JP6792104B2 - Chemical injection device - Google Patents

Description

The present invention is an injection chemical injection device having a purging function of removing air from a container and a tube prior to injection of the chemical in a chemical injection device for injecting a chemical solution filled in a container such as a syringe via a tube. Regarding.

Currently, CT (Computed Tomography) scanners, MRI (Magnetic Resonance Imaging) devices, PET (Positron Emission Tomography) devices, ultrasonic diagnostic devices, angiography devices (angiography) and the like are known as diagnostic imaging devices for medical use. There is. When using such an imaging device, a drug solution such as a contrast medium or physiological saline may be injected into the patient using the drug solution injection device.

In particular, in recent years, in angiography technology using a drug solution injection device, due to the development of X-ray equipment, catheters, contrast media, etc., treatment techniques (IVR: Interventional Radiology) using an image diagnostic device can be used instead of only conventional diagnostic imaging. ) Has evolved. When considered by procedure, it can be divided into local injection (arterial injection) of drug solution using a catheter, embolization of blood vessels, dilation and opening of blood vessels. Targets include tumors, bleeding, and vascular lesions. For tumors, there are intraarterial infusion of anticancer drugs and diameter catheter-based arterial embolization (TAE: Transcatheter Artery Embolization). For bleeding, there are continuous intraarterial injection of vasoconstrictors and arterial embolization, and for vascular lesions, there are thrombolysis and percutaneous angioplasty (PTA: Percutaneous Transluminal Angioplasty).

Among the percutaneous angioplasties that are currently being actively performed, percutaneous transluminal coronary angioplasty (PTCA: Percutaneous Transluminal Colonary Angioplasty) is rapidly developing, and PTCA is a balloon catheter and atelectomy (PTCA). It can be roughly divided into coronary porridge resection) and stent implantation. Against the background of such evolution of angiography, various blood vessels directly connected to organs and lesions in the head, chest (including heart), abdomen, and lower limbs are selectively or the same blood vessels are imaged repeatedly (complex). To confirm the running of blood vessels, change the imaging angle to know the anterior-posterior relationship of blood vessels, fine-tune the injection conditions that prevent the catheter from coming off, and make sure that the treatment is connected at the same time as the image diagnosis (for confirmation after treatment). Is required.

Further, against such a background, an angiography apparatus capable of acquiring a tomographic image similar to that of a CT apparatus has been put into practical use. As a result, even if a CT tomography image is required during the examination by the angiography device, the desired image can be captured only by the angiography device. The number of combined tests and treatments is expected to increase in the future.

As described above, in the examination using the angiography device, the concentration and injection speed of the contrast medium are adjusted appropriately according to the blood vessel site, and the contrast medium is repeatedly injected. This is one of the differences from the CT and MR examinations that are performed.

For example, Patent Document 1 discloses an example of a drug solution injection device for angiography. This drug solution injection device is used, for example, for angiography by a catheter method. In the catheterization method, the catheter is percutaneously introduced into a blood vessel (artery) by a guide wire without incising the skin. Then, after locating the tip of the catheter near the origin of the target blood vessel, the drug solution injection device is operated to inject the contrast medium according to a predetermined injection protocol, and continuous imaging is performed using the imaging device. As a result, an image showing the contrast-enhanced blood vessel is displayed on a predetermined display, and the doctor makes a diagnosis and treatment while looking at the image.

As a drug solution injection device for angiography, for example, as disclosed in Patent Document 1, a device including an injection head and a console is known. The injection head for angiography has the following features, which are different from the injection head for CT examination and MR examination. That is, in angiography, since the drug solution is injected through an elongated catheter introduced into the blood vessel, the injection pressure is very high. Therefore, in many cases, the syringe is mounted on the injection head in a state of being put in a protective cover or the like. This is different from the injection heads for CT and MR examinations, where the syringe is mounted directly or via an adapter that holds a portion of the syringe.

By the way, when injecting a drug solution using a drug solution injection device, an extension tube is connected to the syringe, and a catheter introduced into the blood vessel or an indwelling needle punctured by the blood vessel is connected to the syringe via the extension tube. .. Therefore, before connecting the extension tube to the catheter or the like, an operation called "purge" is performed to remove the air existing in the extension tube from the extension tube. Regarding this purging, Patent Document 2 describes two syringes, a catheter, and the like as an example in the case of a chemical injection device having two piston drive mechanisms for operating these syringes, in which two syringes can be attached to the injection head. It is described that the extension tube (branch tube) is filled with a chemical solution by connecting with an extension tube also called a branch tube and simultaneously driving both piston drive mechanisms according to a predetermined operation by the operator to advance the piston of each syringe. Has been done.

Patent Document 1: International Publication No. 2006/068171 Patent Document 2: International Publication No. 2011/136218

In the injection of the drug solution by the drug solution injection device, as in the case of the above-mentioned angiography, the injection conditions of the drug solution may be changed and the drug solution may be repeatedly injected. To change the concentration of the contrast medium among the injection conditions, for example, an injection head capable of mounting two syringes is used, and a syringe filled with the contrast medium and a syringe filled with physiological saline are mounted on the injection head to perform contrast. It can be carried out by injecting the agent while diluting it with physiological saline.

However, even when the concentration of the contrast medium is changed and injected, the drug solution remaining in the extension tube remains at the contrast medium concentration before the change, so that the drug solution remaining in the extension tube at this point is used. After the injection, the drug solution is injected at the changed contrast medium concentration. Therefore, the time lag from the start of the injection operation of the chemical solution to the injection of the chemical solution having a desired contrast medium concentration becomes large. If the time lag becomes large, the imaging operation is executed at an imaging timing that is not an appropriate contrast medium concentration, and there is a risk that a good image cannot be acquired. In addition, as a result, an extra amount of contrast medium is injected, which increases the physical burden on the subject.

An object of the present invention is to provide a chemical solution injection device and a chemical solution injection system capable of arbitrarily changing the concentration of a chemical solution even in a purging operation, thereby solving the above-mentioned problems.

According to one aspect of the present invention, it is a chemical solution injection device that injects a chemical solution filled in a container.
A first drive mechanism configured to discharge the drug solution from the first container,
A second drive mechanism configured to discharge the drug solution from the second container,
At least an injection device control unit that controls the operation of the first drive mechanism and the second drive mechanism,
Have,
The injection device control unit receives an input of the degree of dilution of the chemical solution discharged from the first container by the chemical solution discharged from the second container, and uses at least the input degree of dilution to make the chemical solution. The discharge conditions of the chemical solution from the first and second containers in the purge operation performed prior to the injection of the drug solution are set, and the operation of the first and second drive mechanisms is controlled according to the set discharge conditions. A configured drug solution injection device is provided.

According to another aspect of the present invention, the above-mentioned chemical solution injection device of the present invention and
A first container and a second container that are detachably attached to the chemical injection device,
An injection circuit connected to the first container and the second container,
Provided is a drug solution infusion system with.

According to still another aspect of the present invention, the above-mentioned chemical injection system of the present invention and
A fluoroscopic imaging device that acquires a medical image from a subject who has been injected with a drug solution by the drug solution injection system.
A fluoroscopic imaging system is provided.

According to still another aspect of the present invention, the first container and the second container are detachably attached to the first drive mechanism for discharging the chemical solution from the first container and the chemical solution from the second container. A method of operating a chemical injection device provided with a second drive mechanism for releasing
A step of accepting an input of the degree of dilution of the chemical solution from the first container with the chemical solution from the second container, and
Using at least the input degree of dilution, a step of setting the discharge conditions of the chemical solution from the first and second containers in the purge operation performed prior to the injection of the chemical solution, and
The step of performing the purging operation by controlling the operation of the first and second piston drive mechanisms according to the set release conditions, and
A method of operating a chemical injection device having the above is provided.

(Definition of terms used in the present invention)
"Injection circuit" means a path for circulating a drug solution, which is connected to a container such as a syringe for injecting the drug solution into the blood vessel of the subject, and is a catheter or a subject inserted into the blood vessel of the subject. Includes an indwelling needle that is punctured into a blood vessel. Further, when a plurality of chemical solutions can be injected, the injection circuit further includes an extension tube having a plurality of branches on the terminal side connected to the container, and the tip of the extension tube is connected to the catheter or the indwelling needle. Further, at least one member such as another tube may be connected between the extension tube and the catheter or the indwelling needle. The injection circuit can be divided into an "external circuit portion" in which all are located outside the body and an "internal circuit portion" in which at least a part is located inside the body, depending on the arrangement at the time of use. According to this classification, the catheter or the indwelling needle belongs to the internal circuit, and the member connecting the container with the portion of the internal circuit located outside the body, such as the extension tube, belongs to the external circuit.

The "purge operation" means an operation of discharging the drug solution from the container in order to fill the extracorporeal circuit portion of the injection circuit with the desired drug solution prior to injecting the drug solution into the subject. When it also serves the purpose of discharging air inside the container and / or inside the extracorporeal circuit, it may be called "air bleeding". In this purging operation, the drug solution is not injected into the subject's body.

"Dilution degree" means the ratio of the amount of the other drug solution to the amount of the other drug solution when diluting one drug solution with the other drug solution.

"Purge amount" means the total amount of chemicals released from all the containers attached to the injection head in the purge operation.

According to the present invention, in the chemical solution injection device for injecting the chemical solution from the first and second containers, the degree of dilution of the chemical solution from each container in the purge performed prior to the chemical solution injection can be set. Purge operation is possible at any degree of dilution. This minimizes the time lag between wasteful injection of the drug solution and the dilution of the injected drug solution to the desired degree, resulting in a better image with a smaller amount of drug solution and a shorter time. Can be obtained.

It is a schematic block diagram of the fluoroscopic imaging system according to one Embodiment of this invention. It is a perspective view which shows an example of the appearance of the chemical liquid injection apparatus by one Embodiment of this invention. FIG. 5 is a perspective view showing the injection head shown in FIG. 2 together with a syringe assembly mounted therein. It is a figure which shows one form of the extension tube connected to a syringe. It is a figure which shows an example of the injection condition setting screen which is displayed when the injection condition is set in one Embodiment of this invention. FIG. 5 is a diagram showing an example of a screen displayed when the degree of dilution is changed when the injection mode is the dilution injection mode in the injection condition setting screen shown in FIG. It is a graph which shows an example of the relationship between the injection time and the injection rate of each drug solution in the purge operation which changes the release rate of each drug solution with time. It is a figure which shows another example of the dilution degree setting icon which can be displayed on the injection condition setting screen shown in FIG. It is a figure which shows an example of the dilution ratio input screen which can be used when setting the dilution ratio as an example of the degree of dilution. It is a schematic block diagram of the fluoroscopic imaging system when the chemical injection device includes an RFID module. It is a figure which shows the other form of the extension tube connected to a syringe schematically. It is a perspective view of the mixing device provided in the extension tube shown in FIG. 10A. It is sectional drawing of the mixing device provided in the extension tube shown in FIG. 10A.

Referring to FIG. 1, a block diagram of a fluoroscopic imaging system according to an embodiment of the present invention, which includes a chemical injection device 100 and a fluoroscopic imaging device 500, is shown. The chemical injection device 100 and the fluoroscopic imaging device 500 can be connected to each other so that data can be transmitted and received between them. The connection between the two can be a wired connection or a wireless connection. In the description described below, the case where the fluoroscopic imaging device 500 is an angio device and the drug solution injection device 100 is an injection device for angio examination suitable for injecting at least a contrast medium as a drug solution in an angio examination. Let's take an example. However, in the present invention, the fluoroscopic imaging device may be any fluoroscopic imaging device such as an X-ray CT device, an MRI device, and a PET device as long as it constitutes a system capable of performing an inspection or the like using a plurality of types of chemical solutions. The chemical injection device may also be any injection device compatible with these fluoroscopic imaging devices. Therefore, the configuration described in detail below can be appropriately changed according to the types of the fluoroscopic imaging device and the chemical injection device.

The fluoroscopic imaging device 500 includes an imaging operation unit 520 that executes an imaging operation and an imaging control unit 510 that controls the operation of the imaging operation unit 520, and the subject who has been injected with the drug solution by the drug solution injection device 100. Medical images including tomographic and / or 3D images can be acquired. The imaging operation unit 520 includes a bed for the subject, an electromagnetic wave irradiation unit that irradiates a predetermined space on the bed with electromagnetic waves, and the like. The imaging control unit 510 controls the operation of the entire fluoroscopic imaging device, such as determining imaging conditions and controlling the operation of the imaging operation unit 520 according to the determined imaging conditions. The image pickup control unit 510 can be configured by a so-called microcomputer, and can have an interface with a CPU, ROM, RAM, and other devices. A computer program for controlling the fluoroscopic imaging apparatus 500 is mounted on the ROM. The CPU controls the operation of each part of the fluoroscopic imaging apparatus 500 by executing various functions corresponding to this computer program.

The fluoroscopic imaging device 500 may further include a display unit 504 such as a liquid crystal display capable of displaying imaging conditions and acquired medical images, and an input unit 503 such as a keyboard and / or mouse for inputting imaging conditions and the like. it can. The data input from the input unit 503 is transmitted to the imaging control unit 510, and the data displayed on the display unit 504 is transmitted from the imaging control unit 510. Further, a touch panel in which a touch screen is arranged as an input unit on the display of the display unit can also be used as the input unit 503 and the display unit 504.

The drug solution injection device 100 is a device used for injecting a drug solution filled in a syringe, which is a container, into a blood vessel of a subject via an injection circuit, and is a device used to inject a plurality of piston drive mechanisms 130a and 130b and an input unit. It has a 103, a display unit 104, and an injection control unit 101. The piston drive mechanisms 130a and 130b are mechanisms for operating the piston of the syringe so as to discharge the chemical solution from the syringe. In this embodiment, the two syringes can be injected separately or simultaneously so that the two types of chemical solutions can be injected separately. It has two piston drive mechanisms 130a and 130b that operate the pistons independently. However, at least one of the piston drive mechanism 130a for injecting one chemical solution and the piston drive mechanism 130b for injecting the other chemical solution may be plural.

The injection control unit 101 determines injection conditions such as the injection amount and injection speed of the chemical solution, and controls and displays the operations of the piston drive mechanisms 130a and 130b so that the chemical solution is injected from the syringe according to the determined injection conditions. This chemical injection device, such as controlling the display of the unit 104 and setting purge conditions such as the discharge amount and the discharge rate of the chemical liquid discharged from the syringe in the purge operation performed prior to the injection of the chemical liquid into the subject. Control the overall operation. The injection control unit 101 can be configured by a so-called microcomputer and can have an interface with a CPU, ROM, RAM, and other devices. A computer program for controlling the chemical injection device 100 is mounted on the ROM. The CPU can control the operation of each part of the chemical solution injection device 100 by executing various functions corresponding to this computer program.

The input unit 103 is a unit used by the injection control unit 101 to input data necessary for determining the injection conditions of the drug solution. The input unit 103 may be, for example, a known input device such as a keyboard and / or mouse. The data input from the input unit 103 is transmitted to the injection control unit 101, and the data displayed on the display unit 104 is transmitted from the injection control unit 101. The display unit 104 is controlled by the injection control unit 101 to display data and the like necessary for determining the injection conditions of the drug solution, display the injection protocol, display the injection operation, display various warnings, and the like. The display unit 104 may be a known display device such as a liquid crystal display device. Further, a touch panel in which a touch screen is arranged as an input unit on the display of the display unit can also be used as the input unit 103 and the display unit 104.

Next, an example of the appearance of the chemical solution injection device 100 described above and the arrangement of each element will be described with reference to FIG. 2 and the like.

The drug solution injection device 100 shown in FIG. 2 is an example. It shows an injection device for an angiography device (angiography device), and has an injection head 110, a console 112, and a main unit 114. The injection head 110 and the console 112 are electrically connected via the main unit 114. In the illustrated form, the injection head 110 is rotatably supported on the upper part of the stand 116, but may be supported by a slewing arm fixed to the ceiling. The console 112 can include the input unit 103 and the display unit 104 described above. In the illustrated form, the console 112 includes a touch panel, which corresponds to the input unit 103 and the display unit 104 described above. The main unit 114 can include a power supply device (not shown), which can supply power to the injection head 110 and the console 112. The injection control unit 101 shown in FIG. 1 may be arranged in the main unit 114 or may be arranged in the console 112.

As shown in FIG. 3, the injection head 110 is configured so that two sets of syringe assemblies 200 can be detachably attached (in FIG. 4, only one set of syringe assemblies 200 is shown for simplification. There is).

The syringe assembly 200 has a syringe 220 and a protective cover 270 into which the syringe 220 is inserted. The syringe 220 is generally called a rodless syringe, and includes a cylinder 221 having a flange 221a formed at the end and a nozzle portion 221b formed at the tip, and a piston 222 inserted into the cylinder 221 so as to be movable back and forth. have.

As the piston 222 moves toward the tip of the cylinder 221 the filled chemical solution is pushed out of the syringe 220 through the nozzle portion 221b. An extension tube 300, for example, as shown in FIG. 4, which constitutes an extracorporeal circuit portion of the injection circuit, can be connected to the tip of each syringe 220. The extension tube 300 has a first tube 301, a second tube 302, a third tube 303, and a T-shaped connector 304 connecting them, and as a whole, takes the form of a branch tube having a branched end side. ing. The first tube 301 and the second tube 302 have connectors 305 and 306 at their ends for connection with the nozzle portion 211b of the syringe 220, respectively. The third tube 303 has a connector 307 at its tip for connecting to a catheter or the like.

At least one of the connectors 305 and 306 connected to the first tube 301 and the second tube 302, respectively, may include a one-sided valve. On the other hand, the valve has a valve body that operates by the back pressure of the fluid to close the flow path, and the syringe 220 is connected from the end side to the tip side of the extension tube 300, that is, the side to which the catheter or the like is connected. It works to prevent backflow of fluid to the side. Further, at least one of the valves may have a release function capable of arbitrarily holding the valve body in the open position of the flow path by a predetermined operation. On the other hand, since the valve has a release function, it is usually possible to prevent blood from flowing back toward the syringe 220, but blood is used to confirm whether the tip of a catheter or the like is normally located in the blood vessel of the subject. It enables so-called route check and the like to suck.

With such an extension tube 300 connected to the two sets of syringe assemblies 200, the end of the internal circuit portion such as a catheter inserted into the blood vessel of the subject is connected to the third tube 303 to give the subject a drug solution. Is ready to be injected. As the chemical solution to be filled in the syringe 220, for example, the contrast agent is filled in the syringe 220 connected to the first tube 301, and the syringe 220 connected to the second tube 302 is filled in physiological. It can be a saline solution. Alternatively, a syringe 220 filled with contrast media having different concentrations may be connected to the first tube 301 and the second tube 302, respectively.

The contrast medium used for capturing a medical image has a relatively high viscosity, and in particular, the contrast medium used for capturing an image with an angio device has a higher viscosity than other types of contrast media. Moreover, the catheter is generally extremely thin with an inner diameter of less than 1 mm. Therefore, when a contrast medium is filled in the syringe 220 as a chemical solution and the piston 222 is advanced in order to inject the contrast medium, a very high internal pressure is generated in the cylinder 221. This high internal pressure may cause the cylinder 221 to expand and cause various problems in the injection of the contrast medium.

The protective cover 270 suppresses expansion due to an increase in the internal pressure of the cylinder 221 when injecting a chemical solution, and is a cylinder sized so that when the cylinder 221 is inserted, there is almost no gap between the cylinder 221 and its outer peripheral surface. It is a shaped member. In order for the protective cover 270 to play this role, the protective cover 270 is preferably formed with a wall thickness having mechanical strength sufficient to withstand the internal pressure acting on the cylinder 221 during injection of the chemical solution.

An opening through which the nozzle portion 221b of the syringe 220 passes is formed at the tip of the protective cover 270, and the syringe 220 is held in a state where the nozzle portion 221b protrudes from this opening. At the end of the protective cover 270, a cover flange 271 having a ring-shaped recess formed on the end surface for receiving the flange 221a of the cylinder 221 is formed.

The injection head 110 is provided with first and second piston drive mechanisms 130a, 130b (see FIG. 1) that are driven independently of each other to advance and retract the pistons 222 of the two mounted syringe assemblies 200. , Each syringe assembly 200 is arranged corresponding to the mounting position. Each of the piston drive mechanisms 130a and 130b includes a presser 131 that holds a convex portion formed at the end of the piston 222, a drive source such as a motor that moves the presser 131 forward and backward, and a power transmission mechanism that connects them. Has.

The syringe assembly 200 mounted on the injection head 110 can inject the drug solution filled in the syringe 220 into the subject separately or simultaneously by advancing the piston 222 by the piston drive mechanisms 130a and 130b. it can. For the piston drive mechanism 130, a known mechanism generally used for this type of injection device can be adopted.

The tip of the injection head 110 is provided with a syringe receiver 120 and a clamper 140 that form a syringe mounting portion on which the syringe assembly 200 is mounted. The syringe receiver 120 is located on the distal end side of the clamper 140 and has two recesses 121 so as to individually receive the outer peripheral surface of each syringe assembly 200. The clamper 140 is openable and closable to the syringe receiver 120 and is configured to individually hold the cover flange 271 of the protective cover 270 of each syringe assembly 200. Each syringe assembly 200 is located in the recess 121 with the nozzle portion 221b facing the tip side, and the syringe assembly 200 is fixed to the injection head 110 by closing the clamper 140.

The protective cover 270 is not an essential configuration in the present invention, and the syringe 220 may be directly attached to the injection head 110. That is, the present invention includes both those in which the syringe 220 is directly attached to the injection head 110 and those in which the syringe 220 is indirectly attached via other members.

The injection head 110 can have an exterior cover 125 that covers the entire mechanism except for the portion having the syringe receiver 120 and the clamper 140. In this case, the exterior cover 125 may have a sign 125a at a position corresponding to each presser 131 to distinguish the corresponding presser 131. The sign 125a may be arbitrary such as a letter or a symbol, and in this embodiment, the letters "A" and "B" are used. This label can also be used to distinguish the syringe 220 (chemical solution) on the injection condition setting screen 400 (see FIG. 5) described later. In the following description, the chemical solutions filled in the syringe 220 attached to the syringe receiver 120, respectively, corresponding to the label 125a may be referred to as “chemical solution A” and “chemical solution B”.

With reference to FIG. 2 again, the chemical injection device 100 may further include a hand switch 118 and / or a foot switch 119 as an option. The hand switch 118 has an operation button, which can be used to control the start and stop of the injection operation so that the injection head 110 performs the injection operation of the drug solution only while the operation button is pressed. it can. The foot switch 119 is used to control the start and stop of the injection operation so that the injection head 110 performs the injection operation of the chemical solution only while the foot switch 119 is stepped on, for example, when performing a test injection. Can be done.

"Test injection" is performed as necessary prior to imaging for the acquisition of medical images, such as to grasp individual differences in contrast effect and / or to confirm the tip position of the injection circuit. It is an injection of a chemical solution. The injection of the drug solution for the acquisition of medical images is sometimes referred to as the "main injection" to distinguish it from this test injection. In a test injection, a smaller amount of drug solution is usually injected than in the main injection. In addition, the injection rate of the drug solution in the test injection is usually set in advance or set to be the same as the injection rate of the drug solution in the main injection. This test injection can also be performed by operating the hand switch 118. In this case, if the hand switch 118 is operated when the setting of the drug solution injection protocol is completed and the injection preparation is ready (standby state), the main injection is executed, but the hand switch 118 is operated at the stage before that. If so, the test injection can be performed.

Next, an example of the procedure for injecting the drug solution using the fluoroscopic imaging system described above will be described.

First, the operator turns on the power of the chemical injection device 100. Then, the syringe assembly 200 filled with the drug solution to be poured into the subject is attached to the injection head 110. Alternatively, after mounting an empty syringe assembly 200 not filled with the chemical solution to the injection head 110, a chemical solution container (not shown) is connected to the nozzle portion 221b via an appropriate tube, and in that state, the piston drive mechanism is used. By retracting the piston 222 and filling the syringe assembly 200 with the chemical solution, the syringe assembly 200 filled with the chemical solution may be attached to the injection head 110. Regarding the syringe 220 that constitutes a part of the syringe assembly 200, in the present specification, the syringe 220 that is filled with the chemical solution by the manufacturer as in the former is called a prefilled type, and is filled with the chemical solution in the medical field as in the latter case. The one is also called a post-filling type.

The syringe assembly 200 can be attached to the injection head 110, for example, by the following procedure. First, with the clamper 140 in the open position, the operator places the syringe assembly 200 on the recess 121 of the syringe receiver 120. At this time, the convex portion of the piston 222 at the rear end position is held by the presser 131. Once the syringe assembly 200 is placed on the recess 121, the operator closes the clamper 140, which holds the syringe assembly 200 in the injection head 110.

The injection head 110 preferably has a locking mechanism (not shown) that locks the clamper 140 so that it can be opened at the closed position. The locking mechanism may be any mechanism as long as the clamper 140 can be locked and released at the closed position. By having the locking mechanism, it is possible to prevent the syringe assembly 200 attached to the injection head 110 from coming off the injection head 110.

Here, the injection head 110 preferably includes at least one detector that detects that the syringe assembly 200 is attached to the injection head 110. The attachment of the syringe assembly 200 to the injection head 110 detects, for example, that the first detector for detecting that the syringe assembly 200 is placed on the syringe receiving recess 121 and the clamper 140 are in the closed position. It can be detected by a second detector. As the first detector, for example, a detector that is arranged in the syringe receiving recess 121 and can detect the syringe assembly 200 in the syringe receiving recess 121 can be used. As the second detector, for example, a detector built in the injection head 110 and capable of detecting the tip portion of the clamper 140 when the clamper 140 is in the closed position can be used.

All of these detectors can detect an object to be detected, such as a syringe assembly 200 or a clamper 140, when the distance between the detector and the detector is less than a predetermined distance (including contact). Specifically, it may be an optical sensor that optically detects the presence or absence of an object in the detection region, a proximity sensor that detects the presence or absence or position of an object using magnetism as a detection medium, or contact with an object to be detected. / A mechanical switch that switches on / off by non-contact can be used. As the mechanical switch, any switch including, for example, a tact switch and a limit switch can be used as long as it is switched on / off by contact / non-contact of the object to be detected. It should be noted that the injection head 110 does not need to include both a first detector and a second detector in order to detect that the syringe assembly 200 is attached to the injection head 110, and only one of them is required. It may be.

By making it possible to detect that the syringe assembly 200 has been mounted on the injection head 110 in this way, for example, the injection control unit 101 displays information indicating that the syringe assembly 200 has been mounted on the display unit 104. It can be displayed to visually notify the operator, and further, the operation of the chemical solution injection device 100 can be moved to the next step.

At this time, the information displayed on the display unit 104 may be a text message or information represented by symbols. Further, a light emitting lamp (not shown) is provided separately from the display unit 104, and the injection control unit 101 lights the light emitting lamp to visually notify the operator that the installation of the syringe assembly 200 is completed. it can. In this case, the light emitting lamp can be provided on the injection head 110. The position of the light emitting lamp provided on the injection head 110 may be arbitrary, but it is preferably near the site where the operator last operates when mounting the syringe assembly 200, for example, near the clamper 140. In particular, as in the embodiment shown in FIG. 3, the injection head 110 is provided with a marker 125a (specifically, the letters "A" and "B") for identifying the two piston drive mechanisms 130a and 130b. It is preferable to arrange two light emitting lamps so that each of these labeled portions emits light as a light emitting portion. The color visually recognized by lighting the light emitting lamp may be arbitrary, or may be a different color for each corresponding chemical solution, such as blue and green. The injection head 110 may also have a light emitting unit 126 that emits light by lighting another light emitting lamp that emits light in the standby state described above. In the form shown in FIG. 3, a plurality of light emitting units 126 arranged at positions separated from each other are provided, but by doing so, it is possible to visually recognize that the standby state is in any direction.

After the attachment of the syringe assembly 200 to the injection head 110 is completed as described above, the injection control unit 101 executes an operation for injecting the drug solution. This operation can include, for example, a series of steps shown below.
(1) Acceptance of data input and setting of injection conditions (2) Purge operation (3) Execution of injection operation according to the set injection conditions (4) Injection operation end processing These processes will be described in order below. ..

(1) Acceptance of data input and setting of injection condition In this step, the injection control unit 101 causes the display unit 104 to display the screen for setting the injection condition, and inputs the input unit 103 for setting the injection condition. Allows operation.

FIG. 5 shows an example of the injection condition setting screen 400. The injection condition setting screen 400 shown in FIG. 5 has an injection mode icon 401, a quick memory icon 402, a confirmation icon 403, a speed setting icon 404, an injection amount setting icon 405, an injection time setting icon 406, a dilution degree setting icon 407, and a syringe. The information icon 408, the purge icon 409, and the like can be included.

The syringe information icon 408 graphically displays information about the syringe 220 mounted on the injection head 110 (see FIG. 3). The information displayed on the syringe icon 408 can include the amount of the drug solution filled in the attached syringe 220. Further, during the injection operation of the chemical solution, the operator can visually recognize the injection operation of the chemical solution by displaying an arbitrary animation.

The injection mode icon 401 is an icon indicating which injection mode is used to execute the injection operation among the plurality of injection modes preset in the injection control unit 101. As the injection mode, for example, "normal injection mode" in which only the drug solution A is injected, "flash mode" in which the drug solution B is injected after the injection of the drug solution A is completed, and "dilution" in which the drug solution A and the drug solution B are injected at the same time. Examples include "mode" and "multi-mode" in which only the drug solution A is injected in a plurality of phases. FIG. 5 shows a state in which the “dilution mode” is selected. When the operator taps the injection mode icon 401, the injection control unit 101 switches the display of the injection mode icon 401, whereby the injection mode can be switched.

The quick memory icon 402 is operated when calling the injection condition registered in the memory of the injection control unit 101. The confirmation icon 403 is operated when the operator approves the injection condition displayed on the injection condition setting screen 400, and when the confirmation icon 403 is tapped, the injection control unit 101 presses the chemical solution injection device 100. The standby state enables the transition to the next step of the chemical injection procedure.

The speed setting icon 404, the injection amount setting icon 405, and the injection time setting icon 406 are used to set the injection rate, injection amount, and injection time of the drug solution, respectively. For example, when setting the injection speed, when the operator taps the speed setting icon 404, the injection control unit 101 overlaps and displays a numeric keypad icon (not shown) for inputting the injection speed on the injection condition setting screen 400. Let me. The injection speed can be set by the operator inputting and confirming a numerical value through this numeric keypad screen. The injection amount and injection time can be set in the same manner as the injection rate setting. The numeric keypad icon may be, for example, the same as the numeric keypad icon 431 (see FIG. 6) on the ratio setting screen 430 described later. Further, in the "dilution injection mode", the speed setting icon 404 and the injection amount setting icon 405 set the total injection rate and injection amount of the chemical solution A and the chemical solution B.

The dilution degree setting icon 407 is an icon that is operated in setting the ratio of the target drug solution to the reference drug solution that is injected in the dilution injection mode. There are several ways to express the degree of dilution, but in this embodiment, based on the idea of diluting the drug solution A with the drug solution B, the amount of the drug solution A with respect to the total amount of the drug solution A and the drug solution B, that is, the drug solution A It is expressed as a dilution ratio calculated by / (chemical solution A + chemical solution B). This means, for example, that when the drug solution A is a contrast medium and the drug solution B is a physiological saline solution, when the contrast medium is diluted with the physiological saline solution, the ratio of the contrast medium to the total amount is contained. Means. The dilution ratio may be set to, for example, 50% as a default value.

The dilution ratio can be set, for example, as follows.

When the operator taps the dilution degree setting icon 407, the injection control unit 101 pops up the dilution ratio input screen 430 as shown in FIG. 6 on the injection condition setting screen 400, or the injection condition setting screen. The display is switched from 400 to the dilution ratio input screen 430. The dilution ratio input screen 430 can have a numeric keypad icon 431 and a ratio setting bar 432. With the numeric keypad icon 431, the ratio of the amount of the chemical solution A to the total amount of the chemical solution A and the chemical solution B can be set numerically. When the operator operates the numeric keypad icon 431 and inputs a numerical value, the injection control unit 101 determines the input numerical value as the dilution ratio.

On the other hand, the ratio setting bar 432 can have a ratio display unit 432a and a slider icon 432b. The ratio display unit 432a shows the ratio of the chemical solution A and the chemical solution B as a band graph, and the slider icon 432b is displayed so that the operator can move the ratio along the ratio display unit 432a while touching it. Is controlled. When the position of the slider icon 432b is moved by the operator, the injection control unit 101 sets the dilution ratio to a ratio corresponding to the position of the slider icon 432b. In order to make it easier to visually recognize the dilution ratio, the ratio display unit 432a may display the chemical solution A side and the chemical solution B side in different colors with the position of the slider icon 432b as a boundary.

The dilution ratio can be set from any of the numeric keypad icon 431 and the ratio bar 432. Further, the dilution ratio input screen 430 may have only one of the numeric keypad icon 431 and the ratio bar 432. Further, the input of the dilution ratio is not limited to the above method, and any method can be used.
When the dilution ratio is set, the injection control unit 101 either eliminates the pop-up display of the dilution ratio input screen 430 from the injection condition setting screen 400 or turns off the injection condition setting screen according to the display form of the dilution ratio input screen 430. The display is switched to 400, and the set dilution ratio is displayed on the dilution ratio icon 407 on the injection condition setting screen 400.

The operator performs a data input operation as necessary according to the display on the injection condition setting screen 400. When the input of all the data for setting the injection conditions is completed and the operator taps the confirmation icon 403, the display is switched to "Start OK", and the chemical solution injection device 100 is in the standby state where the chemical solution can be injected. Become.

(2) Purge operation The purge operation is performed after the extracorporeal circuit portion (for example, extension tube) of the injection circuit is connected to the syringe assembly 200 and before the injection operation of the chemical solution is started, and the purge operation is performed. Then, the chemical solution in the syringe 220 releases the air in the extracorporeal circuit portion and the fluid containing the chemical solution from the injection circuit. Since the fluid inside the extracorporeal circuit is discharged from the injection circuit, the purge operation is performed when the tip of the extracorporeal circuit is not connected to the end of the internal circuit, or a three-way stopcock between the extracorporeal circuit and the internal circuit. Is performed with the three-way stopcock switched so that the drug solution is discharged from the side tube connected to the remaining port of the three-way stopcock. Further, the purge operation is basically performed to fill the inside of the extracorporeal circuit part with the chemical solution when the extracorporeal circuit part is not filled with the chemical solution, and it is necessary to perform the purge operation when the extension tube 300 is filled with the chemical solution. There is no. However, if the dilution ratio is changed, for example, when the second injection is performed at a dilution ratio different from that of the first injection after the first injection, purging even if the extracorporeal circuit part is filled with the chemical solution. It is preferable to perform the operation.

The trigger for performing the purge operation is given by the operator. For this purpose, for example, the injection head 110 can have a purge button 123 (see FIG. 3). Alternatively, as shown in FIG. 5, the purge icon 409 can be displayed on the injection condition setting screen 400. Furthermore, both the purge button 123 and the purge icon 409 can be provided.

When the operator presses the purge button 123 or taps the purge icon 409, the injection control unit 101 executes the purge operation. When two syringes 220 are attached to the injection head 110, conventionally, a purging operation is performed so that the drug solution is discharged from each syringe 220 at the same discharge amount and discharge rate, and purge conditions such as these discharge amounts and discharge rates are performed. Could not be changed. In the present embodiment, the injection control unit 101 sets a release ratio, which is the ratio of the release amount of the drug solution A to the total of the release amount of the drug solution A and the release amount of the drug solution B, and the drug solution is released according to the set release ratio. The operation of the piston drive mechanisms 130a and 130b is controlled in this way.

The release ratio in the purging operation preferably follows the dilution ratio, which is one of the injection conditions of the chemical solution. As described above, the injection control unit 101 accepts the input of the dilution ratio through the injection condition setting screen 400, and the release ratio is set to a value equal to the dilution ratio input here. As a result, the drug solution A and the drug solution B are released from each syringe 220 in the amount of the drug solution A and the amount of the drug solution B according to the dilution ratio. When the extracorporeal circuit part is an extension tube (see FIG. 4), the chemical solution A and the chemical solution B discharged from each syringe 220 pass through the first tube 301 and the second tube 302 in the extension tube 300, respectively. , Converging in the third tube 303, where it is made into a mixed solution of the chemical solution A and the chemical solution B. The concentration of the drug solution A in this mixture is equal to the concentration of the drug solution A diluted at the set dilution ratio.

As a method of controlling the operation of the piston drive mechanisms 130a and 130b for discharging the chemical solution at the set release ratio, the release speed, that is, the control based on the moving speed of the presser 131 of the piston drive mechanisms 130a and 130b, and the release amount That is, control based on the amount of movement of the piston drive mechanisms 130a and 130b can be mentioned.

In the control based on the release rate, as described above, when the injection condition is set, the injection control unit 101 receives the input of the total injection rate of the chemical solution A and the chemical solution B via the injection condition setting screen 400. The operation of the piston drive mechanisms 130a and 130b can be controlled by using the injection speed input here, for example, as follows.

If the syringe 220 filled with the chemical solution A and the syringe 220 filled with the chemical solution B are both the same size, the set dilution ratio is R (%), and the chemical solution A entered using the speed setting icon 404. The total injection rate of the drug solution B is St (mL / sec), the release rate of the drug solution A in the purge operation is Sa (mL / sec), and the release rate of the drug solution B in the purge operation is Sb (mL / sec). When
Sa (mL / sec) = St (mL / sec) x R (%)
Sb (mL / sec) = St (mL / sec) -Sa (ml / sec)
The piston drive mechanisms 130a and 130b are operated so as to be. By doing so, the purging operation can be performed at the same release ratio as the set dilution ratio. In this case, the two piston drive mechanisms 130a and 130b can be operated simultaneously and for the same amount of time, but the length of time may be arbitrary.

On the other hand, in order to fill the inside of the external circuit portion with the chemical solution A and the chemical solution B, it is preferable that the total amount of the chemical solution A and the chemical solution B discharged from the two syringes 220 is equal to or larger than the volume of the external circuit portion. Therefore, if the purge amount, which is the total amount of the chemical solution A and the chemical solution B released during the purge operation, is determined in advance in consideration of the volume of the extracorporeal circuit part that is expected to be used, the control based on the release amount can be performed. The inside of the extracorporeal circuit portion can be filled with the chemical solution A and the chemical solution B.

The purge amount may be an amount that can fill the extracorporeal circuit portion with a desired chemical solution, and the amount is smaller than the injection amount set as one of the injection conditions of the chemical solution. Therefore, it is preferable that the purge amount is set in the injection control unit 101 separately from the injection amount at the time of injecting the drug solution. The preferred value of the purge amount depends on the volume of the extracorporeal circuit part used, but is generally 5 mL to 10 mL.

In this way, when the purge amount is predetermined, the set dilution ratio is R (%), the purge amount is Dt (mL), the release amount of the chemical solution A in the purge operation is Da (mL), and the purge operation is used. When the amount of chemical solution B released is Db (mL),
Da (mL) = Dt (mL) x R (%)
Db (mL) = Dt (mL) -Da (mL)
The piston drive mechanisms 130a and 130b are operated so as to be. By doing so, the purging operation can be performed at the same release ratio as the set dilution ratio. In this case, the operation timings of the piston drive mechanisms 130a and 130b may be simultaneous or different. However, in order to perform a more reliable purging operation without generating air bubbles in the extension tube 300, it is preferable to drive the two piston drive mechanisms 130a and 130b at the same time and for the same time.

When the purge amount is predetermined, the discharge rate of the chemical solution in the purge operation is arbitrary as long as the final discharge amount is a desired amount, and is the same as the injection rate set as the chemical solution injection condition. It may or may not be different. Further, the release rate may be constant during at least a part of the time from the start to the end of the purge operation, or may be changed over time.

For example, the injection control unit 101 discharges both drug solutions at the same release rate at the start of the purge operation, and then, until the end of the purge operation, the release rate of at least one of the drug solutions is stepped over time. The conditions for releasing the drug solution in the purging operation can be set so that the final dilution degree becomes the desired dilution degree by changing the target or continuously.

Alternatively, as shown in FIG. 7, the injection control unit 101 releases only the drug solution B (for example, a contrast medium) at the start of the purge operation, and then sets the release rate of the drug solution A for a period of time until the end of the purge operation. While decreasing with the passage of time, the release rate of drug solution A (for example, physiological saline) is increased from zero with the passage of time, and purged so that the final dilution is the desired dilution. It is also possible to set the release conditions of the chemical solution in operation. In this case, it is preferable to set the release conditions of each drug solution so that the total release rate of the drug solution A and the drug solution B becomes constant. Further, the relationship between the chemical solution A and the chemical solution B may be reversed. Note that FIG. 7 shows a case where the degree of dilution is chemical solution A: chemical solution B = 1: 1. In this case, when both chemical solutions are released so that the total release rate of both chemical solutions is constant, the purging operation is performed. The release rate of the chemical solution released at the start of the operation gradually decreases, and the release rate becomes zero at the end of the purge operation.

In the above example, regarding the release of the chemical solution at the start of the purge operation, the case where the release rates of the chemical solution A and the chemical solution B are the same, and the case where only one of the chemical solutions is released have been described. However, the present invention is not limited to these, and the ratio of the release rate of the drug solution A to the release rate of the drug solution B at the start of the purge operation may be arbitrarily set. Also, regarding the increasing and decreasing tendency of the release rate, the release rate of each chemical solution is changed so as to achieve the desired predetermined dilution before the end of the purge operation, and thereafter, the release rate of each chemical solution until the end of the purge operation. Release conditions may be set so that

As described above, by changing the release rates of the chemical solution A and the chemical solution B over time during at least a part of the purge operation, both chemical solutions are mixed more uniformly in the extracorporeal circuit section and from the extracorporeal circuit section. Bubbles can be eliminated satisfactorily. When the ratio of both chemicals released in the purge operation is significantly different, both chemicals are sufficient in the purge operation, although it depends on the characteristics of the injection circuit and the difference in the physical property values (viscosity, specific gravity, etc.) of each chemical to be mixed. In some cases, the bubbles may not be mixed with the mixture or the bubbles may not be surely eliminated. In such a case, the release control as described above is effective.

When the extracorporeal circuit part is not filled with the chemical solution, the purging operation is performed in a state where the extracorporeal circuit part is not connected to the extracorporeal circuit part, and the extracorporeal circuit part is inside the body by the operator after the completion of the purging operation. It is connected to the circuit section.

When the extracorporeal circuit part is not filled with the chemical solution, the purge operation is performed by operating the purge button 123 or the like even in an injection mode other than the above-mentioned dilution injection mode, for example, a normal injection mode in which only the contrast medium is injected. It is possible. However, when injecting only the contrast medium, it can be considered as a special case where the dilution ratio is 0% in the dilution injection mode. In this case, if the above procedure is applied, the purging operation is performed only by releasing the contrast medium. Will be done. However, in a state where the extracorporeal circuit part is not filled with the chemical solution, the extracorporeal circuit part has a part in which only one of the chemical solutions flows until both chemical solutions merge, so that the extracorporeal circuit part only releases the contrast medium. It is difficult to fill the whole with a chemical solution. Therefore, when only one of the chemical solutions is injected, it is preferable to perform a purging operation so that the chemical solution is released at a predetermined constant dilution ratio, for example, the above-mentioned default value.

(3) Execution of injection operation according to the set injection conditions As described above, after the display is switched to "Start OK" by tapping the confirmation icon 403, the hand switch 118 is operated, thereby operating the injection control unit. The 101 operates the piston drive mechanisms 130a and 130b, and the chemical injection operation is started. The hand switch 118 may be a momentary operation type switch, and in this case, the piston drive mechanisms 130a and 130b operate only while the button of the hand switch 118 is pressed. The injection operation of the chemical solution can also be started by a command from the interlocking fluoroscopic imaging device 500.

The injection operation of the chemical solution is performed by the injection control unit 101 controlling the operation of the piston drive mechanisms 130a and 130b so that the chemical solution is injected under the set injection conditions (injection speed, injection amount, injection time, etc.). Will be. When the injection mode is the dilution injection mode, both piston drive mechanisms 130a and 130b are operated at the same time so that the chemical solution A and the chemical solution B are injected at the set dilution ratio. Here, a purge operation is executed prior to the injection operation, and the tip side of the confluence portion of the extracorporeal circuit portion (for example, the T-shaped connector 304 of the extension tube 300 shown in FIG. 4) is already at a desired dilution ratio. Since the drug solution is filled in the diluted state, the drug solution diluted at the desired dilution ratio is immediately injected when the injection operation is started. This minimizes the time lag between wasteful injection of the drug solution and the dilution ratio of the injected drug solution to the desired ratio, resulting in a better image with a smaller amount of drug solution and a shorter time. Can be obtained.

Actually, when the injection operation is started, the chemical solution remaining in the internal circuit portion is injected, and then the chemical solution in the external circuit portion is injected. Therefore, if the extracorporeal circuit part used is new and the inside is filled with physiological saline, or if the dilution ratio at the time of the previous injection is different from the dilution ratio of this time, the desired dilution ratio can be obtained. Different saline solutions may be injected first. However, usually, a catheter used for injecting a contrast medium as an internal circuit portion is often used with an inner diameter of 2 mm or less and an effective length of about 1 m. Therefore, the volume of the catheter is extremely small compared to the amount of the drug solution injected in one examination.

On the other hand, the fluoroscopic imaging device 500 starts the imaging operation in response to the chemical solution injection operation by the chemical solution injection device 100. The imaging operation by the fluoroscopic imaging device 500 may be executed by the operation by the operator as a trigger, or may be automatically executed in conjunction with the injection operation by the chemical solution injection device 100. When the injection operation and the imaging operation are linked, for example, the injection operation is performed so that the imaging operation is started after a predetermined time required for the injected drug solution to reach the target site after the injection operation is started. At the same time as the start, the injection control unit 101 of the chemical injection device 100 transmits an injection start signal to the image pickup control unit 510 of the fluoroscopic image pickup device 500, and the image pickup control unit 510 that receives the injection start signal receives the injection start signal after the elapse of the predetermined time, the image pickup operation unit 520 The injection control unit 101 transmits an injection start signal to the imaging control unit 510 after the predetermined time has elapsed since the injection operation was started, and the imaging control unit 510 receives the injection start signal. Immediately after reception, the imaging operation unit 520 can be controlled to start the imaging operation.

The image pickup control unit 510 can reconstruct the data obtained by the image pickup operation of the image pickup operation unit 520 to acquire a medical image, and display the acquired medical image on the display unit 504 in real time. Further, if the data of the injection conditions such as the injection speed, the injection amount, the injection time, and the injection pressure of the chemical solution are transmitted from the injection control unit 101 to the imaging control unit 510, the imaging control unit 510 is transmitted to the display unit 503. Part or all of the injection conditions can be displayed in real time together with or separately from medical images and imaging conditions.

By displaying part or all of the injection conditions in real time, for example, in the case of repeating image imaging and drug solution injection multiple times while changing the site in liver examination and treatment, the cumulative total up to the imaging stage. The injection amount and the X-ray irradiation amount can be displayed. By doing so, it is determined on the spot whether the cumulative X-ray irradiation amount does not exceed the standard value and whether the injection amount of the contrast medium for a subject with poor liver function does not exceed the standard value. When the X-ray irradiation amount and / or the injection amount is likely to exceed the reference value, the X-ray irradiation amount and the injection amount of the contrast medium can be adjusted as necessary.

(4) Injection operation end processing After the injection operation is completed, the injection control unit 101 can display the injection result on the display unit 104 as one of the injection operation end processes. Examples of displayed results include injection end date and time, injection mode, set imaging site, injection rate, injection volume, dilution ratio (in the case of dilution injection mode), time required for injection, maximum pressure during injection, etc. Is mentioned and may be displayed at least one of these items. Further, the injection control unit 101 records these injection results in an appropriate memory device inside or outside the chemical injection device 100 or transmits them to the fluoroscopic imaging device 500 as one of the injection operation termination processes. Can be done.

When the injection operation end process is completed, the injection control unit 101 can display the injection condition setting screen 400 on the display unit 104 again by a predetermined operation by the operator. When the drug solution is repeatedly injected under different conditions or the same conditions for the next test or treatment, the injection conditions can be set on the injection condition setting screen 400, and the drug solution can be injected under the set injection conditions. it can. In particular, when the injection mode is the dilution injection mode and the dilution ratio is changed from the previous time, the purge operation is performed. As a result, even in the next injection, a good image can be obtained with a smaller amount of chemical solution and a shorter time.

Although the present invention has been described above with reference to typical embodiments, the present invention is not limited to the above-described embodiments.

(Another expression of dilution)
In the above-mentioned form, an example in which the degree of dilution is expressed by the dilution ratio is shown. However, the degree of dilution can also be expressed as a dilution factor. In this case as well, based on the idea of diluting the drug solution A with the drug solution B as in the above-mentioned idea of the dilution ratio, the dilution ratio is the total amount of the drug solution A and the drug solution B with respect to the amount of the drug solution A, that is, (chemical solution A +). Calculated as chemical solution B) / chemical solution A. For example, when the chemical solution A: the chemical solution B = 1: 1, the dilution ratio described above is 50%, but the dilution ratio is 2 times. These represent the same degree of dilution in different ways.

When the degree of dilution is expressed by the dilution ratio, the screen for setting injection conditions and the like are also changed as necessary. For example, the dilution degree setting icon 407 displayed on the injection condition setting screen displays the currently set dilution ratio as shown in FIG. 8A. Further, when the operator taps the dilution degree setting icon 407 when changing the dilution degree, the injection control unit 101 pops up the dilution ratio input screen 440 as shown in FIG. 8B on the injection condition setting screen, for example. ..

The dilution ratio input screen 440 can have at least one of the numeric keypad icon 441 and the magnification setting bar 442, similar to the dilution ratio input screen 430 shown in FIG. With the numeric keypad icon 441, the dilution ratio represented by the total amount of the chemical solution A and the chemical solution B with respect to the amount of the chemical solution A can be set numerically. When the operator operates the numeric keypad icon 441 to input a numerical value, the injection control unit 101 determines the input numerical value as the dilution ratio.

On the other hand, the magnification setting bar 442 can have a magnification display unit 442a and a slider icon 442b. The magnification display unit 442a shows the set magnification in a logarithmic graph format. By displaying the magnification display unit 442a in a logarithmic graph, the operator can intuitively grasp the ratio of the chemical solution A and the chemical solution B. The display position of the slider icon 442b is controlled so that the operator can move it along the magnification display unit 442a while touching it. When the position of the slider icon 442b is moved by the operator, the injection control unit 101 sets the dilution ratio to a magnification corresponding to the position of the slider icon 442b. Further, similarly to the dilution ratio input screen 430, the chemical solution A side and the chemical solution B side may be displayed in different colors with the position of the slider icon 442b as a boundary.

The injection control unit 101 sets a purge condition in the purge operation using the dilution ratio input in this way as one of the parameters, and during the purge operation, the piston drive mechanisms 130a and 130b operate according to the set purge condition. To control. The control of the operation of the piston drive mechanisms 130a and 130b during the purge operation by the injection control unit 101 may be the same as when the purge condition is set based on the dilution ratio.

(Purge operation different from the degree of dilution at the time of injection)
For example, in the above-described embodiment, the case where the purging operation is performed so that the drug solution A and the drug solution B are discharged from the syringe 220 at a dilution degree equal to the dilution degree at the time of injection has been described. However, it is also possible to perform the purge operation at a dilution degree different from the dilution degree.

For example, when the drug solution A is a contrast medium and the drug solution B is a physiological saline solution, the contrast medium has an extremely high viscosity as compared with the physiological saline solution and does not easily flow in the extracorporeal circuit portion. Therefore, when the contrast medium is diluted with physiological saline, if the ratios of the two amounts are significantly different, a small amount of release such as a purge operation may cause uneven dilution in which the contrast medium and physiological saline are not sufficiently mixed. , Bubbles in the extracorporeal circuit may not be eliminated. Therefore, when the ratio of the injection amount of the contrast medium and the physiological saline is significantly different in this way, the contrast medium amount: the physiological saline amount = 1: 1, in other words, the contrast medium, regardless of the amount ratio to be injected. It is also possible to perform the purging operation at a constant amount ratio so that the dilution ratio is 50%.

For that purpose, for example, the injection control unit 101 is set in advance with a reference value of the degree of dilution, which performs the purging operation at a ratio other than the amount to be injected, and the injection control unit 101 sets the injection conditions. The degree of dilution of the contrast agent (drug solution A) with respect to the total injection amount of the contrast agent (drug solution A) and the physiological saline (drug solution B) set in In that case, the operation of the piston drive mechanisms 130a and 130b is controlled so that the contrast agent and the physiological saline solution are released at the set dilution degree, and if the dilution degree exceeds the above reference value, the contrast is performed as described above. The operation of the piston drive mechanisms 130a and 130b can be controlled so that the agent and the physiological saline are released in equal amounts. Alternatively, conversely, as a result of comparing the set dilution degree with the reference value, when the dilution degree is less than the reference value, the piston drive mechanism 130a, so that the contrast medium and the physiological saline are released in equal amounts. The operation of 130b is controlled, and when the dilution degree exceeds the reference value, the operation of the piston drive mechanisms 130a and 130b is controlled so that the contrast medium and the physiological saline are released at the set dilution degree. You may.

The reference value can be set, for example, as a ratio of the amount of the contrast medium to the total amount of the contrast medium and the physiological saline, and the specific value thereof can be, for example, 50%. It should be noted that this value may be arbitrarily changed by the operator or depending on the type of contrast medium used and the like.

The same can be said not only for the degree of dilution but also for the release rate of each chemical solution in the purge operation.

If the release rate of each chemical solution is too slow or too fast, air bubbles may remain in the extracorporeal circuit. Therefore, when the reference range of the discharge rate in the purge operation is preset in the injection control unit 101 and the value of the injection rate set as one of the injection conditions deviates from this reference range, the discharge in the purge operation is performed. It is preferable that the speed is set to the lower limit value or the upper limit value of the reference range. The reference range of the release rate can be, for example, 1.5 (mL / sec) to 2.5 (mL / sec).

(Purge condition setting independent of injection condition setting)
In the above-described form, the release conditions of the drug solution (release rate, release amount, dilution degree, etc.) in the purge operation are set in association with the injection conditions of the drug solution. However, the release field right in the purge operation may be set independently of the injection conditions.

For example, on the injection condition setting screen 400 shown in FIG. 5, a purge setting icon (not shown) is displayed in addition to the various icons described above, and when the purge setting icon is tapped, the injection control unit 101 can be pressed. For example, a screen for accepting the input of the degree of dilution, such as the dilution ratio input screen 430 shown in FIG. 6 or the dilution ratio display screen 440 shown in FIG. 8A, is displayed. The screen for accepting the input of the degree of dilution may be popped up on the injection condition setting screen 400, or may be displayed by being switched to the injection condition setting screen 400. Then, the injection control unit 101 sets the degree of dilution according to the data input from these screens. When the degree of dilution is set, the injection control unit 101 erases the display of the screen for receiving the input of the degree of dilution from the injection condition setting screen 400 or displays the display screen according to the display form. Return to the injection condition setting screen 400. Note that this display may be changed after the purging operation is completed. The total release amount and release rate of the chemical solution A and the chemical solution B in the purge operation may be preset in the injection control unit 101, or an appropriate data input icon (not shown) is displayed to input the data. It is also possible to set according to the data input by the operator from the icon. The data input icon may be, for example, the speed setting icon 404 and the injection amount setting icon 405 shown in FIG.

After the purge conditions such as the degree of dilution, the release rate and the release amount are set, the injection control unit 101 executes the purge operation triggered by a predetermined operation by the operator such as pressing the purge button 123 (see FIG. 3). After that, in the same manner as described above, the injection conditions of the chemical solution are set according to the data input by the operator, and the injection operation of the chemical solution is executed.

(Container and drive mechanism)
In the above-described embodiment, the case where the container filled with the chemical solution is a syringe has been described as an example. However, in the present invention, the container is not limited to the syringe, and may be a chemical solution bottle, a chemical solution bag, or the like. In that case, as the drive mechanism for discharging the chemical solution from the container, a drive mechanism according to the form of the container, such as a tube pump type drive mechanism, can be used.

(Arrangement of units, etc.)
In the above-described embodiment, as shown in FIG. 1, the injection control unit 101 is included in the chemical injection device 100, and the imaging control unit 510 is included in the fluoroscopic imaging device 500. However, both the injection control unit 101 and the imaging control unit 510 may be included in the chemical injection device 100, or both the injection control unit 101 and the imaging control unit 510 may be included in the fluoroscopic imaging device 500. Alternatively, both the injection control unit 101 and the imaging control unit 510 may be included in a programmable computer device (not shown) separate from the chemical injection device 100 and the fluoroscopic imaging device 500. By doing so, it is not necessary for the chemical injection device 100 and the fluoroscopic imaging device 500 to have separate consoles, and the input unit and the display unit of each control unit can be shared. As a result, the configuration of the entire system can be simplified.

Furthermore, a particular function of the injection control unit 101 can be incorporated into a unit separate from the rest of the other functions. For example, the injection condition determination (calculation) function can be incorporated into the imaging control unit 510, and the remaining other functions can be incorporated into the injection control unit 101. In this case, it is not necessary to input data and the like common to the determination of the imaging condition and the determination of the injection condition to the chemical injection device 100 and the fluoroscopic imaging device 500 in duplicate. Data that is insufficient when determining the injection conditions may be input from the imaging control unit 510, or may be transmitted from the injection control unit 101 to the imaging control unit 510.

The functions of the injection control unit 101 and the functions of the imaging control unit 510 can be realized by using various hardware if necessary, but the main body thereof is realized by the function of the CPU corresponding to the computer program.

The computer program is at least part of the procedure described above, eg,
A step of accepting an input of the degree of dilution of the chemical solution discharged from the first syringe (container) by the chemical solution discharged from the second syringe (container), and
A step of setting the discharge conditions of the drug solution from the first and second syringes (containers) in the purging operation performed prior to the injection of the drug solution, using at least the input dilution degree, and
A step of performing the purging operation by controlling the operation of the first and second (piston) drive mechanisms included in the chemical injection device according to the set release conditions, and
Can be implemented as a computer program for causing a chemical injection device 100, a fluoroscopic imaging device 500, or a fluoroscopic imaging system including the chemical injection device 100 and the fluoroscopic imaging device 500 to execute the above.

Further, from a structural point of view, the injection head 110 and the console 112 shown in FIG. 2 can be integrally configured. If the injection head 110 and the console 112 are integrally configured, the console 112 will also be placed in the laboratory. Since the hand switch 118 can be used to start and stop the injection operation, the operator can control the start and stop of the injection operation in the operation chamber by the hand switch 118.

Further, in the above-described embodiment, the two piston drive mechanisms 130a and 130b are mounted on the common injection head 110. However, the chemical injection device has two injection heads each equipped with one piston drive mechanism, and the injection control unit 101 interlocks the injection heads with each other to dilute a plurality of chemical solutions during the purging operation and the injection. You can also do it.

(Other configurations that the chemical injection device can provide)
(I) Load cell The chemical injection device 100 may further have a load cell for detecting the injection pressure. The load cell can be provided, for example, in the presser 131 (see FIG. 3). When a plurality of pressers 131 are provided as shown in FIG. 3, at least one of them may have a load cell. The injection pressure can also be detected by measuring the current of the motor that is the drive source of the piston drive mechanisms 130a and 130b. When the load acting on the presser 131 increases, the motor current increases according to the load. This is used to detect the injection pressure using the motor current. The injection pressure may be detected by either one of the detection using the load cell and the detection using the motor current, or both may be used in combination. When both are used in combination, the injection pressure is usually detected by the load cell, and the injection pressure can be measured by using the measurement result of the motor current only when the load cell fails.

(Ii) RFID module As shown in FIG. 9, the chemical injection device 100 can further include an RFID module 166. Currently, some containers 350 containing chemicals, such as syringes and chemical bottles, are provided with an RFID tag 352, which is a data carrier in which information on the contained chemicals is recorded. The RFID tag 352 usually records information about the contained chemicals. The RFID module 166 is for reading data from the RFID tag 352 and / or for recording data on the RFID tag 352. When the chemical injection device 100 includes the RFID module 166, the data recorded on the RFID tag 352 can be used to control the operation of the chemical injection device 100 by the injection control unit 101. In FIG. 9, the same components as those shown in FIG. 1 are designated by the same reference numerals as those in FIG. 1, and the description thereof will be omitted here.

The RFID module 166 has an RFID control circuit 164 and an antenna 165, reads data recorded on the RFID tag 352 by the antenna 165, transmits the read data to the injection control unit 101, and / or the injection control unit. It is configured so that the data transmitted from 101 can be recorded on the RFID tag 352. The RFID control circuit 164 controls the data transmission / reception operation in the RFID module 166. That is, the RFID module 166 functions as a reader that reads data from the RFID tag 352, or further, a reader / writer that records data on the RFID tag.

Further, at least the antenna 165 of the RFID module 166 is built in the injection head 110 (see FIG. 2), and data is automatically collected from the RFID tag 352 by appropriately attaching the container 350 containing the chemical solution to the injection head 110. Data may be read from the RFID tag 352 by using a handy type unit separate from the injection head 110, for example, and the operator bringing the unit and the RFID tag 352 relatively close to each other. You may do so.

The data recorded on the RFID tag 352 includes various data related to the chemical solution contained in the container 350, for example, the manufacturer, the type of the chemical solution, the product number, the contained component (particularly, when the chemical solution is a contrast medium, the iodine content concentration, etc.) ), The amount of chemicals contained, lot number, expiration date, etc. When the container 350 is a syringe 220, various data related to the syringe 220, such as a unique identification number such as a manufacturer and a product number, an allowable pressure value, a syringe capacity, a piston stroke, required dimensions of each part, a lot number, etc. Can be included. At least a part of these data can be transmitted to the fluoroscopic imaging apparatus 500.

(Other forms of extension tube)
The extension tube is preferably equipped with a mixing device that allows the contrast agent and saline to be mixed well. An example of an extension tube with a mixing device will be described with reference to FIGS. 10A, 10B and 10C.

This extension tube includes a first tube 231a for connecting a syringe filled with a contrast medium and a mixing device 241 and a second tube 231b for connecting a syringe filled with physiological saline and a mixing device 241. It has a third tube 231c that is connected to the liquid outlet (details below) of the mixing device 241 and extends towards the patient. Although not particularly limited, the first and second tubes 231a and 231b may be connected to the conduit portion of the syringe via the connectors 239a and 239b, respectively. Similarly, the third tube 231c may also be connected to a catheter or the like via the connector 239c. At least one of the connectors 239a and 239b connected to the first tube 231a and the second tube 231b may be provided with a one-sided valve, as in the case of the extension tube 300 shown in FIG. At least one may have a release function.

Hereinafter, the mixing device 241 will be described in detail. As shown in FIGS. 10A and 10B, the mixing device 241 has a first chamber which is a swirling flow generation chamber 242a for generating a swirling flow and a second chamber which is a constriction chamber 242b for concentrating the swirling flow in the axial direction. The main body portion 242 is provided. In this example, the swirl flow generation chamber 242a has a columnar internal space, and the constriction chamber 242b has a conical internal space coaxial with the swirl flow generation chamber 242a. The cross-sectional shape of the swirling flow generation chamber in the lateral direction can be considered to be various shapes formed from a circle, an ellipse, or another curve. Further, the swirling flow generation chamber can be configured to have a stenotic shape in which the tip narrows as it approaches the stenotic chamber.

A conduit portion 243a to which the first tube 231a is connected is provided on the upstream side of the flow of the main body portion 242 of the mixing device 241, and a conduit portion 243c to which the third tube 231c is connected is provided on the downstream side. .. The conduit portion 243b to which the second tube 231b is connected is arranged at a position upstream from the center of the swirl flow generation chamber 242a (details below).

In this example, the contrast medium flows in from the conduit portion 243a and the physiological saline solution flows in from the conduit portion 243b, and both drug solutions are mixed in the mixing device. After that, the mixed drug solution of the contrast medium and the physiological saline flows out from the conduit portion 243c as the liquid outlet.

The conduit portion 243a into which the chemical liquid having a large specific gravity flows is provided in the central portion of the upstream side wall surface of the swirling flow generation chamber 242a on the upstream side in the flow direction. The conduit portion 243c, which is a liquid outlet, is provided so that the center line of the conduit portion 243c and the center line of the conduit portion 243a coincide with each other, that is, both of them are coaxial. By arranging each part so as to have a common axis, the isotropic property of the vortex generated in the mixing device can be enhanced. That is, the vortex can be generated uniformly in the space without stagnation, and the mixing efficiency can be improved.

On the other hand, the conduit portion 243b into which the chemical solution having a small specific gravity flows is arranged on the side surface of the swirl flow generation chamber 242a and extends in the tangential direction of the circumference of the swirl flow generation chamber 242a having a circular cross section. In other words, the conduit portion 243b is provided at a position deviated from the central axis of the columnar space of the swirl flow generation chamber 242a toward the peripheral edge side, whereby the chemical liquid having a small specific gravity flowing from the conduit portion 243b is provided. The swirling flow of is generated. More specifically, as shown in FIG. 10C, the flow path 241fb is configured to extend in the circumferential tangential direction of the curved inner surface of the swirl flow generation chamber 242a, thereby flowing in from this flow path. The chemical solution becomes a swirling flow. Further, as is clear from the drawing, the constriction chamber 242b has an inclined inner surface that narrows toward the downstream side in the flow direction, so that the generated swirling flow is concentrated in the central axis direction of the vortex. Become.

Further, the conduit portion 243a into which the contrast medium flows is communicated with the swirling flow generation chamber 242a via the flow path 241fa. Thereby, the chemical solution having a large specific gravity can be introduced into the swirling flow generation chamber in the direction parallel to the central axis of the swirling flow of the chemical solution having a small specific gravity. That is, the chemical solution having a large specific gravity is introduced in the direction parallel to the central axis of the columnar space of the swirling flow generation chamber. Further, the conduit portion into which the physiological saline solution flows is communicated with the swirling flow generation chamber via the flow path 241fb. As an example, the inner diameter of the flow path 241fb may be formed smaller than the inner diameter of the flow path 241fa into which the contrast medium flows. According to such a configuration, when the chemical solution is injected at a predetermined pressure, the flow velocity of the chemical solution having a small specific gravity flowing in from the flow path 241fb having a relatively small cross-sectional area becomes faster than the flow velocity of the chemical solution having a large specific gravity. Therefore, it is possible to avoid a decrease in mixing efficiency between the chemicals due to the attenuation of the inertial force of the swirling flow and the resulting lack of swirling strength, which may occur when the flow velocity of the chemicals having a small specific gravity is slow.

In the mixing device 241 configured as described above, for example, when the contrast medium and the physiological saline flow into the device, the contrast medium flowing into the swirling flow generation chamber from the flow path 241fa flows toward the downstream side in the axial direction. Become. On the other hand, the physiological saline flowing into the swirling flow generation chamber from the flow path 241fb becomes a swirling flow that swirls along the curved inner surface of the chamber, and the swirling flow of the physiological saline is guided to the constriction chamber and swirls. Concentrate in the direction of the central axis of the flow. Such a vortex is known as a Rankine vortex, and the inertial force of the swirling flow can be concentrated in the vicinity of the rotation axis of the vortex.

Then, when two chemical solutions are simultaneously injected through an extension tube having such a mixing device 241, both chemical solutions are well mixed. That is, in this example, a diluted contrast medium in which the contrast medium and physiological saline are well mixed can be obtained, and as a result, unevenness in the concentration of the contrast medium is eliminated, so that a general T-shaped connector is provided. An excellent contrast effect can be expected as compared with the case of the extension tube.

(Collaboration with medical network)
At least the drug solution injection device 100 and the fluoroscopic imaging device 500 may be connected to the medical network. As a result, the injection rate, injection time, and injection amount of the drug solution injected by the drug solution injection device 100 (if multiple injections are performed in one examination and / or treatment, the injection amount for each injection). And the total injection volume of a series of injections), the injection graph, the type of drug solution injected, the injection results including the dilution ratio when dilution injection was performed, and the imaging conditions by the fluoroscopic imaging device 500 are available through the medical network. It can be stored as injection data in a fluoroscopic imaging device, RIS (radiological information system), PACS (medical image storage management system), HIS (hospital information system), or the like. As a result, the saved injection data is used for managing the injection history. In particular, the injection amount can be recorded in medical record information as a used chemical solution or used for accounting processing. It is also possible to acquire physical information such as the body weight of the subject, ID, name, examination site, and examination method from RIS, PACS, HIS, etc., display them on the drug solution injection device, and perform injection according to the information. This information may be transmitted from the chemical injection device 100 to RIS, PACKS, HIS, etc. via the fluoroscopic imaging device 500, or may be directly transmitted from the chemical liquid injection device 100 to RIS, PACKS, HIS, etc. Good. When the chemical injection device 100 includes the RFID module 166, the data transmitted to the RIS, PACKS, HIS, etc. can include the data acquired from the RFID tag 352 by the RFID module 166.

100 Chemical injection device 101 Injection control unit 110 Injection head 112 Console 114 Main unit 120 Syringe receiver 123 Purge button 130a, 130b Piston drive mechanism 131 Presser 140 Clamper 164 RFID control circuit 165 Antenna 166 RFID module 200 Syringe assembly 220 Syringe 270 Protective cover 300 Extension tube 301 1st tube 302 2nd tube 303 3rd tube 304 T-shaped connector 350 container 352 RFID tag 400 Injection condition setting screen 500 Perspective imaging device 510 Imaging control unit 520 Imaging operation unit

Claims (28)

A chemical injection device that injects the chemical solution filled in the container.
A first drive mechanism configured to discharge the drug solution from the first container,
A second drive mechanism configured to discharge the drug solution from the second container,
At least an injection device control unit that controls the operation of the first drive mechanism and the second drive mechanism,
Have,
The injection device control unit receives an input of the degree of dilution of the chemical solution discharged from the first container by the chemical solution discharged from the second container, and uses at least the input degree of dilution to make the chemical solution. The discharge conditions of the chemical solution from the first and second containers in the purge operation performed prior to the injection of the drug solution are set, and the operation of the first and second drive mechanisms is controlled according to the set discharge conditions. A chemical injection device that is configured. The injection device control unit further accepts the input of data for setting the injection condition in the injection of the drug solution, sets the injection condition based on the input data, and inputs the dilution degree to the injection condition setting. The chemical injection device according to claim 1, which accepts an input of the degree of dilution each time it is changed. The injection condition includes the degree of dilution of the chemical solution discharged from the first container with the chemical solution released from the second container, and the injection device control unit sets the degree of dilution set as the injection condition. The chemical injection device according to claim 2, which is used as the degree of dilution during the purging operation. The injection condition further includes the total injection rate of the drug solution discharged from the first container and the drug solution discharged from the second container, and the injection device control unit further includes the dilution degree and the total injection. The chemical solution injection device according to claim 3, wherein the discharge rate of the chemical solution from the first container and the release rate of the chemical solution from the second container in the purge operation are calculated from the velocity. The chemical injection device according to claim 2, wherein the injection device control unit receives an input of the dilution degree in the purge operation in addition to the input of data for setting the injection conditions. In the purge operation, the purge amount, which is the total amount of the chemicals discharged from the first container and the second container, is set in the injection device control unit, and the injection device control unit determines the degree of dilution. The chemical solution according to any one of claims 1 to 5, which calculates the amount of the chemical solution released from the container 1 and the amount of the chemical solution released from the second container from the purge amount. Injection device. At the start of the purging operation, the injection device control unit discharges the drug solution from at least one of the first container and the second container at the same discharge rate or different discharge rates from each other, and then the purging operation is performed. At least a part of the time until the end, the release rate of the drug solution from at least one of the first container and the second container is changed so that the final dilution becomes the desired dilution. The drug solution injection device according to any one of claims 1 to 6, which sets the release conditions. The chemical injection device according to claim 7, wherein the injection device control unit sets the discharge conditions so that the chemical solution is discharged from the first and second containers at the same discharge rate at the start of the purge operation. The injection device control unit discharges the chemical solution from only one of the first and second containers at the start of the purging operation, and then releases the chemical solution from the one container until the end of the purging operation. The drug solution injection device according to claim 7, wherein the release conditions are set so as to decrease the rate and increase the release rate of the drug solution from the other container. The injection device control unit changes the discharge rate of the chemical solution so that the dilution degree becomes the desired dilution degree before the end of the purge operation, and thereafter, the release rate of the chemical solution is maintained until the end of the purge operation. The drug solution injection device according to any one of claims 7 to 9, wherein the release conditions are set as described above. When the reference value of the dilution degree is preset in the injection device control unit, and the input degree of dilution is equal to or less than the reference value, the injection device control unit performs the first container in the purge operation. The chemical injection device according to any one of claims 1 to 10, wherein the operation of the first and second drive mechanisms is controlled so that the chemical liquid is discharged in equal amounts from the second container. When the reference value of the degree of dilution is set in advance in the injection device control unit, and the input degree of dilution exceeds the reference value, the injection device control unit performs the first container in the purge operation. The chemical injection device according to any one of claims 1 to 10, wherein the operation of the first and second drive mechanisms is controlled so that the chemical liquid is discharged in equal amounts from the second container. It further comprises at least one input interface that accepts at least the dilution degree input and at least one display unit.
The chemical injection device according to any one of claims 1 to 12, wherein the injection device control unit displays the degree of dilution input from the input interface on the display unit. The chemical injection device according to any one of claims 1 to 13, wherein the injection device control unit operates the first drive mechanism and the second drive mechanism at the same time and for the same time in the purge operation. .. The chemical injection device according to any one of claims 1 to 14, further comprising a single injection head equipped with the first drive mechanism and the second drive mechanism. The drug solution injection device according to any one of claims 1 to 14, further comprising a first injection head equipped with the first drive mechanism and a second injection head equipped with the second drive mechanism. The drug solution injection device according to any one of claims 1 to 16.
A first container and a second container that are detachably attached to the chemical injection device,
An injection circuit connected to the first container and the second container,
Chemical injection system with. The drug solution injection system according to claim 17, wherein at least one of the first container and the second container is a container filled with a contrast medium. The drug solution injection system according to claim 17 or 18, wherein the injection circuit includes an extracorporeal circuit portion branched so that the terminal side is connected to the first container and the second container. The drug solution injection system according to any one of claims 17 to 19.
A fluoroscopic imaging device that acquires a medical image from a subject who has been injected with a drug solution by the drug solution injection system.
Fluoroscopic imaging system. The fluoroscopic imaging system according to claim 20, wherein the fluoroscopic imaging device is an angiography apparatus. A chemical solution having a first container and a second container detachably attached and having a first drive mechanism for discharging the drug solution from the first container and a second drive mechanism for discharging the drug solution from the second container. It is a method of operating the injection device,
A step of accepting an input of the degree of dilution of the chemical solution from the first container with the chemical solution from the second container, and
Using at least the input degree of dilution, a step of setting the discharge conditions of the chemical solution from the first and second containers in the purge operation performed prior to the injection of the chemical solution, and
The step of performing the purging operation by controlling the operation of the first and second piston drive mechanisms according to the set release conditions, and
How to operate the chemical injection device having. A step of setting the injection condition of the chemical solution, which comprises accepting an input of the degree of dilution between the chemical solution discharged from the first container and the chemical solution discharged from the second container. Has more steps to set,
The method of operating a chemical injection device according to claim 22, wherein the step of setting the release condition includes using the dilution degree input as the injection condition as the dilution degree at the time of the purging operation. It further includes a step of accepting input of data for setting the injection condition in the injection of the drug solution, and a step of setting the injection condition based on the input data.
The operation of the chemical injection device according to claim 22, wherein the step of accepting the input of the dilution degree includes accepting the input of the dilution degree in the purging operation separately from the input of the data for setting the injection condition. Method. In the purging operation, the purging amount, which is the total amount of the chemicals discharged from the first container and the second container, is preset.
In the step of setting the release conditions, the amount of the drug solution released from the first container and the amount of the drug solution released from the second container in the purge operation are calculated from the degree of dilution and the purge amount. The method for operating a chemical injection device according to any one of claims 22 to 24. In the step of setting the release conditions, the chemical solution is discharged from the first and second containers at the same discharge rate at the start of the purge operation, and then the first container and the first container and the first container and the second container are released until the end of the purge operation. 22. 25 of claims 22 to 25, which comprises varying the release rate of the drug solution from at least one of the second containers and setting the release conditions so that the final dilution is the desired dilution. How to operate the chemical injection device. The reference value of the degree of dilution is set in advance,
In the step of performing the purging operation, when the input degree of dilution is equal to or less than the reference value, the chemical solution is discharged in equal amounts from the first container and the second container in the purging operation. The method for operating a chemical injection device according to any one of claims 22 to 26, which comprises controlling the operation of the first and second drive mechanisms. The reference value of the degree of dilution is set in advance,
In the step of performing the purging operation, when the input degree of dilution exceeds the reference value, the chemical solution is discharged in equal amounts from the first container and the second container in the purging operation. The method for operating a chemical injection device according to any one of claims 22 to 26, which comprises controlling the operation of the first and second drive mechanisms.

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