JP6781992B2 - Experimental data recording device, computer program, experimental data, experimental data recording method, experimental data display device and experimental data display method - Google Patents

Description

The present invention relates to an experimental data recording device, a computer program, experimental data, an experimental data recording method, an experimental data display device, and an experimental data display method.

In order to correctly evaluate the results of experiments in fields such as biochemistry and biology / biotechnology (meaning operations on samples such as a series of tests, culture, and amplification), the experiments must be performed under preset procedures and conditions. It needs to be verifiable that it is being done on the street. The work procedure and conditions in an experiment are generally called a protocol, and whether or not an experiment was performed correctly according to the protocol will be judged by the experimenter depending on the description in his / her own experiment notebook. ..

An object to be solved by the present invention is to record a record of an experiment based on a protocol objectively and with high reliability.

The experimental data recording device according to one aspect of the present invention is an experimental data recording device that records experimental data that is a record of experiments based on a protocol in at least one of the fields of biochemistry and biological / bioengineering, and is an experimental data recording device. The protocol includes a receiving unit that receives an operation record, an experiment ID recording unit that records an experiment ID that is an experiment-specific ID in association with a protocol-specific protocol ID, and the received operation record. It has an operation recording / recording unit for recording in association with a corresponding procedure among a plurality of procedures.

Further, the experimental data recording device according to one aspect of the present invention further includes a target sample ID recording unit that records a target sample ID, which is an ID of a sample that is the subject of an experiment, in association with the experiment ID, and an experiment. The result sample ID recording unit, which records the result sample ID, which is the ID of the sample obtained as a result of the above, in association with the experiment ID, may be provided.

Further, the experimental data recording device according to one aspect of the present invention may further have an experimental environment data recording unit that records experimental environment data in association with the experiment ID.

Further, in the experimental data recording device according to one aspect of the present invention, the experimental instrument may include an instrument directly operated by the experimenter.

Further, in the experimental data recording device according to one aspect of the present invention, the experimental instrument may include an electric pipette.

In addition, the experimental data recording device according to one aspect of the present invention may further have an in-experiment protocol display unit that displays the protocol related to the experiment on a monitor during the experiment.

Further, in the experimental data recording device according to one aspect of the present invention, the experimental instrument may include a robot that executes an experiment based on the protocol.

Further, the experiment data recording device according to one aspect of the present invention may further have an experiment ID issuing unit that issues the experiment ID for each experiment.

Further, in the experiment data recording device according to one aspect of the present invention, the experiment ID issuing unit may acquire an experiment ID generated by an external experiment ID generating device.

Further, the experimental data recording device according to one aspect of the present invention may further have a falsification prevention unit that performs falsification prevention processing on the experimental data.

Further, in the experimental data recording device according to one aspect of the present invention, the falsification prevention unit may perform falsification prevention processing at least every time the operation recording is recorded by the operation recording recording unit.

Further, the experimental data recording device according to one aspect of the present invention may further have an experimental data storage unit for storing the obtained experimental data in an external experimental data storage device.

Further, the experimental data recording device according to one aspect of the present invention further records analytical data that is associated with the result sample ID of the sample, which is the data of the analysis result for the sample obtained as a result of the experiment. May have a part.

Further, the experimental data recording device according to one aspect of the present invention further corresponds to the protocol by associating the post-experiment protocol display unit for displaying the protocol in which the experiment was performed and the procedure included in the protocol. It may have an operation record display unit for displaying the operation record included in the experimental data.

In addition, the computer program according to another aspect of the present invention causes the computer to function as any of the above-mentioned experimental data recording devices.

Further, the experimental data according to another aspect of the present invention is experimental data which is a record of an experiment based on a protocol in at least one field of biochemistry and biological / bioengineering, and is associated with a protocol ID peculiar to the protocol. It includes an attached experiment ID, which is an experiment-specific ID, and an operation record of the laboratory equipment associated with the corresponding procedure included in the protocol.

Further, the experimental data recording method according to another aspect of the present invention is an experimental data recording method for recording experimental data which is a record of an experiment based on a protocol in at least one field of biochemistry and biological / bioengineering. , Receives the operation record of the experimental instrument, records the experiment ID which is the ID unique to the experiment in association with the protocol ID unique to the protocol, and records each of the received operation records in the plurality of procedures included in the protocol. Of these, record it in association with the corresponding procedure.

Further, the experimental data display device according to another aspect of the present invention displays the protocol in which the experiment was performed with respect to the experimental data which is a record of the experiment based on the protocol in at least one field of biochemistry and biological / bioengineering. It has a post-experiment protocol display unit and an operation record display unit that displays the operation record used in the experiment, which is included in the experiment data corresponding to the protocol, in association with each of the procedures included in the protocol. ..

Further, the experimental data display device according to one aspect of the present invention may further have an analysis data display unit that displays analysis data corresponding to the experiment data.

Further, the experimental data display method according to another aspect of the present invention displays the protocol in which the experiment was performed with respect to the experimental data which is a record of the experiment based on the protocol in at least one field of biochemistry and biological / bioengineering. Then, in association with each of the procedures included in the protocol, the operation record of the experimental equipment used in the experiment included in the experimental data corresponding to the protocol is displayed.

It is a block diagram which shows the physical structure of the experimental data recording apparatus which concerns on embodiment of this invention. It is a functional block diagram of the experimental data recording apparatus which concerns on embodiment of this invention. It is a figure which shows an example of a protocol. It is a conceptual diagram which shows the whole experiment system including the experiment data recording apparatus. It is a figure which shows an example of how experimental data is superimposed and displayed on the protocol chart. It is a flow chart which shows the operation which the experiment data recording apparatus records an experiment data. It is a flow chart which shows the operation which the experiment data recording apparatus superimposes and displays the experiment data on a protocol chart. It is a functional block diagram of the experimental data recording apparatus which concerns on the modification of embodiment of this invention. It is a functional block diagram of an experiment data display device.

From the point of view of the inventor of the present invention, there is room for subjective and human error by the experimenter to intervene in the record of the experiment by the experiment notebook, and it takes a lot of time to verify the result for the important experiment. And labor may be required. In addition, requesting accurate and sufficient records in the experiment notebook imposes a burden on the experimenter, and may reduce the work efficiency of the experiment and the productivity of the research activity itself.

Therefore, the inventor of the present invention has invented a new and original experimental data recording device and the like as a result of diligent research and development on recording experiments based on a protocol with objectivity and high reliability. I came to do it. Hereinafter, such an experimental data recording device and the like will be described in detail through the embodiment with reference to the drawings.

FIG. 1 is a block diagram showing a physical configuration of the experimental data recording device 1 according to the embodiment of the present invention. The experiment data recording device 1 itself may be a dedicated device, but here, it is realized by using a general computer. That is, in a commercially available computer, such a computer is used as the experimental data recording device 1 by executing a computer program that operates the computer as the experimental data recording device 1. Such computer programs are generally provided in the form of application software and are installed and used on a computer. The application software may be recorded and provided on an appropriate computer-readable information recording medium such as a CD-ROM or DVD-ROM, or may be provided through various information communication networks such as the Internet. Alternatively, it may be realized by so-called cloud computing in which the function is provided by a server located at a remote location through an information communication network.

The configuration shown in FIG. 1 shows a general computer used as an experimental data recording device 1, and includes a CPU (Central Processing Unit) 1a, a RAM (Random Access Memory) 1b, an external storage device 1c, and a GC (Graphics Controller). ) 1d, the input device 1e and the I / O (Input / Output) 1f are connected by the data bus 1g so that electric signals can be exchanged with each other. Here, the external storage device 1c is a device such as an HDD (Hard Disk Drive) or an SSD (Solid State Drive) that can statically record information. Further, the signal from the GC1d is output to a monitor 1h such as a flat panel display on which the user visually recognizes the image, and is displayed as an image. The input device 1e is a device such as a keyboard, a mouse, and a touch panel for the user to input information, and the I / O 1f is an interface for the experimental data recording device 1 to exchange information with an external device.

FIG. 2 is a functional block diagram of the experimental data recording device 1 according to the present embodiment. The functional blocks shown here are shown focusing on the functions of the experimental data recording device 1, and do not necessarily have a one-to-one physical configuration in each functional block. Some functional blocks are realized by an information processing device such as CPU 1a of the experimental data recording device 1 executing specific software, and some functional blocks are specific to an information storage device such as RAM 1b of the experimental data recording device 1. This is achieved by allocating storage space.

The experimental data recording device 1 has a protocol data storage unit 10 for storing protocol data which is electronic data indicating a protocol and an experimental data storage unit 11 for storing experimental data, and can store experimental data obtained at the time of an experiment. , Recorded in association with protocol data indicating the protocol on which the experiment was based. Here, the protocol refers to work procedures and conditions such as pretreatment performed on a sample in fields such as biochemistry and biology / biotechnology, and the individual procedures included in the protocol are described in the specified conditions and order. It is described that a predetermined experiment is performed by performing in. In addition, the protocol usually includes experiments in fields such as biochemistry or biology / biotechnology (not limited to experiments in a narrow sense, but also includes performing a predetermined treatment on a sample, a reagent, a sample, etc. by a specific procedure, and is produced or manufactured. It is described for the practitioner or planner of (including acts, etc.) to carry out the experiment as planned and to record and convey the contents of the experiment. Therefore, as described above, the protocol referred to here is not limited to a specific description format, including one or more work procedures and the like. Further, since the number, quality, contents, etc. of the work procedures included in the protocol depend on the intention of the protocol creator, these are also not limited. Furthermore, the technical field in which the protocol referred to here is used is not limited to biochemistry or biotechnology / biotechnology, but the present specification includes at least one of biochemistry and biotechnology / biotechnology. And. The protocol data includes a protocol ID that is information that uniquely identifies the protocol, and procedure data that means individual procedures included in the protocol. In addition, the experimental data refers to various information related to the experiment such as the experiment itself, various conditions of the experiment, and operation records of various instruments used in the experiment in the experiment based on the protocol. In particular, the experimental data includes an experiment ID, which is information that uniquely identifies the experiment itself, and operation records of various instruments used in the experiment.

The protocol data storage unit 10, the protocol server 32 described later, or both of them may store one or more protocol data associated with the protocol ID, and the protocol data can be specified from the protocol ID. It may have a function similar to a general database, such as being able to do so.

The experiment data recording device 1 includes various recording units that record various information contained in the experiment data at the time of the experiment. When conducting an experiment, the experiment ID recording unit 12 associates the experiment ID with the protocol ID and records it in the experiment data storage unit 11 as experimental data. Specifically, this association means that the experiment specified by the experiment ID was performed based on the protocol specified by the protocol ID by including both the protocol ID and the experiment ID in the experiment data. Shown. The protocol data itself may be added to the experimental data. The experiment ID is issued by the experiment ID issuing unit 13 for each experiment.

The experiment data storage unit 11, the experiment data storage device 26 described later, or both of them may also store one or more experiment data associated with the protocol ID and the experiment ID, and the experiment is performed from the experiment ID. It may have a function similar to a general database, such as being able to specify data and searching for experimental data from a protocol ID.

The experiment ID issuing unit 13 may generate the experiment ID by itself, but acquires the experiment ID generated by the external experiment ID generating device 24 connected via the communication unit 20. You may. By installing the experiment ID generator 24 in common in a plurality of experiment data recording devices 1 as a web server capable of communicating via a telecommunication line such as the Internet, there is no duplication in different experiment data recording devices 1. , The experiment ID can be uniquely issued. Alternatively, the experiment ID issued by the experiment ID issuing unit 13 may be restricted in some way, for example, by using an ID uniquely set for the experiment data recording device 1 as a part of the experiment ID. Uniqueness may be guaranteed. In any case, the experiment ID is issued as a unique one for each experiment, and various information contained in the experiment data described below is recorded in association with this experiment ID. Therefore, which experiment contains these various information. It will be clearly recorded whether it is information about.

The experimental environment data recording unit 14 records the experimental environment data for the experiment as experimental data in the experimental data storage unit 11. The experimental environment data is data indicating conditions for the experiment itself, and includes at least one of data indicating the experimenter, the experimental location, the date and time of the experiment, and the experimental equipment. The experimenter is information that identifies the person who directly conducted the experiment or the person responsible for the experiment, the experiment location is information that identifies the location of the building, room, booth number, etc. where the experiment was conducted, and the date and time of the experiment is It is information for specifying the date and time when the experiment was performed, and may include the start time of the experiment and the end time in addition to the start time. The data indicating the laboratory equipment is information for identifying the laboratory equipment used in the experiment. For example, as will be described later, when the laboratory equipment is an electric pipette, a unique ID such as a serial number of the electric pipette corresponds to information for identifying the laboratory equipment. When a plurality of laboratory equipments are used, for example, when a plurality of electric pipettes are used, or when a microscope is used in addition to the electric pipettes, all the IDs unique to each laboratory equipment are used as data indicating the laboratory equipment. It may be included in the experimental environment data. Experimental environment data can also be used as important data to show that the experiment was conducted in a genuine manner.

The target sample ID recording unit 15 records the target sample ID, which is information for identifying the sample used in the experiment, as experimental data in the experimental data storage unit 11. In addition, the result sample ID recording unit 16 stores experimental data using the result sample ID as experimental data, which is information for identifying the sample as the result of the experiment, which is obtained as a result of performing various operations on the sample used in the experiment. Record in section 11. As a result, the target sample used in the experiment and the result sample obtained as a result of the experiment can be accurately identified. As the target sample ID and the result sample ID, for example, an ID indicating a container attached to a container such as a test tube or a Petri dish in which the sample is stored may be read by a reader 17 and used as the target sample ID or the result sample ID. ..

The operation record recording unit 18 records the operation records of various instruments used in the experiment as experimental data in the experimental data storage unit 11. Here, the operation record is a record of the operation of the laboratory equipment 19 used in the experiment, and is received by the receiving unit 21 via the communication unit 20. A specific example of the operation record will be described later. Since the operation record records that each procedure included in the protocol is actually performed using the specific laboratory equipment 19, the operation record recording unit 18 records each of the operation records in the protocol. Record in association with the corresponding procedure data in the data. Thereby, it is possible to identify which of the plurality of procedures included in the protocol corresponds to each of the operation records included in the experimental data.

The analysis data recording unit 22 records the analysis data, which is the information of the result of analyzing the result sample obtained after the experiment is completed by the external analyzer 23, in the experiment data storage unit 11 as the experiment data. At this time, in order to identify the sample analyzed by the analyzer 23, the analysis data recording unit 22 records the analysis data in association with the result sample ID. In addition to the information on the sample to be analyzed, the analysis data may include information on the analysis environment, for example, an ID that identifies the analyzer used for the analysis, various analysis conditions, and information indicating the analysis date and time. .. As a result, not only the facts of the experiment but also the obtained results can be evaluated by the experimental data. Further, since the result sample ID is associated with the experiment ID, the analysis data is also associated with the experiment ID.

The experiment data storage unit 25 stores the experiment data recorded by the various recording units described above and stored in the experiment data storage unit 11 in the external experiment data storage device 26 via the communication unit 20. When the experiment data storage device 26 is installed as a web server capable of communicating via a telecommunication line such as the Internet, the stored experiment data can be viewed from devices other than the experiment data recording device 1. Yes, and it can be viewed by third parties other than the experimenter. In order to ensure the confidentiality of the experiment data and limit the number of people who can view the experiment data, a password is added to the experiment data stored in the experiment data storage device 26, a viewing restriction is added, and the corresponding viewing authority is given. You may want to restrict viewing to those who have it. Further, in the storage of the experimental data by the experimental data storage unit 25, it is advisable to perform an appropriate falsification prevention process on the experimental data through the falsification prevention unit 33. The falsification prevention unit 33 prevents falsification of electronic data by performing known falsification prevention processing, for example, adding an electronic certificate or adding a hash value by a private hash function to the experimental data. As a result, artificial manipulation is performed on the experimental data, data corruption can be detected, and the reliability and accuracy of the experimental data can be maintained.

The communication unit 20 performs electrical communication between the experimental data recording device 1 and various external devices. The communication unit 20 is realized by the I / O 1f of FIG. 1, and the communication is not limited to wired / wireless or the communication standard used. In particular, the communication unit 20 communicates with the laboratory equipment 19 and causes the receiving unit 21 to receive the operation record thereof.

During the experiment, the protocol display unit 27 displays the protocol used in the experiment on the monitor 1h based on the protocol data stored in the protocol data storage unit 10 during the experiment. As a result, when the experimenter directly operates the laboratory equipment 19 to perform the experiment, the experimenter can perform the operation while confirming the protocol. Examples of the laboratory equipment 19 that such an experimenter should directly operate include an electric pipette and a microscope. Further, when the experimental equipment 19 is a robot and the robot control device interprets the protocol data and automatically performs the experiment, the protocol display unit 27 during the experiment allows the experimenter who witnesses the experiment to include the robot in the protocol. You can check which operation you are performing.

After the experiment, the protocol display unit 28 indicates that the protocol data stored in the protocol data storage unit 10 or the experimental data stored in the experimental data storage unit 11 contains the protocol data for the protocol in which the experiment was performed. , The protocol is displayed on the monitor 1h based on the protocol data. Further, the operation record display unit 29 simultaneously records the operation record on the monitor 1h based on the experimental data stored in the experiment data storage unit 11 in association with each procedure included in the protocol displayed on the monitor 1h. indicate. In this way, by displaying the protocol and the experiment data on the monitor 1h in association with the operation record for each procedure, it is possible to immediately grasp how each procedure included in the experiment was actually performed. it can. Further, the analysis data display unit 30 further displays the analysis data obtained by the external analyzer 23 on the monitor 1h in association with the result sample obtained by the experiment. As a result, the protocol on which the experiment is based, the history of the experiment, and the analytical data obtained as a result of the experiment are shown in association with each other, and since this information is linked to each other, the record of the experiment based on the experiment can be recorded. It will be shown objectively and with high reliability. Further, since this record is automatically recorded by the experiment data recording device 1, it does not impose an extra burden on the experimenter, such as requesting detailed entries in the experiment notebook in order to record the experiment.

FIG. 3 is a diagram showing an example of a protocol displayed on the monitor 1h by the display unit 27 or the protocol display unit 28. As shown here, the protocol is in the form of a chart, which clearly shows each procedure included in the protocol, its execution order and conditions, and the instruments used in the experiment. Hereinafter, the protocol shown in the form of a chart is referred to as a protocol chart. The protocol chart shown in FIG. 3 is a part thereof.

More specifically, in the protocol chart shown in this example, the procedure is shown vertically from top to bottom for each container used to contain the sample used in the experiment and to perform various operations on the sample. The containers used in the experiment are shown side by side, demonstrating that the sequence of procedures along the vertical axis is performed sequentially for one container.

The container is represented by the symbol 100a, which means the initial state of the container, and the symbol 100b, which means the final state of the container, and the flow of the container or the sample contained in the container goes from the container symbol 100a to the container symbol 100b. It is indicated by a vertical arrow. The procedure performed on the container or the sample contained in the container is indicated by the symbol 100c indicating the individual procedure. Here, when the procedure is an operation of removing the contents from the container (for example, "Discard" meaning disposal of the contents), an arrow drawn from the vertical arrow, an operation of adding the contents to the container (for example,). , "Add" which means addition of a reagent, etc.), by the arrow that joins the vertical arrow, or by the operation performed by the container alone (for example, "Scrape" which means scraping of cells, or By arranging the symbol 100c on the vertical arrow, the symbol 100c is displayed in a visually easy-to-understand manner as to what each procedure is like (“Centrifuge” etc., which means centrifugation). Each symbol 100c indicates a condition such as a reagent to be used and a quantity. The execution order of the procedure in the experiment is determined by the placement position of each symbol, that is, the priority from top to bottom, and in the case of symbols of the same height, the priority is from left to right. Therefore, the execution order of each procedure is also uniquely shown.

The protocol data stored in the protocol data storage unit 10 includes a protocol ID uniquely assigned to the protocol as shown in FIG. 3 and procedure data indicating each procedure shown in the protocol. Here, the procedure data is data corresponding to the individual symbols shown in FIG. The protocol display unit 27 during the experiment interprets the protocol data and displays the protocol chart on the monitor 1h in the manner shown in FIG. The protocol chart shown in FIG. 3 is an example, and the protocol may be indicated in a different format as a format for expressing the protocol, but at least the individual procedures included in the protocol are specified independently. ..

FIG. 4 is a conceptual diagram showing the entire experimental system including the experimental data recording device 1. The figure shows how various devices are communicatively connected to a wide area telecommunication line represented by the Internet or the like.

The experimental data recording device 1 shown in the lower left of the figure is connected to an electric pipette, which is an instrument directly operated by the experimenter as an example of the experimental instrument 19, and the experimental data recording device 1 records the experiment performed by the experimenter. It is intended to be recorded in. The protocol data created by the protocol creation device 31 separately prepared (or the experiment data recording device 1 itself may also be used) may be read into the experiment data recording device 1.

The experiment data recording device 1 shown in the lower right of the figure is connected to an automatic device, here a general-purpose robot, as an example of the laboratory equipment 19, and an experiment based on protocol data is executed by automatic control of the robot and recorded. Is intended to be recorded by the experimental data recording device 1. Protocol data stored in the protocol server 32, which is a server connected through a telecommunications line, is downloaded to the experiment data recording device 1, experiments are recorded based on the protocol data, and the robot may be controlled. .. The protocol server 32 may store not only the protocol data created by the experimenter who is the main body of the experiment but also a large number of protocol data created by a third party, whereby the experiment by another researcher can be performed. Effective utilization of the protocol as an intellectual asset can be achieved, such as easy follow-up tests and new experiments using protocols created by other researchers.

In addition, the analyzer 23, the experiment ID generator 24, the experiment data storage device 26, and the like may be connected to the telecommunication line so as to be able to communicate with the experiment data recording device 1. These devices have already been described.

The experimental data collected and recorded by the experimental data recording device 1 through the experimental system shown above is displayed on the monitor 1h of the experimental data recording device 1 on the monitor 1h of the experimental data recording device 1 based on the request from the user and the like. 28, the operation record display unit 29 and the analysis data display unit 30 superimpose and display the protocol chart. FIG. 5 is a diagram showing an example of how the experimental data is superimposed and displayed on the protocol chart.

The point that the protocol display unit 28 displays the protocol chart on the monitor 1h after the experiment is almost the same as that of the protocol display unit 27 during the experiment described above. Here, it is assumed that the same protocol chart as that shown in FIG. 3 is shown, and the same applies to the point that the protocol is shown by various symbols 100.

The operation record display unit 29 displays the operation record included in the experimental data in the vicinity of each symbol on the protocol chart. As a result, the operation record and the procedure included in the protocol are shown in association with each other. In the example shown in FIG. 5, for example, the target sample name (“Sample 1”), the target sample ID (“1400010”), and the time when the sample was prepared are immediately below the symbol 100a on the upper left. For the symbol 100c, the name of the laboratory equipment used (“pipette 4”) and its ID (“450341”), the chip used and its individual number (“chip 4340” and “2689912”), and the liquid were aspirated and discarded. The measured value of the quantity (“627 μL”) and the time when the procedure was executed are shown. Similarly, the symbol 100c below it indicates the ID of the reagent used (“156710”), and the symbol 100c below it indicates the individual number of the scraper used (“156710”) with time. In this way, the operation record display unit 29 displays the operation record of the experimental instrument in association with each procedure, and the operation record includes the used instrument, consumables, reagents, time, and operation amount (quantity and time). ) Etc. are included.

Furthermore, the symbol 100c below it indicates the transfer of the sample between the containers, and as shown by reference numeral 101 here, an image such as a photograph of the actual sample taken during the experiment or during the experiment Physical quantities such as temperature and pH measured and recorded may be shown together as an operation record. By doing so, it is possible to track in detail that the protocol-based experiments were performed, how the individual procedures were performed, and how the samples changed in the process. It will be possible.

In addition, various experimental environment data may be shown together with the experimental ID and the protocol ID, as indicated by reference numeral 102 at the top of the protocol. This also ensures that the circumstances under which the experiment was performed, such as when and by whom the experiment was performed, are also error-free.

Further, the analysis data display unit 30 displays the analysis data on the monitor 1h together with the protocol chart and the experimental data as shown by reference numeral 103. The display format of this analysis data is an example, but this is the analysis data for the sample 1 whose target sample ID is 1400010, the result sample ID which is the analysis target is 9400010, and the analysis result is based on some standard. It is shown that the judgment (eg, reliable experimental result, etc.) was OK. In addition, although "LOG" is displayed on the upper right of the displayed analysis data, in this example, by selecting this part, more detailed information (detailed numerical values, etc.) of the experimental data can be obtained instead of the analysis data. It is supposed to be displayed.

Further, when an experiment is performed on a plurality of target samples in a series of experiments using the same protocol, this may be switched and displayed for each target sample. In the example shown in FIG. 5, a tab 104 is shown in the upper right corner of the protocol chart, and by selecting a tab according to the target sample ID to be viewed, experimental data and analysis data for each target sample are displayed. It has become like. When displaying the analysis data, the analysis data of a plurality of target samples may be superimposed and displayed for comparison. Further, the display may be switched not for each target sample but for each result sample.

FIG. 6 is a flow chart showing an operation in which the experiment data recording device 1 records the experiment data. It should be noted that this flow is shown as an example, and does not necessarily require that all the operations shown here be performed.

First, in step ST1, protocol data is downloaded from the protocol server 32 or the like to the protocol data storage unit 10 and read. The protocol data includes a protocol ID and procedure data.

In the following step ST2, the protocol chart is displayed on the display unit 27 based on the read protocol data.

In step ST3, the experiment ID issuing unit 13 issues the experiment ID, and the experiment ID recording unit 12 records the experiment ID. The experiment ID is issued by, for example, the experiment ID issuing unit 13 causing the experiment ID generation device 24 to generate the experiment ID.

In step ST4, the experimental environment data recording unit 14 collects and records necessary information from various devices. The various devices here depend on the information required as the experimental environment data. For example, if it is the ID of the experimenter, it may be an ID card reader, or if it is the ID of the laboratory equipment used for the experiment, it may be. It may be the laboratory equipment itself.

In step ST5, the target sample ID recording unit 15 records the ID of the target sample used in the experiment. The target sample ID may be read by, for example, a reader 17.

In step ST6, the receiving unit 21 receives the operation record of the laboratory equipment 19 used in the experiment, and the operation recording recording unit 18 records the operation record. This record is made for each procedure while the procedures included in the protocol are performed, and the individual action records collected are recorded in association with each corresponding procedure included in the protocol.

In step ST7, the result sample ID recording unit 16 records the ID of the result sample obtained as a result of the experiment. As a result, the sample ID may also be read by, for example, the reader 17.

In step ST8, the analysis data recording unit 22 records the analysis data obtained from the analyzer 23. The analysis data is associated with the result sample ID of the result sample subjected to the analysis.

In step ST9, the experimental data thus obtained is subjected to falsification prevention processing by the falsification prevention unit 33, and in the subsequent step ST10, the experimental data storage unit 25 stores the experimental data in the experimental data storage device 26. As a result, the experimental data associated with the protocol ID and subjected to the tamper-proof processing will be automatically recorded.

FIG. 7 is a flow chart showing an operation in which the experiment data recording device 1 superimposes and displays the experiment data on the protocol chart. It should be noted that this flow is shown as an example, and does not necessarily require that all the operations shown here be performed.

First, in step ST11, the experimental data to be displayed is read from the experimental data storage device 26 and stored in the experimental data storage unit 11. This step is not necessary if the experimental data you want to display is already stored.

In the following step ST12, the protocol data having the protocol ID associated with the experimental data is downloaded from the protocol server 32 and stored in the protocol data storage unit 10. Since the protocol ID is an ID uniquely assigned to the protocol, the correct protocol used when obtaining the experimental data is downloaded based on the protocol ID. If the experimental data includes protocol data, this step is not necessary.

In step ST13, the protocol display unit 28 displays the protocol chart, and in subsequent step ST14, the operation record display unit 29 displays the operation record in association with the symbol indicating the procedure in the protocol chart, and further, in step ST15, the analysis data is displayed. The analysis data is displayed by the unit 30. The results displayed in this way are as illustrated in FIG.

In the above description, the tamper-proof unit 33 has described an example in which the experimental data storage unit 25 performs tamper-proof processing when storing the experimental data stored in the experimental data storage unit in the experimental data storage device. With respect to this example, FIG. 8 shows a functional block diagram of the experimental data recording device 1 according to a modified example in which the falsification prevention processing is further strengthened.

In the experiment data recording device 1 according to the present embodiment, the tampering prevention unit 33 is not between the experiment data storage unit 25 and the communication unit 20, but each recording unit included in the experiment data recording device 1, here, the experiment ID recording unit. 12. The experimental environment data recording unit 14, the target sample ID recording unit 15, the result sample ID recording unit 16, the operation recording recording unit 18, the analysis data recording unit 22, and the experimental data storage unit 11 are arranged so as to intervene. There is. Then, every time each recording unit records various information, falsification prevention processing is performed.

As a result, the experimental data at the stage stored in the experimental data storage unit 11 before being stored in the experimental data storage device 26 is also subjected to the tamper-proof processing, so that the experiment before the tamper-proof processing is performed. It becomes extremely difficult to tamper with the data.

The falsification prevention process by the falsification prevention unit 33 in this modified example does not necessarily have to be performed on the recording of various information by all the recording units of the experimental data recording device 1, and there are circumstances in which falsification should be prevented. It may be done only for information. For example, at least, falsification prevention processing may be performed every time the operation record recording unit 18 records the operation record.

In the experimental data recording device 1 according to the above-described embodiment, the experimental data recording device 1 also performs an operation of superimposing the experimental data on the protocol chart and displaying it. However, from the inventor's point of view, the request to view the experimental data together with the protocol is not limited to the experimenter, but may be made by a third party who wants to verify the experimental results and refer to them. It is a thing. At this time, if it can be confirmed from a third party that the experimental result to be viewed was certainly performed according to the protocol, and that the result is genuine and the objectivity and accuracy are guaranteed. It is considered that there are great merits such as saving a lot of time and labor required for verification of the result.

Therefore, the inventor has further invented an experimental data display device 2 that associates experimental data with a protocol and displays it objectively and with high reliability in combination with the experimental data recording device 1. The experimental data display device 2 according to the above will be described.

Since the physical configuration of the experimental data display device 2 is the same as that of the experimental data recording device 1, FIG. 1 will be referred to, and duplicate description thereof will be omitted. The experimental data display device 2 is similar to the experimental data recording device 1 in that it is realized by executing a program for operating the computer as the experimental data display device 2 on a general computer.

FIG. 8 is a functional block diagram of the experimental data display device 2. Since the experimental data display device 2 includes a configuration common to the experimental data recording device 1 in terms of its function, the same functional blocks as those shown in FIG. 2 for the experimental data recording device 1 are the same in the figure. References shall be made and duplicate description shall be omitted.

The experiment data reading unit 34 reads the experiment data to be displayed from the experiment data storage device 26 via the communication unit 20 and stores it in the experiment data storage unit 11. Further, the protocol data reading unit 35 reads the protocol data having the protocol ID associated with the read experimental data from the protocol server 32 and stores it in the protocol data storage unit 10.

The operations of the post-experiment protocol display unit 28, the operation record display unit 29, and the analysis data display unit 30 are the same as those of the experiment data recording device 1 described above. Further, the operation of the experimental data display device 2 is the same as that described with reference to FIG.

In this way, by identifying and reading the protocol data based on the operation data associated with the protocol ID and displaying the operation data and the analysis data by superimposing them on the protocol chart, the experimental data can be associated with the protocol and objective. Moreover, it can be displayed with high reliability.

The configurations of the embodiments described above are shown as specific examples, and the invention disclosed in the present specification is not intended to be limited to the configurations of these specific examples themselves. Those skilled in the art may make various modifications to these disclosed embodiments, and the controls shown in the disclosed flowcharts may be replaced by other controls that perform equivalent functions. It should be understood that the technical scope of the invention disclosed herein also includes modifications made in this way.

1 Experimental data recording device, 1a CPU, 1b RAM, 1c external storage device, 1d GC, 1e input device, 1f I / O, 1g data bus, 1h monitor, 2 experimental data display device, 10 protocol data storage unit, 11 experiments Data storage unit, 12 Experiment ID recording unit, 13 Experiment ID issuing unit, 14 Experimental environment data recording unit, 15 Target sample ID recording unit, 16 Result sample ID recording unit, 17 Reader, 18 Operation recording recording unit, 19 Laboratory equipment, 20 communication unit, 21 receiver, 22 analysis data recording unit, 23 analyzer, 25 experiment data storage unit, 26 experiment data storage device, 27 intra-experiment protocol display unit, 28 post-experiment protocol display unit, 30 analysis data display unit, 31 Protocol creator, 32 Protocol server, 33 Anti-tampering unit, 34 Experimental data reading unit, Protocol data reading unit, 100a, 100b, 100c symbols.

Claims (19)

Experimental data that records experimental data that is a protocol in at least one of the fields of biochemistry and biotechnology, and is a record of experiments based on a protocol in which multiple procedures and their sequence are described so that a given experiment is performed. It ’s a recording device,
A receiver that receives the operation record of the laboratory equipment,
An experiment ID recording unit that records an experiment ID, which is an experiment-specific ID, in association with a protocol-specific protocol ID.
Each received the operation record, among the plurality of steps involved in the protocol, and the operation recording the recording unit to record in association with the corresponding procedure,
An experimental protocol display unit that displays on the monitor a plurality of symbols indicating each of the plurality of procedures included in the protocol during the experiment.
An operation record display unit that displays the operation record on the monitor in association with each of the plurality of symbols.
Experimental data recording device with. The target sample ID, which is the ID of the sample that was the target of the experiment, is recorded in association with the experiment ID.
Target sample ID recording unit and
The result sample ID, which is the ID of the sample obtained as a result of the experiment, is recorded in association with the experiment ID.
Result sample ID recording unit and
The experimental data recording device according to claim 1. The experimental data recording device according to claim 1 or 2, further comprising an experimental environment data recording unit that records experimental environment data in association with the experiment ID. The experimental data recording device according to any one of claims 1 to 3, wherein the experimental instrument includes an instrument directly operated by an experimenter. The experimental data recording device according to claim 4, wherein the laboratory instrument includes an electric pipette. The experimental data recording device according to any one of claims 1 to 3, wherein the laboratory instrument includes a robot that executes an experiment based on the protocol. The experiment data recording device according to any one of claims 1 to 6, which has an experiment ID issuing unit for issuing the experiment ID for each experiment. The experiment data recording device according to claim 7, wherein the experiment ID issuing unit acquires an experiment ID generated by an external experiment ID generation device. The experimental data recording device according to any one of claims 1 to 8, which has a falsification prevention unit for applying a falsification prevention treatment to the experimental data. The experimental data recording device according to claim 9, wherein the falsification prevention unit performs a falsification prevention process at least every time the operation recording unit records an operation record. The experimental data recording device according to any one of claims 1 to 9, further comprising an experimental data storage unit for storing the obtained experimental data in an external experimental data storage device. The experiment according to any one of claims 1 to 11, which has an analysis data recording unit for recording analysis data which is data of analysis results for a sample obtained as a result of an experiment in association with a result sample ID of the sample. Data recording device. A computer program that causes a computer to function as the experimental data recording device according to any one of claims 1 to 12. The in-experimental protocol display unit includes a first symbol indicating the initial state of the laboratory equipment, a second symbol indicating the final state of the laboratory equipment, and a third symbol indicating each of the plurality of procedures. , The first symbol, the third symbol, and the second symbol are arranged in this order and displayed on the monitor during the experiment.
The experimental data recording device according to any one of claims 1 to 12. During the experiment, the in-experimental protocol display unit displays on the monitor a symbol indicating the initial state of the experimental instrument and an arrow extending from the symbol indicating the initial state along the direction in which the plurality of procedures are performed. At the same time, the symbols indicating the initial state and the arrows for different experimental instruments are displayed separated in the direction in which the arrows intersect in the extending direction.
The experimental data recording device according to any one of claims 1 to 12. Experimental data that records experimental data that is a protocol in at least one of the fields of biochemistry and biotechnology and biotechnology, and is a record of experiments based on a protocol in which multiple procedures and their sequences are described so that a given experiment is performed. It ’s a recording method,
Receive the operation record of the laboratory equipment,
The experiment ID, which is an ID unique to the experiment, is recorded in association with the protocol ID unique to the protocol.
Each of the received operation records is recorded in association with the corresponding procedure among the plurality of procedures included in the protocol.
During the experiment, a plurality of symbols indicating each of the plurality of procedures included in the protocol were displayed on the monitor.
An experimental data recording method for displaying the operation record on the monitor in association with each of the plurality of symbols. With respect to experimental data, which is a protocol in at least one of the fields of biochemistry and biotechnology and biotechnology, which is a record of experiments based on a protocol in which multiple procedures and their sequence are described so that a given experiment is performed.
During the experiment, an experimental protocol display unit that displays a plurality of symbols indicating each of the plurality of procedures included in the protocol on the monitor.
A post-experiment protocol display that displays the protocol in which the experiment was performed,
An operation record display unit that displays the operation record of the laboratory equipment used in the experiment, which is included in the experimental data corresponding to the protocol, is associated with each of the symbols indicating the plurality of procedures included in the protocol. Experimental data display device to have. The experimental data display device according to claim 17, further comprising an analysis data display unit that displays analysis data corresponding to the experiment data. With respect to experimental data, which is a protocol in at least one of the fields of biochemistry and biotechnology and biotechnology, which is a record of experiments based on a protocol in which multiple procedures and their sequence are described so that a given experiment is performed.
During the experiment, a plurality of symbols indicating each of the plurality of procedures included in the protocol were displayed on the monitor.
Display the protocol in which the experiment was performed
Experimental data display that displays the operation record of the laboratory equipment used in the experiment included in the experimental data corresponding to the protocol in association with each of the plurality of symbols indicating the plurality of procedures included in the protocol. Method.

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