JP6860734B2 - Liquid cleaning agent composition - Google Patents

Description

The present invention is a cleaning agent composition that can be used mainly for cleaning hands and fingers, and more specifically, a cleaning agent composition having excellent detergency, bactericidal effect, virus inactivating effect, and less skin irritation. Regarding.

There have been various conventional methods for cleaning and sterilizing the hands of employees in the food-related industry such as meat and seafood processing and restaurant kitchens, as well as doctors, nurses, caregivers, and patients at hospitals and health centers. It has been taken. The most common method is to first wash the fingers thoroughly with a cleaning agent for fingers, and then sterilize the fingers by immersing them in a disinfectant or spraying them. These methods can be said to be effective methods when they are faithfully performed according to the cleaning and sterilization manuals. However, if the hands and fingers are not sufficiently washed, there is a problem that the bactericidal power due to the subsequent sterilization treatment is extremely reduced, and microorganisms that cause food poisoning may be brought to the site.

In recent years, the number of cases of food poisoning caused by norovirus and the number of patients have been increasing in the food poisoning outbreak situation, and it has become a big problem due to its high infectivity. The cause of food poisoning due to norovirus is not only the factor of eating bivalves such as oysters, but also the secondary infection caused by contact with human feces, vomit, and other foods.

In order to prevent the introduction of food poisoning bacteria and secondary contamination by norovirus, thorough hand washing is required, and it is important that food manufacturers and cooks do not bring microorganisms and viruses into the field. Therefore, a cleaning agent for hands and fingers is required not only to have a bactericidal effect but also to have a virus inactivating effect.

As the detergent used for conventional hand cleaning, a liquid detergent composition containing a fatty acid, an amphoteric surfactant and a chelating agent and having a pH of 9.5 to 11 (Reference 1 below), alkyl. For fingers containing at least one nonionic surfactant selected from dimethylbenzylammonium salt type cationic surfactants, polyoxyalkylene alkyl ether type nonionic surfactants, alkylamine oxides, fatty acid alkanolamides and alkylpolyglucosides. Examples thereof include a sterilizing detergent composition (Reference 2 below), an alkyl glucoside, a dimethyldiallyl ammonium chloride / acrylamide copolymer, and a body detergent composition containing a surfactant other than the above two components (Reference 3 below). .. In addition, as a virus countermeasure technology, an aqueous disinfectant containing a quaternary ammonium salt type surfactant, an inorganic electrolyte and / or citrate, and an alkaline agent and having a pH of 8.1 or more and 12 or less is used as a base material. Examples thereof include a disinfectant sheet impregnated in the sheet (Reference 4).

WO2013 / 141118 Japanese Unexamined Patent Publication No. 2004-224703 JP-A-2017-190307 Japanese Unexamined Patent Publication No. 2018-27916

The cleaning agent composition described in Patent Document 1 can obtain a certain detergency because the pH is in the alkaline range, but the bactericidal effect is not sufficient and the virus inactivating effect cannot be obtained. In References 2 and 3, since the pH is in the neutral range, the detergency is not sufficient, and the virus inactivating effect cannot be obtained. The sterilization sheet of Cited Document 4 is suitably used for surface disinfection excluding the human skin surface, equipment disinfection, disinfection and virus removal of toilets and beds in medical settings, etc., but it is highly irritating to the skin and works. The person wore gloves and used the seat.

The present invention has been made in view of the above problems. That is, an object of the present invention is to provide a liquid cleaning agent composition which is excellent in detergency, bactericidal effect and virus inactivating effect and is less irritating to the skin.

As a result of diligent studies to solve the above problems, the present inventors have made a quaternary ammonium salt-type surfactant as the component (A), a pH adjuster as the component (B), and a nonionic surfactant as the component (C). At least one selected from an activator and an amphoteric surfactant is blended, a polyhydric alcohol is blended as the component (E), and the component (A) and the component (C) are further set to a specific range ratio and (A). A composition in which the ratio of the component and the component (E) is in a specific range and the pH at 25 ° C. is 8.1 or more and 12.0 or less has excellent detergency, bactericidal effect, virus inactivating effect, and on the skin. It has been found that it has hypoallergenicity, and the present invention has been completed.

That is, the liquid detergent composition for skin of the present invention contains a quaternary ammonium salt-type surfactant as the component (A), a pH adjuster as the component (B), and a nonionic surfactant as the component (C). It contains at least one selected from surfactants, water as the component (D) and polyhydric alcohol as the component (E), and the mass ratio of the components (A) and (B) is (A) / (B). ) Is 0.002 or more and 100 or less, and the mass ratio of the component (A) and the component (E) is 0.001 or more and 1 or less in the value of (A) / (E), 25 ° C. The pH in the above is 8.1 or more and 12.0 or less.

The liquid cleaning agent composition of the present invention is excellent in detergency against stains adhering to the surface to be cleaned such as skin, and is also excellent in bactericidal effect and virus inactivating effect on general bacteria and bacteria resistant to cationic surfactants. In addition, it foams well and has good rinsing properties when washing hands.
Further, the liquid cleansing composition of the present invention is less irritating to the skin even though it is alkaline. Therefore, even when it is used for fingers, the feeling of use is good, and direct use on the skin is permitted.

The liquid detergent composition of the present invention comprises a quaternary ammonium salt-type surfactant as a component (A), a pH adjuster as a component (B), a nonionic surfactant as a component (C), and an amphoteric surfactant. It contains at least one selected, water as component (D). The mass ratio of the component (A) to the component (B) is adjusted so that the value of (A) / (B) is 0.002 or more and 100 or less. Further, the liquid cleaning agent composition of the present invention has a pH of 8.1 or more and 12.0 or less at 25 ° C.

The liquid cleaning agent composition of the present invention having such a structure is excellent in detergency, bactericidal property and virus inactivation, and is less irritating to the skin. Such an effect includes the component (A) as a component excellent in bactericidal property and virus inactivation, and also contains the component (C) which is a surfactant in consideration of irritation to the skin, and the component (B). By adjusting the pH to 8.1 or more and 12.0 or less, a balance between detergency and efficacy and skin irritation was achieved, which made it possible. In the present invention, by adjusting the mass ratio of the component (A) to the component (B) within a predetermined range, the ratio of the component (A) can be appropriately suppressed, and the skin irritation can be taken into consideration while maintaining good virus resistance. Achieve activation.

The use of the liquid cleaning agent composition of the present invention is not particularly limited, and is widely used, for example, for cleaning and sterilizing meat or seafood processing sites, food-related industries such as restaurant kitchens, hospitals, and health centers. The method of use is also not particularly limited, and it is used as a cleaning agent for directly sterilizing and cleaning hands, a cleaning agent for soaking in a wiping sheet, or a cleaning agent for spray application to an object to be cleaned. be able to.

In particular, the present invention exhibits excellent cleansing properties, bactericidal properties, and virus inactivation as described above, but is less irritating to the skin, and therefore exhibits excellent effects as a cleansing agent for hands and fingers used directly on the hands and fingers. ..
The composition of the liquid cleaning agent of the present invention will be described in detail below.

The liquid cleaning agent composition of the present invention contains a quaternary ammonium salt-type surfactant as the component (A).
Quaternary ammonium salt type surfactant which is a component (A), molecular formula NR ₄ ⁺ and Cl ^- is a cationic surfactant having the structure of salts with anions such. The above-mentioned R is an arbitrary alkyl group, and the four alkyl groups (R) are not particularly limited. For example, as the component (A), dialkyldimethylammonary salt, alkyltrimethylammonium salt, alkyldimethylethylammonium salt, dialkylethylmethylammonium salt, dialkylmonomethylhydroxyammonium salt, alkyldimethylhydroxyethylammonium salt, alkyldimethylbenzylammonium salt, alkyl Examples thereof include dipolyoxyethylene methylammonium salt, alkylpyridinium salt and benzethonium salt.
Among them, as the component (A), a dialkyldimethylammonary salt, an alkyltrimethylammonium salt, an alkylpyridinium salt, an alkyldimethylbenzylammonium salt, or a benzethonium salt is preferable, and in particular, an alkyldimethylbenzylammonium salt, an alkyltrimethylammonium salt, an alkylpyridinium salt, or an alkylpyridinium salt, or Benzethonium salts are more preferred.
Furthermore, from the viewpoint of being particularly excellent in both bactericidal activity and virus inactivating effect, the alkyldimethylbenzylammonium salt is combined with at least one selected from the alkyltrimethylammonium salt, the alkylpyridinium salt and the benzethonium salt. Is particularly preferable.
The alkyl group (R) preferably has 4 or more and 22 or less carbon atoms, more preferably 6 or more and 18 or less carbon atoms, and further preferably 12 or more and 16 or less carbon atoms. The alkyl group (R) may be a straight chain or may have a branched chain. For example, the alkyl group (R) is a straight chain having 6 or more carbon atoms and 18 or less carbon atoms. Is preferable.

The component (A) contributes to the bactericidal property and virus inactivation in the liquid cleaning agent composition of the present invention. Therefore, if the amount of the component (A) is too small, the bactericidal or virus inactivating effect of the liquid cleaning agent composition may not be sufficient. On the other hand, if the amount of the component (A) is too large, the skin irritation of the liquid cleaning agent composition may become strong, and it may have an undesired effect on the rinse property and the storage stability. ..
From this point of view, the ratio of the component (A) in the liquid cleaning agent composition is preferably 0.01% by mass or more and 5.0% by mass or less, and 0.05% by mass or more and 2.0% by mass or less. Is more preferable, and 0.08% by mass or more and 1.0% by mass or less is particularly preferable. Further, from the viewpoint of suppressing skin irritation to a smaller value and providing an excellent cleaning agent for fingers in the liquid cleaning agent composition, the content of the component (E) described later is less than 0.8% by mass. Alternatively, in the case of 0.5% by mass or less, and even substantially zero, it is preferable to contain 0.4% by mass or less of the quaternary ammonium salt type surfactant as the component (A).

Here, the virus includes an enveloped virus which is a virus having an envelope and a non-enveloped virus which is a virus having no envelope.

Encapsulated viruses include human herpesvirus, vaccinia virus, influenza virus, SARS coronavirus, MERS coronavirus, SARS-CoV-2, RS virus, mumps virus, lassavirus, dengue virus, ruin virus, human immunodeficiency virus, Examples include, but are not limited to, measles virus, hepatitis B virus, hepatitis C virus, ebora virus, yellow fever virus, and Japanese encephalitis virus.

Non-enveloped viruses include norovirus, poliovirus, echovirus, rhinovirus, astrovirus, rotavirus, coxsackie virus, enterovirus, sapovirus, adenovirus, B19 virus, papovavirus, human papillomavirus, hepatitis A virus, and Examples include, but are not limited to, hepatitis E virus.

The liquid cleansing composition of the present invention exhibits good bactericidal properties and virus inactivating effects while adjusting the blending amount of the component (A) to an appropriate range and suppressing skin irritation to a small level. The composition of the component (A) may be determined by adjusting the mass ratio of the component (A) and the component (B) within a predetermined range together with the compounding amount (mass%) of the component (A).

The component (B) is a pH adjuster for adjusting the pH of the liquid cleaning agent composition of the present invention. The liquid cleaning agent composition of the present invention has a pH adjusted in the range of 8.1 or more and 12.0 or less depending on the component (B) while considering the blending amount of other compositions. A general alkaline cleanser is highly irritating to the skin and avoids direct use on the fingers. However, the present invention is alkaline, but due to the combination of the components (A) and (C), It is possible to exert high detergency, bactericidal activity and virus inactivating effect (hereinafter, these are also referred to as detergency and the like) while suppressing irritation to the skin.

The pH is preferably 9 or more, more preferably 9.5 or more, from the viewpoint of exerting more sufficient bactericidal activity against detergency cation-resistant bacteria. Further, the pH is preferably 11.5 or less, more preferably 11 or less, and particularly preferably less than 11, from the viewpoint of providing a cleaning agent having less skin irritation.

The pH adjuster can be selected from compounds that can adjust the pH of the liquid cleaning agent composition without departing from the spirit of the present invention. For example, the pH regulator may include any one or combination selected from alkali metal hydroxides, alkali metal silicates, alkanolamines, alkali metal carbonates, alkali metal phosphates, and organic acid salts. ..
Examples of the alkali metal hydroxide include sodium hydroxide, potassium hydroxide and the like.
Examples of the alkali metal silicate include sodium orthosilicate, potassium orthosilicate, sodium metasilicate, potassium metasilicate, sodium No. 1 silicate, sodium No. 2 silicate, sodium No. 3 silicate, potassium A silicate, potassium B silicate, or C silicate. Examples include potassium.
Examples of the alkanolamine include monoethanolamine, diethanolamine, triethanolamine and the like.
Examples of the alkali metal carbonate include sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, sodium sesquicarbonate, potassium sesquicarbonate, sodium percarbonate, potassium percarbonate and the like.
Examples of the alkali metal phosphate include sodium phosphate, potassium phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate and the like.
Examples of the organic acid salt include sodium citrate, potassium citrate, trisodium citrate, trisodium citrate, sodium gluconate, potassium gluconate, sodium lactate, potassium lactate, sodium acetate, potassium acetate and the like.

From the viewpoint of detergency, alkali metal hydroxide or alkanolamine is preferably used as the component (B).
Also, from the viewpoint of good virus inactivation for the object to be cleaned to which organic stains have been added, it is selected from alkali metal hydroxide and / or alkanolamine, alkali metal carbonate, alkali metal phosphate, and organic acid salt. It is preferable to use in combination with at least one of the above. It is presumed that the buffering action of carbonate, phosphate or organic acid salt suppresses the decrease in pH even when dirt is added, and exerts an excellent virus inactivating effect.

The content of the pH adjuster as the component (B) can be appropriately determined within a range in which the pH of the liquid cleaning agent composition can be adjusted to a desired value. From the viewpoint of exhibiting good detergency, no problem of skin irritation even when used directly on fingers, and maintaining storage stability of the liquid detergency composition, the detergency composition of component (B) The proportion in the medium is preferably 0.05% by mass or more and 5.0% by mass or less, more preferably 0.1% by mass or more and 3.0% by mass or less, and 0.3% by mass or more and 2. It is particularly preferably 5% by mass or less.

By the way, when a general liquid cleaning agent composition is brought into contact with an object to be cleaned having stains such as organic substances, the pH of the liquid cleaning agent composition may be significantly lowered. As a result, the detergency and the like are deteriorated, and the object to be cleaned is not sufficiently cleaned and sterilized. Further, there is a problem that sufficient sterilization is not performed even if a disinfectant solution or the like is sprayed on the object to be cleaned that has not been completely cleaned and sterilized.
On the other hand, in the liquid cleaning agent composition of the present invention, the pH is adjusted to a predetermined range by the pH adjusting agent which is the component (B), so that the liquid cleaning composition maintains alkalinity even when it comes into contact with organic stains. As a result, high detergency and the like are easily maintained.
Weak bases such as sodium hydrogen carbonate, potassium hydrogen carbonate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, trisodium citrate, and tripotassium citrate have a buffering effect. Even when it comes into contact with stains, it is possible to suppress a decrease in pH of the liquid cleaning agent composition and maintain high detergency, etc., and to improve the virus inactivating effect on the object to be cleaned to which organic stains are attached. It can be demonstrated.

In the present invention, the mass ratio of the component (A) to the component (B) described above is adjusted so that the value of (A) / (B) is 0.002 or more and 100 or less. By adjusting to such a range, the liquid cleansing composition of the present invention can exhibit good cleansing property, bactericidal property and virus inactivating effect while suppressing skin irritation.
From the viewpoint of exerting higher bactericidal activity and virus inactivating effect while suppressing skin irritation, the lower limit of (A) / (B) is preferably 0.01 or more, preferably 0.05. The above is more preferable. Further, from the viewpoint of exhibiting higher detergency while suppressing skin irritation, the upper limit of the above (A) / (B) is preferably 10.0 or less, and preferably 1.0 or less. More preferably, it is more preferably 0.6 or less.

The liquid cleaning agent composition of the present invention contains at least one selected from nonionic surfactants and amphoteric surfactants as the component (C). These surfactants contribute to achieving good cleansing properties while suppressing irritation to the skin, and also contribute to good foaming of the liquid cleansing composition.

Examples of the nonionic surfactant as the component (C) include aliphatic alkanolamide, polyoxyalkylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene polyoxypropylene glycol, sucrose fatty acid ester, and monoglycerin fatty acid ester. Examples thereof include polyglycerin fatty acid ester, sorbitan fatty acid ester, alkylene oxide adduct of sorbitan fatty acid ester, and alkyl glucoside.
The number of carbon atoms of the alkyl group is not particularly limited, but is preferably 6 or more and 14 or less, and more specific examples thereof include octyl glucoside, decyl glucoside, and lauryl glucoside.

Examples of the amphoteric tenside as the component (C) include betaine-type amphoteric tenside, amino acid-type amphoteric tenside, and amine oxide-type amphoteric tenside.

With respect to the present invention, the betaine-type amphoteric surfactant refers to a surfactant having betaine in its molecular structure and thereby exhibiting amphipathic properties. Here, betaine refers to an intramolecular salt having a positive charge and a negative charge at non-adjacent positions in the same molecule.
The betaine-type amphoteric tenside agent includes an alkylbetaine-type amphoteric tenside agent, an alkylimidazolinium betaine-type amphoteric tenside agent, a fatty acid amide propyl betaine-type amphoteric tenside agent, and a glycine-type amphoteric tenside agent.

Examples of the above-mentioned alkyl betaine type amphoteric surfactant include alkyl carbobetaine, alkyl sulfobetaine, alkyl hydroxy sulfo betaine, alkyl amide carbobetaine, alkyl amide sulfo betaine, alkyl amide hydroxy sulfo betaine, alkyl dimethyl betaine, and alkyl diethyl betaine. Examples thereof include alkylhydroxyethyl betaine and alkylamide propyldimethylaminoacetic acid betaine. The number of carbon atoms of the alkyl group is not particularly limited, but is preferably 8 or more and 18 or less, and more specific examples thereof include lauryldihydroxyethyl betaine and laurylamide propyldimethylaminoacetate betaine.
Examples of the alkylimidazolinium betaine-type amphoteric surfactant include 2-alkyl-N-carboxyethyl-N-hydroxyethyl imidazolinium betaine. The number of carbon atoms of the alkyl group is not particularly limited, but is preferably 8 or more and 18 or less.
Examples of the fatty acid amide propyl betaine type amphoteric surfactant include coconut oil fatty acid amide propyl betaine, palm oil fatty acid amide propyl betaine, lauric acid amide propyl betaine, and ricinoleic acid amide propyl betaine.
Examples of the glycine-type amphoteric tenside include alkylaminoethyl glycine, alkyldiaminoethylglycine, dialkyldiaminoethylglycine and the like. The number of carbon atoms of the alkyl group is not particularly limited, but is preferably 8 or more and 16 or less.

Examples of the amino acid amphoteric tenside agent according to the present invention include aminopropionic acid amphoteric acid surfactants such as alkylaminopropionic acid and alkylaminodipropionic acid. The number of carbon atoms of the alkyl group is not particularly limited, but is preferably 8 or more and 18 or less, and more specific examples thereof include sodium laurylaminodipropionate and sodium oleylaminodipropionate.

Regarding the present invention, examples of the amine oxide type amphoteric surfactant include alkyldimethylamine oxide and the like.

From the viewpoint of providing a liquid cleaning agent composition exhibiting more preferable foam retention and rinsing property, the components (C) described above include polyoxyalkylene alkyl ethers such as polyoxyethylene alkyl ethers, alkyl glucosides, and alkyl betaines. It is preferable to contain at least one selected from an amphoteric tenside agent, an alkylimidazolinium betaine amphoteric tenside agent, an aminopropionic acid amphoteric tenside agent, and an alkyldimethylamine oxide. More preferably, it contains at least one of an alkyl glucoside containing an alkyl polyglucoside, an alkyl betaine type amphoteric tenside, and an alkyl imidazolinium betaine type amphoteric tenside.
Further, from the viewpoint of virus inactivating effect, it is preferable to contain at least one of an alkyl glucoside containing an alkyl polyglucoside and an alkyl dimethyl amine oxide as the component (C).

The content of the nonionic surfactant or amphoteric surfactant as the component (C) can be appropriately determined within a range that does not deviate from the gist of the present invention. From the viewpoint of providing a liquid cleaning composition having good foaming, the ratio of the component (C) in the cleaning composition is preferably 0.1% by mass or more, preferably 0.3% by mass or more. It is more preferable to have it, and it is particularly preferable that it is 0.8% by mass or more.
Further, from the viewpoint of providing a liquid cleaning agent composition having excellent storage stability and better rinsing property, the ratio of the component (C) in the cleaning agent composition is 8.0% by mass or less. Is more preferable, 5.0% by mass or less is more preferable, and 4.0% by mass or less is particularly preferable.

The liquid cleaning agent composition of the present invention contains water as the component (D). The water of the component (D) is not particularly limited, and examples thereof include ion-exchanged water, soft water, pure water, and tap water.

The liquid cleaning agent composition of the present invention may contain a polyhydric alcohol as the component (E) in addition to the above components (A), (B), (C) and (D). By including the component (E), it is possible to further reduce the skin irritation of the liquid cleansing composition. For example, in order to exhibit higher detergency, even when a relatively large amount of the component (A) is blended or the pH is adjusted to be high within a predetermined range, the component (E) is contained. , Skin irritation can be suppressed.
Examples of the component (E) include ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,4-butanediol, 1, Examples thereof include 5-pentanediol, hexylene glycol, glycerin, polyglycerin, sorbitol, etc. Among them, ethylene glycol, polyethylene glycol, propylene glycol, butylene glycol, 1,5-pentanediol, hexylene glycol, glycerin, sorbitol and the like. Preferred, especially glycerin.

When the component (E) is blended, the blending amount of the component (E) can be appropriately determined in consideration of the blending of each component of the liquid cleaning agent composition. From the viewpoint of more reliably exerting the effect of suppressing skin irritation, the ratio of the component (E) in the liquid cleansing composition is preferably 0.1% by mass or more, preferably 0.5% by mass or more. Is more preferable, and 1% by mass or more is particularly preferable. When the component (E) is blended in an amount of 1% by mass or more, even when the component (A) is blended in an amount of more than 0.4% by mass and further in an amount of 0.7% by mass or more. The effect of skin irritation caused by the component (A) can be mitigated.
Further, when the degree of the effect of lowering the skin irritation with respect to the blending amount of the component (E) is taken into consideration, the ratio of the component (E) in the cleaning agent composition is when it is blended in an amount of more than 15.0% by mass. Even if there is, there is no change in the degree of skin irritation lowering effect, and 10.0% by mass or less can sufficiently exert the skin irritation lowering effect, and considering cost performance, it is 7.0% by mass or less. It is preferable to do so.

From the viewpoint of suppressing skin irritation while exhibiting good bactericidal properties and virus inactivating effects, it is preferable to adjust the mass ratio of the components (A) and (E). Specifically, from the viewpoint of exerting more preferable detergency, bactericidal property, or virus inactivating effect, the mass ratio of the component (A) to the component (E) is the value of (A) / (E). It is preferably 0.001 or more, more preferably 0.005 or more, and further preferably 0.02 or more. Further, from the viewpoint of sufficiently reducing skin irritation and maintaining good storage stability, the above (A) / (E) is preferably 50 or less, and preferably 10 or less. It is more preferably 1 or less.

The liquid cleaning composition of the present invention may contain other components usually used in the art, if necessary, as long as the effects of the present invention are not impaired. Such components include, for example, capric acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, coconut fatty acid or fatty acids such as salts thereof, benzotriazole, triltriazole, benzo. Metal corrosion inhibitors such as thiazole, 1-hydroxyethylidene-1,1-diphosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, aminotrimethylenephosphonic acid, alcoholic solvents such as ethanol, isopropanol and phenoxyethanol, Glycol ether-based solvents such as diethylene glycol monobutyl ether and dipropylene glycol monobutyl ether, chelating agents such as ethylenediamine tetraacetic acid, diethylenetriaminopentacetic acid, triethylenetetraaminehexacetic acid, methylglycine diacetic acid, glutamate diacetic acid or salts thereof, isopropyl Examples thereof include bactericides such as methylphenol, triclosan and triclocarban, thickeners such as xanthan gum, inorganic electrolytes such as sodium chloride, fragrances and pigments. Of the above components, fatty acids are easy to hold bubbles, alcohol solvents are bactericidal, glycol ether solvents are storage stability, and thickeners and inorganic electrolytes are foamy. It may be preferably blended. When the alcohol solvent is contained in the liquid cleaning agent composition from the viewpoint of improving the bactericidal property while suppressing the skin irritation, the alcohol solvent is, for example, 0.01% by mass or more and 1.0% by mass or less. It is preferable that it is contained in the range of 0.05% by mass or more and 0.8% by mass or less, and it is more preferable that it is contained in the range of 0.1% by mass or more and 0.6% by mass or less. More preferred.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples. Tables 1 to 8 below show each component used in the formulation in the liquid cleaning agent compositions of Examples and Comparative Examples. The numerical values relating to the blending amounts shown in Tables 1 to 8 below are the ratio (mass%) of the pure content of each component to the liquid cleaning agent composition.
Further, the liquid cleaning agent compositions of each Example and each Comparative Example were measured for pH at 25 ° C. and various evaluations described later were performed. The results are shown in Tables 1-8.

(A) Component A-1: Alkyl (C12-16) Dimethylbenzylammonium chloride A-2: Benzethonium chloride A-3: Hexadecyltrimethylammonium chloride A-4: Alkyl (C16-18) trimethylammonium chloride A-5: Cetylpyridinium chloride A-1 which is the component (A) is a mixture of alkyldimethylammonium chloride having an alkyl group having 12 to 16 carbon atoms, and A-4 has an alkyl group having 16 to 18 carbon atoms. It is a mixture of alkyltrimethylammonium chloride having.

(B) Component B-1: Potassium hydroxide B-2: Monoethanolamine B-3: Sodium hydrogen carbonate B-4: Disodium hydrogen phosphate B-5: Trisodium citrate B-6: Sodium carbonate B- 7: Sodium dihydrogen phosphate

(C) Component C-1: Lauryl glucoside C-2: Lauryl amidopropyl dimethylaminoacetic acid betaine C-3: Sodium lauryl aminodipropionate C-4: 2-alkyl-N-carboxyethyl-N-hydroxyethyl imidazole Niumbetaine C-5: Polyoxyethylene alkyl ether (has a linear hydrocarbon group having 12 carbon atoms, and the average number of added moles of the oxyethylene group is 7).
C-6: Lauryl dimethylamine oxide

(D) Component D-1: Ion-exchanged water

(E) Ingredient E-1: Glycerin
E-2: Propylene glycol E-3: Polyethylene glycol (weight average molecular weight 400)

Other components F-1: Ethylenediaminetetraacetic acid disodium F-2: Sodium chloride F-3: Ethanol F-4: Phenoxyethanol

* 1: Detergency test <Test method>
This test is conducted once a day after work for 10 panelists who perform office work and on-site work using a wiping test tool (Lucipac (registered trademark) PEN; manufactured by Kikkoman Co., Ltd.) in accordance with the instruction manual. went. The test used a kind of liquid cleaning composition per day.
First, the cotton swab set in the main body of the Lucipack PEN was pulled out, and both hands of each panelist were wiped with the cotton swab before hand washing, and this was used as a wiping sample. The wiped sample was returned to the Lucipack PEN main body and sufficiently immersed in a luminescent reagent in a measuring tube provided at the tip of the Lucipack PEN. After that, using a luminescence amount measuring device (Lumitester (registered trademark) PD-30; manufactured by Kikkoman Co., Ltd.), Lucipack PEN was inserted into the measurement chamber of the luminester PD-30, and the ATP luminescence amount (RLU _{0) before hand washing was performed.} ) Was measured.
After preparing the wiping sample, each panelist picked up 1 mL of the liquid cleaning agent composition, hand-washed for 30 seconds, rinsed with tap water for 30 seconds, drained sufficiently, and finished hand-washing.
Then, after hand-washing, the amount of ATP emission (RLU ₁ ) after hand-washing of each panelist was measured by the same method as described above. Using the measured values of ATP luminescence before hand washing (RLU ₀ ) and ATP luminescence after hand washing (RLU ₁ ), the washing rate by hand washing was calculated by the following (Equation 1), and the average value of the washing rates of 10 panelists. Was determined, and the detergency was evaluated according to the evaluation criteria described later.
(Equation 1)
Cleaning rate (%) = 100-RLU ₁ / RLU ₀ x 100 ... (1)

<Evaluation criteria>
⊚: Cleaning rate is 90% or more.
◯: The cleaning rate is 75% or more and less than 90%.
Δ: The cleaning rate is 60% or more and less than 75%.
X: The cleaning rate is less than 60.
, Δ, ○, and ◎ were judged to be practical.

* 2: Bactericidal activity test against general bacteria <Test bacteria>
Escherichia coli (Escherichia coli NBRC3972) and Staphylococcus aureus NBRC12732 (Staphylococcus aureus NBRC12732) were used as test bacteria. Each test bacterium was smeared on SCD agar medium (manufactured by Eiken Chemical Co., Ltd.), cultured at 37 ° C. for 24 hours, the colonies were scraped off, and each diluted in sterile phosphate buffered saline was used as a bacterial suspension. Used as.

<Test method>
Each liquid detergent composition 10 mL, was added the cell suspension 0.1mL to a final concentration of ^{1.5~5.0 × 10 8 (CFU / mL} ), is contacted for 15 seconds at 25 ° C. After that, a sterilized neutralizing solution (SCDLP medium, manufactured by Eiken Kagaku Co., Ltd.) was added and stirred well to prepare a test solution. After mixing and solidifying 1 mL of this test solution on SCD agar medium, the cells were cultured at 37 ° C. for 2 days. After culturing, the viable cell count was measured, the log reduction value was determined from the difference from the initial bacterial count, and the bactericidal activity was evaluated according to the following criteria.

<Evaluation criteria>
⊚: The logarithmic reduction value of the test bacterium is 5 or more.
◯: The logarithmic reduction value of the test bacteria is 3 or more and less than 5.
Δ: The logarithmic reduction value of the test bacteria is 1 or more and less than 3.
X: The logarithmic reduction value of the test bacteria is less than 1.
, Δ, ○, and ◎ were judged to be practical.

* 3: Bactericidal activity test against cation-resistant bacteria <test bacteria>
As a test bacterium, Serratia marcescens (a field isolate) showing resistance to a cationic surfactant was used. Serratia marcescens is smeared on SCD agar medium containing a cationic surfactant, cultured at 30 ° C. for 24 hours, then the colonies are scraped off and diluted in sterile phosphate buffered saline is used as a bacterial suspension. Used as.

<Test method>
Yeast extract in the liquid detergent composition 10mL containing 0.1 wt% as soil, final concentration ^{1.5~5.0 × 10 8 (CFU / mL} ) and made as described above cell suspension 0.1mL Was added, and the mixture was contacted at 25 ° C. for 1 minute, then a sterilized neutralizing solution (SCDLP medium: manufactured by Eiken Kagaku Co., Ltd.) was added and stirred well to prepare a test solution. After mixing and solidifying 1 mL of this test solution on SCD agar medium, the cells were cultured at 30 ° C. for 2 days. After culturing, the viable cell count was measured, the log reduction value was determined from the difference from the initial bacterial count, and the bactericidal activity was evaluated according to the following criteria.

<Evaluation criteria>
⊚: The logarithmic reduction value of the test bacterium is 5 or more.
◯: The logarithmic reduction value of the test bacteria is 3 or more and less than 5.
Δ: The logarithmic reduction value of the test bacteria is 1 or more and less than 3.
X: The logarithmic reduction value of the test bacteria is less than 1.
, Δ, ○, and ◎ were judged to be practical.

* 4: Feline calicivirus inactivation test <test method>
To a test tube, add 0.9 mL of each liquid cleaning agent composition and ^{0.1 mL of feline calicivirus solution (FCV F9 strain) adjusted to 10 8} TCID ₅₀ / mL, and add virus test solution (virus test solution 1). ) Was prepared, mixed with a mixer, and allowed to act at 25 ° C. for 30 seconds.
Further, assuming organic stains, and the liquid detergent composition of 0.9mL in a test ^tube, 10 _{8 TCID} 50 / mL become so adjusted 0.5% meat extract (manufactured by Nacalai Tesque) containing Nekokarishi 0.1 mL of virus solution (FCV F9 strain) was added to prepare an organic stain-containing virus test solution (virus test solution 2), mixed with a mixer, and allowed to act at 25 ° C. for 30 seconds.
Then, after reacting for 30 seconds as described above, the virus test solutions 1 and 2 were diluted 7-fold with Dulvecco's modified Eagle's Medium (DMEM) supplemented with 2% fetal bovine serum (FBS), and the reaction was stopped. I let you. The stop solution in which the reaction was stopped was diluted 7-fold with DMEM medium, and each diluted solution was inoculated into cat kidney cells (CRFK) and cultured in DMEM medium supplemented with 1% FBS at 37 ° C. in a CO ₂ incubator for 4 days. .. After culturing, the cytopathic effect was observed, and the virus infectivity titer (TCID ₅₀ / mL) was determined. The virus infectivity logarithm reduction value (virus infection value) was calculated from the initial infection titer of the control and the infectious titer after the action of the test product, and the virus inactivating effect was evaluated according to the following criteria.

<Evaluation criteria>
⊚: The logarithmic reduction value of the virus infection titer decreased by 4 or more.
◯: Decrease in logarithmic reduction of virus infection titer of 3 or more and less than 4.
Δ: A decrease in the logarithmic reduction value of the virus infection titer of 2 or more and less than 3.
X: Decrease in logarithmic reduction of virus infection titer by less than 2.
, Δ, ○, and ◎ were judged to be practical.

* 5: Foam retention test <Test method>
In this test, each liquid cleaning agent composition was foamed at 25 ° C. by the Ross Miles method (JIS K 3362), and the foam height was measured at the start of measurement and 5 minutes later. From the measurement starting foam height after 5 minutes of foam height for (F ₀₎ (F _1), to calculate the bubble retention by the following (Equation 2) to evaluate the foam retention on the following criteria. A commercially available foam pump was used for foaming the liquid cleaning agent composition.
(Equation 2)
Foam retention rate (%) = F ₁ / F ₀ x 100 ... (2)

<Evaluation criteria>
〇: Foam retention rate is 90% or more.
Δ: Foam retention rate is 80% or more and less than 90%.
X: The foam retention rate is less than 80%, or sufficient foaming cannot be obtained.
And, Δ and ○ were judged to be practical.

* 6: Rinseability test <Test method>
The study was conducted on 10 panelists who were trained in assessing rinseability. Take 1 push (about 1 mL) of each liquid cleaning agent composition in a commercially available foam pump in each panelist's hand, wash by hand for 30 seconds, then rinse with tap water for 30 seconds, speed of rinsing, after rinsing Rinability was evaluated according to the following criteria based on the lack of tension in the hands.

<Evaluation criteria>
4 points: Good rinsing property 3 points: Slightly good rinsing property 2 points: Slightly poor rinsing property 1 point: Evaluate the rinsing property with a score and calculate the average value, and use the following criteria for rinsing property evaluated.
⊚: The average value is 3.4 points or more.
〇: The average value is 2.7 points or more and less than 3.4 points.
Δ: The average value is 2.0 points or more and less than 2.7 points.
X: The average value is less than 2.0 points.
, Δ, ○, and ◎ were judged to be practical.

* 7: Skin irritation test <test method>
This test was conducted on 10 panelists per example. The panelists of this test did not perform the detergency test, rinse property test and skin irritation test of the liquid cleaning agent composition described in other examples during this test. Take 1 mL of the liquid cleaning agent composition in each panelist's hand, wash the hand for 30 seconds, then rinse with tap water for 30 seconds. Repeat the hand wash operation 3 times a day for 7 days, and after 7 days, each panelist's hand. Skin irritation was evaluated based on the following criteria.

<Evaluation criteria>
4 points: No rough hands 3 points: Slightly rough hands 2 points: Rough hands are seen in some places 1 point: Rinseability is evaluated by points and the average value is calculated based on the following criteria. The overkill was evaluated.
⊚: The average value is 3.5 points or more.
〇: The average value is 3.0 points or more and less than 3.5 points.
Δ: The average value is 2.5 points or more and less than 3.0 points.
X: The average value is less than 2.5 points.
, Δ, ○, and ◎ were judged to be practical.

* 8: Storage stability test <Test method>

200 ml of each liquid cleaning agent composition was placed in a 250 ml transparent polypropylene container, covered, and stored in a constant temperature bath at −5 ° C., 25 ° C., and 40 ° C. and allowed to stand. One month later, the appearance was observed and the storage stability was evaluated according to the following criteria.

<Evaluation criteria>
◯: Stable with no precipitates or turbidity.
Δ: Some precipitates and turbidity are observed.
X: Precipitates or turbidity are observed.
And, Δ and ○ were judged to be practical.

* 9: Bactericidal activity test against methicillin-resistant Staphylococcus aureus (MRSA) <Test bacteria>
As a test bacterium, methicillin-resistant Staphylococcus aureus ATCC43330 was used. Each test bacterium was smeared on SCD agar medium (manufactured by Eiken Chemical Co., Ltd.), cultured at 37 ° C. for 24 hours, the colonies were scraped off, and each diluted in sterile phosphate buffered saline was used as a bacterial suspension. Used as.

<Test method>
Each liquid detergent composition 10 mL, was added the cell suspension 0.1mL to a final concentration of ^{1.5~5.0 × 10 8 (CFU / mL} ), is contacted for 15 seconds at 25 ° C. After that, a sterilized neutralizing solution (SCDLP medium, manufactured by Eiken Kagaku Co., Ltd.) was added and stirred well to prepare a test solution. After mixing and solidifying 1 mL of this test solution on SCD agar medium, the cells were cultured at 37 ° C. for 2 days. After culturing, the viable cell count was measured, the log reduction value was determined from the difference from the initial bacterial count, and the bactericidal activity was evaluated according to the following criteria.

<Evaluation criteria>
⊚: The logarithmic reduction value of the test bacterium is 5 or more.
◯: The logarithmic reduction value of the test bacteria is 3 or more and less than 5.
Δ: The logarithmic reduction value of the test bacteria is 1 or more and less than 3.
X: The logarithmic reduction value of the test bacteria is less than 1.
, Δ, ○, and ◎ were judged to be practical.

* 10: Influenza virus inactivation test <test method>
Virus test by adding 0.9 mL of each liquid cleaning agent composition and 0.1 mL of influenza virus solution (Influenza A virus (H3N2) ATCC VR-1679) adjusted to ^{10 8} TCID _{50 / mL to a test tube.} A solution (virus test solution 1) was prepared, mixed with a mixer, and allowed to act at 25 ° C. for 30 seconds. After action, 0.1 mL of virus test solution was collected and added to 9.9 mL of action arrest solution (cell growth solution containing 2% sodium thiosulfate, 0.2% lecithin and 1.5% polysorbate 80) 100 times. After dilution, the reaction to the virus was stopped. This was used as a sample stock solution for measuring virus infectious titer in measuring infectious titer. Similarly, a test using phosphate buffered saline (hereinafter, may be abbreviated as PBS) was carried out and used as a control. Phosphate buffered saline is a mixture of 8 g of sodium chloride, 0.2 g of potassium chloride, 1.44 g of disodium hydrogen phosphate, and 0.24 g of potassium dihydrogen phosphate, and is made into 900 mL with ultrapure water. After dissolution, the pH was adjusted to 7.4 with hydrochloric acid, the pH was adjusted to 1 L, and the mixture was sterilized by autoclave.
After diluting the sample stock solution for virus infectious titer 10-fold with PBS, 50 μL of the sample stock solution for infectious titer measurement and diluted virus solution and 5% of bovine fetal serum (FBS) were added to Dulvecco's modified Eagle's Medium (DMEM). ) Was implanted in a 96-well plate. Then, the cells were cultured in a carbon dioxide incubator at 37 ° C. and 5% CO ₂ for 4 days. After culturing, the cytopathic effect was observed, and the virus infectivity titer (TCID ₅₀ / mL) was determined. The virus infectivity logarithm reduction value (virus infection value) was calculated from the initial infection titer of the control and the infectious titer after the action of the test product, and the virus inactivating effect was evaluated according to the following criteria.

<Evaluation criteria>
⊚: The logarithmic reduction value of the virus infection titer decreased by 4 or more.
◯: Decrease in logarithmic reduction of virus infection titer of 3 or more and less than 4.
Δ: A decrease in the logarithmic reduction value of the virus infection titer of 2 or more and less than 3.
X: Decrease in logarithmic reduction of virus infection titer by less than 2.
, Δ, ○, and ◎ were judged to be practical.

The above embodiment includes the following technical ideas.
(1) A quaternary ammonium salt-type surfactant as a component (A),
(B) As a component, a pH adjuster,
(C) At least one selected from nonionic surfactants and amphoteric surfactants as components,
(D) Water as an ingredient
The mass ratio of the component (A) to the component (B) is 0.002 or more and 100 or less as the value of (A) / (B), and the pH at 25 ° C. is 8.1 or more and 12. A liquid cleaning agent composition characterized by being 0 or less.
(2) The above (1), wherein the component (A) contains an alkyldimethylbenzylammonium salt and at least one selected from an alkyltrimethylammonium salt, an alkylpyridinium salt, and a benzethonium salt. Liquid cleaning agent composition.
(3) The components (C) are polyoxyalkylene alkyl ether, alkyl glucoside containing alkyl polyglucoside, alkyl betaine type amphoteric tenside, alkyl imidazolinium betaine type amphoteric tenside, aminopropionic acid amphoteric tenside. , The liquid cleaning agent composition according to (1) or (2) above, which contains at least one selected from alkyldimethylamine oxide.
(4) The liquid cleaning agent composition according to (3) above, which contains at least one of the above alkyl glucoside and the above alkyl dimethylamine oxide as the component (C).
(5) The liquid cleaning agent composition according to any one of (1) to (4) above, which further contains a polyhydric alcohol as a component (E).
(6) The liquid cleaning according to (5) above, wherein the mass ratio of the component (A) to the component (E) is 0.001 or more and 50 or less as the value of (A) / (E). Agent composition.
(7) The liquid cleaning agent composition according to any one of (1) to (6) above, wherein the pH of the composition at 25 ° C. is 8.1 or more and less than 11.
(8) The liquid cleansing composition according to any one of (1) to (7) above, wherein the cleansing composition is a liquid cleansing agent for skin.
(9) The liquid cleaning agent composition according to any one of (1) to (8) above, wherein the cleaning agent composition contains an alcohol solvent.

Claims (9)

(A) As a component, a quaternary ammonium salt-type surfactant,
(B) As a component, a pH adjuster,
(C) At least one selected from nonionic surfactants and amphoteric surfactants as components,
(D) Water as an ingredient
(E) Polyhydric alcohol as an ingredient,
The mass ratio of the component (A) to the component (B) is 0.002 or more and 100 or less in the value of (A) / (B), and the mass ratio of the component (A) and the component (E) is 100 or less. but, (a) / (E) value 0.001 or more, is 1 or less, pH 8.1 or more at 25 ° C., skin liquid detergent composition characterized in that at 12.0 .. The skin liquid according to claim 1, wherein the component (A) contains an alkyldimethylbenzylammonium salt and at least one selected from an alkyltrimethylammonium salt, an alkylpyridinium salt, and a benzethonium salt. Cleaning agent composition. The component (C) is polyoxyalkylene alkyl ether, alkyl glucoside containing alkyl polyglucoside, alkyl betaine type amphoteric tenside, alkyl imidazolinium betaine type amphoteric tenside, aminopropionic acid amphoteric tenside, alkyl dimethyl. The liquid cleaning agent composition for skin according to claim 1 or 2, which contains at least one selected from amine oxides. The liquid cleansing composition for skin according to claim 3, which contains at least one of the alkyl glucoside and the alkyl dimethylamine oxide as the component (C). According to any one of claims 1 to 4, which contains at least any one of ethylene glycol, polyethylene glycol, propylene glycol, butylene glycol, 1,5-pentanediol, hexylene glycol, glycerin, and sorbitol as the component (E). The liquid cleaning agent composition for skin according to the above. In the liquid cleansing composition for skin, the component (A) is contained in the range of 0.08% by mass or more and 1.0% by mass or less, and the component (E) is 0.1% by mass or more and 10.0% by mass or more. The liquid cleansing composition for skin according to any one of claims 1 to 5, which is contained in a range of% or less. The liquid cleansing composition for skin according to any one of claims 1 to 6, wherein the pH of the composition at 25 ° C. is 8.1 or more and less than 11. The liquid cleaning agent composition according to any one of claims 1 to 7, wherein the cleaning agent composition is a liquid cleaning agent for fingers. The liquid cleansing composition for skin according to any one of claims 1 to 8, wherein the cleansing composition contains an alcohol solvent.