JP5844541B2 - Needleless syringe - Google Patents

Description

  The present invention relates to a needleless syringe that injects a substance to be injected into an injection target region without using an injection needle.

  In a needleless syringe that performs injection without going through an injection needle, a configuration may be employed in which an injection component is ejected by applying pressure to an injection solution with a pressurized gas or a spring. For example, Patent Document 1 specifically discloses a configuration of a nozzle through which a pressurized injection solution is injected to an injection target. In the nozzle disclosed in Patent Document 1, a flow path for injecting an injection solution is formed around a central hole through which a pressurized injection solution flows. Specifically, an injection flow path is formed so as to be parallel to the axial direction of the central hole via an intake port formed by sitting radially outward from the central hole. In addition, the downstream plug member that sealed the injection solution before injection is accommodated in a recess provided on the downstream side of the central hole so as not to hinder the flow of injection solution into the flow path at the time of injection. The

JP-T-2006-523484

  In the case of a needleless syringe, in order to deliver the injection solution to the inside of the injection target, the energy required for moving the injection solution and the energy for penetrating the surface layer of the injection target must be accurately transmitted to the injection solution. Therefore, unlike a syringe having a needle, instantaneous pressurization of an injection solution may be performed. When such instantaneous pressurization is performed, the more complicated the flow path in the syringe formed for injection of the injection liquid, the more easily the injection liquid remains in the flow path.

  For example, in the needleless syringe shown in the above-mentioned Patent Document 1, when the injection solution is pressurized, the injection solution that has advanced in the axial direction of the storage chamber flows into the flow path via the intake port, so that the injection target object is obtained. Will be injected. In this case, the injection solution is finally ejected in the same direction as the pressurizing direction (the axial direction of the storage chamber), but the intake port passes through the intake port in the process up to that time. Therefore, since the flow of the injection solution is complicated, the injection solution is likely to remain in the syringe after the injection. Depending on the components of the injection solution, the cost is not low enough to ignore the remaining amount, and it is not preferable that the injection solution remains in the syringe from the viewpoint of injecting an appropriate amount of the injection solution for the injection target.

  In view of the above problems, an object of the present invention is to provide a needleless syringe that can suppress the amount of an injection solution remaining in a syringe after injection as much as possible.

  In order to solve the above-described problems, the present invention provides a nozzle flow path for forming an injection flow to a region to be injected in a configuration of a flow path portion of a needleless syringe through which an injection target substance pressurized for injection flows. The introduction port is opened directly in the passage through which the pressurized injection target substance flows, and the plug portion that sealed the injection target substance before pressurization is arranged so as not to interfere with the introduction port of the nozzle flow path. It was decided. With this configuration, the injection target substance can be smoothly injected into the injection target region through the nozzle flow path while maintaining good injection of the injection target substance by the pressurization as usual, and thus the injection target substance remains in the syringe. The amount can be suppressed as much as possible.

  Specifically, a syringe for injecting an injection target substance into an injection target region without going through an injection needle, the sealing part for sealing the injection target substance, and the injection target substance sealed in the sealing part A pressurizing unit that pressurizes the flow path, and a flow path unit that defines a flow path so that the injection target substance pressurized by the pressurizing unit is ejected to the injection target region. The enclosing portion stores the injection target substance in a storage space formed by being sandwiched between the upstream plug member and the downstream plug member, and the upstream plug member applies the pressure applied by the pressurizing unit. It arrange | positions so that it may convey to this injection target substance in a storage space. In addition, the flow path section includes an accommodating section that accommodates the downstream plug member moved together with the injection target substance by the pressurization when the pressurization section is pressurized, on the downstream side in the moving direction. A passage connecting an initial position where the downstream side plug member is positioned before pressurization by the pressurizing unit and an accommodation position of the downstream side plug member by the accommodating unit, and the downstream side plug by the pressurization At least one nozzle flow path having a moving passage through which a member moves and an introduction port opened to communicate with the moving passage and having an injection port for the injection target substance into the injection target region; In the state where the side plug member is housed in the housing portion, the needle-free device has a nozzle passage through which the injection target substance flows through the nozzle passage and the moving passage through the introduction port. A syringe is formed.

  In the needleless syringe according to the present invention, before injection, the injection target substance is stored in the storage space defined by the upstream and downstream plug members. On the other hand, pressure is applied. Thereby, the injection target substance moves in the syringe together with the both plug members, and is ejected to the injection target region through the flow path defined by the flow path portion. This injection target substance contains a component expected to have an effect inside the injection target region, and the pressure applied as described above is a driving source at the time of injection. Therefore, if injection by pressurization is possible, the physical state of the injectable substance in the needle-free syringe and the specific physical substance of the injectable substance such as liquid, gel-like fluid, powder, granular solid, etc. The form is not asked.

  For example, the injection target substance is a liquid, and even if it is a solid, it may be a gel-like solid as long as fluidity enabling injection is ensured. The injection target substance includes, for example, a component to be sent to the injection target region of the living body, and the component may exist in a dissolved state inside the injection target substance, or the component is simply dissolved without being dissolved. It may be in a mixed state. For example, as ingredients to be delivered, there are vaccines for antibody enhancement, proteins for cosmetics, cultured cells for hair regeneration, etc., so that these can be injected into fluids such as liquids and gels. By inclusion, a substance for injection is formed.

  Various pressurization sources can be used as the pressurization source for the injection target substance as long as injection by pressurization is possible. For example, those using elastic force by springs, those using pressurized gas, those using explosive combustion, those using electrical actuators (motors, piezo elements, etc.) for pressurization And as a pressure source.

  The injection target substance thus pressurized is injected into the target region through the flow path defined by the flow path section, and in detail about the flow path section, A movement path and a nozzle channel are included. The accommodating portion is disposed on the downstream side in the moving direction in order to accommodate the downstream plug member that has moved in the syringe together with the injection target substance by pressurization. The accommodating portion accommodates the downstream plug member after pressurization so as not to prevent the injection target substance moving together with the downstream plug member from flowing into the nozzle flow path for injection. Therefore, as long as the object is achieved, the shape and size of the housing portion are not limited, but the shape and size in consideration of the smooth housing in the housing portion and the functional impact of the syringe of the present invention after housing The size is preferred.

  Here, the needleless syringe according to the present invention is configured such that the moving passage is interposed between the initial position of the downstream side plug member before pressurization and the storage position by the storage portion. That is, the downstream side plug member moves in the moving passage by the applied pressure and is accommodated in the accommodating portion. In addition, since the injection target substance and the downstream plug member are moved by the driving force through the upstream plug member directly pressurized by the pressurizing unit, the upstream plug member also moves in the movement path. Here, the needleless syringe employs a configuration in which the introduction port of the nozzle channel communicates with the movement passage, that is, the introduction port opens directly in the movement passage. And in the state in which the downstream side plug member was accommodated in the accommodating part, the distribution | circulation of the injection target substance from the movement channel | path through the inlet to the nozzle flow path will be ensured. That is, the inlet of the nozzle channel is not blocked by the downstream plug member even if the downstream plug member is accommodated in the accommodating portion, and the injection target substance flows directly into the nozzle channel from the movement channel. It becomes possible.

  When the downstream plug member is accommodated in the accommodating portion, the upstream plug member positioned further upstream approaches the downstream plug member by the applied pressure. At this time, the injection target substance sandwiched between the plug members flows into the nozzle flow path through the introduction port in which the injection target substance is ensured to flow between the downstream plug member and the upstream plug member. The target substance to be injected is reduced, and eventually the plug members come into contact with each other. The injection target substance that has flowed into the nozzle channel is ejected from the ejection port of the nozzle channel to the injection target area.

  In the needleless syringe configured as described above, the downstream plug member is quickly accommodated in the accommodating portion by the pressurization of the pressurizing portion, and in the accommodated state, the downstream plug member is directly in the moving passage. A configuration that does not hinder the flow of the injection target substance into the opened nozzle channel is employed. Therefore, the pressure applied by the pressurizing part is efficiently transmitted to the injection target substance, and the injection target substance can smoothly flow into the nozzle flow path. In addition, since the nozzle channel directly opens in the moving passage, the nozzle channel exists between the plug members toward the state where the upstream plug member contacts the downstream plug member accommodated in the accommodating portion. The injection target substance flows into the nozzle flow path very smoothly, and the amount of the injection target substance remaining in the syringe after injection can be suppressed as much as possible.

  Here, in the needleless syringe, the injection direction of the injection target substance defined by the introduction port and the injection port in the nozzle flow path is determined by the pressurization of the pressurizing unit. You may set so that it may become non-parallel with respect to the said moving direction which moves with a side plug member. By comprising in this way, the injection direction of the injection target substance in a nozzle flow path can be set flexibly. More preferably, the injection target substance flows linearly from the introduction port to the injection port. As a result, it becomes possible to efficiently inject the injection target substance circulated from the moving passage directly into the nozzle flow path into the injection target region, contributing to the suppression of the remaining amount of the injection target substance in the syringe. it can.

  More specifically, the needleless syringe further includes a syringe body including the enclosing part, the pressurizing part, and the flow path part, and the moving direction is from the rear end side to the front end side of the syringe body. The injection port of the nozzle channel may be configured to open to the side of the syringe body. That is, pressurization by the pressurizing unit is performed in the distal direction of the syringe body, but the injection direction of the injection target substance is different from the pressurization direction, and a configuration that is on the side of the syringe body can also be adopted. According to the said structure, since it becomes possible to form the length of a nozzle flow path comparatively short, it can contribute to suppression of remaining amount more.

  Here, in the needleless syringe up to the above, the flow path section has a nozzle flow path having an introduction port opened to communicate with the moving passage and an injection port for the injection target substance to the injection target region. Wherein the injection target substance moves together with the downstream plug member by pressurization of the pressurizing section, along the moving direction, upstream of the nozzle flow path and separately from the nozzle flow path. You may further have the other nozzle channel provided. Thus, by providing another nozzle flow path, it becomes possible to smoothly discharge the injection target substance from the moving passage.

  Further, in the needleless syringe described above, in the state where the downstream side plug member is accommodated in the accommodation part, a peripheral portion of a contact surface of the downstream side plug member with the upstream side plug member, the upstream side plug member The nozzle channel and the moving passage are formed by a chamfered portion provided on at least one of the peripheral part of the contact surface of the downstream plug member or the peripheral part of the inlet of the nozzle channel. The injection target substance may be distributed. That is, these chamfered portions ensure the flow of the injection target substance through the inlet of the nozzle channel. That is, even when the downstream side plug member and the upstream side plug member are in contact with each other, a space through which the injection target substance flows toward the introduction port is formed. These chamfered portions may be provided at a plurality of locations among the downstream side plug member, the upstream side plug member, and the inlet of the nozzle channel, but the chamfered portion remains there when the space occupied by the chamfered portion becomes large. Since there is a possibility that the amount of the injection target substance that can be increased, it is preferable that the arrangement of the chamfered portions is as small as possible from the viewpoint of suppressing the remaining amount.

  Here, regarding the formation of the nozzle flow path, the nozzle member having the nozzle flow path with respect to the flow path portion may be formed in a detachable manner. That is, the flow path portion further includes a nozzle member including the nozzle flow path, and the inlet of the nozzle flow path is positioned on the movement path side so that the inner wall surface of the movement path You may comprise so that a nozzle member may be engage | inserted. With this configuration, it is possible to replace only the nozzle member having an injection port that can come into contact with the injection target region, and to provide the syringe itself for new injection applications while leaving the other syringe configurations as they are.

  In addition, when fitting a nozzle member in the inner wall surface of a movement channel | path, when the said nozzle member will be in the state protruded in the movement channel | path, there exists a possibility of preventing the movement of a downstream plug member or an upstream plug member. Therefore, in a state where the nozzle member is fitted into the inner wall surface of the moving passage, the inlet of the nozzle channel may be configured to be located in a recess that is recessed from the inner wall surface of the moving passage. Thereby, it becomes possible to avoid the interference with the downstream side plug member etc. by the protrusion of a nozzle member.

  On the other hand, when the nozzle member is fitted in the moving passage, a stepped portion, a tapered portion or the like is formed in the syringe body and the nozzle member so that the nozzle member does not jump out due to pressure. Therefore, the nozzle member is attached from the flow path portion (moving passage) side. Although depending on the shape of the moving passage, for example, when the moving passage is formed in a cylindrical shape, the operation of inserting the nozzle member into the passage may not be easy. The moving passage is a place where the downstream plug member and the like should move smoothly, and is also a place through which the injection target substance sandwiched between the plug members flows into the nozzle channel. For this reason, it is preferable that the injection target substance has a shape that does not diffuse unnecessarily. In that case, there is a possibility that the nozzle member cannot be easily fitted. Therefore, in the needleless syringe up to the above, it is a member that includes the moving passage and the accommodating portion and holds the nozzle member in a detachable manner, and is fixed to the main body of the syringe while holding the nozzle member In addition, a configuration may be adopted that further includes a holding member that guides the injection target substance pressurized by the pressurizing unit to the nozzle flow path through the moving passage. The holding member is formed by combining a plurality of divided elements, and the nozzle member can be attached to and detached from a part of the inner wall surface of the moving path included in the divided one element. Formed as follows. By forming the moving passage by assembling the dividing elements, the nozzle member can be fitted into the divided elements before the assembly, and therefore the nozzle member cannot be easily fitted as described above. The situation can be eliminated.

  Here, in the needleless syringe described above, the flow path portion may further include a communication hole that communicates the storage portion with the outside of the syringe. By providing such a communication hole, the air in the housing portion when the downstream side plug member is housed in the housing portion can be discharged out of the syringe, so that the downstream side plug member can be smoothly accommodated in the housing portion. Efficient injection of the injection target substance can be realized.

  In the needleless syringe described above, the inner diameter of the accommodation space and the inner diameter of the movement passage are substantially the same, and the inner diameters of the accommodation space, the movement passage, and the accommodation portion are the movements. It may be substantially constant over the direction. By forming the accommodation space, the movement path, and the accommodation portion in this manner, the amount of the injection target substance that can remain in the interior can be suppressed.

  It becomes possible to provide a needleless syringe that can suppress the amount of the injection solution remaining in the syringe after injection as much as possible.

It is a figure which shows schematically the state before injection in the needleless syringe which concerns on this invention. It is a figure which shows roughly the state at the time of completion of injection in the needleless syringe which concerns on this invention. It is a figure which shows a mode that the nozzle member which has a nozzle flow path is mounted | worn with a nozzle holder in the needleless syringe which concerns on this invention. It is an enlarged view of the structure of the nozzle flow path vicinity of the needleless syringe shown to FIG. 1B. FIG. 3 is a first view showing a state where a nozzle member is mounted on a nozzle holder in FIG. 2. FIG. 3 is a second view showing a state where the nozzle member is mounted on the nozzle holder in FIG. 2. It is a figure which shows the 2nd structure of the nozzle holder of the needleless syringe which concerns on this invention. It is a 1st figure which shows the mode of attachment to the syringe main body side of the nozzle holder in the needleless syringe which concerns on this invention. It is a 2nd figure which shows the mode of the attachment to the syringe main body side of the nozzle holder in the needleless syringe which concerns on this invention. In the needleless syringe which concerns on this invention, it is a figure which shows the condition of the downstream plug member vicinity after pressurizing an injection solution.

  Hereinafter, a needleless syringe 20 (hereinafter simply referred to as “syringe 20”) according to an embodiment of the present invention will be described with reference to the drawings. The configuration of the following embodiment is an exemplification, and the present invention is not limited to the configuration of this embodiment.

  Here, FIGS. 1A and 1B are cross-sectional views along the axial direction of the syringe 20, and more specifically, FIG. 1A is a diagram showing the state inside the syringe 20 before injection, and FIG. 1B is the syringe when injection is completed. FIG. Therefore, in the state shown in FIG. 1A, the injection solution is sealed in the syringe 20, while in the state shown in FIG. 1B, the sealed injection solution is an injection object outside the syringe 20. Is in a state of being injected. In the following description of the present application, the injection target substances injected into the injection target by the syringe 20 are collectively referred to as “injection solution”. However, this is not intended to limit the content or form of the injected substance. As the injection target substance, for example, the component to be delivered to the skin structure of the living body may or may not be dissolved, and the injection target substance is also pressurized from the nozzle channel 3 described later by pressurization. As long as it can be injected to the body, its specific form is not limited, and various forms such as liquid and gel can be adopted.

  The syringe 20 has a syringe body 1, and a central portion of the syringe body 1 is provided with a through hole 9 extending in the axial direction and having a constant diameter along the axial direction. . One end of the through hole 9 reaches the pressure generating unit 6 (pressurizing unit) side that pressurizes the injection solution sealed in the syringe 20 as will be described later, and the other end is the injection target. It reaches the nozzle holder 2 (holding member: hereinafter simply referred to as “holder 2”) in which the nozzle flow path 3 serving as the injection path of the injection solution to the object is formed.

  Here, the sealed state of the injection solution in the through hole 9 will be described. As shown in FIG. 1A, in the state before injection, the injection solution is contained in the through hole 9 and is sandwiched between the upstream side plug member 8 and another downstream side plug member 10 (enclosure part). It is enclosed inside. Note that the definitions of “upstream” and “downstream” in the present application are determined based on the flow of an injection solution generated by pressurization during injection. Therefore, the upstream side plug member 8, the downstream side plug member 10, and the through hole 9 form a sealed portion of the syringe according to the present invention. Further, in order to transmit the driving force for injection of the injection solution generated in the pressure generating unit 6 to the injection solution thus sealed, the upstream side through hole 9 of the upstream side plug member 8 is made of metal. A piston 7 made of metal is arranged. One end of the piston 7 is in contact with the upstream side plug member 8, and the other end is disposed in the through hole 9 so that the driving force (pressure) by the pressure generating unit 6 can be received. In this way, the driving force from the pressure generating unit 6 can be transmitted to the injection solution through the piston 7, and the injection solution, together with the upstream side plug member 8 and the downstream side plug member 10, passes through the through hole 9. It flows downstream and is sent to the holder 2 side described later. In order to realize the above-described configuration, the upstream side plug member 8 and the downstream side plug member 10 are provided with an injection solution so that the injection solution does not leak when the injection solution is sealed and the driving force is transmitted from the piston 7. Fluorine rubber stopper (disclosed in JP-A-2009-61343) or a surface of a rubber base material coated with fluorine-based resin (JP-A H9- 59396) can be suitably used.

  Here, the pressure generator 6 will be described. As one specific embodiment, a pressure generation form using the combustion of explosives can be employed. For example, an initiator that burns an igniting agent when electrically energized can be used. As the igniting agent, preferably, an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), an explosive containing titanium and potassium perchlorate (TiPP), aluminum, Gunpowder containing potassium perchlorate (APP), Gunpowder containing aluminum and bismuth oxide (ABO), Gunpowder containing aluminum and molybdenum oxide (AMO), Gunpowder containing aluminum and copper oxide (ACO), Aluminum and iron oxide included Examples include explosives (AFO) or explosives composed of a plurality of combinations of these explosives. These explosives generate high-temperature and high-pressure plasma at the time of combustion immediately after ignition. However, when the combustion product is condensed at a normal temperature and does not contain a gas component, the generated pressure rapidly decreases. As long as appropriate injection is possible, other explosives may be used as igniting agents.

  The combustion product generated by the combustion of the igniting agent in the initiator is transferred to a separately provided gas generating agent, so that the driving force transmitted from the pressure generating unit 6 to the piston 7 is made more suitable. Can do. As an example of the gas generating agent, a single base smokeless gunpowder composed of 98% by mass of nitrocellulose, 0.8% by mass of diphenylamine and 1.2% by mass of potassium sulfate can be mentioned. It is also possible to use various gas generating agents that are used in gas generators for airbags and gas generators for seat belt pretensioners. These gas generating agents differ from the above-mentioned igniting agents, and the predetermined gas generated during combustion contains a gas component even at room temperature, so that a relatively long combustion time can be ensured, and is necessary for injection of the injection solution. Sufficient driving force can be generated as the pressure generator 6.

  Here, a holder 2 having a nozzle flow path 3 for injecting an injection solution is provided on the distal end side (right side in FIG. 1A) of the syringe 20. As shown in FIG. 2, the nozzle flow path 3 is formed in the syringe 1 by mounting a nozzle member 31 formed separately from the holder 2 on the holder 2. When the member 31 is removed from the holder 2 and replaced with a new nozzle member 31, the syringe itself is used for the next injection. That is, in the syringe 20, the nozzle member 31 having the nozzle flow path 3 is a so-called disposable type nozzle, and can be replaced with a new nozzle each time an injection solution is injected, or for an injection site or application. Therefore, the nozzle member 31 is detachably held with respect to the holder 2 so that the nozzle member 31 can be replaced. Further, in order to enable such a detachment of the nozzle member 31, the holder 2 is also detachable from the syringe body 1, and details thereof will be described later.

  Next, the detailed structure of the holder 2 will be described. When the holder 2 is attached to the syringe body 1 and the upstream side plug member 8 is pressurized by the pressure generator 6, the recess 5 in which the downstream side plug member 10 that moves together with the injection solution is finally accommodated, It is provided in the holder 2. Specifically, in a state where the holder 2 is attached to the syringe body 1, a concave portion (accommodating portion) 5 is provided on the downstream side in the direction in which the downstream side plug member 10 moves due to pressurization of the pressure generating portion 6. 5 has substantially the same diameter as the downstream plug member 10 and a depth substantially equal to the length of the downstream plug member 10. And between the initial position of the downstream plug member 10 before pressurization, ie, the position of the downstream plug member 10 shown in FIG. As described above, the moving passage 4 and the recessed portion 5 are arranged on the axis of the through hole 9, so that the downstream side plug member 10 can smoothly reach the recessed portion 5 through the moving passage 4 from the initial position. It is possible. Further, the inner diameters of the through hole 9 and the moving passage 4 are substantially the same in the axial direction of the syringe 20, and the inner diameters of the through hole 9, the moving path 4 and the recess 5 are formed to be substantially constant.

  By being configured in this way, when the pressure is applied to the piston 7 by the pressure generating portion 6 and the injection solution moves to the distal end side of the syringe 20 together with the upstream side plug member 8 and the downstream side plug member 10, the downstream side plug member. 10 is accommodated in the recess 5. When the downstream side plug member 10 is accommodated in the recess 5, the sealed injection solution is released, and the injection solution flows through the moving passage 4 to the nozzle flow with the pressurization from the upstream side plug member 8 to the injection solution. It will be ejected from the path 3 to the injection target outside the syringe.

  Here, as shown in FIG. 3, the holder 2 according to the present embodiment has a pressing direction of the injection solution, in other words, a moving direction in which the injection solution first moves due to the pressurization of the pressure generating unit 6. The three nozzle flow paths 3 are formed in a line along the direction toward the tip of the syringe 20. In any of the nozzle flow paths 3, the introduction port is directly opened to the moving passage 4 and the injection port is opened to the side of the syringe 20. The most downstream nozzle flow path 3 (hereinafter, “most downstream” The nozzle channel 3 ”) is formed to have a function different from that of the two nozzle channels 3 on the upstream side (hereinafter referred to as“ other nozzle channels 3 ”).

  The opening of the most downstream nozzle flow path 3 is positioned relative to the downstream plug member 10 so that the downstream plug member 10 is not blocked by the downstream plug member 10 when the downstream plug member 10 is accommodated in the recess 5. It has been decided. Further, a chamfered portion 10 a is formed at the peripheral portion of the surface of the downstream side plug member 10 that faces the upstream side plug member 8. A state in which the downstream plug member 10 is accommodated in the recess 5 by ensuring that the injection solution enters the substantially annular space formed by the peripheral edge portion of the downstream plug member 10 and the moving passage 4 by the chamfered portion 10a. However, the flow state of the injection solution through the inlet of the most downstream nozzle flow path 3 is maintained. Further, when the downstream side plug member 10 is accommodated in the recess 5, the further pressurized upstream side plug member 8 comes close to the downstream side plug member 10 and finally comes into contact. As a result, the injection solution sealed between the downstream side plug member 10 and the upstream side plug member 8 flows into the three nozzle flow paths 3 opened there through the moving passage 4. Immediately before the upstream side plug member 8 contacts the downstream side plug member 10, the inlets of the other nozzle flow paths 3 except the most downstream nozzle flow path 3 are blocked by the upstream side plug member 8. End up. However, even when the upstream plug member 8 is in contact with the downstream plug member 10, the chamfered portion 10a causes the opening of the most downstream nozzle channel 3 to be connected to the downstream plug member 10 as well. 8 is not closed, and the injection solution is kept in a state where it can flow into the most downstream nozzle passage through the inlet.

  In this way, it has an introduction port that opens directly to the moving passage 4, and it is always between the time when the downstream side plug member 10 is accommodated in the recess 5 and the time when the upstream side plug member 8 contacts the downstream side plug member 10. By having the most downstream nozzle flow path 3 held so that the injection solution can flow from the movement path 4 into the nozzle flow path through the introduction port, the inside of the syringe 20, particularly the movement path 4. It is possible to suppress the remaining amount of the injection solution inside. In addition, the injection port of the most downstream nozzle channel 3 opens directly into the moving passage 4, and the injection direction of the injection solution defined by the introduction port and the injection port (in this embodiment, from the inside of the syringe to the side) The direction of heading is not parallel to the initial moving direction of the injection solution by pressurization (in this embodiment, the direction toward the tip of the syringe 20) (in FIG. 3, the injection direction is perpendicular to the moving direction). In other words, since the injection direction and the movement direction are different, the injection solution drawn into the nozzle flow path from the introduction port is injected outside through a relatively short path. It becomes composition. For this reason, it is possible to eliminate the formation of a space (liquid reservoir space) in which the injection solution easily accumulates in the syringe. As a result, an efficient injection of injection solution can be realized. In addition, as shown in FIG. 3, the most downstream nozzle flow path 3 moves with the suppression of the formation of the liquid pool space because the injection solution flows through the inlet even when the injection is completed. The remaining amount of the injection solution in the passage 4 can be suppressed as much as possible.

  Moreover, also in the other nozzle flow paths 3 excluding the most downstream nozzle flow path 3 among the three nozzle flow paths 3, those inlets are directly open to the movement path 4. Injection of the injection solution to the injection target is realized while eliminating the formation of the liquid pool space. However, as shown in FIG. 3, the inlet of the other nozzle channel 3 is directly closed by the upstream side plug member 8 or positioned upstream of the upstream side plug member 8 when the injection is completed. Therefore, unlike the most downstream nozzle flow path 3, it does not contribute to the discharge of the injection solution until the last point of completion of the injection. However, by providing at least one most downstream nozzle flow path 3 as described above, injection solution remaining in the syringe 20 can be suppressed. From this point of view, the syringe 20 may be configured to include a plurality of nozzle channels having a discharge function similar to that of the most downstream nozzle channel 3.

  Further, in the above-described embodiment, the flow of the injection solution into the most downstream nozzle flow path 3 is held by the chamfered portion 10 a of the downstream side plug member 10, but instead, the downstream side of the upstream side plug member 8. A chamfered portion may be provided at the peripheral edge of the surface facing the side plug member 10, and the flow into the most downstream nozzle flow path 3 may be held by the chamfered portion, and the inlet of the most downstream nozzle flow path 3 may be maintained. A chamfered portion may be provided at the peripheral edge, and the flow into the most downstream nozzle flow path 3 may be held by the chamfered portion. Further, these chamfered portions may be appropriately combined to hold the flow into the most downstream nozzle flow path 3.

  In the above embodiment, the holder 2 has three nozzle channels arranged in a line along the moving direction of the injection solution. However, the present invention is not limited to this and may be arranged in a plurality of lines. However, as the number of nozzle channels increases, the amount of remaining injection liquid inside the nozzle channel may increase, so that the number of nozzle channels is preferably appropriate.

  Here, as described above, in the syringe 20, the nozzle member 31 in which the three nozzle flow paths 3 are formed is fitted into the inner wall surface 21 of the moving passage 4, whereby the path for injecting the syringe into the syringe 20. Is defined. Here, if the upper surface 32 of the nozzle member 31 protrudes toward the moving passage 4, the nozzle member 31 obstructs the movement of the downstream side plug member 10 and the upstream side moving member 8 that move in the moving passage. Therefore, as shown in FIGS. 4A and 4B, the upper surface 32 of the nozzle member 31 is fitted so as to be received in the recess 33 that is recessed from the inner wall surface 21 of the moving passage 4. 4A is a cross-sectional view of the holder 2 (cross-section AA shown in FIG. 4B), and FIG. 4B is a perspective view of the holder 2. FIG. In these drawings, the upper half of the holder 2 is omitted for easy understanding. As shown in these drawings, since the upper surface 32 of the nozzle member 31 is disposed at a position lower than the inner wall surface 21, the opening of the nozzle flow path 3 opens directly into the moving passage 4, and the downstream side plug member 10 and the like. The possibility of inhibiting migration can be eliminated.

<Division mechanism of holder 2>
As described above, in the case of the configuration in which the nozzle member 31 is fitted into the moving passage 4 of the holder 2, when the moving passage 4 is formed in a cylindrical shape as shown in FIG. 2, the nozzle member 31 is placed in the moving passage 4, It is not always possible to easily perform the positioning operation at a predetermined insertion place. In particular, when the nozzle member 31 is relatively small, or when the inner diameter of the moving passage 4 is small, the workability becomes difficult. Therefore, as shown in FIG. 5, the holder 2 may be divided into a lower holder member 40 and an upper holder member 41. In this case, the moving passage 4 and the recess 5 in the holder 2 are also divided corresponding to the upper and lower divisions of the holder 2, and a part of each holder member is formed.

  If comprised in this way, since it does not interfere with the upper holder member 41 when fitting the nozzle member 31 in the inner wall surface of a part of the movement path 4 on the lower holder member 40 side, the fitting becomes easy. In addition, after the nozzle member 31 is fitted into the lower holder member 40, the slide portion 43 provided on the lower holder member 40 and the slide portion 42 provided on the upper holder member 41 are engaged. Thus, both members can be slid in the axial direction of the holder 2 to finally form one holder 2. When the nozzle member 31 is replaced, the upper holder member 41 and the lower holder member 40 are disengaged by sliding and are fitted into the lower holder member 40 in the reverse process. What is necessary is just to remove a nozzle member.

<Attaching holder 2>
In addition, attachment of the holder 2 configured in this manner to the syringe body 1 side will be described with reference to FIGS. 6A and 6B. In the holder 2 formed by assembling the upper holder member 41 and the lower holder member 40 by sliding as described above, the upper holder member 41 is provided with a claw portion 44 protruding to the syringe body 1 side. Further, the lower holder member 40 is similarly provided with a hole 45 in a plate portion projecting toward the syringe body 1 side. Also on the syringe body 1 side, a hole 13 is provided on the upper surface, and a protrusion 12 is provided on the lower surface. Then, as shown in FIGS. 6A and 6B, first, the hole 45 on the holder 2 side is hooked on the protrusion 12 on the syringe body 1 side, and the holder 2 is brought close to the syringe body 1 using this as a rotation axis. Then, the end face of the holder 2 comes into contact with the end face of the syringe body 1 and the claw portion 44 engages with the hole portion 13, whereby the attachment of the syringe body 1 and the holder 2 is completed. In addition, although not shown in the figure, the syringe main bodies that are brought into contact with each other by the above attachment in consideration of the flow of the pressurized injection solution between the through hole 9 of the syringe main body 1 and the moving passage 4 of the holder 2. Between the end surface on the 1 side and the end surface on the holder 2 side, a seal member for preventing liquid leakage such as a gasket is provided.

  Alternatively, the holder 2 may be fixed to the end surface of the syringe main body 1 via a holder cap with a sealing member such as a gasket interposed therebetween. The holder cap has a hook-like cross section so as to be hooked to the holder 2 and is fixed to the syringe body 1 with screws. Thereby, the holder 2 can be firmly fixed.

<Other examples>
As shown in FIG. 7, the holder 2 may be provided with a communication hole 22 that communicates from the recess 5 to the outside of the holder 2. Air can be discharged from the recess 5 to the outside of the holder 2 through the communication hole 22. Therefore, when the downstream side plug member 10 that has moved through the through hole 9 and the movement passage 4 by the pressure generated in the pressure generation unit 6 is accommodated in the recess 5, the downstream side plug member 10 and the inner wall of the recess 5 are surrounded. It is possible to avoid an excessive increase in the air pressure in the space, so that the downstream side plug member 10 can be smoothly accommodated in the recess 5. Here, as described above, in order to suppress the amount of the injection solution remaining in the syringe 1, the inlet of the most downstream nozzle channel 3 is in the state where the downstream side plug member 10 is accommodated in the recess 5. The downstream plug member 10 is disposed so as not to be blocked. By providing the communication hole 22, the downstream plug member 10 is smoothly accommodated in the recess 5, and therefore the relative position between the inlet of the most downstream nozzle flow path 3 and the downstream plug member 10 is good. In other words, it is maintained so that the injection solution can flow from the moving passage 4 to the most downstream nozzle flow path 3 through the introduction port.

  The syringe 20 configured as described above can achieve a suitable injection for a target injection target object by adjusting the pressure generated by the pressure generating unit 6. The injection target of the syringe 20 according to the present invention is a skin structure of a living body such as a human being or a domestic animal. The human skin is composed of the epidermis, dermis, subcutaneous tissue / muscle tissue in layers from the skin surface side to the depth direction, and the epidermis can be distinguished into the stratum corneum, intradermal and layered. Each layer of the skin structure is different also in the main cells constituting the tissue and the characteristics of the tissue. As described above, the human skin structure is generally formed in a layered manner, and inherent anatomical functions are exhibited by cells, tissues, and the like mainly contained in each layer. This means that when a medical treatment or the like is performed on the skin, it is desirable to inject a therapeutic component at the location (depth) of the skin structure according to the treatment purpose. . For example, since dendritic cells are present in the skin, a more effective antigen-antibody reaction can be expected by performing a vaccine injection here.

  In addition, since fibroblasts and collagen cells exist in the dermis, proteins, enzymes, vitamins, amino acids, minerals, sugars, nucleic acids, various growth factors (epithelial cells and fibroblasts) are used to remove skin wrinkles. ) Etc. are injected into the dermis, an effective beauty treatment effect is expected. Also, in hair regeneration treatment, since the hair root is located in the dermis, for hair regeneration treatment, stem cell injection method or stem cell in which hair dermal papilla cells, epidermal stem cells, etc. are self-cultured and autotransplanted into the scalp. It is said that it is preferable to inject several types of growth factors and nutritional components extracted from the above (for example, hair papilla cells, hair root stem cells, epidermal stem cells, HARG cocktail, and hair for transplantation) in the vicinity of the dermis.

  In addition, according to the syringe 20 according to the present invention, in addition to the case where the above-described injection solution is injected into the skin structure, for example, in the field of regenerative medicine, cells to be injected or cultured cells in scaffold tissue / scaffold It is possible to seed stem cells and the like. For example, as disclosed in JP-A-2008-206477, cells that can be appropriately determined by those skilled in the art depending on the site to be transplanted and the purpose of recellularization, such as endothelial cells, endothelial precursor cells, bone marrow cells, and prebones Blast cells, chondrocytes, fibroblasts, skin cells, muscle cells, liver cells, kidney cells, intestinal cells, stem cells, and any other cells considered in the field of regenerative medicine can be injected by the syringe 20. .

  Furthermore, the syringe 20 according to the present invention can also be used for delivery of DNA or the like to cells, scaffold tissues, scaffolds, etc. as described in JP-T-2007-525192. In this case, it can be said that the use of the syringe 20 according to the present invention is more preferable than the case of delivery using a needle because the influence on the cells, the scaffold tissue, the scaffold and the like can be suppressed.

  Furthermore, the syringe 20 according to the present invention is suitable also when various genes, tumor suppressor cells, lipid envelopes, etc. are directly delivered to a target tissue or when an antigen gene is administered to enhance immunity against a pathogen. Used for. In addition, in the field of various disease treatments (fields described in JP2008-508881, JP2010-503616, etc.), immunomedicine (fields described in JP2005-523679, etc.), etc. The syringe 20 can be used, and the field in which it can be used is not intentionally limited.

1 .... Syringe body 2 .... Holder (nozzle holder)
3 .... Nozzle channel (most downstream nozzle channel, other nozzle channels)
4 ... Movement path 5 ... Recess 6 ... Pressure generating part 7 ... Piston 8 ... Upstream side plug member 9 ... Through hole 10 ... Downstream side Plug member 10a ··· Chamfered portion 11 ··· Storage space 12 ··· Projection portion 13 ··· Hole 20 ··· Syringe 21 · · · Inner wall surface 31 · · · Nozzle member 32 ... Upper surface of nozzle member 33 ... Recess 40 ... Lower holder member 41 ... Upper holder member 44 ... Claw 45 ... Hole

Claims (9)

A syringe for injecting an injection target substance into an injection target area without going through an injection needle,
An enclosing portion for enclosing the injectable substance;
A pressurizing unit that pressurizes the injection target substance enclosed in the encapsulating unit;
A flow path section that defines a flow path so that the injection target substance pressurized by the pressurization section is ejected to the injection target area, and
The enclosing portion stores the injection target substance in a storage space formed by being sandwiched between an upstream plug member and a downstream plug member, and the upstream plug member applies a pressure applied by the pressurizing unit to the storage space. Arranged to communicate to the injectable substance in
The channel section is
An accommodating portion for accommodating the downstream plug member moved together with the injection target substance by the pressurization when the pressurization unit is pressurized;
A passage connecting an initial position where the downstream plug member is positioned before pressurization by the pressurizing unit and an accommodation position of the downstream plug member by the accommodating unit, and the downstream plug member by the pressurization A moving path that moves,
A plurality of nozzle flow paths having an introduction port opened to communicate with the moving passage and having an injection port for the injection target substance to the injection target region, wherein the downstream side plug member is accommodated in the accommodation portion In this state, the injection target substance is formed to flow through the nozzle flow path and the moving passage through the introduction port, and the injection ports of the plurality of nozzle flow paths are arranged on the side of the syringe. Arranged in a line along the moving direction so as to open in the direction, and the introduction port of the nozzle channel at the most downstream side is the downstream side plug member in a state where the downstream side plug member is accommodated in the accommodating portion. And a nozzle channel formed at a position where the upstream plug member is not blocked even when the upstream plug member is in contact with the downstream plug member;
Having a needleless syringe. The injection direction of the injection target substance defined by the introduction port and the injection port in the nozzle flow path is the moving direction in which the injection target substance moves together with the downstream side plug member by pressurization of the pressurizing unit. Set to be non-parallel to
The needleless syringe according to claim 1. In the state where the downstream side plug member is accommodated in the accommodation part, the peripheral part of the contact surface of the downstream side plug member with the upstream side plug member, the contact surface of the upstream side plug member of the downstream side plug member The injection target substance circulates through the nozzle channel and the moving passage by a chamfered portion provided in at least one of the peripheral edge or the peripheral edge of the inlet of the nozzle channel,
The needleless syringe according to claim 1 or 2 . The flow path portion further includes a nozzle member including the nozzle flow path,
The nozzle member is fitted on the inner wall surface of the moving passage so that the inlet of the nozzle channel is located on the moving passage side,
The needleless syringe according to any one of claims 1 to 3 . In a state where the nozzle member is fitted into the inner wall surface of the moving passage, the inlet of the nozzle channel is located in a recess recessed from the inner wall surface of the moving passage.
The needleless syringe according to claim 4 . A member that includes the moving passage and the accommodating portion and holds the nozzle member in a detachable manner, is fixed to the main body of the syringe with the nozzle member held, and is pressurized by the pressure portion A holding member that guides the injected substance to the nozzle flow path through the moving passage;
The holding member is formed by combining a plurality of divided elements so that the nozzle member can be attached to and detached from a part of the inner wall surface of the moving path included in the one divided element. It is formed,
The needleless syringe according to claim 4 or 5 . The channel section is
A communication hole that allows communication between the housing portion and the outside of the syringe;
The needleless syringe according to any one of claims 1 to 6 . A syringe body including the enclosing part, the pressurizing part, and the flow path part;
The moving direction is a direction from the rear end side of the syringe body toward the front end side ,
The needleless syringe according to any one of claims 1 to 7 . The inner diameter of the housing space and the inner diameter of the moving passage are substantially the same,
The inner diameter of each of the accommodation space, the movement passage, and the accommodation portion is substantially constant over the movement direction.
The needleless syringe according to any one of claims 1 to 8 .

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