JP6301104B2 - Liquid dosing device - Google Patents

Description

  The present invention relates to a liquid administration device for administering a liquid to a living body.

  As a device for administering a liquid into a living body, for example, Patent Document 1 describes an infusion three-way stopcock in which a filter is fixed to a three-way stopcock used in an infusion line. This infusion three-way cock is provided with a conduit in three directions, a switching portion for switching the flow path is provided at a confluence portion of the three conduits, and a filter is fixed to one of the conduits. The filter is located on the upstream side of the conduit and plays a role of removing foreign substances and bacteria from the chemical and guiding them to the conduit. This infusion three-way stopcock supplies a chemical solution that requires the use of a filter from a conduit to which the filter is fixed, supplies a chemical solution that does not require the use of a filter from the other conduit, and the remaining one conduit. Therefore, it is possible to send the chemical solution to the living body.

Japanese Utility Model Publication No. 05-88554

  In the above-mentioned infusion three-way stopcock, for example, when administration is once stopped, bacteria or the like may enter from a conduit to which the filter is not fixed, and the inside of the three-way stopcock may be contaminated. In this case, when the administration is started again, the filter is located upstream from the switching unit, and therefore, the sterilization effect by the filter cannot be expected for the already contaminated liquid. There is a possibility of intrusion.

  This invention solves the subject mentioned above, and it aims at providing the liquid administration device which can administer only the liquid which is not contaminated with bacteria to a biological body.

A liquid administration device according to the present invention that achieves the above object is a liquid administration device for administering a liquid to a living body, and includes a first port to which a first device serving as a liquid supply source is connected, and bacteria. A sterilization filter that does not pass but allows liquid to pass is provided in the flow path, and a second port to which a second device for administering the liquid to the living body is connected, and an air filter that passes air is provided in the flow path. A first state where the second port is blocked and the first port is communicated with the third port, and the third port is blocked and the first port is communicated with the first port. And a switching unit capable of taking a second state in which the second port communicates and a third state in which the first port is blocked and the second port communicates with the third port. And the first port, the second port, and the third port are Replacement parts Ru formed integrally with the hub body which is arranged rotatably.

  In the liquid administration device configured as described above, the first port and the second port communicate with each other by allowing the switching unit to be in the second state, so that the liquid can be administered. With this state, the communication between the first port and the second port is blocked, and the administration of the liquid can be stopped. Then, by setting the switching unit to the first state, the air in the first port, the third port, and the switching unit is changed to the air before the administration is started by communicating the first port with the air filter. It can be discharged to the outside through a filter. Even if the first port, the third port or the switching unit is contaminated with bacteria or the like, the contaminated liquid must pass through the sterilization filter provided in the second port, Therefore, only a liquid that is not contaminated with bacteria can be administered to the living body.

  If the second device is a tube that is connected in advance to the second port so as not to be detached, the liquid sterilized through the sterilization filter is again contaminated with bacteria in the second device. Can be surely prevented.

  The sterilization filter, if at least one filter surface of the sterilization filter is supported by a sterilization filter support portion that extends linearly along the filter surface and contacts the filter surface, While maintaining the fluidity of the liquid, the pressure resistance can be improved by suppressing the deformation of the sterilization filter.

  If the air filter is configured such that at least one filter surface of the air filter is supported by an air filter support portion that extends linearly along the filter surface and is in contact with the filter surface, air circulation is achieved. The pressure resistance can be improved by suppressing the deformation of the air filter while maintaining the performance.

  If the air filter is provided with a water repellent finish, it is possible to prevent the liquid from passing through while circulating the air, and only the air is effective when the air is excluded from the liquid administration device. The inflow of air into the living body can be effectively suppressed.

  If the liquid administration device is used for convection-enhanced delivery of a substance to a tumor, even if it is convection-enhanced delivery that needs to be administered for a long time, it can satisfactorily suppress the invasion of bacteria into the tumor. it can.

  If the liquid administration device is used for increased convection delivery of substances to the brain, it is possible to satisfactorily suppress the invasion of bacteria into the brain where the invasion of bacteria is undesirable. In particular, the brain is covered with a skull and kept in a sterile state, and the immune mechanism is not developed as compared with other places in the body cavity. Therefore, when treating the brain, it is particularly necessary to prevent the invasion of bacteria even when compared with other places in the body cavity.

It is a top view which shows the liquid administration tool which concerns on embodiment. It is sectional drawing which shows a catheter hub. It is an exploded sectional view showing a catheter hub. It is the top view seen from the AA line of FIG. It is the top view seen from the BB line of FIG. It is the top view seen from the CC line of FIG. It is sectional drawing of the catheter hub in a 1st state. It is sectional drawing of the catheter hub in a 2nd state. It is sectional drawing of the catheter hub in a 3rd state. It is the schematic which shows the state which inserted the liquid administration device which concerns on embodiment into the brain parenchyma.

  Embodiments of the present invention will be described below with reference to the drawings. In addition, the dimension ratio of drawing is exaggerated on account of description, and may differ from an actual ratio.

  In the following description, the proximal side of the catheter is referred to as “proximal end side”, and the inserted side is referred to as “distal end side”.

  The liquid administration device 1 according to the embodiment of the present invention shown in FIGS. 1 to 6 is used for convection-enhanced delivery (CED), which is a drug administration method for malignant glioma. The CED method is a method of injecting a small amount of drug through a stereotaxically placed tube in the brain parenchyma while actively and continuously pressurizing it, thereby maintaining a pressure gradient of the drug and generating convection. This is a local chemotherapy that uses the flow generated thereby to distribute the drug in a wide and high concentration in the tissue gap. Since this local chemotherapy is used for treatment to the brain and may be performed for a long period of about one month, a means for preventing bacteria from entering through a liquid administration device is required. It has been.

  The liquid administration device 1 includes a tube body 10 (second device) that is inserted into the brain parenchyma to deliver a therapeutic substance, and a hub portion 20 that is fixed to the proximal end of the tube body 10. A liquid feeding tube 90 for supplying a liquid containing a therapeutic substance from the outside can be connected to the hub portion 20 of the liquid administration device 1.

  The liquid supply tube 90 has a base end portion 91 into which a tube tip 101 of a syringe 100 (first instrument) that accommodates a therapeutic substance can be inserted, and a male luer lock structure is provided at the distal end portion. A connector 92 is provided. The syringe 100 is attached to a microinjection pump 102 (see FIG. 10) and can deliver a therapeutic substance at a preset injection amount and injection rate.

  The tube body 10 has a lumen 11 formed therein for delivering a liquid containing a therapeutic substance. The lumen 11 is opened at a distal end opening 12 formed on the most distal surface of the tube body 10.

  The outer diameter D of the distal end portion of the tubular body 10 is preferably 0.5 to 3.0 mm, but is not limited thereto. For example, a polyurethane elastomer, a polyamide elastomer, a polyester elastomer, a polyvinyl chloride, a silicone elastomer, or the like can be suitably applied to the tube body 10, but the tube body 10 is not limited thereto.

  The hub portion 20 includes a hub portion main body 30, an air filter 40, a filter cap 50 for fixing the air filter 40 to the hub portion main body 30, a sterilizing filter 60, and a tube body to which the tube body 10 is fixed. The fixing part 70 and the switching part 80 which is rotatably arranged on the hub part main body 30 and switches the flow path are provided.

  The hub part main body 30 is disposed on the cylindrical part 34 having a cylindrical shape, and the first port 31, the second port 32, and the third part arranged on the outer peripheral part of the cylindrical part 34 and projecting radially outward. Port 33.

   The first port 31, the second port 32, and the third port 33 each have a tubular shape and are arranged at equiangular intervals, that is, at an angle of 90 °. In this case, the first port 31 and the second port 32 are arranged at an angle of 180 °, that is, arranged on a straight line. Further, the third port 33 protrudes to the side of the first port 31 and the third port 33, that is, an angle of 90 ° with respect to each of the first port 31 and the third port 33. Are arranged apart from each other. The first port 31, the second port 32, and the third port 33 are disposed at the same height position of the cylindrical portion 34.

  As shown in FIG. 7, the first port 31 is a part to which a connector 92 of a liquid feeding tube 90 is detachably attached and liquid is supplied, and a male luer taper portion 93 where the outer diameter of the connector 92 gradually decreases. A female luer taper portion 312 is formed on the inner surface, and a thread 313 is formed on the outer surface to which a thread groove 95 formed on the inner surface of a lock member 94 rotatably provided on the connector 92 is screwed. The female luer taper portion 312 is formed in a tapered shape whose inner diameter gradually decreases toward the distal end so that the male luer taper portion 93 is in close contact with the liquid. Therefore, by rotating the lock member 94 in a state where the male luer taper portion 93 is fitted to the female luer taper portion 312, the screw thread 313 is engaged with the screw groove 95 and the male luer taper portion 93 is pushed into the female luer taper portion 312. The connector 92 and the first port 31 are connected in a liquid-tight state. A first flow path 311 that communicates with the female luer taper 312 and communicates with the liquid feeding tube 90 is formed inside the first port 31. The first flow path 311 communicates with the lumen 341 of the cylindrical portion 34.

  As shown in FIGS. 2 to 5, the second port 32 has a cylindrical shape and is a part that feeds liquid to the tube body 10, and the sterilization filter 60 is interposed between the tube body fixing portion 70 and the second port 32. While being held, the tube is fixed to the tube fixing portion 70 on the outer side in the radial direction than the circular sterilization filter 60. The second port 32 and the tube fixing portion 70 are fixed in a liquid-tight manner by a method such as ultrasonic fusion or adhesion. A second flow path 321 is formed inside the second port 32. The second flow path 321 communicates with the lumen 341 of the cylindrical portion 34.

  Further, as shown in FIG. 5, the second port 32 has a sterilization filter outer edge support portion 322 that supports the outer edge portion of the circular sterilization filter 60 on the surface in contact with the sterilization filter 60, and the second port 32. A sterilizing filter radial support portion 323 (a sterilizing filter support portion) extending radially along the filter surface of the sterilization filter 60 from the flow path 321 toward the outer edge support portion 322 for the sterilization filter. Yes. For example, three radial support portions 323 for the sterilization filter are formed side by side in the circumferential direction, but the number is not limited.

  Further, as shown in FIGS. 3 and 5, the surface of the second port 32 in contact with the sterilization filter 60 is accommodated on the outer side in the radial direction from the outer edge support portion 322 for sterilization filter. A first step portion 324 is formed in the first step.

  As shown in FIGS. 2 to 4 and 6, the tubular body fixing portion 70 has a tubular shape, and includes a fourth flow path 71 that houses the tubular body 10 and communicates with the lumen 11. The surface is fixed to the second port 32 on the radially outer side of the sterilization filter 60 while supporting the sterilization filter 60. The tube fixing part 70 has a downstream side sterilization filter outer edge support part 72 that supports the outer edge part of the circular sterilization filter 60 on a surface in contact with the sterilization filter 60, and a downstream side sterilization from the fourth channel 71. A downstream sterilization filter radial support portion 73 (a sterilization filter support portion) extending radially along the filter surface of the sterilization filter 60 toward the filter outer edge support portion 72 is provided. For example, three downstream sterilization filter radial support portions 73 are formed side by side at equal intervals in the circumferential direction, but the number is not limited.

  Further, as shown in FIGS. 3 and 6, the surface of the tube fixing part 70 that contacts the sterilization filter 60 is located on the outer side in the radial direction of the downstream sterilization filter outer edge support part 72. A second stepped portion 74 having a shape that matches the one stepped portion 324 is formed. High liquid tightness is realized by fixing the second port 32 and the tube fixing portion 70 while matching the first step portion 324 and the second step portion 74.

  As described above, the sterilization filter 60 is a circular membrane filter that is supported by being sandwiched between the second port 32 and the tube fixing portion 70, and removes the liquid flowing through the second flow path 321. It passes through the fourth channel 71 while sterilizing. The sterilization filter 60 includes a plurality of holes having a size that allows liquid to pass but does not allow bacteria to pass. The diameter of the sterilization filter 60 is, for example, 10 to 20 mm, but is not limited thereto. Since the size of the bacteria is about 0.5 to 1.0 μm, the diameter of the holes formed in the sterilization filter 60 is preferably 0.45 μm or less, and more preferably 0.2 μm or less. preferable. The sterilization filter 60 is formed in a circular shape in the present embodiment, but the shape is not limited. The sterilization filter 60 may not be a membrane filter.

  Examples of the constituent material of the sterilization filter 60 include nonwoven fabrics and papers such as polypropylene, polysulfone, regenerated cellulose, polyamide, polyester, polyethylene, and polytetrafluoroethylene, or those subjected to sealing processing. It is not limited to this.

  As shown in FIGS. 2 to 5, the third port 33 has a cylindrical shape and discharges air to the outside. The third port 33 is circular while holding the air filter 40 between the filter cap 50 and the third port 33. The air filter 40 is fixed to the filter cap 50 on the outer side in the radial direction. The third port 33 and the filter cap 50 are liquid-tightly fixed by a method such as ultrasonic fusion or adhesion. A third flow path 331 is formed inside the third port 33. The third flow path 331 communicates with the lumen 341 of the cylindrical portion 34.

  Further, as shown in FIG. 4, the third port 33 includes an air filter outer edge support portion 332 that supports the outer edge portion of the circular air filter 40 on a surface in contact with the air filter 40, and a third flow path 331. Air filter radial support portions 333 (air filter support portions) extending radially along the filter surface of the air filter 40 toward the air filter outer edge support portion 332. For example, three radial support portions 333 for the air filter are formed side by side at equal intervals in the circumferential direction, but the number is not limited.

  Further, as shown in FIGS. 3 and 4, the third port 33 has a third surface so that the air filter 40 is accommodated on the surface in contact with the air filter 40 on the outer side in the radial direction than the outer edge support portion 332 for air filter. A step portion 334 is formed.

  As shown in FIGS. 2, 3, and 5, the filter cap 50 has an annular shape, and the base end surface supports the air filter 40, while the third port is located radially outside the air filter 40. 33 is fixed. The filter cap 50 includes an air filter upstream support portion 51 that supports an outer edge portion of the circular air filter 40 on a surface in contact with the air filter 40. If the air filter 40 can be fixed to the third port 33, the filter cap 50 may not be provided.

  Further, as shown in FIG. 3, on the surface of the filter cap 50 that contacts the air filter 40, there is a third stepped portion 334 of the third port 33 on the radially outer side of the air filter upstream support portion 51. A fourth stepped portion 52 having a matching shape is formed. The third port 33 and the filter cap 50 are fixed while the third step portion 334 and the fourth step portion 52 are matched, thereby realizing high liquid tightness.

  As described above, the air filter 40 is a circular membrane filter that is sandwiched and supported between the third port 33 and the filter cap 50, and allows air to pass therethrough, as well as the third from the outside. Intrusion of foreign matter into the port 33 is suppressed. It is preferable that the air filter 40 is subjected to water repellent treatment so as to allow air to pass without passing liquid. Although the diameter of the air filter 40 is 10-20 mm, for example, it is not limited to this. The hole diameter of the hole formed in the air filter is preferably 1.0 μm or less, and more preferably 0.45 μm or less. The air filter 40 is formed in a circular shape in the present embodiment, but the shape is not limited. The air filter 40 does not need to be able to completely shut off the liquid. For example, the liquid may flow depending on the pressure. Alternatively, the air filter 40 may be capable of passing liquid without being subjected to water repellent processing. The air filter 40 may not be a membrane filter. Here, the air filter is configured such that the mesh is larger than that of the sterilization filter, and the target particle diameter as a target is larger than that of the sterilization filter. By increasing the mesh size of the air filter 40, it is possible to easily discharge the air mixed inside during priming to the outside.

  Examples of the constituent material of the air filter 40 include non-woven fabric and paper such as polypropylene, polysulfone, regenerated cellulose, polyamide, polyester, polyethylene, polytetrafluoroethylene, or those obtained by applying a sealing process thereto. It is not limited to. For the water-repellent processing, for example, a silicon resin or a fluorine resin can be used.

  When priming the liquid administration device, by providing an air filter, only air can be discharged out of the liquid administration device, and the liquid administration device can be satisfactorily filled with the priming solution. If air remains in the liquid administration device during priming, the air may enter the brain and cause an air embolism, thereby hindering blood supply in the brain. Therefore, it is preferable to provide a means for preventing air intrusion such as an air filter. In addition, if there is no air filter, the liquid administration tool may infiltrate dust or the like larger than the place where the air filter is located to block a part of the sterilization filter, thereby reducing the performance of the sterilization filter.

  As shown in FIGS. 2, 4, and 5, the switching unit 80 includes a cylindrical body part 81, a side plate part 82 provided at one end of the body part 81, and the side plate part 82 orthogonal to the axial direction of the body part 81. And a lever 83 formed in the direction of the movement. The trunk portion 81 has a cylindrical shape, and is rotatably inserted into the lumen 341 of the cylindrical portion 34 with airtightness or liquid tightness. Then, the lever 83 can be grasped with fingers and the switching unit 80 can be rotated. A T-shaped switching flow path 84 that can communicate with the first flow path 311, the second flow path 321, and the third flow path 331 is formed inside the body portion 81.

  The switching unit 80 includes the T-shaped switching flow path 84, so that the lever 83 is rotated to operate the first state shown in FIG. 7, the second state shown in FIG. 8, and the state shown in FIG. The third state shown can be achieved.

  In the first state, as shown in FIG. 7, the switching flow path 84 communicates with the first flow path 311 and the third flow path 331 and does not communicate with the second flow path 321. The part 81 is positioned. As a result, the first port 31 and the third port 33 communicate with each other, and the second port 32 is closed by the outer peripheral surface of the body portion 81 and is blocked from the first port 31 and the second port 32. Is done.

  In the second state, as shown in FIG. 8, the switching channel 84 communicates with the first channel 311 and the second channel 321 and does not communicate with the third channel 331. The part 81 is positioned. As a result, the first port 31 and the second port 32 communicate with each other, and the third port 33 is closed by the outer peripheral surface of the body portion 81 and is cut off from the first port 31 and the second port 32. Is done.

  In the third state, as shown in FIG. 9, the switching channel 84 communicates with the second channel 321 and the third channel 331 and does not communicate with the first channel 311. The part 81 is positioned. As a result, the second port 32 and the third port 33 communicate with each other, and the first port 31 is closed by the outer peripheral surface of the body portion 81 and is blocked from the second port 32 and the third port 33. Is done.

  For example, polyolefin such as polypropylene, polycarbonate, or the like can be used as the constituent material of the hub body 30, the tube fixing portion 70, the filter cap 50, and the switching portion 80, but is not particularly limited.

  Examples of therapeutic substances contained in the liquid include anticancer agents, more specifically, alkylating agents such as nimustine, ranimustine, and temozolomide, platinum preparations such as cisplatin, oxaliplatin, and dahaplatin, sulfazine, methotrexate, fluorouracil, fructocin, azathioprine. Antimetabolite such as pentostatin, topoisomerase inhibitor such as irinotecan, doxorubicin, levofloxacin, microtubule depolymerization inhibitor such as paclitaxel, dotaxel, antitumor antibiotics such as doxorubicin, epirubicin, bleomycin, imatinib, gefitinib, sunitinib Molecular target drugs such as cetuximab, trastuzumab, and the like, but are not limited thereto.

  Next, the usage method (action) of the liquid administration device 1 according to this embodiment will be described.

  First, by turning the lever 83, the second state shown in FIG. 8 is obtained. The first port 31 and the second port 32 are communicated with each other by the switching channel 84, and the third port 33 is connected. The first port 31 and the second port 32 are disconnected from each other. Thereafter, the male luer taper portion 93 of the liquid feeding tube 90 connected to the syringe 100 attached to the microinjection pump 102 is fitted into the female luer taper portion 312 of the first port 31, and the lock member 94 is rotated. Thereby, the male luer taper portion 93 is pushed into the female luer taper portion 312 and the connector 92 and the first port 31 are connected in a liquid-tight state. As a result, the liquid stored in the syringe 100 can be supplied to the lumen 11 of the tubular body 10 via the first port 31 and the second port 32.

  Next, the microinjection pump 102 is operated to supply the liquid from the syringe 100, and the liquid administration device 1 is primed. The liquid supplied from the syringe 100 passes through the connector 92 and passes through the first flow path 311, the switching flow path 84, the second flow path 321, the sterilization filter 60, the fourth flow path 71, and the lumen 11. The air is discharged from the distal end opening 12 of the tube body 10, and the air inside is discharged.

  Next, the liquid administration device 1 is grasped, and the tubular body 10 is inserted into the brain parenchyma until the tip of the tubular body 10 reaches the brain tumor in the brain parenchyma or in the vicinity of the brain tumor as shown in FIG. .

  Next, the liquid is supplied from the syringe 100, and the liquid is released from the distal end opening 12 of the tube body 10 at a predetermined injection volume and injection speed, and is directly and continuously administered and delivered to the brain tumor. At this time, by reducing the diameter of the tube body 10 and setting the liquid injection speed to a very low speed of 0.5 to 10 μl / min, the liquid administered from the distal end opening 12 of the tube body 10 is It is possible to suppress backflow in the proximal direction along the outer peripheral surface of the tenth. The fluid delivered from the tubular body 10 into the brain parenchyma is effectively guided and diffused between the brain cortex while maintaining the pressure gradient. Since the liquid to be administered passes through the sterilization filter 60, bacteria and foreign substances are surely removed, and the safety is high.

  When temporarily stopping the administration of the liquid, the microinjection pump 102 is operated to stop the supply of the liquid by the syringe 100, the lever 83 is gripped and the switching unit 80 is rotated, as shown in FIG. In the third state. In the third state, the first port 31 is blocked from the second port 32 and the third port 33, so that liquid cannot be fed from the first port 31 to the tube body 10. . Since the second port 32 communicating with the brain parenchyma communicates with the third port 33 provided with the air filter 40, the third port 33 functions as a pressure regulating valve, and is connected to the brain parenchyma. The burden can be reduced. Since the second port 32 communicates with the brain parenchyma via the sterilization filter 60, bacteria and foreign substances do not enter the brain parenchyma, and the safety of the living body can be maintained. The connector 92 connected to the syringe 100 may be removed from the first port 31, but it is not necessary to remove it. When the connector 92 is removed, the first port 31 is preferably covered with a cap or the like. If it is not necessary to cause the third port 33 to function as a pressure regulating valve when the administration of the liquid is stopped, the second state is set as the first state as shown in FIG. The port 32 may be blocked from the first port 31 and the third port 33.

  Thereafter, when the administration of the liquid is resumed, if the connector 92 connected to the syringe 100 is disconnected from the first port 31, the connector 92 is connected to the first port 31. Next, the lever 83 is gripped and the switching unit 80 is rotated to enter the first state as shown in FIG. In the first state, the second port 32 is blocked from the first port 31 and the third port 33, and the first port 31 and the third port 33 communicate with each other. When supply of the liquid by the syringe 100 is started in this state, the air in the first flow path 311, the third flow path 331 and the switching flow path 84 can be discharged to the outside via the air filter 40, Intrusion of air into the living body can be suppressed.

  After the air in the first flow path 311, the third flow path 331, and the switching flow path 84 is excluded, the lever 83 is gripped and the switching unit 80 is rotated, as shown in FIG. State. In the second state, the first port 31 and the second port 32 are communicated with each other by the switching channel 84, and the third port 33 is blocked from the first port 31 and the second port 32. It becomes a state. Thereafter, the microinfusion pump 102 can be adjusted to release the liquid at a predetermined infusion volume and rate and resume administration of the liquid to the brain tumor. At this time, even when the administration is stopped, the first port 31 or the third port 33, the switching unit 80, etc. are contaminated with bacteria or the like before the liquid is administered into the brain parenchyma. Since there is no contamination source that passes through the bacteria filter 60 and downstream of the bacteria removal filter 60, bacteria and foreign substances are reliably removed by the bacteria removal filter 60, and high safety can be maintained.

  Thereafter, the administration is repeatedly stopped and restarted as necessary. After the administration is completed, the supply of the liquid by the syringe 100 is stopped, the liquid administration device 1 is removed from the living body, and the treatment is completed.

  As described above, the liquid administration device 1 according to the present embodiment is a device for administering a liquid to a living body, and is a first device to which a syringe 100 (first device) serving as a liquid supply source is connected. A port 31 and a sterilization filter 60 that does not allow bacteria to pass but allows liquid to pass therethrough are provided in the flow path, and the second port 32 to which the tubular body 10 (second instrument) for administering the liquid to the living body is connected. A first state in which an air filter 40 for passing air is provided in the flow path, and a first state in which the second port 32 is blocked and the first port 31 and the third port 33 are communicated with each other, The second state in which the third port 33 is blocked and the first port 31 and the second port 32 communicate with each other, and the first port 31 is blocked and the second port 32 and the third port 33 are blocked. A switching unit 80 capable of taking a third state for communicating with To. For this reason, by setting the switching unit 80 to the second state, the first port 31 and the second port 32 communicate with each other so that liquid can be administered, and the first state or the third state is set. Thus, the communication between the first port 31 and the second port 32 is blocked, and the administration of the liquid can be stopped. Then, by setting the switching unit 80 to the first state, the first port 31 and the third port 33 are communicated with the air filter 40 before the administration is started (resumed). And the air in the switching part 80 can be easily discharged | emitted via the air filter 40. FIG. Even if the first port 31, the third port 33, or the switching unit 80 is contaminated, the contaminated liquid always passes through the sterilization filter 60 provided in the second port 32, and then the tubular body 10. Therefore, only a clear liquid that is not contaminated with bacteria can be administered to the living body.

  Therefore, when long-time administration is required or when repeated administration is repeated intermittently, bacteria enter the first port 31 or the third port 33 and the inside of the hub 20 is contaminated with bacteria. However, only a clear liquid can be administered into the living body. In particular, in the CED method, administration may be performed with an interval of several days to several tens of days. Therefore, in consideration of the patient's QOL, the liquid delivery tube 90 should be removed from the liquid administration device 1 during non-administration. Therefore, there is a possibility that bacteria may propagate in the hub 20 when not administered. Even in such a case, according to the liquid administration device 1 according to the present embodiment, the sterilization filter 60 is provided in the second port 32, so that only a clear liquid can be administered into the living body.

  In addition, since the tube body 10 (second instrument) is the tube body 10 that is connected in advance to the second port 32 so as not to be detached, the liquid sterilized through the sterilization filter 60 is removed from the tube body 10. It can be surely prevented from being contaminated by bacteria again. Even if the tube body 10 is connected to the second port 32 in a non-detachable manner in advance, the air in the first port 31 and the third port 33 can be discharged through the air filter 40, so that the liquid Even when the administration is repeated, the entry of air into the body can be suppressed.

  Further, the sterilization filter 60 has a radial support for the sterilization filter in which at least one (both in the present embodiment) filter surface of the sterilization filter 60 extends linearly along the filter surface and is in contact with the filter surface. Since it is supported by the part 323 and the downstream sterilization filter radial support part 73 (the sterilization filter support part), the pressure resistance is improved by suppressing the deformation of the sterilization filter 60 while maintaining the fluidity of the liquid. Can be made.

  Further, the air filter 40 is for an air filter in which a filter surface of at least one of the air filters 40 (in the present embodiment, the hub portion main body 30 side) extends linearly along the filter surface and contacts the filter surface. Since it is supported by the radial support portion 333 (air filter support portion), it is possible to improve the pressure resistance by suppressing the deformation of the air filter 40 while maintaining air circulation.

  In addition, since the air filter 40 is subjected to water repellent processing, it is possible to prevent the liquid (water) from passing through while circulating the air, and only the air when the air is excluded from the liquid administration device 1. Can be effectively eliminated, and the inflow of air into the living body can be effectively suppressed.

  In addition, since the liquid administration device 1 is used for convection-enhanced delivery of substances to the tumor, it is possible to satisfactorily suppress the invasion of bacteria into the tumor even for convection-enhanced delivery that requires long-time administration. .

  In addition, since the liquid administration device 1 is used for increased convection delivery of substances to the brain, it is possible to satisfactorily suppress the invasion of bacteria into the brain where the invasion of bacteria is undesirable. In particular, the brain is covered with a skull and kept in a sterile state, and the immune mechanism is not developed as compared with other places in the body cavity. Therefore, when treating the brain, it is particularly necessary to prevent the invasion of bacteria even when compared with other places in the body cavity.

  Note that the present invention is not limited to the above-described embodiments, and various modifications can be made by those skilled in the art within the technical idea of the present invention. For example, the liquid administration device 1 according to the present embodiment administers a liquid containing a therapeutic substance to a brain tumor, but the administration site is not particularly limited as long as it is in vivo. Moreover, although the liquid administration device 1 which concerns on this embodiment is used for convection increase delivery, the method to administer may not be convection increase delivery.

  Moreover, although the liquid administration tool 1 which concerns on this embodiment is provided with three ports, you may provide four or more ports. In addition, the liquid administration device 1 according to the present embodiment has a structure in which the body 81 provided with the switching channel 84 is rotated in order to switch the channel, but if the channel can be switched, the structure is It is not limited.

  In the present embodiment, the second device for administering the liquid to the living body is the tubular body 10 that is connected to the second port 32 so as not to be detached in advance, but the second device is the second device. The structure may be removable from the port.

  In the present embodiment, the first instrument serving as the liquid supply source is the syringe 100, but is not particularly limited as long as the liquid can be supplied, and may be a tube pump or the like, for example.

1 liquid administration device,
10 tube (second instrument),
20 Hub part,
31 first port,
32 second port,
323 Radial support part for sterilization filter (support part for sterilization filter),
33 Third port,
333 Radial support for air filter (support for air filter),
40 Air filter,
60 sanitizing filter,
73 downstream sterilization filter radial support part (sterilization filter support part),
80 switching section,
100 Syringe (first instrument).

Claims (7)

A liquid administration device for administering a liquid to a living body,
A first port to which a first instrument serving as a liquid source is connected;
A sterilization filter that does not pass bacteria but allows liquid to pass therethrough, and a second port to which a second device for administering the liquid to the living body is connected;
A third port in which an air filter for passing air is provided in the flow path;
A first state in which the second port is blocked and the first port and the third port are communicated; and the third port is blocked and the first port and the second port are communicated. It possesses a second state, and the first said block the port of the second port and the switching unit that can take the third state for communicating the third port to, and
The first port, the second port, and the third port are liquid administration devices that are integrally formed on a hub part body in which the switching part is rotatably arranged .   The liquid administration device according to claim 1, wherein the second device is a tube that is connected to the second port in advance so as not to be detached.   The sterilization filter is supported by a sterilization filter support portion in which at least one filter surface of the sterilization filter extends linearly along the filter surface and contacts the filter surface. A liquid administration device according to 1.   4. The air filter according to claim 1, wherein at least one filter surface of the air filter is supported by an air filter support portion that extends linearly along the filter surface and contacts the filter surface. 2. A liquid administration device according to item 1.   The liquid administration device according to any one of claims 1 to 4, wherein the air filter is subjected to water repellent processing.   The liquid administration device according to any one of claims 1 to 5, which is used for increased convection delivery of a substance to a tumor.   The liquid administration device according to any one of claims 1 to 6, which is used for increased convection delivery of a substance to the brain.

Images