JP6498446B2 - Transparent cosmetics - Google Patents
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- JP6498446B2 JP6498446B2 JP2015003954A JP2015003954A JP6498446B2 JP 6498446 B2 JP6498446 B2 JP 6498446B2 JP 2015003954 A JP2015003954 A JP 2015003954A JP 2015003954 A JP2015003954 A JP 2015003954A JP 6498446 B2 JP6498446 B2 JP 6498446B2
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- 239000002537 cosmetic Substances 0.000 title claims description 31
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 38
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 35
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 34
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims description 31
- 229940035936 ubiquinone Drugs 0.000 claims description 31
- -1 fatty acid ester Chemical class 0.000 claims description 25
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 10
- 229930195729 fatty acid Natural products 0.000 claims description 10
- 239000000194 fatty acid Substances 0.000 claims description 10
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 9
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 7
- JUIUXBHZFNHITF-IEOSBIPESA-N [(2r)-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] dihydrogen phosphate Chemical compound OP(=O)(O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C JUIUXBHZFNHITF-IEOSBIPESA-N 0.000 claims description 6
- 238000011156 evaluation Methods 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 239000002244 precipitate Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000004094 surface-active agent Substances 0.000 description 8
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 7
- 150000003611 tocopherol derivatives Chemical class 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000011734 sodium Substances 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 2
- 101150035093 AMPD gene Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 238000001139 pH measurement Methods 0.000 description 2
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- 239000008213 purified water Substances 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 229960004747 ubidecarenone Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 229940005561 1,4-benzoquinone Drugs 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical group CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 108010045569 atelocollagen Proteins 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- ZLSFWAPBBIIMKI-KVINTPOGSA-M dipotassium;(2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-2,4a,6a,6b,9,9,12a-heptamethyl-10-oxido-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound [K+].[K+].C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C([O-])=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H]([O-])C1(C)C ZLSFWAPBBIIMKI-KVINTPOGSA-M 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003669 ubiquinones Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
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- 230000037303 wrinkles Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、ユビキノンを含有した透明化粧料に関するものである。より詳細には、結晶性が高く、水難溶性のユビキノンを含有し、アルカリ条件下においてもユビキノンが沈殿、析出又は浮上しない等、経時安定性に優れ、さらには、きしみ感がなく、みずみずしい使用感を有する透明化粧料に関するものである。 The present invention relates to a transparent cosmetic containing ubiquinone. More specifically, it contains ubiquinone with high crystallinity and poorly water solubility, and is excellent in stability over time, such as ubiquinone does not precipitate, precipitate or float even under alkaline conditions.Furthermore, there is no squeaky feeling and a fresh feeling of use. It is related with the transparent cosmetics which have.
ユビキノンは、別名コエンザイムＱ１０、ユビデカレノン、補酵素Ｑ１０等ともいわれる生理活性成分であり、その作用は、細胞内のミトコンドリアにおけるエネルギー供給や呼吸の維持回復、細胞膜の損傷・異常の抑制等が知られている。 Ubiquinone is a physiologically active ingredient also known as coenzyme Q 10 , ubidecalenone, coenzyme Q 10, etc., and its actions are known to provide energy supply in the mitochondria in the cell, maintenance and recovery of respiration, suppression of cell membrane damage and abnormalities, etc. It has been.
またユビキノンは、上記作用の他に、紫外線で生じた肌荒れ、しわ、しみ等を目立たなくする効果や、加齢に伴う皮膚の乾燥に対しても改善効果をもたらすとされ、医薬品、医薬部外品、化粧品等に用いられてきた成分である（特許文献１）。 In addition to the above-mentioned actions, ubiquinone is said to have an effect of making skin roughening, wrinkles, and spots caused by ultraviolet rays inconspicuous, and an improvement effect on the drying of skin with aging. It is a component that has been used in cosmetics, cosmetics, etc.
しかしながら、ユビキノンは、水難溶性、高結晶性であるため、油性成分が少量もしくは含有されないような水系組成物では、容易に析出し、外観を透明に保つことが困難であるという問題があった（特許文献２）。 However, since ubiquinone is sparingly soluble in water and highly crystalline, an aqueous composition containing a small amount or no oil component has a problem that it easily precipitates and it is difficult to keep its appearance transparent ( Patent Document 2).
このような問題を解決するために従来より様々な検討がなされているが、例えば、ユビキノン、アルキルグルコース誘導体及びＨＬＢが１１以上の可溶化剤を組み合わせる技術（特許文献２）、ユビキノン、ＩＯＢ値が０．１〜０．４の油剤、ポリオキシエチレン硬化ヒマシ油及び／又はイソステアリン酸ポリオキシエチレン硬化ヒマシ油及び低級アルコールを組み合わせる技術（特許文献３）、ユビキノン及びポリオキシエチレン（３０〜４０）硬化ヒマシ油を組み合わせる技術（特許文献４）が開示されている。 In order to solve such problems, various studies have been made conventionally. For example, a technique that combines ubiquinone, an alkylglucose derivative and a solubilizer having an HLB of 11 or more (Patent Document 2), ubiquinone, and IOB value are 0.1-0.4 oil agent, polyoxyethylene hydrogenated castor oil and / or technology combining polyoxyethylene hydrogenated castor oil and lower alcohols (Patent Document 3), ubiquinone and polyoxyethylene (30-40) cured A technique for combining castor oil (Patent Document 4) is disclosed.
しかしながら、これらの技術は、酸性・中性条件下では効果があるものの、アルカリ条件下においてその効果は十分ではなかった。ユビキノンはアルカリ条件下において特に不安定であるため、アルカリ条件下であってもユビキノンを安定に含有できる技術が求められていた。 However, although these techniques are effective under acidic and neutral conditions, the effects are not sufficient under alkaline conditions. Since ubiquinone is particularly unstable under alkaline conditions, there has been a demand for a technique that can stably contain ubiquinone even under alkaline conditions.
本発明は、結晶性が高く、水への溶解性が悪いユビキノンを含有し、アルカリ条件下であっても、長期間ユビキノンが沈殿、析出又は浮上しない等、経時安定性に優れ、さらにはきしみ感がなく、みずみずしい使用感を有する透明化粧料を提供することを目的としている。 The present invention contains ubiquinone having high crystallinity and poor solubility in water, and is excellent in stability over time, such as that ubiquinone does not precipitate, precipitate or float for a long time even under alkaline conditions. An object of the present invention is to provide a transparent cosmetic having no feeling and a fresh feeling of use.
本発明者らは、上記課題を解決するため鋭意研究を重ねた結果、成分（Ａ）ユビキノン、成分（Ｂ）トコフェロール誘導体及び成分（Ｃ）ポリオキシエチレンソルビタン脂肪酸エステルを組み合わせることで上記課題を解決し得ることを見出し、本発明を完成させるに至った。 As a result of intensive studies to solve the above problems, the present inventors have solved the above problems by combining component (A) ubiquinone, component (B) tocopherol derivative and component (C) polyoxyethylene sorbitan fatty acid ester. As a result, the present invention has been completed.
本発明によれば、成分（Ａ）ユビキノン、成分（Ｂ）トコフェロール誘導体及び成分（Ｃ）ポリオキシエチレンソルビタン脂肪酸エステルを組み合わせることにより、アルカリ条件下であっても、ユビキノンの析出がなく経時安定性に優れ、さらには使用感にも優れた透明化粧料を提供することを可能とした。そのため、本発明は、これまでユビキノンを安定に含有させることが困難であったアルカリ条件下であってもユビキノンの含有が可能となるため、処方設計の幅を広げることができる。 According to the present invention, by combining the component (A) ubiquinone, the component (B) tocopherol derivative and the component (C) polyoxyethylene sorbitan fatty acid ester, there is no precipitation of ubiquinone even under alkaline conditions, and stability over time. It was possible to provide transparent cosmetics that were excellent in use and also excellent in the feeling of use. For this reason, the present invention enables the inclusion of ubiquinone even under alkaline conditions where it has been difficult to stably contain ubiquinone so far, so that the range of formulation design can be expanded.
本発明に用いられるユビキノンは、別名コエンザイムＱ１０、ユビデカレノン、補酵素Ｑ１０等と呼ばれているものであり、２，３‐ジメトキシ‐５‐メチル‐６‐ポリプレニル‐１，４‐ベンゾキノンの側鎖のイソプレン単位が１０のユビキノン類である。このようなユビキノンは、化学合成や発酵等により製造されるが、本発明に用いるユビキノンは、製造方法には限定されず、何れのものも使用することができる。 The ubiquinone used in the present invention is also called coenzyme Q 10 , ubidecalenone, coenzyme Q 10 or the like, and is located on the side of 2,3-dimethoxy-5-methyl-6-polyprenyl-1,4-benzoquinone. These are ubiquinones having 10 isoprene units in the chain. Such ubiquinone is produced by chemical synthesis, fermentation, or the like, but the ubiquinone used in the present invention is not limited to the production method, and any one can be used.
本発明に用いられるユビキノンの含有量は、特に限定されないが、０．００１〜０．３質量％が好ましく、０．０１〜０．１質量％がより好ましい。０．００１質量％よりも少ない場合には、求める効果が得られない場合があり、０．３質量％よりも多い場合には、経時的に透明性が失われる場合がある。 Although content of ubiquinone used for this invention is not specifically limited, 0.001-0.3 mass% is preferable and 0.01-0.1 mass% is more preferable. When the amount is less than 0.001% by mass, the desired effect may not be obtained. When the amount is more than 0.3% by mass, the transparency may be lost over time.
本発明に用いられるユビキノンの市販品としては、例えば、「コエンザイムＱ１０」（第一ファインケミカル株式会社製）、「ユビデカレノン「カネカ」」（株式会社カネカ製）等が挙げられる。 Examples of commercial products of ubiquinone used in the present invention include “Coenzyme Q10” (manufactured by Daiichi Fine Chemical Co., Ltd.), “Ubidecarenone“ Kaneka ”” (manufactured by Kaneka Corporation), and the like.
本発明で用いられるトコフェロール誘導体は、特に限定されないが、トコフェリルリン酸塩が好ましく、中でもトコフェリルリン酸ナトリウムがより好ましい。その含有量は、０．０５〜５質量％が好ましく、０．１〜２質量％がより好ましい。この範囲で用いれば、きしみ感がなく、みずみずしい良好な使用感を有すると同時に、外観の透明性及び経時安定性を効率よく高める効果が期待できる。 The tocopherol derivative used in the present invention is not particularly limited, but tocopheryl phosphate is preferable, and sodium tocopheryl phosphate is more preferable. The content is preferably 0.05 to 5% by mass, more preferably 0.1 to 2% by mass. If it is used within this range, it can be expected to have an effect of efficiently improving the transparency of the appearance and the stability over time while having a good feeling of use without being squeaky.
本発明に用いられるトコフェロール誘導体の市販品としては、例えば、「ビタミンＥリン酸ナトリウム（ＴＰＮａ）」（昭和電工株式会社製）等が挙げられる。 As a commercial item of the tocopherol derivative used for this invention, "Vitamin E sodium phosphate (TPNa)" (made by Showa Denko KK) etc. are mentioned, for example.
本発明で用いられるポリオキシエチレンソルビタン脂肪酸エステルは特に限定されないが、好ましくはポリオキシエチレンの平均付加モル数が２０である、ヤシ油脂肪酸ポリオキシエチレン（２０）ソルビタン、モノラウリン酸ポリオキシエチレン（２０）ソルビタン、モノステアリン酸ポリオキシエチレン（２０）ソルビタン、モノオレイン酸ポリオキシエチレン（２０）ソルビタン等が挙げられ、これらから１種又は２種以上を組み合わせて用いることができる。その含有量は、特に限定されないが、０．０５〜５質量％が好ましく、０．１〜２質量％がより好ましい。０．０５質量％よりも少ない場合には、外観の透明性が失われる場合があり、５質量％よりも多い場合には、使用感のみずみずしさが失われる場合がある。 The polyoxyethylene sorbitan fatty acid ester used in the present invention is not particularly limited. Preferably, the polyoxyethylene has an average addition mole number of 20, coconut oil fatty acid polyoxyethylene (20) sorbitan, polyoxyethylene monolaurate (20 ) Sorbitan, polyoxyethylene monostearate (20) sorbitan, polyoxyethylene monooleate (20) sorbitan, etc. can be used, and one or more of these can be used in combination. Although the content is not specifically limited, 0.05-5 mass% is preferable and 0.1-2 mass% is more preferable. When it is less than 0.05% by mass, the transparency of the appearance may be lost, and when it is more than 5% by mass, not only the feeling of use may be lost.
本発明に用いられるポリオキシエチレンソルビタン脂肪酸エステルの市販品としては、例えば、「ＮＩＫＫＯＬ ＴＬ−１０」（日本サーファクタント工業株式会社製）、「ＮＩＫＫＯＬ ＴＯ−１０」（日本サーファクタント工業株式会社製）、「ＮＩＫＫＯＬ ＴＳ−１０Ｖ」（日本サーファクタント工業株式会社製）等が挙げられる。 As a commercial item of the polyoxyethylene sorbitan fatty acid ester used for this invention, "NIKKOL TL-10" (made by Nippon Surfactant Industries Ltd.), "NIKKOL TO-10" (made by Nippon Surfactant Industries Ltd.), " NIKKOL TS-10V "(manufactured by Nippon Surfactant Co., Ltd.) and the like.
本発明の透明化粧料は、上記必須成分の他に、本発明の効果を損なわない質的量的範囲で、通常の化粧料に用いられる成分を含有しても良い。例えば、植物油、炭化水素油、エステル油、鉱物油等の油性成分、多価アルコール、高分子化合物、界面活性剤、粉体、色材、動植物抽出液、ビタミン、紫外線吸収剤、防腐剤、酸化防止剤、キレート剤、ｐＨ調整剤、香料、着色剤、美容成分等が挙げられ、上記成分から一種又は二種以上を組み合わせて用いることができる。 In addition to the above essential components, the transparent cosmetic of the present invention may contain components used in normal cosmetics within a qualitative and quantitative range that does not impair the effects of the present invention. For example, oily components such as vegetable oils, hydrocarbon oils, ester oils, mineral oils, polyhydric alcohols, polymer compounds, surfactants, powders, coloring materials, animal and plant extracts, vitamins, UV absorbers, preservatives, oxidation An inhibitor, a chelating agent, a pH adjuster, a fragrance, a colorant, a cosmetic ingredient, and the like can be mentioned. One or two or more of the above ingredients can be used in combination.
本発明の透明化粧料は、化粧料、医薬部外品、医薬品として使用可能である。また、その用途は、化粧水、透明ジェル、美容液、ボディローション等が挙げられる。その性状は、液状が好ましいが、水性増粘剤を添加して、粘性を付与した性状でも良い。さらに、その使用方法は、手や指を用いて顔や体に塗布する方法、噴射剤とともに容器に充填し、エアロゾルとして塗布する方法、不織布に含浸させて使用する方法等が挙げられる。 The transparent cosmetics of the present invention can be used as cosmetics, quasi drugs, and pharmaceuticals. Moreover, the use includes skin lotion, transparent gel, cosmetic liquid, body lotion and the like. The property is preferably liquid, but may be a property imparted with viscosity by adding an aqueous thickener. Furthermore, the usage method includes a method of applying to the face and body using hands and fingers, a method of filling a container with a propellant and applying it as an aerosol, a method of impregnating a nonwoven fabric, and the like.
本発明における透明の定義については以下の通りとした。島津製作所製の分光光度計（ＵＶ−１６０Ａ）を用いて波長６５０ｎｍの光の透過率を厚さ１０ｍｍの石英セルで測定し、透過率が９５．０％〜１００％であるとき透明であると定義した。ただし、ここでは水の透過率を１００％とした。 The definition of transparency in the present invention is as follows. Using a spectrophotometer (UV-160A) manufactured by Shimadzu Corporation, the transmittance of light having a wavelength of 650 nm is measured with a quartz cell having a thickness of 10 mm, and the transmittance is 95.0% to 100%. Defined. Here, the water permeability was set to 100%.
以下、本発明の透明化粧料の調製方法について詳細に説明する。 Hereafter, the preparation method of the transparent cosmetics of this invention is demonstrated in detail.
トコフェリルリン酸塩及び水溶性成分を水に溶解する（ａ部）。ユビキノンをポリオキシエチレンソルビタン脂肪酸エステル及び溶剤で加熱溶解する（ｂ部）。エタノール及びエタノールに可溶な成分を溶解し（ｃ部）、そこへｂ部を添加し混合する。その後、ｂ部及びｃ部の混合部をａ部に添加して撹拌することにより透明化粧料が得られる。 Tocopheryl phosphate and water-soluble components are dissolved in water (part a). Ubiquinone is dissolved by heating with polyoxyethylene sorbitan fatty acid ester and a solvent (part b). Dissolve ethanol and ethanol-soluble components (part c), add part b and mix. Then, a transparent cosmetic is obtained by adding and stirring the mixing part of b part and c part to a part.
以下に、実施例を挙げて、本発明を更に詳細に説明する。尚、これらは本発明を何ら限定するものではない。 Hereinafter, the present invention will be described in more detail with reference to examples. Note that these do not limit the present invention.
表１〜４に示す処方より実施例と比較例をそれぞれ調製し、ｐＨ測定、外観の透明性及び経時安定性、使用感（きしみ感のなさ、みずみずしさ）について評価した。以下、表中の数値は質量％を示す。 Examples and Comparative Examples were respectively prepared from the formulations shown in Tables 1 to 4, and evaluated for pH measurement, appearance transparency and stability over time, and feeling of use (no squeaky feeling, freshness). Hereinafter, the numerical value in a table | surface shows the mass%.
（製造方法）実施例１〜１３及び比較例１〜４
（１）ａ部を溶解する。
（２）ｂ部を加熱溶解した後、ｃ部と混合する。
（３）（１）に（２）を添加し、撹拌して化粧料を得た。
(Manufacturing method) Examples 1-13 and Comparative Examples 1-4
(1) Dissolve part a.
(2) After part b is heated and dissolved, it is mixed with part c.
(3) (2) was added to (1) and stirred to obtain a cosmetic.
（ｐＨ測定方法）
得られた化粧料を、２０℃の恒温槽にて２４時間保管した後、ガラス電極式水素イオン濃度計（堀場製作所製、Ｆ−５１）を用いて常法により行った。
(PH measurement method)
The obtained cosmetic was stored in a constant temperature bath at 20 ° C. for 24 hours, and then subjected to a conventional method using a glass electrode type hydrogen ion concentration meter (F-51, manufactured by Horiba, Ltd.).
（透明性評価方法）
得られた化粧料を、透明瓶に充填し、２０℃の恒温槽にて２４時間保管した後、外観検査を行い、下記の判断基準で評価した。
○：外観に濁りが無く透明である。
×：外観に濁り、或いは沈殿物が認められる。
(Transparency evaluation method)
The obtained cosmetic was filled in a transparent bottle and stored in a constant temperature bath at 20 ° C. for 24 hours, and then an appearance inspection was performed and evaluated according to the following criteria.
○: The appearance is not turbid and transparent.
X: The appearance is cloudy or precipitates are observed.
（経時安定性評価方法）
得られた化粧料を、透明瓶に充填し、５℃及び４０℃の恒温槽にて６か月保管し、３か月及び６か月後の外観変化を以下の基準により判定した。
◎：５℃、４０℃のいずれにおいても、６か月間変化は無く、外観に濁り、或いは沈殿物が無く透明である。
○：５℃、４０℃のいずれにおいても、３か月間変化は無く、外観に濁り、或いは沈殿物が無く透明であるが、６か月後では５℃及び／又は４０℃において、外観に濁り、或いは沈殿物が認められる。
×：５℃及び／又は４０℃において、３か月後で外観に濁り、或いは沈殿物が認められる。
(Time stability evaluation method)
The obtained cosmetic was filled in a transparent bottle, stored in a thermostatic bath at 5 ° C. and 40 ° C. for 6 months, and the appearance change after 3 months and 6 months was determined according to the following criteria.
A: No change at 6 ° C. for 6 months at both 5 ° C. and 40 ° C., and the appearance is turbid or transparent with no precipitate.
○: No change for 3 months at 5 ° C. or 40 ° C. and turbid in appearance, or transparent without precipitates, but turbid in appearance at 5 ° C. and / or 40 ° C. after 6 months Or a precipitate is observed.
X: At 5 ° C. and / or 40 ° C., the appearance becomes turbid after 3 months or precipitates are observed.
（使用感評価方法）
（１）きしみ感のなさ
女性専門パネル（２０名）による使用試験を実施し、きしみ感のなさについて、下記の基準に従って評価した。
◎：１８名以上が、きしみ感がないと判定した。
○：１４〜１７名が、きしみ感がないと判定した。
△：９〜１３名が、きしみ感がないと判定した。
×：きしみ感がないと判定した人が８名以下。
（２）みずみずしさ
女性専門パネル（２０名）による使用試験を実施し、みずみずしさについて、下記の基準に従って評価した。
◎：１８名以上が、みずみずしさを感じると判定した。
○：１４〜１７名が、みずみずしさを感じると判定した。
△：９〜１３名が、みずみずしさを感じると判定した。
×：みずみずしさを感じると判定した人が８名以下。
(Usage feeling evaluation method)
(1) Absence of squeaky A usage test was conducted by a female panel (20 persons), and the absence of squeaky was evaluated according to the following criteria.
A: 18 or more people judged that there was no squeaky feeling.
A: 14 to 17 persons determined that there was no squeaky feeling.
Δ: Nine to thirteen people determined that there was no squeaky feeling.
X: Eight or less people determined that there was no squeaky feeling.
(2) Water freshness A usage test was conducted by a female panel (20 people), and the water freshness was evaluated according to the following criteria.
A: 18 or more people judged that they felt fresh.
○: It was determined that 14 to 17 people felt fresh.
Δ: It was determined that 9 to 13 people felt freshness.
×: Eight or fewer people determined to feel fresh.
必須成分（Ａ）〜（Ｃ）を含有した化粧料（実施例１）は、外観の透明性及び経時安定性に優れ、また全ての使用感評価項目においても良好であり、本発明効果が得られた。一方、成分（Ｂ）又は成分（Ｃ）のどちらか一方を含有していない化粧料（比較例１、２）及び成分（Ｃ）の代わりに他の界面活性剤を含有した化粧料（比較例３、４）は、本発明効果を得ることができなかった。 The cosmetic (Example 1) containing the essential components (A) to (C) is excellent in the transparency of the appearance and the stability over time, and is good in all the usability evaluation items, and the effects of the present invention are obtained. It was. On the other hand, cosmetics that do not contain either component (B) or component (C) (Comparative Examples 1 and 2) and cosmetics that contain other surfactants instead of component (C) (Comparative Examples) In 3 and 4), the effect of the present invention could not be obtained.
成分（Ａ）ユビキノンを０．００１〜０．３質量％で含有した化粧料（実施例２〜５）は、いずれも外観の透明性及び経時安定性に優れ、また全ての官能評価項目においても良好であり、本発明効果が得られた。特に、成分（Ａ）ユビキノンの含有量が０．０１〜０．１質量％の化粧料（実施例３、４）では、全ての評価項目において格段に優れた評価結果であった。 The cosmetics (Examples 2 to 5) containing 0.001 to 0.3% by mass of component (A) ubiquinone are excellent in transparency of appearance and stability over time, and also in all sensory evaluation items. The effect of the present invention was obtained. In particular, in the cosmetics (Examples 3 and 4) in which the content of the component (A) ubiquinone was 0.01 to 0.1% by mass, the evaluation results were remarkably excellent in all evaluation items.
成分（Ｂ）トコフェロール誘導体を０．０５〜５質量％含有した化粧料（実施例６〜９）は、いずれも外観の透明性、経時安定性に優れ、また全ての使用感評価項目においても良好であり、本発明効果が得られた。特に、成分（Ｂ）トコフェロール誘導体の含有量が０．１〜２質量％の化粧料（実施例７、８）では、全ての評価項目において格段に優れた評価結果であった。 The cosmetics (Examples 6 to 9) containing 0.05 to 5% by mass of the component (B) tocopherol derivative are all excellent in transparency of appearance and stability over time, and good in all evaluation items for use feeling. Thus, the effect of the present invention was obtained. In particular, in the cosmetics (Examples 7 and 8) in which the content of the component (B) tocopherol derivative was 0.1 to 2% by mass, the evaluation results were remarkably excellent in all evaluation items.
成分（Ｃ）ポリオキシエチレン（２０）ソルビタン脂肪酸エステルを０．０５〜５質量％含有した化粧料（実施例１０〜１３）は、いずれも経時安定性に優れ、また全ての使用感評価項目においても良好であり、本発明効果が得られた。特に成分（Ｃ）ポリオキシエチレン（２０）ソルビタン脂肪酸エステルの含有量が０．１〜２質量％の化粧料（実施例１１、１２）では、全ての評価項目において格段に優れた結果であった。 The cosmetics (Examples 10 to 13) containing 0.05 to 5% by mass of component (C) polyoxyethylene (20) sorbitan fatty acid ester are all excellent in stability over time, and in all evaluation items for use feeling. And the effects of the present invention were obtained. Especially in the cosmetics (Examples 11 and 12) in which the content of the component (C) polyoxyethylene (20) sorbitan fatty acid ester was 0.1 to 2% by mass, the results were remarkably excellent in all evaluation items. .
以下に、本発明のその他の実施例を示す。尚、これら全ての実施例においても、外観の透明性、経時安定性、全ての使用感評価項目において優れた結果であり、本発明効果が得られた。 Other examples of the present invention will be shown below. In all of these examples, the results were excellent in the transparency of the appearance, the temporal stability, and all the usability evaluation items, and the effects of the present invention were obtained.
（実施例１４） 化粧水 ｐＨ７．５
含有成分 含有量（質量％）
（１）精製水 残余
（２）トコフェリルリン酸ナトリウム（成分Ｂ）※１ １．００
（３）ＡＭＰＤ ０．３０
（４）クエン酸 適量
（５）ＥＤＴＡ−４Ｎａ 適量
（６）グリチルレチン酸ジカリウム ０．０５
（７）ベタイン ０．５０
（８）グリシン ０．０１
（９）サクシニルアテロコラーゲン ０．０５
（１０）オタネニンジンエキス ０．０２
（１１）加水分解エラスチン ０．０３
（１２）ユビキノン（成分Ａ）※２ ０．０１
（１３）モノステアリン酸ポリオキシエチレン（２０）ソルビタン（成分Ｃ）※７
０．６０
（１４）エタノール ４．００
（１５）メチルパラベン ０．２０
（１６）香料 ０．０５
（１７）ＢＧ １０．００
（１８）グリセリン ５．００
（１９）ジグリセリン １．００
（２０）ポリアクリル酸Ｎａ ０．０２
[製法]
（１）〜（１１）を溶解する。（１２）及び（１３）を約８０℃で加熱溶解した後、（１４）〜（１６）と混合させ、（１）〜（１１）に（１２）〜（１６）を添加して撹拌する。（１７）〜（２０）を（１）〜（１６）に添加し、その後撹拌して化粧水を得た。
(Example 14) Lotion pH 7.5
Ingredient Content (mass%)
(1) Purified water residue (2) Sodium tocopheryl phosphate (component B) * 1 1.00
(3) AMPD 0.30
(4) Citric acid appropriate amount (5) EDTA-4Na appropriate amount (6) Dipotassium glycyrrhetinate 0.05
(7) Betaine 0.50
(8) Glycine 0.01
(9) Succinyl atelocollagen 0.05
(10) Ginseng extract 0.02
(11) Hydrolyzed elastin 0.03
(12) Ubiquinone (component A) * 2 0.01
(13) Polyoxyethylene monostearate (20) Sorbitan (component C) * 7
0.60
(14) Ethanol 4.00
(15) Methylparaben 0.20
(16) Fragrance 0.05
(17) BG 10.00
(18) Glycerin 5.00
(19) Diglycerin 1.00
(20) Polyacrylic acid Na 0.02
[Production method]
Dissolve (1) to (11). (12) and (13) are heated and dissolved at about 80 ° C., and then mixed with (14) to (16), and (12) to (16) are added to (1) to (11) and stirred. (17) to (20) were added to (1) to (16), and then stirred to obtain a lotion.
（実施例１５） 美容液 ｐＨ９．３
含有成分 含有量（質量％）
（１）精製水 残余
（２）トコフェリルリン酸ナトリウム（成分Ｂ）※１ ２．００
（３）ＡＭＰＤ １．８０
（４）クエン酸 適量
（５）ＥＤＴＡ−４Ｎａ 適量
（６）グリチルリチン酸ジカリウム ０．０１
（７）ユビキノン（成分Ａ）※２ ０．０２
（８）モノステアリン酸ポリオキシエチレン（２０）ソルビタン（成分Ｃ）※７
０．３０
（９）オレイン酸ポリオキシエチレン（２０）ソルビタン（成分Ｃ）※８ ０．５０
（１０）１，２−ペンタンジオール １．００
（１１）フェノキシエタノール ０．０５
（１２）エタノール ２．００
（１３）香料 ０．０２
（１４）ＢＧ ７．００
（１５）グリセリン ３．００
（１６）ＰＰＧ−１０メチルグルコース １．００
（１７）ヒアルロン酸Ｎａ ０．０１
[製法]
（１）〜（６）を溶解する。（７）〜（１０）を約８０℃で加熱溶解した後、（１１）〜（１３）と混合させ、（１）〜（６）に（７）〜（１３）を添加して撹拌する。（１４）〜（１７）を（１）〜（１３）に添加し、その後撹拌して美容液を得た。
(Example 15) Cosmetic liquid pH 9.3
Ingredient Content (mass%)
(1) Purified water residue (2) Sodium tocopheryl phosphate (component B) * 1 2.00
(3) AMPD 1.80
(4) Citric acid appropriate amount (5) EDTA-4Na appropriate amount (6) Dipotassium glycyrrhizinate 0.01
(7) Ubiquinone (component A) * 2 0.02
(8) Polyoxyethylene monostearate (20) Sorbitan (component C) * 7
0.30
(9) Polyoxyethylene oleate (20) Sorbitan (component C) * 8 0.50
(10) 1,2-pentanediol 1.00
(11) Phenoxyethanol 0.05
(12) Ethanol 2.00
(13) Perfume 0.02
(14) BG 7.00
(15) Glycerin 3.00
(16) PPG-10 methyl glucose 1.00
(17) Hyaluronic acid Na 0.01
[Production method]
Dissolve (1) to (6). (7) to (10) are heated and dissolved at about 80 ° C., and then mixed with (11) to (13), and (7) to (13) are added to (1) to (6) and stirred. (14) to (17) were added to (1) to (13) and then stirred to obtain a cosmetic liquid.
※１：ビタミンＥリン酸ナトリウム（ＴＰＮａ）：昭和電工株式会社製
※２：ユビデカレノン「カネカ」：株式会社カネカ製
※３：ＮＩＫＫＯＬ ＴＬ−１０：日本サーファクタント工業株式会社製
※４：ＮＩＫＫＯＬ ＨＣＯ−４０：日本サーファクタント工業株式会社製
※５：ＮＩＫＫＯＬ ＨＣＯ−６０：日本サーファクタント工業株式会社製
※６：レオドール ＴＷ−１２０：花王株式会社製
※７：ＮＩＫＫＯＬ ＴＳ−１０Ｖ：日本サーファクタント工業株式会社製
※８：ＮＩＫＫＯＬ ＴＯ−１０Ｖ：日本サーファクタント工業株式会社製
* 1: Vitamin E sodium phosphate (TPNa): Showa Denko Co., Ltd. * 2: Ubidecarenone "Kaneka": Kaneka Co., Ltd. * 3: NIKKOL TL-10: Nihon Surfactant Kogyo Co., Ltd. * 4: NIKKOL HCO-40 : Nihon Surfactant Kogyo Co., Ltd. * 5: NIKKOL HCO-60: Nihon Surfactant Kogyo Co., Ltd. * 6: Rheodor TW-120: Kao Co., Ltd. * 7: NIKKOL TS-10V: Nihon Surfactant Kogyo Co., Ltd. * 8: NIKKOL TO-10V: manufactured by Nippon Surfactant Co., Ltd.
本発明は、ユビキノン、トコフェロール誘導体及びポリオキシエチレンソルビタン脂肪酸エステルを含有することにより、アルカリ条件下であっても、ユビキノンの析出がなく経時安定性に優れ、さらには、きしみ感がなく、みずみずしい使用感を有する透明化粧料を提供することを可能とした。 The present invention contains ubiquinone, a tocopherol derivative and a polyoxyethylene sorbitan fatty acid ester, so that even under alkaline conditions, there is no precipitation of ubiquinone and excellent stability over time, and furthermore, there is no squeaky feeling and fresh use. It was possible to provide a transparent cosmetic having a feeling.
Claims (1)
（Ａ）ユビキノン ０．００１〜０．３質量％
（Ｂ）トコフェリルリン酸塩 ０．０５〜５質量％
（Ｃ）ポリオキシエチレンの平均付加モル数が２０であるポリオキシエチレンソルビタン脂肪酸エステル ０．０５〜５質量％ Containing the following components (A) ~ (C), a transparent cosmetic wherein der Rukoto least 7 pH.
(A) Ubiquinone 0.001-0.3 mass%
(B) Tocopheryl phosphate 0.05-5 mass%
(C) 0.05-5 mass% of polyoxyethylene sorbitan fatty acid ester whose polyoxyethylene average addition mole number is 20
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Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6200550B1 (en) * | 1998-12-11 | 2001-03-13 | Q-Pharma, Inc. | Oral care compositions comprising coenzyme Q10 |
| JP2003012492A (en) * | 2001-07-02 | 2003-01-15 | Noevir Co Ltd | Cosmetic |
| JP3740069B2 (en) * | 2002-02-08 | 2006-01-25 | 日本メナード化粧品株式会社 | Topical skin preparation |
| JP2006273814A (en) * | 2005-03-30 | 2006-10-12 | Naris Cosmetics Co Ltd | Coenzyme q10-containing water-based composition |
| TW200808333A (en) * | 2006-04-17 | 2008-02-16 | Kaneka Corp | Licorice polyphenol preparation |
| DE112007001469T5 (en) * | 2006-06-23 | 2009-06-04 | Ajinomoto Co., Inc. | Collagen Synthesis Promoter Containing Zinc as an Active Ingredient |
| JP2008239580A (en) * | 2007-03-28 | 2008-10-09 | Fujifilm Corp | Emulsion composition, and food and cosmetic containing the same |
| JP4341983B2 (en) * | 2007-12-07 | 2009-10-14 | 株式会社資生堂 | Topical skin preparation |
| JP2011207808A (en) * | 2010-03-30 | 2011-10-20 | Nippon Menaade Keshohin Kk | Antibacterial agent |
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