JP6728302B2 - Composition for interdental brush - Google Patents

Description

The present invention relates to an interdental brush composition and the like.

A composition having a relatively low water content and a relatively high amount of hydrocarbon oil usually has poor stability over time, and even if emulsified with an emulsifier, the hydrocarbon oil often separates when stored for a long period of time. Is. Therefore, it has been difficult to use it for each purpose (for example, oral composition).

JP, 2014-189550, A JP, 2009-95253, A

An object of the present invention is to prepare an interdental brush composition having good stability over time even though it contains a hydrocarbon oil.

The present inventors have found that a composition containing a hydrocarbon oil, a polyhydric alcohol, and a polyglycerin fatty acid ester may have good stability over time even though the composition contains the hydrocarbon oil, and further improvements have been made. The present invention has been completed.

The present invention includes the subject matter described in the following sections, for example.
Item 1.
(A) hydrocarbon oil,
An interdental brush composition containing (B) a polyhydric alcohol and (C) a polyglycerin fatty acid ester,
(I) The HLB of the component (C) is 13 or more and 18 or less, and the content mass ratio (B/A) of the component (A) and the component (B) is 0.4 to 1.1, or (ii)(C ) Component HLB is 12 or more and less than 13, and B/A is 0.1 to 1.1.
Which is a composition for an interdental brush.
Item 2.
Item 2. The interdental brush composition according to Item 1, wherein the content of water is 5% by mass or less.
Item 3.
Item 3. The interdental brush composition according to Item 1 or 2, which is a non-aqueous composition.
Item 4.
Item 4. The composition for interdental brushes according to any one of Items 1 to 3, wherein the hydrocarbon oil is paraffin.
Item 5.
Item 5. The interdental brush composition as described in any one of Items 1 to 4, wherein the polyhydric alcohol is glycerin.

It is possible to provide a composition for an interdental brush that contains hydrocarbon oil and is excellent in stability over time.

Hereinafter, each embodiment included in the present invention will be described in more detail. The present invention preferably includes an interdental brush composition, a method for producing the composition, and the like, but is not limited thereto, and the present invention includes all disclosed in the present specification.

The composition for an interdental brush included in the present invention contains (A) a hydrocarbon oil, (B) a polyhydric alcohol, and (C) a polyglycerin fatty acid ester. Hereinafter, the composition for interdental brushes may be referred to as the “composition for interdental brushes of the present invention”. In addition, each of the components (A) to (C) may be referred to as “component (A)”, “component (B)”, “component (C)”, and the like.

Interdental brushes are known as tools for cleaning dirt between teeth or between teeth and gums. In the present invention, the interdental brush preferably includes a handle portion including a grip portion for a user to grip, a core material joined to the handle portion, and a filament bundle implanted on the core material. The brush length of the interdental brush is, for example, preferably about 8 to 14 mm, more preferably about 10 to 12 mm. The brush tip diameter of the interdental brush is preferably, for example, about 1.5 to 3.2 mm, more preferably about 2.0 to 2.5 mm. The brush rear end diameter of the interdental brush is preferably, for example, about 1.5 to 7.0 mm, more preferably about 2.0 to 4.0 mm. The minimum passage diameter of the interdental brush is preferably about 2.0 mmΦ or less, and more preferably about 1.4 mmΦ. The brush tip diameter of the interdental brush is the diameter of the brush tip portion of the interdental brush, and the brush rear end diameter of the interdental brush is the diameter of the brush end portion on the handle portion side of the interdental brush. ..

As the oral composition to be used together with the toothbrush or the interdental brush, the toothbrush is suitable for an oral composition such that the shape is retained on the brush cleaning surface because the brush is planted on one surface of the handle. On the other hand, the interdental brush has a very small area of the brush part on which the oral composition is placed, and since the short brush is attached radially around the wire, it spreads over the entire bristles and drips. Oral compositions that remain intact are suitable.

Examples of the hydrocarbon oil include paraffin, squalane, microcrystalline wax, petrolatum, ceresin, limonene, turpentine oil, and the like. Particularly, known hydrocarbon oils used for oral compositions are preferable, and squalane and paraffin are particularly preferable. Paraffin is preferred. As the squalane, both animal squalane and plant squalane can be used. For example, shark squalane and olive squalane can be preferably used. Liquid paraffin is preferable as the paraffin, and light liquid paraffin is particularly preferable. The hydrocarbon oil may be used alone or in combination of two or more.

The polyhydric alcohol is preferably exemplified by dihydric or trihydric alcohols. At least one polyhydric alcohol selected from the group consisting of dihydric alcohols and trihydric alcohols can be preferably used. The dihydric alcohol and the trihydric alcohol are not particularly limited, but preferred examples thereof include ethylene glycol, propanediol, diethylene glycol, polyethylene glycol, 1,3-butylene glycol, and glycerin. As propanediol, both propylene glycol (1,2-propanediol) and 1,3-propanediol can be preferably used. Among them, propylene glycol, 1,3-propanediol, 1,3-butylene glycol and glycerin are preferable, and glycerin is particularly preferable. The polyhydric alcohol may be used alone or in combination of two or more.

The polyglycerin fatty acid ester has, for example, 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24). The ester compound of saturated or unsaturated fatty acid of 1) and polyglycerin is preferable.

The carbon number of the fatty acid is more preferably 8 to 22, still more preferably 10 to 20, and even more preferably 10 to 18. The fatty acid may be a saturated fatty acid or an unsaturated fatty acid. In the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3 or 4, and 1 or 2 Is more preferable. The fatty acid may be a straight chain fatty acid or a branched fatty acid. As the fatty acid, for example, capric acid, lauric acid, myristic acid, stearic acid, palmitic acid, palmitoleic acid, margaric acid, oleic acid, linoleic acid, behenic acid, isocapric acid, isolauric acid, isomyristic acid, isostearic acid, isomeric acid. Palmitic acid, isopalmitoleic acid, isomalgaric acid, isooleic acid, isolinoleic acid, isobehenic acid and the like are preferably exemplified, and among them, capric acid, lauric acid, myristic acid, stearic acid, palmitic acid, oleic acid and isostearic acid are preferable. Further, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

The polyglycerin fatty acid ester is preferably a mono-, di-, tri-, tetra-, penta- or cycloester compound of the above fatty acid and polyglycerin, more preferably a mono- or diester compound.

The polyglycerol has an average 4-12 (4,5,6,7,8,9,10,11, or 12) glycerin units _{(-OCH 2 CH (OH) CH} 2 -) preferably contains, More preferably, it contains an average of 5 to 10 glycerin units.

Specific examples of preferable polyglycerin fatty acid ester include, for example, polyglyceryl-caprate-n ¹ , polyglyceryl laurate-n ¹ , polyglyceryl myristate-n ¹ , polyglyceryl stearate-n ¹ , polyglyceryl oleate-n ¹ , diester. Polyglyceryl myristate-n ¹ , polyglyceryl diisostearate-n ¹ (where n ¹ represents the number of glycerin units, and as described above, preferably 4 to 12, particularly preferably 5 or 10) and the like. To be The polyglycerin fatty acid ester may be used alone or in combination of two or more.

The HLB (Hydrophilic-Lipophilic Balance) of the component (C) used is not particularly limited as long as the effect of the present invention is not impaired. For example, about 12-18 is preferable. The upper or lower limit of the range may be, for example, 12.5, 13, 13.5, 14, 14.5, 15, 15.5, 16, 16.5, 17, or 17.5.

The content mass ratio (B/A) of the component (A) and the component (B) in the composition for an interdental brush of the present invention is (i) when the HLB of the component (C) is 13 or more and 18 or less, B/A is preferably 0.4 or more, and preferably 1.1 or less. The upper or lower limit of the range may be, for example, 0.5, 0.6, 0.7, 0.8, 0.9, or 1.0. When the HLB of the component (ii)(C) is 12 or more and less than 13, the B/A is preferably 0.1 or more, and preferably 1.1 or less. The upper or lower limit of the range may be, for example, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, or 1.0. ..

The content mass ratio (A/C) of the component (A) and the component (C) in the composition for an interdental brush of the present invention is not particularly limited as long as the effect of the present invention is not impaired. For example, it is preferably about 9 to 130, and more preferably about 12 to 125.

The content of the component (A) in the composition for an interdental brush of the present invention is not particularly limited as long as the effect of the present invention is not impaired. The component (A) is, for example, preferably 45% by mass or more and less than 90% by mass based on the total mass of the components (A), (B) and (C). The upper or lower limit of the range may be, for example, 50, 55, 60, 65, 70, 75, 80, or 85.

The content of the component (B) in the composition for an interdental brush of the present invention is not particularly limited as long as the effects of the present invention are not impaired. The component (B) is preferably, for example, 7% by mass or more, and preferably 70% by mass or less, based on the total mass of the components (A), (B), and (C). The upper or lower limit of the range may be, for example, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, or 65.

The content of the component (C) in the interdental brush composition of the present invention is not particularly limited as long as the effects of the present invention are not impaired. The component (C) is, for example, preferably 0.3 mass% or more, and more preferably 7 mass% or less, based on the total mass of the component (A), the component (B), and the component (C). .. The upper limit or the lower limit of the range is, for example, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5.5, 6, or 6.5. Good.

The composition for interdental brushes of the present invention may contain water as long as the effects of the present invention are not impaired. Specifically, for example, the content of water is preferably 5% by mass or less. Moreover, the upper limit of the content range of the water may be 4, 3, 2, 1, or 0.5 mass %. The interdental brush composition of the present invention is more preferably a composition containing no water (that is, a non-aqueous composition). However, the case where the composition contains an amount of water that is difficult to remove as an unavoidable impurity is included in the “non-aqueous composition” here.

The interdental brush composition of the present invention is preferably an emulsion composition. In addition, the composition for an interdental brush of the present invention is carbonized when it is allowed to stand at room temperature (25°C) for 1 week after preparation, more preferably at room temperature (25°C) after preparation for 1 month. It is preferable that the hydrogen oil does not separate (phase separation does not occur). The composition for the interdental brush of the present invention is not particularly limited in its form, but is preferably in the form of gel or cream, for example.

As a method for preparing the composition for an interdental brush of the present invention, for example, the component (B) and the component (C) are first stirred and mixed, and then the component (A) is gradually added to the mixture while continuing stirring. In addition, the method of mixing is mentioned. Mixing can be performed by a known stirrer (for example, a disper mixer or the like). If component (A) is added in a large amount at once, it may not be mixed uniformly, so it is preferable to add it little by little.

The composition for oral cavity of the present invention is not particularly limited, but can be formed into a usual dosage form such as a dentifrice (for example, toothpaste), a gel, an ointment preparation, a pasta preparation, etc. according to a conventional method. it can.

The interdental brush composition of the present invention may contain known components that can be contained in the oral composition, as long as the effects of the present invention are not impaired. The composition for an interdental brush of the present invention to which such components are added is prepared, for example, by a method in which, when the components (B) and (C) are first stirred and mixed, the components are added together and mixed. can do.

Examples of such known components include abrasives, wetting agents, foaming agents, fragrances, activators, sweeteners, preservatives, colorants, pH adjusters, stabilizers, corrigents, astringents, thickeners. Agents, other medicinal agents and the like. In addition, such a well-known component can be used individually by 1 type or in combination of 2 or more types.

Examples of the abrasive include dicalcium phosphate dihydrate and anhydrate, calcium phosphate, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic anhydride, silica gel, aluminum silicate, calcium silicate, Insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, polymethylmethacrylate, bentonite, zirconium silicate, hydroxyapatite, synthetic resin, bioactive glass and the like can be used.

Examples of the wetting agent include alcohol (monohydric alcohol or polyhydric alcohol), and more specifically, ethanol is used. As the polyhydric alcohol, dihydric or trihydric alcohols are preferably exemplified. The dihydric alcohol and the trihydric alcohol are not particularly limited, but preferred examples thereof include ethylene glycol, propanediol, diethylene glycol, polyethylene glycol, 1,3-butylene glycol, and glycerin. As propanediol, both propylene glycol (1,2-propanediol) and 1,3-propanediol can be preferably used. Among them, propylene glycol, 1,3-propanediol, 1,3-butylene glycol and glycerin are preferable, and propylene glycol and glycerin are particularly preferable.

Examples of the foaming agent include higher alkyl sulfate ester salts having an alkyl group with about 8 to 18 carbon atoms such as sodium lauryl sulfate and sodium myristyl sulfate; N-long chain acyl amino acid salts, α-olefin sulfonate salts, higher fatty acid sodium salts. Monoglyceride monosulfate, N-methyl-N-palmityl taurate salt, N-acyl sarcosine sodium, N-acyl glutamate, N-methyl-N-acyl taurine sodium, N-methyl-N-acyl alanine sodium, α-olefin Anionic surfactants such as sodium sulfonate may be mentioned.

Examples of the fragrance include menthol, anethole, carvone, eugenol, limonene, peppermint oil, spearmint oil, winter green, methyl salicylate, cionenel, thymol, clove oil, eucalyptus oil, rosemary oil, sage oil, lemon oil, orange oil. , Ocimene oil, citronellol, methyl eugenol and the like.

Examples of the sweetener include saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartine, thaumatin, asparatyl phenylalanyl methyl ester, α-methoxycinnamic aldehyde, xylit, sucralose, palatinose, stevia. Examples include fins.

Examples of the preservatives include parabens such as methylparaben, ethylparaben, propylparaben and butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride and the like.

Examples of the colorant include legal dyes such as Blue No. 1, Yellow No. 4, Red No. 202 and Green No. 3, mineral dyes such as ultramarine blue, reinforced ultramarine blue and dark blue, titanium oxide and the like.

Examples of the pH adjuster include citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, phytic acid, glycerophosphoric acid, acetic acid, nitric acid, or their chemically possible salts or sodium hydroxide. To be

Examples of the stabilizer include sodium edetate, sodium thiosulfate, sodium sulfite, sodium chloride, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate and the like.

Examples of the corrigent include tea extract, tea dry distillation solution, propolis extract, sodium glutamate and the like.

Examples of astringents include baking soda, aluminum lactate, zinc compounds and the like.

Examples of the thickener include hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, cellulose derivatives such as hydroxymethyl ethyl cellulose, xanthan gum, locust bin gum, carrageenan, tragacanth gum, karaya gum, gum arabic, gums such as gellan gum, and the like. Synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, thickening silica, aluminum silica gel, inorganic binders such as bee gum, sodium alginate, pectin, agar, gelatin, soybean polysaccharide, chondroitin Examples thereof include sodium sulfate and sodium hyaluronate.

Other medicinal agents include fluorine compounds such as sodium fluoride, sodium monofluorophosphate and stannous fluoride; potassium salts such as potassium nitrate and potassium chloride, strontium salts such as strontium chloride, dextranase, mutanase and amylase. , Enzymes such as protease and lytic enzyme (retechenzyme); tranexamic acid, ε-aminocaproic acid, aluminum chlorohydroxy allantoin, allantoin, dihydrocholesterol, glycyrrhizinic acid, glycyrrhetinic acid, bisabolol, isopropylmethylphenol, glycerophosphoric acid, chlorophyll, gluconic acid Copper, sodium chloride, water-soluble inorganic phosphate compound, pyrrolidonecarboxylic acid, chlorhexidine salts, triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride; acetic acid-dl-α-tocopherol acetate, pyridoxine acetate, ascorbic acid or salts thereof, etc. Vitamins; basic amino acids such as arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminopropionic acid or salts thereof; polyphenols such as flavonoids and phenolic acids; aloe, ginkgo biloba, agarix, oolong tea, Chamomile, karin, gymnema, kumasa, beetle tea, eucommia tea, dokudami, pearl barley, megusurinoki, mugwort, green tea, rooibos, lemon balm, rosemary, crabmin, lacanca, perilla, cranberry, saw millet, elder, licorice, peppermint, eucalyptus, garlic , Licorice, bodaiju, hops, cacao, mulberry leaves, thyme, eugon and other plant extracts, lactic acid bacteria, hydrogen peroxide and the like.

In addition, the blending amount of these known components can be appropriately adjusted with reference to the amounts blended in ordinary oral compositions within a range that does not impair the effects of the present invention.

In addition, in this specification, "comprising" includes "consisting essentially of" and "consisting of." is also included including "consisting essentially of" and "consisting of". Further, the invention includes all combinations of the constituent elements described in this specification.

Further, various characteristics (properties, structures, functions, etc.) described in the above-described embodiments of the present invention may be combined in any manner to specify the subject matter included in the present invention. That is, the invention includes all subject matter that is made up of any combination of the combinable properties described herein.

Hereinafter, the present invention will be described more specifically, but the present invention is not limited to the following examples. In the following, "%" means "mass %" unless otherwise specified. Further, the blending amount value of each component described in each table also indicates "mass %" unless otherwise specified. In addition, among the raw materials listed in each table, those in which the wording indicating the number of fatty acid bonds (for example, di, tri, etc.) is not described represent “mono”. (For example, polyglyceryl-10 laurate means polyglyceryl-10 monolaurate.)

Preparation of Composition for Interdental Brush According to the composition shown in Table 1 (numerical values indicate mass %), various surfactants were added in addition to glycerin and light liquid paraffin to prepare an oral composition. More specifically, the mixing was performed as follows. Glycerin and various surfactants were added to a container (beaker), and these were mixed by manual stirring using a glass rod or stirring with a disper mixer. At this time, heating was performed as necessary. While continuing stirring, light liquid paraffin was added little by little. The light liquid paraffin used is Moresco White P-70 (MORESCO). However, only Example 4 used Moresco White P-350 (MORESCO). Moresco White P-70 is a light liquid paraffin having a kinematic viscosity of 12.56 mm ² /s (40° C.) and an average molecular weight of 323, whereas Moresco White P-350 has a kinematic viscosity of 67.65 mm. ² /s (40° C.), a light liquid paraffin having an average molecular weight of 483.

Immediately after the preparation, each composition obtained was visually observed to confirm the presence or absence of phase separation. When the gel-like (emulsified state) was maintained without phase separation, it was evaluated as ◯, and when the oil phase was separated, it was evaluated as x (evaluation of preparation possibility). Further, the obtained composition was filled in a glass container, allowed to stand at room temperature (25° C.) for 1 week, and then visually observed again, and evaluated in the same manner (1 week stability evaluation). In addition, those having a one-week stability evaluation of ◯ were stable at room temperature without phase separation for about one month. The alkyl glycoside used in Table 1 is Plantacare 1200UP (manufactured by BASF), and more specifically, it is an aqueous solution of an alkyl alcohol polyglycoside having 12 to 16 carbon atoms. The water content is about 47-50%. The results are also shown in Table 1.

Evaluation of Applicability to Interdental Brushes The applicability of the compositions shown in Table 1 to interdental brushes was evaluated. A tube having a tube diameter of about 16 mm and a discharge port diameter of about 1 mm was filled with the obtained composition, and gum/interdental brush L-shaped (handle: polyethylene, bristles: nylon, wire: stainless steel, size SSS(1): Brush length 10 mm, brush tip diameter 2 mm, brush rear end diameter 2.1 mm, minimum passage diameter ~ 0.8 mmΦ) is pushed out from the tube, and a horizontal or interdental insertion part of the interdental brush is pushed out. The tip of the brush was tilted at 45° and the gum/interdental brush L-shaped was fixed. The composition on the brush was allowed to stand, and the time until the composition permeated between the filaments and drooped completely (holding time) was measured. In addition, when the gum/interdental brush L-shaped is soaked in water and the water naturally retained between filaments when the gum/interdental brush L-shaped is left, The retention time was measured when an interdental brush was used. The results are shown in Table 1.

The retention time evaluation criteria are as follows. Usually, when the composition used for filling the tube as in the present invention is placed on the interdental brush and used, the composition is delivered from the tube to the oral cavity in a relatively short time after being placed on the interdental brush. Therefore, it is suitable as a composition for an interdental brush if the interdental brush, which is more likely to drop the composition, is kept wet for 20 seconds or more. If the holding time is less than 20 seconds, the composition drips before the interdental brush is brought into the oral cavity, which makes it difficult to apply a sufficient amount of the composition to the oral cavity, which is not suitable.
◯: Holding time is 20 seconds or more.
X: Holding time is less than 20 seconds.

In addition, in the dry state and the horizontal state, none of the compositions dripped for 120 seconds or more and was retained on the interdental brush.

In addition, an SSS(1) size gum/interdental brush L-shaped with the amount of the composition about the length of the brush was inserted into a polyethylene cylinder (inner diameter φ about 1.5 mm), and the behavior of the composition By observing the above, the delivery property of the composition between the teeth was examined. The evaluation criteria for interdental delivery are as follows.
◯: The composition is delivered into a polyethylene cylinder.
Δ: The composition rides on the brush and stays at the mouth of the polyethylene cylinder. After several insertions, a portion of the composition goes into a polyethylene cylinder.
X: The composition does not enter the mouth of the polyethylene cylinder. The composition drops from the brush.

Further, the extrudability of the composition from the tube filled with the above composition was examined. The extrudability evaluation criteria are as follows.
○: Can be easily pushed out of the tube.
Δ: A little force is required for extrusion.
×: Cannot be extruded.

As a comprehensive evaluation of the applicability to interdental brushes, if the retention time, interdental delivery and extrusion properties are all evaluated as ○, ○, if there is 1 or △, △, even 1 is ×. Bad x.

The compositions shown in the examples have been found to be suitable compositions for use with interdental brushes without phase separation, maintaining a stable emulsified state even after 1 week.

Below, the prescription example of the composition for oral cavity of this invention is shown. In addition, the compounding quantity (%) of each prescription example shows mass %. A composition of glycerin:polyglyceryl laurate-10:light liquid paraffin=35:5:60 was used as a base. The following formulation was stable with no oil separation even after standing for 1 week at room temperature.

Claims (4)

(A) Light liquid paraffin ,
An interdental brush composition containing (B) a polyhydric alcohol and (C) a polyglycerin fatty acid ester,
(I) The HLB of the component (C) is 13 or more and 18 or less, and the content mass ratio (B/A) of the component (A) and the component (B) is 0.4 to 1.1, or (ii)(C ) Component HLB is 12 or more and less than 13, and B/A is 0.1 to 1.1.
Which is a composition for an interdental brush. The interdental brush composition according to claim 1, wherein the content of water is 5% by mass or less. The composition for interdental brushes according to claim 1 or 2, which is a non-aqueous composition. Polyhydric alcohol, interdental brushes composition according to any one of claims 1 to 3, which is glycerine.