JP6693504B2 - Dentifrice composition - Google Patents

Description

  TECHNICAL FIELD The present invention relates to a dentifrice composition containing a water-soluble metal salt, which has an excellent effect of suppressing bad breath, is excellent in appearance stability by preventing roughening of the preparation surface over time and liquid separation, and is suitable for preventing or suppressing bad breath.

  BACKGROUND ART Conventionally, metal salts such as copper salts and zinc salts are said to have a halitosis-preventing effect, and proposals for application to oral compositions have been made (Patent Document 1; JP-A No. 01-153622). ). However, when the above metal salt is blended in a dentifrice composition, there is a disadvantage that the effect of removing halitosis is not sufficiently exerted over time due to reaction or adsorption with an abrasive such as calcium hydrogen phosphate, calcium carbonate, etc. Patent Document 2 (Japanese Patent Laid-Open No. 02-311413) proposes a technique in which the deodorizing rate of methyl mercaptan is improved by using modified aluminum hydroxide and the effect of preventing bad breath is improved.

  On the other hand, in the field of oral care, polyethylene glycol is used as a moisturizer or a thickener. However, there are few examples in which a highly polymerized polyethylene glycol having a molecular weight of 100,000 or more is blended in a preparation, and an example of using it for improving the foaming performance of a liquid dentifrice (Patent Document 3: Japanese Patent Publication No. 2006-506359) and teeth. Example used in a dentifrice having an excellent remineralization promoting effect (Patent Document 4: JP 2013-112613 A), foaming during tooth brushing by blending a highly polymerized polyethylene glycol, an alkyl sulfate and a thickening silica. It is only to the extent that an example (Patent Document 5: International Publication No. 2010/073975) in which the property and the persistence of foam are improved is disclosed.

Japanese Patent Laid-Open No. 01-153622 JP-A-02-311413 Japanese Patent Publication No. 2006-506359 JP, 2013-112613, A International Publication No. 2010/073975

  However, it is difficult to say that the dentifrice composition containing the above metal salt is effective in preventing halitosis, and it has been desired to develop a formulation that improves the halitosis-suppressing effect and can be more effectively used for halitosis prevention.

  The present invention has been made in view of the above circumstances, and provides a dentifrice composition containing a water-soluble metal salt, which has an excellent effect of suppressing bad breath, roughens the surface of the preparation over time, and suppresses liquid separation and has excellent appearance stability. The purpose is to

  The present inventors have conducted extensive studies to achieve the above object, and as a result, (A) a water-soluble metal salt selected from a copper salt and a zinc salt is 0.01 to 1% by mass, and (B) a Brookfield type viscosity. A highly polymerized polyethylene glycol having a viscosity of 5 W / V% aqueous solution at 25 ° C. measured by a viscometer of 10 mPa · s or more and a viscosity of 2 W / V% aqueous solution measured at 25 ° C. by a viscometer of 800 mPa · s or less. When used in combination with 0.01 to 0.5% by mass, the effect of suppressing bad breath is improved, and the surface of the dentifrice preparation is roughened over time, liquid separation is suppressed, and good appearance stability can be provided. I found it. That is, according to the present invention, by properly blending the component (B) with the dentifrice composition containing the component (A), the breath odor suppressing effect is high and the appearance stability is excellent. The inventors have found that a dentifrice composition suitable for suppression can be obtained, and have completed the present invention.

That is, the bad breath suppressing effect of water-soluble metal salts such as copper salts and zinc salts is not sufficient, and the high polymerized polyethylene glycol has no bad breath suppressing effect. By using the component (B) in combination, the effect of suppressing bad breath derived from the component (A) is improved, and the appearance of the preparation is stabilized. In this case, if the component (A) and the component (B) are used in an inappropriate amount in the dentifrice composition, the surface of the preparation becomes rough over time, the texture of the dentifrice deteriorates, liquid separation occurs, and the appearance is stable. However, surprisingly, when the components (A) and (B) are properly combined, the above-mentioned problems are solved and the oral malodor suppressing effect is enhanced without deteriorating the appearance of the preparation, and it is collected from the mouth. It exerts an excellent effect of suppressing bad breath that is sufficiently suppressed and is not perceived, and the appearance of the preparation is stabilized over time, and the surface of the preparation becomes rough due to wrinkles and granular aggregates after storage for 1 month at 50 ° C. It is also possible to provide a smooth and glossy surface, to improve the texture of the dentifrice, and to suppress liquid separation.
In the present invention, the fact that the highly polymerized polyethylene glycol as the component (B) improves the bad breath suppressing effect and appearance stability of the dentifrice composition containing the component (A) means that the thickener and the moisturizing agent of the dentifrice composition are used. It cannot be predicted from the use of polyethylene glycol as a drug.

Therefore, the present invention provides the following dentifrice compositions.
[1]
(A) 0.01 to 1 mass% of one or more water-soluble metal salts selected from copper salts and zinc salts,
(B) 0.01 to 0.5 mass% of highly polymerized polyethylene glycol having a viscosity of a 5 W / V% aqueous solution of 30 to 2,000 mPa · s at 25 ° C. measured with a Brookfield viscometer , (a) component and (B) shows the percentage of the amount of component (a) / (B) is, dentifrice composition comprising 0.1 to 10 der Rukoto as a mass ratio.
[2]
The water-soluble metal salt of the component (A) is one or more selected from copper gluconate, copper citrate, copper sulfate, copper chloride, zinc gluconate, zinc sulfate and zinc citrate [1]. The dentifrice composition described.
[3]
The dentifrice composition according to [ 2 ], wherein the water-soluble metal salt of the component (A) is copper gluconate and / or zinc citrate.
[4]
(B) highly polymerized polyethylene glycol ingredients, Brook viscosity of 5W / V% aqueous solution at 25 ° C. as measured by field type viscometer is of 55 ~ 250 mPa · s [1], [2] or [3 ] The dentifrice composition of statement.
[5]
The toothpaste according to any one of [1] to [4], wherein (A) / (B), which represents the ratio of the blending amounts of the (A) component and the (B) component, is 0.5 to 2 as a mass ratio. Agent composition.
[6]
The dentifrice composition according to any one of [1] to [5], which further comprises (C) 0.01 to 3 mass% of propylene glycol alginate.
[ 7 ]
The dentifrice composition according to any one of [1] to [ 6 ], which is a toothpaste.

  According to the present invention, a dentifrice containing a water-soluble metal salt, which has an excellent halitosis-suppressing effect, and which has a rough surface of the preparation over time, has excellent appearance stability by suppressing liquid separation, and can be suitably used for preventing or suppressing halitosis. A composition can be provided.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention comprises (A) a water-soluble metal salt selected from a copper salt and a zinc salt, and (B) a 5 W / V% aqueous solution having a viscosity of 10 mPa · s at 25 ° C. measured by a Brookfield viscometer. and a highly polymerized polyethylene glycol having a viscosity of 2 W / V% aqueous solution of 800 mPa · s or less at 25 ° C. measured by the above viscometer.

  The water-soluble metal salt of component (A) is one or more selected from water-soluble copper salts and zinc salts, and examples thereof include copper gluconate, copper citrate, copper sulfate, copper chloride, zinc gluconate, Examples thereof include zinc sulfate and zinc citrate, and not only anhydrous but also hydrates containing crystal water such as copper sulfate pentahydrate can be used, but among them, copper gluconate, copper citrate, zinc citrate, etc. Especially, copper gluconate and zinc citrate are preferable.

The content of the water-soluble metal salt is 0.01 to 1% (mass%, hereinafter, the same) of the entire composition from the viewpoint of suppressing bad breath, preferably 0.01 to 0.5%, and more preferably. Is 0.05 to 0.3%. When it is blended in an amount of 0.01% or more, a sufficient bad breath suppressing effect can be obtained. The content of 1% or less is suitable for preventing deterioration of the texture of the dentifrice over time.
In addition, within the range of the above blending amount, the blending amount of the water-soluble copper salt as the component (A) is preferably 0.0014 to 0.5%, and particularly preferably 0.007 to 0.15% of copper as the whole composition. .. The amount of the water-soluble zinc salt as zinc is preferably 0.0014 to 0.5%, and more preferably 0.007 to 0.15% of the total composition.

The highly polymerized polyethylene glycol as the component (B) is a polymer compound having a structure in which ethylene glycol is polymerized, and is a 5 W / V (mass / volume (volume))% aqueous solution at 25 ° C. measured by a Brookfield viscometer. The viscosity is 10 mPa · s or more, and the viscosity of a 2 W / V% aqueous solution at 25 ° C. measured by the viscometer is 800 mPa · s or less.
When the viscosity of the 5 W / V% aqueous solution exceeds 20,000 mPa · s, the viscosity cannot be measured, so the viscosity in the 2 W / V% aqueous solution is used. That is, in the present invention, the highly polymerized polyethylene glycol has the following viscosity physical properties (1) or (2).
(1) The viscosity of a 5 W / V% aqueous solution at 25 ° C is 10 to 20,000 mPa · s.
(2) When the viscosity exceeds 20,000 mPa · s in (1), the viscosity of a 2 W / V% aqueous solution at 25 ° C. is 800 mPa · s or less. In the present invention, more preferable highly polymerized polyethylene glycol is 5 W at 25 ° C. / V% aqueous solution has a viscosity of 10 to 18,000 mPa · s, particularly 30 to 10,000 mPa · s, especially 55 to 2,000 mPa · s, and especially 55 to 250 mPa · s.
In the present invention, by using a highly polymerized polyethylene glycol having a viscosity within the above specific range as the component (B), the effect of suppressing bad breath derived from the component (A) is improved, and the roughening of the preparation surface over time is improved. , Liquid separation is suppressed, and good appearance stability is provided.
If the viscosity of the 5 W / V% aqueous solution is less than 10 mPa · s, the effect of improving the texture of the dentifrice cannot be sufficiently obtained. If the viscosity of the 2 W / V% aqueous solution exceeds 800 mPa · s, The texture deteriorates over time.

As the highly polymerized polyethylene glycol as the component (B), the following commercial products can be used.
・ POLYOX WSR N-10
(Viscosity of 5 W / V% aqueous solution, manufactured by Dow Chemical Co., Ltd .: 12 to 50 mPa · s, measuring instrument: Brookfield RVT, rotor No. 1, rotation speed 50 rpm, measuring temperature 25 ° C., measuring time 0.5 minutes)
・ POLYOX WSR N-80
(Viscosity of 5 W / V% aqueous solution: 55 to 115 mPa · s, measuring instrument: Brookfield RVT, rotor No. 1, rotation speed 50 rpm, measuring temperature 25 ° C., measuring time 0.5 minutes) (manufactured by Dow Chemical Co., Ltd.)
・ POLYOX WSR N-750
(Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 1,000 to 1,200 mPa · s, measuring instrument: Brookfield RVF, rotor No. 2, rotation speed 10 rpm, measurement temperature 25 ° C., measurement time 1 minute )
・ POLYOX WSR-205
(Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 4,500 to 8,800 mPa · s, measuring instrument: Brookfield RVF, rotor No. 2, rotation speed 2 rpm, measuring temperature 25 ° C., measuring time 5 minutes )
・ POLYOX WSR-1105
(Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 8,800 to 17,600 mPa · s, measuring instrument: Brookfield RVF, rotor No. 2, rotation speed 2 rpm, measuring temperature 25 ° C., measuring time 5 minutes )
・ POLYOX WSR N-12K
(Manufactured by Dow Chemical Co., 2W / V% aqueous solution viscosity: 400 to 800 mPa · s, measuring instrument: Brookfield RVF, rotor No. 1, rotation speed 10 rpm, measuring temperature 25 ° C., measuring time 1 minute)

  The amount of the highly polymerized polyethylene glycol as the component (B) is 0.01 to 0.5%, preferably 0.03 to 0.2%, and more preferably 0.05 to 0.1% of the total composition. %. If the blending amount is less than 0.01%, a sufficient breath odor suppressing effect and a dentifrice texture improving effect cannot be obtained. If the blending amount is too large, further improvement of the effect cannot be expected, and the appearance stability of the formulation will be deteriorated. If it exceeds 0.5%, the texture of the dentifrice cannot be maintained well and liquid separation can be suppressed. Can not.

In the present invention, when the component (A) and the component (B) are blended in an appropriate ratio, the breath odor suppressing effect is more excellent and the appearance stability is further improved. In this case, the mass ratio of (A) / (B), which represents the proportion of the components (A) and (B), is preferably 0.02 to 100, more preferably 0.1 to 10, and particularly preferably. Is 0.5 to 6, and more preferably 0.5 to 2. If the (A) / (B) ratio is too small, the effect of suppressing bad breath may not be sufficiently obtained, and if it is too large, the texture of the dentifrice may not be sufficiently improved or liquid separation may not be sufficiently suppressed. There are cases.
In addition, in the mass ratio of (A) / (B) within the above range, the ratio of the compounding amount of the water-soluble copper salt of the component (A) as copper and the compounding amount of the component (B) is shown (A-1). ) / (B) is preferably 0.003 to 50, particularly preferably 0.07 to 3 as a mass ratio. Further, (A-2) / (B) showing the ratio of the blending amount of the water-soluble zinc salt of the component (A) as zinc and the blending amount of the component (B) is 0.003 to 50 as a mass ratio, particularly 0.07-3 is preferable.

It is preferable to further add (C) propylene glycol alginate to the dentifrice composition of the present invention because the durability of the breath odor suppressing effect is improved and the metallic taste derived from the component (A) is suppressed. The propylene glycol alginate used is not particularly limited, but the viscosity of a 1% aqueous solution (20 ° C.) measured by a Brookfield viscometer is in the range of 10 to 1,300 mPa · s, particularly 10 to 200 mPa · s. preferable.
The blending amount of (C) propylene glycol alginate is preferably 0.01 to 3% of the total composition, and more preferably 0.05 to 3%. Within the above range, the effect of suppressing bad breath is particularly excellent, and the metallic taste is suppressed and the feeling of use is good.
Further, the mixing ratio of the component (A) to the propylene glycol alginate (C) is preferably 0.01 to 5 in mass ratio.

  The dentifrice composition of the present invention is preferably prepared as a toothpaste, a liquid dentifrice or the like, particularly as a toothpaste. In addition to the above-mentioned components, known components that are normally used can be blended as necessary depending on the dosage form. For example, an abrasive, a thickener, a binder, a surfactant, a sweetener, a preservative, a coloring agent, a fragrance, an active ingredient other than the above, and the like are used in a usual amount within a range that does not impair the effects of the present invention. You can

  Examples of the polishing agent include silica gel, precipitated silica, aluminosilicate, silica-based polishing agents such as zirconosilicate, calcium phosphate-based polishing agents such as dicalcium phosphate, aluminum hydroxide, alumina, calcium carbonate, and synthetic resin-based polishing agents. Be done. The content of the abrasive is usually 5 to 50%.

  Examples of the thickener include sugar alcohols such as sorbit, xylit and erythritol, and polyhydric alcohols such as glycerin and propylene glycol. The content of these thickeners is usually 5 to 50%.

  Examples of the binder include cellulosic derivatives such as sodium carboxymethyl cellulose and gums such as xanthan gum. The content of the binder is usually 0 to 5%, especially 0.1 to 5%.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate. As the nonionic surfactant, polyalcohol such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sugar alcohol fatty acid ester such as sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, etc. Examples thereof include alcohol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, and fatty acid alkanolamides.
Examples of the cationic surfactant include alkyl ammonium type and the like, and examples of the amphoteric surfactant include betaine type and imidazoline type.
The content of the surfactant is preferably 0.5 to 5% of the total composition.

  Examples of the sweetener include saccharin sodium and the like. Examples of antiseptics include paraoxybenzoic acid esters such as methylparaben, benzoic acid or salts thereof, and the like. Examples of colorants include Blue No. 1 and Yellow No. 4.

  As the fragrance, peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie. Natural fragrances such as oil, citrus oil, iris concrete, absolute peppermint, absolute rose, and orange flower, and processing of these natural fragrances (pre-cut, post-cut, fractionation, liquid-liquid extraction, essence, powder) Fragrance, etc.) and menthol, Rubon, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramenthane- 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbetyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethylmethylphenylglycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethyl Single fragrances such as o-acetate, strawberry flavors, apple flavors, banana flavors, pineapple flavors, grape flavors, mango flavors, butter flavors, milk flavors, fruit mix flavors, tropical fruit flavors, etc. Known perfume materials used in can be used in combination. The compounding amount of these fragrances is usually 0.00001 to 3%.

  As the active ingredient, known ones usually added to dentifrice compositions can be used, and for example, fluoride, bactericide, anti-inflammatory agent, enzyme, plant extract, anticalculus agent, antiplaque agent, etc. can be added. .. Specifically, sodium fluoride, fluorides such as sodium monofluorophosphate, nonionic bactericides such as isopropylmethylphenol, cationic bactericides, enzymes tranexamic acid such as dextranase, epsilon aminocaproic acid, allantoin, etc. Anti-inflammatory agents of The above-mentioned active ingredients can be added in effective amounts within a range that does not impair the effects of the present invention.

  Hereinafter, the present invention will be specifically described with reference to Examples, Comparative Examples and prescription examples, but the present invention is not limited to the following Examples. In the following examples,% means mass% unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions (toothpaste) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are also shown in Tables 1 to 3.

(1) Evaluation Method of Halitosis Suppressing Effect Five volunteers were healthy volunteers who had halitosis and did not take antibiotics within one month. Subjects were prohibited from cleaning the mouth and eating and drinking from the night before to the day of the test. In the bad breath test, the bad breath before the start of the test and after 1 hour from brushing the teeth (after the test) were collected in a tedra bag, and the breath odor intensity of 1 liter of exhaled breath collected in the tedra bag was evaluated by the three expert evaluators as follows. It was determined according to.
<Rating criteria for bad breath intensity>
0 points: No bad breath 1 point: Slight halitosis 2 points: Halitosis 3 points: Significant halitosis Further, the degree of improvement of halitosis was calculated by the following formula, and the bad breath suppression of the test composition was suppressed. The effect was evaluated according to the following criteria.
<Calculation formula of bad breath improvement>
(Improved breath odor) = (Average breath odor intensity before test)-(Average breath odor intensity after test)
In addition, the bad breath intensity average value is a value obtained by averaging the bad breath intensity of the subjects in each group.
<Evaluation criteria for bad breath control effect>
A: There is a remarkable effect. Halitosis improvement rate is 1.5 points or more. ○: Effective. The degree of improvement in bad breath is 1.0 point or more and less than 1.5 point. Δ: There is some effect. Bad breath improvement degree is 0.5 point or more and less than 1.0 point x: No effect. Halitosis improvement is less than 0.5 point

(2) Evaluation method of roughness of surface of preparation (texture of dentifrice) After storage at 50 ° C for 1 month, appearance of paste when toothpaste composition is taken out from tube to toothbrush (smoothness of surface of preparation ( Regarding the texture of the dentifrice)), three evaluators judged according to the following rating criteria.
Rating criteria 5: No wrinkles are observed, smoother and shiny 4: Wrinkles are not recognized 3: Wrinkles are slightly recognized, but there is no problem in quality 2: Wrinkles are recognized, No granular aggregates are observed 1: Wrinkles and granular aggregates are considerably observed The average score of 3 persons was obtained, and the texture of the dentifrice was evaluated according to the following criteria.
Evaluation Criteria ◎: Average score is 4.5 points or more ○: Average score is 3.0 points or more and less than 4.5 points Δ: Average score is 2.0 points or more and less than 3.0 points ×: Average score is 2.0 Less than a point

(3) Evaluation Method of No Liquid Separation After storage at 50 ° C. for one month, three evaluators evaluated the liquid separation when the dentifrice composition was taken out from the tube to the toothbrush according to the following rating criteria.
Rating criteria 5: No liquid separation is observed 4: Slight bleeding is observed in the mouth, but there is no overall problem 3: Slight bleeding is generally observed, but there is no problem in quality 2: Separation of liquid is observed throughout 1: 1: Liquid separation that is so severe as to fall from the toothbrush is observed An average point of 3 persons was obtained, and the lack of liquid separation was evaluated according to the following criteria.
Evaluation Criteria ◎: Average score is 4.5 points or more ○: Average score is 3.0 points or more and less than 4.5 points Δ: Average score is 2.0 points or more and less than 3.0 points ×: Average score is 2.0 Less than a point

The details of the raw materials used are shown below. The viscosity of the highly polymerized polyethylene glycol is the viscosity at 25 ° C. measured by a Brookfield viscometer (Brookfield RVT or RVF) as in the above. Moreover, the viscosity of polyethylene glycol # 400 measured by the same method was less than the viscosity of (B) highly polymerized polyethylene glycol.
(A) Copper gluconate; manufactured by Kanto Chemical Co., Inc., copper gluconate (A) zinc citrate; manufactured by Kanto Chemical Co., Ltd., zinc citrate (B) highly polymerized polyethylene glycol;
POLYOX WSR N-80
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Co .: 85 mPa · s (rotor No. 1, rotation speed 50 rpm, measurement time 0.5 minutes))
POLYOX WSR N-10
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Co., Ltd .: 35 mPa · s (rotor No. 1, rotation speed 50 rpm, measurement time 0.5 minutes))
POLYOX WSR N-750
(Manufactured by Dow Chemical Company, viscosity of 5 W / V% aqueous solution: 1,100 mPa · s
(Rotor No. 2, rotation speed 10 rpm, measuring time 1 minute)
POLYOX WSR N-12K
(Viscosity of 2 W / V% aqueous solution manufactured by Dow Chemical Co., Ltd .: 420 mPa · s (rotor No. 1, rotation speed 10 rpm, measurement time 1 minute))
Polyethylene glycol # 400
(Sanyo Chemical Co., Ltd., quasi-drug raw material standard 2006 average molecular weight 380
~ 420)

＊；実施例５は参考例。

*; Example 5 is a reference example.

  Next, a dentifrice composition (toothpaste) having the composition shown in Table 4 was prepared by the usual method using the same raw materials as above, and evaluated by the same method. In addition, the persistence of the bad breath suppressing effect (bad breath suppressing effect) and the metallic taste suppressing effect were evaluated by the following methods. The results are also shown in Table 4.

(4) Method for evaluating the effect of suppressing bad breath The method for evaluating the effect of suppressing bad breath is based on the method for evaluating the effect of suppressing bad breath, and after the test, the bad breath after 4 hours has been collected and the bad breath intensity is determined, and the degree of improvement of bad breath is similarly determined. Then, the effect of suppressing bad breath was evaluated.

(5) Evaluation Method of Metallic Taste Suppressing Effect Using 10 test subjects, about 1 g of the dentifrice composition was placed on a toothbrush, and when the toothpaste was brushed for 3 minutes, the metallic taste was not felt at all 4 points, which was slightly metallic. The taste was judged as 3 points, the feeling of metallic taste was 2 points, and the feeling of very metallic taste was 1 point.
The effect of suppressing the metallic taste was evaluated based on the following criteria from the average of 10 persons.
Evaluation criteria for the effect of suppressing metallic taste:
⊚: Average score of 3.5 to less than 4.0 ○: Average score of 3.0 to less than 3.5 Δ: Average score of 2.0 to less than 3.0 x: Average score 1.0 points or more and less than 2.0 points

＊１：商品名「キミロイドＢＦ」、（株）キミカ製、
１％水溶液（２０℃）の粘度：２０ｍＰａ・ｓ（ＢＬ型粘度計、ロー
ターＮｏ．１、回転数６０ｒｐｍ）

* 1: Product name "Kimiloid BF", manufactured by Kimika Co., Ltd.
Viscosity of 1% aqueous solution (20 ° C): 20 mPa · s (BL type viscometer, rotor No. 1, rotation speed 60 rpm)

[Prescription example]
Hereinafter, a prescription example is shown in Table 5. When the dentifrice composition of the formulation example was prepared in the same manner as above and evaluated in the same manner, the bad breath suppressing effect, the texture of the dentifrice, and the lack of liquid separation were all ⊚.

Claims (7)

(A) 0.01 to 1 mass% of one or more water-soluble metal salts selected from copper salts and zinc salts,
(B) 0.01 to 0.5 mass% of highly polymerized polyethylene glycol having a viscosity of a 5 W / V% aqueous solution of 30 to 2,000 mPa · s at 25 ° C. measured with a Brookfield viscometer , (a) component and (B) shows the percentage of the amount of component (a) / (B) is, dentifrice composition comprising 0.1 to 10 der Rukoto as a mass ratio.   The water-soluble metal salt of component (A) is one or more selected from copper gluconate, copper citrate, copper sulfate, copper chloride, zinc gluconate, zinc sulfate and zinc citrate. Dentifrice composition. The dentifrice composition according to claim 2 , wherein the water-soluble metal salt of the component (A) is copper gluconate and / or zinc citrate. (B) highly polymerized polyethylene glycol ingredients, toothpaste according to claim 1, wherein the viscosity of 5W / V% aqueous solution at 25 ° C. as measured by Brookfield viscometer is of 55 ~ 250 mPa · s Agent composition. (A) component and (B) shows the percentage of the amount of component (A) / (B) is, dentifrice according to any one of claims 1 to 4 is 0.5 to 2 as a mass ratio Composition. Further, the dentifrice composition according to any one of claims 1 to 5, further comprising 0.01 to 3% by mass of (C) propylene glycol alginate. Dentifrice composition according to any one of claims 1 to 6 is a toothpaste.