JP6944242B2 - Heating device and infusion system - Google Patents

Description

The present invention relates to a heating device and an infusion system.

Hospitals keep blood products refrigerated to maintain the function of blood products that are infused to patients. When infusing a blood product to a patient, the blood product may be warmed to an appropriate temperature and then infused in order to reduce the burden on the patient. Especially when a large amount or critical bleeding occurs, it is necessary to infuse a large amount of blood product in a short time, in which case the blood product is rapidly warmed to the patient's body temperature to prevent hypothermia. There is a need.

Conventionally, an infusion system in which a blood product is infused while being heated has been known for treating a patient who has experienced a large amount of or critical bleeding as described above. Some infusion systems allow a blood product to flow through a heating channel and heat the heating channel with a hot plate using a heater as a heat source (see Patent Document 1).

In the above-mentioned infusion system, in order to rapidly heat a low-temperature blood product, it is necessary to heat the blood product efficiently. For this purpose, for example, it is conceivable to raise the heater temperature to increase the temperature difference between the hot plate and the blood product. However, since blood products become morphologically and functionally abnormal or hemolyzed at high temperatures, there is an upper limit temperature that can be maintained (in a suitable state) so as not to become abnormal or hemolyzed. This upper limit temperature is about 42 ° C., and there is a limit to raising the heater temperature.

In order to efficiently heat a liquid having an upper limit temperature such as a blood product, there is a method of increasing the electric power of the heater part in the hot plate surface in the upstream side heating part rather than the downstream side heating part. (See Patent Document 2).

Japanese Unexamined Patent Publication No. 2015-073848 Japanese Unexamined Patent Publication No. 2015-157041

However, even if the heater power is changed according to the position of the heating flow path as in the above method, if heat is transferred within the hot plate surface, the temperature inside the hot plate surface cannot be controlled and sufficient heating is performed. The temperature efficiency cannot be increased.

This application has been made in view of this point, and one of the purposes of the present application is to provide a heating device and an infusion system capable of efficiently heating a liquid for infusion such as a blood product.

As a result of diligent studies, the present inventors have a structure in which the hot plate suppresses heat transfer between the hot plate regions in which each of the adjacent flow paths in the heating flow path is arranged. As a result, it was found that the above problems could be solved, and the present invention was completed.

That is, the present invention includes the following aspects.
(1) A heating device for heating a liquid for infusion, which has a hot plate and a heating flow path arranged in the surface of the hot plate and through which the fluid flows. A heating device having a structure for suppressing heat transfer between hot plate regions in which each of adjacent flow paths in the heating flow path is arranged.
(2) The heating device according to (1), wherein the hot plate is provided with a slit for suppressing heat transfer.
(3) The heating flow path has a structure in which a plurality of round-trip paths having an outward path and a return path are connected side by side, and the slit is between at least one outward path and the return path adjacent to each other of the plurality of round-trip paths. The heating device according to (2), which is provided at a position corresponding to.
(4) The heating device according to (3), wherein the slit is provided at a position corresponding to at least between the outward path and the return path of the most upstream round-trip path of the heating flow path.
(5) A heater is arranged in the surface of the hot plate, and the hot plate has a structure for suppressing heat transfer between the region where the heater is arranged and another region (1). ) To (4).
(6) The heating device according to (5), wherein the hot plate is provided with a slit for suppressing heat transfer between the region where the heater is arranged and another region.
(7) A heating device for heating a liquid for infusion, wherein the heating flow path through which the liquid flows, a heater, and the heater are arranged on the first surface, and the heating is performed on the second surface. It has a hot plate in which a flow path is arranged and supplies the heat of the heater to the heating flow path, and the hot plate transfers heat between a region in which the heater is arranged and another region. A heating device having a structure that suppresses the use of heat.
(8) The heating device according to (7), wherein a slit for suppressing heat transfer is formed in the hot plate.
(9) In the other region of the hot plate, there is a non-contact temperature sensor that measures the temperature of the inlet of the heating flow path, or a non-contact temperature that measures the temperature of the outlet of the heating flow path. The heating device according to (7) or (8), wherein at least one of the sensors is provided.
(10) An infusion system provided with the heating device according to any one of (1) to (9).

According to the present invention, it is possible to provide a heating device and an infusion system that efficiently heat a liquid for infusion.

It is a schematic diagram which shows the outline of the structure of an infusion system. It is explanatory drawing which shows the outline of the structure of the heating device. It is a partial decomposition view which shows the outline of the structure of a heating device. It is a schematic diagram which shows the outline of the structure of the heating part. It is explanatory drawing which shows the pattern of a heater. It is explanatory drawing which shows the relationship between a heating flow path and a pattern of a heater. It is explanatory drawing which shows the slit of a hot plate. It is explanatory drawing which shows the positional relationship of a slit, a heating flow path and a heater. It is explanatory drawing which shows the other arrangement example of the joint part of a slit. It is a schematic diagram which shows the position where the non-contact type temperature sensor is provided. It is a schematic diagram explaining the state of measuring the temperature of the blood product of a heating flow path by a non-contact type temperature sensor. It is explanatory drawing which shows the example of another structure which suppresses heat transfer. It is explanatory drawing which shows the outline of the structure of the heating device when the heater is provided only on one side of the heating flow path.

Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. The same elements are designated by the same reference numerals, and duplicate description will be omitted. In addition, the positional relationship such as up, down, left, and right shall be based on the positional relationship shown in the drawings unless otherwise specified. Furthermore, the dimensional ratios in the drawings are not limited to the ratios shown. Further, the following embodiments are examples for explaining the present invention, and the present invention is not limited to this embodiment.

FIG. 1 shows an example of the configuration of the infusion system 1. As shown in FIG. 1, the infusion system 1 includes a liquid container 10 for accommodating a blood product as a liquid for infusion, a heating device 11 for heating the blood product, and a bubble removing chamber for removing air bubbles in the blood product. 12, the first flow path 13 connecting the liquid container 10 and the heating device 11, the second flow path 14 connecting the heating device 11 and the bubble removing chamber 12, the bubble removing chamber 12 and the infusion solution to the patient. A third flow path 16 for connecting the infusion unit 15 for performing the above, a fourth flow path 17 for connecting the bubble removing chamber 12 and the liquid container 10, and a first pump 18 provided in the first flow path 13. A second pump 19 provided in the third flow path 16 and a control device 20 and the like are provided.

The liquid container 10 is connected to, for example, a liquid bag 30 that is a source of blood products. The liquid container 10 is provided with a filter 31 for removing unnecessary components of the blood product flowing out to the first flow path 13. The liquid container 10 is made of, for example, a resin, and has a capacity of, for example, 0.5 L or more.

As shown in FIG. 1, a second flow path 14 and a fourth flow path 17 are connected to the upper part of the bubble removal chamber 12, and a third flow path 16 is connected to the lower part of the bubble removal chamber 12.

The first flow path 13, the second flow path 14, the third flow path 16 and the fourth flow path 17 are composed of a soft and flexible tube.

For the first pump 18 and the second pump 19, for example, a tube pump is used. The first pump 18 and the second pump 19 have a liquid feeding capacity of, for example, 100 mL / min or more, preferably 250 mL / min or more, and more preferably 500 mL / min or more. The operation of the first pump 18 and the second pump 19 is controlled by the control device 20.

The control device 20 is, for example, a general-purpose computer, and controls the heating device 11, the first pump 18, the second pump 19, and the like by executing the program recorded in the memory by the CPU, and the infusion system 1 Can perform infusion operations.

As shown in FIGS. 2 and 3, the heating device 11 includes a heating unit 41 having a heating flow path 40 through which a blood product flows, a heating unit 42 that contacts the heating flow path 40 and supplies heat. The heat insulating portion 43 is provided.

The heating portion 41, the heat supply portion 42, and the heat insulating portion 43 are all formed in the shape of a square plate and are laminated. The heating portion 41 is arranged in the center of the laminated structure, the heat supply portions 42 are arranged on both sides of the heating portion 41, and the heat insulating portion 43 is arranged on the outside thereof. Around the heating portion 41, a spacer 44 is provided between the heat supply portions 42 on both sides to secure a space for installing the heating portion 41.

The heating portion 41 is made of a flexible resin and is formed in the shape of a square plate as shown in FIG. The heating flow path 40 is formed, for example, in the shape of a flexible tube, and is formed so as to meander in the heating portion 41. That is, the heating flow path 40 has a shape in which a plurality of round-trip paths are arranged side by side and connected. In the present embodiment, the heating flow path 40 has, for example, six round-trip paths 50, 51, 52, 53, 54, 55 having substantially the same flow path width. The inlet portion 56 and the outlet portion 57 of the heating flow path 40 are provided, for example, at the ends of the heating portion 41 in the same direction.

The heating flow path 40 has a flow path area of ^{200 cm 2 or more.} The "flow path area" is the area of the portion that comes into contact with the heat medium (heat plate 60). The wall of the tube of the heating flow path 40 has a thickness of 0.4 mm or less, preferably 0.3 mm or less, and more preferably 0.2 mm or less.

As shown in FIGS. 2 and 3, the heat supply unit 42 has a hot plate 60 and a heater 61 having a predetermined pattern that generates heat by feeding power. The hot plate 60 is formed in the shape of a square plate having the same shape as the heating portion 41, for example. The heater 61 is provided on the first surface 60a of the hot plate 60, and the heating flow path 40 is in contact with the second surface 60b of the hot plate 60. Therefore, the heat of the heater 61 is transferred to the heating flow path 40 via the hot plate 60.

As shown in FIG. 5, the heater 61 is formed on the hot plate 60 in a predetermined pattern. The heater 61 is supplied with power by the power supply device 62 to generate heat.

As shown in FIG. 6, the heater 61 has a pattern corresponding to the heating flow path 40. The heater 61 is divided into a plurality of regions along a plurality of reciprocating paths 50 to 55 of the heating flow path 40, and the calorific value (heater power) is gradually increased from the upstream region to the downstream region. Arranged to decrease. The heater 61 is divided into, for example, seven regions R1 to R7. For example, in the most upstream round-trip route 50 near the entrance 56, it is divided into three regions R1 to R3. Of these, the outward route 50a is divided into two regions R1 and R2, and the return route 50b is one region R3. The round-trip route 51 (outward route 51a, return route 51b) is one area R4, and the round-trip route 52 (outward route 52a, return route 52b) and the outward route 53a of the round-trip route 53 are one area R5. Further, the return route 53b of the round-trip route 53 and the outward route 54a of the round-trip route 54 are in one area R6, and the return route 54b of the round-trip route 54 and the round-trip route 55 (outward route 55a, return route 55b) are in one region R7. There is.

The heater 61 is, for example, a continuous heating wire, and the calorific value Q of each region R1 to R7 is defined by changing at least one of the density or resistance (for example, thickness, thickness, material, etc.) of the heating wire. There is.

For example, the heaters 61 of the round-trip paths 50, 51, 52, 53 and the outward paths 54a (regions R1 to R6) of the round-trip paths 54 are arranged on the heating flow path 40 along the heating flow path 40. The heaters 61 in the regions R1 to R6 meander in a rectangular shape on the heating flow path 40 from the upstream side to the downstream side and extend. The heaters 61 in the regions R1 to R6 do not protrude from the width of the heating flow path 40 when viewed from a plane.

The return path 54b of the round-trip path 54 and the heater 61 of the round-trip path 55 (region R7) meander in a rectangular shape over the three flow paths.

FIG. 7 is an explanatory view showing an arrangement example of the slits formed in the hot plate 60, and FIG. 8 is an explanatory view showing the positional relationship between the slits of the hot plate 60 and the heating flow path 40 and the heater 61. .. As shown in FIGS. 7 and 8, the hot plate 60 has a structure for suppressing heat transfer between the hot plate regions in which the flow paths adjacent to each other in the heating flow path 40 are arranged. A slit 70 is provided. For example, as shown in FIG. 8, the slit 70 is provided at a position corresponding to the adjacent outward and return paths of all the round-trip paths 50 to 55. Therefore, the slits 70 extend linearly in the outward and return directions (horizontal direction in FIG. 8) of the round-trip paths 50 to 55, and are provided side by side in parallel in the perpendicular direction (vertical direction in FIG. 8). .. Each slit 70 is provided with a connecting portion 71 at the center in the longitudinal direction, for example.

Further, as shown in FIGS. 7 and 8, the hot plate 60 is provided with a slit 80 as a structure for suppressing heat transfer between the region S1 in which the heater 61 is installed and the other region S2. ing. The slit 80 is arranged between, for example, the square region S1 in which the heater 61 is arranged in the hot plate 60 and the outer peripheral region S2 around the square region S1. The slit 80 is formed in a straight line along the four sides of the outer circumference of the square region S1. The slit 80 is formed intermittently and includes a plurality of connecting portions 81.

The slits 70 and 80 are arranged so as not to overlap the position where the heater 61 is located, for example. The slits 70 and 80 may be formed in a bottomed groove shape or may penetrate through the slits 70 and 80. Further, the connecting portion 71 and the connecting portion 81 may be arranged at positions as far as possible from the heater 61 as shown in FIG. 9 in order to suppress heat transfer through the connecting portion.

Next, the operation of the infusion system 1 configured as described above will be described. First, as shown in FIG. 1, the liquid bag 30 in which the low-temperature blood product is stored is connected to the liquid container 10, and the blood product in the liquid bag 30 is stored in the liquid container 10. After that, the first pump 18 and the second pump 19 are operated, and the blood product of the liquid container 10 is sent to the heating device 11 through the first flow path 13. In the heating device 11, the blood product passes through the heating flow path 40, and at that time, the blood product is heated to a predetermined temperature close to the body temperature by the hot plate 60 using the heater 61 as a heat source.

At this time, the heater 61 applies heat to the hot plate 60 so that the amount of heat generated decreases from the upstream side to the downstream side of the heating flow path 40. As a result, the hot plate 60 is maintained at a high temperature at a position corresponding to the upstream portion of the heating flow path 40, and the low-temperature blood product that has entered the heating flow path 40 is more efficient due to the temperature difference from the hot plate 60. It is heated rapidly. The blood product is heated to a desired temperature while flowing through the heating channel 40. At this time, in the hot plate 60, the movement of heat in the plane of the hot plate 60 is suppressed by the slits 70 and 80.

The blood product heated by the heating device 11 passes through the second flow path 14 and flows into the bubble removing chamber 12. The blood product is then passed through the third flow path 16 by the second pump 19 and infused from the infusion unit 15 to the patient. The amount of infusion to the patient is controlled by adjusting the flow rate of the second pump 19.

Bubbles generated in the blood product in the heating device 11 are captured in the bubble removing chamber 12. Some blood products and gases in the bubble removal chamber 12 are returned to the liquid container 10 through the fourth flow path 17. The flow rate of the fluid containing gas passing through the fourth flow path 17 is controlled by adjusting the flow rate of the liquid feed of the first pump 18. For example, by increasing the liquid feed flow rate of the first pump 18, the flow rate of the fluid flowing out from the bubble removing chamber 12 to the fourth flow path 17 is increased, and by reducing the liquid feed flow rate of the first pump 18, bubbles are generated. The flow rate of the liquid flowing out from the removal chamber 12 to the fourth flow path 17 is reduced.

According to the present embodiment, the slit 70 can suppress the transfer of heat between the hot plate regions in which the flow paths adjacent to each other in the heating flow path 40 are arranged, so that each region of the heater 61 can be suppressed. The heat of R1 to R7 is accurately supplied to each portion of the corresponding heating flow path 40, and the blood product can be efficiently heated.

Further, the slit 80 suppresses the diffusion of heat from the region S1 with the heater 61 of the hot plate 60 to the region S2 without the heater 61, and also enters the region S1 with the heater 61 from the region S2 without the heater 61. Is suppressed. As a result, the exchange of heat with the outside of the heater 61 is reduced, and the amount of heat supplied from each region R1 to R7 of the heater 61 to each portion of the heating flow path 40 can be strictly controlled. Further, for example, when the feeding of the blood product in the heating flow path 40 is stopped, heat flows from the region S2 without the heater 61 to the region with the heater 61, and the blood product in the heating flow path 40 is excessively heated. It can be suppressed. In addition, only one of the slit 70 and the slit 80 may be formed on the hot plate 60.

Since the slit 70 is provided at a position corresponding to each other of the round-trip routes 50 to 55 between the adjacent outward and return paths, heat transfer between the adjacent outward and return paths can be appropriately suppressed.

Since the slit 70 is provided at a position corresponding to the outward path 50a and the return path 50b of the uppermost flow path 50 of the heating flow path 40, the amount of heat supplied to the upstream portion of the heating flow path 40 is strictly controlled. Can be controlled. As a result, it is possible to efficiently heat the low-temperature blood product immediately after flowing into the heating flow path 40.

In the above embodiment, as shown in FIGS. 10 and 11, a non-contact temperature sensor that measures the temperature of the blood product at the inlet 56 of the heating flow path 40 in the region S2 of the heating plate 60 without the heater 61. A non-contact temperature sensor 91 that measures the temperature of the blood product at the outlet portion 57 of the heating flow path 40 and 90 may be provided. In such a case, the temperature measurement results of the non-contact temperature sensors 90 and 91 are output to the control device 20, and the control device 20 controls the calorific value of the heater 61 based on the temperature measurement results. Thereby, the temperature of the blood product heated in the heating flow path 40 can be strictly controlled. Further, the region S2 where the temperature of the hot plate 60 is measured is separated from the region R1 where the heater 61 is located by the slit 80, and the region R2 of the hot plate 60 where the temperature is measured is affected by the heat of the heater 61. Hateful. As a result, the non-contact temperature sensors 90 and 91 are suppressed from picking up infrared rays radiated from, for example, the heat plate 60, and the non-contact temperature sensors 90 and 91 are the temperatures of the blood products at the inlet 56 and the outlet 57. Can be measured accurately.

Although preferred embodiments of the present invention have been described above with reference to the accompanying drawings, the present invention is not limited to such examples. It is clear that a person skilled in the art can come up with various modifications or modifications within the scope of the ideas described in the claims, which naturally belong to the technical scope of the present invention. It is understood as a thing.

For example, in the above embodiment, the slit 70 is a structure that suppresses heat transfer between the hot plate regions in which the flow paths adjacent to each other in the heating flow path 40 are arranged, and the heater 61 is arranged. The slit 80 has a structure that suppresses heat transfer between the region S1 and the other region S2, but is not limited to this. For example, as shown in FIG. 12, a material 101 having a higher heat insulating property than the hot plate 60 may be embedded in the holes 100 formed in the hot plate 60 in the same manner as the slits 70 and 80. For the material 101 having high heat insulating properties, for example, an adhesive used for adhering the heater 61 and the hot plate 60 may be used, or a material formed by melting the heater 61 when welding the heater 61 to the hot plate 90 may be used. You may use it.

Further, the predetermined pattern of the heater 61 of the heating device 11 is not limited to the above example. The number of regions in which the heater 61 is divided is not limited to seven and can be arbitrarily selected. Further, the position of the boundary where the heater 61 is divided can be arbitrarily selected. The number and shape of the round-trip paths of the heating flow path 40 are not limited to this. In the above embodiment, the heaters 61 of the heating device 11 are provided on both sides of the heating flow path 40, but as shown in FIG. 13, even if they are provided on only one side of the heating flow path 40. good. That is, the heat supply unit 42 and the heat insulating portion 43 may be provided on one side of the heating portion 41 having the heating flow path 40, and the heat insulating portion 43 may be provided on the other side. The liquid for infusion delivered by the infusion system 1 was a blood product, but is not limited to this, and may be, for example, fresh frozen plasma (FFP), albumin, or extracellular fluid.

The present invention is useful in providing a heating device and an infusion system that efficiently heat a liquid for infusion.

1 Infusion system 11 Heating device 40 Heating flow path 41 Heating unit 42 Heat supply unit 50 to 55 Round trip 60 Hot plate 61 Heater 70 Slit 80 Slit R1 to R7 area

Claims (11)

A heating device that heats the liquid for infusion.
With a hot plate
It is arranged in the hot plate surface and has a heating flow path through which the liquid flows.
The hot plate is a heating device having a structure for suppressing heat transfer between hot plate regions in which hot plates adjacent to each other in the hot plate are arranged. The heating device according to claim 1, wherein the hot plate is provided with a slit for suppressing heat transfer. The heating flow path has a structure in which a plurality of round-trip paths having an outward path and a return path are connected side by side.
The heating device according to claim 2, wherein the slit is provided at a position corresponding to at least one outward path and a return path adjacent to each other of the plurality of round-trip paths. The heating device according to claim 3, wherein the slit is provided at a position corresponding to at least between the outward path and the return path of the most upstream round-trip path of the heating flow path. A heater is arranged in the hot plate surface.
The heating device according to any one of claims 1 to 4, wherein the hot plate has a structure for suppressing heat transfer between a region where the heater is arranged and another region. The heating device according to claim 5, wherein the hot plate is provided with a slit for suppressing heat transfer between the region where the heater is arranged and another region. A heater is arranged on the first surface of the hot plate, and the heating flow path is arranged on the second surface.
The hot plate has a structure that suppresses heat transfer between a region where the heater is arranged and another region, and the structure has a portion that penetrates the hot plate. The heating device according to any one of ~ 4. The heating device according to claim 7, wherein the hot plate is formed with a slit for suppressing heat transfer between the region where the heater is arranged and another region. In the other region of the heating plate, at least a non-contact temperature sensor that measures the temperature at the inlet of the heating flow path or a non-contact temperature sensor that measures the temperature at the outlet of the heating flow path. The heating device according to claim 7 or 8, wherein any of the heating devices is provided. The other region of the hot plate is provided on the outer periphery of the region where the heater is arranged.
Any of claims 7 to 9, wherein the portion penetrating the hot plate is provided between the region where the heater is arranged and the other region so as to surround the region where the heater is arranged. The heating device described in. An infusion system comprising the heating device according to any one of claims 1 to 10.

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