JP6447971B2 - A method for distinguishing the risk of stains - Google Patents

Description

  The present invention relates to a method for discriminating the risk of occurrence of spots or the like.

Skin pigmentation symptoms such as spots and buckwheat have a great influence on the appearance and appearance of the face, so there is a great interest in the prevention and improvement.
Conventionally, whitening agents with various mechanisms of action have been developed, and consumers can select cosmetics according to their preference and desired effect. In order to make the selection more suitable for each person and to support appropriate skin care, it has been proposed to predict the likelihood of spots and freckles. For example, the present inventor has previously developed a method for discriminating the occurrence probability of a spot or the like based on the fact that a mutation of a specific gene is correlated with the occurrence probability of a spot or buckwheat in Japanese (Patent Document 1). .

Japanese Patent No. 4,817,666

  Analysis of gene mutations may require complicated operations and time. Therefore, an object of this invention is to provide the discrimination method which can estimate the generation | occurrence | production risk of a spot etc. more simply and with high precision.

  As a result of diligent research, the present inventors have found that there are many mutations that correlate with a high probability of occurrence of spots or the like in a specific gene described in Patent Document 1 in the race (Jomon people) that first settled in the Japanese archipelago. It was found that there was a high possibility. As a result of further research, the present invention was completed by obtaining the knowledge that there is a correlation that stains and freckles tend to occur when the degree of physical characteristics of Jomon people is high.

That is, the present invention is as follows.
[1] A method for discriminating the risk of spot occurrence, characterized by using the Jomon score as an index.
[2] The Jomon score is one or more of Jomon character characteristic items selected from nasal bone height, facial sculpture depth, under-nose length, eye size, earwax, hair quality, wink, and eyelid The discrimination method according to [1], which is a judgment value.
[3] The discrimination method according to [1] or [2], further characterized by using age as an index.
[4] The discrimination method according to any one of [1] to [3], further comprising using an ultraviolet accumulated value as an index.
[5] The discrimination method according to any one of [1] to [4], wherein blood type is further used as an index. [6] The discrimination method according to any one of [1] to [5], wherein the discrimination of the risk of occurrence of spots is performed using an estimation formula obtained by multivariate analysis.
[7] One or two or more types of items including at least a Jomon score selected from the group consisting of a stain score, a Jomon score, an age, an ultraviolet ray accumulation value, and a blood type, which are performed on a plurality of persons. The discrimination method according to [6], which is an estimation formula calculated by applying the determination result to a logistic model of multivariate analysis.
[8] One or more items selected from the group consisting of the Jomon score, age, accumulated ultraviolet light value, and blood type of the subject to be identified, and the same items used for the calculation of the previous estimation formula The method according to [7], wherein the determination result is applied to the estimation formula to discriminate a stain occurrence risk.

  The present invention provides a method for easily and accurately discriminating the occurrence risk of spots and the like. This makes it possible to obtain useful information when selecting a cosmetic suitable for an individual, or during counseling regarding skin care or a makeup method.

  Hereinafter, the present invention will be described in detail. However, the mode of each item is not limited to the following description, and a case where a plurality of modes are arbitrarily combined is also included in the present invention.

The discrimination method of the present invention is characterized by using the Jomon score as an index. In this specification, the “Jomon score” refers to a degree that is applicable to the physical characteristics of the Jomon people.
The present inventor has found that there is a correlation between the degree applicable to the physical characteristics of the Jomon people and the likelihood of occurrence of spots and freckles. The discrimination method of the present invention is based on this new knowledge. For example, when the Jomon score is high, it is determined that the risk of spot generation is high, and when the Jomon score is low, it is determined that the risk of spot generation is low.

The Jomon score is usually expressed as a numerical value. The method for calculating the Jomon score is not particularly limited. For example, it is determined whether or not one or more physical items (Jomon character characteristic items) characteristic of the Jomon people correspond, and depending on the number and degree of the corresponding items. The determination value obtained by giving points or expressing the ratio of the number of corresponding items as a percentage can be used as the Jomon score. As an example, 1 type or 2 points or more can be given to one or more types of Jomon character characteristic items when a predetermined standard of each item is satisfied, and the total of points of all items can be used as the Jomon score.
Although the Jomon character characteristic items are not particularly limited, for example, nasal bone height, facial sculpture depth, under-nose length, eye size, earwax, hair quality, wink, and eyelid are preferable. In the discrimination method of the present invention, it is preferable to make a determination on one or more of the above-mentioned Jomon character characteristics items. From the viewpoint of further improving the accuracy of discrimination, three or more are more preferable, and five or more are more preferable.
The Jomon people's characteristic item is the National Museum document `` Jomon people's face and skeleton-Jomon people and Yayoi skeleton '' http://www2.edu.ipa.go.jp/gz2/k-kda1/k-kca1 /IPA-jyoumonjintoyayoijinnokokkaku.htm, “A book that understands Japanese roots (“ Japanese History of Reversal ”Editorial Department, Takarajimasha, 2008”, National Museum “Japanese Faraway Travel Exhibition” (2001), “Bone Archaeology” Science and body history (Katayama Kazumichi, Keibunsha, 2013) "and" Where did the Jomon people go? (Association of the northern Jomon differentiation, Intelligent Link, 2013) "," Jomon people from Did you come to? (Association of North Jomon differentiation, Intelligent Link, 2012) "" Archaeology and Sakai and Hayato (Takikawa Wataru, Doseisha, 2012) "" Japanese origin (Newton Press, 2009) ) "" The ancestors who became Japanese (Kenichi Shinoda, Japan Broadcasting Publishing Association, 2007) "examined the physical characteristics of Jomon people It was adopted.

Below, each said Jomon character characteristic item is demonstrated.
The “nasal bone height” refers to the height of the nose. For example, it is preferably represented by the distance from the plane passing through the nose point and the left and right inner eye corner points to the nose tip. It can be said that the higher the nasal bone, for example, the distance is 16.4 mm or more, further 16.9 mm or more, particularly 17.4 mm or more, which is closer to the characteristics of the Jomon people. Moreover, it may be represented by a value obtained by dividing the distance by height (ratio of the distance to height), and it can be said that the larger the ratio, the closer to the features of the Jomon people.
The distance value may be obtained by directly measuring the face with a human hand, or may be obtained by measuring using a three-dimensional image photographing analysis device or the like.
When reflecting in the Jomon score whether the determination applies to “nasal bone height”, for example, when the distance is 16.4 mm or more, 1 point is given, or the distance or the above in the measurement values of all measurement subjects 1 point can be awarded when the ratio is included in the top 50%. Note that the criteria for assigning points is not limited to one level. For example, one point may be given for 16.4 mm or more, and two points may be given for 17.4 mm or more. From the viewpoint of further increasing

“Face depth” refers to the degree of a three-dimensional feature, for example, the height of a dent or between eyebrows. For example, it is preferably represented by the average value of the distance from the plane passing through the nose point and the upper left and right eyebrow points to the upper end and the lower end of the black eye part of the left eye or right eye. The deeper the face is, for example, the distance is 4.4 mm or more, further 4.9 mm or more, and particularly 5.7 mm or more. Moreover, it may be represented by a value obtained by dividing the distance by height (ratio of the distance to height), and it can be said that the larger the ratio, the closer to the features of the Jomon people.
The distance value may be obtained by directly measuring the face with a human hand, or may be obtained by measuring using a three-dimensional image photographing analysis device or the like. When both the left and right are measured, the average value may be used as the measured value.
When reflecting in the Jomon score whether or not it is applicable to “the depth of sculpture of the face”, for example, when the distance is 4.4 mm or more, 1 point is given, or the distance in the measurement values of all measurement subjects Or 1 point can be awarded when the ratio is included in the top 50%. In addition, the reference | standard which gives a point is not restricted to one step, For example, it is good also as multiple steps, such as giving 1 point in the case of 4.9 mm or more, and giving 2 points in the case of 5.7 mm or more, and accuracy of discrimination. From the viewpoint of further increasing

“Nose length” refers to the length between the bottom of the nose and the lips. For example, it is preferably represented by the distance from the lower nose point to the upper end of the lips. As the length under the nose is shorter, for example, the distance is 16.6 mm or less, further 16.1 mm or less, particularly 15.0 mm or less. Moreover, it may be represented by a value obtained by dividing the distance by the height (ratio of the distance to the height), and it can be said that the smaller the ratio, the closer to the features of the Jomon people.
The distance value may be obtained by directly measuring the face with a human hand, or may be obtained by measuring using a three-dimensional image photographing analysis device or the like.
When reflecting in the Jomon score whether the “under nose length” is true, for example, when the distance is 16.6 mm or less, 1 point is given, or the distance or the ratio in the measurement values of all measurement subjects 1 point can be given when the lower 50% is included. In addition, the reference | standard which gives a point is not restricted to one step, For example, when 16.6 mm or less, 1 point is given, and when it is 15.0 mm or less, two points may be given, and it is good also as multiple steps, and the accuracy of discrimination. From the viewpoint of further increasing

“Eye size” refers to the width of the eye, the length of the eye, or the area of the eye. For example, it is preferably represented by the distance (lateral width of the eye) between the inner eye corner point and the outer eye corner point. It can be said that the larger the eyes are, for example, that the distance is 26.0 mm or more, further 26.4 mm or more, particularly 27.0 mm or more, closer to the characteristics of the Jomon people. Moreover, it may be represented by a value obtained by dividing the distance by height (ratio of the distance to height), and it can be said that the larger the ratio, the closer to the features of the Jomon people.
The distance value may be obtained by directly measuring the face with a human hand, or may be obtained by measuring using a three-dimensional image photographing analysis device or the like. When both the left and right are measured, the average value may be used as the measured value.
When reflecting in the Jomon score whether the “eye size” is true, for example, when the distance is 26.0 mm or more, 1 point is given, or the distance or 1 point can be awarded when the ratio is included in the top 50%. Note that the criteria for assigning points is not limited to one level. For example, one point may be given for 26.0 mm or more, and two points may be given for 27.0 mm or more. From the viewpoint of further increasing

“Earwax” refers to the nature of whether the earwax is wet (moist) or dry (bulky). If the earwax is a moist type, it can be said that it is close to the features of the Jomon people.
The determination of the type of earwax may be made by listening to the measurement subject through self-evaluation through a questionnaire, or may be determined visually by an observer.
When the determination as to whether or not “ear wax” is true is reflected in the Jomon score, for example, when the ear wax is a wet type, 1 point can be given. Note that the criteria for assigning points is not limited to one level. For example, one point may be given for the “moist moist type” and two points may be given for the “moist type”. This is preferable from the viewpoint of further improving accuracy.

“Hair quality” refers to the nature of whether the hair is combed or straight. If the hair is combed, it can be said that it is close to the characteristics of the Jomon people.
The hair quality may be determined by asking the person to be measured about the self-evaluation through a questionnaire, or by an observer by visual observation or the like.
When the determination of whether or not the “hair quality” is true is reflected in the Jomon score, for example, 1 point can be given in the case of comb hair. Note that the criteria for assigning points is not limited to one stage. For example, one point may be given in the case of “slightly hair”, and two points may be given in the case of “skin hair”. It is preferable from the viewpoint of further raising.

“Wink” refers to the ability to make a gesture that only crushes one eye. If only one eye can be crushed without changing the shape of the lips, it can be said that it is close to the characteristics of the Jomon people.
The determination of wink may be made by listening to the person to be measured about the self-evaluation through a questionnaire, or may be determined visually by an observer.
When the determination of whether or not “wink” is true is reflected in the Jomon score, for example, if both eyes can wink without changing the shape of their lips, 1 point can be awarded. Note that the criteria for assigning points is not limited to one stage. For example, one point may be given when only one eye is available, and two points may be given when both eyes are available. To preferred.

“Eyelid” refers to the property of double or single eyelids. A double eyelid is close to the characteristics of the Jomon people.
The eyelid may be determined by asking the person to be measured about the self-evaluation through a questionnaire or by an observer.
When the determination of whether or not “eyelid” is true is reflected in the Jomon score, for example, when both eyes have double eyelids, 1 point can be given. Note that the criteria for assigning points is not limited to one level. For example, one point may be given when only one eye has a double eyelid, and two points may be given when both eyes have a double eyelid. This is preferable from the viewpoint of further improving the accuracy.

The discrimination method of the present invention may further use age as an index in addition to the Jomon score, thereby further improving the accuracy of discrimination.
This is based on the finding that spots and buckwheat are likely to occur with aging. For example, when age is high, it contributes to the determination that the risk of occurrence of stains is large, and when age is low, it contributes to the determination that the risk of occurrence of stains is small, and is comprehensively distinguished together with the index of the Jomon score.
For the age, the value of the actual age may be used as it is, or the value obtained by dividing the 30s and 40s for each age may be used as the age score, or the order in which all the measurers are sorted in order of age may be used as the age score. Good.

In the discrimination method of the present invention, in addition to the Jomon score, an ultraviolet accumulated value may be used as an index, thereby further improving the accuracy of the discrimination. Note that the above-mentioned age may be used as an index.
This is based on the finding that as the accumulation of damage due to ultraviolet rays already exposed to the skin increases, spots and freckles are more likely to occur. For example, when the accumulation of damage is large, it contributes to the determination that the risk of occurrence of stains is large, and when it is small, it contributes to the determination that the risk of occurrence of stains is small, and is comprehensively distinguished together with the index of the Jomon score.
The ultraviolet accumulated value is a numerical value representing the accumulation of damage caused by ultraviolet rays already exposed to the skin, and can be represented, for example, by the difference in skin color between the ultraviolet exposed portion and the non-exposed portion. Specifically, for example, the difference in skin lightness (L value) between the face buccal surface and the forearm, or the forearm outside and the forearm inside, respectively measured using a color difference meter (CR-300, manufactured by Konica Minolta Co., Ltd.) The difference in skin lightness (L value) can be used as the UV accumulation score. Moreover, the difference of the said L value may be used as it is, and the order which rearranged the measured value of all the measurement subjects in order may be used as the ultraviolet ray accumulation score.

In addition to the Jomon score, the discrimination method of the present invention may further use blood type as an index, thereby further improving the accuracy of discrimination. In addition, you may use together with making age and / or a ultraviolet-ray accumulated value mentioned above into a parameter | index.
The inventor newly found that there is a correlation between the non-O type (A type, B type, and AB type) in the ABO blood group classification and the likelihood of occurrence of spots and freckles. Based on the findings. For example, in the case of non-O type (A type, B type, and AB type), it contributes to the determination that the risk of occurrence of the stain is large, and in the case of O type, it contributes to the determination that the risk of occurrence of the stain is small, and the Jomon score A comprehensive differentiation is made in conjunction with the above indicators.
When the blood type is scored and used as an index in this discrimination method, for example, in the case of non-O type (A type, B type, and AB type), it may be expressed as a numerical value such as 1 point.

  The risk of occurrence of spots estimated by the differentiation method of the present invention is the likelihood of occurrence of local pigmentation symptoms of skin including not only spots but also spots and freckles, and is usually expressed as a numerical value as odds. It is preferable to indicate the ratio. In addition, although the site | part of the skin in which a pigmentation symptom generate | occur | produces is not specifically limited, such as a face, an extremity, a neck part, a trunk | drum, etc., it distinguishes normally about the risk | occurrence | production of the spot on a face.

In the discrimination method of the present invention, the risk of occurrence of spotting is discriminated by measuring (determining) items to be indexed for the subject to be discriminated, and applying the obtained value to the estimation formula obtained by multivariate analysis. It is preferable to do.
The estimation formula can be created, for example, by measuring (determining) a stain score and a Jomon score on a measurement standard panel of a plurality of persons, and performing correlation analysis and regression analysis of the measurement (determination) results. . Specifically, for example, the calculation can be performed by applying the measurement (determination) to a logistic model of multivariate analysis and selecting a variable. In addition to the stain score and the Jomon score, one or more items selected from the group consisting of age, UV accumulation value, and blood type may also be used for the above-mentioned fitting. Since it can raise, it is preferable. As software used for analysis, software attached to the apparatus, commercially available software such as SPSS or SAS, or free software can be used, and is not particularly limited.
On the other hand, for the subject to be identified, it is one or more items selected from the group consisting of Jomon score, age, UV accumulation value, and blood type, and is the same as that used for the calculation of the previous term estimation formula Measure (determine) items. Then, the result is applied to the estimation formula to discriminate the risk of spot generation. The stain occurrence risk is expressed, for example, as a probability of entering a “stain-multiple group” or a “stain-small group” in a later-described stain score.

The “spot score” used to create the estimation formula refers to a numerical value of the status evaluation of the spot. For example, one or two or more observers visually observe two levels (1: low degree of stain) on the degree, density, size, etc. of spots and freckles on the basis of the actual face or facial photograph of the measurement subject. → 2: High degree of stain), preferably 3 or more (1: low degree of stain → 3: high degree of stain), more preferably 5 grades (1: low degree of stain → 5: high degree of stain) or more The average value can be used as a stain score. In addition, when the average value is included in the top 50% among all the measurement subjects, the “stain multiple group” may be used as the stain score 2, and when the average value is included in the lower 50%, the “spot small group” may be used as the stain score 1. . In addition, the grouping of the average values may be further multi-staged, and if it is preferably 3 stages or more, more preferably 5 stages or more, the discrimination accuracy can be further increased.

  The panel of the measurement standard for creating the estimation formula is not particularly limited, but preferably 30 or more, more preferably 50 or more, and even more preferably 100 or more, in order to ensure the accuracy of analysis. . Further, it is preferable that the age is distributed over a wide range such as in the 20s-60s. Moreover, although gender may be mixed, it is good also as only a man and a woman. It is preferable to arrange the races in yellow races.

Cosmetics can be selected based on the result of the risk of spot generation estimated by the discrimination method of the present invention. For example, when it is estimated that the risk of spot generation is high, a cosmetic material having a strong whitening effect or a melanin production suppressing effect is selected.
The result of the risk of occurrence of spots estimated by the discrimination method of the present invention can be a useful index even in counseling regarding skin care and makeup methods.

  EXAMPLES Hereinafter, although an Example demonstrates this invention still in detail, this invention is not limited to a following example, unless the summary is exceeded.

<Example 1> Correlation between Jomon score (8 items of Jomon character) and stain score (2 steps) (1) Measurement of Jomon score About 211 female subjects living in Akita in the 20s to 50s, Jomon character item 8 items (height of nasal bone, depth of sculpture of face, length of nose, eye size, earwax, hair quality, wink, and eyelid) were measured and judged. Specifically, the height of the nasal bone is determined by measuring the distance from the plane passing through the lower nose point and the left and right inner eye corner points to the nose apex, using a 3D image capture analysis device (VECTRA Face, manufactured by Integral Co., Ltd. 1 point was awarded when it was included in the top 50% of all subjects. The sculpture depth of the face is calculated by measuring the distance from the plane passing through the nose point and the left and right upper eyebrow points to the black eye part of the left eye or right eye using a 3D imaging analyzer, 1 point was awarded when the number of subjects included in the top 50%. The nose length was measured by measuring the distance from the nose point to the upper end of the lip using a three-dimensional image capturing / analyzing apparatus, and was given 1 point when the number was included in the lower 50% of all subjects. The size of the eye is measured by measuring the distance between the inner eye corner point and the outer eye corner point using a 3D image capturing / analyzing apparatus, and the average value of the left and right is calculated. 1 point was awarded in each case. Ear wax was awarded 1 point when a two-step questionnaire (moist type / dry type) was given to a subject and the answer was “moist type”. As for the hair quality, 1 point was given to a subject when a three-step questionnaire (skin hair / slightly hair / straight hair) was given to the subject and “skin hair” and “slightly hair” were answered. The wink was awarded to the subject when the right and left eyes were winked, and the observer made a visual determination. When both eyes were able to wink without changing the shape of the lips, 1 point was awarded. The eyelid was given 1 point when the observer visually observed the face of the subject and both eyes had double eyelids. The total of each of these 8 items was taken as the Jomon score.

(2) Measurement of stain score The stain score was determined for the subject. Specifically, the three observers have five levels of stains on the left and right faces, referring to the Apex Textbook (FY 2014) skin condition check reference photographic sheet based on the photograph of the subject's face. 1: Stain degree is low → 5: Stain degree is high), and the average value is calculated. When the average value is included in the upper 50% of the total number of subjects, the “stain multiple group” is score 2 and when it is included in the lower 50%, the “smear small group” is score 1.

(3) Analysis Correlation analysis was performed using JMP ver. 6.0 (SAS) using the Jomon score and stain score measured (determined). As a result, it was confirmed that the created model was valid and that there was a significant correlation between the Jomon score and the stain score (Table 1), and the Jomon score (Jomon character 8 items) was used as an index. It can be seen that the risk of occurrence can be estimated.

<Example 2> Correlation between Jomon score (Jomon character 1 item) and stain score (2 steps) (1) Measurement of Jomon score As in Example 1, determine 1 item (eyelid) of Jomon character And obtained the Jomon score.
(2) Measurement of spot score A spot score (two steps) was obtained in the same manner as in Example 1.
(3) Analysis Correlation analysis was performed in the same manner as in Example 1. As a result, the validity of the created model and the existence of a significant correlation between the Jomon score and the stain score were confirmed (Table 2), and the Jomon score (Jomon character 1 item) was used as an index. It can be seen that the risk of occurrence can be estimated.

<Example 3> Correlation between Jomon score (Jomon human characteristics 3 items) and stain score (2 stages) (1) Measurement of Jomon score As in Example 1, 3 items of Jomon character characteristics items (nasal bone height, The depth of sculpture of the face and the eyelid) were determined, and a Jomon score was obtained.
(2) Measurement of spot score A spot score (two steps) was obtained in the same manner as in Example 1.
(3) Analysis Correlation analysis was performed in the same manner as in Example 1. As a result, it was confirmed that the created model was valid and that there was a significant correlation between the Jomon score and the stain score (Table 3), and the Jomon score (Jomon characteristics 3 items) was used as an index. It can be seen that the risk of occurrence can be estimated.

<Example 4> Jomon score (Jomon character 8 items) and correlation between age and spot score (2 stages), and discrimination of the risk of occurrence of stain based on this (1) Measurement of Jomon score As in Example 1, Eight items of Jomon character characteristics items (nasal bone height, facial sculpture depth, under-nose length, eye size, earwax, hair quality, wink, and eyelid) were determined, and a Jomon score was obtained.
(2) Judgment of age About the subject, the answer of age was obtained by questionnaire and it was set as the score of age.
(3) Measurement of stain score A stain score (two steps) was obtained in the same manner as in Example 1.
(4) Analysis Correlation analysis was performed in the same manner as in Example 1. As a result, it was confirmed that the created model was valid, and there was a significant correlation between the Jomon score and age and the stain score (Table 4). Jomon score (Jomon character 8 items) and age It can be seen that the risk of spot generation can be estimated using the combination of
Therefore, by applying the Jomon score (Jomon character 8 items) and age to the logistic model of multivariate analysis and selecting variables according to AIC criteria, an estimation formula for the probability of entering the small stain group (spot score 1) was calculated. (Equation 1). If this estimation formula is applied to the Jomon score (8 items of Jomon human characteristics) and the age of the person to be identified, it is possible to distinguish the risk of spotting of the person to be identified.

<Example 5> Jomon score (Jomon character characteristics 3 items) and correlation between blood type and stain score (2 steps) (1) Measurement of Jomon score As in Example 1, 3 items of Jomon character characteristics items (nasal bones) The height, the sculpture depth of the features, and the eyelids) were determined, and a Jomon score was obtained.
(2) Blood type determination About the same subject, a blood type (ABO type) answer was obtained in a questionnaire, and in the case of non-O type (A type, B type, and AB type), blood type score of 1 and O type In some cases, the blood group score was 0.
(3) Creation of Jomon score + blood score The values obtained in (1) and (2) were added to obtain Jomon score + blood score. (4) Measurement of stain score Similar to Example 1, stain score (two steps) ).
(5) Analysis Correlation analysis was performed in the same manner as in Example 1. As a result, it was confirmed that the created model was valid, and there was a significant correlation between the Jomon score + blood score and the stain score (Table 5), and the Jomon score (Jomon character 3 items) and It can be seen that the risk of spot development can be estimated using the combination of blood types as an index.

<Example 6> Correlation between Jomon score (8 items of Jomon character) and stain score (5 levels) (1) Measurement of Jomon score As in Example 1, 8 items of Jomon character item (nasal bone height, The depth of face sculpture, length under the nose, eye size, earwax, hair quality, wink, and eyelid) were determined, and a Jomon score was obtained.
(2) Measurement of a spot score About the same test subject, three observers evaluated the spot in five stages in the same manner as in Example 1, and calculated an average value thereof. When the average value is included in the top 20% of all subjects within the top 20%, the score 5 is included, and when it is included within the top 20% and within 40%, the stain score 4 is included within the top 40% and within 60% Smudge score 3 was determined to be greater than 60% and included within 80%. Stain score 2 was determined to be greater than 80% and included within 100%.
(3) Analysis Correlation analysis was performed in the same manner as in Example 1. As a result, it was confirmed that the model created was valid, and there was a significant correlation between the Jomon score (8 Jomon characteristics) and the stain score (5 levels) (Table 6). It can be seen that the risk of spot generation can be estimated using (Jomon character 8 items) as an index.

<Example 7> Jomon score (Jomon character characteristic 8 items), correlation between age and ultraviolet accumulated value and stain score (5 levels) (1) Measurement of Jomon score As in Example 1, Jomon character characteristic item 8 Items (nasal bone height, facial sculpture depth, under-nose length, eye size, earwax, hair quality, wink, and eyelid) were determined, and a Jomon score was obtained.
(2) Measurement of UV accumulated value A color difference meter (CR-300, manufactured by Konica Minolta Co., Ltd.) was used to measure the difference in skin lightness (L value) between the outer side of the subject's forearm and the inner side of the forearm. When the measured value is included in the top 20% of all subjects in the top 20%, the UV accumulation score is 5, and when it is within the top 20% and within 40%, the UV accumulation score is 4 and above the top 40% and within 60% The UV accumulation score is 3 when it is included in the sample, the UV accumulation score is 2 when it is included in the range of more than 80% and within 80%, and the UV accumulation score is 1 when it is included in the range of more than 80% and 100%.
(3) Measurement of a spot score About the same test subject, three observers evaluated the spot in five stages as in Example 1, and calculated the average value. When the average value is included in the top 20% of all subjects within the top 20%, the score 5 is included, and when it is included within the top 20% and within 40%, the stain score 4 is included within the top 40% and within 60% Smudge score 3 was determined to be greater than 60% and included within 80%. Stain score 2 was determined to be greater than 80% and included within 100%.
(4) Analysis Correlation analysis was performed in the same manner as in Example 1. As a result, it was confirmed that the created model was valid, and there was a significant correlation between the Jomon score (Jomon character 8 items), age and UV accumulated value, and the score (5 levels). It can be seen that the risk of occurrence of spots can be estimated using the combination of (Table 7), Jomon score (Jomon character 8 items), age and UV accumulated value as an index.

  The present invention provides a method for easily and accurately discriminating the occurrence risk of spots and the like. Thus, useful information can be obtained when selecting a cosmetic suitable for an individual, or when counseling regarding skin care or a makeup method, which is industrially useful.

Claims (7)

A method for differentiating the risk of spot occurrence, characterized by using the Jomon score as an index ,
The Jomon score is one or more judgment values of Jomon character characteristic items selected from nasal bone height, facial sculpture depth, under-nose length, eye size, earwax, hair quality, wink, and eyelid. There is a differentiation method . The identification method according to claim 1, further comprising using age as an index. Furthermore, the ultraviolet-ray accumulated value is used as a parameter | index, The identification method of Claim 1 or 2 characterized by the above-mentioned. Furthermore, the discrimination method as described in any one of Claims 1-3 characterized by using a blood type as a parameter | index. The discrimination method according to any one of claims 1 to 4 , wherein the discrimination of the risk of occurrence of spots is performed using an estimation formula obtained by multivariate analysis. The estimated equation was performed with respect to a plurality of persons, Shimisukoa, and the Jomon score, age, ultraviolet accumulation value, and the determination of one or two or more items including at least the Jomon score is selected from the group consisting of blood The discrimination method according to claim 5 , which is an estimation formula calculated by applying the result to a logistic model of multivariate analysis. The differential target subject, the Jomon score, age, ultraviolet accumulation value, and the determination of the same items as used in the calculation of the previous SL estimation equation a one or two or more items selected from the group consisting of blood The method according to claim 6 , wherein a result is applied to the estimation formula to discriminate a risk of spot generation.