JP5872752B2 - Hair nourishing agent with ability to dissolve sebum cured product - Google Patents

Description

The present invention relates to a hair nourishing agent having a sebum cured product dissolving ability used for scalp.

  Conventionally, various scalp compositions have been developed, such as a hair nourishing agent for promoting or maintaining hair growth, and a hair tonic that gives a refreshing feeling to the scalp.

  Many of these scalp compositions, for example, for hair growth purposes, impregnating the scalp with nutrients and supplying nutrients to the hair roots, hair follicles, hair matrix cells, etc. The hair growth is promoted.

  However, the scalp has a lot of sebum and exfoliated keratin that are generated due to the metabolic activity of the skin, which prevents the penetration of nutrients into the scalp and cannot produce a sufficient hair nourishing effect. There was a case.

  Then, the composition for scalp which improved the hair-restoration effect is known by removing the sebum of the scalp, exfoliated keratin, etc., and promoting penetration of a nutrient ingredient to the scalp (for example, refer to patent documents 1). .)

  According to the scalp composition capable of removing sebum and exfoliated exfoliation from the scalp, the hair nourishing effect can be further exhibited.

JP-A-8-12529

  However, the conventional scalp composition can remove sebum and dirt on the surface of the scalp, but sebum hardening that has hardened over time due to a mixture of sebum, keratin, dust and dust adhering to the scalp. Once an object was formed in the pores, it was difficult to remove it.

The present invention was made in view of such circumstances, sebum can be sufficiently removed sebum cured product, supplying root and hair follicles, the nutrients in the hair matrix cells efficiently A hair nourishing agent having a cured product dissolving ability is provided.

Above to solve the conventional problems, the hair tonic having a dissolving ability of sebaceous cured for closing the pores of the present invention, the component with the nutrients to encourage growth of the hair to extend the capillaries of the scalp, carbon A sebum-dissolving component that contains a hydroxycarboxylic acid having 1 to 6 and dissolves a sebum cured product secreted from the scalp, and at least one carbon number selected from coumaric acid, ferulic acid, and benzylic acid is 9 The component containing 0.01 to 10% of the above hydroxycarboxylic acid and expanding the capillaries of the scalp, such as assembly extract, ginkgo biloba extract, kina extract, ginger root extract, clove extract, chimpi extract, spruce extract, capsicum tincture, Nicotinic acid or its derivatives, garlic extract, yuzu extract, acetylcholine, carpronium chloride, γ-oryzanol, chroma Rim, cercretin, cephalanthin, nicorandil, vitamin E or derivatives thereof, biotin, pinacidil, hinokitiol, minoxidil, carrot extract, sophora extract, benzyl nicotinate, nicotinamide, mint extract, clara extract, senkyu extract, ginger extract, It was decided to contain at least one selected from ashitaba extract, ginseng extract, camphor, peony extract, birch extract, sage extract, and niacinamide .

Moreover, in invention of Claim 2 , in the hair nourishing agent which has the solubility of the sebum hardened | cured material which obstruct | occludes the pore of Claim 1 , the said C1-C6 hydroxycarboxylic acid is citric acid, lactic acid, It is also characterized in that it is any one selected from glycolic acid, malic acid, tartaric acid, and mevalonic acid, or a mixture of two or more thereof.

According to the invention described in claim 1, and a component in the nutrients to encourage growth of the hair to extend the capillaries of the scalp, carbon atoms and containing hydroxy carboxylic acid having from 1 to 6, secreted from the scalp A sebum dissolving component that dissolves a cured product of sebum, and 0.01 to 10% of a hydroxycarboxylic acid having at least one carbon number of 9 or more selected from coumaric acid, ferulic acid, and benzylic acid . Ingredients that expand capillaries include assembly extract, ginkgo biloba extract, kina extract, ginger root extract, clove extract, chimpi extract, spruce extract, red pepper tincture, nicotinic acid or its derivatives, garlic extract, yuzu extract, acetylcholine, carpronium chloride, γ- Oryzanol, cromakalim, cercretin, cephalanthin, nicorandil, vitamin E or Derivatives of biotin, pinacidil, hinokitiol, minoxidil, carrot extract, sophora extract, benzyl nicotinate, nicotinic acid amide, mint extract, clara extract, nematode extract, ginger tincture, ashitaba extract, ginseng extract, camphor, peony extract, Since it contains at least one selected from birch extract, sage extract, and niacinamide , the sebum cured product can be sufficiently removed, and nutrients are efficiently applied to the hair roots, hair follicles, and hair matrix cells. It is possible to provide a hair nourishing agent having the ability to dissolve a sebum cured product that closes pores that can be supplied .

According to the invention described in claim 2 , the hydroxycarboxylic acid having 1 to 6 carbon atoms is any one selected from citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, and mevalonic acid, or Since it is a mixture of two or more of these, the water-soluble soil component that forms the sebum cured product can be efficiently removed by gently stimulating the scalp without excessive irritation.

  The present invention is a sebum dissolving agent that contains at least one of a nutritional component that promotes hair growth, a hydroxycarboxylic acid having 1 to 6 carbon atoms, and a plant extract, and dissolves a cured product of sebum secreted from the scalp. The present invention provides a scalp composition comprising a component and a hydroxycarboxylic acid having 7 or more carbon atoms.

  Conventionally, when performing hair growth of hair with a hair nourishing agent or the like, it has been known that a sebum cured product that blocks pores prevents the penetration of nutrient components, but a method for effectively removing this sebum cured product is still not available. It was not known.

  That is, with conventional hair nourishing agents, it was possible to supply nutrients from the scalp surface into the scalp by removing sebum and dirt on the scalp surface, but to penetrate the nutrients from the pores in the immediate vicinity of the hair It was not possible to carry out effective hair restoration.

  Therefore, in the medical field in particular, so-called mesotherapy is performed in which a nutrient component is injected by puncturing a plurality of portions of the scalp with a hollow fine needle.

  However, this mesotherapy is a medical practice and is not easily performed by an individual, and it is difficult to personally supply nutritional components near the hair roots, hair follicles, and hair matrix cells.

  On the other hand, according to the scalp composition according to the present invention, it is possible to efficiently remove the sebum cured product, particularly the sebum cured product formed in the pores, which was difficult to remove with the conventional scalp composition. Therefore, nutrient components can be supplied to hair roots, hair follicles, and hair matrix cells.

  In other words, by supplying pores, hair follicles, and hair matrix cells using the pores that originally existed in the scalp without puncturing the scalp, the hair restoration effect similar to that of mesotherapy is achieved. It can be said that it was made to do.

  In addition, the scalp composition according to the present invention has the characteristics that there is little excessive irritation to the scalp, low risk of causing inflammation and the like, and low risk of direct damage to the hair. From young people to the elderly, it can be widely used by those who are concerned about thinning hair.

  Further, while the sebum cured product is efficiently dissolved, the sebum once dissolved does not form a cured product again, so that the sebum cured product formed on the skin can be efficiently removed.

  Here, the hydroxycarboxylic acid having 1 to 6 carbon atoms gently peels off the old stratum corneum present on the surface of the scalp and has a relatively high water solubility, so it has a role of removing water-soluble dirt in the pores. To fulfill.

  The hydroxycarboxylic acid having 1 to 6 carbon atoms is preferably, for example, any one selected from citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, and mevalonic acid, or a mixture thereof.

  By using these components, in addition to the effects described above, the scalp can be gently stimulated to promote keratin regeneration.

  In addition, you may make it add (beta) -hydroxy acids, such as salicylic acid, as a sebum melt | dissolution component, for example. β-Hydroxy acid also gently peels off old stratum corneum present on the surface of the scalp, but it is relatively oil-soluble (low water-solubility), so oil-soluble oils such as sebum fixed in the pores. It plays the role of removing dirt.

  The plant extract is not particularly limited as long as it can dissolve the sebum-cured product, for example, life-prolonging grass, hypericum, barley, orange, cucumber, burdock, shiitake mushroom, dill, duke, cordyceps, loquat, grape leaves, prunes Extracts such as loofah, maikai, lily, and apple can be used.

The hydroxycarboxylic acid having 7 or more carbon atoms plays a role of promoting dissolution of the sebum cured product by cooperating with the aforementioned sebum dissolving component. Examples of the hydroxycarboxylic acid having 7 or more carbon atoms include mandelic acid (C ₈ H ₈ O ₃ ), coumaric acid (C ₉ H ₈ O ₃ ), caffeic acid (C ₉ H ₈ O ₄ ), and ferulic acid. (C ₁₀ H ₁₀ O ₄ ) and benzylic acid (C ₁₄ H ₁₂ O ₃ ) can be suitably used.

  When the hydroxycarboxylic acid having 7 or more carbon atoms is contained in the scalp composition in an amount of about 0.01 to 10%, the ability to dissolve sebum-cured products of the sebum-dissolving component can be dramatically improved.

  Further, in the composition for scalp described above, as a component for expanding the capillaries of the scalp, assemblage extract, ginkgo biloba extract, kina extract, ginger root extract, clove extract, chimpi extract, spruce extract, red pepper tincture, nicotinic acid or its Derivatives, garlic extract, yuzu extract, acetylcholine, carpronium chloride, γ-oryzanol, cromakalim, cerretin, cephalanthin, nicorandil, vitamin E or its derivatives, biotin, pinacidil, hinokitiol, minoxidil, carrot extract, sophora extract, benzyl nicotinate, nicotine Acid amide, mint extract, clara extract, senkyu extract, ginger tincture, ashitaba extract, ginseng extract, camphor, peonies extract, birch extract, se Jiekisu, may contain at least any one selected from niacinamide.

  By using these ingredients, it is possible to gently promote blood flow while reducing the possibility of inflammation in the scalp, and to the hair roots, hair follicles, and hair matrix cells through the capillaries surrounding the hair roots. Nutritional components can be supplied efficiently.

In the composition for scalp, as a hair active ingredient that stimulates the root of hair and promotes growth, panthenol, yeast extract, typhoid extract, chixetsu carrot extract, ginseng extract, placenta extract, royal jelly extract, adenosine triphosphate disodium, potassium aspartate, pentadecanoic acid glyceride, data Canard, ethyl pantothenate, iodide garlic extract, minoxidil, hinokitiol, Ala emissions Knights Inn, run-Bhutan extract, biotin (vitamin H), midnight sun comb extract, It is good also as containing at least any one chosen from t-flavanone.

  By using these ingredients as hair active ingredients, the capacity of the hair follicle on the recipient side of the nutritional ingredients is improved, and the nutritional ingredients are efficiently absorbed by the hair roots, hair follicles and hair matrix cells, The hair effect can be further generated.

  In addition, the composition for scalp has a sebum cured product dissolution promoting component, a moisturizing component, a hair growth promoting component, an antiandrogen hormone component, an ultraviolet protection component, a deodorizing component, a hair production cycle improving component, a scalp softening component, a cell activation component. You may make it add a component, a scalp environment improvement component, etc.

  As moisturizing ingredients and hair growth promoting ingredients, for example, button pi extract, achacha extract, hypericum extract, coleus extract, masaki extract, kouca extract, maikai flower extract, chorei extract, hawthorn extract, rosemary extract, duke extract, chamomile extract, Nettle extract, litchi extract, yarrow extract, aloe extract, maroni extract, asunaro extract, hibermata extract, osmoin extract, oat extract, tuberose polysaccharide, cordyceps extract, barley extract, orange extract, sorghum extract, PCA menthyl , And the like selected from the salamander extract and the Yokuinin extract. The above active ingredients may be used alone or in combination of two or more.

The antiandrogenic component and ultraviolet protective component or deodorant components, benzophenones, cinnamic acids, aminobenzoic acids, benzotriazoles, Ryoku tea extract, rosemary extract, click Waekisu, Clara extract, rose extract, apple extract, mugwort extract, lemon extract, lime extract, ginseng extract, eucalyptus extract, Scutellaria root extract, parsley extract, and the like can be mentioned those selected Dokudamieki scan or et al. The above active ingredients may be used alone or in combination of two or more.

  Hair production cycle improving component, scalp softening component, cell activation component and scalp environment improving component include salamander extract, vitamins, brown algae extract, choline, ginkgo biloba extract, essential fatty acid, eicosatrienoic acid, female hormone, Examples include corticosteroids, antihypertensive agents, TCA cycle-related substances, and various amino acids. The above active ingredients may be used alone or in combination of two or more.

  Needless to say, the component added to the scalp composition may be added to the scalp composition as long as it is a component generally used as a hair nourishing agent, hair technic or the like.

  By the way, since the composition for scalp which concerns on this invention is set as the above-mentioned composition, the effect that the irritation | stimulation with respect to skin can be reduced relatively can be effectively dissolved while sebum solidified substance can be dissolved efficiently. Have.

  Specifically, conventionally known hair nourishing agents and hair arts for dissolving sebum often contain, for example, about 70 to 80% ethanol.

  Although this ethanol is effective in dissolving sebum, it is highly irritating to the skin and may cause rough skin.

  Also, when a hair nourishing agent or hair artic acid containing high concentration of ethanol is dropped or applied to the head, if the amount of liquid is large, it may flow down to the face, but the liquid that flows down adheres to the facial skin. It may cause rough skin and may cause considerable pain when it enters the eyes.

  On the other hand, according to the composition for scalp according to the present invention, even if the ethanol content is 50% or less, for example, the sebum cured product can be dissolved with high efficiency. Therefore, the scalp, facial skin, and finger skin are stimulated. It has the advantage that it can be reduced as much as possible and the hair nourishing effect can occur safely.

  Next, preparation of the composition for scalp which concerns on this embodiment is described. Hereinafter, as an embodiment according to the present invention, a hair nourishing agent will be described as an example.

[Preparation of hair nourishing agent]
First, hair nourishing agents A to D (four types) according to the present invention, which were blended with the components shown in the formulation table shown in Table 1 below, were prepared according to a conventional method. Each hair nourishing agent A to D has a different carbon number in the hydroxycarboxylic acid having 7 or more carbon atoms.

[Preparation of comparative hair nourishing agent]
Next, a hair nourishing agent Z for comparison with which the ingredients shown in the recipe shown in Table 2 were blended was prepared according to a conventional method.

[Comparison test 1]
Using the aforementioned hair nourishing agents A to D and the hair nourishing agent Z, a sebum cured product suppression test using rabbit ears was performed according to the following method.

  First, linseed oil was applied for 14 days to the ears of 12 rabbits that had been trained and trained for one week to induce a cured sebum.

  Subsequently, the rabbits were divided into 6 test groups and 6 comparative control groups, respectively, and for the test site, the right auricle was used as a control (no treatment), and the left auricle was used as a sample application site.

  Hair test agent A to D was applied to the test group, and hair test agent Z was applied to the control group on the 15th day, and the test was conducted for 7 days by the method of Klingman & Milss, and the average value was calculated from the obtained data and evaluated. went. The determination criteria are as shown in Table 3.

  Table 4 shows the results obtained according to the criteria.

  As shown in Table 4, the sample application site (left auricle) of each individual of the comparative control group to which the hair nourishing agent Z was applied did not show a significant change compared to the control (right auricle). On the other hand, the sample application site (left auricle) of each individual in the test group showed an effect of suppressing sebum cured products from the first day as compared to the control (right auricle), and the sebum hardening over time thereafter. As a result, the product was remarkably suppressed. Among these, the hair nourishing agent C significantly suppressed the sebum cured product.

  Thus, from the result of this comparative test 1, it was shown that the hair nourishing agent which concerns on this embodiment can fully remove sebum hardened | cured material.

[Comparison test 2]
Next, using the above-mentioned hair nourishing agents A to D and the hair nourishing agent Z, a hair growth test for humans was performed.

  The test was conducted by dividing 90 subjects suffering from hair loss into two groups, a test group and a comparative control group. The test group was further divided into 18 groups each of 4 groups: test group A using hair nourishing agent A, test group B using hair nourishing agent B, test group C using hair nourishing agent C, and test group D using hair nourishing agent D. . On the other hand, the comparative control group using the hair nourishing agent Z was also assigned 18 people. In each group, a hair nourishing agent was used twice a day (morning and night) for 3 months to evaluate the hair growth state.

  Hair growth evaluation was performed by the double blind method, and evaluation was performed according to the determination table shown in Table 5.

  Table 6 shows the results of the evaluation thus performed.

  As shown in Table 6, in the comparative control group, invalidity was 6 (33.3%), somewhat effective was 9 (50.0%), effective was 3 (16.7%), and extremely effective Although there were 0 (0.0%), in the test group A, the invalidity was 5 (27.8%), the slightly effective was 9 (50.0%), and the effective was 2 (11.1). %), 2 extremely effective (11.1%), and in test group B, 2 invalid (11.1%), 9 slightly effective (50.0%), 3 effective (16.7%), extremely effective is 4 persons (22.2%), and in test group C, invalidity is 0 persons (0.0%), somewhat effective is 3 persons (16.7%), Effectiveness is 4 (22.2%), extremely effective is 11 (61.1%), and in the test group D, invalidity is 0 (0.0%) and somewhat effective is 5 (27.27%). 8%), effective 4 people (2 .2%), are very effective nine (50.0%), tonic A~D was suggested to be very effective in hair growth. In particular, the sum of the scores indicates that the hair nourishing agents B to D are particularly effective.

  This is considered to be a result of effectively removing the sebum cured product and confirming that the nutritional components are efficiently absorbed into the scalp as seen in the results of Comparative Test 1.

  As described above, in the composition for scalp according to the present invention, a nutrient component that promotes hair growth, a hydroxycarboxylic acid having 1 to 6 carbon atoms, and a sebum-dissolving component of at least one of plant extracts, Since it was decided to contain a hydroxycarboxylic acid having 7 or more carbon atoms, it was possible to effectively remove the sebum cured product that had been difficult to remove from the pores in the past, and to supply nutrients to the hair, Efficient hair nourishment can be performed.

  Finally, the description of each embodiment described above is an example of the present invention, and the present invention is not limited to the above-described embodiment. For this reason, it is a matter of course that various modifications other than the above-described embodiments can be made according to the design and the like as long as they do not depart from the technical idea according to the present invention.

Claims (2)

A component that extends the capillaries of the scalp as a nutritional component to promote the growth of hair,
A sebum-dissolving component that contains a hydroxycarboxylic acid having 1 to 6 carbon atoms and dissolves a cured product of sebum secreted from the scalp;
At least any one selected from coumaric acid, ferulic acid, and benzylic acid is 0.01 to 10% of hydroxycarboxylic acid having 9 or more carbon atoms,
Ingredients that expand the capillaries of the scalp are as follows: assembly extract, ginkgo biloba extract, kina extract, ginger root extract, clove extract, chimpi extract, spruce extract, red pepper tincture, nicotinic acid or derivatives thereof, garlic extract, yuzu extract, Acetylcholine, carpronium chloride, γ-oryzanol, cromakalim, cerretin, cephalanthin, nicorandil, vitamin E or derivatives thereof, biotin, pinacidil, hinokitiol, minoxidil, carrot extract, sophora extract, benzyl nicotinate, nicotinamide, mint extract, Clara Extract, Senkyu extract, Pepper tincture, Ashitaba extract, Panax ginseng extract, Camphor, Peonies extract, Birch extract, Sage extract, Niacin Containing at least any one selected from bromide, hair tonic having a dissolving ability of sebaceous cured for closing the pores.   The hydroxycarboxylic acid having 1 to 6 carbon atoms is any one selected from citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, and mevalonic acid, or a mixture of two or more thereof. The hair nourishing agent which has the solubility of the sebum hardened | cured material which obstruct | occludes the pore of Claim 1.