the researcher who made the presentation 2206 and the researcher ID number 2207, and the number of the publication outside the company. It includes the original research theme 2208 and research number 2209, and keywords 2210 related to the content of the external presentation for searching. It is also possible to add information other than these.

Next, an input screen 1601 (FIG. 16) for collecting information on chemical substances, an information selection screen 1701 (FIG. 17) for information on a plurality of chemical substances, and a user input screen 1801 (FIG. 17) for information necessary for risk assessment of chemical substances. 18) and a method of acquiring information displayed on the display screen 1901 (FIG. 19) for detailed information on chemical substances will be described with reference to the information processing flow diagram of FIG.

When the user clicks the data read button 1606, the management server 102 of the risk assessment support system 101 inputs information on the chemical formula, name, role (or application) of the chemical substance subject to risk assessment acquired on the input screen 901. It is displayed in area 1604 of screen 1601 (2301).

Next, the management server 102 searches the experiment protocol database 121 using the already acquired chemical formula or name of the chemical substance as a keyword, and acquires information on the usage history of the chemical substance (2302). At this time, the management server 102 also obtains the CAS number of the chemical substance from the experiment protocol database 121 . Examples of the CAS numbers described in the experiment protocol include information 1415 on raw chemical substances and information 1416 on reaction products in the information 1401 on the content of the experiment protocol.

If the use history of the chemical substance does not exist (2302: NO), the management server 102 displays a message requesting the user to enter the CAS number of the chemical substance (2303). Subsequently, the management server 102 obtains the CAS number entered by the user and displays it in the area 1605 of the screen 1601 (2306).

If there is a usage history of the chemical substance (2302: YES), the management server 102 confirms whether or not the chemical substance has a structural isomer or a similar structure in the same chemical formula (2304). If there is a structural isomer or similar structure of the chemical substance (2304: YES), the management server 102 sends a message requesting the user to select the desired chemical substance from multiple candidates using the CAS number ( 17) is displayed (2305), and the CAS number of the designated chemical substance is acquired and displayed in area 1605 of screen 1601 (2306). If there is no structural isomer or similar structure (2305: NO), the CAS number obtained as it is is displayed (2306). At the same time, it is also possible to display the status of whether or not there is a usage history in area 1614 .

Next, when the user clicks the search button 1607, the management server 102 accesses a plurality of databases based on the entered CAS numbers of the plurality of chemical substances and obtains SDSs that match the CAS numbers (2307). . For the SDS search, the SDS search history database 107 in the management server 102, the SDS database 120 of the company's products, and the SDS database 112 of other companies' products connected to the risk assessment support system 101 via the Internet can be used. It is possible.

If an SDS that matches the CAS number does not exist in any of the above databases (2307: NO), the management server 102 prompts the input of information on the same level as the SDS description for chemical substances for which the SDS does not exist. A display requesting the user (FIG. 18) is performed (2308). Next, the management server 102 acquires the necessary information input by the user from the client terminal 131, and displays information indicating that there is no SDS in the area 1613 (2309).

If an SDS that matches the CAS number exists in any of the above databases (2307: YES), the management server 102 checks that the SDS provided by multiple companies for the same CAS number for the chemical substance for which the SDS exists. Check if it exists (2310). If there are multiple SDSs (2310: YES), the management server 102 displays a request for the user to select a specific SDS from multiple SDSs (2311), and acquires the SDS specified by the user (2312). ). At the same time, the management server 102 can display the maker name 1611, product number 1612, and SDS existence status 1613 that issued the acquired SDS. If there is only one SDS (2310: NO), the management server 102 acquires the corresponding SDS and displays the same as above (2312).

Next, the management server 102 acquires chemical substance inventory information used for risk assessment and displays the information in the area 1615 of the screen 1601 (2313). The management server 102 can acquire inventory information of the chemical substance via the reagent management system 132 or the chemical substance management system 134 .

Next, the management server 102 collects information on chemical reactions from the chemical reaction search history database 108, the experiment plan database 121, the research report database 125, the chemical reaction literature database 113, etc. Displayed at 1620 (2314). At this time, if there is no appropriate information on the chemical reaction in the database group, it is possible to use the information that the user has entered in area 1622 on the chemical reaction. The management server 102 can display detailed information of chemical substances for risk assessment. If the management server 102 displays the inquiry to the user (2315) and the user does not request display of detailed information (2315: NO), the flow ends. When the display of detailed information is requested by the user (2315: YES), the management server 102 searches for the presence or absence of accompanying information on the chemical substance (2316). Accompanying information refers to recommendation information associated with the chemical substance created by the management server 102 according to the recommendation model.

If there is accompanying information about the chemical substance (2316: YES), the management server 102 extracts the corresponding accompanying information (2317), and combines it with the information on the SDS, the usage history of the chemical substance, and the detailed information on inventory. are displayed in display areas 1903, 1910 and 1920, respectively (2318). If there is no accompanying information (2316: NO), detailed information is output.

As described above, this embodiment makes it possible to easily obtain necessary data and information without increasing the burden on researchers who are actually working in the risk assessment of chemical substances and chemical reactions. , improve the efficiency of research and development on chemicals and chemical reactions.

In this example, in the middle item 1-3 "Risk assessment of chemical substances and chemical reactions" in major item 1 "Preparation of risk assessment proposal" shown in FIG. An example is explained.

First, the risk assessment of chemical substances that are raw materials for chemical reactions will be described. FIG. 28 is a diagram showing an example of a screen relating to risk assessment of chemical substances used as raw materials, solvents for chemical reactions, and additives among chemical substances for which SDSs have been obtained on the input screen 1601 described above. On this input screen, a temporary storage button 2802 and a registration button 2803 can be used to temporarily store or register the input content. The input contents are registered or temporarily stored in the experiment protocol database 121 .

When the user clicks the data read button 2804 on the input screen 2801, the management server 102 reads the name, chemical formula, role (or use), CAS number, manufacturer name, and product of the chemical substance acquired on the input screen 1601 above. Information regarding numbers, SDS, usage history, and inventory can be displayed in area 2805 .

Next, the management server 102 can extract information 2401 on physical and chemical hazards regarding the chemical substance from the SDS of these chemical substances, and display the content in the area 2806 . SDSs are often provided in PDF format. Extraction of this information from PDF format files can apply text search and extraction techniques that can extract relevant portions.

The management server 102 uses a chemical substance hazard specification list 2901, an example of which is shown in FIG. , can be displayed in area 2807 . The chemical substance hazard designation list 2901 can be arbitrarily formulated by the research and development department that handles chemical substances and chemical reactions, and is stored in the company rules and standards database 130, for example.

Fig. 29 shows an example created based on the physical and chemical hazard classes in the United Nations GHS classification, Japanese Fire Service Law hazardous materials, and Japanese Industrial Safety and Health Act Appendix Table 1. . Other standards and laws may be applied to the preparation of the list.

FIG. 32A shows a table 3201 relating to classification information of physical and chemical hazards in UN GHS classification, FIG. 32B shows a table 3202 relating to classification information of health hazards in GHS classification, and FIG. 3203 shows a table 3203 relating to classification information of harmfulness to . FIG. 33 shows a table 3301 relating to the classification information of dangerous substances under the Japanese Fire Service Law, and FIG. 34 shows a table 3401 relating to the classification information of dangerous substances (Appended Table 1) under the Japanese Industrial Safety and Health Law.

As in the example above, by performing an assessment based on a chemical substance hazard designation list that has been prepared in advance, it is possible to reduce variations in the risk assessment content for each user, resulting in a high-quality risk assessment. It can be performed.

Next, we conduct a risk assessment of chemical substances that are raw materials for chemical reactions. FIG. 30 is a diagram showing an example of risk evaluation criteria for chemical substances. Using the evaluation criteria 3001, the management server 102 determines whether or not the chemical substance can be used based on the physical and chemical hazards of the raw chemical substance and the related chemical substance such as the solvent displayed in the area 2807. It is possible to evaluate comprehensively and display the results in area 2810 . Note that the evaluation criteria 3001 described above are just an example, and can be arbitrarily formulated by the research and development department that handles chemical substances and chemical reactions, and are stored in the company rules and criteria database 130, for example.

When the evaluation result indicates that the evaluation is canceled due to lack of information (level 4), the user obtains data or information necessary for evaluation of the chemical substance for which information is insufficient, for example, through experiments or calculations. The user can add the data or information obtained in this way and carry out the risk assessment again.

The management server 102 creates a model for recommendation in advance using an arbitrary algorithm or method for the risk assessment results of chemical substances that are raw materials for chemical reactions, and creates new data and information associated with the chemical substance ( accompanying information) can be displayed as a recommendation. In FIG. 28, as the recommendation information 2811, an accident case regarding a specific chemical substance is displayed. If the recommendation information has more specific content, the user will be able to evaluate the risk of chemical substances and chemical reactions for risk assessment based on more abundant information.

In creating recommendation information, the management server 102 can create recommendation information by combining the search history database 106, the in-house near-miss and accident database 129, and the external near-miss and accident database 114. It is also possible to combine databases other than these.

FIG. 35 is an example of a table 3501 of information stored in the near-miss and accident database 114 outside the company. include. It is also possible to add information other than these. The in-house near-miss and incident database 129 can also store similarly structured tables.

Research and development departments sometimes handle chemical substances that do not have sufficient information about their hazards, and it may be necessary for users themselves to consider the hazards of chemical substances based on the collected information. Therefore, in one example, the user writes in area 2812 the findings of the user who creates the assessment proposal in the risk assessment of chemical substances that are raw materials for chemical reactions. At this time, in addition to the physicochemical hazards of the chemical substance described in area 2401 of the SDS, the user can also determine the physical and chemical properties and stability reactivity of the chemical substance described in areas 2602 and 2603. It is possible to refer to information about

Next, a method of acquiring information displayed on the screen 2801 regarding risk assessment of chemical substances used as raw materials, solvents for chemical reactions, and additives will be described using the information processing flow diagram of FIG. 31 .

When the user clicks the data read button 2804, the management server 102 of the risk assessment support system 101 reads the chemical formula, name, role (or application), and CAS number of the chemical substance subject to risk assessment acquired on the input screen 1601. , and SDS are displayed in the area 2805 of the input screen 2801 (3101).

Next, the management server 102 extracts the physical and chemical hazards of the chemical substance from the corresponding parts of the acquired SDS and displays them in the area 2806 (3102). The management server 102 compares the obtained extracted contents with the chemical substance risk designation list 2901 to determine the risk of the chemical substance and displays it in the area 2807 (3103).

Next, the management server 102 uses the evaluation criteria 3001 to perform a comprehensive risk evaluation regarding the propriety of using chemical substances that are raw materials for chemical reactions, and displays the results in an area 2810. (3104).

If the evaluation result is discontinued (3105: YES), the management server 102 confirms the reason for discontinuing the evaluation. Then, after adding the missing data, a display prompting the risk evaluation is displayed again (3107).

If the reason for discontinuation is not lack of information (3106: NO), it means that the prohibited chemical substance described in the above-mentioned risk designation list is included, so the management server 102 displays that fact to the user. (3108).

If the evaluation result is not cancellation (3105: NO), the management server 102 confirms the presence or absence of additional information regarding the risk evaluation (3109). If there is accompanying information related to the risk assessment (3109: YES), the management server 102 extracts the corresponding accompanying information and displays it in the area 2811 as a recommendation (3110). FIG. 28 displays, as an example of a recommendation, an accident case concerning a chemical substance to be used as an additive.

After the accompanying information is displayed (3110), or if the accompanying information does not exist (3109: NO), the management server 102 acquires the user's findings and displays them in the area 2812 (3111).

According to this embodiment, it is possible to keep the quality of the risk evaluation contents uniform when evaluating risks concerning chemical substances and chemical reactions, and to perform high-quality risk evaluations.

In this embodiment, in the middle item 1-3 "Risk assessment of chemical substances and chemical reactions" in major item 1 "Preparation of risk assessment proposal" shown in FIG. An example about is explained.

Reaction products obtained as a result of chemical reactions are also subjected to risk assessment in the same way as chemical substances used as raw materials. FIG. 36 is a diagram showing an example of a screen relating to risk assessment of reaction products among chemical substances for which SDSs have been acquired on the input screen 1601 described above. On the input screen 3601, a temporary save button 3602 and a register button 3603 can be used to temporarily save or register the input content. The input contents are registered or temporarily stored in the experiment protocol database 121 .

When the user clicks the data read button 3604 , the management server 102 can display the acquisition status of the information on the chemical substance acquired on the input screen 1601 in the area 3605 . In the case of a reaction product, the management server 102 can also display the status of the presence or absence of document information in the area 3608, assuming that there is no SDS.

Management server 102 extracts information on the physical and chemical hazards of the reaction product from area 2401 if there is an SDS, and if there is no SDS, the information entered by the user on screen 1804 is used to extract information from area 2401. 3606 can display its contents.

The management server 102 uses a chemical substance hazard designation list 2901, an example of which is shown in FIG. can be used to determine the danger of the chemical substance and display it in area 3607 .

Risk assessment of reaction products can also be carried out in the same manner as raw material chemical substances. Using the evaluation criteria 3001, the management server 102 comprehensively evaluates whether or not the chemical substance can be used based on the physical and chemical hazards of the reaction products, and displays the results in an area 3610. do.

When it is determined that the evaluation is canceled due to lack of information (level 4) as a result of the evaluation, for example, the user obtains the data or information necessary for the evaluation of the chemical substance for which the information is insufficient through experiments, calculations, or the like. The user can add the data or information obtained in this way and carry out the risk assessment again.

In the risk assessment result of a chemical substance, the management server 102 creates a model for recommendation using an arbitrary algorithm or method, and uses new data and information (accompanying information) associated with the chemical substance as a recommendation. It is possible to display In FIG. 36, as the recommendation information 3611, the use history of a specific chemical substance within the company is displayed.

In creating recommendation information, the management server 102 can create recommendation information by combining the search history databases 107 to 110, the in-house near-miss and accident database 129, and the external near-miss and accident database 114. . It is also possible to combine databases other than these. The recommendation information 3611 illustrated in FIG. 36 is created by combining the experiment protocol database 121 and the research report database 125 .

As in the case of raw chemical substances, the information processing flow regarding risk assessment of reaction products can be explained using FIG. 31, and the details are omitted.

According to this embodiment, it is possible to keep the quality of the risk evaluation contents uniform when evaluating risks concerning chemical substances and chemical reactions, and to perform high-quality risk evaluations.

In this embodiment, in the middle item 1-3 "Risk assessment of chemical substances and chemical reactions" in major item 1 "Preparation of risk assessment proposal" shown in FIG. Following the hazard assessment, an example of hazard assessment of chemical reactions involving those chemicals is described.

FIG. 37 shows a screen 3701 as an example of an input interface screen for chemical reaction risk assessment. On this screen, a temporary save button 3702 and a register button 3703 can be used to temporarily save or register the input content. The input contents are registered or temporarily stored in the experiment protocol database 121 .

When the user clicks the data read button 3704, the management server 102 can display the contents of the information on the chemical substances involved in the chemical reaction obtained on the input screens 1601, 2801 and 3601 in areas 3706 to 3709. can. In particular, areas 3708 and 3709 are for the physical and chemical hazard information (2806, 3606) and hazard designation information (2807, 2807, 3607) can be displayed. The management server 102 can display the content acquired on the input screen 1601 and displayed in the area 1620 in the area 3710 as literature information on the chemical reaction.

Based on their structures and properties, chemical substances are classified according to their physical and chemical hazards such as spontaneous combustibility and flammability in the GHS classifications shown in FIGS. 32A, 33 and 34 and other laws and regulations. The management server 102 designates hazards related to chemical reactions based on combinations of chemical substances having specific physical and chemical hazards. At this time, it is possible to use a risk designation list 3801 relating to combinations of highly dangerous chemical substances, an example of which is shown in FIG. Risk designation list 3801 is, for example, pre-formulated and stored in company rules and standards database 130 . The determination result is displayed in area 3711 by management server 102 .

The hazard designation list 3801 shown in FIG. 38 includes explosives that are the most reactive and require the utmost care in handling, as well as explosives classified as reactive chemicals, oxidizing substances, organic peroxides, and An example of a list of hazards in chemical reactions performed by combining chemical substances, focusing on self-reactive substances, is shown. The list can show contents other than this, and can be arbitrarily formulated by research and development departments that handle chemical substances and chemical reactions in light of their respective research and development contents.

As in the example above, by conducting an assessment based on a hazard designation list for a combination of chemical substances prepared in advance, it is possible to reduce the variation in risk assessment details for each user, and it is possible to improve the quality of the assessment. Conducts risk assessment.

Chemical reactions must always be carried out with due consideration for safety, taking into account the danger of explosions and fires. For this reason, accident information related to planned chemical reactions is also important when conducting risk assessments of chemical reactions. . The management server 102 uses the near-miss and accident search history database 109 included in the management server 102, the in-house near-miss and accident database 129, and the external database 114 to determine the chemical reaction subject to risk evaluation. search for incidents and accident cases. Search results are displayed in area 3720 .

Next, the management server 102 performs risk assessment for chemical reactions. FIG. 39 is a diagram showing an example of risk assessment criteria for chemical reactions. Using the evaluation criteria 3901, the management server 102 uses the risk of the chemical reaction displayed in the area 3711 and the risk of the chemical substances involved in the reaction displayed in the areas 3708 and 3709 to determine the chemical reaction. can be comprehensively evaluated, and the results can be displayed in area 3730 . The evaluation criteria 3901 are, for example, preformed and stored in the company rules and standards database 130 .

Since chemical reactions take place in an environment where multiple chemical substances coexist, in addition to the hazards of the chemical reaction itself, the physical and chemical hazards of each of the chemical substances involved in the chemical reaction must also be considered. Evaluation is important. Note that the evaluation criteria 3901 described above are merely an example, and can be arbitrarily established by research and development departments that deal with chemical substances and chemical reactions in light of their respective research and development contents.

As a result of the evaluation, if the evaluation is judged to be canceled due to lack of information (level 4), the user can obtain the data or information necessary for the evaluation of the chemical reaction for which the information is insufficient through experiments, calculations, etc. . The user can add the data or information obtained in this way and carry out the risk assessment again.

In the chemical reaction risk assessment results, the management server 102 creates a recommendation model using an arbitrary algorithm or method, and adds new data and information (associated information) associated with the chemical substance to the recommendation model. can be displayed as FIG. 37 displays the implementation history of similar chemical reactions as recommendation information 3731 .

Research and development departments sometimes handle chemical reactions that do not have sufficient information about hazards, so it is important for users themselves to consider the hazards of chemical reactions based on the collected information. For this reason, for example, the user writes in area 3740 the findings of the user who creates the evaluation proposal in the risk evaluation of chemical reactions.

A method of obtaining information displayed on the screen 3701 regarding chemical reaction risk assessment will be described with reference to the information processing flow diagram of FIG. When the user clicks the data read button 3704, the management server 102 of the risk assessment support system 101 sends the information on the chemical substances and chemical reactions to be subjected to the risk assessment acquired in the input screens 1601, 2801 and 3601 to the input screen 3701. are displayed in areas 3706 to 3710 of (4001).

Next, the management server 102 compares the information displayed in the areas 3708 and 3709 as the physical and chemical hazard classification of each chemical substance with the chemical reaction hazard designation list 3801 to determine the hazard of the chemical reaction. and displays the result in area 3711 (4002).

Management server 102 searches a plurality of databases for incidents and accident cases that may lead to accidents, and displays the results in area 3720 for chemical reactions to be evaluated (4003).

Next, the management server 102 uses the chemical reaction risk evaluation criteria 3901 to perform a comprehensive risk evaluation regarding whether or not the chemical reaction can be carried out, and displays the result in an area 3730 (4004).

If the evaluation result is discontinued (4005: YES), the management server 102 confirms the reason for discontinuing the evaluation. Then, after adding the missing data, a display prompting the risk evaluation is displayed again (4007).

If the reason for discontinuation is not lack of information (4006: NO), the combination of prohibited chemical substances (prohibited chemical reaction) listed in the above hazard designation list 3801 is included. The management server 102 displays that fact to the user (4008).

If the evaluation result is not cancellation (4005: NO), the management server 102 confirms the presence or absence of additional information related to the risk evaluation (4009). If there is accompanying information related to the risk assessment (4009: YES), the management server 102 extracts the relevant accompanying information and displays it in the area 3731 as a recommendation (4010). The screen example of FIG. 37 displays the implementation history of chemical reactions similar to the evaluation target as an example of recommendation.

After the accompanying information is displayed (4010), or if the accompanying information does not exist (4009: NO), the management server 102 acquires the user's findings and displays them in the area 3740 (4011).

According to this embodiment, it is possible to keep the quality of the risk evaluation contents uniform when evaluating risks concerning chemical substances and chemical reactions, and to perform high-quality risk evaluations.

In this embodiment, in the middle item 1-3 "Risk assessment of chemical substances and chemical reactions" in major item 1 "Preparation of risk assessment proposal" shown in FIG. An example of safety evaluation of the experimental site, experimental equipment, and protective equipment will be described with reference to FIG.

When the user presses a data read button 4104 on the input screen 4101, the information (1004 to 1007) of the laboratory and the experimental apparatus input on the screen 1001 can be displayed in areas 4111 to 4114, respectively. Next, the user refers to the information (2402, 2501, 2601) such as safety measures, first aid, exposure prevention and protective measures described in the SDS of each chemical substance used in the experiment, and the experimental equipment and Observations about the device can be noted in area 4115 .

Subsequently, the user can confirm the content of protective equipment used in the experiment in area 4120 . When the data read button 4104 is clicked, the management server 102 can extract the information on the protective equipment used in the experiment that handles chemical substances from the description content 2601 of the SDS and display it in the area 4121. . In addition, the user may make notes in area 4122 regarding protective equipment that is important when working with chemicals.

Areas 4110 and 4120 in the example of FIG. 41 do not describe risk evaluation results, but the management server 102 performs experiments on experimental facilities, experimental equipment, etc. based on predetermined evaluation criteria such as the risk evaluation of chemical substances and chemical reactions. and protective equipment risk assessment. In addition, the management server 102 creates a model for recommendation using an arbitrary algorithm or method, and new data and information ( Accompanying information) can also be displayed as a recommendation. As examples of recommendations, information 4116 associated with laboratories and example 4123 of information associated with protective equipment are shown.

In this way, in the risk assessment, it is possible to conduct experiments with higher safety by confirming the information on the equipment of the room, the specifications of the equipment, and the protective equipment used in the experiments using chemical substances.

Next, a method of acquiring information displayed on the screen 4101 regarding safety evaluation of the experiment location, experiment equipment, and protective equipment will be described using the information processing flow diagram of FIG. 42 .

When the user clicks the data read button 4104, the management server 102 of the risk assessment support system 101 displays the laboratory information acquired on the input screen 1001 in the areas 4111 and 4112 of the input screen 4101 (4201). Information about the experimental device is similarly obtained and displayed in areas 4113 and 4114 (4202). Subsequently, the management server 102 acquires the user's findings regarding the laboratory and the experimental apparatus and displays them in the area 4115 (4203).

Next, the management server 102 extracts the information on the object to be protected and protective equipment from the relevant portions (2402, 2501, 2601) of the SDS and displays it in the area 4121 (4204). Subsequently, the management server 102 acquires the user's findings regarding protective equipment and displays them in the area 4122 (4205). Finally, the management server 102 confirms the presence or absence of accompanying information regarding the laboratory, experimental equipment, and protective equipment (4206). If there is accompanying information (4206: YES), the management server 102 extracts the corresponding accompanying information and displays it in the recommendation areas 4116 and 4123 (4207). After the accompanying information is displayed, or if the accompanying information does not exist (4206: NO), the management server 102 terminates the process.

According to the present embodiment, it is possible to efficiently confirm the experimental environment for maintaining safety in the risk assessment regarding the laboratory, experimental equipment, and protective equipment in which chemical reactions are performed.

In this embodiment, an example is shown for middle item 1-4 "Hazard assessment of chemical substances" of major item 1 "Preparation of risk assessment plan" shown in FIG.

Hazardousness is the effect of chemical substances on human health and the environment, and risk assessment can be performed using the same method as the physical and chemical hazard assessment of chemical substances described in Examples 3 and 4. It is possible. Here, chemical substances used as raw materials and chemical substances used as reaction products are collectively evaluated for toxicity.

FIG. 43 is a diagram showing an example of a screen regarding hazardous evaluation of chemical substances. On the input screen 4301, a temporary save button 4302 and a register button 4303 can be used to temporarily save or register the input content. The input contents are registered or temporarily stored in the experiment protocol database 121 .

When the user clicks the data read button 4304, the management server 102 can display information such as the CAS number, manufacturer information, and presence/absence of SDS in the area 4310 for the chemical substance acquired on the input screen 1601 described above. . If there is an SDS for a chemical substance that is the target of hazard evaluation, the management server 102 extracts information on toxicity to the human body from area 2604 of the SDS and information on toxicity to the environment from area 2701 of the SDS. The contents can be displayed at 4313 and 4314 . Without SDS, management server 102 can use the information entered by the user on screens 1820 and 1830 .

The management server 102, in the same way as in the risk assessment of chemical substances, uses an arbitrary hazard designation list with regard to the content of hazards to health and the environment (4313, 4314) to determine the hazards of the chemical substances. They can be specified and displayed in areas 4315 and 4316 respectively. As an example of the hazard designation list, it is possible to use the same format as the chemical substance hazard designation list (FIG. 29) used in the chemical substance risk assessment. Other formats are possible.

Next, the management server 102 comprehensively evaluates whether or not the chemical substance can be used based on the hazard designation of the chemical substance using arbitrary evaluation criteria, and displays the result in an area 4320. do. If it is determined that the evaluation is canceled due to lack of information (level 4), for example, the user obtains the data or information necessary for the evaluation of the chemical substance for which the information is insufficient through an experiment or the like. The user can add the data or information obtained in this way and carry out the risk assessment again. As an example of arbitrary evaluation criteria, it is possible to use the same format as the risk evaluation criteria (FIG. 30) used in chemical substance risk assessment. Other formats are possible.

In the hazard assessment results of chemical substances, the management server 102 creates a model for recommendation using an arbitrary algorithm or method, and adds new data and information (associated information) associated with the chemical substance to the recommendation model. (4321). Also, the user's findings can be displayed in area 4330 .

If the chemical substance management system 134 that can be connected to the risk assessment support system 101 has an equivalent evaluation function, the hazard evaluation of the chemical substance can be substituted by that function.

As the information processing flow for evaluating the hazards of chemical substances, it is possible to use the flow of FIG. 31 used for evaluating the physical and chemical hazards of the substance. At this time, the "physical and chemical danger" of 3102 and the "danger" of 3103 are respectively read as "harmfulness". "Risk assessment" in 3104 should be read as "Hazard assessment".

According to the present embodiment, it is possible to efficiently collect and utilize information on the toxicity of chemical substances when performing risk assessment on the toxicity of chemical substances, and to perform high-quality risk assessment.

In this embodiment, major item 1 "Creation of risk assessment proposal" shown in FIG. An example will be described with reference to FIGS. 44 and 45. FIG.

When the user clicks the data read button 4404 on the input screen 4401 of FIG. 44, the management server 102 can display the acquisition status of the information on the chemical substance acquired on the input screen 1601 in the area 4405. If an SDS exists for a chemical substance subject to risk assessment, the management server 102 can extract information on laws and regulations to which the chemical substance applies from the SDS area 2702 and display it in area 4406. is.

Since the management server 102 acquires laws and regulations, it is possible to refer to not only domestic laws of Japan but also laws and regulations concerning chemical substance management in any country and international standards. It is also possible to refer to company rules and the like in the company rules and standards database 130 . In addition, the input screen 4401 can display the user's observations in an area 4407 regarding the legal regulations of the chemical substance. Furthermore, the management server 102 creates a recommendation model for laws and regulations to which the chemical substance applies, using any algorithm or method, and adds new data and information (accompanying information) associated with the chemical substance. ) can be displayed as a recommendation. As an example of recommendations, area 4408 shows information on how to dispose of chemical substances and information on overseas laws and regulations to be noted when using them in products and manufacturing processes.

In this way, in risk assessment, it is possible to conduct experiments with higher safety by confirming information on laws and regulations to which chemical substances apply.

A screen 4501 shown in FIG. 45 is a screen for outputting a risk assessment proposal regarding chemical reactions using chemical substances, described in the first to eighth embodiments. This screen is displayed when the user clicks the data read button 4504 . Information such as the affiliation, name, and user ID number of the creator (user) of the risk assessment plan is displayed in area 4502 . Area 4503 displays summary information about the experiment for risk assessment. Of these, an area 4505 can display information such as the name of the experiment theme, the acceptance number of the risk assessment proposal, the research theme linked to the experiment theme, and the research number. An area 4506 displays chemical substances and chemical reactions that are subject to risk assessment, and an area 4507 can display information on the laboratory and experimental equipment used.

Area 4510 can display the risk assessments shown in Examples 1 to 8 above for each item. Also, when the user clicks a detail button 4511 in each evaluation item, it is possible to transition from the area 4510 to another screen and display the details of the designated evaluation content.

The user can refer to the screen 4501 to grasp the outline of the evaluation plan. When the evaluation proposal is completed, the user can click button 4521 to submit the evaluation proposal for review. When interrupting the preparation of the evaluation plan, the user can use the button 4520 to temporarily save the contents of the evaluation plan in the experiment protocol database 121 . After the user initiates the proposal submission, the user can use button 4522 to pull back the proposal.

FIG. 46 is an information processing flow chart for confirmation of laws and regulations to which chemical substances apply and output of evaluation proposals. When the user clicks the data read button 4404 on the input screen 4401 of FIG. , is displayed in area 4405 (4601).

Next, the management server 102 extracts information such as laws and regulations applicable to the chemical substance from the relevant portion 2702 of the SDS and displays it in the area 4406 (4602). Subsequently, the management server 102 acquires accompanying information regarding the legal regulations of the chemical substance and displays it in the area 4408 (4606). Furthermore, the management server 102 acquires the user's opinion on legal regulations of the chemical substance and displays it in the area 4407 (4603). Finally, the management server 102 displays an output confirmation screen for the risk assessment plan exemplified in the screen 4501 (4604), and when the user clicks the application start button 4521, the assessment plan is output and the application for the risk assessment plan is submitted. Start (4604).

This embodiment enables the effective use of data and information associated with research and development on chemical substances when assessing risks related to chemical reactions using chemical substances, and aims to improve the efficiency of research and development on chemical substances and chemical reactions. can be done.

In this embodiment, an example of major item 2 "Deliberation and approval of risk assessment plan" shown in FIG. 2 will be described with reference to FIGS. 47, 48A, 48B and 48C. The risk assessment proposal is evaluated by multiple persons in charge, including the user.

FIG. 47 shows an input screen 4701 for an evaluator and an evaluation implementation date and time for the evaluation plan created in Example 8. In FIG. The input screen 4701 is generated by the management server 102 . When interrupting the data input, the user can use the button 4702 to temporarily save the input contents in the experiment protocol database 121 . When the user clicks the data read button 4704 , the management server 102 reads the evaluation proposal from the main memory 105 or the experiment protocol database 121 and displays information regarding the risk evaluation proposal, such as the creator and receipt number, in an area 4705 .

The user can then select and enter the affiliation and name of the evaluator of the proposed risk assessment in area 4710 . At this time, it is possible to carry out the risk assessment over multiple stages in accordance with the regulations of the research and development department to which the research and development department belongs. In this case, it is possible to input the evaluator at each stage. Area 4710 provides an example of a two-step risk assessment.

The management server 102 confirms the schedule of the user who created the risk assessment proposal and the evaluator specified in the area 4710 in a database (not shown) or a system having a schedule management function, and determines the date and time when the risk assessment can be performed. Candidates 4721 can be displayed in area 4720 . If there are multiple candidate dates and times, the user can specify an arbitrary date and time.

Area 4730 allows the user who created the proposed risk assessment to enter comments for the evaluator. When the user clicks the send button 4703 , the management server 102 can send a risk evaluation request e-mail to the evaluator and display a message to that effect in the area 4740 .

48A, 48B and 48C are user input screens for acceptance of risk assessment request, approval of assessment proposal, and database storage of assessed risk assessment content, respectively. These input screens are generated by the management server 102 . The evaluator who received the risk evaluation request can receive the evaluation request message shown on the screen 4801 shown in FIG. It is possible. A summary of the proposed evaluation is displayed in area 4802 . When the evaluator confirms the details of the contents of the risk assessment proposal, the evaluator can display the evaluation proposal with a button 4803 .

Candidates for the execution date and time of risk assessment are displayed in area 4804 . The evaluator can confirm the content of the risk assessment proposal and enter comments regarding the content of the risk assessment in area 4805 . If the risk assessment is to be performed at the proposed date and time, the evaluator can click button 4806 to communicate this to the risk assessment proposal creator via management server 102 . If the proposed date and time are inconvenient, or if the content of the risk assessment proposal is insufficient and the evaluator wishes to request resubmission, the evaluator can press button 4807 to decline the risk assessment. The management server 102 receives a response of accepting or declining the risk assessment from the evaluator, and transmits it to the user terminal of the draft risk assessment creator.

After performing the risk assessment, the assessor can enter the assessment results on screen 4810 illustrated in FIG. 48B. If the evaluation result is approval, when the evaluator clicks the approval button 4813 , the management server 102 assigns an approval number to the risk assessment proposal and displays it in area 4814 . If the evaluation result is rejection or rejection, the evaluator clicks button 4812 . Furthermore, the evaluator can enter comments regarding the evaluation results in area 4811 . The management server 102 holds the evaluation results in the main memory 105 and/or the experimental plan database 121, and transmits them to the user terminal of the creator of the evaluation plan.

When risk evaluation is performed in multiple stages, the number of input screens 4801 and 4810 can be increased according to the number of evaluation stages.

If the evaluation is approved, the user who created the evaluation proposal can register the evaluation proposal in the protocol database 121 using an input screen 4820 illustrated in FIG. 48C. When the user clicks the data read button 4821 and the send button 4823, the management server 102 reads the approved risk assessment proposal from the main memory 105, and further transmits and registers it to the experiment protocol database 121. can. Draft assessment results may be registered with the approved draft risk assessment. The user can use the temporary save button 4822 to interrupt the registration work to the database. The management server 102 temporarily saves the data in the experiment protocol database 121 .

FIG. 49 is a diagram showing an information processing flow regarding acceptance of a risk evaluation request, approval of a risk evaluation proposal, and storage of the risk evaluation proposal in the database. In the input screen 4701 of FIG. 47, when the creator of the risk assessment draft clicks the data read button 4704, the management server 102 of the risk assessment support system 101 acquires the risk assessment draft (4901). Next, the management server 102 acquires the evaluator information entered in the area 4710 (4902), confirms the schedule of the risk assessment draft creator and the evaluator, and recommends candidates for the date and time and location of the risk assessment. , the information is displayed in area 4720 (4903). The management server 102 receives the date and place information specified by the draft creator (4904).

Next, the management server 102 transmits an evaluation request to the evaluator (4905). When the management server 102 receives a response of acceptance of the risk assessment from the evaluator (the user terminal of the user), it determines the date and place of implementation of the risk assessment (4906). Send to

The management server 102 acquires the determined results of the risk assessment (4907), and stores the content of the risk assessment in the protocol database 121 (4908). After that, the management server 102 can add information obtained by actually conducting the experiment to the risk evaluation contents stored in the experiment protocol database 121 (4909).

This embodiment enables the effective use of data and information associated with research and development on chemical substances when assessing risks related to chemical reactions using chemical substances, and aims to improve the efficiency of research and development on chemical substances and chemical reactions. can be done.

In addition, the present invention is not limited to the above-described embodiments, and includes various modifications. For example, the above-described embodiments have been described in detail in order to explain the present invention in an easy-to-understand manner, and are not necessarily limited to those having all the described configurations. In addition, it is possible to replace part of the configuration of one embodiment with the configuration of another embodiment, and it is also possible to add the configuration of another embodiment to the configuration of one embodiment. Moreover, it is possible to add, delete, or replace a part of the configuration of each embodiment with another configuration.

Further, each of the configurations, functions, processing units, etc. described above may be realized by hardware, for example, by designing a part or all of them using an integrated circuit. Moreover, each of the above configurations, functions, etc. may be realized by software by a processor interpreting and executing a program for realizing each function. Information such as programs, tables, and files that implement each function can be stored in recording devices such as memories, hard disks, SSDs (Solid State Drives), or recording media such as IC cards and SD cards.

The storage device on which the above hardware or software is installed can be divided into a plurality of hardware or storage devices according to the above configurations, functions, and processing contents. In addition, multiple hardware or software storage devices resulting from partitioning do not have to be installed in the same location, and some of the partitioned hardware or storage devices can be used through an Internet connection. It is possible to Furthermore, a storage device equipped with the above-mentioned hardware or software used through Internet connection can be provided as a paid or free service by a company different from the company to which the organization conducting the risk assessment belongs. .

In addition, the control lines and information lines indicate those considered necessary for explanation, and not all control lines and information lines are necessarily indicated on the product. In fact, it may be considered that almost all configurations are interconnected.

101 Risk assessment support system 102 Management server 106 Search history database 112 SDS database of other company's products 116 Domestic laws and regulations database 118 Internet connection 120 SDS database of in-house product 121 Experiment protocol database 131 Client Terminal 132 Reagent Management System 133 Ordering System 134 Chemical Substance Management System 501 Portal Screen 4501 Confirmation and Output Screen of Risk Assessment Draft

Claims (14)

one or more databases storing multiple types of data and information related to research and development;
a management system that accesses the one or more databases to process information,
The one or more databases are information on current and past research and development, and contain research and development-related information including usage information of chemical substances in the current and past research and development, and chemical substance-related information on chemical substances. store and
The management system includes:
Receiving input of information indicating one or more chemical substances,
generating and outputting information that supports risk assessment regarding the one or more chemical substances and chemical reactions of the one or more chemical substances based on the chemical substance-related information and the research and development related information ;
searching the one or more databases for research and development information associated with the input user identification information;
extracting information including a research theme of the designated research and development from the information on research and development associated with the user identification information, and including it in the information supporting the risk assessment;
searching the one or more databases for information about chemical substances corresponding to the information indicating the input chemical substance;
including information about the corresponding chemical substance found in the chemical substance-related information in the information supporting the risk assessment;
A chemical substance and chemical reaction risk assessment support system that includes input information on equipment extracted from the research and development related information in the information that assists the risk assessment. The chemical substance and chemical reaction risk assessment support system according to claim 1,
The management system receives user input of information on the corresponding chemical substance and includes information on the corresponding chemical substance in the information supporting the risk assessment when the information on the corresponding chemical substance is not found in the chemical substance-related information. Reaction risk assessment support system. The chemical substance and chemical reaction risk assessment support system according to claim 1 or 2,
the information about the corresponding chemical includes information about the properties of the corresponding chemical;
The management system includes the risk and/or toxicity determination result of the input chemical substance in the information supporting the risk assessment, based on preset evaluation criteria. Chemical substance and chemical reaction risk Evaluation support system. The chemical substance and chemical reaction risk assessment support system according to claim 3,
The hazards and/or hazards of the input chemical substance are the hazards based on the physicochemical properties of the input chemical substance, the hazards of the input chemical substance to human health, the A chemical substance and chemical reaction risk assessment support system including at least one of: hazard of the input chemical substance to the environment. The chemical substance and chemical reaction risk assessment support system according to claim 4,
The management system extracts information associated with the characteristics of the input chemical substance from the one or more databases according to a preset recommendation model, and includes it in the information supporting the risk assessment. Chemical reaction risk assessment support system. The chemical substance and chemical reaction risk assessment support system according to claim 1 or 2,
the information about the properties of the corresponding chemical includes information about chemical reactions involving the corresponding chemical;
The management system determines the risk of a chemical reaction involving the corresponding chemical substance based on preset evaluation criteria, and includes it in the information supporting the risk assessment, chemical substance and chemical reaction risk assessment. support system. The chemical substance and chemical reaction risk assessment support system according to claim 6,
The management system extracts information associated with chemical reactions involving the corresponding chemical substance from the one or more databases according to a preset recommendation model, and includes the information supporting the risk assessment. Substance and chemical reaction risk assessment support system. The chemical substance and chemical reaction risk assessment support system according to claim 1 or 2,
The information on the corresponding chemical substance includes information on laws and regulations to which the corresponding chemical substance is subject,
A chemical substance and chemical reaction risk assessment support system, wherein the management system includes the information on the laws and regulations in the information supporting the risk assessment. The chemical substance and chemical reaction risk assessment support system according to claim 1 or 2,
The information about the equipment includes information about specifications of a laboratory and/or experimental equipment that handles the corresponding chemical substance, and a chemical substance and chemical reaction risk evaluation support system. The chemical substance and chemical reaction risk assessment support system according to claim 9,
The management system extracts information associated with the use of the equipment from the one or more databases according to a preset recommendation model, and includes it in the information supporting the risk assessment, chemical substance and chemical reaction risk assessment support. system. The chemical substance and chemical reaction risk assessment support system according to any one of claims 1 to 10,
Based on the information supporting the risk assessment, the management system includes the results of risk assessments performed by a plurality of persons in charge including the user indicated by the user identification information in the information supporting the risk assessment. Chemical reaction risk assessment support system. The chemical substance and chemical reaction risk assessment support system according to any one of claims 1 to 10,
The management system acquires information on the inventory of the corresponding chemical substance from other information systems connected to the chemical substance and chemical reaction risk assessment support system and includes it in the information supporting the risk assessment. Substance and chemical reaction risk assessment support system. The chemical substance and chemical reaction risk assessment support system according to any one of claims 1 to 10,
The chemical substance and chemical reaction risk assessment support system, wherein the management system includes information obtained by conducting a chemical reaction involving the corresponding chemical substance in the research and development related information. A method for supporting risk assessment by a management system that accesses and processes one or more databases storing multiple types of data and information related to research and development, comprising:
The one or more databases are information on current and past research and development, and contain research and development-related information including usage information of chemical substances in the current and past research and development, and chemical substance-related information on chemical substances. store and
The method includes:
the management system receives input of information indicative of one or more chemical substances;
The management system generates and outputs information that supports risk assessment regarding the one or more chemical substances and chemical reactions of the one or more chemical substances based on the chemical substance-related information and the research and development related information,
the management system searches the one or more databases for information about research and development associated with the input user identification information;
The management system extracts information including a research theme of the designated research and development from the information on research and development associated with the user identification information, and includes it in the information supporting the risk assessment,
The management system searches the one or more databases for information about chemical substances corresponding to the input information indicating the chemical substance,
the management system including information about the corresponding chemical found in the chemical-related information in information supporting the risk assessment;
A method, wherein the management system includes the input information about equipment extracted from the research and development related information in the information supporting the risk assessment.

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