JP7144028B2 - Cleaning and sanitizing agent composition - Google Patents
Cleaning and sanitizing agent composition Download PDFInfo
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- JP7144028B2 JP7144028B2 JP2018100620A JP2018100620A JP7144028B2 JP 7144028 B2 JP7144028 B2 JP 7144028B2 JP 2018100620 A JP2018100620 A JP 2018100620A JP 2018100620 A JP2018100620 A JP 2018100620A JP 7144028 B2 JP7144028 B2 JP 7144028B2
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- alkyl ether
- polyoxyethyleneoxypropylene
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- 239000000203 mixture Substances 0.000 title claims description 45
- 238000004140 cleaning Methods 0.000 title claims description 35
- 238000011012 sanitization Methods 0.000 title claims description 9
- 239000002280 amphoteric surfactant Substances 0.000 claims description 25
- -1 polyoxyethyleneoxypropylene Polymers 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 18
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 17
- 150000005215 alkyl ethers Chemical class 0.000 claims description 15
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 12
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 12
- 229960003237 betaine Drugs 0.000 claims description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 10
- 239000000194 fatty acid Substances 0.000 claims description 10
- 229930195729 fatty acid Natural products 0.000 claims description 10
- 150000004665 fatty acids Chemical class 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 229940078672 didecyldimethylammonium Drugs 0.000 claims description 8
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 7
- JGFDZZLUDWMUQH-UHFFFAOYSA-N Didecyldimethylammonium Chemical group CCCCCCCCCC[N+](C)(C)CCCCCCCCCC JGFDZZLUDWMUQH-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 229920002413 Polyhexanide Polymers 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- PDIZYYQQWUOPPK-UHFFFAOYSA-N acetic acid;2-(methylamino)acetic acid Chemical compound CC(O)=O.CC(O)=O.CNCC(O)=O PDIZYYQQWUOPPK-UHFFFAOYSA-N 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 description 20
- 239000012459 cleaning agent Substances 0.000 description 16
- 230000001954 sterilising effect Effects 0.000 description 12
- 125000004432 carbon atom Chemical group C* 0.000 description 11
- 229920006395 saturated elastomer Polymers 0.000 description 11
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 125000000217 alkyl group Chemical group 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 230000000249 desinfective effect Effects 0.000 description 8
- 239000002736 nonionic surfactant Substances 0.000 description 8
- 235000013305 food Nutrition 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 235000019864 coconut oil Nutrition 0.000 description 4
- 239000003240 coconut oil Substances 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 125000005210 alkyl ammonium group Chemical group 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000003093 cationic surfactant Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 150000007522 mineralic acids Chemical class 0.000 description 3
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- ZOGQZENZBUCGPX-UHFFFAOYSA-N 3-(dodecanoylamino)propyl 2-(dimethylamino)acetate Chemical compound C(CCCCCCCCCCC)(=O)NCCCOC(CN(C)C)=O ZOGQZENZBUCGPX-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000228153 Penicillium citrinum Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- MVTVVKOMNZGDGD-UHFFFAOYSA-M didecyl(dimethyl)azanium;hydron;carbonate Chemical compound OC([O-])=O.CCCCCCCCCC[N+](C)(C)CCCCCCCCCC MVTVVKOMNZGDGD-UHFFFAOYSA-M 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 235000019795 sodium metasilicate Nutrition 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- HWCHICTXVOMIIF-UHFFFAOYSA-M sodium;3-(dodecylamino)propanoate Chemical compound [Na+].CCCCCCCCCCCCNCCC([O-])=O HWCHICTXVOMIIF-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
本発明は、主に病院や工場等の器具、設備および作業者の手指等の洗浄除菌に用いる洗浄除菌剤組成物に関する。 TECHNICAL FIELD The present invention relates to a cleaning/disinfecting agent composition mainly used for cleaning/disinfecting equipment, facilities, and workers' fingers in hospitals and factories.
病院、食品工場などでは器具、設備および作業者の手指等を洗浄し、除菌する必要があり、従来からアルキルジメチルベンジルアンモニウムクロリド、アルキルトリメチルアンモニウムブロミド等の除菌力を有する陽イオン界面活性剤を含有する水溶液からなる除菌剤組成物が用いられている。 In hospitals, food factories, etc., it is necessary to wash and disinfect equipment, equipment, and workers' fingers, etc., and cationic surfactants with disinfecting power such as alkyldimethylbenzylammonium chloride and alkyltrimethylammonium bromide have been used conventionally. A disinfectant composition consisting of an aqueous solution containing is used.
しかし、陽イオン界面活性剤を含有する水溶液からなる除菌剤組成物は除菌力はあるものの十分な洗浄力を持たないものであり、洗浄力を高めるために通常の洗浄剤、例えば陰イオン界面活性剤を併用すると、その除菌効力が著しく低下することが知られている。そのため病院、食品工場などでは洗浄と除菌は２つの工程に分けて行わねばならないという問題があった。 However, disinfectant compositions composed of aqueous solutions containing cationic surfactants have disinfecting power but do not have sufficient detergency. It is known that when a surfactant is used in combination, its sterilizing effect is significantly reduced. Therefore, in hospitals, food factories, etc., there is a problem that cleaning and sterilization must be performed in two steps.
このような問題点を解決するために特許文献１においては、陽イオン界面活性剤としてジ長鎖アルキルジ短鎖アルキルアンモニウム塩と、両性界面活性剤とを含有する水溶液を用いることによって洗浄と除菌が一つの工程で行える殺菌洗浄剤組成物が提案されている。 In order to solve such problems, Patent Document 1 discloses cleaning and sterilization by using an aqueous solution containing a di-long-chain alkyl di-short-chain alkylammonium salt as a cationic surfactant and an amphoteric surfactant. is proposed in one step.
ところが、特許文献１に記載されるような殺菌洗浄剤組成物においては、ジ長鎖アルキルジ短鎖アルキルアンモニウム塩に対する両性界面活性剤の量比を、組成物に安定性を与えるために１：１．２５～２．５０モルとする必要があり、高価な両性界面活性剤な多量に用いなければならず、コスト面で問題があった。即ち、コスト削減のためにジ長鎖アルキルジ短鎖アルキルアンモニウム塩に対する両性界面活性剤の量比を１：１．２５未満とすると、白濁や分離を生じ、組成物の安定性が低下する傾向があった。 However, in the disinfecting detergent composition as described in Patent Document 1, the amount ratio of the amphoteric surfactant to the dilong-chain alkyldishort-chain alkylammonium salt is set to 1:1 in order to impart stability to the composition. 0.25 to 2.50 mol, and a large amount of the expensive amphoteric surfactant must be used, resulting in a cost problem. That is, if the ratio of the amphoteric surfactant to the di-long-chain alkyl di-short-chain alkylammonium salt is set to less than 1:1.25 for cost reduction, turbidity and separation will occur, and the stability of the composition tends to decrease. there were.
また、特許文献１の殺菌洗浄剤組成物においては、さらに非イオン界面活性剤を含有させることが記載されているが、非イオン界面活性剤の種類や混合割合によっては、安定性や洗浄力が低下することがあった。 Further, in the sterilizing detergent composition of Patent Document 1, it is described that a nonionic surfactant is further contained, but depending on the type and mixing ratio of the nonionic surfactant, stability and detergency may be reduced. sometimes decreased.
特許文献２には、ジデシルジメチルアンモニウムクロライド、両性界面活性剤、ポリオキシエチレンオキシプロピレンアルキルエーテルおよびエタノールを特定の割合で含有する洗浄除菌剤組成物が記載されている。しかしながら、ジデシルジメチルアンモニウムクロライドはカビなどの真菌類に対する除菌効果が不十分であるうえ、使用後にぬめりが残り易く、すすぎに手間が掛かる場合もあった。 Patent Document 2 describes a cleaning and disinfecting agent composition containing didecyldimethylammonium chloride, amphoteric surfactant, polyoxyethyleneoxypropylene alkyl ether and ethanol in specific proportions. However, didecyldimethylammonium chloride has an insufficient bactericidal effect against fungi such as mold, and it tends to leave a slimy residue after use.
上記のような背景から、洗浄力に優れ、カビなどの真菌類に対しても優れた除菌効果を有し、薬剤が残留しにくい洗浄除菌剤組成物が望まれていた。 In view of the above background, there has been a demand for a cleaning/disinfectant composition that has excellent detergency, has an excellent sterilizing effect against fungi such as mold, and does not easily leave chemicals behind.
本発明の目的は、高い洗浄力および除菌力を維持しつつ、安定性に優れ、薬剤が残留しにくい洗浄除菌剤組成物を提供することにある。 SUMMARY OF THE INVENTION An object of the present invention is to provide a cleaning and disinfecting agent composition that maintains high detergency and sterilization power, is excellent in stability, and is less likely to leave residual chemicals.
本発明者らは、鋭意検討の結果、特定の四級アンモニウム塩、両性界面活性剤、非イオン界面活性剤およびエタノールを特定の量比で含有する組成物が上記課題を解決することを見出し本発明を完成させるに至った。 As a result of intensive studies, the present inventors have found that a composition containing a specific quaternary ammonium salt, an amphoteric surfactant, a nonionic surfactant and ethanol in a specific ratio can solve the above problems. I have completed my invention.
すなわち本発明は、下記一般式（１）で示される第四級アンモニウム塩、両性界面活性剤およびポリオキシエチレンオキシプロピレンアルキルエーテルを含有し、第四級アンモニウム塩とポリオキシエチレンオキシプロピレンアルキルエーテルの重量比が１：０．３～１：０．９であり、１重量％水溶液のｐＨが３．８～６．５である洗浄除菌剤組成物（但しヨウ素分子は含まない）に関する。
本発明で用いられる第四級アンモニウム塩は、下記一般式（１）で示されるものである。
Ｒ１、Ｒ２で表されるアルキル基は炭素数８～１８のアルキル基、例えば２－エチルヘキシル、オクチル、デシル、ドデシル、オクチル、ステアリル等であるが、特に好ましくは炭素数８～１０のアルキル基である。Ｒ１とＲ２は、同一であっても異なっていてもよい。 The alkyl group represented by R 1 and R 2 is an alkyl group having 8 to 18 carbon atoms, such as 2-ethylhexyl, octyl, decyl, dodecyl, octyl, stearyl, etc., but alkyl groups having 8 to 10 carbon atoms are particularly preferred. is the base. R 1 and R 2 may be the same or different.
Ｒ３は炭素数１～４の飽和または不飽和のアルキル基またはポリオキシアルキル基である。ポリオキシアルキル基である場合は、繰り返し単位が１～２０、好ましくは、繰り返し単位が１～２である。Ｒ３は、メチル基、エチル基、ポリオキシメチル基、ポリオキシエチル基が好ましく、メチル基またはポリオキシメチル基がより好ましく、ポリオキシメチル基がさらに好ましい。 R 3 is a saturated or unsaturated alkyl group or polyoxyalkyl group having 1 to 4 carbon atoms. When it is a polyoxyalkyl group, it has 1 to 20 repeating units, preferably 1 to 2 repeating units. R 3 is preferably a methyl group, an ethyl group, a polyoxymethyl group or a polyoxyethyl group, more preferably a methyl group or a polyoxymethyl group, even more preferably a polyoxymethyl group.
Ｒ４は、炭素数１～４の飽和または不飽和のアルキル基であり、メチル基またはエチル基が好ましく、メチル基がより好ましい。 R 4 is a saturated or unsaturated alkyl group having 1 to 4 carbon atoms, preferably a methyl group or an ethyl group, more preferably a methyl group.
本発明において、第四級アンモニウム塩は、長鎖アルキル基を１分子中に２個有している必要がある。長鎖アルキル基を１個有する、例えば、従来から除菌剤として知られているアルキルトリメチルアンモニウムブロミド等ではこれを両性界面活性剤と併用したときに十分な洗浄除菌力を発現し得ない。長鎖アルキル基の炭素数が８より小さくても１８より大きくても十分な除菌力を発現しない。両性界面活性剤と併用したとき特に高い除菌効力を発現し、かつ洗浄力が低下しないアルキル基は２－エチルヘキシル、オクチルまたはデシルである。 In the present invention, the quaternary ammonium salt must have two long-chain alkyl groups per molecule. For example, alkyltrimethylammonium bromide, which has one long-chain alkyl group and is conventionally known as a disinfectant, cannot exhibit sufficient cleaning and disinfecting power when used in combination with an amphoteric surfactant. Even if the number of carbon atoms in the long-chain alkyl group is less than 8 or more than 18, sufficient sterilizing power is not exhibited. Alkyl groups that exhibit particularly high sterilization efficacy and do not reduce detergency when used in combination with an amphoteric surfactant are 2-ethylhexyl, octyl and decyl.
対イオンであるアニオンとしては、無機酸対イオン（ＨＳＯ４ －，ＮＯ３ －，Ｈ２ＰＯ４ －など）または有機酸対イオン（Ｃ２Ｈ５ＣＯ２ －，ＣＨ３ＯＳＯ３ －，Ｃ２Ｈ５ＳＯ３ －，ＣＨ３ＣＯ２ －，ＣＨ３Ｃ６Ｈ４ＳＯ３ －，ＣＨ３ＳＯ３ －など）が挙げられる。 Examples of anions which are counter ions include inorganic acid counter ions (HSO 4 − , NO 3 − , H 2 PO 4 − etc.) or organic acid counter ions (C 2 H 5 CO 2 − , CH 3 OSO 3 − , C 2 H5SO3- , CH3CO2- , CH3C6H4SO3- , CH3SO3- , etc. ) . _ _ _
一般式（１）で示される第四級アンモニウム塩の具体例としては、ジデシルメチルポリオキシエチルアンモニウムプロピオン酸塩およびジデシルジメチルアンモニウムメチル硫酸塩、ジデシルジメチルアンモニウム重炭酸塩などが挙げられる。これらの中でジデシルメチルポリオキシエチルアンモニウムプロピオン酸塩、ジデシルジメチルアンモニウムメチル硫酸塩が好ましく、ジデシルメチルポリオキシエチルアンモニウムプロピオン酸塩がより好ましい。 Specific examples of the quaternary ammonium salts represented by formula (1) include didecylmethylpolyoxyethylammonium propionate, didecyldimethylammonium methylsulfate, and didecyldimethylammonium bicarbonate. Among these, didecylmethylpolyoxyethylammonium propionate and didecyldimethylammonium methylsulfate are preferred, and didecylmethylpolyoxyethylammonium propionate is more preferred.
両性界面活性剤としては、例えば、ベタイン型両性界面活性剤；特に以下のようなものが挙げられる。 Amphoteric surfactants include, for example, betaine-type amphoteric surfactants;
一般式（２）；
で示されるアルキルアミドベタイン型両性界面活性剤（例えばヤシ油脂肪酸アミドプロピルジメチルアミノ酢酸ベタイン、ラウリン酸アミドプロピルジメチルアミノ酢酸ベタイン）；
general formula (2);
Alkylamidobetaine amphoteric surfactants represented by (e.g. coconut fatty acid amidopropyldimethylaminoacetate betaine, lauramidopropyldimethylaminoacetate betaine);
一般式（３）；
で示されるアルキルベタイン型両性界面活性剤（例えばヤシ油アルキルジメチルアミノ酢酸ベタイン、ラウリルジメチルアミノ酢酸ベタイン）；
general formula (3);
Alkylbetaine-type amphoteric surfactants represented by (e.g., betaine coconut oil alkyldimethylaminoacetate, betaine lauryldimethylaminoacetate);
一般式（４）；
で示されるイミダゾリニウムベタイン型両性界面活性剤（例えば２－ヤシ油アルキル－１－カルボキシエチル－１－ヒドロキシエチルイミダゾリニウムベタイン液）。
general formula (4);
imidazolinium betaine type amphoteric surfactant represented by (for example, 2-coconut alkyl-1-carboxyethyl-1-hydroxyethyl imidazolinium betaine solution).
両性界面活性剤としてはさらに、アミノ酸型両性界面活性剤（例えばラウリルアミノプロピオン酸ナトリウム）が挙げられる。 Amphoteric surfactants further include amino acid-type amphoteric surfactants (eg, sodium laurylaminopropionate).
これらのうちで好ましいものはアルキルアミドベタイン型両性界面活性剤及びアルキルベタイン型両性界面活性剤であるが、特にアルキルアミドベタイン型両性界面活性剤が好ましく、その中でもヤシ油脂肪酸アミドプロピルベタインが好ましい。 Of these, alkylamidobetaine type amphoteric surfactants and alkylbetaine type amphoteric surfactants are preferred, but alkylamidobetaine type amphoteric surfactants are particularly preferred, and coconut oil fatty acid amidopropyl betaine is particularly preferred.
両性界面活性剤の割合としては、一般式（１）で示される第四級アンモニウム塩１重量部に対して、０．０１～１．２重量部であるのが好ましく、０．０５～１重量部であるのがより好ましく、０．１～０．５重量部であるのがさらに好ましい。 The ratio of the amphoteric surfactant is preferably 0.01 to 1.2 parts by weight, preferably 0.05 to 1 part by weight, per 1 part by weight of the quaternary ammonium salt represented by the general formula (1). parts by weight, more preferably 0.1 to 0.5 parts by weight.
本発明の洗浄除菌剤組成物においては、さらに非イオン界面活性剤として、ポリオキシエチレンオキシプロピレンアルキルエーテルを含有させることが重要である。洗浄除菌剤の分野で用いられる非イオン界面活性剤としては、ポリオキシエチレンオキシプロピレンアルキルエーテル以外に、ポリオキシエチレンポリオキシプロピレンブロックポリマー、脂肪酸アルカノールアミド、ポリオキシエチレン脂肪酸エステル、ポリプロピレングリコール等も知られているが、これらの非イオン界面活性剤を本発明で用いるポリオキシエチレンオキシプロピレンアルキルエーテルに代えて使用すると混合時に分離したり、一旦混合されても低温状態では分離が起こるなど、安定性に問題があるため、本発明の洗浄除菌剤組成物に用いることはできない。 It is important that the cleaning and disinfecting agent composition of the present invention further contains polyoxyethyleneoxypropylene alkyl ether as a nonionic surfactant. In addition to polyoxyethyleneoxypropylene alkyl ethers, nonionic surfactants used in the field of cleaning and sanitizing agents include polyoxyethylene polyoxypropylene block polymers, fatty acid alkanolamides, polyoxyethylene fatty acid esters, polypropylene glycol, and the like. Although it is known, when these nonionic surfactants are used in place of the polyoxyethyleneoxypropylene alkyl ether used in the present invention, they separate during mixing, and even if they are mixed, separation occurs at low temperatures. It cannot be used in the cleaning and sanitizing composition of the present invention because of its properties.
ポリオキシエチレンオキシプロピレンアルキルエーテルは、一般式（１）で示される第四級アンモニウム塩に対する重量比が、１：０．３～１：０．９となるように配合すればよく、１：０．３３～１：０．８５が好ましく、１：０．３５～１：０．８がより好ましい。 The polyoxyethyleneoxypropylene alkyl ether may be blended so that the weight ratio to the quaternary ammonium salt represented by the general formula (1) is 1:0.3 to 1:0.9. 0.33 to 1:0.85 is preferred, and 1:0.35 to 1:0.8 is more preferred.
本発明の洗浄除菌剤組成物において用いるポリオキシエチレンオキシプロピレンアルキルエーテルは、ＨＬＢ値が８～１６のものが好ましく、１０～１６のものがより好ましく、１１～１５のものがさらに好ましい。 The polyoxyethyleneoxypropylene alkyl ether used in the cleaning and disinfecting agent composition of the present invention preferably has an HLB value of 8-16, more preferably 10-16, and even more preferably 11-15.
また、本発明の洗浄除菌剤組成物は、上記成分を適宜混合することにより調製されるが、洗浄除菌効果を十分に発揮させるために、組成物のｐＨも重要となる。したがって、本発明の洗浄除菌剤組成物は、１重量％水溶液を調製した際のｐＨが３．８～６．５、好ましくは３．９～６．４、より好ましくは４～６．３となるように調製する必要がある。ｐＨは、本発明の洗浄除菌剤組成物の洗浄除菌効果を妨げない範囲であれば、水酸化ナトリウム、水酸化カリウム、クエン酸、リン酸塩、ケイ酸塩、無水マレイン酸、炭酸ナトリウム等の公知のｐＨ調整剤を用いて調整してもよい。ｐＨが３．８未満である場合、洗浄除菌対象の金属部分に腐食が生じやすく、ｐＨが６．５を超える場合、殺菌力が低下する傾向がある。 The cleaning and disinfecting agent composition of the present invention is prepared by appropriately mixing the above components, and the pH of the composition is also important in order to sufficiently exhibit the cleaning and disinfecting effect. Therefore, the cleaning and disinfecting agent composition of the present invention has a pH of 3.8 to 6.5, preferably 3.9 to 6.4, more preferably 4 to 6.3 when a 1% by weight aqueous solution is prepared. should be prepared so that Sodium hydroxide, potassium hydroxide, citric acid, phosphate, silicate, maleic anhydride, and sodium carbonate are used as long as the pH is within a range that does not interfere with the cleaning and disinfecting effect of the cleaning and disinfecting agent composition of the present invention. You may adjust using well-known pH adjusters, such as. If the pH is less than 3.8, metal parts to be cleaned and sterilized tend to be corroded, and if the pH exceeds 6.5, the sterilizing power tends to decrease.
本発明の洗浄除菌剤組成物は上記成分に加え、洗浄除菌効果を妨げない範囲で、さらにエタノール、イソプロピルアルコール、エチレングリコール、プロピレングリコール、ポリエチレングリコール、ポリヘキサメチレンビグアナイド塩酸塩等の副成分を含有してもよい。例えば、より広い抗菌スペクトルを有する組成物とする目的で、ポリヘキサメチレンビグアナイド塩酸塩を含有させてもよいし、保管安定性や溶状改善を目的にエタノールやエチレングリコールを含有させてもよい。これら副成分は、目的に応じて２種以上を含有してもよい。これら副成分の割合は、一般式（１）で示される第四級アンモニウム塩１重量部に対して、０．０１～１重量部が好ましく、０．０３～０．７重量部がより好ましく、０．０５～０．５重量部がさらに好ましい。 In addition to the above components, the cleaning and disinfecting agent composition of the present invention further contains subcomponents such as ethanol, isopropyl alcohol, ethylene glycol, propylene glycol, polyethylene glycol, and polyhexamethylene biguanide hydrochloride within a range that does not interfere with the cleaning and disinfecting effect. may contain. For example, polyhexamethylene biguanide hydrochloride may be included for the purpose of making a composition having a broader antibacterial spectrum, and ethanol or ethylene glycol may be included for the purpose of improving storage stability and solubility. These subcomponents may contain two or more kinds depending on the purpose. The proportion of these subcomponents is preferably 0.01 to 1 part by weight, more preferably 0.03 to 0.7 parts by weight, per 1 part by weight of the quaternary ammonium salt represented by the general formula (1). 0.05 to 0.5 parts by weight is more preferred.
その他、必要により含有させることのできる他の添加剤としては例えば、トリポリリン酸ナトリウム、メタケイ酸ナトリウム、炭酸ナトリウムなどのアルカリ性ビルダー、エチレンジアミンテトラアセテート（ＥＤＴＡ）、Ｎ－ヒドロキシエチル－エチレンジアミントリアセテート（ＨＥＤＴＡ）、トリエタノールアミンなどの有機金属イオン封鎖剤、着色料、香料が挙げられる。これら他の添加剤の割合は、通常、一般式（１）で示される第四級アンモニウム塩１重量部に対して、０．２５重量部以下である。 In addition, other additives that can be contained if necessary include alkaline builders such as sodium tripolyphosphate, sodium metasilicate and sodium carbonate, ethylenediaminetetraacetate (EDTA), N-hydroxyethyl-ethylenediaminetriacetate (HEDTA), Organic sequestering agents such as triethanolamine, coloring agents, and fragrances are included. The ratio of these other additives is usually 0.25 parts by weight or less per 1 part by weight of the quaternary ammonium salt represented by general formula (1).
本発明の具体的な洗浄除菌剤組成物として、例えば、ジデシルメチルポリオキシエチルアンモニウムプロピオン酸塩１重量部に対して、ヤシ油脂肪酸アミドプロピルジメチルアミノ酢酸ベタインを０．２～０．３重量部、ポリオキシエチレンオキシプロピレンアルキルエーテルを０．３～０．５重量部、エタノールを０～０．３重量部、およびエチレングリコールを０．１～０．２重量部含有する、洗浄除菌組成物が挙げられる。 As a specific cleaning and disinfecting agent composition of the present invention, for example, 0.2 to 0.3 of coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine is added to 1 part by weight of didecylmethylpolyoxyethylammonium propionate. parts by weight, 0.3 to 0.5 parts by weight of polyoxyethyleneoxypropylene alkyl ether, 0 to 0.3 parts by weight of ethanol, and 0.1 to 0.2 parts by weight of ethylene glycol. compositions.
また、別の具体的な洗浄除菌剤組成物として、例えば、ジデシルジメチルアンモニウムメチル硫酸塩１重量部に対して、ヤシ油脂肪酸アミドプロピルジメチルアミノ酢酸ベタインを０．１～０．３重量部、ポリオキシエチレンオキシプロピレンアルキルエーテルを０．６～０．８重量部、エタノールを０～０．２重量部、およびポリヘキサメチレンビグアナイド塩酸塩を０～０．２重量部含有する、洗浄除菌剤組成物が挙げられる。 Further, as another specific cleaning and disinfecting agent composition, for example, 0.1 to 0.3 parts by weight of betaine coconut oil fatty acid amidopropyldimethylaminoacetate is added to 1 part by weight of didecyldimethylammonium methylsulfate. , 0.6 to 0.8 parts by weight of polyoxyethyleneoxypropylene alkyl ether, 0 to 0.2 parts by weight of ethanol, and 0 to 0.2 parts by weight of polyhexamethylene biguanide hydrochloride. agent compositions.
本発明の洗浄除菌剤組成物は、一般式（１）で示される第四級アンモニウム塩が水溶液中１～４０重量％、好ましくは２～３０重量％、さらに好ましくは５～２０重量％となる濃度で提供する。かかる水溶液を希釈せずに使用することも可能であるが、通常は使用時に一般式（１）で示される第四級アンモニウム塩が５０～１００００ｐｐｍ、好ましくは１００～１０００ｐｐｍとなるように水で希釈して使用する。 The cleaning and disinfecting agent composition of the present invention contains 1 to 40% by weight, preferably 2 to 30% by weight, more preferably 5 to 20% by weight of the quaternary ammonium salt represented by the general formula (1) in the aqueous solution. provided in different concentrations. Although it is possible to use such an aqueous solution without dilution, it is usually diluted with water so that the quaternary ammonium salt represented by the general formula (1) is 50 to 10000 ppm, preferably 100 to 1000 ppm. to use.
本発明の洗浄除菌剤組成物は病院、食品工場、畜舎、ホテル、レストラン、学校、店舗等の床や壁を洗浄除菌する環境洗浄除菌剤として有用である。
また、食品工場等で使用される食品製造・加工機器や器具の洗浄除菌にも有用である。食品製造・加工機器としては、各種の攪拌機、混合機、ホモジナイザー、自動カッター等が挙げられる。器具としては、まな板、包丁、食品用容器、布巾等が挙げられる。
The cleaning and sanitizing agent composition of the present invention is useful as an environmental cleaning and sanitizing agent for cleaning and sanitizing the floors and walls of hospitals, food factories, barns, hotels, restaurants, schools, stores and the like.
It is also useful for cleaning and sterilizing food manufacturing/processing equipment and utensils used in food factories and the like. Food manufacturing and processing equipment includes various stirrers, mixers, homogenizers, automatic cutters, and the like. Tools include cutting boards, kitchen knives, food containers, cloths, and the like.
本発明の洗浄除菌剤組成物は、長期間保管した場合でも濁りや分離等を起こさず、液性が安定している。 The cleaning and disinfecting agent composition of the present invention does not cause turbidity or separation even when stored for a long period of time, and has stable liquid properties.
以下、実施例により本発明を更に説明する。 The present invention will be further described with reference to the following examples.
実施例１～３および比較例１～５
安定性試験
表１－１および表１－２に示す組成の洗浄除菌剤組成物Ａ～Ｈを調製し、混合直後、１週間保管後、２週間保管後および４週間保管後の安定性（溶状および退色の有無）を目視にて観察した。保管時の温度は０℃および４５℃にて行い、混合直後または保管中に濁りまたは退色したものについては、その時点で試験を中止し、その後の観察は行わなかった。実施例および比較例で使用した第四級アンモニウム塩、両性界面活性剤、非イオン界面活性剤およびビグアナイド化合物は下記の通りである。また、表中の数値は重量％を表す。
Examples 1-3 and Comparative Examples 1-5
Stability test
Cleaning and disinfecting agent compositions A to H having the compositions shown in Tables 1-1 and 1-2 were prepared, and the stability immediately after mixing, after storage for 1 week, after storage for 2 weeks, and after storage for 4 weeks (dissolution and discoloration) presence or absence) was visually observed. The temperatures during storage were 0° C. and 45° C., and if the mixture became cloudy or discolored immediately after mixing or during storage, the test was discontinued at that point, and subsequent observations were not made. The quaternary ammonium salts, amphoteric surfactants, nonionic surfactants and biguanide compounds used in Examples and Comparative Examples are as follows. Further, the numerical values in the table represent % by weight.
第四級アンモニウム塩１：ジデシルメチルポリオキシエチルアンモニウムプロピオン酸塩
第四級アンモニウム塩２：ジデシルジメチルアンモニウムメチル硫酸塩
第四級アンモニウム塩３：ジデシルジメチルアンモニウムアジピン酸塩
第四級アンモニウム塩４：ジデシルジメチルアンモニウム塩酸塩
両性界面活性剤：ヤシ油脂肪酸アミドプロピルジメチルアミノ酢酸ベタイン
非イオン界面活性剤：ポリオキシエチレンオキシプロピレンアルキルエーテル
ビグアナイド化合物：ポリヘキサメチレンビグアナイド塩酸塩
Quaternary ammonium salt 1: Didecylmethylpolyoxyethylammonium propionate Quaternary ammonium salt 2: Didecyldimethylammonium methylsulfate Quaternary ammonium salt 3: Didecyldimethylammonium adipate Quaternary ammonium salt 4: Didecyldimethylammonium hydrochloride Amphoteric surfactant: Coconut fatty acid amidopropyl dimethylaminoacetic acid betaine Nonionic surfactant: Polyoxyethyleneoxypropylene alkyl ether biguanide Compound: Polyhexamethylene biguanide hydrochloride
結果を表１－１および表１－２に示す。組成物Ａ～Ｅは、混合時～４週間保管後まで濁りおよび退色を起こさず安定していた。また、組成物Ｇは混合直後に濁りが発生し、組成物ＦおよびＨは４５℃にて１週間保管後に退色した。表中の「○」は濁りおよび退色が観察されなかったことを示し、「×」は濁りおよび退色が観察されたことを示す。 The results are shown in Tables 1-1 and 1-2. Compositions AE were stable from the time of mixing to after 4 weeks of storage with no turbidity or discoloration. Further, composition G became turbid immediately after mixing, and compositions F and H faded after being stored at 45°C for one week. "O" in the table indicates that turbidity and discoloration were not observed, and "X" indicates that turbidity and discoloration were observed.
殺菌力試験
下記に示す供試菌の胞子懸濁液を調製した（ＪＩＳ Ｚ２９１１：２０１０ かび抵抗性試験方法に準拠）。次に上記安定性試験において問題の無かった洗浄除菌剤組成物Ａ～Ｅを水で表２－１および表２－２に示す濃度に希釈した液１０ｍｌに対し、菌数が１０５ＣＦＵ／ｍｌになるよう生理食塩水で希釈した胞子懸濁液を０．１ｍｌ加えて攪拌した後、０．５、１．０および３．０分間経過後に、各混合物から１白金耳を取り、ＢＨＩブイヨン培地１０ｍｌに接種した。これを３０℃、７２時間培養した。菌未接種のＢＨＩブイヨン培地をコントロールとし、目視で培地の濁りを比較して、供試菌に対する各洗浄除菌剤組成物の殺菌効果を判定した。
Bactericidal power test A spore suspension of the test bacteria shown below was prepared (according to JIS Z2911:2010 mold resistance test method). Next, the cleaning and disinfecting agent compositions A to E, which had no problem in the stability test, were diluted with water to the concentrations shown in Tables 2-1 and 2-2. Add 0.1 ml of the spore suspension diluted to 1 ml with physiological saline and stir. 10 ml of medium was inoculated. This was cultured at 30°C for 72 hours. The turbidity of the medium was visually compared using a BHI bouillon medium not inoculated with bacteria as a control, and the bactericidal effect of each cleaning and disinfecting agent composition on the test bacteria was determined.
（供試菌）
カビ（Ｐｅｎｉｃｉｌｌｉｕｍ ｃｉｔｒｉｎｕｍ ＮＦＲＩ－１０１９）
(test bacteria)
Mold ( Penicillium citrinum NFRI-1019)
結果を表２－１および２－２に示す。３分間感作させた際に殺菌効果を示す薬剤濃度が、組成物Ａ～Ｃが０．０２重量％および０．０４重量％であるのに対し、組成物ＤおよびＥは０．１５重量％となり、カビに対する殺菌効果に劣るものであった。表中の「－」は殺菌効果が確認されたことを示し、「＋」は殺菌効果が確認されなかったことを示す。また表中の薬剤濃度は組成物濃度を表す。 The results are shown in Tables 2-1 and 2-2. The concentration of the drug that exhibits a bactericidal effect when sensitized for 3 minutes is 0.02% by weight and 0.04% by weight for Compositions A to C, whereas 0.15% by weight for Compositions D and E. As a result, the bactericidal effect against mold was inferior. "-" in the table indicates that the bactericidal effect was confirmed, and "+" indicates that the bactericidal effect was not confirmed. Also, drug concentrations in the table represent composition concentrations.
洗浄力試験
上記殺菌力試験において殺菌力に優れていた組成物Ａ～Ｃを第四級アンモニウム塩濃度が３０００ｐｐｍとなるように水で希釈したものを用い、温度３０℃、洗浄時間３分間、すすぎ時間１分間の試験条件でリーナッツ法（ＪＩＳ－Ｋ３３６２）により洗浄力試験を行った。試験は５片のモデル汚れガラス片の重量変化から下記計算式により汚れ除去率を算出し、その平均値を洗浄力とした。
汚れ除去率（％）＝（Ｗ１－Ｗ２）／（Ｗ１－Ｗ０） ｘ１００
Ｗ０：汚れ付着前のガラス片の重量
Ｗ１：汚れ付着後のガラス片の重量
Ｗ２：汚れ付着後のガラス片の洗浄後の重量
Detergency test Compositions A to C, which were excellent in sterilization power in the above sterilization power test, were diluted with water so that the quaternary ammonium salt concentration was 3000 ppm, and rinsed at a temperature of 30 ° C. for 3 minutes. A detergency test was conducted according to the Lean nuts method (JIS-K3362) under test conditions of 1 minute. In the test, the stain removal rate was calculated by the following formula from the change in weight of the five model soiled glass pieces, and the average value was taken as the detergency.
Dirt removal rate (%) = (W1-W2)/(W1-W0) x100
W0: Weight of glass piece before dirt adheres W1: Weight of glass piece after dirt adheres W2: Weight of glass piece after dirt adheres after cleaning
結果を表３に示す。組成物Ａ～Ｃいずれも９５％以上の高い洗浄力を示した。 Table 3 shows the results. All of Compositions A to C exhibited high detergency of 95% or more.
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