JP6578778B2 - Solid composition - Google Patents
Solid composition Download PDFInfo
- Publication number
- JP6578778B2 JP6578778B2 JP2015142887A JP2015142887A JP6578778B2 JP 6578778 B2 JP6578778 B2 JP 6578778B2 JP 2015142887 A JP2015142887 A JP 2015142887A JP 2015142887 A JP2015142887 A JP 2015142887A JP 6578778 B2 JP6578778 B2 JP 6578778B2
- Authority
- JP
- Japan
- Prior art keywords
- solid composition
- corn starch
- high amylose
- amylose corn
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Grain Derivatives (AREA)
- General Preparation And Processing Of Foods (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
本発明は、ハイアミロースコーンスターチを含有する固形組成物に関し、経口の医薬品又は医薬部外品、又は体内に補助的に供給するためのサプリメント等として用いられる食品分野に関するものである。 The present invention relates to a solid composition containing high amylose corn starch, and relates to the field of food used as an oral medicine or quasi-drug, or a supplement for supplementary supply into the body.
ハイアミロースコーンスターチは、消化されにくいアミロースを豊富に含むハイアミロースコーンという品種のトウモロコシから作られたコーンスターチである。ハイアミロースコーンスターチは、オーストラリアにおいて、古典的育種法によって品種改良された
non―GMOの品種である。ハイアミロースコーンスターチは、古くからフライ食品やクッキー、パンなどの食感改良剤や成形剤として用いられており、食品中に少量の配合でその目的が達成されている。
High amylose corn starch is corn starch made from a variety of corn called high amylose corn, which is rich in amylose that is difficult to digest. High amylose corn starch was bred in Australia by classical breeding methods
Non-GMO variety. High amylose corn starch has long been used as a texture improver and molding agent for fried foods, cookies, breads, and the like, and its purpose has been achieved with a small amount of food.
近年、ハイアミロースコーンスターチについて空腹時血糖値維持、食後血糖値上昇抑制、腸健康の維持等の有効性が報告されており、ハイアミロースコーンスターチを効率よく摂取できるよう高濃度で配合した食品、特にサプリメントでの開発が急務である。しかし、ハイアミロースコーンスターチは、口中に含んだ際、唾液を吸うことで口中に貼り付きが生じ、また、口溶けの悪さや特有の粉っぽさを有し、さらには、独特の不快味を呈するため、非常に摂取しづらいものである。よって、ハイアミロースコーンスターチを製品中に高濃度配合しようとする場合は、服用性コンプライアンスの面で改善が必要である。 In recent years, high amylose corn starch has been reported to be effective in maintaining fasting blood glucose level, suppressing postprandial blood glucose level elevation, maintaining intestinal health, etc., and high amylose corn starch is a high-concentration food, especially supplements. There is an urgent need for development. However, high amylose corn starch, when contained in the mouth, sticks in the mouth by sucking saliva, has a poor mouth melting and a peculiar powdery taste, and also exhibits a unique unpleasant taste Therefore, it is very difficult to ingest. Therefore, when high amylose corn starch is to be blended in the product at a high concentration, it is necessary to improve in terms of compliance.
今まで、ハイアミロースコーンスターチを高濃度含む組成物として、特許文献１の健康補助剤が報告されている。しかしながら、ハイアミロースコーンスターチ特有の口溶けの悪さや不快味を解決するものではない。 Until now, the health supplement of patent document 1 has been reported as a composition containing high concentration of high amylose corn starch. However, it does not solve the poor melting and unpleasant taste peculiar to high amylose corn starch.
また、ハイアミロースコーンスターチは流動性が悪いため、ハイアミロースコーンスターチを造粒、打錠又は包材へ充填する場合には、工夫が求められる。 Moreover, since high amylose corn starch has poor fluidity, a device is required for filling high amylose corn starch into granules, tablets, or packaging materials.
上記の問題に鑑み、本発明の目的は、ハイアミロースコーンスターチの服用性を改善した固形組成物を提供することである。あるいは、ハイアミロースコーンスターチを含む組成物の製造する際の作業性を向上することを目的とする。 In view of the above problems, an object of the present invention is to provide a solid composition having improved intake of high amylose corn starch. Or it aims at improving the workability | operativity at the time of manufacturing the composition containing a high amylose corn starch.
本発明者らは上記目的を達成するために鋭意検討した結果、糖アルコール類を配合すると、ハイアミロースコーンスターチの服用性が改善でき、また製造作業性も向上できることを見出し、本発明を完成した。
すなわち、本発明は、
（１）（ａ）ハイアミロースコーンスターチ、及び（ｂ） 糖アルコール類を含有することを特徴とする固形組成物。
（２）（ｂ）糖アルコール類が、還元パラチノース、還元麦芽糖水飴、エリスリトール、キシリトール、リビトール、アラビトール、ガラクチトール、ソルビトール、イジトール、マンニトール、マルチトール、ラクチトール、マルトトリイトール、イソマルトトリイトール、マルトテトライトール及びイソマルトテトラトールからなる群から選ばれる少なくとも１種である、（１）に記載の固形組成物、
（３）食品、経口医薬品又は経口医薬部外品である、（１）又は２に記載の固形組成物、
（４）剤型が、錠剤、チュアブル、丸剤、粉末剤、顆粒剤またはカプセル剤である、（１）〜（３）いずれかに記載の固形組成物、
（５）ハイアミロースコーンスターチの含有量が、固形組成物全体対し３０質量％以上である（１）に記載の固形組成物、
である。
As a result of intensive studies to achieve the above object, the present inventors have found that when sugar alcohols are added, the ingestibility of high amylose corn starch can be improved and the production workability can be improved, and the present invention has been completed.
That is, the present invention
(1) A solid composition comprising (a) high amylose corn starch, and (b) sugar alcohols.
(2) (b) The sugar alcohol is reduced palatinose, reduced maltose starch syrup, erythritol, xylitol, ribitol, arabitol, galactitol, sorbitol, iditol, mannitol, maltitol, lactitol, maltotriitol, isomaltoliitol, malto The solid composition according to (1), which is at least one selected from the group consisting of tetitol and isomalttetratol.
(3) The solid composition according to (1) or 2, which is a food, an oral drug, or an oral quasi drug,
(4) The solid composition according to any one of (1) to (3), wherein the dosage form is a tablet, chewable, pill, powder, granule or capsule.
(5) The solid composition according to (1), wherein the content of high amylose corn starch is 30% by mass or more based on the entire solid composition,
It is.
本発明により、服用し易いハイアミロースコーンスターチ含有固形組成物を提供することが可能となった。本発明に係る組成物は、ハイアミロースコーンスターチが高濃度含まれていても、容易に服用可能となった。また、本発明により、ハイアミロースコーンスターチを含有する固形組成物を製造する際の作業効率が向上した。 According to the present invention, it is possible to provide a high amylose corn starch-containing solid composition that is easy to take. The composition according to the present invention can be easily taken even when high concentration of high amylose corn starch is contained. Moreover, the working efficiency at the time of manufacturing the solid composition containing a high amylose corn starch by this invention improved.
本発明で用いるハイアミロースコーンスターチは、RDS(Rapid Degestible Starch、急速に消化されるでん粉)と、SDS(Slow Degestible Starch、ゆっくりと消化されるでん紛)と、RS(Resistant Starch、難性消化性でん紛)を含むものである。本発明のハイアミロースコーンスターチの含有量は、本発明の固形組成物中、３０〜９０質量％が好ましい。より好ましくは３０〜７０質量％である。 High amylose corn starch used in the present invention is RDS (Rapid Degestible Starch, rapidly digested starch), SDS (Slow Degestible Starch, slowly digested starch) and RS (Resistant Starch, difficult digestion) (Including powdered powder). As for content of the high amylose corn starch of this invention, 30-90 mass% is preferable in the solid composition of this invention. More preferably, it is 30-70 mass%.
本発明で用いられる（ｂ）成分の糖アルコール類としては、例えば、還元パラチノース還元麦芽糖水飴、エリスリトール、キシリトール、リビトール、アラビトール、ガラクチトール、ソルビトール、イジトール、マンニトール、マルチトール、ラクチトール、マルトトリイトール、イソマルトトリイトール、マルトテトライトール、イソマルトテトラトールが挙げられる。本発明の（ｂ）成分の糖アルコール類の含有量は、本発明の固形組成物中、５〜９０質量％が好ましい。 Examples of the sugar alcohols of component (b) used in the present invention include reduced palatinose-reduced maltose starch syrup, erythritol, xylitol, ribitol, arabitol, galactitol, sorbitol, iditol, mannitol, maltitol, lactitol, maltotriitol, Examples thereof include isomaltolitol, maltotetriitol, and isomalttetratol. As for content of the sugar alcohol of (b) component of this invention, 5-90 mass% is preferable in the solid composition of this invention.
本発明の固形組成物は、食品（特定保健用食品、特別用途食品、機能性食品、健康補助食品（サプリメントを含む）、経口医薬品又は経口医薬部外品など幅広く利用することができる。好ましい剤型としては、錠剤、チュアブル、丸剤、粉末剤、顆粒剤またはカプセル剤などが挙げられる。 The solid composition of the present invention can be widely used for foods (specific health foods, special-purpose foods, functional foods, health supplements (including supplements), oral medicines or oral quasi-drugs. Examples of the mold include tablets, chewables, pills, powders, granules or capsules.
本発明の固形組成物には、本発明の効果を損なわない範囲で、ビタミン類、アミノ酸類、タウリン、グルコサミン、カフェイン、カルシウム類、生薬等の成分を配合することができる。また、必要に応じて上記成分の他に安定化剤、界面活性剤、甘味剤、香料、コーティング剤、糖衣剤、発泡剤、崩壊剤、結合剤、着色剤、流動化剤、滑沢剤等を配合してもよい。 In the solid composition of the present invention, ingredients such as vitamins, amino acids, taurine, glucosamine, caffeine, calciums, herbal medicines and the like can be blended as long as the effects of the present invention are not impaired. In addition to the above components, stabilizers, surfactants, sweeteners, fragrances, coating agents, sugar-coating agents, foaming agents, disintegrating agents, binders, coloring agents, fluidizing agents, lubricants, etc., as necessary May be blended.
本発明の固形組成物の製造方法は、常法により製造することができ、特に限定されるものではない。例えば、本発明の（ａ）成分と（ｂ）成分と、必要に応じて他の成分や公知の添加剤を混合すれば粉末剤が得られる。また、この粉末剤に造粒操作を行えば造粒物（顆粒剤）が得られる。また、前記粉末剤あるいは造粒物に適宜滑沢剤等を加えて打錠すれば、錠剤、チュアブルが得られる。また、前記粉末剤を適当な方法で球状に成形すれば丸剤が得られる。本発明で得られる造粒物(顆粒剤)は流動性が良いので、特に造粒工程含む製法で本発明の固形組成物を製造する場合は、製造効率が一層高まる。
以下に、実施例を示し、本発明を詳細に説明するが、本発明は、下記の例に限定されるものではない。なお、実施例及び比較例の処方において、数値は全て質量部である。
The manufacturing method of the solid composition of this invention can be manufactured by a conventional method, and is not specifically limited. For example, a powder agent can be obtained by mixing the component (a) and the component (b) of the present invention with other components and known additives as required. Moreover, if this granule is granulated, a granulated product (granule) can be obtained. In addition, tablets and chewables can be obtained by appropriately adding a lubricant or the like to the powder or granulated product and tableting. A pill can be obtained by forming the powder into a spherical shape by an appropriate method. Since the granulated product (granule) obtained by the present invention has good fluidity, the production efficiency is further enhanced particularly when the solid composition of the present invention is produced by a production method including a granulation step.
Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to the following examples. In addition, in the prescription of an Example and a comparative example, all numerical values are a mass part.
実施例１〜８、比較例１〜２
下記表１の組み合わせを、水を使用し乳鉢にて造粒し、乾燥後に篩に通し、各組成物を得た。各組成物について、表２の評価基準に従い官能評価し、味、口溶け、粉っぽさを評価した(４名による判定)。評価点が２．５以上で改善効果があると判定した。さらに、分包材等への充填を考慮し、表３の評価基準に従い目視にて、流動性を評価した(４名による判定)。
Examples 1-8, Comparative Examples 1-2
The combinations shown in Table 1 below were granulated in a mortar using water, passed through a sieve after drying, and each composition was obtained. About each composition, sensory evaluation was performed according to the evaluation criteria of Table 2, and taste, mouth melt, and powderiness were evaluated (judgment by four persons). It was determined that the evaluation score was 2.5 or more and there was an improvement effect. Further, the fluidity was evaluated visually according to the evaluation criteria shown in Table 3 in consideration of filling into the packaging material and the like (judgment by four persons).
比較例２のハイアミロースコーンスターチを含む固形組成物は、味、口溶け、粉っぽさのすべての評価結果がとても悪く、流動性も悪かった。比較例１の結果から、糖である乳糖を配合しても、改善効果が低かった。 The solid composition containing the high amylose corn starch of Comparative Example 2 had very bad evaluation results for taste, meltability in the mouth, and powderiness, and poor fluidity. From the results of Comparative Example 1, even when lactose, which is a sugar, was blended, the improvement effect was low.
一方、実施例１〜８の固形組成物は、味、口溶け、粉っぽさが改善され、さらに流動性も良好であった。 On the other hand, the solid compositions of Examples 1 to 8 were improved in taste, melting in the mouth and powder, and also had good fluidity.
本発明により、服用性を改善したハイアミロースコーンスターチ含有固形組成物を得ることが可能となった。よって、ハイアミロースコーンスターチを高濃度含む食品（特にサプリメント）、医薬品又は医薬部外品の分野に有益である。 According to the present invention, it is possible to obtain a high amylose corn starch-containing solid composition having improved dosing properties. Therefore, it is useful in the field of foods (particularly supplements), pharmaceuticals or quasi drugs containing high concentrations of high amylose corn starch.
Claims (4)
請求項１に記載の固形組成物。 The solid composition according to claim 1, wherein the content of high amylose corn starch is 30% by mass or more based on the entire solid composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015142887A JP6578778B2 (en) | 2014-08-19 | 2015-07-17 | Solid composition |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014166674 | 2014-08-19 | ||
| JP2014166674 | 2014-08-19 | ||
| JP2015142887A JP6578778B2 (en) | 2014-08-19 | 2015-07-17 | Solid composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016044175A JP2016044175A (en) | 2016-04-04 |
| JP6578778B2 true JP6578778B2 (en) | 2019-09-25 |
Family
ID=55635055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015142887A Active JP6578778B2 (en) | 2014-08-19 | 2015-07-17 | Solid composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6578778B2 (en) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5270039A (en) * | 1975-12-08 | 1977-06-10 | Sumitomo Bakelite Co | Edible packed body |
| JPS5822080B2 (en) * | 1979-06-13 | 1983-05-06 | 住友ベークライト株式会社 | Manufacturing method of film/sheet cleaning agent |
| MY115050A (en) * | 1995-10-16 | 2003-03-31 | Mead Johnson Nutrition Co | Diabetic nutritional product having controlled absorption of carbohydrate |
| FI20011017L (en) * | 2001-05-15 | 2002-11-16 | Licentia Oy | Method for preparing an aqueous starch coating dispersion and aqueous starch coating dispersion prepared by this method |
| JP4590034B2 (en) * | 2002-01-31 | 2010-12-01 | 三菱商事フードテック株式会社 | Hard sugar coating preparation, sugar coating liquid and manufacturing method of hard sugar coating preparation |
| US8318230B2 (en) * | 2005-05-02 | 2012-11-27 | Henkel Ag & Co. Kgaa | Use of debranched starch in extrusion-spheronization pharmaceutical pellets |
| JP4859115B2 (en) * | 2006-06-07 | 2012-01-25 | 松谷化学工業株式会社 | Edible film for oral hygiene |
| JP5637624B2 (en) * | 2009-02-12 | 2014-12-10 | 富士化学工業株式会社 | Disintegrating particle composition and fast disintegrating compression molding using the same |
-
2015
- 2015-07-17 JP JP2015142887A patent/JP6578778B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016044175A (en) | 2016-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7229641B2 (en) | Rapid-melt compositions methods of making same and methods of using same | |
| WO2011008760A1 (en) | Rapid melt compositions and methods of making same | |
| JP6133445B2 (en) | Oral rapidly disintegrating composition for solid preparation | |
| JP6662312B2 (en) | Solid composition | |
| JP5054940B2 (en) | Tablet composition | |
| JPWO2005004923A1 (en) | Tablet and production method thereof | |
| JP6578778B2 (en) | Solid composition | |
| CN106822097B (en) | Orlistat-containing pharmaceutical composition for losing weight | |
| JP2013043854A (en) | Preparation containing crude drug | |
| JP6262490B2 (en) | Intraoral rapidly disintegrating tablet composition | |
| TWI690333B (en) | Manufacturing method of easy-to-take solid preparation (with nuclear ingot) and easy-to-take solid preparation | |
| JP6578779B2 (en) | Solid composition | |
| TW201636008A (en) | Very rapidly disintegrating tablet, and method for producing same | |
| JP2022120168A (en) | Solid preparation | |
| JP6341196B2 (en) | Solid preparation | |
| CN105555316B (en) | Disintegrating granule composition produced by two-stage wet granulation process and intraorally disintegrating tablet containing the same | |
| JP2008208043A (en) | Solid preparations containing carnitines | |
| JPWO2017142001A1 (en) | Granules for intraoral rapidly disintegrating tablets | |
| JP6565334B2 (en) | Solid preparation | |
| JP2016041662A (en) | Fast disintegrating tablets | |
| JP6438547B2 (en) | Intraoral rapidly disintegrating tablet composition | |
| JP6411924B2 (en) | Milk oligosaccharide tablets | |
| CA3042699A1 (en) | Compositions and methods for treating depression | |
| JP6660694B2 (en) | Silymarin-containing tablets | |
| JP4630614B2 (en) | Fast disintegrating solid preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180703 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190528 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190709 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190730 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190812 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6578778 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R157 | Certificate of patent or utility model (correction) |
Free format text: JAPANESE INTERMEDIATE CODE: R157 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |