JP6934789B2 - Intraocular lens - Google Patents

Description

The present invention relates to a one-piece, foldable intraocular lens in which an optical portion and a support portion are integrally formed of a soft material.

Intraocular lenses used for the treatment of cataracts and the like have been conventionally known. The intraocular lens is used by being inserted into the inside of the eye excluding the crystalline lens, and has an optical portion that constitutes an ocular optical system with predetermined optical characteristics and a support portion that positions and holds the optical portion in the eye. And have.

Further, the conventional intraocular lens is a three-piece type in which two support parts made of elastic wire are post-fixed to a hard optical part, but in recent years, the optical part and the support part are made of a soft material. An integrally formed one-piece, foldable intraocular lens is provided. With such a one-piece intraocular lens, it is possible to insert the optical portion into the eye through a small incision in a state where the optical portion is folded or rolled up to make it smaller, and the burden on the patient is reduced.

Specifically, for example, using an insertion device as shown in Japanese Patent Application Laid-Open No. 2008-61677 (Patent Document 1), a small folded intraocular lens is inserted into the eye through an insertion tube portion to be inserted into an incision in the eyeball. Can be pushed out and inserted.

However, when the intraocular lens is inserted into the eye using an insertion device, the position of the intraocular lens inserted into the eye is stable because the extruded intraocular lens rotates in the circumferential direction in the insertion tube. There was a problem that it was difficult to do. Therefore, for example, the work of the practitioner for expanding the support portion of the intraocular lens inserted into the eye and setting the optical portion in the normal position may be adversely affected.

Japanese Unexamined Patent Publication No. 2008-16677

Here, the present invention has been made against the background of the above-mentioned circumstances, and the problem to be solved thereof is a one-piece, foldable intraocular lens, which is intraocular using an insertion device. It is an object of the present invention to provide an intraocular lens having a novel structure capable of stabilizing the position of an intraocular lens that is extruded when it is inserted into an intraocular lens.

Hereinafter, aspects of the present invention made to solve such problems will be described. The components adopted in each of the following aspects can be adopted in any combination as much as possible. In addition, the specific aspects or technical features of the present invention are not limited to those described in the following embodiments and embodiments, but those described in the entire specification and drawings, or those described therein. It should be understood that it is recognized based on the invention idea that can be grasped by a person skilled in the art.

In the first aspect of the present invention, an optical portion to which a predetermined optical characteristic is given and a support portion extending from the optical portion toward the outer peripheral side are integrally formed of a soft material that can be folded or rolled up. In the intraocular lens, the optical portion has a substantially oval shape in which two orthogonal axes are a major axis and a minor axis, so that the outer peripheral edges on both sides facing each other in the minor axis direction are the optical portions. The stabilized outer edge portion has a radius of curvature larger than the radial dimension in the minor axis direction, and the extending position of the support portion from the outer peripheral edge of the optical portion is the position of the extension portion of the support portion from the outer peripheral edge of the optical portion. The outer peripheral edge portion that is deviated from the position of the major axis to one side in the circumferential direction and extends in the circumferential direction beyond the major axis at the base end of the support portion is the radial dimension of the optical portion in the major axis direction. It is characterized in that it has a larger radius of curvature and is provided with an overhanging portion that projects to the outer peripheral side of an arc having a radial dimension in the major axis direction .

In an intraocular lens having a structure according to this aspect, the optical portion of the foldable type intraocular lens has a substantially oval shape, so that the outer peripheral edge of the optical portion with respect to the inner peripheral surface of the insertion tube portion of the insertion device. The position of the intraocular lens extruded in the insertion device can be stabilized by utilizing the abutting action of the lens. Specifically, for example, when the intraocular lens is made small so as to be rolled in the insertion tube and extruded, the rotation of the intraocular lens in the insertion tube is suppressed by directing the long axis direction of the intraocular lens in the extruding direction. Can be This is because the outer peripheral edges on both sides having a large radius of curvature extend in the extrusion direction, so that the guiding action is easily exerted, and the short axis shorter than the long axis is curved toward the circumferential direction inside the insertion cylinder. By doing so, the projected area in the extrusion direction can be reduced, and the friction and catching of the peripheral portion at the time of extrusion can be suppressed to a small extent. Further, in the intraocular lens having a structure according to this embodiment, for example, with the long axis of the optical portion oriented in the extrusion direction at the insertion cylinder portion, the tension provided at the base end portion of the support portion located on the rear side. The protrusion may form a pressing surface on which an operating member, such as a plunger, that pushes out the intraocular lens is pressed and an extrusion operating force is exerted.
In the second aspect of the present invention, in the intraocular lens according to the first aspect, an edge portion is formed which extends continuously in the circumferential direction on the outer peripheral edge portion on the rear surface side of the optical portion, and the edge portion is formed. The overhanging portion is provided so as to extend from the portion to the outer peripheral side.
In an intraocular lens having a structure according to this aspect, even if the radius of curvature of the outer peripheral edge of the overhanging portion that partially overhangs to the outer peripheral side in the optical portion becomes small, the edge portion is provided on the inner peripheral side of the overhanging portion. By providing the lens, it is possible to avoid the concentration of local contact force to the sac to which the edge portion is pressed while the lens is embedded in the sac and the occurrence of wrinkles associated therewith.
In the third aspect of the present invention, an optical portion to which a predetermined optical characteristic is given and a support portion extending from the optical portion toward the outer peripheral side are integrally formed of a soft material that can be folded or rolled up. In the intraocular lens, the optical portion has a substantially oval shape in which two orthogonal axes are a major axis and a minor axis, so that the outer peripheral edges on both sides facing each other in the minor axis direction are the optical portions. It is a stabilized outer edge portion having a radius of curvature larger than the radial dimension in the minor axis direction, and on one side in the circumferential direction with respect to the position of the minor axis on the outer peripheral edge of the optical portion, the circumference is A widening portion that extends to the outer periphery with a radius of curvature larger than that of the other side in the direction is integrally formed at the base end of the support portion.
In the intraocular lens having a structure according to this aspect, it is possible to incline the stabilized outer edge portion closer to parallel to the major axis or set it longer in the major axis direction by providing the widening portion. Become. As a result, the guiding action of the stabilized outer edge portion in the lens extrusion direction is improved, and it is possible to more effectively prevent inadvertent rotational displacement in the lens circumferential direction during lens extrusion.

A fourth aspect of the present invention is that in the intraocular lens according to any one of the first to third aspects, the stabilized outer edge portion has a radius of curvature larger than the radial dimension of the optical portion in the major axis direction. It is what you are doing.

In an intraocular lens having a structure according to this aspect, the positions of the intraocular lenses extruded in the insertion device are further stabilized by setting a large radius of curvature on both outer peripheral edges facing each other in the minor axis direction. Can be achieved.

A fifth aspect of the present invention is an intraocular lens according to any one of the first to fourth aspects, wherein in the optical unit, the ratio of the diameter dimension in the minor axis direction to the diameter dimension in the major axis direction is It is set within the range of 60 to 95%.

In an intraocular lens having a structure according to this aspect, it is possible to improve the appearance and the stability of the intraocular position after the intraocular lens is implanted.

A sixth aspect of the present invention is the intraocular lens according to any one of the first to fifth aspects, wherein the stabilized outer edge portion has a length of 1.0 mm or more in the major axis direction. Is.

In an intraocular lens having a structure according to this embodiment, the stabilized outer edge portion having a large radius of curvature has a length of 1.0 mm or more, so that the stabilized outer edge portion of the intraocular lens when extruded into the insertion tube portion is used. The guiding action can be improved, and thus the stabilization of the circumferential position of the intraocular lens can be improved.

A seventh aspect of the present invention is that in the intraocular lens according to any one of the first to sixth aspects, the support portion extends from the optical portion from both side portions in the long axis direction toward the outer peripheral side. It is provided as a pair.

In an intraocular lens having a structure according to this embodiment, support portions protruding outward from the outer peripheral edge of the optical portion are extended from both side portions in the long axis direction of the optical portion, for example, of the optical portion. With the long axis oriented in the pushing direction of the insertion cylinder portion, the support portions on both sides can be arranged so as to extend from the optical portion in the length direction of the insertion cylinder portion. As a result, the support portions on both sides are less likely to get in the way when extruding, and the contact action of the support portions on both sides with the insertion cylinder portion also improves the positional stability of the intraocular lens in the insertion cylinder portion. Can be planned.

In the eighth aspect of the present invention, in the intraocular lens according to any one of the first to seventh aspects, the support portion extends from the optical portion in a substantially J-shaped curved shape, and the support portion extends from the optical portion. A root-side curved portion extending with a constant width dimension is provided at the root portion of the lens, and an intermediate curved portion whose width dimension gradually increases from the root-side curved portion toward the tip is provided, and the intermediate curved portion is provided. The curvature of is smaller than the curvature of the root side bending portion.

In an intraocular lens having a structure according to this embodiment, the root side curved portion has a constant width dimension so that stress is dispersed throughout and the strength characteristics are improved, and the intermediate curved portion has a width. By increasing the size toward the tip, deformation due to contact reaction force in the intraocular insertion state can be suppressed, and after intraocular insertion, the tip of the support part is operated to expand the intraocular lens and position. The operability of the practitioner, such as matching, can be improved.

A ninth aspect of the present invention is that in the intraocular lens according to the eighth aspect, the inner peripheral edge and the outer peripheral edge are concentrically curved in the root-side curved portion, while the intermediate curved portion has a curved shape. , The inner peripheral edge and the outer peripheral edge have the same radius of curvature and a non-concentric curved shape.

In an intraocular lens having a structure according to this aspect, since the curved portion on the root side extends with a constant width dimension and a constant radius of curvature, stress distribution over the entire length direction and thus strength resistance characteristics are further improved. Can be done. Further, since the inner and outer peripheral edges of the intermediate curved portion have the same radius of curvature, it is possible to easily set the spread of the width dimension from the base end to the tip end.

As is clear from the above description, the one-piece, foldable intraocular lens having a structure according to the present invention utilizes the contact action of the outer peripheral edge of the optical portion with respect to the inner peripheral surface of the insertion cylinder portion of the insertion instrument. Therefore, the position of the intraocular lens extruded in the insertion device can be stabilized.

It is a front view which shows the intraocular lens as one Embodiment of this invention. It is a rear view of the intraocular lens shown in FIG. It is a side view which looked at the intraocular lens shown in FIG. 1 from below. It is a cross-sectional view of the intraocular lens shown in FIG. 1, and is the figure corresponding to the Z-axis cross section in FIG. It is a perspective view of the front side of the intraocular lens shown in FIG. It is a perspective view of the back side of the intraocular lens shown in FIG.

Hereinafter, in order to clarify the present invention more concretely, embodiments of the present invention will be described in detail with reference to the drawings.

1 to 6 show an intraocular lens 10 as an embodiment of the present invention. The intraocular lens 10 is a one-piece type that is integrally molded including an optical portion 12 and a pair of support portions 14, 14.

In addition, the intraocular lens 10 having the optical unit 12 and the support portions 14 and 14 has an excellent visible light transmittance sufficient to provide a foldable type intraocular lens. It can be formed of a variety of materials that are soft and have some degree of elasticity. Preferably, it is formed of a soft material having a glass transition temperature of 30 ° C. or lower and a refractive index of 1.51 or higher. With such a soft material, the intraocular lens 10 can be easily folded or rolled up at room temperature to make it more compact, and for example, it can be more easily inserted into the capsule at the time of implantation. ..

Specifically, those described in JP-A-10-24097, JP-A-11-56998, and the like are preferably used as molding materials for the intraocular lens 10 according to the present invention. Among them, in order to obtain an intraocular lens having excellent shape recovery, it is desirable to use a monomer containing one or more (meth) acrylic acid esters as shown in (i) below. In addition, any monomer as shown in (ii) below is appropriately blended. Further, if necessary, additives as shown in the following (iii) are added as necessary.

(I) Monomer-containing monomer Linear, branched or cyclic alkyl (meth) acrylates as described below;
Methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, cyclohexyl (meth) acrylate, etc. Hydroxyl-containing (meth) acrylates such as the following;
Hydroxyethyl (meth) acrylate, hydroxybutyl (meth) acrylate, diethylene glycol mono (meth) acrylate, etc. Aromatic ring-containing (meth) acrylates such as the following;
Phenoxyethyl (meth) acrylate, phenyl (meth) acrylate, phenylethyl (meth) acrylate, etc. Silicon-containing (meth) acrylates such as the following;
Trimethylsiloxydimethylsilylmethyl (meth) acrylate, trimethylsiloxydimethylsilylpropyl (meth) acrylate, etc. "(Meta) acrylate" is a general term for two compounds, "... acrylate" and "... methacrylate". The same applies to other (meth) acrylic derivatives described later.

(Ii) Optional monomer (meth) acrylamide or a derivative thereof, as described below;
(Meta) acrylamide, N, N-dimethyl (meth) acrylamide, etc. N-vinyllactams such as the following;
N-Vinylpyrrolidone, etc. Styrene or derivatives thereof Crosslinkable monomers such as the following;
Butanediol di (meth) acrylate, ethylene glycol di (meth) acrylate

(Iii) Additives Thermal polymerization initiators, photopolymerization initiators, photosensitizers, pigments, etc. Ultraviolet absorbers, etc.

Further, when integrally molding the intraocular lens 10 as shown by using such a monomer material, any of various conventionally known methods can be adopted, for example, a cutting process molding method or a molding method. Alternatively, the target intraocular lens 10 can be obtained by appropriately combining a method of forming an outer periphery by laser processing or punching. According to the cutting method, after polymerizing a predetermined polymerization component made of the above-mentioned monomer material to form a lens blank having an appropriate shape such as a rod shape, a block shape, or a plate shape, the lens blanks are formed by using a lathe or the like. By cutting the lens blanks, an intraocular lens 10 having a desired shape can be obtained. Further, according to the molding method, a predetermined polymerization component made of the above-mentioned monomer material is introduced into the molding cavity by using a molding mold having a molding cavity corresponding to the shape of the target intraocular lens 10. Then, an intraocular lens 10 having a desired shape can be obtained by performing an appropriate polymerization operation there. As the polymerization method of the monomer material, a conventionally known thermal polymerization method, photopolymerization method, or a polymerization method combining them is appropriately adopted depending on the monomer material.

In the intraocular lens 10 integrally molded as described above, the optical portion 12 has a substantially oval shape as a whole when viewed from the front. The substantially entire region of the optical unit 12, particularly the central region, is a lens region having optical characteristics that constitute the optical system of the human eye and perform a function of substituting the crystalline lens of the human eye. The lens surfaces of the optical unit 12 (front surface 18 of the optical unit and rear surface 20 of the optical unit) can have various shapes according to the required optical characteristics, and the shapes of both surfaces 18 and 20 are concave, convex, flat, and the like. Can be set in any combination. In the present embodiment, the optical unit 12 having a convex lens shape in which both the front surface 18 of the optical unit and the rear surface 20 of the optical unit are spherical convex surfaces is adopted.

Here, the optical unit 12 has a reference large circle A having a longest outer diameter as a major axis X, a minimum outer diameter as a minor axis Y, and a major axis x on the major axis X as a diameter with respect to a radial line passing through the geometric center O. And a reference small circle B having a minor axis y on the minor axis Y as a diameter, and a reference ellipse C having a major axis x and a minor axis y orthogonal to each other have a characteristic relationship.

First, in FIG. 1, the reference ellipse C that gives the optical unit 12 is preferably set so that the value of the ellipticity (F = y / x) is within the range of 0.60 ≦ F ≦ 0.95. By adopting the reference ellipse C having such an ellipticity and setting the major axis x and the minor axis y of the optical unit 12, the effective optical system required for the ocular optical system is secured, and a book as described later is used. The effect of the invention can be enjoyed more advantageously.

In particular, the minor diameter y is preferably set within the range of 4 mm ≦ y ≦ 6 mm, and the major diameter x is preferably set within the range of 5 mm ≦ x ≦ 7 mm. If the minor axis y is smaller than 4 mm, edge glare in the minor axis direction is likely to occur, and the possibility of causing a problem in appearance increases. Further, when the major axis x is larger than 7 mm, the area for the support portions 14 and 14 becomes too narrow under the condition that the total length between the outermost outer peripheral ends of both support portions 14 and 14 is generally 12 to 14 mm, and the crystalline lens is formed. The stability and storability in the sac may deteriorate, and it is considered that there is a high possibility of causing poor visibility and late cataract.

Further, as shown in FIG. 1, the outer peripheral edges on both sides of the optical unit 12 facing each other in the direction of the minor axis Y have a radius of curvature r1 larger than the radius dimension y / 2 of the reference small circle B, respectively. The stabilized outer peripheral edge 22 extends in a direction parallel to the substantially major axis X. In particular, in the present embodiment, the radius of curvature r1 of each stabilized outer peripheral edge 22 is made larger than the radius dimension x / 2 of the reference great circle A, and is closer to parallel to the major axis X.

It should be noted that the region of the stabilized outer peripheral edge 22 having at least a radius of curvature larger than the radius dimension of the reference small circle B, the inclination angle with respect to the major axis X being smaller than that of the minor axis Y, and extending in the direction of the major axis X. Is preferably 1/5 or more of the major axis x in the major axis X direction, and more preferably is provided over 1/3 or more of the major axis x. Specifically, in a general intraocular lens implanted in the lens capsule, it is desirable that the length of the stabilized outer peripheral edge 22 in the major axis X direction is 1 mm or more. As a result, the position stability effect described later can be further improved.

On the other hand, the outer peripheral edges on both sides of the optical unit 12 facing each other in the direction of the long axis X are also formed with a radius of curvature r2 larger than the radius dimension y / 2 of the reference small circle B, respectively.

The thickness dimension of the optical unit 12 in the optical axis direction (vertical direction in FIG. 4): d is preferably 0.10 to 2.00 mm at the maximum value, and more preferably 0 at the maximum value. .20 to 1.50 mm. If the maximum value of the wall thickness dimension of the optical unit 12 is less than 0.10 mm, the shape retention performance of the optical unit 12 under the embedded state may not be stably exhibited, while the optical unit 12 may not be exhibited stably. If the maximum value of the wall thickness dimension exceeds 2.00 mm, it may be difficult to fold or wind the optical portion 12 sufficiently small when inserting it into the capsule. In this embodiment, the biconvex optical unit 12 has a maximum wall thickness on the optical axis, which is the geometric center. Further, the specific value of the maximum wall thickness dimension: d is designed by comprehensively considering the characteristics (softness, refractive index, etc.) of the material to be used, the shape, size, etc. of the optical unit 12. ..

Further, a pair of support portions 14, 14 extending with a predetermined length toward the outer peripheral side are integrally provided on the outer peripheral edge of the optical portion 12. These support portions 14 and 14 are both sides of the optical unit 12 in the long axis X direction, and extend from the outer peripheral portion extending substantially in the vertical direction on both sides in the left-right direction in FIG. It is formed as a curved tactile protrusion.

Each support portion 14 has a substantially J-shaped curved shape as a whole and extends toward the outer periphery of the optical portion 12. The root portion of the support portion 14 corresponding to the lower part of the J-shape is a root-side curved portion 28 that has a concentric inner peripheral edge 24 and an outer peripheral edge 26 and extends at a predetermined length with a constant width dimension L. ing. In particular, in the present embodiment, both the inner peripheral edge 24 and the outer peripheral edge 26 have an arc shape, and the root side curved portion 28 has an arc plate shape having a constant width and a length less than half a circumference.

Further, in the support portion 14, the portion extending from the root side curved portion 28 toward the tip side and extending from the middle to the tip of the support portion 14 corresponding to the J-shaped vertical line portion has a smaller curvature than the root side curved portion 28. It is said to be an extending intermediate curved portion 30. The connection points of the root side curved portion 28 and the intermediate portion curved portion 30 have the same width dimension and are connected with a common tangent, so that they are connected with a smooth surface without steps or corners. Further, the root side curved portion 28 and the intermediate portion curved portion 30 have a substantially constant thickness dimension as a whole.

The width of the intermediate curved portion 30 gradually and continuously increases from the root-side curved portion 28 toward the tip. In particular, in the present embodiment, both the inner peripheral edge 32 and the outer peripheral edge 34 of the intermediate curved portion 30 have an arc shape, and the radius of curvature c of the inner peripheral edge 32 and the radius of curvature of the outer peripheral edge 34 are the same. However, by making the center of curvature different, a shape in which the width dimension gradually increases toward the tip side is realized.

At the tip of the support portion 14, the tip portion 38 is provided by widening the tip of the intermediate portion curved portion 30 toward the inner circumference side with a substantially semicircular shape having a radius of curvature e. The outer peripheral edge of the cutting edge portion 38 smoothly connects the inner peripheral edge 32 and the outer peripheral edge 34 of the intermediate curved portion 30. The radius of curvature e of the most advanced portion 38 is slightly larger than the width dimension of the tip portion of the intermediate portion curved portion 30.

By the way, in the present embodiment, the center position of each base end of the pair of support portions 14, 14 on the outer peripheral edge of the optical portion 12 is located on one side in the circumferential direction by an angle θ in the circumferential direction from the long axis X of the optical portion 12. It is biased toward the clockwise side in FIG. 1. In other words, the facing direction Z of the protruding positions of the pair of support portions 14, 14 from the optical portion 12 is inclined by an angle θ with respect to the long axis X.

Further, in the root-side curved portion 28 of the support portion 14, the arc-shaped inner peripheral edge 24 is smoothly connected to the outer peripheral edge of the optical portion 12 in the substantially tangential direction on the substantially long axis X. On the other hand, the arcuate outer peripheral edge 26 of the root-side curved portion 28 of the support portion 14 has a curvature opposite to the root-side curved portion 28 at an inflection point set in the middle portion in the circumferential direction of the root-side curved portion 28. By shifting the center to form an inverted radius, the outer peripheral edge 26'on the proximal end side extends toward the optical portion 12 with a concave outer peripheral arc shape having a radius of curvature f.

In the present embodiment, the radius of curvature f is f> b> a with respect to the radius of curvature a and b of the inner and outer peripheral edges of the root side curved portion 28. Further, the base end side outer peripheral edge 26', which has an inverted circular arc shape in the root side curved portion 28 of the support portion 14, is a point on the long axis X and a point on the minor axis Y on the outer peripheral edge of the optical portion 12. It extends to a substantially intermediate portion (around θ≈45 degrees) and is smoothly connected to the outer peripheral edge of the optical unit 12 in a substantially tangential direction.

By setting the shapes of the inner and outer peripheral edges 24 and 26 with respect to the base end portion of the root side curved portion 28 of the support portion 14, the width dimension is substantially constant from the base end side of the intermediate portion curved portion 30. The base end portion of the root side curved portion 28 extending toward the optical portion 12 side has a shape that is widened on both sides in the circumferential direction toward the optical portion 12 in the front view of FIG. 1, and is supported by such a portion. A connecting portion 40 with respect to the optical portion 12 of the portion 14 is configured.

Further, on the outer peripheral edge of the optical unit 12, the inner peripheral edge 24 of the support unit 14 is in contact with each other on substantially the X-axis, but the outer peripheral edge of the optical unit 12 is on the side opposite to the support unit 14 in the circumferential direction with the contact point interposed therebetween. Is provided with an overhanging portion 42 overhanging on the outer peripheral side. The overhanging portion 42 has a radius of curvature larger than the radius of curvature of the reference ellipse C described above and a radius of curvature larger than the radius of curvature of the reference great circle A, and is a support portion in a direction substantially orthogonal to the X axis. It has an outer peripheral edge 44 extending in the circumferential direction opposite to 14.

The outer peripheral edge 44 of the overhanging portion 42 may have a regular radius shape having a center of curvature on the optical center axis side, a linear shape, or a reverse radius shape. Further, the overhanging portion 42 is integrally formed on the outer peripheral portion of the optical portion 12, but since it overhangs from the optical portion 12 to the outer peripheral portion, the overhanging portion 42 is required by the ocular optical system. Optical characteristics do not necessarily have to be set.

On the other hand, in the outer peripheral portion of the optical portion 12 to which the outer peripheral edge 26 ′ having an inverted radius shape is connected at the base end portion of the support portion 14, the outer peripheral edge 26 ′ is more smoothly connected to the outer peripheral edge of the optical portion 12. As described above, the enlarged diameter portion 46 has a slightly larger outer diameter dimension. That is, in FIG. 1, in the stabilized outer peripheral edge 22 located above the X axis, the portion located on the left side of the Y axis and to which the outer peripheral edge 26'of the support portion 14 is connected is larger than the opposite Y axis. The radius of curvature is made larger than the portion located on the right side, and the enlarged diameter portion 46 has a large diameter as a whole. Similarly, in FIG. 1, in the stabilized outer peripheral edge 22 located below the X axis, the portion located on the right side of the Y axis and connected to the outer peripheral edge 26'of the support portion 14 is the opposite Y axis. The radius of curvature is made larger than the portion located on the left side, and the enlarged diameter portion 46 has a large diameter as a whole.

Then, in the present embodiment, in each stabilized outer peripheral edge 22 of the optical unit 12, the overhanging portion 42 is provided on one side in the circumferential direction and the enlarged diameter portion 46 is provided on the other side, whereby such stabilization is performed. The circumferential length of the outer peripheral edge 22 is secured more advantageously, and the radius of curvature is further increased. As a result, the stabilized outer peripheral edges 22 and 22 are provided at an inclination angle closer to parallel to the X-axis and over a longer region, respectively.

Further, each of the support portions 14 is formed with substantially flat surfaces whose front and back surfaces extend in the direction perpendicular to the optical axis, but as shown in FIGS. Each support portion 14 is provided on one side (18 side on the front surface of the optical portion) with a slight deviation. The connecting portion 40 of each support portion 14 is formed with an inclined surface having a surface on one side (front surface 18 side of the optical unit) in the optical axis direction gradually toward the front surface side in the optical axis direction toward the outer peripheral side.

As a result, the contact reaction force of the outer peripheral edges 34, 34 of the support portions 14, 14 that come into contact with the sac when implanted in the eye acts on the optical portion 12 in a biased manner in the central axial direction. Therefore, a component force for pressing the optical unit 12 toward the posterior capsule side is applied. As a result, the rear surface 20 of the optical unit 12 is pressed against the posterior capsule and becomes stable.

Further, an edge portion 50 having a corner having a substantially right-angled cross section is provided on the outer peripheral edge of the rear surface 20 of the optical portion 12. The edge portion 50 extends continuously and smoothly over the entire circumference in the circumferential direction so as to surround the optical portion 12. The edge portion 50 in the present embodiment is formed on the same plane extending in the direction perpendicular to the optical axis over the entire circumference.

It should be noted that the smooth extension of the edge portion 50 means that a polygonal point or a polygonal line is formed over the entire circumference by connecting a function curve or a plurality of curves or straight lines (including all aspects of these appropriate combinations). It is formed so as not to include it. In particular, in the present embodiment, the edge portion 50 is formed so as to extend not the outer peripheral edge but the inner peripheral side of the overhanging portion 42 with respect to the overhanging portion 42 which is the portion having the smallest radius of curvature on the outer peripheral edge of the optical portion 12. As a result, the minimum radius of curvature of the edge portion 50 in the circumferential direction is set large. Incidentally, increasing the minimum radius of curvature in the circumferential direction of the edge portion 50 is preferable for the purpose of suppressing wrinkles in the posterior capsule in the implanted state and reducing the occurrence of late cataract.

The intraocular lens 10 having the above-mentioned structure can be reduced in size by folding or winding the entire lens 10 including the optical unit 12 and the support portions 14 and 14 in an appropriate direction. NS. Then, as is well known, a part of the human eye is incised, the crystalline lens is removed from the incision by suction or the like, and then a miniaturized intraocular lens 10 is inserted into the sac through such an incision. Insert it. This insertion operation is generally performed by inserting the intraocular lens 10 into the sac through a small-diameter insertion tube whose tip is inserted into the eye through an incision using a manually operable insertion device.

In particular, in the present embodiment, the intraocular lens 10 is formed in a direction substantially orthogonal to the opposite direction of the pair of support portions 14, 14 by setting a line substantially parallel to the X axis in FIG. 1 as a folding line or a winding center line. The intraocular lens 10 can be folded or rolled up (including rounding, rolling, etc.) to form a long length in the protruding direction of the support portions 14, 14 so that the intraocular lens 10 can be extruded through a small-diameter insertion cylinder portion. It is possible to advantageously realize the reduction in size of the lens. That is, in the present embodiment, the pair of connecting portions 40, 40 are projected in one direction in the radial direction of the optical portion 12 in which the pair of supporting portions 14, 14 are projected. In the winding direction, the connecting portions 40, 40 projecting to the outer peripheral side of the optical portion 12 are not formed, and the size is kept small. Therefore, even if the connecting portions 40, 40 are provided, the projected area of the pair of supporting portions 14, 14 in the intraocular insertion direction in the protruding direction can be sufficiently reduced by folding or winding, and the inside of the capsule can be sufficiently reduced. It is possible to keep the incision small at the time of insertion into.

Here, in the intraocular lens 10 as described above, the stabilized outer peripheral edges 22 and 22 provided on the outer peripheral edge portion of the optical portion 12 serve as a polygonal line or the like when the size is reduced for intraocular insertion. It extends almost parallel to. In particular, in the present embodiment, the radius of curvature r1 of each stabilized outer peripheral edge 22 is made larger than the radius dimension x / 2 of the reference great circle A, and is closer to parallel to the major axis X. Therefore, the intraocular lens 10 is accommodated in a state where these stabilized outer peripheral edges 22 and 22 extend along the central axis in the extrusion direction in the insertion tube portion, and when extruded in the insertion tube portion, the intraocular lens 10 is accommodated. , The frictional force and the contact reaction force of the stabilized outer peripheral edges 22 and 22 with respect to the inner surface of the insertion cylinder exert a guiding action, so that the intraocular lens 10 is unintentionally tilted (for example, rotation in the lens circumferential direction) in the insertion cylinder. Displacement) can be suppressed and stability in the extrusion direction can be improved.

Further, in the present embodiment, in the outer peripheral portion of the optical portion 12, the overhanging portion 42 and the enlarged diameter portion 46 are provided with a structure extending to the outer peripheral side, so that the stabilized outer peripheral edge 22 is further along the X axis. Since it is formed in an elongated shape, the guiding action of the stabilized outer peripheral edges 22 and 22 during the extrusion operation of the intraocular lens 10 as described above is further improved.

Further, in the above-mentioned intraocular lens 10, the pair of support portions 14 and 14 are provided at positions on the outer peripheral edge of the optical portion 12 that are deviated from the X-axis in the circumferential direction and are deviated in the deviating direction of the support portions 14. An overhanging portion 42 is provided on the opposite side of the X-axis, thereby forming an outer peripheral edge 44 extending from the vicinity of the X-axis toward the opposite side of the support portion in a direction substantially orthogonal to the X-axis. Has been done. Therefore, the outer peripheral surface of the outer peripheral edge 44 provides a pressing surface that abuts the tip of the plunger (extruded shaft member) for extruding the intraocular lens 10 housed in the insertion tube portion of the insertion instrument to exert an pushing force. It can be configured advantageously. Then, by exerting the pressing force of the intraocular lens 10 on the outer peripheral edge 44, the pushing force can be easily and efficiently and stably exerted on the intraocular lens 10, which is a burden on the practitioner. Reduction can also be achieved.

In the present embodiment, the above-mentioned overhanging portion 42 is provided so as to extend to the outer peripheral side of the edge portion 50 of the optical portion 12. As a result, the radius of curvature of the edge portion 50 in the circumferential direction is prevented from becoming too small by providing the overhanging portion 42, and the overhanging portion 42 presses the edge portion 50 to extend in the circumferential direction at an inclination close to parallel to the Y axis. The outer peripheral edge 44 as a surface can be set more advantageously. Further, in the present embodiment, the outer peripheral surface of the overhanging portion 42 is widened in the axial direction (the thickness dimension of the outer peripheral edge is larger than the thickness dimension of the inner peripheral edge of the overhanging portion 42). The contact area with the inner surface of the sac under the state of being implanted in the eye is increased to reduce the contact pressure, and the sac with respect to the curved portion of the edge portion 50 provided on the inner peripheral edge of the overhanging portion 42. The contact pressure is dispersed and relaxed by the outer peripheral surface of the overhanging portion 42, and the occurrence of wrinkles in the sac at the contact portion of the edge portion 50 can be further reduced.

Further, in the present embodiment, since the root-side curved portion 28 of the support portion 14 has a substantially constant width dimension over a predetermined length, stress is dispersed over substantially the entire width and buckling occurs. Bending of the shape is prevented. Furthermore, the intermediate curved portion 30 of the support portion 14 is wider than the root side curved portion 28, and is gradually widened toward the tip on which the contact reaction force to the sac directly acts. As a result, the contact reaction force with the sac at the support portion 14 is dispersed or buffered.

Then, in addition to the interaction between the root side curved portion 28 and the intermediate portion curved portion 30, the connecting portion 40, which is the connecting portion of the support portion 14 to the optical portion 12, is widened to suppress the occurrence of distortion. In addition, the support portion 14 is deflected to the front side in the axial direction with respect to the optical portion 12 so that the connection portion with the optical portion 12 is thinned (see FIG. 4), so that the support portion 14 can be optically used. It is also possible to reduce the transmission of stress and strain to the portion 12 and effectively prevent the occurrence of disturbance of optical characteristics such as astigmatism due to such strain.

Further, in the present embodiment, the front surface 18 is a spherical crown-shaped convex curved surface having a smaller radius of curvature than the rear surface 20 of the optical unit 12. Therefore, by increasing the radius of curvature of the rear surface 20 while realizing the optical characteristics required for the optical unit 12 by the front and rear surfaces 18 and 20, the outer peripheral edge portion of the optical unit rear surface 20 spreads substantially parallel to the optical axis. The corner of the edge portion 50 formed between the outer peripheral surface of the optical portion and the outer peripheral surface of the optical portion can be set to a shape closer to a right angle so as to be effective in suppressing late-onset cataracts.

Further, in the present embodiment, regarding the specific shapes of the inner and outer peripheral edges of the support portions 14 and 14, many arc shapes are formed in the inner and outer peripheral edges 24 and 26 of the root side curved portion 28 and the inner and outer peripheral edges 32 and 34 of the intermediate portion curved portion 30. By adopting it, it is possible to facilitate design and manufacturing.

Although the embodiments of the present invention have been described in detail above, the present invention is not limited to the specific structure of the embodiments. For example, the overhanging portion 42, the enlarged diameter portion 46, and the like are not always necessary, and it is possible to adopt only one of them.

Further, the specific shape and number of the support portions 14 are not particularly limited, and support portions having various known shapes can be adopted in the present invention.

In addition, although not listed one by one, the present invention can be implemented in a mode in which various changes, modifications, improvements, etc. are added based on the knowledge of those skilled in the art, and such an embodiment is the present invention. Needless to say, all of them are included in the scope of the present invention as long as they do not deviate from the gist of the present invention.
Further, the present invention originally includes all of the inventions described in the following (i) to (x), and the configuration and the action and effect thereof will be added.
The present invention
(I) In an intraocular lens in which an optical portion to which a predetermined optical characteristic is given and a support portion extending from the optical portion toward the outer peripheral side are integrally formed of a soft material that can be folded or rolled up. The optical portion has a substantially oval shape in which two orthogonal axes are a major axis and a minor axis, so that the outer peripheral edges on both sides facing each other in the minor axis direction are in the minor axis direction of the optical portion. An intraocular lens characterized by having a stabilized outer edge having a radius of curvature larger than the radial dimension,
(Ii) The intraocular lens according to (i), wherein the stabilized outer edge portion has a radius of curvature larger than the radial dimension of the optical portion in the major axis direction.
(Iii) The intraocular lens according to (i) or (ii), wherein the ratio of the diameter dimension in the minor axis direction to the diameter dimension in the major axis direction is set in the range of 60 to 95% in the optical unit. lens,
(Iv) The intraocular lens according to any one of (i) to (iii), wherein the stabilized outer edge portion has a length of 1.0 mm or more in the long axis direction.
(V) The intraocular lens according to any one of (i) to (iv), wherein the support portion is provided as a pair extending from both side portions in the long axis direction from the optical portion toward the outer peripheral side. lens,
(Vi) The extending position of the support portion from the outer peripheral edge of the optical portion is deviated from the position of the long axis on the outer peripheral edge of the optical portion to one side in the circumferential direction, and the base of the support portion. The outer peripheral edge portion extending in the circumferential direction beyond the major axis at the end has a radius of curvature larger than the radial dimension of the optical portion in the major axis direction, and is more than an arc having a radial dimension in the major axis direction. The intraocular lens according to any one of claims (i) to (v), which is provided with an overhanging portion extending to the outer peripheral side.
(Vi) An edge portion is formed which extends continuously in the circumferential direction from the outer peripheral edge portion on the rear surface side of the optical portion, and the overhanging portion is provided so as to extend from the edge portion to the outer peripheral side (vii). The intraocular lens described in vi),
(Viii) The support portion extends from the optical portion in a substantially J-shaped curved shape, and a root side curved portion extending with a constant width dimension is provided at the root portion of the support portion, and the root side is provided. An intermediate curved portion whose width dimension gradually increases from the curved portion toward the tip is provided, and the curvature of the intermediate curved portion is made smaller than the curvature of the root side curved portion (i) to (vii). The intraocular lens according to any one of the above,
(Ix) In the root side curved portion, the inner peripheral edge and the outer peripheral edge have a concentric curved shape, while in the intermediate curved portion, the inner peripheral edge and the outer peripheral edge have the same radius of curvature and a non-concentric curved shape. The intraocular lens described in (vivi),
(X) On one side in the circumferential direction with respect to the position of the minor axis on the outer peripheral edge of the optical portion, a widening portion extending to the outer periphery with a radius of curvature larger than that on the other side in the circumferential direction is provided on the support portion. The intraocular lens according to any one of (i) to (ix) integrally formed at the proximal end.
Including inventions related to.
In the invention described in (i) above, in the foldable type intraocular lens, the optical portion has a substantially oval shape, so that the outer peripheral edge of the optical portion is in contact with the inner peripheral surface of the insertion tube portion of the insertion instrument. The contact action can be used to stabilize the position of the intraocular lens that is extruded within the insertion device. Specifically, for example, when the intraocular lens is made small so as to be rolled in the insertion tube and extruded, the rotation of the intraocular lens in the insertion tube is suppressed by directing the long axis direction of the intraocular lens in the extruding direction. Can be This is because the outer peripheral edges on both sides having a large radius of curvature extend in the extrusion direction, so that the guiding action is easily exerted, and the short axis shorter than the long axis is curved toward the circumferential direction inside the insertion cylinder. By doing so, the projected area in the extrusion direction can be reduced, and the friction and catching of the peripheral portion at the time of extrusion can be suppressed to a small extent.
In the invention described in (ii) above, the positions of the intraocular lenses extruded in the insertion instrument can be further stabilized by setting a large radius of curvature for the outer peripheral edges on both sides facing each other in the minor axis direction. Can be planned.
In the invention described in (iii) above, it is possible to improve the appearance and the stability of the intraocular position after the intraocular lens is implanted.
In the invention described in (iv) above, the stabilized outer edge portion having a large radius of curvature has a length of 1.0 mm or more, so that the guiding action of the stabilized outer edge portion of the intraocular lens when the inside of the insertion tube portion is extruded. As a result, the stabilization of the circumferential position of the intraocular lens can be improved.
In the invention described in (v) above, the support portions protruding outward from the outer peripheral edge of the optical portion are extended from both side portions in the long axis direction of the optical portion, whereby, for example, the long axis of the optical portion. Can be arranged so that the support portions on both sides extend from the optical portion in the length direction of the insertion cylinder portion in a state of being directed in the pushing direction of the insertion cylinder portion. As a result, the support portions on both sides are less likely to get in the way when extruding, and the contact action of the support portions on both sides with the insertion cylinder portion also improves the positional stability of the intraocular lens in the insertion cylinder portion. Can be planned.
In the invention described in (vi) above, for example, in a state where the long axis of the optical portion is directed in the extrusion direction at the insertion cylinder portion, the overhanging portion provided at the base end portion of the support portion located on the rear side is used. An operating member such as a plunger that pushes out the intraocular lens may be pressed against it to form a pressing surface on which the extrusion operating force is applied.
In the invention described in (vii) above, even when the radius of curvature of the outer peripheral edge of the overhanging portion that partially overhangs to the outer peripheral side in the optical portion becomes small, the edge portion is provided on the inner peripheral side of the overhanging portion. As a result, it is possible to avoid the concentration of local contact force to the sac to which the edge portion is pressed while the lens is embedded in the sac and the occurrence of wrinkles associated therewith.
In the invention described in the above (viii), the root side curved portion has a constant width dimension so that stress is dispersed throughout and the strength characteristics are improved, and the intermediate curved portion has a width dimension. By increasing the size toward the tip, deformation due to contact reaction force in the intraocular insertion state can be suppressed, and after intraocular insertion, the tip of the support portion is operated to expand or align the intraocular lens. It is possible to improve the operability of the practitioner.
In the invention described in (ix) above, since the root-side curved portion extends with a constant width dimension and a constant radius of curvature, stress distribution over the entire length direction and thus strength resistance characteristics can be further improved. .. Further, since the inner and outer peripheral edges of the intermediate curved portion have the same radius of curvature, it is possible to easily set the spread of the width dimension from the base end to the tip end.
In the invention described in (x) above, the provision of the widening portion makes it possible for the stabilized outer edge portion to be inclined closer to parallel to the major axis or to be set longer in the major axis direction. As a result, the guiding action of the stabilized outer edge portion in the lens extrusion direction is improved, and it is possible to more effectively prevent inadvertent rotational displacement in the lens circumferential direction during lens extrusion.

10: Intraocular lens, 12: Optical part, 14: Support part, 18: Front side of optical part, 20: Rear surface of optical part, 22: Stabilized outer peripheral edge (stabilized outer edge part), 24: Inner peripheral edge (at root part) , 26: Outer peripheral edge (at the root part), 28: Root side curved part (root part), 30: Intermediate curved part, 32: Inner peripheral edge (in the middle curved part), 34: Outer peripheral edge (intermediate curved part) ), 38: Cutting edge part, 40: Connecting part (base end of support part), 42: Overhanging part, 44: Outer peripheral edge (of overhanging part), 46: Enlarged diameter part, 50: Edge part

Claims (9)

In an intraocular lens in which an optical portion to which a predetermined optical characteristic is given and a support portion extending from the optical portion toward the outer peripheral side are integrally formed of a foldable or rollable soft material.
The optical portion has a substantially oval shape in which two orthogonal axes are a major axis and a minor axis, so that the outer peripheral edges on both sides facing each other in the minor axis direction are in the minor axis direction of the optical portion. It is said to be a stabilized outer edge having a radius of curvature larger than the radius dimension in
The extension position of the support portion from the outer peripheral edge of the optical portion is biased to one side in the circumferential direction from the position of the long axis on the outer peripheral edge of the optical portion, and the support portion is located at the base end of the support portion. The outer peripheral edge extending in the circumferential direction beyond the major axis has a radius of curvature larger than the radial dimension of the optical portion in the major axis direction, and is on the outer peripheral side of the arc having the radial dimension in the major axis direction. An intraocular lens characterized by having an overhanging portion that overhangs the radius. According to claim 1 , an edge portion is formed which extends continuously in the circumferential direction from the outer peripheral edge portion on the rear surface side of the optical portion, and the overhanging portion is provided so as to extend from the edge portion to the outer peripheral side. The described intraocular lens. In an intraocular lens in which an optical portion to which a predetermined optical characteristic is given and a support portion extending from the optical portion toward the outer peripheral side are integrally formed of a foldable or rollable soft material.
The optical portion has a substantially oval shape in which two orthogonal axes are a major axis and a minor axis, so that the outer peripheral edges on both sides facing each other in the minor axis direction are in the minor axis direction of the optical portion. It is said to be a stabilized outer edge having a radius of curvature larger than the radius dimension in
On one side in the circumferential direction with respect to the position of the minor axis on the outer peripheral edge of the optical portion, a widening portion extending to the outer periphery with a radius of curvature larger than that of the other side in the circumferential direction is provided at the base end of the support portion. An intraocular lens characterized by being integrally formed. The intraocular lens according to any one of claims 1 to 3, wherein the stabilized outer edge portion has a radius of curvature larger than the radial dimension of the optical portion in the major axis direction. The intraocular lens according to any one of claims 1 to 4, wherein in the optical unit, the ratio of the diameter dimension in the minor axis direction to the diameter dimension in the major axis direction is set within the range of 60 to 95%. lens. The intraocular lens according to any one of claims 1 to 5 , wherein the stabilized outer edge portion has a length of 1.0 mm or more in the long axis direction. The intraocular lens according to any one of claims 1 to 6 , wherein the support portion is provided as a pair extending from both side portions in the long axis direction toward the outer peripheral side from the optical portion. The support portion extends from the optical portion in a substantially J-shaped curved shape, and a root side curved portion extending with a constant width dimension is provided at the root portion of the support portion, and the root side curved portion extends from the root side curved portion. Any one of claims 1 to 7, wherein an intermediate curved portion whose width dimension gradually increases toward the tip is provided, and the curvature of the intermediate curved portion is smaller than the curvature of the root side curved portion. Intraocular lens described in. In the root side curved portion, the inner peripheral edge and the outer peripheral edge have a concentric curved shape, while in the intermediate curved portion, the inner peripheral edge and the outer peripheral edge have the same radius of curvature and a non-concentric curved shape. The intraocular lens according to claim 8.

Images