JP5855926B2 - Dentifrice in a container - Google Patents

Description

  The present invention relates to a dentifrice in a container.

The main component of the tooth is hydroxyapatite (Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ ), and in the mouth, usually elution (decalcification) of phosphate ions and calcium ions, and crystals to calcium phosphate and hydroxyapatite The calcification (remineralization) is in equilibrium. In the early days of worm teeth, demineralization occurs in the enamel on the surface of normally transparent teeth, resulting in white spots. At this stage, if fluorine ions or calcium ions are present on the tooth surface, remineralization by fluorine ions or calcium ions is promoted, and as a result, the aforementioned vitiligo disappears and the enamel can be re-transparent. .

  When these fluorine ions and calcium ions are mixed in the same dentifrice, they react during storage to produce calcium fluoride fine particles that grow further into aggregated particles that are difficult to incorporate into teeth. A sufficient effect of promoting remineralization cannot be obtained. Therefore, conventionally, these fluorine ions and calcium ions are separated and blended into separate dentifrices, stored in a container that can contain these dentifrices separately, and these are used by discharging them from the container at the time of use. Is adopted (for example, Patent Documents 1 and 2).

  When using these techniques to discharge separate dentifrices from a container, in order to fully demonstrate the effect of promoting recalcification of teeth by fluoride ions and calcium ions, It is desirable that the dentifrice is stably discharged from the container in equal amounts.

Special Table 2000-504037 JP-A-2005-247869

  However, the present inventor has now found that a dentifrice with a low calcium ion concentration tends to be less likely to be discharged from the container over time than a dentifrice with a high calcium ion concentration. In addition, there is a possibility that a difference in the discharge properties between both dentifrices may occur due to changes in ambient temperature, and it is still difficult to discharge both dentifrices in equal amounts from the container.

  Accordingly, an object of the present invention is to store a dentifrice having a low calcium ion concentration and a dentifrice having a high calcium ion concentration in a container that can be separately stored, and to discharge these from the container at the time of use. The object of the present invention is to provide a dentifrice in a container that can discharge both dentifrices in equal amounts from the container in a stable manner without being affected by changes over time or temperature changes.

  Therefore, the present inventor has developed a dentifrice having a so-called equivalent discharge property that can stably discharge two dentifrices from the container in an equal amount without being influenced by changes over time or temperature changes. As a result of various studies, the dentifrice with a lower calcium ion concentration contains a specific amount of polyethylene glycol, while the dentifrice with a higher calcium ion concentration contains a specific polyvalent amount instead of reducing the polyethylene glycol content. It has been found that when a specific amount of alcohol is contained, a dentifrice in a container that exhibits excellent equivalent discharge properties can be obtained.

That is, the present invention has a container main body provided with two storage chambers that can be separately filled with two dentifrices, and a discharge port connected to each of the two storage chambers. In the container in which two dentifrices filled in one storage chamber are discharged from the discharge port,
The following dentifrice (A) and dentifrice (B):
(A) a dentifrice having a calcium ion concentration of less than 100 ppm and polyethylene glycol of 1 to 10% by mass; and (B) a calcium ion concentration of 1000 ppm or more and polyethylene glycol of less than 1% by mass; and A dentifrice containing a dentifrice containing 1 to 10% by mass of a polyhydric alcohol having a molecular weight of 62 to 100 is separately filled in two storage chambers.

  According to the present invention, while using two dentifrices, a dentifrice with a low calcium ion concentration and a dentifrice with a high calcium ion concentration, both dentifrices are stabilized regardless of changes over time and temperature changes. Thus, it can be discharged from the container in equal amounts. In particular, when fluorine ions are added to a dentifrice with a low calcium ion concentration, the effect of promoting remineralization of teeth can be stably exhibited without being affected by environmental changes, and tooth enamel or It is also possible to increase the amount of fluorine ions taken into the dentin.

It is a figure which shows the fluorine ion uptake | capture amount in Example 3 and Comparative Example 1. FIG.

Hereinafter, the present invention will be described in detail.
The dentifrice with a container of the present invention uses two dentifrices, a dentifrice (A) and a dentifrice (B).
The dentifrice (A) used in the present invention is a dentifrice having a calcium ion concentration of less than 100 ppm, preferably less than 50 ppm, and a lower calcium ion concentration than the dentifrice (B) described later. In this way, the dentifrice (A) contains a component that reduces the calcium ion concentration in the dentifrice (A) and instead causes a reaction when coexisting in the same dentifrice with the calcium ion, for example, fluorine ions. By storing the dentifrice (B) having a high calcium ion concentration and the dentifrice (A) in a separate storage room, the dentifrice (A) and the dentifrice (B) are mixed by being discharged from the container at the time of use. And can be reacted.

  Calcium ions are contained in the dentifrice (A) by blending the calcium ion supply compound in an amount that results in a calcium ion concentration in the above range. The calcium ion supply compound is a calcium compound that releases calcium ions in an aqueous solution. Specific examples of such calcium ion supply compounds include calcium lactate, calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcium pyrophosphate, calcium glycerophosphate, and calcium sulfate.

  When the dentifrice (A) contains fluorine ions, a fluorine ion supply compound is preferably blended. The fluorine ion supply compound is a fluorine compound that releases fluorine ions in an aqueous solution. Specific examples of such a fluorine supply compound include sodium fluoride, potassium fluoride, tin fluoride, sodium fluoride siliconate, sodium monofluorophosphate, ammonium fluoride, aluminum fluoride, and fluoride. Examples thereof include silver, hexylamine hydrofluoride, decanolamine hydrofluoride, and octadecenylamine hydrofluoride. These fluorine compounds can be used in combination of not only one but also two or more. Among these, fluorine compounds other than sodium monofluorophosphate, for example, in terms of the supply amount of fluorine ions, sodium fluoride and the like effectively increase the amount of fluoride ions taken into the tooth enamel or dentin. preferable. The content of the fluorine ion supply compound is preferably 0.02 to 0.02 in terms of fluorine atoms in the fluorine ion supply compound in the dentifrice (A) used in the present invention from the viewpoint of effectively exhibiting the effect of fluorine. It is 7 mass%, More preferably, it is 0.02-0.2 mass%. With such an amount, it becomes possible to effectively increase the amount of fluorine ions taken into the tooth enamel or dentin.

  The dentifrice (A) used in the present invention contains 1 to 10% by mass of polyethylene glycol. Polyethylene glycol has an intermolecular structure that causes a decrease in the dischargeability of the dentifrice (A) having a low calcium ion concentration with changes in time and temperature while stabilizing the components contained in the dentifrice. The formation can be moderately suppressed, and a stable equivalent discharge property can be exhibited. The content of polyethylene glycol is preferably 2 to 8% by mass, more preferably 3 to 6% by mass, in the dentifrice (A) used in the present invention, from the viewpoint of securing a stable equivalent amount ejection property. .

  The polyethylene glycol is preferably a polyethylene glycol having a number average molecular weight of 200 to 1000, more preferably 300 to 800, and still more preferably 400 to 700. When measuring the number average molecular weight of polyethylene glycol, GPC method using water / ethanol as a solvent and polystyrene as a standard is used.

  The dentifrice (A) used in the present invention may contain a polyhydric alcohol having a molecular weight of 62 to 100, but the content thereof is used in the present invention from the viewpoint of securing a stable equivalent discharge property. In dentifrice (A), it is preferable that it is less than 1 mass%, it is more preferable that it is less than 0.1 mass%, and it is still more preferable not to contain. In addition, the molecular weight of a polyhydric alcohol means a relative molecular mass.

  Specific examples of such a polyhydric alcohol having a molecular weight of 62 to 100 include glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, and 1,4-butylene glycol.

  The dentifrice (A) used in the present invention may further contain a water-soluble organic polymer other than polyethylene glycol and a polyhydric alcohol having a molecular weight of 62 to 100. Such a water-soluble organic polymer is a water-soluble organic polymer that can act as a binder or a binder.

  Specific examples of the water-soluble organic polymer other than polyethylene glycol and a polyhydric alcohol having a molecular weight of 62 to 100 include, for example, carboxymethyl cellulose or a salt thereof, hydroxyethyl cellulose or a salt thereof, hydroxypropyl cellulose or a salt thereof, poly Acrylic acid or a salt thereof, xanthan gum, carrageenan and the like can be mentioned. These may be used alone or in combination of two or more.

  Of these, carboxymethyl cellulose or a salt thereof is preferable from the viewpoint of ensuring stable discharge of an equal amount. In the case of using carboxymethyl cellulose or a salt thereof, the content thereof is a polyethylene glycol and a molecular weight of 62 to 100 in terms of moderately suppressing the formation of an intermolecular structure that causes a decrease in the dischargeability of the dentifrice (A). The total amount of the water-soluble organic polymer other than the monohydric alcohol is preferably 60% by mass or more, more preferably 80% by mass or more, and further preferably 100% by mass.

  In addition, calcium fluoride produced by the reaction between the point of securing more stable equal amount discharge and the reaction of fluorine ions released from the dentifrice (A) and calcium ions released from the dentifrice (B) Water-soluble organic polymers other than polyethylene glycol and polyhydric alcohols having a molecular weight of 62 to 100 from the viewpoint of improving the diffusibility of the fine particles and effectively increasing the amount of fluorine ions taken into the tooth enamel or dentin Among these, it is preferable to reduce the contents of xanthan gum and carrageenan. Specifically, the total content of xanthan gum and carrageenan is preferably less than 40% by mass, more preferably 20% by mass in the total amount of water-soluble organic polymer other than polyethylene glycol and polyhydric alcohol having a molecular weight of 62 to 100. More preferably, it is less than 1 mass%, More preferably, it is less than 0.1 mass%, and it is still more preferable not to contain.

  In the dentifrice (A) used in the present invention, in addition to the above-mentioned components, many other agents such as sorbitol, xylitol, pentaerythritol, pinacol, maltitol, lactitol, trehalose are used from the viewpoint of securing more stable equivalent amount ejection properties. It is preferable to reduce the content of a wetting agent such as a monohydric alcohol. Specifically, the content of the wetting agent such as polyhydric alcohol in the dentifrice (A) is preferably 5% by mass or more and less than 40% by mass, more preferably 10% by mass or more and less than 35% by mass. Yes, more preferably 20% by mass or more and less than 30% by mass.

  In addition, the dentifrice (A) used in the present invention includes a point for securing a more stable equivalent amount discharge property, and fluorine ions released from the dentifrice (A) and calcium released from the dentifrice (B). The diffusibility of calcium fluoride fine particles produced by reaction with ions is improved, and thickening silica is added from the viewpoint of effectively increasing the amount of fluorine ions taken into the tooth enamel or dentin. Also good. Specifically, the content of the thickening silica in the dentifrice (A) is preferably 1% by mass or more and less than 20% by mass, more preferably 3% by mass or more and less than 15% by mass, and still more preferably. It is 5 mass% or more and less than 10 mass%.

  The dentifrice (A) used in the present invention includes, in addition to the above components, other components within a range not inhibiting the effects of the present invention, such as phosphoric acid, citric acid, malic acid, gluconic acid, maleic acid, aspartic acid. PH adjusters such as succinic acid, glucuronic acid, fumaric acid, glutamic acid, adipic acid and their salts, hydrochloric acid, sodium hydroxide, potassium hydroxide, sodium silicate; anionic surfactants, nonionic surfactants, etc. Efficacy ingredients such as allantoin, tranexamic acid, vitamin E, vitamin C, sodium chloride, benzethonium chloride, glycyrrhetinic acid, chlorhexidine, cetylpyridinium chloride, trichlorohydroxyphenyl ether (triclosan); saccharin sodium, aspartame, thaumatin, acesulfame potassium , Stevio It may be perfumes; abrasives such as abrasive silica; id, stevia extract, para-methoxy cinnamic aldehyde, neohesperidyl dihydrochalcone sweetening agent such perillartine.

  The dentifrice (B) used in the present invention is a dentifrice having a calcium ion concentration of 1000 ppm or more, preferably 2000 ppm or more, and a higher calcium ion concentration than the dentifrice (A). Thus, when the calcium ion concentration is increased more than the dentifrice (A), a component that causes a reaction when coexisting in the same dentifrice with calcium ions in the dentifrice (A) having a low calcium ion concentration, For example, when fluorine ions are contained, the dentifrice (A) and the dentifrice (B) are stored in separate storage chambers and discharged from the container at the time of use, so that these dentifrices can be mixed and reacted. it can. It is also possible to effectively increase the amount of fluorine ions taken into the tooth enamel or dentin.

  Calcium ions are contained in the dentifrice (B) by using the same calcium ion supply compound as in the dentifrice (A) and blending it in an amount that results in a calcium ion concentration in the above range. Among the above calcium ion supply compounds, it effectively increases the calcium ion supply ability, the point of ensuring more stable equivalent discharge, and the amount of fluoride ions taken into the tooth enamel or dentin. In view of the above, calcium lactate and calcium glycerophosphate are preferable.

  As in the dentifrice (A) used in the present invention, when the calcium ion concentration is as low as less than 100 ppm, the intermolecular structure usually causes a decrease in the discharge performance of the dentifrice as time passes after the adjustment. Will progress. However, when a sufficient amount of polyethylene glycol, preferably polyethylene glycol having the number average molecular weight as described above, is contained, formation of the structure can be suppressed. Thus, since such polyethylene glycol is a high molecular weight polyhydric alcohol that maintains a liquid state at room temperature, it effectively suppresses the decrease in the discharge properties of the dentifrice over time compared to the lower molecular weight polyhydric alcohol. Can do. On the other hand, in the dentifrice (B) used in the present invention, since the calcium ion concentration is as high as 1000 ppm or more, the calcium ions inhibit the formation of an intermolecular structure that causes a decrease in the dischargeability of the dentifrice, and the structure formation Is suppressed. Accordingly, in the dentifrice (B), it is generated between the dentifrice (A) and the dentifrice (B) by containing 1 to 10% by mass of a polyhydric alcohol having a molecular weight of 62 to 100 instead of polyethylene glycol. It is possible to reduce the difference in dischargeability variation with the passage of time and temperature, and the discharge balance between the dentifrice (A) and the dentifrice (B) that has been immediately after preparation is It is held without being affected by changes in temperature and temperature, and can exhibit a stable equivalent discharge performance.

  The content of polyethylene glycol in the dentifrice (B) used in the present invention is preferably less than 1% by mass, more preferably less than 0.1% by mass, from the viewpoint of ensuring stable equivalent discharge. More preferably, it is less than 0.01% by mass, and further preferably does not contain polyethylene glycol. In addition, as a polyethylene glycol contained in a dentifrice (B), the thing similar to a dentifrice (A) is mentioned.

  The dentifrice (B) used in the present invention contains 1 to 10% by mass of a polyhydric alcohol having a molecular weight of 62 to 100. The content of the polyhydric alcohol having a molecular weight of 62 to 100 is preferably 2 to 8% by mass, more preferably 3 in the dentifrice (B) used in the present invention, from the viewpoint of securing a stable equivalent discharge property. -6 mass%. With such an amount, when fluoride ions are contained in the dentifrice (A), these polyhydric alcohols are released from the fluoride ions released from the dentifrice (A) and from the dentifrice (B). Contributes to stabilizing calcium fluoride fine particles produced by reaction with calcium ions, and promotes the adsorption of calcium fluoride fine particles to the tooth surface. As a result, fluoride ions on tooth enamel and dentin It is thought that the amount of uptake increases.

  Specific examples of such a polyhydric alcohol having a molecular weight of 62 to 100 include glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, and 1,4-butylene glycol. Among these, in dentifrice (B) with high calcium ion concentration, it is possible to ensure more stable equivalent discharge, and to effectively increase the amount of fluoride ions taken into tooth enamel or dentin. Of these, propylene glycol is preferred.

  Similarly to the dentifrice (A), the dentifrice (B) used in the present invention may contain a water-soluble organic polymer other than polyethylene glycol and a polyhydric alcohol having a molecular weight of 62 to 100. Examples of such a water-soluble organic polymer include those similar to those used in the dentifrice (A), and carboxymethyl cellulose or a salt thereof is preferable from the viewpoint of ensuring stable equivalent discharge. The preferable content is also the same. Moreover, it is the same that it is preferable to reduce the content of xanthan gum and carrageenan, and the preferable total content is also the same.

  In addition, the dentifrice (B) used in the present invention includes sorbitol, xylitol, pentaerythritol, pinacol, multi-components other than the above-mentioned components from the viewpoint of securing a more stable equivalent amount ejection property as in the dentifrice (A). It is preferable to reduce the content of wetting agents such as polyhydric alcohols such as tall, lactitol and trehalose. Specifically, the content of the wetting agent such as polyhydric alcohol in the dentifrice (B) is preferably 5% by mass or more and less than 40% by mass, more preferably 10% by mass or more and less than 35% by mass, More preferably, it is 15 mass% or more and less than 30 mass%.

  The dentifrice (B) used in the present invention may contain thickening silica as in the dentifrice (A). The content of the thickening silica is the same as that for the dentifrice (A), from the viewpoint of ensuring stable equivalent discharge, and from the fluorine ions and dentifrice (B) released from the dentifrice (A). Dentifrice from the point that diffusibility of calcium fluoride fine particles produced by reaction with released calcium ions is improved, and the amount of fluorine ions taken into tooth enamel or dentin is effectively increased. In (B), it is preferably 1% by mass or more and less than 20% by mass, more preferably 3% by mass or more and less than 15% by mass, and further preferably 5% by mass or more and less than 10% by mass.

  To the dentifrice (B) used by this invention, you may mix | blend the other component similar to a dentifrice (A) in the range which does not inhibit the effect of this invention other than the said component.

  When the dentifrice (A) used in the present invention contains fluorine ions, from the viewpoint of increasing the amount of fluorine ions taken into the enamel or dentin of the teeth, other than polyethylene glycol and polyhydric alcohols having a molecular weight of 62 to 100 As the component, it is preferable to use a combination of the above carboxymethylcellulose or a salt thereof and thickening silica, and more preferably, as a water-soluble organic polymer other than polyethylene glycol and a polyhydric alcohol having a molecular weight of 62 to 100, carboxymethylcellulose or It is preferable to use only the salt in combination with thickening silica. The reason for this is not clear, but when the fluoride fluoride particles released from the dentifrice (A) and the calcium ions released from the dentifrice (B) react to produce calcium fluoride particles, It is considered that the diffusibility is enhanced and the contact amount of the calcium fluoride fine particles to the teeth increases, and the amount of fluoride ions taken into the tooth enamel and dentin increases.

  The dentifrice with a container of the present invention is a container having the above-mentioned dentifrice (A) and dentifrice (B) in a container body having two storage chambers and a discharge port connected to each of the two storage chambers. Manufactured by filling. These two dentifrices are filled separately in the two storage chambers of the container. By pressing the container body of the container, the dentifrice (A) and the dentifrice (B) filled in the two storage chambers are discharged from the discharge port in, for example, two layers. Specific examples of such containers include squeeze containers, preferably tube containers.

  The two storage chambers only have to be connected to one discharge port at one end, and may be provided in the container so as to be separated from each other so that the filled contents are not mixed. For example, it may be in the form of a bag or a small container that can be inserted into the container, or may be a form in which separate containers are joined at the mouth portion provided with the discharge port. In particular, by pressing the container main body, the two storage chambers of the container main body can be easily discharged in equal amounts without depending on the pressing force. It is preferable to have a form divided by cylindrical partition walls provided concentrically on the cross section.

  EXAMPLES Hereinafter, although this invention is demonstrated concretely based on an Example, this invention is not limited to these Examples.

[Examples 1 to 4, Comparative Examples 1 to 5]
Each dentifrice (A) and dentifrice (B) were prepared according to the formulation shown in Tables 1-2. The container was provided with the obtained dentifrice (A) and dentifrice (B) using a container in which two storage chambers were divided by a cylindrical partition wall provided concentrically on the cross section of the container body. Two storage chambers were filled separately, and an evaluation test was performed according to the following method. The results are shown in Table 3.

[Evaluation test of equivalent discharge]
After storing according to the storage days and temperatures shown in tests [1] to [4] in Table 3, the container body was pressed to discharge the dentifrice (A) and the dentifrice (B) from the discharge port by about 1 cm. Subsequently, each mass of the discharged dentifrice (A) and dentifrice (B) was measured, and the ratio was calculated | required. This test was performed three times and the average value was obtained. Test [4] is a test that was stored at 40 ° C. for 30 days, then stored at 25 ° C. for 1 day, and performed at room temperature (25 ° C.).

  According to Tables 1-3, Examples 1-4 are mass ratios ((A) of dentifrice (A) and dentifrice (B) discharged from the container in any test [1]-[4]. : (B)) is in the range of 6: 4 to 4: 6, and it can be seen that stable equivalent discharge performance is exhibited regardless of variations in time and temperature.

  On the other hand, Comparative Examples 1 to 3 in which both the dentifrice (A) and the dentifrice (B) contain 1 to 10% by mass of polyethylene glycol have a stable equivalent discharge performance affected by variations in time and temperature. It can be seen that it cannot be retained. Further, Comparative Example 4 in which neither the dentifrice (A) nor the dentifrice (B) contains polyethylene glycol, and Comparative Example 5 in which the dentifrice (B) contains 1 to 10% by mass of polyethylene glycol. Even in this case, it is apparent that the stable ejection ability cannot be maintained.

[Evaluation test for fluoride ion uptake]
Using the dentifrice prepared in Example 3 and Comparative Example 1, each sample of a total of 5 g of the dentifrice (A) and dentifrice (B) discharged by pressing the container body was diluted twice with purified water. Then, 10 mm × 10 mm × 2 mm of HAP pellet (APP-100 HOYA) was immersed in this for 2 minutes, and then the dentifrice was removed with ion-exchanged water to dry the pellet. Extraction of fluoride ions from the dried pellets with 1N hydrochloric acid for 30 seconds, using a fluorine ion electrode (ionplus-Fluoride (ORION)) and an ion analyzer (Expandable ionAnalyzer EA 940 (ORION)) The amount of fluorine adsorbed on the HAP pellets (μg / cm ² ) was quantified.
The results are shown in FIG.

  From the results of FIG. 1, it was confirmed that Example 3 having a good equidistant ejection performance showed a higher fluorine uptake amount than Comparative Example 1.

Claims (5)

It has a container main body with two storage chambers that can be filled with two dentifrices separately, and a discharge port connected to each of the two storage chambers, and is filled into the two storage chambers by pressing the container main body. In a container in which two dentifrices using a calcium ion supply compound selected from calcium lactate and calcium glycerophosphate are discharged from the discharge port,
The following dentifrice (A) and dentifrice (B):
(A) The calcium ion concentration is less than 100 ppm , the polyethylene glycol is 1 to 10% by mass , the thickening silica is 1 to 20% by mass, and the polyhydric alcohol having a molecular weight of 62 to 100 is 0.1%. less than wt%, and the multivalent water-soluble organic polymer total amount of non-alcohol polyethylene glycol and molecular weight 62-100, carboxymethylcellulose or der Ru dentifrice content not less than 60 wt% of a salt thereof, and (B) calcium ion concentration is not less 1000ppm or more, polyethylene glycol is less than 1 wt%, thickening silica is 20% by weight or less than 1 wt%, propylene glycol Ri 1 to 10% by mass, and In the total amount of water-soluble organic polymer other than polyethylene glycol and polyhydric alcohol having a molecular weight of 62-100 Of carboxymethylcellulose or packaged dentifrices content is filled separately Ru der least 60 wt% dentifrice two accommodating chambers of a salt thereof. The dentifrice in a container according to claim 1, wherein the dentifrice (A) contains 0.02 to 0.7 mass% of a fluorine ion supply compound in terms of fluorine atoms. The dentifrice with a container according to claim 1 or 2, wherein the total content of carrageenan and xanthan gum in the total amount of water-soluble organic polymer other than polyethylene glycol and a polyhydric alcohol having a molecular weight of 62 to 100 is less than 20% by mass.   The number average molecular weight of polyethylene glycol is 200-1000, The dentifrice with a container of any one of Claims 1-3. The dentifrice with a container according to claim 1, wherein the two storage chambers are divided by a cylindrical partition wall provided concentrically on a transverse section of the container body.