JP6364322B2 - Cosmetic or skin preparation - Google Patents

Description

  The present invention relates to an oil-in-water emulsified cosmetic or external preparation for skin, and more specifically, contains tranexamic acid, lysophospholipid, phospholipid and a specific oil that is liquid at 25 ° C., and has excellent sensory characteristics and stability over time. Further, the present invention relates to an oil-in-water emulsion type cosmetic or a skin external preparation.

Conventionally, in order to impart a whitening effect, an anti-inflammatory effect and the like to cosmetics and external preparations for skin (hereinafter referred to as cosmetics), tranexamic acid has been blended. (For example, see Patent Document 1 and Patent Document 2)
However, since tranexamic acid is a highly crystalline compound, when it is formulated in cosmetics, tranexamic acid itself crystallizes and precipitates, or is combined with other components and precipitates stably. Sometimes it was difficult. In particular, in oil-in-water emulsified cosmetics in which the aqueous phase is a continuous phase and the oily phase is dispersed as a discontinuous phase, the water-soluble polymer that breaks emulsified droplets with time due to tranexamic acid or imparts viscosity to the aqueous phase In some cases, it was difficult to obtain a stable oil-in-water emulsion, for example, the compounds aggregated to reduce viscosity and cause creaming.

Therefore, an external preparation for skin that suppresses crystal precipitation of tranexamic acid by combining a higher alcohol and a specific long-chain acylsulfonate type anionic surfactant and adjusting to a specific pH has been studied. (See Patent Document 3)
In addition, stable skin external preparations such as cream agents in which monocaprylic acid and an ester of a polyhydric alcohol and a nonionic surfactant are combined to prevent separation of an aqueous component and an oily component have been studied. (See Patent Document 4)

However, in the method of Patent Document 3, the pH of cosmetics and the like is limited to a specific range in the acidic range, and it is difficult to suppress crystal precipitation of tranexamic acid in products in a neutral range exceeding pH 6, which is widely used. In some cases, the degree of freedom of conversion may be narrowed, and the hardness of the cosmetic film derived from tranexamic acid may be felt after application to the skin, making it difficult to achieve sensory satisfaction.
Moreover, although the stability of cosmetics etc. can be ensured by the method of Patent Document 4, since the hardness of the cosmetic film derived from tranexamic acid is still felt on the skin after application, it may be difficult to obtain sensory satisfaction. there were.
Therefore, even if tranexamic acid is added, it is possible to obtain sufficient stability in the neutral range and a flexible cosmetic film that does not feel firm after application, and also has a feeling of penetration into the skin, moisture, and stickiness. There has been a demand for cosmetics that can satisfy sensory satisfaction during and after application.

JP-A-1-93519 JP 2008-100903 A JP 2011-84551 A JP 2011-16786 A

The object of the present invention is to solve the above-mentioned problems, and even if tranexamic acid is contained, it is not limited to the pH range, and particularly has a sufficient stability even in a neutral range exceeding pH 6, and feels hardness after application. It is an object of the present invention to provide an oil-in-water emulsified cosmetic or external preparation for skin that can provide a satisfactory cosmetic film, and can satisfy sensory satisfaction during and after application to the skin.

  As a result of intensive studies on the above problems, the inventors of the present invention have obtained an oil-in-water emulsion obtained by emulsifying tranexamic acid by combining four components of lysophospholipid, phospholipid and a specific liquid oil. Based on this finding, the present invention has been completed.

That is, the present invention includes the following components (A) to (D),
(A) tranexamic acid, (B) lysophospholipid, (C) phospholipid, (D) containing a liquid oil at 25 ° C selected from the group consisting of hydrocarbon oil and ester oil ,
The oil- in- water emulsified cosmetic , wherein the content ratio (B) / (C) of the component (B) and the component (C) is 1/100 to 10/1. It is a skin external preparation.
Moreover, as for this invention, the content mass ratio (B) / (C) of a component (B) and a component (C) is 1/10-5/1.

  Moreover, this invention is said cosmetics or the skin external preparation which contains a paste-form oil agent further at a component (E) 25 degreeC.

  In addition, the present invention provides the cosmetic or cosmetic composition further comprising one or more selected from component (F) a polyoxyalkylene derivative of glycerin, a polyoxyalkylene derivative of polyglycerin, or a polyoxyalkylene derivative of methyl glucoside. It is a skin external preparation.

The present invention also provides the cosmetic or skin external preparation described above, wherein the pH of the system is in a neutral range exceeding 6.

  Moreover, this invention is said cosmetics or skin external preparation whose molecular weight of a component (D) exists in the range of 200-1000.

  Moreover, this invention is the said cosmetics or skin external preparation characterized by the viscosity in 25 degreeC not exceeding 20,000 mPa * s.

  Furthermore, the present invention is the cosmetic or external skin preparation described above, wherein the maximum particle size of the emulsified droplets of the emulsified cosmetic preparation or external skin preparation does not exceed 1 μm.

The cosmetic or external preparation for skin of the present invention contains tranexamic acid in an oil-in-water emulsion type system, and has sufficient stability in a neutral range exceeding pH 6, and further, tranexam is applied to the skin after application. A flexible decorative film that does not feel the hardness derived from an acid can be obtained. In addition, it has a penetrating feeling on the skin at the time of application, the skin after application is not sticky, has a good feeling of moisture, and is extremely excellent as an oil-in-water emulsion type cosmetic or skin external preparation. Have quality.

Hereinafter, the present invention will be described in detail.
The component (A) tranexamic acid used in the present invention is a kind of amino acid represented by the chemical name: trans-4- (aminomethyl) cyclohexane-1-carboxylic acid. In addition to being known as a component having an anti-inflammatory effect, it may also be used as a hemostatic agent.

  In the cosmetic or skin external preparation of the present invention, the content of component (A) tranexamic acid is not particularly limited, but is preferably 0.1% by mass to 5% by mass from the viewpoint of the effectiveness of tranexamic acid and the stability of the preparation. 1 mass%-2 mass% are more preferable.

The lysophospholipid of component (B) used in the present invention is a modified phospholipid having one acyl group with respect to a phospholipid having two acyl groups. The lysophospholipid can be obtained, for example, by hydrolyzing the ester bond at the 2-position with phospholipase (hereinafter referred to as lysation). Examples of phospholipids used as raw materials for lysophospholipids include natural phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, sphingomyelin, egg yolk lecithin, soybean lecithin, sunflower lecithin, dilauroyl phosphatidylcholine, Synthetic phospholipids such as myristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, distearoyl phosphatidylcholine, dioleoylphosphatidylcholine, palmitoyl oleoylphosphatidylcholine, hydrogenated egg yolk lecithin, hydrogenated soybean lecithin, hydrogenated sunflower lecithin, hydrogenated phosphatidylserine Such as hydrogenated phospholipids It is possible. Various lysophospholipids can be obtained by hydrolyzing these phospholipids. Since lysophospholipid has only one acyl group derived from a fatty acid, which is a hydrophobic group, it has a chemical property different from that of phospholipid, such as a higher HLB and higher hydrophilicity than phospholipid.

In addition, lysophospholipids may contain hydrocarbon chains derived from unsaturated fatty acids in their structure, but the unsaturated part of these hydrocarbon chains is oxidized by light and oxygen, causing coloration, off-flavor generation, etc. May be reduced. Therefore, in order to suppress such quality deterioration, there is a hydrogenated lysophospholipid that is hydrogenated to an unsaturated portion to be a saturated hydrocarbon. In the present invention, the lysophospholipid of component (B) includes both lysophospholipids to which unsaturated fatty acids are bound and hydrogenated lysophospholipids. From the viewpoint of suppressing coloration and odor changes over time, hydrogenated soybean lysolin. Hydrogenated lysophospholipids such as lipids and hydrogenated egg yolk lysophospholipids are more preferred, and hydrogenated soybean lysophospholipids are particularly preferred.

Furthermore, in the present invention, the lysophospholipid of component (B) may contain a plurality of types of lysophospholipids such as lysophosphatidylcholine and lysophosphatidylethanolamine, and particularly preferably contains lysophosphatidylcholine essentially. In this case, the content of lysophosphatidylcholine is preferably 15% by mass or more in the component (B) from the viewpoint of emulsion stability, and more preferably 20% by mass to more. Such a thing can be suitably obtained especially in hydrogenated soybean lysophospholipid.

In the present invention, the lysophospholipid of component (B) may be used singly or in combination of two or more, and the content is not particularly limited, but is preferably cosmetic for obtaining a good emulsion. 0.01 mass% to 10 mass%, more preferably 0.05 mass% to 5 mass%, and particularly preferably 0.1 mass% to 1 mass% with respect to the total amount of the material.

The phospholipid of component (C) used in the present invention is not particularly limited as long as it has a phosphate ester moiety, and may be a natural phospholipid or a synthetic phospholipid, and these phospholipids are hydrogenated. Hydrogenated phospholipids may also be used. Examples of natural phospholipids include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, sphingomyelin, egg yolk phospholipid, soybean phospholipid, and synthetic phospholipids such as dilauroyl Examples thereof include phosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, dioleoylphosphatidylcholine, palmitoyl-oleoylphosphatidylcholine and the like. Examples of the hydrogenated phospholipid include hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, hydrogenated phosphatidylcholine, hydrogenated phosphatidylserine, and the like. Can be mentioned. The phospholipid of component (C) may be used alone or in combination of two or more.

In the present invention, the content of the component (C) is not particularly limited, but in the combination with the component (B) described above, it is preferable to improve the emulsion stability at a high temperature of 40 ° C. to 50 ° C. It is 0.01 mass%-10 mass% with respect to whole quantity, etc., More preferably, it is 0.1 mass%-5 mass%, Most preferably, it is 0.3 mass%-2 mass%.

  In the present invention, the content mass ratio (B) / (C) of the component (B) and the component (C) is preferably in the range of 1/100 to 10/1, more preferably 1/10 to 5/1. Particularly preferably, it is in the range of 1/3 to 2/1. Emulsification stability within the range of 1/100 to 10/1, especially emulsification stability at a high temperature of 40 ° C. to 50 ° C., and a low viscosity that does not exceed 20,000 mPa · s at 25 ° C. Even in the case of liquid cosmetics having a low viscosity such as lotion, especially emulsified cosmetics containing electrolytes such as vitamin C derivative salts, etc. Indicates. Needless to say, better stability over time is shown if it is in a more preferable range, and even better stability is shown if it is in a particularly preferable range.

As described above, lysophospholipids are obtained by lysolysis of phospholipids. In the present invention, the lysophospholipid of component (B) indicates a lysozyme. Accordingly, when a phospholipid / lysophospholipid mixture whose lysolysis rate (ratio of lysophospholipids in the total phospholipids) is not 100% is used as a raw material, the unlyzed phospholipid is a component of the present invention. Corresponds to (C).

The oil agent that is liquid at 25 ° C. selected from the group consisting of the hydrocarbon oil and ester oil of component (D) used in the present invention is not particularly limited, and is a hydrocarbon that is liquid at 25 ° C. that can be used in cosmetics and skin external preparations. Any oil or ester oil can be used. Regardless of the origin of the component oil (D), such as animal oil, vegetable oil, and synthetic oil, hydrocarbon oils include, for example, liquid paraffin, heavy liquid isoparaffin (hydrogenated polyisobutene), light liquid isoparaffin, dodecane, isododecane, tetradecane, and isotetradecane. Hexadecane, isohexadecane, squalane, synthetic squalane, vegetable squalane, polyisobutylene, polybutene and the like. The ester oil is a liquid oil containing an ester group, such as jojoba oil, cetyl 2-ethylhexanoate, isononyl isononanoate, isotridecyl isononanoate, isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, isononanoic acid Isotridecyl, ethyl oleate, glyceryl tri-2-ethylhexanoate, propylene glycol dicaprate, neopentyl glycol dicaprate, polyglyceryl triisostearate, glyceryl tribehenate, diisostearyl malate, ethylhexyldimethyl p-aminobenzoate, Ethyl hexyl salicylate, ethyl hexyl methoxycinnamate, tocopherol acetate, olive oil, castor oil, mink oil, macadamia nut oil, meadow foam oil Camellia oil, rose hip oil, rice bran oil can be exemplified avocado oil.

In the present invention, as the component (D), a hydrocarbon oil or ester oil having a molecular weight of 200 to 1000 is particularly preferable, and an oil-in-water emulsion type makeup with a better feeling of the back skin such as a moist feeling after application and non-stickiness. Fees etc. can be obtained. Component (D) having a molecular weight of 200 to 1000 includes, for example, isohexadecane, light liquid isoparaffin, liquid paraffin, heavy liquid isoparaffin, squalane, synthetic squalane, vegetable squalane, propylene glycol dicaprate, propylene glycol dicaprylate , Neopentyl glycol dicaprate, isononyl isononanoate, isotridecyl isononanoate, cetyl 2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, polyglyceryl-2 triisostearate, ethylhexyl methoxycinnamate, α-olefin oligomer (hydrogenated) Polydecene) and the like. The molecular weight value can be obtained as the sum of the atomic weights of the atoms constituting the molecule based on the chemical structural formula of the molecule of the above component. Light liquid isoparaffin, liquid paraffin, heavy liquid isoparaffin, α-olefin oligomer, etc. In the case of a mixture of components having different molecular weights, the carbon number distribution of these components is obtained, and the component whose value converted to the molecular weight of each component falls within the range of 200 to 1000 is 90% by mass or more of the mixture. If there is, it is assumed that it is a hydrocarbon oil or ester oil having a molecular weight of 200 to 1000 in the present invention. The light liquid isoparaffin, liquid paraffin, heavy liquid isoparaffin, and α-olefin oligomer listed in the quasi-drug raw material standard all correspond to the component (D) of the present invention.

In the present invention, the content of the component (D) is not particularly limited, but is preferably 0.1% by mass to 80% with respect to the total amount of the cosmetic or the external preparation for skin, as an amount that can sufficiently realize the skin effect of the component (D). % By mass, more preferably 0.5% by mass to 50% by mass, and particularly preferably 1% by mass to 20% by mass.

In the present invention, in addition to the above components, the addition of a paste-like oil agent at 25 ° C. of component (E) improves skin familiarity (adhesion feeling) at the time of application, and further improves the penetration feeling and moisture feeling. Therefore, it is preferable. Here, the pasty oil agent has a viscosity at 25 ° C. of 10,000 mPa · s or more measured by a Brookfield type rotational viscometer and exceeds a measurement limit of 100,000 mPa · s of the viscometer. -K-2220 conformity, consistency meter, use of 30 g aluminum cone, value after 5 seconds of dropping) refers to an oil agent with a value greater than 150 (soft). In the present invention, an oil that does not flow at 25 ° C. is particularly preferable. The oil of component (E) is not particularly limited as long as it is in a paste form at 25 ° C. Any oil can be used as long as it is a paste oil that can be used in cosmetics and external preparations for skin. Examples of the component (E) include dipentaerythritol fatty acid (hydroxystearic acid / stearic acid / rosin acid) ester, petrolatum, monostearic acid hydrogenated castor oil, monohydroxystearic acid hydrogenated castor oil, cholesteryl hydroxystearate, hydroxystearic acid Phytosteryl acid, phytosteryl oleate, N-lauroyl-L-glutamic acid-di (cholesteryl behenyl octyldodecyl), N-lauroyl-L-glutamic acid-di (phytosteryl behenyl octyldodecyl), dimerlinoleic acid (phytosteryl / Isostearyl / cetyl / stearyl / behenyl), alkoxy-modified silicone, alkyl-modified silicone, and the like. Fatty acid (hydroxystearic acid / stearic acid / rosin acid) ester, cholesteryl hydroxystearate, phytosteryl hydroxystearate, phytosteryl oleate, shea butter, N-lauroyl-L-glutamic acid-di (cholesteryl behenyl octyldodecyl), N It is more preferable to use -lauroyl-L-glutamic acid-di (phytosteryl, behenyl, octyldodecyl).

A component (E) can be used individually by 1 type or in combination of 2 or more types, Although the content is not specifically limited, 0.01 mass%-10 mass% are preferable, 0.05 mass%- 5 mass% is more preferable, and 0.1 mass%-2 mass% are especially preferable.

In the present invention, by containing a polyoxyalkylene derivative of glycerin, a polyoxyalkylene derivative of polyglycerin or a polyoxyalkylene derivative of methyl glucoside as the component (F), the permeation feeling and moisture feeling on the skin are further improved. . Here, the polyoxyalkylene derivative is preferably an ether compound obtained by addition polymerization of alkylene oxide to glycerin, polyglycerin or methyl glucoside. Specific examples of the component (F) include polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxypropylene polyglyceryl ether, polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, and the like. Of these, polyoxyethylene glyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene methyl glucoside or polyoxypropylene methyl glucoside having an addition mole number of alkylene oxide of 2 to 50 is particularly preferred.

A component (F) can be used individually by 1 type or in combination of 2 or more types, The content is not specifically limited, However, 0.1 mass%-30 mass% are preferable, 1 mass%-10 mass % Is more preferable.

The cosmetic or external preparation for skin of the present invention does not limit the pH of the system. However, the cosmetic or the external preparation of the present invention has sufficient stability and flexibility of the cosmetic film on the back skin at a pH in the neutral range exceeding 6, especially around pH 7. The effect can be enjoyed satisfactorily and is particularly preferable.

In the cosmetic or skin external preparation of the present invention, when the viscosity (25 ° C.) exceeds 20,000 mPa · s as measured with a Brookfield rotary viscometer, it becomes difficult to discharge from the discharge port of the pump-type dispenser container. Tend. The pump-type dispenser container is preferred because it is easy to handle and the discharge amount can be easily adjusted, and is also preferred for the cosmetics of the present invention, but for smooth discharge from the pump discharge port. The viscosity (25 ° C.) of the cosmetics of the present invention is preferably a relatively low viscosity that does not exceed 20,000 mPa · s.

The method for producing the cosmetic or the external preparation for skin of the present invention can also be processed using a high-pressure emulsifier such as a microfluidizer. By using a high-pressure emulsifier, for example, a low-viscosity emulsion-type cosmetic such as 1 mPa · s to 1,000 mPa · s (Brookfield rotary viscometer) at 25 ° C. can be applied to the skin. Sometimes it is possible to obtain a fresh feeling and a high penetration into the skin, which is preferable. When such a low-viscosity oil-in-water emulsified cosmetic is used, the average particle size of the emulsified droplets should not exceed 1 μm in order to improve the emulsion stability in the low viscosity region. Preferably, it is more preferable to set it as 0.01 micrometer-0.8 micrometer. Furthermore, it is particularly preferable that the maximum particle size of the emulsified droplets does not exceed 1 μm. The average particle diameter of the emulsified droplets can be determined by measurement using, for example, a Coulter counter (manufactured by Beckman Coulter, Inc .: submicron particle analyzer N5). The maximum particle size of the emulsified droplets can be determined with the same measuring device. The presence or absence of a particle size exceeding 1 μm can be examined by visual observation with a microscope using, for example, a slide glass with a scale. it can.

The cosmetic or the external preparation for skin of the present invention can be blended with other components that are blended with the normal cosmetic or external preparation for skin within the range not impeding the effects of the present invention. As other components, for example, the following components which are not included in the components (A) to (F) of the present invention, that is, solid oil, vegetable fat, dimethyl silicone, high molecular weight silicone, amino-modified silicone , Polyoxyalkylene-modified silicone, fluorine-modified silicone, polyhydric alcohol-modified silicone, monohydric lower alcohol, polyhydric alcohol, higher alcohol, higher fatty acid, organic powder, inorganic powder, water-soluble polymer, film forming agent, shade Ionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, aqueous thickeners, oily gelling agents, organically modified clay minerals, water-swelling clay minerals, thickening polysaccharides , Oil-based resin, UV absorber, UV screening agent, antiseptic, antibacterial agent, anti-inflammatory agent, fragrance, antioxidant, pH adjuster, chelating agent, water-soluble vitamins, oil-soluble vitamin S, ceramides, amino acids, mucopolysaccharides, plant extracts, can be blended vegetable fats like.

The cosmetics or skin external preparations of the present invention are skin cosmetics such as lotions, emulsions, creams, eye creams, cosmetics, massages, packs, hand creams, body creams, cleansings, and scalp cares. Or as a quasi-drug. The method of application to the skin is not limited, but the method of directly applying the cosmetic or the like to the skin by hand or finger, the method of applying it by impregnating a non-woven fabric, etc. And a method of spraying on the skin and applying to the skin, and a method of storing in a non-gas type pump spray container and spraying on the skin.

EXAMPLES Next, although an Example is given and this invention is demonstrated still in detail, this invention is not limited by these.

(Invention products 1-7 and comparative products 1-6: oil-in-water emulsified lotion)
An oil-in-water emulsified lotion was prepared by the composition shown in Table 1 and the following production method, and each sample was evaluated and judged by the following evaluation method. The results are also shown in Table 1.

Note 1: LP70H (Nippon Seika Co., Ltd.)
Note 2: Resinol S-10 (Nikko Chemicals)
Note 3: KLEAROL WHITE MINAL OIL (SONNEBORN, LLC)
Note 4: Pearl Lureme 18 (manufactured by NOF Corporation)
Note 5: Cosmall 168ARV (Nisshin Oillio Group)

(Production method)
A: Components (2) to (5) and components (14) and (15) are heated to 70 ° C. and mixed uniformly.
B: Components (6) to (11) and component (19) are heated to 70 ° C. and mixed uniformly.
C: B is added to A and a gel is prepared at 70 ° C.
D: A part of the component (20) heated to 70 ° C. is added to C and emulsified.
E: D is cooled to 35 ° C. and treated with a microfluidizer.
F: Components (1), (12), (13), (16), and (17) are dissolved in the remainder of the component (20), and E is added and mixed uniformly.
G: The component (18) was added to F and the pH was adjusted to 7. Thus, an oil-in-water emulsified lotion having no emulsified droplets with a particle diameter exceeding 1 μm within the range visually observed using a microscope was obtained.

(Evaluation method)
Each sample was used by 10 professional panels, and each evaluation of penetration feeling when applied to skin, softness of makeup film (inhibition effect on hardness), moisture feeling of applied skin, and non-stickiness The items were scored according to the following (b) 5-step evaluation criteria. And the average value of the score of all the panels was determined in accordance with the following (b) 4-step criteria. The stability over time was determined by the following (c) four-step criteria after each sample was left in a high temperature environment of 40 ° C. for one month, and the presence / absence and degree of change were visually confirmed. .

(B) Five-level evaluation criteria (score): (Evaluation)
5 points: 4 points felt strongly: 3 points felt: 2 points felt a little: 1 point not felt so much: Not felt at all

(B) Four-step criteria (average score): (Judgment)
4.5 or more: ◎
3.5 or more and less than 4.5: ○
2.5 or more and less than 3.5: △
Less than 2.5: ×

(C) 4-step criteria (degree of change after 40 ° C, 1 month): (Judgment)
No change and no problem: ◎
There is very little creaming: ○
Clearly there is creaming: △
Separated: ×

  As is apparent from the results in Table 1, the oil-in-water emulsified lotions of the products 1 to 7 of the present invention have a penetrating feeling when applied to the skin, the softness of the cosmetic film, the moist feeling of the skin after application, and no stickiness. It has good results in all items of stability over time, does not feel the hardness derived from tranexamic acid, has sufficient quality even in the neutral range of pH 7, and has excellent quality. Was proved. On the other hand, comparative products 1 and 2 which do not use lysophospholipid and phospholipid together, and comparative products 3 and 4 emulsified with other nonionic surfactants or anionic surfactants without using lysophospholipids or phospholipids The desired stability over time could not be obtained, and the hardness of the cosmetic film derived from tranexamic acid could not be sufficiently eliminated, so that a flexible cosmetic film could not be obtained. Moreover, the comparative product 5 using the oil agent other than the component (D) and the comparative product 6 not containing the component (D) do not have a moist feeling of the back skin, and good results are obtained even in the sense of penetration and non-stickiness. There wasn't.

(Invention product 8)
An oil-in-water emulsion type emulsion was prepared by the following composition and production method.
(Component) ... (mass%)
1. Hydrogenated egg yolk lysophospholipid 1
2. Hydrogenated soybean phospholipid 2
3. Tocopherol acetate ... 0.1
4). Ethyl oleate 2
5. Cetyl 2-ethylhexanoate 5
6). Cholesteryl hydroxystearate 1
7). N-lauroyl-L-glutamic acid-di (phytosteryl, behenyl, octyldodecyl) 1
8). Liquid paraffin (Note 3) 5
9. Setanol 1
10. Lipophilic glyceryl monostearate: 0.5
11. Propylene glycol ... 10
12 Glycerin ... 10
13. Diglycerin 5
14 Polyoxyethylene (10E.O.) methyl glucoside 5
15. Tranexamic acid 2
16. Sodium pyrosulfite 0.01
17. Sodium monohydrogen phosphate ... 0.1
18. Sodium dihydrogen phosphate ... 0.1
19. Preservative: appropriate amount 20. N-stearoyl-sodium L-glutamate 0.1
21. Ethanol 5
22. Carboxyvinyl polymer ... 0.1
23. Sodium hydroxide 0.03
24. Sodium hyaluronate ... 0.1
25. Perfume ... 0.1
26. Purified water

(Production method)
A: Components (1) to (13) are dissolved by heating at 70 ° C.
B: Components (20) and (26) are heated to 70 ° C., added to A and emulsified.
C: Components (14) to (19) and components (21) to (24) are added to B and mixed.
D: C was cooled and component (25) was added to obtain an emulsion.

The emulsion of the product 8 of the present invention did not feel the hardness derived from tranexamic acid on the skin after application, had a sense of penetration into the skin and a moist feeling, and had excellent quality with little stickiness. Further, separation and creaming were not observed over time, and the stability was excellent.

(Invention product 9)
A cream was prepared by the following composition and production method.
(Component) ... (mass%)
1. Hydrogenated soybean lysophospholipid ... 1
2. Cholesterol complexed hydrogenated soybean phospholipid (Note 6) 1
3. Squalane ... 5
4). Heavy liquid isoparaffin 2
5. Neopentyl glycol dicaprate 5
6). Glyceryl tri-2-ethylhexanoate 5
7). Phytosteryl oleate 1
8). Shea fat ...... 1
9. Ceramide-2 ... 0.01
10. Cetostearyl alcohol ・ ・ ・ 3
11. Behenyl alcohol 2
12 Dipropylene glycol 20
13. Monooleic acid polyoxyethylene sorbitan ... 0.5
14 Sorbitan sesquioleate ... 0.5
15. Polyoxypropylene (10P.O.) methyl glucoside 5
16. Tranexamic acid 2
17. Sodium pyrosulfite 0.01
18. Sodium monohydrogen phosphate ... 0.1
19. Sodium dihydrogen phosphate ... 0.1
20. Preservative: appropriate amount 21. Acrylic acid / Acroyldimethyltaurine sodium copolymer 1
22. Hydroxypropyl methylcellulose ... 0.1
23. L-Serine 0.1
24. L-Arginine ... 0.1
25. Ascorbic acid 2-glucoside ... 0.1
26. Purified water: remaining amount Note 6: Contains 80% by mass of hydrogenated soybean phospholipid

(Production method)
A: Components (1) to (14) are dissolved by heating at 70 ° C.
B: The component (26) is heated to 70 ° C., added to A and emulsified.
C: B was cooled, and components (15) to (25) were added and mixed to obtain a cream.

The cream of the product 9 of the present invention did not feel the hardness derived from tranexamic acid on the skin after application, had a penetration feeling into the skin and a moist feeling, and had excellent quality with little stickiness. Further, separation and creaming were not observed over time, and the stability was excellent.

(Invention product 10)
Sunscreen was prepared by the following composition and manufacturing method.
(Component) ... (mass%)
1. Hydrogenated soybean lysophospholipid ... 0.85
2. Phytosterol complex hydrogenated soybean phospholipids (Note 7) 0.5
3. Stearic acid 0.5
4). Light liquid isoparaffin 5
5. Isohexadecane 5
6). Propylene glycol dicaprate 5
7). Ethyl hexyl methoxycinnamate 5
8). Diethylaminohydroxybenzoyl hexyl benzoate 5
9. Dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) ... 1
10. Stearyl alcohol ... 2
11.1,3-butylene glycol 2
12 Dipropylene glycol 20
13. Polyoxypropylene (9E.O.) diglyceryl ether ... 10
14 Sodium hydroxide ... 0.1
15. Tranexamic acid 2
16. Sodium pyrosulfite 0.01
17. Sodium monohydrogen phosphate ... 0.1
18. Sodium dihydrogen phosphate ... 0.1
19. Preservative: appropriate amount 20. Alkyl-modified carboxyvinyl polymer ... 0.2
21. Xanthan gum ... 0.1
22. Dimethicone-treated fine particle titanium oxide 5
23. Perfume ... 0.1
24. Purified water
Note 7: Contains 85% by mass of hydrogenated soybean phospholipid

(Production method)
A: Components (1) to (14) are dissolved by heating at 70 ° C.
B: The component (24) is heated to 70 ° C., added to A and emulsified.
C: B was cooled, and components (15) to (23) were added and mixed to obtain a sunscreen.

The sunscreen of the product 10 of the present invention did not feel the hardness derived from tranexamic acid on the skin after application, had a penetration feeling into the skin and a moist feeling, and had excellent quality with little stickiness. . Further, separation and creaming were not observed over time, and the stability was excellent.

(Invention product 11)
A lotion was prepared by the following composition and production method.
(Component) ... (mass%)
1. Hydrogenated soybean lysophospholipid ... 0.1
2. Hydrogenated soybean phospholipid ... 0.3
3. Glycerin 5
4.1,3-Butylene glycol ... 10
5. Rice bran oil ... 0.3
6). Meadow foam oil 0.3
7). Olive squalane (Note 8) 0.4
8). Monostearic acid hydrogenated castor oil ... 0.1
9. Polyoxyethylene (4E.O.) lauryl ether phosphoric acid 0.01
10. Polyoxyethylene (10E.O.) methyl glucoside 0.5
11. Polyoxypropylene (14 PO) diglyceryl ether 0.5
12 Tranexamic acid 1
13. Sodium pyrosulfite 0.01
14 Sodium monohydrogen phosphate ... 0.1
15. Sodium dihydrogen phosphate ... 0.1
16. Preservatives-appropriate amount 17. Quince Seed Extract 1
18. Rose water ... 10
19. Dipotassium glycyrrhizinate ... 0.01
20. Perfume ... 0.01
21. Purified water
Note 8: Plant-based squalane

(Production method)
A: Components (1) to (4) are heated to 70 ° C. and mixed uniformly.
B: Components (5) to (9) and component (20) are heated to 70 ° C. and mixed uniformly.
C: B is added to A and a gel is prepared at 70 ° C.
D: A part of the component (21) heated to 70 ° C. is added to C and emulsified.
E: D is cooled to 35 ° C. and treated with a microfluidizer.
F: Components (10) to (19) are dissolved in the remainder of the component (21), E is added and mixed uniformly, and emulsified droplets having a particle diameter exceeding 1 μm within the range of visual observation using a microscope. A lotion that does not have was obtained.

The lotion of the product 11 of the present invention did not feel the hardness derived from tranexamic acid on the skin after application, had a penetrating and moist feeling on the skin, and had excellent quality with little stickiness. Further, separation and creaming were not observed over time, and the stability was excellent.

Claims (8)

The following components (A) to (D),
(A) tranexamic acid, (B) lysophospholipid, (C) phospholipid, (D) containing a liquid oil at 25 ° C selected from the group consisting of hydrocarbon oil and ester oil ,
The oil- in- water emulsified cosmetic , wherein the content ratio (B) / (C) of the component (B) and the component (C) is 1/100 to 10/1. Skin external preparation. The cosmetic or skin external preparation according to claim 1, wherein the mass ratio (B) / (C) of the component (B) and the component (C) is 1/10 to 5/1. Further contains a pasty oil agent in component (E) 25 ° C., cosmetic or skin external preparation according to claim 1 or 2. Furthermore, component (F) 1 type or 2 or more types chosen from the polyoxyalkylene derivative of glycerol, the polyoxyalkylene derivative of polyglycerol, or the polyoxyalkylene derivative of methyl glucoside are contained , The any one of Claim 1 thru | or 3 Cosmetics or skin external preparations as described in the item . Cosmetic or pH of the skin external agent characterized in that in the neutral range in excess of 6, the cosmetic or skin external preparation according to any one of claims 1 to 4. Molecular weight of the component (D) is characterized in that in the range of 200 to 1000, cosmetic or skin external preparation according to any one of claims 1 to 5. Cosmetic or a viscosity at 25 ° C. the skin external preparation is characterized in that it does not exceed 20,000 mPa · s, cosmetic or skin external preparation according to any one of claims 1 to 6. Maximum particle size of the emulsified droplets of emulsified cosmetics or skin external preparation characterized in that it does not exceed 1 [mu] m, cosmetics or skin external preparation according to any one of claims 1 to 7.