JP5902815B2 - Acid liquid nutrient - Google Patents

Description

  The present invention relates to an acidic liquid nutrient.

  Enteral nutrition is a physiological route of nutrition via the gastrointestinal tract that can solve the problems associated with high-calorie infusion methods. It is an important nutritional method for difficult patients. Liquid enteral nutrients used for enteral nutrition require that various nutrients necessary for the body (proteins, carbohydrates, lipids, minerals, vitamins, water, etc.) be included in sufficient amounts and in a well-balanced manner. In particular, the majority of elderly people are said to have protein and energy undernutrition (PEM) and hypoproteinemia. It is important.

  Here, in general liquid enteral nutrients, MPC, casein, soybean protein, and the like are used as protein raw materials, but many of the protein raw materials have an isoelectric point on the acidic side. It is. In the protein raw material, protein aggregation or precipitation occurs in the acidic region. Therefore, many of the liquid enteral nutrients currently on the market are of the neutral type with a pH of about 6.5 to 7.5.

  Such enteral nutrients conventionally used may partially aggregate when the protein component comes into contact with gastric juice that is in the acidic range, which tends to cause clogging of the tube and reduce the protein content. It was difficult to increase.

  In the neutral region, since there are many types of microorganisms that can grow, there is a high risk of bacterial contamination and the like, and it is difficult to be suitable for long-term storage. Furthermore, the neutral type tends to be sweet in taste and flavor, has no refreshing flavor variations, and is difficult to ingest continuously.

  Various methods have been studied in the past as methods for stably dispersing proteins even under acidic conditions. For example, a liquid raw material composition containing casein protein, a thermoreversible gelling agent, and an organic acid monoglyceride and having a pH of 3.5 to 4.5 and a water-containing solid substance are filled in a container, and then heated. A method for producing an acidic gel-like food is disclosed (Patent Document 1), characterized in that it is subjected to a treatment and then cooled to cause gelation.

  Moreover, the acid-resistant water which has as a main component fats and oils (A) 20-50 weight%, whey protein (B) 0.5-5.0 weight%, and organic acid monogly (C) 1.0-5.0 weight% Oil-type emulsion composition. Further, in a gel food comprising a gelling agent such as a thickening polysaccharide or gelatin, the acid-resistant oil-in-water emulsion composition is blended in an amount of 5 to 40% by weight in the gel food, and the pH is 3.0. A gel food characterized by adjusting to ˜4.2 has been disclosed (Patent Document 2).

JP2007-049948 JP-A-2004-290120

  As disclosed in Patent Documents 1 and 2 above, various types of acidic-type foods and drinks containing proteins are known. However, in Patent Document 1, storage stability is improved by hardening with a gelling agent. It is a highly gelled food product, and it is difficult to say that protein aggregation is suppressed in the acidic region.

  Patent Document 2 is a gel-like food in which organic acid monoglyceride is an essential raw material and imparts stability by increasing the viscosity, and does not improve protein aggregation itself in the acidic region. It is difficult to say that the stability of the product is satisfactory.

  Accordingly, there has been a demand for a liquid enteral nutrient that is less likely to be clogged with tubes and contaminated with bacteria and that is easy to use.

  An object of the present invention is to provide an acidic liquid liquid food having high protein stability, moderate viscosity, and excellent tube fluidity even under acidic conditions.

  As a result of intensive studies in view of the above problems, the present inventors have found that the above problems can be solved by setting the blending ratio of protein and organic acid, and have completed the present invention. That is, the present invention relates to the following acidic liquid nutrient.

( 1 ) Containing sugar, protein source, lipid, and organic acid, viscosity at 25 ° C. is 10 to 150 mPa · s, pH is 3.0 to 4.0, and measured with a particle size distribution meter Is an acidic liquid liquid food having a mean particle size of 15 μm or less, wherein the protein source is whey protein and / or soy protein, and the blending ratio of the organic acid is 0. as 15 to 0.45 parts, the protein source, the organic acids and other components were mixed, the manufacturing method comprising a stirring solution process.

( 2 ) The method for producing an acidic liquid liquid food according to the above ( 1 ), wherein the organic acid is citric acid or malic acid.

  The acidic liquid nutrient of the present invention is an acidic liquid nutrient that has high stability and does not cause tube clogging even when the nutrient is administered via a tube. Therefore, it is possible to reliably and easily ingest nutrition without the need for readjustment of the flow rate during nursing care.

  The acidic liquid nutrient suitable for the enteral nutrition method of the present invention is characterized in that a carbohydrate, a protein source, a lipid, and a predetermined amount of an organic acid are blended in the nutrient.

  By having such characteristics, unlike conventional acidic liquid nutrients, it has an appropriate viscosity and has excellent stability of the protein source. Thereby, the increase in the gelling agent and emulsifier which has been a problem with the conventional nutrients can be suppressed. For this reason, also when administering via a tube, generation | occurrence | production of the tube clogging during administration can be prevented. Furthermore, since it is an acidic region, there is an effect that the risk of bacterial contamination and the like is reduced.

  Below, the acidic liquid nutrient of this invention is explained in full detail.

(Acid liquid nutrient)
According to one embodiment of the present invention, the acidic liquid nutrient contains a sugar, a protein source, a lipid, and a predetermined amount of an organic acid.

(Organic acid)
The organic acid is not particularly limited, and acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid and the like can be used. These acidulants may be used alone or in combination of two or more. The blending ratio of the organic acid in the acidic liquid nutrient is preferably 0.15 to 0.45 part, more preferably 0.19 to 0.40 part with respect to 1 part of the protein source.

(Nutrient)
Nutrients preferably include carbohydrates, protein sources, and lipids. The nutrient may further contain at least one selected from the group consisting of vitamins, minerals, and dietary fiber as an optional component. The total amount of nutrients in the acidic liquid nutrient is preferably 8 to 60% by mass, and more preferably 15 to 40% by mass.

(Sugar)
Carbohydrates are also called carbohydrates and serve as energy sources. The carbohydrate is not particularly limited as long as it is absorbed into the living body and becomes an energy source, and examples thereof include monosaccharides, disaccharides, and polysaccharides. Specific examples of monosaccharides include glucose (glucose), fructose (fructose), galactose and the like. Specific examples of the disaccharide include sucrose (sucrose), lactose (lactose), maltose (malt sugar), isomaltose, trehalose and the like. Specific examples of the polysaccharide include starch (amylose, amylopectin), dextrin and the like. Of these, dextrin is preferably used.

  Dextrin is a general term for substances in which several α-glucoses are polymerized by glycosidic bonds, and can be obtained by hydrolysis of starch. Since dextrin has a slow degradation rate in the small intestine and is slowly absorbed, it can prevent a rapid increase in blood sugar. Further, by using dextrin, the osmotic pressure of the acidic liquid nutrient can be reduced, and osmotic diarrhea can be prevented. As the dextrin, either a high molecular dextrin having a high degree of polymerization of α-glucose or a low molecular dextrin having a low degree of polymerization of α-glucose may be used, but a high molecular dextrin capable of reducing the osmotic pressure should be used. Is preferred. The low molecular weight dextrin is also called maltodextrin, and usually 3 to 5 α-glucose is polymerized.

  The dextrin may be prepared by itself or a commercially available product may be used. When preparing dextrin, known starches such as corn, waxy corn, wheat, rice, waxy rice, waxy miro, beans (broad beans, mung beans, red beans, etc.), potatoes, sweet potatoes, tapioca, etc. It can be prepared by hydrolysis by a known method. On the other hand, examples of commercially available dextrin include TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.) and the like, which can be suitably used.

  Said saccharide | sugar may be used independently, or 2 or more types may be mixed and used for it. Although content of the saccharide | sugar in an acidic liquid nutrient can be suitably adjusted with the subject to apply, it is preferable that it is 5-30 mass% with respect to the total amount of acidic liquid nutrients.

(Protein source)
The protein source is not particularly limited, and known proteins can be used. Amino acids include essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine; and glycine, alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc. Of the non-essential amino acids. These other, 4-hydroxyproline, 5-hydroxylysine, .gamma.-carboxyglutamic acid, O- phosphoserine, O- phosphotyrosine, N- acetylserine, N ^omega - methyl arginine, pyroglutamic acid, modified amino acid, such as M- formylmethionine; Special amino acids such as ornithine, citrulline, γ-aminobutyric acid (GABA), thyroxine, S-adenylmethionine can also be included. The amino acids may be stereoisomers (enantiomers, diastereomers), positional isomers, or a mixture thereof. Furthermore, the amino acid may be in the form of an inorganic acid salt (hydrochloride or the like), an organic acid salt (acetate or the like), or an ester body (methyl ester or the like) that can be hydrolyzed in vivo.

  As the peptide, one obtained by polymerizing two or more of the above amino acids via a peptide bond (amide bond) can be used. The peptide may be a dipeptide, a tripeptide, an oligopeptide (having about 10 amino acids), or a polypeptide (having several tens to several hundred amino acids). The polypeptide includes proteins such as plant proteins and animal proteins. Some oligopeptides such as lactotripeptide, casein decapeptide, valyltyrosine-containing sadden peptide and the like may have functions such as antihypertensive action.

  Examples of plant proteins include proteins contained in grains such as rice and beans such as soybeans and tofu. The soy protein may have a health function such as binding to bile acid to promote cholesterol excretion.

  Examples of animal proteins include proteins contained in eggs, meat, seafood, milk and the like.

  Among these, it is preferable to use whey protein and soy protein which use milk (whey) as a raw material, and it is more preferable to use whey protein. Examples of whey proteins include whey protein concentrate (WPC), whey protein isolate (WPI), and hydrolyzed whey peptide (WPH). WPC, WPI, soybean protein, and the like may be commercially available. As whey protein, WPC392 (manufactured by Fonterra), WPC80 (manufactured by Fontera), and as soy protein, Prolina (registered trademark) 900 (registered trademark) Fuji Oil Co., Ltd.), Prolina (registered trademark) 300 (Fuji Oil Co., Ltd.) and the like.

  The above protein source, amino acid or peptide may be used alone or in combination of two or more. Although content of the protein source in an acidic liquid nutrient can be suitably adjusted with the subject to apply, it is preferable that it is 2-15 mass% with respect to the acidic liquid nutrient whole quantity.

(Lipid)
Lipids can be a source of energy, biomembrane constituents, steroid hormones and bile acids. The lipid is not particularly limited, and examples thereof include saturated fatty acids, unsaturated fatty acids, vegetable oils, animal fats and oils, and fish oils.

  Examples of saturated fatty acids include caprylic acid, capric acid, lauric acid, palmitic acid, stearic acid and the like.

  Examples of the unsaturated fatty acid include oleic acid, palmitoleic acid, linoleic acid, arachidonic acid, α-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the like. In addition, about EPA and DHA, it can have functions, such as a blood cholesterol raise inhibitory effect and a neutral fat rise inhibitory effect.

  Vegetable oils include coconut oil, corn oil, cottonseed oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, safflower oil (safflower oil), sesame oil, soybean oil, sunflower oil, almond oil, cashew oil, hazelnut Oil, macadamia nut oil, mongolian oil, pecan oil, pine nut oil, pistachio oil, walnut oil, gourd seed oil, buffalo pumpkin oil, pumpkin seed oil, watermelon seed oil, amaranth oil, apricot oil, apple oil, argan oil , Avocado oil, babas oil, moringa oil, borneo oil, cape chestnut oil, cocoa butter, carob oil, kofne palm oil, coriander seed oil, dica oil, flaxseed oil, grape seed oil, hemp oil, kapok seed oil, lale mantia oil , Marula oil, Meadow foam oil, mustard oil, Na Meg butter, okra oil, papaya oil, perilla oil, pequi oil, pine nut oil, poppy oil, pruned oil, quinoa oil, niger seed oil, rice bran oil, Royle oil, Thatcha inchi oil, camellia oil, thistle oil, tomato oil , Wheat oil, sesame oil, sunflower oil, germ oil, coconut oil, peanut oil and the like.

  Examples of animal fats include lard (pig fat), head (tallow), milk fat, and the like.

  Examples of fish oil include fish oil such as mackerel, salmon, yellowtail, sardine, saury.

  Among these, it is preferable to use linoleic acid and α-linolenic acid that cannot be synthesized in vivo by humans, or lipids containing these.

  The above lipids may be used alone or in combination of two or more. Although content of the lipid in an acidic liquid nutrient can be suitably adjusted with the subject to apply, it is preferable that it is 1-8 mass% with respect to the acidic liquid nutrient.

(vitamin)
Vitamins are a general term for organic compounds other than carbohydrates, amino acids or peptides, and lipids that are necessary for maintaining the nutritional state of organisms. Vitamin A (retinol), vitamin D (ergocalciferol, cholecalciferol), vitamin E (tocopherol, tocotrienol) vitamin K (phylloquinone, menaquinone) and other fat-soluble vitamins: vitamin B1 (thiamine), vitamin B2 (Riboflavin), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxal, pyridoxamine, pyridoxine), vitamin B7 (biotin), vitamin B9 (folic acid), vitamin B12 (cyanocobalamin, hydroxocobalamin), vitamin C And water-soluble vitamins such as (ascorbic acid). These vitamins may be used alone or in combination of two or more.

  The vitamin content in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied. Normally, fat-soluble vitamins are added in an amount that does not cause excess disease, and water-soluble vitamins are not limited in the amount added. The preferable content of each vitamin per 100 g of acidic liquid nutrient is as follows.

Fat-soluble vitamin Vitamin A: preferably 0 to 3000 μg, more preferably 20 to 200 μg
Vitamin D: preferably 0.1-50 μg, more preferably 0.1-5.0 μg
Vitamin E: preferably 0.2 to 800 mg, more preferably 1 to 10 mg
Vitamin K: preferably 0.5 to 1000 μg, more preferably 2 to 50 μg

Water-soluble vitamin Vitamin B1: preferably 0.01 to 40 mg, more preferably 0.1 to 10 mg
Vitamin B2: preferably 0.01-20 mg, more preferably 0.05-10 mg
Niacin: preferably 0.1 to 300 mg NE, more preferably 0.5 to 60 mg NE
Pantothenic acid: preferably 0.1 to 55 mg, more preferably 0.2 to 30 mg
Vitamin B6: preferably 0.01-60 mg, more preferably 0.1-30 mg
Biotin: preferably 0.1 to 1000 μg, more preferably 1 to 100 μg
Folic acid: preferably 1-1000 μg, more preferably 10-200 μg
Vitamin B12: preferably 0.01-100 μg, more preferably 0.2-60 μg Vitamin C: preferably 1-2000 mg, more preferably 5-1000 mg

(mineral)
Minerals are elements other than organic compounds that are necessary for maintaining the nutritional state of living organisms. Examples of the mineral include quasi-major elements such as sodium, potassium, calcium, phosphorus and magnesium; essential trace elements such as iron, zinc, copper, iodine, manganese, selenium, chromium and molybdenum. These minerals may be used alone or in combination of two or more.

  Content of the mineral in an acidic liquid nutrient can be suitably adjusted with the subject etc. to apply. The preferable content of each mineral per 100 g of acidic liquid nutrient is as follows.

Semi-major element sodium: preferably 5 to 6000 mg, more preferably 10 to 3500 mg
Potassium: preferably 1 to 3500 mg, more preferably 25 to 1800 mg
Calcium: preferably 10 to 2300 mg, more preferably 30 to 300 mg
Phosphorus: preferably 1 to 3500 mg, more preferably 25 to 1500 mg
Magnesium: preferably 1 to 740 mg, more preferably 10 to 150 mg

Essential trace element Iron: preferably 0.1 to 55 mg, more preferably 1 to 10 mg
Zinc: preferably 0.1-30 mg, more preferably 1-15 mg
Copper: preferably 0.01 to 10 mg, more preferably 0.06 to 6 mg
Iodine: preferably 0.1 to 3000 μg, more preferably 1 to 150 μg
Manganese: preferably 0.01-11 mg, more preferably 0.1-4 mg
Selenium: preferably 0.1 to 450 μg, more preferably 1 to 35 μg
Chromium: preferably 0.1 to 40 μg, more preferably 1 to 35 μg
Molybdenum: preferably 0.1 to 320 μg, more preferably 1 to 25 μg

(Dietary fiber)
Dietary fiber can have functions such as reduced nutrient utilization, reduced plasma cholesterol, improved blood glucose response, improved colon function, and prevention of colon cancer. In addition, dietary fiber may be fermented by intestinal bacteria and converted to short chain fatty acids, carbon dioxide gas, hydrogen gas, methane gas, and the like. Among these, since short chain fatty acids are absorbed in the large intestine, dietary fiber may be an energy source.

  The dietary fiber is not particularly limited, but is insoluble dietary fiber such as cellulose, hemicellulose, lignin, insoluble pectin, chitin, chitosan, psyllium seed, low molecular weight sodium alginate; water-soluble pectin, guar gum, konjac mannan, glucomannan, alginic acid , Agar, chemically modified polysaccharide, polydextrose, indigestible oligosaccharide, maltitol, inulin, carrageenan, wheat bran, indigestible dextrin (eg, Pine Fiber C (manufactured by Matsutani Chemical Co., Ltd.), polydextrose, guar gum decomposition And water-soluble dietary fiber such as food.

  These dietary fibers may be used alone or in combination of two or more. The content of dietary fiber in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied.

(moisture)
The acidic liquid nutrient according to the present invention preferably contains moisture. The water content in the acidic liquid nutrient can be adjusted as appropriate depending on the subject to be applied, the desired viscosity, etc., but is preferably 30 to 90% by mass with respect to the total amount of the acidic liquid nutrient. From the viewpoint, it is more preferably 50 to 90% by mass.

(Other ingredients)
The acidic liquid nutrient according to the present embodiment may further contain other known components such as the following components.

(Health functional ingredient)
A health function component is a component that exhibits a certain function for a living body when ingested. For example, resistant oligosaccharide, sugar alcohol, calcium citrate malate (CCM) and casein phosphopeptide (CPP), chitosan, L-arabinose, guava leaf polyphenol, wheat albumin, bean extract, diacylglycerol, diacylglycerol plant Sterols, soy isoflavones, milk basic proteins and the like.

(Indigestible oligosaccharide)
The indigestible oligosaccharide is a saccharide whose molecular weight is not as large as that of a polysaccharide (about 300 to 3000) among compounds in which a monosaccharide is bound by a glycosidic bond. The indigestible oligosaccharides are not degraded by human digestive enzymes, but those digested by human digestive enzymes can be included in the above-mentioned carbohydrates. Ingestion of indigestible oligosaccharides can provide a bowel regulation effect.

  The indigestible oligosaccharide is not particularly limited, and examples thereof include xylooligosaccharide, fructooligosaccharide, soybean oligosaccharide, isomaltoligosaccharide, dairy oligosaccharide, lactulose, and galactooligosaccharide. These indigestible oligosaccharides may be used alone or in combination of two or more. The content of the indigestible oligosaccharide in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.

(Sugar alcohol)
Sugar alcohol is a kind of sugar produced by reducing the carbonyl group of aldose or ketose, and is poorly absorbed from the small intestine into the body and is not easily caloric. Sugar alcohol is difficult to be metabolized to acid by oral bacteria and can prevent plaque formation. The sugar alcohol can be used as a low calorie sweetener.

  Examples of the sugar alcohol include erythritol, maltitol, palatinose and the like. These sugar alcohols may be used alone or in admixture of two or more.

  The content of the sugar alcohol in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.

  (Calcium citrate malate (CCM) and casein phosphopeptide (CPP)) CCM and CPP can promote calcium resorption and promote bone formation. The CCM and CPP may be used alone or in combination. CCM and CPP are preferably used in combination with calcium. The contents of CCM and CPP in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.

(Food additive)
The food additive is used for the purpose of processing or storing the food by adding, mixing, moistening or other methods to the food. As food additives, in addition to the purpose of fortification, for example, zinc gluconate and copper gluconate, ascorbic acid 2-glucoside, cyclodextrin, preservatives, fungicides, antioxidants, colorants, sweeteners, A pH adjuster, a sour agent, an emulsifier, a fragrance | flavor, etc. are mentioned.

(Zinc gluconate and copper gluconate)
Zinc gluconate and copper gluconate are gluconates utilizing high chelating ability of gluconic acid with heavy metal ions. Since it becomes easy to be absorbed when it is made into the form of gluconate, zinc and copper can be absorbed effectively. The zinc gluconate and copper gluconate may be used alone or in combination. The content of zinc gluconate and copper gluconate in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.

(Ascorbic acid 2-glucoside)
Ascorbic acid 2-glucoside is a compound in which glucose is α-coordinated to the hydroxyl group at the 2-position of vitamin C (ascorbic acid) and is more stable than normal vitamin C because it is not attacked by oxygen. C derivative. Vitamin C can be efficiently absorbed by ascorbic acid 2-glucoside. The content of ascorbic acid 2-glucoside in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.

(Cyclodextrin)
Cyclodextrin is a cyclic oligosaccharide having a cyclic structure in which glucose is bound by a glucoside bond. Those consisting of 6 glucoses are called α-cyclodextrin, those consisting of 7 glucoses are called β-cyclodextrin, and those consisting of 8 glucoses are called γ-cyclodextrin. Cyclodextrins can have functions such as an allergy suppressing effect, a blood sugar level increase suppressing effect, and an emulsifying action. The said cyclodextrin may be used independently or may be used in mixture of 2 or more types. The content of cyclodextrin in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.

(Antioxidant)
The antioxidant has a function of preventing deterioration of the acidic liquid nutrient due to oxidation. Although it does not restrict | limit especially as antioxidant, Ascorbic acid and its sodium salt, erythorbic acid, its sodium salt, etc. may be used. These antioxidants may be used alone or in combination of two or more.

(Coloring agent)
The colorant has a function of beautifying the acidic liquid nutrient. Although it does not restrict | limit especially as a coloring agent, Edible tar pigment | dye (Edible red No. 2, No. 3, No. 40, No. 102, No. 104, No. 105, and No. 106, Edible blue No. 1 and No. 2, Edible yellow No. 4 And No. 5, Edible Green No. 3, etc.), β-carotene, water-soluble anato, chlorophyll derivatives (chlorophyll a, chlorphyll b, copper chlorophyll, copper chlorophyllin sodium, iron chlorophyllin sodium, etc.), riboflavin, iron sesquioxide, titanium dioxide Safflower yellow pigment, cochineal pigment, gardenia yellow pigment, turmeric pigment, red cabbage pigment, beet red, grape skin pigment, paprika pigment, caramel and the like can be used. These colorants may be used alone or in admixture of two or more.

(sweetener)
The sweetener has a function of imparting sweetness to the acidic liquid nutrient. The sweetener is not particularly limited, but saccharin and its sodium salt, xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract Stevia processed sweeteners, thaumatin, curculin, disodium lithyrrhizinate and the like can be used. These sweeteners may be used alone or in combination of two or more.

(PH adjuster)
The pH adjuster has a function of adjusting the pH of the acidic liquid nutrient. The pH adjuster is not particularly limited, and gluconic acid, succinic acid, potassium carbonate, sodium hydrogen carbonate, carbon dioxide, sodium lactate, sodium citrate, adipic acid and the like can be used. These pH adjusters may be used alone or in combination of two or more.

(emulsifier)
The emulsifier has a function of improving the solubility of oil-soluble components such as lipids in water. Although it does not restrict | limit especially as an emulsifier, Synthetic emulsifiers, such as natural emulsifiers, such as a lecithin, saponin, and casein sodium, glycerol fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, etc. are mentioned. These emulsifiers may be used alone or in combination of two or more.

(Fragrance)
The fragrance has a function of flavoring and smelling the acidic liquid nutrient. The fragrance is not particularly limited, but acetophenone, α-amylcinnamaldehyde, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol, decanal, decanol, ethyl acetoacetate, silica Ethyl cinnamate, ethyl decanoate, ethyl vanillin, eugenol, geraniol, isoamyl acetate, isoamyl butyrate, isoamyl phenyl acetate, dl-menthol, l-menthol, methyl salicylate, piperonal, propionic acid, terpineol, vanillin, d-borneol, etc. Can be mentioned. These fragrances may be used alone or in combination of two or more.

(Thickener)
The thickener has a function of imparting an appropriate viscosity to the acidic liquid nutrient, specifically, a viscosity of 10 to 150 mPa · s at 25 ° C. The thickener is not particularly limited, but agar, gelatin, pectin, guar gum, locust bean gum, konjac mannan, xanthan gum, tamarind gum, carrageenan, propylene glycol, carboxymethylcellulose gellan gum, gellan gum, tara gum, tamarind seed gum, psyllium seed Gum, gum arabic, curdlan, pullulan, sodium alginate, tragacanth gum, karaya gum, bee gum, soybean polysaccharide and the like can be used.
These thickeners may be used alone or in admixture of two or more. The content of the thickener in the acidic liquid nutrient is appropriately adjusted in consideration of the viscosity and the like.

(Other ingredients)
Enzymes such as α-amylase, β-amylase, glucoamylase, glucose isomerase, trehalose producing enzyme, trehalose releasing enzyme, glutaminase, yeast, and the like can be used. Content of the said food additive in an acidic liquid nutrient can be suitably adjusted with the subject etc. to apply.

(viscosity)
Moreover, it is preferable that it is 10-150 mPa * s in 25 degreeC, and, as for the viscosity of the acidic liquid nutrient which concerns on this form, it is more preferable that it is 20-120 mPa * s. It is preferable that the viscosity of the acidic liquid nutrient is 150 mPa · s or less because the nasal tube can be flowed in the enteral nutrition method. The viscosity can be adjusted mainly by appropriately setting the content of the stabilizer in the acidic liquid nutrient. In this specification, “viscosity” is a value measured by the method described in the examples.

(Calorie)
Although the calorie | heat amount of the acidic liquid nutrient which concerns on this form changes also with uses of an acidic liquid nutrient, it is preferable that it is 0.5-2.5 kcal / g, and it is 0.5 from a viewpoint of the safety | security of water management. It is more preferably -1.0 kcal / g, but it is more preferably 1.0-2.5 kcal / g when administered to a patient with water restriction, a burn patient, or the like. The amount of heat can be adjusted by appropriately setting the amount of sugar, lipid, protein source, dietary fiber, and the like. In the present specification, the value calculated by the method described in the examples is adopted as the “heat amount”.

(PH)
The pH of the acidic liquid nutrient according to this embodiment is preferably 3.0 to 4.0, and more preferably 3.5 to 3.8. A pH within the above range is preferable because the protein source can be stabilized and an effect of inhibiting bacterial growth can be obtained. In the present specification, “pH” is a value measured by the method described in the examples.

(Average particle size)
The average particle size of the acidic liquid enteral nutrient according to this embodiment is preferably 15 μm or less, and more preferably 10 μm or less. Thus, since the average particle diameter is stabilized at 15 μm or less, the occurrence of tube clogging during administration of a nutrient can be reduced. Here, the average employ | adopts the value measured by the method of the Example mentioned later.

(Use)
The acidic liquid nutrient of the present invention can be used in a tube feeding method, particularly preferably a method of administration via a nasal tube. Administration using a nasal tube is difficult to take orally, and can be targeted for elderly people or sick people with intestinal function.

  The acidic liquid nutrient according to the present invention contains nutrients (carbohydrate, protein source, and lipid), water, and a predetermined amount of organic acid. It is preferable to contain in the quantity which can satisfy | fill demands, such as a required calorie and a nitrogen source. Moreover, it is preferable to set the water content of the acidic liquid nutrient in consideration of the conditions of elderly people and patients to be administered, water management, and the like.

  In addition, the component that can be added is not particularly limited, and may be appropriately set according to the administration method, the state of an elderly person or patient to whom the acidic liquid enteral nutrient is applied, and the like. Moreover, it is preferable that the patient who needs whole body management contains the vitamin and mineral required in order to maintain a nutritional state. In order to improve constipation due to the administration of an acidic liquid enteral nutrient, it is preferable to add dietary fiber to elderly people and the like whose digestive function is lowered.

  The acidic liquid nutrient of this form is adjusted to an appropriate viscosity and contains the necessary nutrients in a well-balanced manner, so swallowing due to elderly people whose stomach has shrunk with aging, cerebrovascular disorders, neuromuscular disorders, etc.・ For patients with impaired chewing ability, patients who have difficulty in oral intake due to disturbance of consciousness, etc., for the treatment of gastrointestinal tract function, post-surgical patients, etc., for undernutrition, for prevention / treatment of reflux esophagitis, error Suitable for the prevention and treatment of aspiration pneumonia. In the administration, there is a risk of diarrhea and gastroesophageal reflux, but it has been forced to administer for a long time, but the use of the acidic liquid nutrient according to this form reduces the risk of bacterial contamination during administration, and the patient's QOL It is expected to be very useful for improvement and improvement of work efficiency in the nursing / nursing field.

(Method for producing acidic liquid nutrient)
The acidic liquid nutrient according to the present invention can be produced by a known method. For example, it can be produced by adding nutrients, a predetermined amount of organic acid, and other desired components to warm water and stirring. Also, a solution in which nutrients are dissolved in warm water and a solution in which organic acids are dissolved in water are prepared, and nutrients and other desired components are added to any of them, and the two solutions are mixed and stirred. Can be manufactured.

  The obtained acidic liquid nutrient can be made into a product by, for example, filling the container after continuous sterilization. Although it does not restrict | limit especially as the method of the said continuous sterilization, Ultra high temperature short time (UHT) sterilization, hot water sterilization, batch type sterilization, and these combination are mentioned. The sterilization is preferably performed in a short time. By performing sterilization in a short time, deterioration of components contained in the acidic liquid nutrient can be suppressed.

  It does not specifically limit as a container filled with an acidic liquid nutrient, A well-known container may be used. Examples of the container include a tetrapack, a cart can, a glass container, a metal can, an aluminum pouch, and a plastic container. Of these, it is preferable to use a plastic container.

  As a raw material of the plastic container, polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyvinyl acetate (PVAc), polycarbonate (PC), polybutylene terephthalate (PBT), polyethylene terephthalate (PET), Polyethylene naphthalate (PEN), ethylene-vinyl acetate copolymer (EVA), ethylene-α-olefin copolymer, polyfluorocarbon, polyimide and the like are preferably used.

  The plastic container further includes polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, and the like. Gas barrier resin layer: Gas barrier inorganic layers such as an aluminum foil, an aluminum vapor deposition film, a silicon oxide film, and an aluminum oxide film may be used in appropriate combination. By providing the gas barrier layer, deterioration of the acidic liquid nutrient due to oxygen, water vapor, or the like can be prevented.

  The container may be further shielded from light. By the light shielding, for example, deterioration due to light of vitamin A, vitamin B2, vitamin C, vitamin K and the like which can be contained in the acidic liquid nutrient can be suppressed.

  Commercially available containers may be used, for example, soft pouches (manufactured by Fuji Seal Co., Ltd.), bottled pouches (manufactured by Toppan Printing Co., Ltd.), spouches (manufactured by Dai Nippon Printing Co., Ltd.), cheer packs (co., Ltd.) Hosokawa Yoko) etc. can be used.

  EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited thereto. In addition, although the display of "part" or "%" is used in an Example, unless otherwise indicated, "mass part" or "mass%" is represented.

(Examples 1 to 11)
The preparation method at the time of 6000g preparation is described below. The blending amount of each raw material is as shown in Table 1-1 and Table 1-2. 2000 g of prepared water was weighed in a 10 L stainless steel bucket and heated to 50-60 ° C. in a hot water bath. Subsequently, antifoaming agent (Awabreak G-109 (manufactured by Taiyo Kagaku Co., Ltd.)), whey protein (WPC392 (manufactured by Fonterra)), soybean protein (Prolina (registered trademark) 900 (manufactured by Fuji Oil Co., Ltd.)), sugar Quality dextrin (TK-16 (manufactured by Matsutani Chemical Co., Ltd.)) and super white sugar were added. To the solution, lipid, glycerin fatty acid ester as an emulsifier, soybean polysaccharide (Soya Five-S-DN (manufactured by Fuji Oil Co., Ltd.)), and pectin were added and mixed. Furthermore, as vitamins, water-soluble vitamin mix and fat-soluble vitamin mix, minerals as calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate and tripotassium citrate, yeast as yeast mix, organic acid As citric acid and malic acid, ascorbic acid, fragrance and the like were appropriately added and stirred. Water was added until the obtained mixed solution became 6000 g, and dissolved and dispersed until a uniform state was obtained.

  The obtained solution was continuously sterilized, filled into an aluminum pouch with a stopper so that the amount was 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, an acidic liquid nutrient containing a pouch was produced by cooling.

  The total energy was calculated as (4 Kcal × sugar content) + (9 Kcal × lipid content) + (4 Kcal × protein source content), and the calorie was shown as Kcal per g sample.

(Table 1-1)

(Table 1-2)

(Comparative Examples 1-6)
The preparation method at the time of 6000g preparation is described below. The amount of each raw material is as shown in Table 2. 2000 g of prepared water was weighed in a 10 L stainless steel bucket and heated to 50-60 ° C. in a hot water bath. Subsequently, antifoaming agent (Awabreak G-109: manufactured by Taiyo Kagaku Co., Ltd.), whey protein (WPC392 (manufactured by Fonterra)), and dextrin (TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.)), super white sugar To the solution, lipid, glycerin fatty acid ester as an emulsifier, and soybean polysaccharide (Soya Five-S-DN (Fuji Oil Co., Ltd.)) were added and mixed. Vitamin mix and fat-soluble vitamin mix, as minerals, calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate and tripotassium citrate, as yeast, yeast mix, as organic acid, citric acid, etc. Ascorbic acid, fragrance and the like were appropriately added and stirred. If liquid water was added until 6000 g, it was dissolved and dispersed into a homogeneous state.

  The obtained solution was continuously sterilized, filled into an aluminum pouch with a stopper so that the amount was 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, an acidic liquid nutrient containing a pouch was produced by cooling.

(Table 2)

  Properties of the obtained acidic liquid nutrients (Examples 1 to 11 and Comparative Examples 1 to 6) were observed, and various physical properties were evaluated. The evaluation method is as follows.

  (1) The pH was measured using a pH meter METTLER TOLEDO MP220 (METTLER TOLEDO) after leaving the acidic liquid nutrient at 25 ° C. for 24 hours.

  (2) Viscosity was determined by allowing the acidic liquid nutrient to stand at 25 ° C. for 24 hours, and then rotating the B-type rotational viscometer (manufacturer: BROOKFIELD, model: DV-II + Pro, measurement conditions: rotational speed 60 rpm, measurement time 1 min, rotor No. 61, Measurement temperature Room temperature (25 ° C.)).

  (3) The average particle size was measured using a laser diffraction type particle size distribution analyzer SALD7000 (Shimadzu Corporation).

(4) Stability was determined by visually checking the separated state of the acidic liquid nutrient after standing the acidic liquid nutrient at room temperature for 7 days, and judging the stability of the liquid. The stability was judged according to the following evaluation criteria.
○: No separation was observed in the nutrient solution, and stability was maintained.
Δ: Slight sediment is seen on the bottom of the nutrient container.
X: Clear separation is observed in the nutrient solution.

(5) The amount of precipitation was measured by weighing 40 g of acidic liquid nutrient into a 50 mL falcon conical tube (Falcon), centrifuging at 3000 rpm for 10 minutes with a centrifuge Hitachi CF9RX (Hitachi), and then supernatant. And the weight of the precipitate remaining in the tube was measured.
○: The amount of the precipitate is 2.0 g or less Δ: The amount of the precipitate is less than 4.0 g ×: The amount of the precipitate is 4.0 g or more

(6) Tube fluidity is measured by measuring about 200 mL of sample with a measuring cylinder and transferring it to an enteral nutrition bottle (manufactured by Terumo Corporation). A feeding tube (manufactured by Nipro Co., Ltd.) having a length of 100 cm was connected, and the fluidity of the nutrient was evaluated at a flow rate of 300 mL / hr.
○: There is no tube clogging and the entire amount can be flowed.
Δ: Tube clogging occurs within 30 minutes after the start of flow, and the entire amount cannot be flowed.
X: Viscosity is high and cannot flow through a nasal tube.

  The results are shown in Table 3 below.

(Table 3)

  Although the nutrients of Examples 1 to 11 had a viscosity comparable to that of the nutrients of Comparative Examples 3 to 6, for example, the amount of precipitation was small and the tube fluidity was excellent. From this, it can be understood that the stability of the protein under acidic conditions is not simply caused by the addition of a stabilizer or the like, but it is important to add a predetermined amount of an organic acid.

  From the above results, the nutrients of Examples 1 to 11 had an appropriate viscosity, a small amount of precipitation, and good stability. In addition, stability was maintained over time, and tube fluidity was good.

  The acidic liquid nutrient according to the present invention contains nutrients (sugars, protein sources and lipids), moisture, and a predetermined amount of organic acid, and is supplied via a tube feeding method, particularly via a nasal tube. The present invention has industrial applicability as a nutrient that is preferably used in a method to be administered.

Claims (2)

Average particle when measured with a particle size distribution meter, containing sugar, protein source, lipid, and organic acid, having a viscosity at 25 ° C. of 10 to 150 mPa · s, pH of 3.0 to 4.0 A method for producing an acidic liquid liquid food having a diameter of 15 μm or less, wherein the protein source is whey protein and / or soy protein, and the blending ratio of the organic acid is 0.15 to 0 parts per 1 part of the protein source. as .45 parts of the protein source, the organic acids and other components were mixed, the manufacturing method comprising a stirring solution process. The method for producing an acidic liquid liquid food according to claim 1 , wherein the organic acid is citric acid or malic acid.