[go: up one dir, main page]

JP7033073B2 - 神経変性疾患の予防及び治療において使用するための化合物 - Google Patents

神経変性疾患の予防及び治療において使用するための化合物 Download PDF

Info

Publication number
JP7033073B2
JP7033073B2 JP2018546767A JP2018546767A JP7033073B2 JP 7033073 B2 JP7033073 B2 JP 7033073B2 JP 2018546767 A JP2018546767 A JP 2018546767A JP 2018546767 A JP2018546767 A JP 2018546767A JP 7033073 B2 JP7033073 B2 JP 7033073B2
Authority
JP
Japan
Prior art keywords
compound
treatment
neurodegenerative diseases
pharmaceutical composition
lcn2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018546767A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018535272A5 (he
JP2018535272A (ja
Inventor
ロベルト・コンラート
マルコ・シーレイ
Original Assignee
ウニヴェルシテート・ウィーン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP16156775.5A external-priority patent/EP3207925A1/en
Application filed by ウニヴェルシテート・ウィーン filed Critical ウニヴェルシテート・ウィーン
Publication of JP2018535272A publication Critical patent/JP2018535272A/ja
Publication of JP2018535272A5 publication Critical patent/JP2018535272A5/ja
Priority to JP2021200877A priority Critical patent/JP2022027864A/ja
Application granted granted Critical
Publication of JP7033073B2 publication Critical patent/JP7033073B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2018546767A 2015-11-30 2016-11-30 神経変性疾患の予防及び治療において使用するための化合物 Active JP7033073B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021200877A JP2022027864A (ja) 2015-11-30 2021-12-10 神経変性疾患の予防及び治療において使用するための化合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15196984 2015-11-30
EP15196984.7 2015-11-30
EP16156775.5 2016-02-22
EP16156775.5A EP3207925A1 (en) 2016-02-22 2016-02-22 Compound for use in the prevention and treatment of neurodegenerative diseases
PCT/EP2016/079353 WO2017093363A1 (en) 2015-11-30 2016-11-30 Compound for use in the prevention and treatment of neurodegenerative diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021200877A Division JP2022027864A (ja) 2015-11-30 2021-12-10 神経変性疾患の予防及び治療において使用するための化合物

Publications (3)

Publication Number Publication Date
JP2018535272A JP2018535272A (ja) 2018-11-29
JP2018535272A5 JP2018535272A5 (he) 2020-01-16
JP7033073B2 true JP7033073B2 (ja) 2022-03-09

Family

ID=57539219

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018546767A Active JP7033073B2 (ja) 2015-11-30 2016-11-30 神経変性疾患の予防及び治療において使用するための化合物
JP2021200877A Pending JP2022027864A (ja) 2015-11-30 2021-12-10 神経変性疾患の予防及び治療において使用するための化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021200877A Pending JP2022027864A (ja) 2015-11-30 2021-12-10 神経変性疾患の予防及び治療において使用するための化合物

Country Status (14)

Country Link
US (1) US11179358B2 (he)
EP (2) EP3383381B1 (he)
JP (2) JP7033073B2 (he)
CN (1) CN108601758A (he)
AU (1) AU2016364308B2 (he)
CA (1) CA3003841A1 (he)
DK (1) DK3383381T3 (he)
ES (1) ES2804541T3 (he)
HU (1) HUE050096T2 (he)
IL (1) IL259383B (he)
MX (1) MX2018006631A (he)
PT (1) PT3383381T (he)
SG (2) SG11201803422RA (he)
WO (1) WO2017093363A1 (he)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024112103A1 (ko) * 2022-11-22 2024-05-30 경북대학교 산학협력단 신경염증성 질환 치료효과를 나타내는 신규 펩타이드 및 이의 용도

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3986883A1 (en) * 2019-06-18 2022-04-27 Universität Wien Calixarene compounds and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008509223A (ja) 2004-08-09 2008-03-27 エラン ファーマシューティカルズ,インコーポレイテッド シヌクレイノパシー(synucleinopathic)およびアミロイド生成性疾患の予防および処置
JP2009501922A (ja) 2005-07-21 2009-01-22 ビオメリュー 凝集体形成性循環タンパク質形態を、該形態を凝集させる薬剤及び形成された凝集体を捕捉するための薬剤を用いて検出する方法
JP2009531404A (ja) 2006-03-29 2009-09-03 ウイスタ・ラボラトリーズ・リミテッド タンパク質凝集の阻害物質

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489612A (en) * 1991-08-23 1996-02-06 The University Of Alabama At Birmingham Research Foundation Calixarene chloride-channel blockers
FR2782007B1 (fr) 1998-08-05 2001-02-23 Centre Nat Rech Scient Utilisation des calix(n)arenes pour le traitement des maladies fibrotiques
CN101052417A (zh) * 2004-08-09 2007-10-10 艾兰制药公司 突触核蛋白病以及淀粉样变性病的预防和治疗
WO2013134371A1 (en) 2012-03-06 2013-09-12 Neuropore Therapies, Inc. Methods and compounds to be used in the treatment of neurodegenerative diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008509223A (ja) 2004-08-09 2008-03-27 エラン ファーマシューティカルズ,インコーポレイテッド シヌクレイノパシー(synucleinopathic)およびアミロイド生成性疾患の予防および処置
JP2009501922A (ja) 2005-07-21 2009-01-22 ビオメリュー 凝集体形成性循環タンパク質形態を、該形態を凝集させる薬剤及び形成された凝集体を捕捉するための薬剤を用いて検出する方法
JP2009531404A (ja) 2006-03-29 2009-09-03 ウイスタ・ラボラトリーズ・リミテッド タンパク質凝集の阻害物質

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chem. Soc. Rev,2013年,Vol. 42,pp. 366-386
PNAS,2013年,Vol. 110, No. 10,pp. 4069-4074

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024112103A1 (ko) * 2022-11-22 2024-05-30 경북대학교 산학협력단 신경염증성 질환 치료효과를 나타내는 신규 펩타이드 및 이의 용도

Also Published As

Publication number Publication date
CN108601758A (zh) 2018-09-28
WO2017093363A1 (en) 2017-06-08
EP3383381B1 (en) 2020-04-08
PT3383381T (pt) 2020-07-03
AU2016364308A1 (en) 2018-05-17
SG11201803422RA (en) 2018-06-28
US11179358B2 (en) 2021-11-23
IL259383A (he) 2018-07-31
EP3735965A1 (en) 2020-11-11
AU2016364308B2 (en) 2022-03-10
JP2022027864A (ja) 2022-02-14
JP2018535272A (ja) 2018-11-29
HUE050096T2 (hu) 2020-11-30
EP3383381A1 (en) 2018-10-10
ES2804541T3 (es) 2021-02-08
MX2018006631A (es) 2019-01-30
SG10202004908UA (en) 2020-06-29
IL259383B (he) 2022-07-01
DK3383381T3 (da) 2020-07-13
CA3003841A1 (en) 2017-06-08
US20200360315A1 (en) 2020-11-19

Similar Documents

Publication Publication Date Title
Xia et al. Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system
Canas et al. Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by β-amyloid peptides via p38 mitogen-activated protein kinase pathway
Leung et al. Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats
CN108025006A (zh) 化合物及在治疗衰老相关病症中的用途
JP2022027864A (ja) 神経変性疾患の予防及び治療において使用するための化合物
US11826366B2 (en) Composition and methods for preventing or reducing the incidence of transient ischemic attacks
US20210154156A1 (en) Application of compound in inhibiting ab accumulation and treating alzheimer's disease
Wu et al. CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus
US20210038589A1 (en) Uses, compositions and methods
Cherninskyi et al. Triggering of major brain disorders by protons and ATP: the role of ASICs and P2X receptors
US7964598B2 (en) ApoE4 domain interaction inhibitors and methods of use thereof
Iyaswamy et al. Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease
JP7249433B2 (ja) 蜂毒抽出物を有効成分として含有する神経炎症疾患の予防または治療用組成物
Yan et al. Deoxyschizandrin attenuates Aβ1–42-induced cognitive impairments through up-regulation of AMPA receptors in mice
EP3207925A1 (en) Compound for use in the prevention and treatment of neurodegenerative diseases
CN112888312A (zh) 用于预防或降低短暂性脑缺血发作发病率的组合物及方法
Ensandoust et al. Effect of simultaneous application of adenosine A1 receptor agonist and A2A receptor antagonist on memory, inflammatory factors, and PSD-95 in lipopolysaccharide-induced memory impairment
US20240189307A1 (en) Methods of stabilizing the neuronal proteome against collapse and protecting vascular cells
Hu et al. Patient-derived tau and amyloid-β facilitate long-term depression in vivo: role of tumour necrosis factor-α and the integrated stress response
Kumar et al. The extracellular chaperone clusterin prevents primary and secondary nucleation of an amyloidogenic variant of β2-microglobulin
Fani IDENTIFICATION OF MEMBRANE CA2+ CHANNELS ACTIVATED BY PROTEIN MISFOLDED OLIGOMERS AND THEIR ACTIVATION MECHANISM
CN109310659B (zh) 一种精氨酸或其生理学上可接受的盐在制备用于治疗或预防PolyQ病的药物组合物中的用途
Boerb Friends and Foes in AlzheimerLs Disease
Chen et al. Apoptosis and Autophagy in Acute CNS Injuries: Mechanism and Treatment
US20210121438A1 (en) Methods for treating or preventing conformation diseases and methods for drug screening

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191125

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201207

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210308

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20210810

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211210

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20211210

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20211214

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20220106

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20220111

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220131

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220225

R150 Certificate of patent or registration of utility model

Ref document number: 7033073

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250