JP6214529B2 - Sebum-absorbing patch and method for producing the same - Google Patents

Description

  The present invention relates to a sebum-absorbing patch that can be applied for a long time even in places where the location of the application is not conspicuous and the amount of sebum is secreted.

  The patch material generally has a layer structure including a support layer made of a plastic film, a woven fabric, a nonwoven fabric, a knitted fabric, paper, and the like, and an adhesive layer provided on at least one side of the support layer. Furthermore, a separator layer may be disposed to protect the surface of the pressure-sensitive adhesive layer, or, for example, when the support layer is extremely thin, the support layer may have a carrier layer. Many.

  In many cases, the patch is required to be inconspicuous in the pasted state. In particular, when the patch is applied to a part such as a face where the skin is exposed in daily life, it is preferable that the applied part is not conspicuous, so that the thickness of the patch is preferably thin. In addition, a sticking material having a small thickness may be preferably used because it adheres along the unevenness of the skin surface and does not feel uncomfortable at the time of sticking or during sticking.

  On the other hand, the patch is required to have an appropriate adhesive strength. If the adhesive strength is too weak, the patch may be easily peeled off from the skin surface, or may not adhere to the skin surface with fine irregularities such as skin grooves. If the adhesive strength is too strong, rash may occur or peeling after use becomes difficult. When the thicknesses of the support layer, the pressure-sensitive adhesive layer, and the patch are made thin, it is difficult to obtain an appropriate adhesive force.

  Also, in places that secrete a lot of sebum, especially in places where acne is likely to occur, such as the face, shoulders, chest, back, neck, buttocks, etc. The adhesive strength of the patch may be reduced. For example, when a patch applied to a part that secretes a large amount of sebum, such as a T zone, absorbs sebum secreted from the skin, the cohesive force of the adhesive is reduced, and the patch may be easily peeled off. In view of this, it has been considered necessary to sufficiently increase the thickness of the pressure-sensitive adhesive layer in order to prevent the sebum from being removed even if a large amount of sebum is absorbed.

  On the other hand, it is necessary to keep the part with acne as clean as possible. If a foundation or the like is applied directly to the skin after washing the face, redness of the skin where acne is present may be promoted or suppuration may occur. Therefore, there has been a demand for an adhesive material that has no fear of skin redness or the like and is less noticeable even when applied to acne.

  For example, Patent Document 1 discloses an adhesive, fragrance, and fatty acid ester on one side of a support layer as a nasal patch that exhibits good adhesion over a long period of time, has no skin irritation, and has no pain at the time of peeling. A nasal patch provided with a pressure-sensitive adhesive layer formed from a pressure-sensitive adhesive composition containing the above is disclosed. Patent Document 2 discloses a pressure-sensitive adhesive article in which a pressure-sensitive adhesive layer is arranged in a pattern so that the area of a region where the pressure-sensitive adhesive layer does not exist is 15 to 75% on an absorbent substrate. Patent Document 3 discloses a patch-type device containing an anti-acne (ie, acne) preparation containing at least two active ingredients. Further, in Patent Document 4, in a thin patch applied to a human face or the like, both the support layer and the pressure-sensitive adhesive layer are in close contact with each other along the surface having fine irregularities on the skin. There is disclosed a thin adhesive material in which the difference in surface state between the adhesive and the adhesive is inconspicuous.

  However, these adhesives are still inadequate in terms of the effect that they adhere closely along the unevenness of the skin surface and the sticking places are not noticeable, and the sticking is maintained over a long period of time in places where the secretion of sebum is high. It wasn't.

JP 2006-8593 A JP 2007-215578 A Special Table 2000-513347 (corresponding to International Publication No. 97/48387) International Publication No. 2009/041122 (corresponding to US Patent Application Publication No. 2010/0217171)

  The object of the present invention is to adhere closely along the unevenness of the skin surface, there is no sense of incongruity at the time of application and during application, the application site is not noticeable, and the application is maintained for a long time even at a site where there is a lot of sebum secretion. In particular, an object of the present invention is to provide a sebum-absorbing patch used for acne.

  As a result of earnest research on solving the above-mentioned problems, the present inventors are a patch comprising a carrier layer, a support layer, a pressure-sensitive adhesive layer, and a separator layer laminated in this order. It has been found that the above-mentioned problems can be solved by using the pressure-sensitive adhesive layer as a specific material and controlling the thickness thereof.

  The components of human sebum are composed of various substances. Examples include fatty acids, triacylglycerols (triglycerides; hereinafter sometimes referred to as “TG”), diacylglycerols (diglycerides), monoacylglycerols (monoglycerides), wax esters, squalene, cholesterol, cholesterol esters, and the like. Among these, triglyceride accounts for about half of human sebum when it is large, and it has been found that it affects the adhesiveness of the patch to human skin as compared with other components. As a result of further research, the present inventor, in an artificial sebum absorption test using triglyceride, adhered to the skin surface unevenness by adhering to a predetermined range of the retention strength against glass after triglyceride absorption. The present inventors have found that it is possible to provide a sebum-absorbing patch that does not stand out and can be applied to a site where a large amount of sebum is secreted for a long period of time, thereby completing the present invention.

That is, according to the present invention, a patch comprising a carrier layer, a support layer, a pressure-sensitive adhesive layer, and a separator layer laminated in this order, the following (a) to (e):
(A) the support layer is formed from an elastomeric film;
(B) The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is
b-1) (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms, 50 to 99% by mass,
b-2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms, 0-12% by mass, and b-3) other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester The acrylic copolymer consisting of 1 to 50% by mass of the body [where b-1), b-2) and b-3) are 100% by mass in total. A non-aqueous acrylic pressure-sensitive adhesive containing
(C) The thickness of the support layer is in the range of 1 to 10 μm, the thickness of the pressure-sensitive adhesive layer is in the range of 1 to 15 μm, and the total thickness of the support layer and the pressure-sensitive adhesive layer is in the range of 2 to 20 μm;
(D) the carrier layer is larger than the support layer; and
(E) In an artificial sebum absorption test using triglyceride, the retention force against glass (load 200 g) after triglyceride absorption is in the range of 0.1 to 1 mm / 12 × 20 mm · 1 hour;
A sebum-absorbing adhesive material characterized by the above is provided.

Moreover, according to this invention, the sebum absorptive patch of the following (1)-(14) is provided as an embodiment.
(1) (b) The acrylic copolymer contained in the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer contains 60 to 70% by mass of isononyl acrylate, 1 to 5% by mass of a carboxyl group-containing vinyl monomer, and an alkoxy group. Acrylic copolymer comprising 10 to 40% by mass of vinyl monomer [however, the total is 100% by mass. ] The above-mentioned sebum-absorbing patch.
(2) Further, in the (f) human skin sebum absorption test, the above-mentioned sebum-absorbing patch wherein the value of the cebumeter after peeling of the patch is 12 or less.
(3) Further, in the artificial sebum absorption test using (g) triglyceride, the above-mentioned sebum-absorbing patch having an adhesive strength to bakelite after absorption of triglyceride of 0.2 N / 15 mm or more.
(4) The sebum-absorbing patch, wherein the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer contains 0.05 to 3 parts by mass of a crosslinking agent with respect to 100 parts by mass of the acrylic copolymer.
(5) The above-mentioned sebum-absorbing patch, wherein the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer does not contain a plasticizer that is liquid at room temperature.
(6) The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer contains at least one drug selected from the group consisting of an anti-inflammatory agent, an exfoliating agent, an antibacterial agent, a sebum secretion inhibitor, a rough skin improving agent, and an antioxidant. The said sebum absorptive patch.
(7) The above-mentioned sebum absorbing patch, wherein the adhesive forming the adhesive layer contains a sebum absorbent.
(8) The sebum-absorbing patch as described above, wherein the elastomer film forming the support layer is a polyether type polyurethane elastomer film or a polyester type polyurethane elastomer film.
(9) The sebum-absorbing patch, wherein the surface of the support layer opposite to the pressure-sensitive adhesive layer is embossed.
(10) The sebum-absorbing patch, wherein the moisture permeability of the patch is 1,000 g / m ² · 24 hours or more.
(11) The above-mentioned sebum-absorbing patch, wherein the 10% tensile strength of the patch is in the range of 0.01 to 1.2 N / 10 mm.
(12) The sebum-absorbing patch material used for acne.
(13) The sebum-absorbing patch for the T zone or U zone.
(14) The above-mentioned sebum-absorbing patch that is used for sticking after face washing.

  Furthermore, according to the present invention, the method includes a step of forming a support layer on the upper surface of the carrier layer by a solution casting method, and a step of forming an adhesive layer by applying an adhesive to the upper surface of the separator layer. A method for producing the above-described sebum-absorbing patch is provided.

According to the present invention, there is provided a patch comprising a carrier layer, a support layer, a pressure-sensitive adhesive layer, and a separator layer laminated in this order, and the following (a) to (e):
(A) the support layer is formed from an elastomeric film;
(B) The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is
b-1) (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms, 50 to 99% by mass,
b-2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms, 0-12% by mass, and b-3) other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester The acrylic copolymer consisting of 1 to 50% by mass of the body [where b-1), b-2) and b-3) are 100% by mass in total. A non-aqueous acrylic pressure-sensitive adhesive containing
(C) The thickness of the support layer is in the range of 1 to 10 μm, the thickness of the pressure-sensitive adhesive layer is in the range of 1 to 15 μm, and the total thickness of the support layer and the pressure-sensitive adhesive layer is in the range of 2 to 20 μm;
(D) the carrier layer is larger than the support layer; and
(E) In an artificial sebum absorption test using triglyceride, the retention force against glass (load 200 g) after triglyceride absorption is in the range of 0.1 to 1 mm / 12 × 20 mm · 1 hour;
Because it is a sebum-absorbing patch characterized by the fact that it adheres along the unevenness of the skin surface, there is no sense of incongruity during or during application, the application site is not noticeable, and there is a lot of sebum secretion In addition, there is an effect that it is possible to provide a sebum-absorbing patch that can be applied for a long time.

  Moreover, according to the present invention, the method includes a step of forming a support layer on the upper surface of the carrier layer by a solution casting method, and a step of forming an adhesive layer by applying an adhesive to the upper surface of the separator layer. By being the manufacturing method of the sebum absorptive patch characterized by the above, there exists an effect that the manufacturing method which can manufacture the said sebum absorptive patch efficiently can be provided.

  The sebum-absorbing patch of the present invention is a patch comprising a carrier layer, a support layer, an adhesive layer and a separator layer laminated in this order.

1. Support Layer In the sebum-absorbing patch of the present invention, the support layer is formed from an elastomer film, and the thickness of the support layer is in the range of 1 to 10 μm.

In general, the support layer of the patch is a flexible material that can adhere to the skin and can follow the movement of the skin, and suppresses the occurrence of skin irritation after prolonged application. Materials that can be used. Examples of the material for these support layers include polyethylene, polypropylene, polyethylene terephthalate (hereinafter sometimes referred to as “PET”), polybutylene terephthalate, polyethylene naphthalate, polystyrene, nylon, cotton, acetate rayon, rayon, Rayon / polyethylene terephthalate composite, polyacrylonitrile, polyvinyl alcohol, acrylic polyurethane, polyester polyurethane, polyether polyurethane, styrene-isoprene-styrene copolymer, styrene-butadiene-styrene copolymer, styrene-ethylene-propylene- Examples thereof include a single layer or a laminate of a film containing styrene copolymer, styrene-butadiene rubber, ethylene-vinyl acetate copolymer, cellophane and the like as components. In order to suppress the occurrence of skin irritation and the like, the support layer has a moisture permeability of the support layer (measured under the B condition (temperature 40 ° C., relative humidity 90%) defined in JIS Z0208). 000 g / m ² · 24 hours or more, particularly 2,000 g / m ² · 24 hours or more is preferably used. Furthermore, a plastic film with excellent transparency is often preferably used in order to prevent the adhesive material from becoming noticeable during application, that is, to easily show through the color tone of the skin under application.

[Elastomer film]
The sebum-absorbing patch of the present invention includes a support layer formed from an elastomer film as a support layer that satisfies these conditions such as moisture permeability and transparency. Examples of the elastomer forming the elastomer film include polyurethane elastomers, 1,2-polybutadiene thermoplastic elastomers, polystyrene thermoplastic elastomers, polyolefin thermoplastic elastomers, and mixtures of two or more thereof. it can. Among these elastomers, it has excellent film-formability on thin films, excellent film stretchability, and it is easy to control the 10% tensile strength in the longitudinal and lateral directions of the patch within a desired range. In view of the above, a polyurethane elastomer is preferable.

  A polyurethane elastomer is an elastomer having a urethane group in the molecule, and is produced by a polyaddition reaction between a polyol component and an isocyanate component. As the polyol component, a polyol compound having two or more OH groups is used, and in many cases, a long-chain diol is used. In addition, as the polyol component, a short-chain diol that works as a chain extender may be used in combination. Moreover, you may use monomolecular polyols, such as a trimethylol propane, glycerol, and sorbitol, as a crosslinking agent. On the other hand, as the isocyanate component, a polyisocyanate compound having two or more NCO groups is used, and in many cases, a diisocyanate is used. The technology for producing polyurethane elastomers per se is well known in the art.

  Examples of polyurethane elastomers include thermoplastic polyurethane elastomers and thermosetting polyurethane elastomers (amine curable polyurethane elastomers and OH curable polyurethane elastomers), and are not particularly limited. Thermoplastic elastomers include fully thermoplastic polyurethane elastomers with few NCO groups, and incomplete thermoplastic polyurethane elastomers that retain a considerable amount of NCO groups and cause partial intermolecular crosslinking during molding. Any of them can be used in the invention. The thermosetting polyurethane elastomer includes a one-component curable type and a two-component curable type, and both can be used, but the one-component curable type is preferable from the viewpoint of easy film production.

  Polyurethane elastomers can be classified according to the type of polyol component because the type of polyol component constituting the soft segment greatly affects its properties. That is, polyurethane elastomers are (1) polyester type polyurethane elastomer (caprolactone type polyurethane elastomer) synthesized by polyaddition reaction of polylactone ester polyol obtained by ring-opening polymerization of caprolactone and diisocyanate, and (2) adipic acid and glycol. Polyester methylene elastomer synthesized by polyaddition reaction of adipic acid ester polyol and diisocyanate (adipic acid ester type polyurethane elastomer), and (3) polytetramethylene glycol or polypropylene glycol obtained by ring-opening polymerization of tetrahydrofuran Polyether type polyols synthesized by polyaddition reaction of polyether polyols such as polyalkylene glycols with diisocyanates. There is a urethane elastomer. In these polyurethane elastomers, a polyol having 3 or more OH groups and / or a polyisocyanate having 3 or more NCO groups may be used.

  In the present invention, a polyether type polyurethane elastomer or a polyester type polyurethane elastomer is preferably used. That is, as the elastomer film forming the support layer, a polyether type polyurethane elastomer film or a polyester type polyurethane elastomer film is preferable.

  Examples of the polyether-type polyurethane elastomer preferably used include those described above. Similarly, the polyester type polyurethane elastomer preferably used includes the caprolactone type polyurethane elastomer and the adipic acid ester type polyurethane elastomer. As the polyurethane elastomer suitable for the present invention, as a commercial product, a rack skin (registered trademark) US2268 (polyether type) manufactured by Seiko Kasei Co., Ltd .; a rack skin U-1223, U-1285, and U-2860 (polyester type) ) ;, but is not limited thereto. These polyurethane elastomers can be used alone or in combination of two or more.

  The glass transition temperature (Tg) of the elastomer forming the elastomer film is not particularly limited. For example, some highly elastic polyurethane elastomers have a glass transition temperature exceeding 50 ° C. The glass transition temperature of the elastomer is preferably in the range of −70 ° C. to 20 ° C. from the viewpoints of elasticity, flexibility, 10% tensile strength, etc. of the elastomer film. The upper limit value of the glass transition temperature is preferably 20 ° C, more preferably 10 ° C, and particularly preferably 0 ° C. In many cases, the lower limit of the glass transition temperature is −60 ° C. or −55 ° C. The glass transition temperature of the elastomer is a value measured using a differential scanning calorimeter according to a conventional method.

[Thickness of support layer]
The support layer provided in the sebum-absorbing patch of the present invention is an elastomer film having a thickness in the range of 1 to 10 μm. The thickness of the support layer is preferably in the range of 2 to 9 μm, more preferably 3 to 7 μm. The thickness of the support layer can be reduced to a range of 2 to 6 [mu] m from the viewpoint of the conspicuousness of the sticking material being stuck and the relaxation of the uncomfortable feeling. When the thickness of the support layer is less than 1 μm, the strength of the support layer becomes insufficient, and the support layer is cut when the patch is applied to the skin or peeled off from the skin. In some cases, it may be difficult to produce the support layer. If the thickness of the support layer is too large, the thickness of the patch increases, and as a result, the patch is less likely to adhere along the skin surface with fine irregularities such as skin grooves, the sticking state is easily noticeable, and the sense of discomfort is large. Prone. The thickness of the support layer is measured using a dial thickness gauge. The method for measuring the thickness of the other layers of the patch is the same.

[10% tensile strength of support layer]
It is preferable that the support layer has a small difference (anisotropy) depending on the direction of physical properties in that it has less uncomfortable feeling during application (resistance of the adhesive felt when the skin stretches). When the solution casting method described later is adopted as the film forming method, the physical properties such as 10% tensile strength are in the longitudinal direction [refers to the machine traveling direction (MD) when the patch is produced. ] And the horizontal direction (refers to a direction (TD) orthogonal to the machine direction). ], A thin elastomer film that is substantially the same can be obtained. Even in other film forming methods, the 10% tensile strength of the elastomer film is not greatly different between the vertical direction and the horizontal direction. The 10% tensile strength in the machine direction and the transverse direction of the support layer (elastomer film) is preferably in the range of 0.01 to 1.2 N / 10 mm, more preferably 0.03 to 1 N / 10 mm. Preferably it is the range of 0.05-0.6N / 10mm. The 10% tensile strength of the support layer is 10% tensile strength (unit: N / 10 mm) measured according to JIS Z0237 (average value of n = 3).

  As will be described later, the 10% tensile strength of the patch is preferably 0.01 to 1.2 N / 10 mm, more preferably 0.03 to 1 N / 10 mm, and still more preferably 0.05 to 0.6 N / 10 mm. It is a range. There is no significant difference between the vertical direction and the horizontal direction. On the other hand, since the contribution of the adhesive layer included in the patch to the tensile strength of the patch is small, the 10% tensile strength of the support layer is substantially the same as the 10% tensile strength of the patch (the carrier layer and The separator layer is removed when the patch is applied to the skin.) Therefore, the 10% tensile strength of the support layer can be represented by the 10% tensile strength in the longitudinal direction of the patch, which will be described later.

  If the 10% tensile strength of the support layer (elastomer film) is too small, the thickness is generally too small, so that the film-forming property and handleability are deteriorated. If the 10% tensile strength of the support layer is too large, the support layer and the adhesive material will have high rigidity, and the elasticity and flexibility will be insufficient. Therefore, the adhesive material will follow fine irregularities on the skin surface such as skin grooves. It becomes difficult to adhere and the sticking state becomes conspicuous. In addition, the patch having an elastomer film having a 10% tensile strength that is too large as a support layer is more uncomfortable at the time of peeling to the skin surface.

〔Additive〕
If desired, the elastomer film forming the support layer may contain various additives such as colorants such as pigments and dyes, stabilizers, ultraviolet absorbers, and lubricants. The content of these additives may be selected in an optimum range depending on the kind of the additive, but is usually 0.001 to 30 parts by mass, preferably 0. 0 to 100 parts by mass with respect to 100 parts by mass of the resin material constituting the elastomer film. In many cases, the range is from 01 to 25 parts by mass, more preferably from 0.1 to 20 parts by mass.

[Embossing]
When the patch is applied to the human skin surface, in order to improve the touch, slipperiness, appearance, etc. of the patch, the back surface of the support layer constituting the patch (the adhesive layer side of the support layer) Means a surface located on the opposite side.), It may be preferable to form minute irregularities. That is, it can be set as the sticking material by which the surface on the opposite side to the adhesive layer side of a support body layer is embossed. By embossing, the dynamic friction coefficient of the support layer surface can be reduced to less than 1.0. In addition, if minute irregularities are formed on the surface of the carrier layer by embossing and a support layer is formed on the minute irregular surface, the surface (back surface) of the support layer formed from an elastomer film Minute irregularities can be transferred.

  The support layer may be subjected to surface treatment such as sandblasting or corona treatment on one side or both sides for the purpose of improving anchoring properties with the adhesive. Moreover, in order to make it easy to take out the patch from the packaging material, irregularities can be provided on one side or both sides of the support layer by a method other than sandblasting.

2. Pressure-sensitive adhesive layer The sebum-absorbing patch of the present invention has a pressure-sensitive adhesive that forms a pressure-sensitive adhesive layer.
b-1) (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms, 50 to 99% by mass,
b-2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms, 0-12% by mass, and b-3) other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester The acrylic copolymer consisting of 1 to 50% by mass of the body [where b-1), b-2) and b-3) are 100% by mass in total. ], And the thickness of the pressure-sensitive adhesive layer is in the range of 1 to 15 μm.

(1) Adhesive In general, the adhesive layer of the patch is formed using an adhesive that exhibits pressure-sensitive adhesive properties at room temperature, and an adhesive that is weak in skin irritation is preferably used. Examples of adhesives include acrylic adhesives, natural rubber adhesives, synthetic rubber adhesives, silicone adhesives, vinyl ester adhesives, vinyl ether adhesives, urethane adhesives, and the like. Among them, a medical adhesive grade is preferably used.

[Acrylic adhesive]
The sebum-absorbing patch of the present invention is less likely to cause skin irritation, adheres along the unevenness of the skin surface, and is not noticeable. Since it is easy to control the adhesive properties, a non-aqueous acrylic adhesive is used as the adhesive for forming the adhesive layer.

[Acrylic copolymer]
That is, in the sebum-absorbing patch of the present invention, the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is b-1) 50-99% by mass of (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms, b -2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms, 0-12 mass%, and b-3) other vinyl monomers copolymerizable with the (meth) acrylic acid alkyl ester The acrylic copolymer consisting of 1 to 50% by mass (however, the sum of b-1), b-2) and b-3) is 100% by mass. ] A non-aqueous acrylic pressure-sensitive adhesive containing

[B-1) (Meth) acrylic acid alkyl ester having C8-12 alkyl group]
b-1) (Meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms includes n-octyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, isooctyl (meth) acrylate, ( Examples thereof include isononyl (meth) acrylate, n-decyl (meth) acrylate, isodecyl (meth) acrylate, lauryl (meth) acrylate, and the like. Among these (meth) acrylic acid alkyl esters, acrylic acid alkyl esters having an alkyl group having 8 to 9 carbon atoms such as 2-ethylhexyl acrylate and isononyl acrylate are particularly preferable. These alkyl (meth) acrylates can be used alone or in combination of two or more.

  b-1) The content of the (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms is 50 to 99% by mass, preferably 55 to 98.5% by mass, more preferably in the copolymer. It is 60-98 mass%. The acrylic acid alkyl ester having an alkyl group having 8 to 9 carbon atoms, which is particularly preferably used, can be used at a content of 65 to 98% by mass. The sebum-absorbing patch of the present invention is an acrylic copolymer in which the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer contains a predetermined amount of b-1) (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms. As a result, the adhesive easily absorbs the sebum component secreted from the skin, the patch can be made difficult to peel off, and a sebum-absorbing patch can be obtained.

[B-2) (Meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms]
b-2) (Meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms includes methyl (meth) acrylate, ethyl (meth) acrylate, n-butyl (meth) acrylate, (meth) Examples thereof include isobutyl acrylate, t-butyl (meth) acrylate, and n-hexyl (meth) acrylate, and these can be used alone or in combination of two or more. Preferably, it is n-butyl acrylate.

  b-2) The content of the (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms is 0 to 12% by mass, preferably 0 to 11% by mass, more preferably 0 in the acrylic copolymer. ˜10.5% by mass. b-2) The (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms may be 0% by mass. Therefore, in the sebum-absorbing patch of the present invention, b-2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms is an acrylic copolymer that is an adhesive that forms an adhesive layer. It is not an essential ingredient. In the acrylic copolymer, b-2) when the content of the (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms exceeds 12% by mass in the acrylic copolymer, it was secreted from the skin. The adhesive may not easily absorb sebum components, and the patch may be easily peeled off.

[B-3) Other vinyl monomers copolymerizable with the (meth) acrylic acid alkyl ester]
b-3) The other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester is b-1) an alkyl (meth) acrylate having an alkyl group having 8 to 12 carbon atoms. An ester and a monomer having a vinyl group that does not belong to any of b-2) a (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms, and at least b -1) A vinyl monomer copolymerizable with a (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms.

  b-3) As another vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester, b-1) copolymerized with a (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms. There is no particular limitation as long as the vinyl monomer is a vinyl monomer other than the (meth) acrylic acid alkyl ester of b-1) or b-2), but acrylic acid, methacrylic acid Carboxyl group-containing vinyl monomers such as maleic acid, maleic anhydride, itaconic acid, and derivatives thereof (acid anhydride group-containing vinyl monomers); vinyl esters such as vinyl acetate; 2-methoxyethyl acrylate, methacrylic acid (Meth) acrylic acid alkoxyalkyl esters such as 2-methoxyethyl acid, 2-ethoxyethyl acrylate, 2-butoxyethyl acrylate, etc. (Meth) acrylamide (amide group-containing vinyl monomer) such as acrylamide, methacrylamide, N-methylolacrylamide and derivatives thereof; epoxy group-containing vinyl such as glycidyl acrylate and glycidyl methacrylate Monomers; cyano group-containing vinyl monomers (unsaturated nitriles) such as acrylonitrile and methacrylonitrile; vinyl aromatic compounds such as styrene; and pentyl acrylate, pentyl methacrylate, tridecyl acrylate (Meth) acrylic acid alkyl esters having an alkyl group having 7 or 13 carbon atoms, such as tridecyl methacrylate and tetradecyl acrylate, can also be used. Preferably, an alkoxy group-containing vinyl monomer; a vinyl monomer having a functional group such as a carboxyl group, an acid anhydride group, an amide group, or an epoxy group; a vinyl ester; more preferably an alkoxy group-containing vinyl monomer Body; carboxyl group-containing vinyl monomer; or vinyl ester. Particularly preferred are 2-methoxyethyl acrylate, acrylic acid or vinyl acetate, and these may be used in combination.

  b-3) The content of the other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester is 1 to 50% by mass in the acrylic copolymer, preferably 1.5 to 45% by mass, More preferably, it is 2-40 mass%. In the sebum-absorbing patch of the present invention, the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is an acrylic copolymer containing a predetermined amount of b-3) other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester. The total amount of the polymers (b-1), b-2) and b-3) is 100% by mass. ], The various properties of the pressure-sensitive adhesive layer can be improved, and a sebum-absorbing patch with excellent handleability can be obtained.

  For example, b-3) An alkoxy group-containing vinyl monomer that is particularly preferably used as the other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester imparts hydrophilicity to the pressure-sensitive adhesive layer. The pressure-sensitive adhesive layer can be moisture permeable or hygroscopic. Examples of the alkoxy group-containing vinyl monomer include acrylic acid alkoxyalkyl esters having an alkoxy group having 1 to 4 carbon atoms, such as 2-methoxyethyl acrylate, 2-ethoxyethyl acrylate, and 2-butoxyethyl acrylate. Each can be used alone or in combination of two or more. An alkoxy group-containing vinyl monomer in the case where the acrylic copolymer contains an alkoxy group-containing vinyl monomer as another vinyl monomer copolymerizable with b-3) the (meth) acrylic acid alkyl ester. The content of is preferably 5 to 45% by mass, more preferably 10 to 40% by mass in the acrylic copolymer.

  Similarly, b-3) a carboxyl group-containing vinyl monomer preferably used as another vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester crosslinks the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer. While being able to ensure the reaction point at the time of processing, the cohesion force of the acrylic copolymer obtained can be improved. Examples of the carboxyl group-containing vinyl monomer include acrylic acid and methacrylic acid, which can be used alone or in combination of two or more. Carboxyl group-containing vinyl monomer when the acrylic copolymer contains a carboxyl group-containing vinyl monomer as the other vinyl monomer copolymerizable with b-3) the (meth) acrylic acid alkyl ester The content of is preferably 1 to 10% by mass, more preferably 1.5 to 7% by mass, and further preferably 2 to 5% by mass in the acrylic copolymer.

  Furthermore, b-3) Vinyl ester preferably used as the other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester can impart cohesion to the pressure-sensitive adhesive layer. Examples of the vinyl ester include vinyl acetate, vinyl propionate, vinyl pivalate and the like, and each can be used alone or in combination of two or more. When the acrylic copolymer contains vinyl ester as the other vinyl monomer copolymerizable with b-3) the (meth) acrylic acid alkyl ester, the content of the vinyl ester in the acrylic copolymer Is preferably 3 to 20% by mass, more preferably 5 to 15% by mass.

  In the sebum-absorbing patch of the present invention, (b) the acrylic copolymer contained in the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is particularly preferably 60 to 70% by mass of isononyl acrylate and a carboxyl group-containing vinyl monomer. Acrylic copolymer consisting of 1 to 5% by mass of a monomer and 10 to 40% by mass of an alkoxy group-containing vinyl monomer [the total is 100% by mass. ]. The most preferred acrylic copolymer is an acrylic copolymer comprising 60 to 70% by mass of isononyl acrylate, 1 to 5% by mass of acrylic acid, and 10 to 40% by mass of 2-methoxyethyl acrylate. %. ].

[Production of acrylic copolymer]
The acrylic copolymer contained in the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer provided in the sebum-absorbing patch of the present invention can be produced by radical polymerization. Known polymerization methods for acrylic copolymers include solution polymerization methods, emulsion polymerization methods, bulk polymerization methods, etc., but the pressure-sensitive adhesive layer provided in the sebum-absorbing patch of the present invention provides good adhesive properties. The solution polymerization method is preferable because it is easy. Examples of the polymerization initiator for obtaining the acrylic copolymer include organic peroxides such as benzoyl peroxide and lauroyl peroxide; azo initiators such as azobisisobutyronitrile; and the like. Specifically, 0.1 to 3 parts by mass of radicals per 100 parts by mass of all the monomers consisting of the above b-1), b-2) and b-3) forming the acrylic copolymer. A polymerization initiator is added, and the mixture is stirred for 30 minutes to 30 hours at a temperature of about 40 to 90 ° C. in a nitrogen stream for copolymerization. In the solution polymerization method, ethyl acetate, acetone, toluene, or a mixture thereof is generally used as a solvent.

  The weight average molecular weight of the acrylic copolymer is usually in the range of 100,000 to 1,500,000, preferably 300,000 to 1,000,000, more preferably 450,000 to 650,000. By setting the weight average molecular weight of the acrylic copolymer within the above range, the cohesiveness, adhesive strength, mixing workability with other components, affinity with other components, and the like can be balanced. The weight average molecular weight of an acrylic copolymer is the value calculated | required as a standard polystyrene conversion value by the gel permeation chromatography (GPC) method.

[Non-aqueous acrylic adhesive]
The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer provided in the sebum-absorbing patch of the present invention is a non-aqueous acrylic pressure-sensitive adhesive containing the acrylic copolymer. In the present invention, “non-aqueous” means forming a pressure-sensitive adhesive layer when a patch comprising a carrier layer, a support layer, a pressure-sensitive adhesive layer, and a separator layer in this order is obtained through a manufacturing process. This means that the pressure-sensitive adhesive is substantially free of water. Therefore, the “non-aqueous acrylic pressure-sensitive adhesive” in the present invention means that the acrylic pressure-sensitive adhesive that forms the pressure-sensitive adhesive layer substantially contains water when a patch is obtained through the manufacturing process. As long as the adhesive layer of the adhesive patch is exposed to the air and naturally absorbs moisture, the acrylic adhesive that forms the adhesive layer does not absorb water. It does not mean that it does not contain. The sebum-absorbing patch of the present invention can be applied by using a non-aqueous acrylic pressure-sensitive adhesive that is a solution or dispersion using a non-aqueous solvent as a solvent or dispersion medium as a pressure-sensitive adhesive for forming the pressure-sensitive adhesive layer. The sebum absorbability of the material can be improved. As the non-aqueous solvent contained in the non-aqueous acrylic pressure-sensitive adhesive, a solvent used for producing an acrylic copolymer by a solution polymerization method can be used.

〔Additive〕
In addition to the acrylic copolymer formed from b-1), b-2) and b-3), the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer of the sebum-absorbing patch of the present invention is necessary. Depending on the case, various additives can be contained. Additives such as cross-linking agents, drugs, fillers, antioxidants (antioxidants, preservatives), colorants, fragrances, tackifiers, plasticizers, and the like that form a pressure-sensitive adhesive layer included in a patch Additives commonly used in US Pat. For example, a tackifier can be blended in order to adjust the adhesive properties of the adhesive. Examples of the tackifier include tackifier resins such as terpene, terpene phenol, coumarone indene, styrene, rosin, xylene, phenol, and petroleum.

[Crosslinking agent]
A crosslinking treatment is not essential for the acrylic copolymer contained in the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer provided in the sebum-absorbing patch of the present invention. Therefore, the pressure-sensitive adhesive in the present invention does not necessarily contain a crosslinking agent together with the acrylic copolymer. However, if desired, the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer may contain a crosslinking agent as desired. As a crosslinking agent, polyfunctional isocyanate compounds [tolylene diisocyanate (TDI), 4,4′-diphenylmethane diisocyanate (MDI), hexamethylene diisocyanate, xylylene diisocyanate, metaxylylene diisocyanate, 1,5-naphthalene diisocyanate, hydrogenation Diphenylmethane diisocyanate, hydrogenated tolylene diisocyanate, hydrogenated xylylene diisocyanate, isophorone diisocyanate, etc.] and polyfunctional epoxy compounds. Examples of commercially available products include Coronate (registered trademark) HL and coronate manufactured by Nippon Polyurethane Industry L, Coronate EH, Mitsubishi Gas Chemical Co., Ltd. TETRAD (registered trademark) X can be obtained. When the acrylic pressure-sensitive adhesive is formed using a crosslinking agent, the content of the crosslinking agent is preferably 0.05 to 3 parts by mass, more preferably 100 parts by mass with respect to the acrylic copolymer. Is 0.1 to 2 parts by mass, particularly preferably 0.2 to 1 part by mass, but depending on the appropriate cohesiveness desired for the adhesive forming the adhesive layer, the type of adhesive composition and crosslinking agent In consideration of the above, the content of the crosslinking agent is adjusted. The cross-linking agent may be used alone or in combination of two or more types, and at the same time, it is not necessary to add two or more types, and is added before or during the application of the pressure-sensitive adhesive for forming the pressure-sensitive adhesive layer. The method of doing is mentioned.

[Plasticizer]
The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer in the present invention does not usually need to contain a plasticizer contained in the pressure-sensitive adhesive in the patch. Examples of the plasticizer include polyhydric alcohols (glycerin, sorbitol, propylene glycol, 1,3-butylene glycol, 1,3-tetramethylene glycol, polyethylene glycol, etc.); phenols (thymol, safrole, isosafrole, Eugenol, isoeugenol, etc.); higher alcohols (benzyl alcohol, oleyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, octyldodecanol, etc.); ester surfactants (sorbitan sesquioleate, polyoxyethylene hydrogenated castor oil) Fatty acid esters (isopropyl myristate, octyldodecyl myristate, oleyl oleate, diethyl phthalate, dibutyl phthalate, etc.) ; Organic acids (lactic acid, citric acid, tartaric acid, maleic acid, malic acid); plasticizers are known in liquid form at room temperature such. These plasticizers contained in the adhesive in the patch may irritate the skin, but were usually used to impart flexibility to the adhesive forming the adhesive layer . However, since the acrylic pressure-sensitive adhesive which is the pressure-sensitive adhesive in the present invention has sufficient flexibility by containing the acrylic copolymer, the pressure-sensitive adhesive provided in the sebum-absorbing patch of the present invention. The pressure-sensitive adhesive forming the layer does not need to include a plasticizer that is liquid at room temperature, but rather does not include a plasticizer that is liquid at room temperature. In the present invention, “does not include a plasticizer that is liquid at room temperature” means that the content does not affect the adhesive properties by including a plasticizer that is liquid at room temperature, In some cases, the content is usually 2 parts by mass or less, preferably 0.5 parts by mass with respect to 100 parts by mass of the acrylic pressure-sensitive adhesive.

[Drugs, etc.]
The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer in the present invention can contain various drugs usually contained in the pressure-sensitive adhesive in the patch. Examples of such drugs include pyridoxine dicaprylate, dipotassium glycyrrhizinate, pyridoxine dipalmitate, glycyrrhizic acid, diphenhydramine hydrochloride, buckwheat extract, glycyrrhizyl stearate, lysozyme chloride, aminocaproic acid, litchi extract, yocuinine, merirot extract, button extract, toki extract Anti-inflammatory agents such as citrus root extract, root extract, genus cucumber extract, alloin extract, and arnica extract; antibacterial agents such as shikonin, hinokitiol, cedrol, benzalkonium chloride, benzethonium chloride, photosensitizer 201, and adipic acid Sebum secretion inhibitors such as estradiol, vitamin B2, vitamin B6, royal jelly extract, riboflavin; porous nylon powder and porous cellulose powder Oil-absorbing porous powder such as kaolin, talc, clay, zinc oxide, etc .; exfoliating agent such as salicylic acid, sulfur, bentonite, cyclodextrin; dibutylhydroxytoluene, tocopherol acetate, ascorbic acid, benzoic acids, Antioxidants (preservatives) such as parabens, benzalkonium chloride, and benzethonium chloride; Arnica montana extract, licorice extract, retinol, dipotassium glycyrrhizinate, peony extract, sage leaf extract, loquat leaf extract, rosemary extract, etc. Skin roughening agents; antioxidants such as vitamins and butylhydroxytoluene; various analgesics and anti-inflammatory agents; antihistamines; corticosteroids; moisturizers; vitamins;

  In the sebum-absorbing patch of the present invention, if necessary, the adhesive forming the adhesive layer is composed of an anti-inflammatory agent, an exfoliating agent, an antibacterial agent, a sebum secretion inhibitor, a rough skin improving agent, and an antioxidant. It is preferable to contain at least one drug selected from the group consisting of In particular, when the sebum-absorbing patch of the present invention is used for acne, it is particularly preferable to contain an anti-inflammatory agent. In the sebum-absorbing patch of the present invention, it is preferable that the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer contains a sebum absorbent. Particularly preferred drugs include pyridoxine dicaprylate, dipotassium glycyrrhizinate, pyridoxine dipalmitate, glycyrrhizic acid, diphenhydramine hydrochloride, anti-inflammatory agents such as agate extract, and exfoliating agents such as bentonite and cyclodextrin; dibutylhydroxytoluene, tocopherol acetate, ascorbine Antioxidants (preservatives) such as acids; or sebum absorbents such as kaolin, talc, clay, and zinc oxide.

  Furthermore, the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer in the present invention may contain a filler such as calcium carbonate, magnesium carbonate, silicate, zinc oxide, titanium oxide, magnesium sulfate, and calcium sulfate as necessary. it can.

  The effective content of the drug or filler described above varies depending on the type of drug or filler, but is preferably 0.001 to 10% by mass, particularly 0.01 to 2%, based on the total mass of the pressure-sensitive adhesive layer. It is preferable to contain by mass.

[Thickness of adhesive layer]
The thickness of the pressure-sensitive adhesive layer provided in the sebum-absorbing patch of the present invention is in the range of 1 to 15 μm, preferably 3 to 13 μm, more preferably 5 to 12 μm. The pressure-sensitive adhesive layer provided in the sebum-absorbing patch of the present invention is an acrylic copolymer in which the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is a combination of the specific amounts of the above b-1), b-2) and b-3). By being a non-aqueous acrylic pressure-sensitive adhesive containing a polymer, even if the thickness of the pressure-sensitive adhesive layer is thinner than the thickness of the pressure-sensitive adhesive layer provided in a normal patch, it exhibits moderate tackiness and a lot of sebum Excellent adhesion can also be obtained at the location of secretion.

[Thickness of support layer and pressure-sensitive adhesive layer]
The sebum-absorbing patch of the present invention has a total thickness of the support layer and the pressure-sensitive adhesive layer in the range of 2 to 20 μm, preferably 5 to 19 μm, and more preferably 8 to 17 μm. If the total thickness of the support layer and the pressure-sensitive adhesive layer is too small, the strength of the patch is insufficient, and it may break when the patch is applied to the skin or when the patch is peeled from the skin. In addition, the adhesiveness to the skin may be insufficient, and adhesion to a portion that secretes a large amount of sebum may be insufficient. On the other hand, if the total thickness of the support layer and the pressure-sensitive adhesive layer is too large, the adhesive material is less likely to adhere along fine irregularities on the skin surface such as skin grooves, the attached state is easily noticeable, and the sense of discomfort tends to increase. At the same time, when the patch is peeled from the skin, the skin may be damaged or pain may be felt.

3. Carrier layer The sebum-absorbing patch of the present invention is a patch comprising a carrier layer, a support layer, an adhesive layer and a separator layer laminated in this order. The sebum-absorbing patch of the present invention comprises a carrier layer adjacent to the support layer, whereby the handleability of the patch and the adhesiveness to the skin can be improved, and the sebum-absorbing property of the present invention. In the method for producing a patch, the support layer can be easily formed. In other words, when the patch is applied to the skin, the support layer may wrinkle or the patch may be bent and the adhesive layers may adhere to each other, but the patch is adjacent to the support layer. By providing the carrier layer, the shape retaining property of the patch is improved, so that such a problem can be prevented. Further, as described above, the support layer provided in the sebum-absorbing patch of the present invention has a thickness in the range of 1 to 10 μm and is extremely thin, so that the support layer is formed alone. Although there are technical difficulties, as described later, the step of forming a support layer on the surface (upper surface) of the carrier layer by the solution casting method, and the carrier layer and the support layer are extrusion laminated. By employing a process or the like, the support layer can be easily formed.

  The thickness of the carrier layer can be appropriately set and is not particularly limited, but is usually 20 μm or more, preferably 40 μm or more, and the upper limit is about 500 μm. The carrier layer can be formed using a film made of various thermoplastic resins, for example, polyurethane, polyethylene, polypropylene, ionomer, polyamide, polyvinyl chloride, polyvinylidene chloride, ethylene vinyl acetate copolymer, thermoplastic. A film made of polyester, polytetrafluoroethylene, or the like can be used. Moreover, the laminated body of these films and paper can be used.

  The carrier layer can be easily peeled off from the support layer during use, that is, when the patch is applied to the skin. Therefore, the carrier layer and the support layer are formed so as to be peelable by thermocompression bonding or adhesion. In order to adjust the peeling force between the carrier layer and the support layer, an adhesive, a liquid plasticizer, a release agent, etc. may be applied to the surface of the carrier layer facing the support layer. The surface treatment may be performed.

[Size of carrier layer]
The sebum-absorbing patch of the present invention has a carrier layer larger than the support layer. That is, the carrier layer provided in the sebum-absorbing patch of the present invention is provided so that it can be easily peeled off from the support layer when the patch, specifically, the support layer and the adhesive layer are applied to the skin. In the present invention, the carrier layer is larger than the support layer. When the carrier layer is larger than the support layer, it becomes easy to peel off the adhesive layer of the adhesive material from the separator layer described later by using the carrier layer as a gripping part of the adhesive material, and the finger is adhesive. The adhesive layer of the patch can be applied to the skin without touching the agent. Here, “the carrier layer is larger than the support layer” means a state where the entire surface of the carrier layer does not cover the support layer, in other words, a portion where the carrier layer does not cover the support layer. It means having. For example, in addition to the case where the area of the carrier layer is larger than the area of the support layer (in this case, a part of the carrier layer covers the support layer), the carrier layer is formed in a pattern such as a lattice. In the case where the end portion of the support layer protrudes from the support layer, the carrier layer may be provided so as to cover the edge of the support layer so as to protrude from the support layer. The carrier layer may be provided so as to cover the support layer in a state of being divided into a plurality of sheets or partially overlapping. In addition, you may arrange | position the sheet | seat provided with the chamfering and cut | interruption for improving a handleability further on the carrier layer upper surface (surface on the opposite side of a support body layer).

4). Separator layer The sebum-absorbing patch of the present invention is a patch comprising a carrier layer, a support layer, an adhesive layer, and a separator layer laminated in this order. That is, the sebum-absorbing adhesive material of the present invention has a separator layer adjacent to the adhesive layer in order to protect the adhesive layer until the adhesive material, specifically, the adhesive layer is applied to the skin. Prepare.

  The separator layer in the present invention is not particularly limited, and is generally used as a release paper, a release film, a release paper, a release film, a release liner or the like in the technical field of a patch (adhesive tape). Can be used. Specifically, for example, a polyethylene terephthalate film whose surface is treated with silicone, a laminate of polyethylene whose surface is treated with silicone and paper, and the like can be given. The separator layer may protect the pressure-sensitive adhesive layer as two or more sheets having the same or different thickness. Further, the separator layer may be provided with a cut line in order to improve handleability (that is, peelability from the pressure-sensitive adhesive layer), be formed in a larger area than the adhesive material, and be provided with a grip portion at the peripheral portion. Also good. In addition, the separator layer may be provided with unevenness by sandblasting or the like on the surface facing the pressure-sensitive adhesive layer of the separator layer or on the surface opposite to the pressure-sensitive adhesive layer for the purpose of improving the handleability and the printability. Good. Furthermore, the separator layer may be provided as a single large sheet, and a plurality of combinations of the pressure-sensitive adhesive layer, the support layer, and the carrier layer may be arranged on the separator layer. Will be shared.

  The thickness of the separator layer can be appropriately set and is not particularly limited, but is usually 20 μm or more, preferably 40 μm or more, and the upper limit is about 500 μm.

[Peeling force of separator layer and peeling force of carrier layer]
The force required to peel the separator layer from the adhesive layer of the patch (separator peel force) is set smaller than the force to peel the carrier layer from the support layer of the patch (carrier layer peel force). ing. By setting in this way, after the separator layer is peeled off from the adhesive layer of the patch, the carrier layer remains integrally on the support layer, so that the patch is applied until the patch is applied to the skin. Since the material has a certain degree of rigidity, it is easy to handle.

5. Sebum-absorbing patch The sebum-absorbing patch of the present invention is a patch comprising a carrier layer, a support layer, an adhesive layer and a separator layer laminated in this order, and further an artificial sebum using triglycerides. In the absorption test, the sebum-absorbing patch is characterized in that the holding power against glass (load 200 g) after absorption of triglyceride is in the range of 0.1 to 1 mm / 12 × 20 mm · 1 hour. Also preferably, it is a sebum-absorbing patch with a cebumeter value of 12 or less after peeling of the patch in a human skin sebum absorption test. Further, preferably, in the artificial sebum absorption test using triglyceride, the sebum-absorbing patch has an adhesive strength to bakelite after absorption of triglyceride of 0.2 N / 15 mm or more.

[Pattern shape]
The sebum-absorbing patch of the present invention is a patch comprising a carrier layer, a support layer, a pressure-sensitive adhesive layer, and a separator layer, which are laminated in this order, and further, provided that the above-mentioned various characteristics are provided. The shape is not particularly limited, and a sebum-absorbing patch having a predetermined shape, a roll-shaped sebum-absorbing patch, or a sebum-absorbing patch enclosed in a bag may be used. The sebum-absorbing patch having a predetermined shape is preferably substantially rectangular or circular. In particular, the sebum absorbent patch material used in acne applications, since it is desirable to affix a patch around a place where there is acne, area 1 to 5 cm ^2, preferably about 1 to 3 cm ² circular or oval A sebum-absorbing patch having a shape is preferable. In addition, in a sebum-absorbing patch having a predetermined shape having corners around the periphery, R may be appropriately provided at the surrounding corners.

[Retention force against glass after triglyceride absorption (load 200 g)]
The sebum-absorbing patch of the present invention is an artificial sebum absorption test using triglycerides, which is referred to as “glass holding power after triglyceride absorption (load 200 g)” (hereinafter referred to as “glass holding power after triglyceride absorption (load 200 g)”). May be 0.1 to 1 mm / 12 × 20 mm · 1 hour. The sebum-absorbing patch of the present invention absorbs sebum and has a cohesive failure when the triglyceride-absorbing power (glass load) is in the range of 0.1 to 1 mm / 12 × 20 mm · 1 hour. Adhesion can be maintained without. As a result, the sebum-absorbing patch of the present invention adheres along the unevenness of the skin surface, so that the location where the sebum-absorbing patch is applied is inconspicuous, and it is maintained for a long time even in areas where sebum secretion is high. It is a sebum-absorbing patch. That is, as described above, human sebum components are composed of various substances, but triglycerides occupy about half of human sebum at most, and in comparison with other components, It affects the adhesiveness of the material to human skin. Therefore, the artificial sebum absorption test using triglyceride was carried out, and the adhesive strength to glass after applying triglyceride to the adhesive material, particularly the adhesive layer (load 200 g) was 0.1-1 mm / 12 × 20 mm · If it is the range for 1 hour, it can be said that it is an excellent sebum-absorbing patch. The sebum-absorbing patch of the present invention has a glass holding power after triglyceride absorption, preferably 0.15 to 0.8 mm / 12 × 20 mm · 1 hour, more preferably 0.2 to 0.7 mm / 12 ×. It is in the range of 20 mm · 1 hour. Further, depending on the application, those having a glass holding power after triglyceride absorption of 0.2 to 1 mm / 12 × 20 mm · 1 hour can be preferably used.

  The glass holding power (load 200 g) after absorption of triglyceride is measured by the following method. That is, in an atmosphere at a temperature of 23 ° C. and a relative humidity of 50%, triglyceride (Nikko Chemicals, NIKKOL (registered trademark) Triester F810) is dropped on a glass plate with a capillary and stretched uniformly. The test piece cut out from the adhesive material was brought into contact with the adhesive material and the glass plate within a range of the width of the test piece (TD direction, the same applies hereinafter) 12 mm × length (MD direction, the same applies hereinafter) 20 mm. The pressure-sensitive adhesive layer and the triglyceride are brought into contact with each other and attached to the glass plate, and then reciprocally pressed at a speed of 300 mm / min with a 2 kg rubber roll (applying about 4 mg of triglyceride per test piece, Adjust the dripping amount and extension range.) After standing for 12 hours, the holding power to glass of the patch (adhesive layer) is measured. The glass holding force is measured in accordance with JIS Z0237 by hanging the test piece of the patch so that it hangs vertically, applying a 200 g load, and measuring the deviation length (mm) of the test piece after 1 hour. The retention strength against glass of the test piece was taken as the retention strength against glass (load 200 g) after absorption of triglyceride of the sebum-absorbing patch (average value of n = 3. The unit display is “mm / 12 × 20 mm · 1”. Time ”.) In addition, when the test piece of the patch is dropped during the measurement of the glass holding force, the fact is recorded.

[Retention force against glass after triglyceride absorption (load: 500 g)]
The sebum-absorbing patch of the present invention has a glass holding force (load 500 g) after absorption of triglyceride of 1 mm / 12 × 20 mm · 1 hour or more from the viewpoint of improving the usability of the patch. preferable. The holding power against glass (load 500 g) after absorption of triglyceride was measured by applying a load of 500 g instead of a load of 200 g in the above-described measuring method of holding power against glass (load 200 g) after absorption of triglyceride. The holding power of the patch to glass (average value of n = 3). When the triglyceride absorption force against glass (load 500 g) is less than 1 mm / 12 × 20 mm · 1 hour, the cohesiveness of the adhesive is too high, and you may feel uncomfortable while applying the sebum-absorbing patch. When the sebum-absorbing patch is peeled from the skin, there may be a feeling of resistance or pain, or a feeling of use may not be good. The sebum-absorbing patch of the present invention has a glass holding power (load 500 g) after absorption of triglyceride, more preferably 1.1 mm / 12 × 20 mm · 1 hour or more, and still more preferably 1.5 mm / 12 × 20 mm · It may be 1 hour or longer, and the test piece of the patch may fall during the test of glass holding power (load 500 g) after absorption of triglyceride.

[Value of Cebumeter after peeling of adhesive material]
The sebum-absorbing patch of the present invention further has a cebumeter value after peeling of the patch (hereinafter, also referred to as “cebmeter value after peeling of patch”) of 12 in the human skin sebum absorption test. The following is preferable. If the value of the cebumeter after peeling of the patch is 12 or less, it can be said that no sebum remains on the skin after peeling of the patch, so that it is possible to obtain a more excellent sebum-absorbing patch. .

  The method of measuring the value of the cebumeter after peeling of the patch is based on the human skin sebum absorption test carried out by the following method. Is measured and evaluated. That is, a test piece cut out to a size of 15 mm width × 50 mm length from the patch is pasted on a forehead from which water after washing of 7 adult male and female subjects was wiped off. After 12 hours, the test piece was peeled off from the applied part, and a sebum (Sebumeter (registered trademark) SM815, manufactured by Curage & Khazaka) was applied to the skin of the forehead where the adhesive material was peeled off. The amount is measured, the average value of the seven persons is obtained, and set as the value of the cebumeter after the patch is peeled off. If the value of the cebumeter after peeling of the patch is 12 or less, it can be said that sebum is sufficiently absorbed by the patch (adhesive), and therefore, the sebum absorbability of the patch is evaluated as excellent. can do. The value of the cebumeter after peeling off the patch of the patch is more preferably 10 or less, still more preferably 7 or less. If there is a subject who has lost the patch before 12 hours have passed, or if there is a subject whose sebum amount cannot be measured by the Cebumeter due to cohesive failure of the adhesive, that fact is recorded.

[Adhesion to Bakelite after absorption of triglycerides]
The sebum-absorbing patch of the present invention further has an adhesive strength against bakelite after triglyceride absorption (hereinafter, referred to as “adhesive strength against bakelite after triglyceride absorption”) in an artificial sebum absorption test using triglyceride. It is preferable that it is 0.2 N / 15 mm or more. If the adhesive strength to bakelite after absorption of triglyceride is 0.2 N / 15 mm or more, it will not easily peel off due to external force such as skin movement when applied to the skin. It becomes. The sebum-absorbing patch of the present invention has a bakelite adhesive force after triglyceride absorption of preferably 0.22 N / 15 mm or more, more preferably 0.24 N / 15 mm or more. If the sebum-absorbing adhesive material has an excessively low bakelite adhesive strength after triglyceride absorption, the adhesive material may fall off during application. The upper limit of the adhesive strength against bakelite after triglyceride absorption of the sebum-absorbing patch of the present invention is not particularly limited, but when the adhesive strength against bakelite after triglyceride absorption is too large, the adhesive is peeled off from the skin surface after being applied. Since there is a possibility of feeling resistance and pain, it is usually 1 N / 15 mm, and in many cases 0.9 N / 15 mm.

  The adhesive strength against bakelite after absorption of triglyceride is measured by the following method. That is, in an atmosphere having a temperature of 23 ° C. and a relative humidity of 50%, a triglyceride (Nikko Chemicals Corporation, NIKKOL Triester F810) is placed on a bakelite plate (phenol resin plate, Sumitomo Bakelite Co., Ltd., PL-1102) on a capillary. A test piece cut to 15 mm width x 70 mm length from the patch was pasted on the bakelite plate so that the adhesive layer was in contact with the triglyceride, and a 2 kg rubber roll 1 reciprocating at a speed of 300 mm / min (adjust the amount of triglyceride to be dropped and the range to be stretched so that about 10 mg of triglyceride is applied per test piece). After standing for 12 hours, the adhesive strength of the patch (adhesive layer) to bakelite is measured. The adhesive strength to bakelite is measured in accordance with JIS Z0237 under the conditions of a peeling angle of 90 degrees and a peeling speed of 300 mm / min, and the adhesive strength to the bakelite (unit: N / 15 mm) of the test piece is calculated ( average value of n = 3).

[Evaluation of conspicuousness of sticking points]
The seven subjects who conduct the above-mentioned human skin sebum absorption test were asked to evaluate the conspicuousness of the sticking point of the patch, and the evaluation of the conspicuousness of the sticking point of the patch was performed according to the following criteria. If it is AA or A evaluation, it can be said that it is a sebum absorptive patch with a sticking location hardly conspicuous.
AA: 6 to 7 people are hardly noticeable.
A: 4-5 people are not easily noticeable.
B: 2 to 3 people are not easily noticeable.
C: One or zero name is not easily noticeable.

[Adhesive residue]
The condition of the adhesive residue at the pasting site of the patch after peeling off the patch of the seven subjects performing the human skin sebum absorption test was visually observed, and 0 (no glue residue), 1 (no glue residue) (Slightly recognized) Evaluated in 4 stages, 2 (remaining glue residue is more than 1), 3 (remaining adhesive residue), rounded off the average value of 7 persons, and applied the patch according to the following criteria It is assumed that the remaining adhesive is evaluated. If the evaluation of the adhesive residue is AA or A, it can be said that the feeling of use of the patch is excellent.
AA: The average value of 4 stages is 0.
A: The average value of 4 stages is 1.
B: The average value of 4 stages is 2.
C: The average value of 4 stages is 3.

[Peeling resistance]
7 subjects who perform the above human skin sebum absorption test were asked to evaluate the peel resistance of the patch after 12 hours of applying the patch, and 0 (no peel resistance), 1 (slight peel resistance), Evaluate in 4 stages of 2 (Peeling resistance is greater than 1) and 3 (High peeling resistance), round off the average value of 7 persons, and evaluate the peeling resistance of the patch in accordance with the following criteria . If evaluation of peeling resistance is AA or A, it can be said that there is no sense of incongruity at the time of peeling of a patch.
AA: The average value of 4 stages is 0.
A: The average value of 4 stages is 1.
B: The average value of 4 stages is 2.
C: The average value of 4 stages is 3.

[Pain when peeling]
Ask the seven subjects who perform the above-mentioned human skin sebum absorption test whether there is any pain when the patch is peeled off after applying the patch for 12 hours, 0 (do not feel pain), 1 (feel a little pain) 2 (feeling pain more strongly than 1), 3 (feeling pain more intense), and rounding the average value of 7 people. Based on the following criteria, Assume evaluation. If evaluation of the pain at the time of peeling is AA or A, it can be said that there is no sense of incongruity at the time of peeling of the patch.
AA: The average value of 4 stages is 0.
A: The average value of 4 stages is 1.
B: The average value of 4 stages is 2.
C: The average value of 4 stages is 3.

[12 hours adhesion]
7 subjects who conduct the above-mentioned human skin sebum absorption test were asked to evaluate the state of application of the patch during 12 hours, and the evaluation of adhesiveness of the patch for 12 hours was performed in light of the following criteria. If evaluation of adhesiveness for 12 hours is AA or A, it can be said that there is no sense of incongruity during sticking of the patch.
AA: 6 to 7 people have good adhesion.
A: 4 to 5 people have good adhesion.
B: 2 to 3 people have good adhesion.
C: 1 name or 0 name has good adhesion.

[Adhesive strength of adhesive material (adhesive strength to BA-SUS plate)]
The sebum-absorbing patch of the present invention further exhibits an adhesive strength in the range of 0.1 to 1 N / 15 mm in a 90-degree peel test of a BA-SUS plate (Bright annealed stainless steel) according to JIS Z0237. Is preferable, more preferably 0.2 to 0.95 N / 15 mm, and still more preferably 0.4 to 0.9 N / 15 mm. The sebum-absorbing adhesive material of the present invention has an adhesive strength against BA-SUS plate within the above range, so that when it is applied to the skin, it is not easily peeled off by an external force such as skin movement, and is applied at the same time. There is no feeling of resistance or pain when peeling from the skin surface after applying the material. If the adhesive force against the BA-SUS plate is too large, there is a risk of feeling resistance or pain when peeling off the skin surface after applying the patch. The 90-degree peel test for the BA-SUS plate measures the adhesive strength when a test piece of adhesive material cut out to a width of 15 mm is attached to the BA-SUS plate and peeled off in the 90-degree direction by an Instron type tensile tester. (Average value of n = 3).

[10% tensile strength of the patch]
The sebum-absorbing patch of the present invention has a 10% tensile strength of 0.01 to 1.2 N / in that there is little discomfort during patching (resistance of the patch felt when the skin stretches). A range of 10 mm is preferable. Here, the 10% tensile strength of the adhesive material means that the carrier layer and the separator layer are removed at the time of application to the skin. Therefore, the 10% tensile strength of the laminate comprising the support layer and the adhesive layer is 10%. Means tensile strength. If the 10% tensile strength of the patch is in the range of 0.01 to 1.2 N / 10 mm in both the longitudinal direction and the transverse direction, when the patch is affixed to human skin, the surface direction at the time of application It is easy to adhere along the unevenness | corrugation of fine skin surfaces, such as a skin groove, and can follow the motion of daily skin. In the sebum-absorbing patch of the present invention, it is preferable that the 10% tensile strength in the longitudinal direction and the transverse direction is substantially the same from the viewpoint of the conspicuousness of the patch in the applied state and the reduction in discomfort. Therefore, when the value of 10% tensile strength of the patch is substantially unchanged in the machine direction and the transverse direction (when no anisotropy is observed), the value of 10% tensile strength in the machine direction is What is necessary is just to set it as the value of 10% tensile strength of a patch. The value of the 10% tensile strength of the patch is more preferably in the range of 0.03 to 1 N / 10 mm, still more preferably 0.05 to 0.6 N / 10 mm. If the 10% tensile strength of the patch is too small, the thickness of the elastomer film as the support layer becomes too small, so that the film-forming property and the handleability are deteriorated. If the 10% tensile strength of the patch is too high, the rigidity becomes strong and the stretchability and flexibility are insufficient, so that the patch is less likely to adhere along fine irregularities on the skin surface such as skin grooves, and the applied state Becomes more noticeable. In addition, a patch having an excessively high 10% tensile strength is more uncomfortable when peeled off the skin surface. The 10% tensile strength of the patch is a value measured according to JIS Z0237. Specifically, the patch was stretched by 10% with an Instron type tensile tester, the load (N) at that time was measured, and the obtained value was converted to a width of 10 mm and expressed in units of N / 10 mm ( average value of n = 3).

[Elongation at break of adhesive material]
The sebum-absorbing patch of the present invention preferably has an elongation at break of 200% or more because the patch easily follows the unevenness of the skin. Since the elongation at break of the patch and the carrier layer and the separator layer are removed at the time of application to the skin, this means the elongation at break of the laminate composed of the support layer and the pressure-sensitive adhesive layer. Corresponds to the elongation at break of the support layer. The measuring method of the elongation at break of the patch is as follows. That is, after removing the carrier layer and the separator layer from the patch, a test piece is prepared by cutting into a width of 20 mm and a length of 75 mm along the longitudinal direction (MD). This test piece is attached to an Instron type tensile tester (the load cell uses 10N and 100N) with the chuck interval set to 50 mm. The test piece is pulled at a moving speed of 300 mm / min, the elongation when the test piece is broken is read, and the elongation at break (%) is calculated (average value of n = 3). The elongation at break of the patch is more preferably 250% or more, and still more preferably 300% or more. The upper limit of the elongation at break of the patch is usually 600%. In many cases it is 500%.

[Moisture permeability of adhesive material]
The sebum-absorbing patch of the present invention preferably has a moisture permeability of 1,000 g / m ² · 24 hours or more. When the sebum-absorbing adhesive material has a high moisture permeability, it is possible to prevent the skin from being steamed or sweating when the adhesive material is applied to the skin. The moisture permeability of the sebum-absorbing patch is more preferably 1,300 g / m ² · 24 hours or more, further preferably 1,500 g / m ² · 24 hours or more, and particularly preferably 1,600 g / m ² · 24 hours. This can be done. The upper limit of the moisture permeability of the adhesive material is usually 10,000g ^{/ m} 2 · 24 hr, often 5,000g ^{/ m} 2 · 24 hours. The moisture permeability is measured under the B condition (temperature 40 ° C., relative humidity 90%) defined in JIS Z0208.

6). Manufacturing method of sebum-absorbing patch The sebum-absorbing patch of the present invention is a patch comprising a carrier layer, a support layer, a pressure-sensitive adhesive layer and a separator layer laminated in this order, and the following (a) ~ (E):
(A) the support layer is formed from an elastomeric film;
(B) The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is
b-1) (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms, 50 to 99% by mass,
b-2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms, 0-12% by mass, and b-3) other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester The acrylic copolymer consisting of 1 to 50% by mass of the body [where b-1), b-2) and b-3) are 100% by mass in total. A non-aqueous acrylic pressure-sensitive adhesive containing
(C) The thickness of the support layer is in the range of 1 to 10 μm, the thickness of the pressure-sensitive adhesive layer is in the range of 1 to 15 μm, and the total thickness of the support layer and the pressure-sensitive adhesive layer is in the range of 2 to 20 μm;
(D) the carrier layer is larger than the support layer; and
(E) In an artificial sebum absorption test using triglyceride, the retention force against glass (load 200 g) after triglyceride absorption is in the range of 0.1 to 1 mm / 12 × 20 mm · 1 hour;
As long as a sebum-absorbing patch characterized by the above can be obtained, the production method is not limited. For example, the elastomer film forming the support layer can be formed into a film by an arbitrary forming method such as a solution casting method, an extrusion molding method, a calendar method, and an inflation method. The sebum-absorbing patch of the present invention can be produced as a sheet-like laminate or a roll-like laminate. From the viewpoint of easily producing a stable sebum-absorbing patch, (1) a step of forming a support layer on the upper surface of the carrier layer by a solution casting method, and an adhesive on the upper surface of the separator layer It is preferable to use a method for producing a sebum-absorbing patch comprising a step of coating to form an adhesive layer.

[The step of forming a support layer on the upper surface of the carrier layer by a solution casting method, and the step of forming an adhesive layer by applying an adhesive to the upper surface of the separator layer]
Since the thickness of the support layer is extremely thin, the sebum-absorbing patch of the present invention preferably employs a method of forming a support layer on the top surface of the carrier layer, specifically, on the top surface of the carrier layer, It is preferable that the support layer is formed by a solution casting method in which an elastomer solution for forming the support layer is cast. More specifically, while the carrier layer formed in advance is run in one direction, A support layer continuously formed of an elastomer can be prepared by applying an elastomer solution to the substrate and drying it. According to the solution casting method, it is possible to accurately control the thickness of the elastomer film and to form an elastomer film having a small anisotropy of physical properties depending on the direction of the film.

  Moreover, since the sebum-absorbing patch of the present invention has a very thin pressure-sensitive adhesive layer, it is preferable to employ a method of forming a pressure-sensitive adhesive layer on the upper surface of the separator layer. By applying a pressure-sensitive adhesive that forms a pressure-sensitive adhesive layer on the upper surface of the layer while traveling in one direction, that is, a non-aqueous acrylic pressure-sensitive adhesive, and removing the solvent by drying to form a pressure-sensitive adhesive layer Is preferred.

  A support layer is formed on one side of the carrier layer by a step of forming a support layer on the upper surface of the carrier layer by a solution casting method and a step of applying an adhesive to the upper surface of the separator layer to form an adhesive layer. The laminated body and the laminated body in which the pressure-sensitive adhesive layer is formed on one side of the separator layer are bonded together so that the support layer and the pressure-sensitive adhesive layer are in close contact with each other, whereby carrier layer / support body layer / pressure-sensitive adhesive layer / The sebum-absorbing patch of the present invention comprising the separator layers laminated in this order can be obtained.

  The sebum-absorbing patch of the present invention is prepared by laminating a carrier layer, a support layer, a pressure-sensitive adhesive layer, and a separator layer in this order, for example, by the method described above, and then wound into a roll. A roll-like sebum-absorbing patch may be obtained, or it may be cut into a desired shape, for example, a substantially rectangular or circular shape, to obtain a substantially rectangular or circular sebum-absorbing patch. Further, the sebum-absorbing patch may be obtained by enclosing it in a bag.

7). Use of the sebum-absorbing patch The sebum-absorbing patch of the present invention adheres along the unevenness of the skin surface and the sticking part is not noticeable, and the sticking is maintained for a long time even in a part where sebum secretion is high. Since it is a sebum-absorbing patch, it can be used as a sebum-absorbing patch for acne, where pores (follicles) are inflamed by the interaction of sebum with hormones and bacteria. . In addition, the sebum-absorbing patch of the present invention has the following features: i) Since sebum is secreted more than other parts, sebum tends to accumulate, makeup collapse and tearing are conspicuous, and acne is likely to occur. T-shaped part on nasal muscles, ii) U-shaped parts such as jaws that tend to cause acne in adult men and women with little sebum secretion, i.e., so-called T zone and U zone Or a U-zone sebum-absorbing patch. In particular, when the sebum-absorbing patch of the present invention is used for acne, there is sebum secretion from the acne site and the surrounding skin by applying the patch so as to cover the acne part. However, it is possible to provide a patch that does not peel off for at least 12 hours.

  Furthermore, the sebum-absorbing patch of the present invention can prevent the sebum from accumulating or being damaged at the applied location by applying after removing the sebum after washing the face. By attaching the patch later and applying makeup from the top of the patch, the lower part of the patch can be covered and made inconspicuous, so it can be used as a sebum-absorbing patch for face sticking. . The sebum-absorbing patch of the present invention is more effective when the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer contains a drug such as the above-described sebum absorbent. Further, the sebum-absorbing patch of the present invention is a component in which the adhesive forming the adhesive layer is used in cosmetic applications, such as allantoin, lecithin, amino acids, kojic acid, protein, saccharides, hormones, placenta extract Or extract ingredients such as aloe, loofah, licorice, various vitamins, diphenhydramine hydrochloride, diphenhydramine salicylate, diphenhydramine tannate, triprolidine hydrochloride, mequitazine, chlorpheniramine maleate, clemastine fumarate, promethazine hydrochloride, tranilast, cromoglycic acid Sodium, ketotifen, allyl sulfatase B, bufexamac, flufenamic acid butyl, ibuprofen, indomethacin, aspirin, flurbiprofen, ketoprofen, piroxicam and ibuprofen picone With those containing cosmetic ingredients such as may be used in cosmetic applications. When the sebum-absorbing patch of the present invention is used for cosmetic purposes, it should be affixed to the face (T zone or U zone) as well as the area from the bottom of the eye to the cheek, the neck, the limbs, and their fingers. Is also possible.

  EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples and comparative examples, but the present invention is not limited to these examples. The sebum-absorbing patch of the present invention and the method of measuring the properties and physical properties of each layer provided in the patch are as follows.

[Thickness]
The thicknesses of the sebum-absorbing patch and the carrier layer, support layer, pressure-sensitive adhesive layer, and separator layer included in the patch were measured using a dial thickness gauge.

[Retention force against glass after absorption of triglyceride (load: 200 g) and retention force against glass after absorption of triglyceride (load: 500 g)]
The sebum-absorbing patch was measured for the holding power against glass after absorption of triglyceride (load of 200 g) and the holding power against glass after absorption of triglyceride (load of 500 g) by the following methods. That is, in an atmosphere at a temperature of 23 ° C. and a relative humidity of 50%, triglyceride (Nikko Chemicals Corporation, NIKKOL Triester F810) was dropped on a glass plate with a capillary and stretched uniformly. The test piece cut out from the adhesive material to a width of 12 mm and a length of 50 mm is brought into contact with the adhesive layer and the triglyceride so that the adhesive material and the glass plate are in contact with each other within a range of the test piece width of 12 mm and the length of 20 mm. Then, it was attached to the glass plate, and was reciprocated once with a 2 kg rubber roll at a speed of 300 mm / min (the amount of triglyceride dropped and the range to be stretched were adjusted so that about 4 mg of triglyceride was applied per test piece. ). After standing for 12 hours, in accordance with JIS Z0237, the test piece of the patch is hung so as to hang vertically, a load of 200 g or 500 g is applied, and the deviation length of the test piece after 1 hour has passed (mm) , And the glass holding power of the test piece was determined, respectively, and the glass holding power after absorption of triglyceride of the patch (load 200 g) [hereinafter referred to as “glass holding power after TG absorption (load 200 g)” There is. ] And holding power against glass after absorption of triglyceride (load 500 g) [hereinafter, referred to as “holding power against glass after absorption of TG (load 500 g)”. (Average value of n = 3, unit: mm / 12 × 20 mm · 1 hour). In addition, when even one test piece of the patch was dropped during the measurement of the holding power against glass, this was recorded.

[Value of Cebumeter after peeling of adhesive material]
The method of measuring the value of the cebumeter after peeling the adhesive material of the sebum-absorbing patch (hereinafter sometimes referred to as “the value of the cebumeter after peeling”) is a human skin sebum absorption test performed by the following method: As a part of human skin secreting a large amount of sebum such as the T zone of the face, the sticking property of the patch to the forehead was measured and evaluated. That is, a test piece cut out to a size of 15 mm in width × 50 mm in length from the patch was wiped off the water after face washing of 7 subjects consisting of 5 adult boys and 2 adult women in their 20s to 40s. Pasted on the forehead. After 12 hours, the test piece was peeled off from the applied part, and a sebum (Sebumeter (registered trademark) SM815, manufactured by Curage & Khazaka) was applied to the skin of the forehead where the adhesive material was peeled off. The amount was measured, and the average value of the seven persons was obtained and used as the value of the cebumeter after peeling of the patch for the sebum-absorbing patch. In addition, when there was a subject from whom the patch was dropped before the lapse of 12 hours, or when there was a subject whose sebum amount could not be measured due to cohesive failure of the adhesive, that fact was recorded.

[Adhesion to Bakelite after absorption of triglycerides]
The sebum-absorbing patch was measured for the adhesive strength against bakelite after triglyceride absorption (hereinafter sometimes referred to as “anti-bakelite adhesive strength after TG absorption”) by the following method. That is, in an atmosphere having a temperature of 23 ° C. and a relative humidity of 50%, a triglyceride (Nikko Chemicals Corporation, NIKKOL Triester F810) is placed on a bakelite plate (phenol resin plate, Sumitomo Bakelite Co., Ltd., PL-1102) on a capillary. A test piece cut to 15 mm width x 70 mm length from the patch was pasted on the bakelite plate so that the adhesive layer was in contact with the triglyceride, and a 2 kg rubber roll The pressure was reciprocated once at a speed of 300 mm / min (the amount of triglyceride dropped and the range to be stretched were adjusted so that about 10 mg of triglyceride was applied per test piece). After standing for 12 hours, the peel strength between the patch and the bakelite plate was measured in accordance with JIS Z0237 under the conditions of a peel angle of 90 degrees and a peel speed of 300 mm / min. N / 15 mm) was calculated (average value of n = 3).

[Difficult to notice sticking points]
The seven subjects who performed the above-mentioned human skin sebum absorption test were asked to evaluate the conspicuousness of the sticking point of the patch, and the evaluation of the conspicuousness of the sticking point of the patch was made according to the following criteria.
AA: 6 to 7 people are hardly noticeable.
A: 4-5 people are not easily noticeable.
B: 2 to 3 people are not easily noticeable.
C: One or zero name is not easily noticeable.

[Adhesive residue]
The condition of the adhesive residue at the application site of the adhesive material after peeling the adhesive material of the seven subjects who performed the above human skin sebum absorption test was visually observed. 0 (no adhesive residue), 1 (adhesive residue) 2) (remaining glue residue is more than 1), 3 (remaining adhesive residue), 3 levels are rounded off, and the average value of 7 people is rounded off. It was set as evaluation of the adhesive residue of material.
AA: The average value of 4 stages is 0.
A: The average value of 4 stages is 1.
B: The average value of 4 stages is 2.
C: The average value of 4 stages is 3.

[Peeling resistance]
The seven subjects who conducted the above human skin sebum absorption test were asked to evaluate the peel resistance of the patch after 12 hours of applying the patch, and 0 (no peel resistance), 1 (slight peel resistance) Evaluate in 4 stages of 2 (the peel resistance is greater than 1) and 3 (the peel resistance is large), round off the average value of 7 persons, and evaluate the peel resistance of the patch according to the following criteria: did.
AA: The average value of 4 stages is 0.
A: The average value of 4 stages is 1.
B: The average value of 4 stages is 2.
C: The average value of 4 stages is 3.

[Pain when peeling]
The seven subjects who conducted the above human skin sebum absorption test were asked whether there was any pain when the patch was peeled off after applying the patch for 12 hours. 0 (no pain), 1 (slight pain) ) 2 (I feel pain more strongly than 1), 3 (I feel pain more strongly), I rounded the average value of 7 people, according to the following criteria, pain when peeling the patch It was evaluated.
AA: The average value of 4 stages is 0.
A: The average value of 4 stages is 1.
B: The average value of 4 stages is 2.
C: The average value of 4 stages is 3.

[12 hours adhesion]
Seven subjects who conducted the above human skin sebum absorption test were asked to evaluate the application state of the patch during 12-hour application, and evaluated the adhesiveness of the patch for 12 hours in light of the following criteria.
AA: 6 to 7 people have good adhesion.
A: 4 to 5 people have good adhesion.
B: 2 to 3 people have good adhesion.
C: 1 name or 0 name has good adhesion.

[Adhesive strength (adhesive strength against BA-SUS plate)]
Adhesive strength of the sebum-absorbing patch (for BA-SUS plate adhesive strength) was measured by performing a 90-degree peel test in accordance with JIS Z0237. That is, a test piece of a patch cut into a width of 15 mm and a length of 70 mm was attached to a BA-SUS plate, and the adhesive strength when peeled in a 90-degree direction with an Instron type tensile tester was measured (unit: N / 15 mm) (average value of n = 3).

[10% tensile strength]
The 10% tensile strength of the sebum-absorbing patch was measured in the longitudinal direction (length direction) by using an Instron type tensile tester in accordance with JIS Z0237. 10% elongation, the load (N) at that time was measured, the obtained value was converted to 10 mm width, the 10% tensile strength in the longitudinal direction was measured, and the 10% tensile strength (unit: N / 10 mm) (average value of n = 3).

[Elongation at break]
The method for measuring the elongation at break of the sebum-absorbing patch was as follows. That is, after removing the carrier layer and the separator layer from the patch, a test piece was prepared by cutting into a width of 20 mm and a length of 75 mm. This test piece is attached to an Instron type tensile tester (the load cell uses 10N and 100N) with the chuck interval set to 50 mm. The specimen was pulled in the longitudinal direction (length direction) at a moving speed of 300 mm / min, the elongation when the specimen was broken was read, and the elongation at break (%) was calculated (average value of n = 3).

[Moisture permeability]
The moisture permeability of the sebum-absorbing patch was measured under the condition B (temperature 40 ° C., relative humidity 90%) defined in JIS Z0208 (unit: g / m ² · 24 hours).

[Example 1]
Acrylic copolymer consisting of isononyl acrylate / 2-methoxyethyl acrylate / acrylic acid (mass ratio 68/30/2) on one side of a release paper (silicone-treated polyethylene terephthalate film, thickness 75 μm) forming the separator layer After drying, a solution of ethyl acetate to which 100 parts by mass of Coronate (registered trademark) HL 0.3 parts by mass (manufactured by Nippon Polyurethane Industry Co., Ltd.) is added as a crosslinking agent (the total solid content is about 40% by mass) is dried. The laminate was applied by a bar coating method so that the thickness of the laminate became 10 μm, and then dried to prepare a laminate composed of a separator layer and an adhesive layer.

  On the other hand, a moisture-permeable polyether-type polyurethane elastomer solution for forming a support layer on a polyethylene-side surface of a high-quality polyethylene laminated paper (thickness 90 μm) that forms a carrier layer [Seiko Kasei Co., Ltd., Rack skin (registered trademark) US2268 (Tg = −23.1 ° C.)] is applied by a bar coating method so that the thickness after drying is 5 μm, and then dried to form a carrier layer and a support layer. A laminate comprising: At that time, the polyurethane elastomer solution was applied so that the width of the carrier layer was about 5% wider than the width of the support layer.

  Each laminated body prepared above is integrated so that a support layer and an adhesive layer are bonded together, and a carrier layer / support layer / adhesive layer / separator layer is provided in this order. A patch was obtained. This sebum-absorbing patch was able to facilitate a series of operations for peeling off the carrier layer from the support layer after peeling off the separator layer during use and sticking the adhesive layer to the skin. The patch in the pasted state was in close contact with the fine irregularities on the skin surface such as skin grooves, and did not feel uncomfortable. Holding power against glass after TG absorption of the patch (load 200 g), Holding power against glass after TG absorption (load 500 g), Cebumeter value after peeling, adhesive strength against bakelite after TG absorption, noticeable location Hardness, adhesive residue, peeling resistance, peeling pain, adhesion for 12 hours, adhesive strength against BA-SUS plate, 10% tensile strength, elongation at break, and moisture permeability (hereinafter collectively referred to as "characteristics") Table 1 shows the results of measurement and evaluation.

[Example 2]
A sebum-absorbing patch was obtained in the same manner as in Example 1 except that the acrylic copolymer forming the pressure-sensitive adhesive layer was changed to isononyl acrylate / acrylic acid (mass ratio 98/2). Table 1 shows the results of measurement and evaluation of various properties of the patch.

[Example 3]
Sebum absorbability in the same manner as in Example 1 except that the acrylic copolymer forming the pressure-sensitive adhesive layer was changed to an acrylic copolymer composed of 2-ethylhexyl acrylate / acrylic acid (mass ratio 96/4). A patch was obtained. Table 1 shows the results of measurement and evaluation of various properties of the patch.

[Example 4]
Except having changed the acrylic copolymer which forms an adhesive layer into the acrylic copolymer which consists of 2-ethylhexyl acrylate / vinyl acetate / acrylic acid (mass ratio 85/11/4), it is the same as Example 1. Thus, a sebum-absorbing patch was obtained. Table 1 shows the results of measurement and evaluation of various properties of the patch.

[Example 5]
Example 1 except that the acrylic copolymer forming the pressure-sensitive adhesive layer was changed to an acrylic copolymer consisting of isononyl acrylate / 2-methoxyethyl acrylate / acrylic acid (mass ratio 84/14/2). In the same manner, a sebum-absorbing patch was obtained. Table 1 shows the results of measurement and evaluation of various properties of the patch.

[Example 6]
Except having changed the acrylic copolymer which forms an adhesive layer into the acrylic copolymer which consists of 2-ethylhexyl acrylate / n-butyl acrylate / acrylic acid (mass ratio 88/10/2), an Example In the same manner as in Example 1, a sebum-absorbing patch was obtained. Table 1 shows the results of measurement and evaluation of various properties of the patch.

[Comparative Example 1]
A patch was obtained in the same manner as in Example 1 except that the addition amount of the crosslinking agent was changed to 0.01 parts by mass. Table 1 shows the results of measurement and evaluation of various properties of the patch.

[Comparative Example 2]
A patch was obtained in the same manner as in Example 4 except that the addition amount of the crosslinking agent was changed to 0.01 parts by mass. Table 1 shows the results of measurement and evaluation of various properties of the patch.

[Comparative Example 3]
A patch was obtained in the same manner as in Example 1 except that the addition amount of the crosslinking agent was changed to 4.0 parts by mass. Table 1 shows the results of measurement and evaluation of various properties of the patch.

[Comparative Example 4]
Except having changed the acrylic copolymer which forms an adhesive layer into the acrylic copolymer which consists of 2-ethylhexyl acrylate / n-butyl acrylate / acrylic acid (mass ratio 83/15/2), Example In the same manner as in 6, a sebum-absorbing patch was obtained. Table 1 shows the results of measurement and evaluation of various properties of the patch.

From Table 1, it is a patch comprising a carrier layer, a support layer, a pressure-sensitive adhesive layer, and a separator layer laminated in this order, and the following (a) to (e):
(A) The support layer is formed from an elastomer film; (b) the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is b-1) (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms. 99% by mass, b-2) 0 to 12% by mass of (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms, and b-3) other copolymerizable with the above (meth) acrylic acid alkyl ester The total amount of the acrylic copolymer consisting of 1 to 50% by mass of the vinyl monomer [b-1), b-2) and b-3) is 100% by mass. And (c) the support layer has a thickness of 1 to 10 μm, the adhesive layer has a thickness of 1 to 15 μm, and the support layer and the adhesive layer (D) the carrier layer is larger than the support layer; and (e) the holding power to glass (load 200 g) after TG absorption is 0.1 to 1 mm / 12. It can be confirmed that the sebum-absorbing patch of Examples 1 to 6 has a sebometer value of 3 to 9 and excellent sebum absorptivity after peeling. In addition, since the holding power to glass (load 500 g) after TG absorption is falling to 2.0 mm / 12 × 20 mm · 1 hour, it is confirmed that the feeling of use is good and the adhesive material is hardly noticeable. No peeling residue, no peeling resistance and no peeling pain There is no sense of incongruity, and the adhesive strength to bakelite after TG absorption is 0.2 N / 15 mm or more, excellent adhesion for 12 hours, and adhesive strength to BA-SUS plate, 10% tensile strength, breaking It was found to be a sebum-absorbing patch with a good balance of elongation.

  Moreover, it was confirmed that the sebum-absorbing patch of Examples 1 to 4 was excellent in moisture permeability, and it was found that stuffiness at the time of sticking was prevented. Furthermore, the acrylic copolymer contained in the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer has, as a monomer, 10 mass of b-2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms. %, The sebum-absorbing patch of Example 6 was also confirmed to be excellent in various properties.

  On the other hand, (e) the adhesive materials of Comparative Examples 1 to 3 having a glass holding force (load 200 g) after TG absorption of less than 0.1 mm / 12 × 20 mm · 1 hour or falling are Since the value of the meter was not obtained by cohesive failure or dropping of the patch, it was found that it was not a sebum-absorbing patch. In particular, the adhesive materials of Comparative Examples 1 and 2 having a large adhesive strength against BA-SUS plate and an adhesive strength against bakelite after TG absorption exceeding 1 N / 15 mm have adhesive residue or feel peeling resistance. It turns out that. Moreover, since the adhesive material of Comparative Example 3 having a low adhesive strength against bakelite after TG absorption has poor adhesion for 12 hours and falls off at the time of application, it loses adhesive force when absorbing sebum represented by triglyceride. It was inferred that

  Furthermore, the acrylic copolymer contained in the pressure-sensitive adhesive used as a monomer a large amount of b-2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms. In addition, the adhesive material of Comparative Example 4 showing a large value of 8.1 mm / 12 × 20 mm · 1 hour with respect to glass holding force (load 200 g) after TG absorption has a Cebumeter value of 15 after peeling. Therefore, it was found that even when affixed to the T zone, it is difficult to absorb sebum.

The present invention is a patch comprising a carrier layer, a support layer, an adhesive layer and a separator layer laminated in this order, and the following (a) to (e):
(A) the support layer is formed from an elastomeric film;
(B) The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is
b-1) (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms, 50 to 99% by mass,
b-2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms, 0-12% by mass, and b-3) other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester The acrylic copolymer consisting of 1 to 50% by mass of the body [where b-1), b-2) and b-3) are 100% by mass in total. A non-aqueous acrylic pressure-sensitive adhesive containing
(C) The thickness of the support layer is in the range of 1 to 10 μm, the thickness of the pressure-sensitive adhesive layer is in the range of 1 to 15 μm, and the total thickness of the support layer and the pressure-sensitive adhesive layer is in the range of 2 to 20 μm;
(D) the carrier layer is larger than the support layer; and
(E) In an artificial sebum absorption test using triglyceride, the retention force against glass (load 200 g) after triglyceride absorption is in the range of 0.1 to 1 mm / 12 × 20 mm · 1 hour;
Because it is a sebum-absorbing patch characterized by the fact that it adheres along the unevenness of the skin surface, there is no sense of incongruity during or during application, the application site is not noticeable, and there is a lot of sebum secretion In addition, since it is possible to provide a sebum-absorbing patch that can be stuck for a long time, the industrial applicability is high.

  The present invention also includes a step of forming a support layer on the upper surface of the carrier layer by a solution casting method, and a step of forming an adhesive layer by applying an adhesive to the upper surface of the separator layer. Since it is a manufacturing method of the sebum absorptive patch which performs, since the manufacturing method which can manufacture the said sebum absorptive patch efficiently can be provided, industrial applicability is high.

Claims (15)

A patch comprising a carrier layer, a support layer, an adhesive layer and a separator layer laminated in this order, and the following (a) to (e):
(A) the support layer is formed from an elastomeric film;
(B) The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is
b-1) (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms, 50 to 99% by mass,
b-2) (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms, 0-12% by mass, and b-3) other vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester The acrylic copolymer consisting of 1 to 50% by mass of the body [where b-1), b-2) and b-3) are 100% by mass in total. A non-aqueous acrylic pressure-sensitive adhesive containing

(C) The thickness of the support layer is in the range of 1 to 10 μm, the thickness of the pressure-sensitive adhesive layer is in the range of 1 to 15 μm, and the total thickness of the support layer and the pressure-sensitive adhesive layer is in the range of 2 to 20 μm;
(D) the carrier layer is larger than the support layer; and
(E) In an artificial sebum absorption test using triglyceride, the retention force against glass (load 200 g) after triglyceride absorption is in the range of 0.1 to 1 mm / 12 × 20 mm · 1 hour;
And
The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer contains 0.05 to 3 parts by mass of a crosslinking agent with respect to 100 parts by mass of the acrylic copolymer .
Sebum-absorbing patch.   (B) The acrylic copolymer contained in the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is 60 to 70% by mass of isononyl acrylate, 1 to 5% by mass of a carboxyl group-containing vinyl monomer, and an alkoxy group-containing vinyl monomer. Acrylic copolymer comprising 10 to 40% by mass of the body [however, the total is 100% by mass. The sebum-absorbing patch according to claim 1.   Furthermore, the sebum-absorbing patch according to claim 1 or 2, wherein, in (f) human skin sebum absorption test, the value of the cebumeter after peeling of the patch is 12 or less.   Furthermore, in the artificial sebum absorption test using (g) triglyceride, the adhesive strength against bakelite after triglyceride absorption is 0.2 N / 15 mm or more. Sebum absorptive patch according to any one of claims 1 to 3 Wood. The sebum-absorbing patch according to any one of claims 1 to 4 , wherein the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer does not contain a plasticizer that is liquid at room temperature. The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer contains at least one drug selected from the group consisting of an anti-inflammatory agent, an exfoliating agent, an antibacterial agent, a sebum secretion inhibitor, a rough skin improving agent, and an antioxidant. The sebum-absorbing patch according to any one of 1 to 5 . The sebum absorbing patch according to any one of claims 1 to 6 , wherein the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer contains a sebum absorbent. The sebum-absorbing patch according to any one of claims 1 to 7 , wherein the elastomer film forming the support layer is a polyether type polyurethane elastomer film or a polyester type polyurethane elastomer film. The sebum-absorbing patch according to any one of claims 1 to 8 , wherein a surface of the support layer opposite to the pressure-sensitive adhesive layer side is embossed. The sebum-absorbing patch according to any one of claims 1 to 9 , wherein the patch has a moisture permeability of 1,000 g / m ² · 24 hours or more. 10% tensile strength of the adhesive preparation, sebum absorbent patch material according to any one of claims 1 to 10 in the range of 0.01~1.2N / 10mm. The sebum-absorbing patch according to any one of claims 1 to 11 , which is used for acne. The sebum-absorbing patch according to any one of claims 1 to 12 , which is used for a T zone or a U zone. The sebum-absorbing adhesive material according to any one of claims 1 to 13 , which is used for application after face washing. Forming a support layer by a solution casting method on the upper surface of the carrier layer, and any one of claims 1 to 14 comprising the step of coating the adhesive on the upper surface of the separator layer to form a pressure-sensitive adhesive layer The manufacturing method of the sebum absorptive patch as described in 2.