JP6753142B2 - Oral composition - Google Patents

Description

The present invention relates to an oral composition containing one or more selected from potassium salts and aluminum salts.

Potassium salts such as potassium nitrate and aluminum salts such as aluminum lactate are incorporated into oral compositions as active ingredients for improving hypersensitivity. However, the oral composition containing these has a poor usability because the palatability is impaired by the metallic taste of potassium and aluminum and it also has irritation. Masking with sweeteners and flavors alone is not enough to solve this problem, and more effective technical means have been desired.

Japanese Unexamined Patent Publication No. 2013-155166

The present invention has been made in view of the above circumstances, and provides an oral composition in which the metallic taste of a potassium salt or an aluminum salt is suppressed, the taste is not sarcastic, there is no irritation, and a refreshing feeling is obtained after use. With the goal.

As a result of diligent studies to achieve the above object, the present inventor has added (B) sodium chloride and (C) allylphenoxy to an oral composition containing at least one selected from (A) potassium salt and aluminum salt. By blending one or more components selected from acetate, ambrette seed oil, methyldihydrojasmonate and geraniol, the metallic taste derived from (A) potassium salt and aluminum salt is eliminated, and there is no irritation. It has been found that the composition for oral cavity gives a refreshing feeling after use, and the present invention has been made. (B) Sodium chloride alone has a rather strong metallic taste and irritation, and (C) the above-mentioned specific fragrance component alone does not provide a refreshing feeling and irritation relief.

Therefore, the present invention provides the following oral compositions.
[1]. One or more components selected from (A) potassium salt and aluminum salt, (B) sodium chloride, and (C) allylphenoxyacetate, ambrette seed oil, methyldihydrojasmonate and geraniol. Oral composition contained.
[2]. The oral composition according to [1], wherein the compounding mass ratio represented by (A) / (B) is 0.01 to 50.
[3]. The oral composition according to [1] or [2], wherein the compounding mass ratio represented by [(A) + (B)] / (C) is 200 to 20,000.
[4]. The oral composition according to any one of [1] to [3], wherein the component (C) is at least one selected from allyl phenoxy acetate, ambrette seed oil and methyl dihydrojasmonate.
[5]. The blending amount in the oral composition is 0.1 to 15% by mass for the component (A), 0.1 to 15% by mass for the component (B), and 0.0005 to 0.1% by mass for the component (C). The oral composition according to any one of [1] to [4].

According to the present invention, it is possible to provide an oral composition in which the metallic taste of potassium salt and aluminum salt is suppressed, the taste is not unpleasant, there is no irritation, and a refreshing feeling can be obtained after use.

Hereinafter, the present invention will be described in detail.
(A) One or more selected from potassium salt and aluminum salt These components have an effect of suppressing hypersensitivity. Examples of the component (A) include potassium nitrate, potassium citrate, potassium chloride, potassium sulfate, aluminum lactate, aluminum gluconate, aluminum malonate, aluminum malate and the like, and these may be used alone or in combination of two or more. Can be used in combination. Of these, potassium nitrate and aluminum lactate are preferable. As the potassium nitrate, for example, a product manufactured by Otsuka Chemical Co., Ltd. can be used. As the aluminum lactate, for example, a product manufactured by Musashino Chemical Laboratory can be used.

The blending amount of the component (A) in the oral composition is preferably 0.1 to 15% by mass, more preferably 0.5 to 10% by mass, still more preferably 1 to 8% by mass. By setting the blending amount to 0.1% by mass or more, the hypersensitivity suppressing effect is more exerted, and on the other hand, even if the blending amount exceeds 15% by mass, the hypersensitivity suppressing effect is increased in proportion to the increase in the blending amount. It cannot be expected, it may give a metallic taste, and the usability may be inferior.

(B) Sodium chloride By blending the component (B), a refreshing feeling after use can be imparted, but when used in combination with the component (A), not only does the refreshing feeling not appear, but the irritation derived from sodium chloride is enhanced. This causes problems in usability. As the sodium chloride, a commercially available product can be used. For example, a product manufactured by Nihonkaisui Co., Ltd. can be used as a carefully selected special grade salt.

The blending amount of the component (B) in the oral composition is preferably 0.1 to 15% by mass, more preferably 0.5 to 15% by mass, still more preferably 1 to 10% by mass. When the blending amount is 0.1% by mass or more, a more sufficient refreshing feeling after use can be obtained, and when it exceeds 15% by mass, saltiness and irritation become too strong, and rather the refreshing feeling may be weakened. is there.

(C) One or more selected from allylphenoxyacetate, ambrette seed oil, methyldihydrojasmonate and geraniol (C) A specific fragrance component of the component (C) is used in combination with the component (B) to make it unpleasant (metallic taste). Can be masked and the irritation derived from salt can be suppressed. The component (C) can be used alone or in combination of two or more. Of these, allyl phenoxy acetate, amblet seed oil, and methyl dihydrojasmonate are preferable, and allyl phenoxy acetate and amblet seed oil are more preferable, and it is desirable to contain both in combination from the viewpoint of flavor. For example, a product manufactured by Taiyo Fragrance Co., Ltd. can be used for allyl phenoxyacetate, and a product manufactured by Ve Manfis Co., Ltd. can be used for ambrette seed oil. The effect of the present invention cannot be obtained with a menthol or a mint oil-containing fragrance that does not contain the component (C).

The blending amount of the component (C) in the oral composition is preferably 0.0005 to 0.1% by mass, more preferably 0.0008 to 0.02% by mass, and preferably 0.001 to 0.01% by mass. More preferred. By setting the blending amount to 0.0005% by mass, the effect of sarcasm (metal taste) masking can be further obtained, and if it exceeds 0.1% by mass, the bitterness of the component (C) itself may occur.

When the component (A) and the component (B) are used in combination, there are problems in usability such as a stronger sarcasm (metallic taste) and a stronger irritation than when the component (A) or (B) is used alone. The mass ratio of (A) / (B) is preferably 0.01 to 50, more preferably 0.5 to 10 and even more preferably 0.8 to 8. If it is less than 0.01, irritation derived from sodium chloride will be expressed, which causes a problem in usability. On the other hand, if it exceeds 50, a sufficient effect of sarcasm (metallic taste) masking may not be obtained.

The compounding mass ratio represented by [(A) + (B)] / (C) is preferably 200 to 20,000, preferably 400 to 10,000. By setting the range to such a range, the sarcasm (metallic taste) derived from the component (A) can be more masked, and the irritation derived from the component (B) can be suppressed while giving a refreshing feeling after use. , The usability can be dramatically improved.

The oral composition of the present invention includes dentifrices (dentifrices) such as dentifrices, liquid dentifrices, dentifrices, and liquid dentifrices, mouthwashes, mouthwashes, oral pasta, mouthwash tablets, chewing gum, etc. It can be in various forms and can be suitably prepared as a dentifrice.

In the oral composition of the present invention, in addition to the above-mentioned essential components, other known additives can be blended as necessary without interfering with the effects of the present invention. As the additive, for example, an abrasive, a thickener, a binder, a surfactant, a sweetener, a preservative, various active ingredients, a fragrance other than the component (C), a colorant, a pH adjuster and the like can be blended. , These components and water (remaining portion) can be mixed and produced. As the additive component, one kind alone or two or more kinds can be appropriately selected and used.

As abrasives, silicic anhydride, silica gel, aluminosilicate, zirconosilicate, calcium dibasic anhydride, calcium dibasic dihydrate dihydrate, calcium pyrophosphate, alumina, titanium dioxide, crystalline zirconium silicate, polymethylmetha Examples thereof include acrylate, insoluble calcium metaphosphate, calcium carbonate, magnesium carbonate, magnesium tertiary phosphate, zeolite, calcium tertiary phosphate, calcium tetraphosphate, calcium eighth phosphate, hydroxyapatite, fluoroapatite, and synthetic resin-based abrasives. The blending amount of these abrasives is preferably 2 to 50% by mass, particularly 10 to 40% by mass in the oral composition.

Examples of the thickener include sugar alcohols such as sorbitol and glycerin, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6000, ethylene glycol, and polyhydric alcohols such as reduced starch saccharified product. The blending amount is usually 5 to 50% by mass in the oral composition.

Binders include sodium polyacrylate, xanthan gum, sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carbopol, guagam, gelatin, abyssel, montmorillonite, kaolin, bentonite, polyvinyl alcohol, polyvinylpyrrolidone, carrageenan. And so on. The blending amount is usually 0.1 to 5% by mass in the oral composition.

As the surfactant, at least one selected from anionic surfactants, nonionic surfactants, and amphoteric ionic surfactants can be used. Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate, sodium lauroylmethyl taurine, sodium N-lauroyl sarcosinate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate and the like. Examples of the nonionic surfactant include polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, mono-lauric acid or diethanolamide, and sorbitan fatty acid esters. Examples of the amphoteric ion surfactant include N-alkyldiaminoethylglycine such as coconut oil fatty acid amide propyl betaine, N-lauryl diaminoethyl glycine, and N-myristyl diaminoethyl glycine, N-alkyl N-carboxymethyl ammonium betaine, and 2-alkyl. -1-Hydroxyethyl imidazoline betaine sodium and the like can be mentioned. The blending amount is usually 0.1 to 5% by mass in the oral composition.

As sweeteners, sodium saccharin, aspartame, stebioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyldihydrocalcone, perillartine, etc., and as preservatives, paraoxybenzoic acid esters such as methylparaben, butylparaben, ethylparaben, benzoic acid, etc. Examples thereof include benzoic acid such as sodium or a salt thereof.

As various active ingredients, fluorides such as sodium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, sodium salt of orthophosphoric acid, tranexamic acid, epsilon aminocaproic acid, dl-tocophenol acetate, etc. α-bisabolol, dihydrocholesterol, chlorohexidine salts, azulene, glycyrrhetin, glycyrrhetinic acid, glycyrrhizinic acid and its salts, chelating phosphoric acid compounds such as copper chlorophyllin sodium, chlorophyll, glycerophosphate, copper compounds such as copper gluconate, hydroxamic acid and Its derivatives, sodium tripolyphosphate, methoxyethylene, epidihydrocholesterin, benzethonium chloride, allantinchlorhydroxyaluminum, ascorbic acid, lysozyme chloride, isopropylmethylphenol, cetylpyridinium chloride, trichlorocarbanilide, zinc citrate, aubaku extract, etc. Can be mentioned. The blending amount of these active ingredients can be an effective amount within a range that does not interfere with the effects of the present invention.

Examples of fragrances other than the component (C) include peppermint oil, spearmint oil, peppermint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, and peppermint oil. Oil, cardamon oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, camo mill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil , Jasmine oil, iris concrete, absolute peppermint, orange flower and other natural fragrances, and processing of these natural fragrances (pre-reservoir cut, rear-reservoir cut, distilling, liquid extraction, essence, powder fragrance, etc.) Fragrances and menthol, carboxylic, anator, cineole, methyl salicylate, synamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, timol, linalol, linaryl acetate, limonene, menthon, mentyl acetate , N-ethyl-p-menthan-3-carboxamide, pinen, octylaldehyde, citral, pregon, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, methylanthranilate, ethylmethylphenyl Single fragrances such as glycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethylsulfide, cycloten, furfural, trimethylpyrazine, ethyllactate, methyllacate, ethylthioacetate, and strawberry flavor, Known flavoring materials used in toothpaste compositions can be used, such as blended flavors such as apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. .. It should be noted that the effect of the present invention cannot be obtained with a menthol or a mint oil-containing fragrance that does not contain the above component (C).

The blending amount of these perfume materials is not particularly limited, but when blended, it is preferable to use 0.000001 to 1% by mass in the oral product. Further, as the perfume for perfume using the above perfume material, it is preferable to use 0.1 to 2.0% by mass in the oral composition.

As the colorant, Blue No. 1, Yellow No. 4, Green No. 3, and the like can be blended in ordinary amounts.

Examples of the pH adjuster include organic acids such as citric acid, lactic acid and malic acid and salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate and sodium dihydrogen phosphate. , Ordinary amounts can be blended.

The present invention comprises an oral composition containing one or more selected from (A) potassium salt and aluminum salt, (B) sodium chloride and (C) allylphenoxyacetate, ambrette seed oil, methyldihydrojasmonate and It is possible to provide a method for suppressing an unpleasant taste (metallic taste) of the above-mentioned component (A), which comprises blending one or more kinds of components selected from geraniol. Suitable ingredients, blending amounts, etc. are the same as above.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. Unless otherwise specified in the following examples, "%" of the composition indicates mass%, the ratio indicates mass ratio, and the amount of each component in the table is the amount converted into pure content.

[Examples 1 to 22, Comparative Examples 1 to 3]
Toothpaste compositions having the compositions shown in Tables 1 to 4 were prepared by a conventional method. To prepare the toothpaste composition, potassium nitrate (manufactured by Otsuka Chemical Co., Ltd.), aluminum lactate (manufactured by Musashino Chemical Research Institute), sodium chloride (selected special grade salt, Nihonkaisui Co., Ltd.), allylphenoxyacetate (Taiyo Fragrance Co., Ltd.) ), Amblet seed oil (manufactured by Ve Manphis Fragrance Co., Ltd.), methyldihydrojasmonate (manufactured by Nippon Zeon Co., Ltd.), and geraniol (manufactured by Clare Co., Ltd.). Other ingredients include sorbit 70% aqueous solution, propylene glycol, silicic anhydride, sodium alginate, carrageenan, polyoxyethylene hydrogenated castor oil, sodium lauroylmethyltaurine, coconut oil fatty acid amide propylbetaine, titanium oxide, sodium saccharinate, monofluorophosphate. For sodium, a standard product of Sodium alginate (standard for raw materials for non-pharmaceutical products) was used, and for purified water, a standard product of Carrageenan (standard for raw materials for cosmetics) was used.

The obtained dentifrice composition (dentifrice) was evaluated as follows. Ten subjects took 1 g of the toothpaste composition on a toothpaste (Lion Corporation, Denter Systema Lion Hub Brush Regular), and after brushing for 3 minutes, there was no sarcasm (metallic taste), no irritation, and refreshing after use. A sensory test was performed on the feeling based on the following scores. The average value of 10 people was calculated, and the results are shown in Tables 1 to 4 according to the following criteria.

(I) No sarcasm (metal taste) (score)
4 points: No sarcasm (metal taste) 3 points: Almost no sarcasm (metal taste) 2 points: Feel sarcasm (metal taste) 1 point: Very sarcasm (metal taste) (evaluation criteria)
No sarcasm (metallic taste) Average score ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: 1.0 Points or more and less than 2.0 points

(Ii) No stimulation (score)
4 points: I do not feel any stimulus 3 points: I hardly feel stimulus 2 points: I feel stimulus 1 point: I feel stimulus very much (evaluation criteria)
Non-stimulation average score ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points Δ: 2.0 points or more and less than 3.0 points ×: 1.0 points or more 2. Less than 0 points

(Iii) Refreshing feeling after use (score)
4 points: Very refreshing feeling after use 3 points: Feeling refreshing feeling after use 2 points: Feeling refreshing feeling after use 1 point: Feeling refreshing feeling after use at all (evaluation criteria)
Refreshing feeling after use Average score ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: 1.0 points or more Less than 2.0 points

[Fragrance composition]
l-Menthol (manufactured by Takasago International Corporation) 20%
Peppermint oil (manufactured by Takasago International Corporation) 50%
Anethole (manufactured by Takasago International Corporation) 5%
Ethanol (manufactured by Japan Alcohol Trading) 25%
100% in total

From the results shown in Tables 1 to 4, the dentifrice composition of the present invention was good in terms of no sarcasm (metallic taste), no irritation, and a refreshing feeling after use. On the other hand, the dentifrice composition lacking any of the essential requirements of the present invention was inferior to any of the above evaluations and could not achieve the object of the present invention.

Claims (4)

(A) Potassium salt and one or more selected from aluminum salts, (B) sodium chloride, and (C) an oral composition containing allyl phenoxyacridone cetearyl over preparative. The oral composition according to claim 1, wherein the compounding mass ratio represented by (A) / (B) is 0.01 to 50. The oral composition according to claim 1 or 2, wherein the compounding mass ratio represented by [(A) + (B)] / (C) is 200 to 20,000. The blending amount in the oral composition is 0.1 to 15% by mass for the component (A), 0.1 to 15% by mass for the component (B), and 0.0005 to 0.1% by mass for the component (C). The oral composition according to any one of claims 1 to 3 .