JP5824112B2 - Isolator and control method of isolator - Google Patents

Description

  The present invention relates to an isolator and an isolator control method.

  For example, in an isolator used for work handling biological materials such as cell culture, in order to prevent contamination other than substances necessary for work, the inside of a work box or a pass box for carrying goods necessary for work is not limited. It is necessary to create a dust-free and aseptic environment (hereinafter referred to as an aseptic environment). Hereinafter, in order to realize an aseptic environment, processing for killing microorganisms and the like is referred to as decontamination, and the decontamination processing includes processing such as so-called sterilization, sterilization, and sterilization.

  For example, in the sterilizing liquid vaporizer disclosed in Patent Document 1, hydrogen peroxide is used as a decontamination substance used for the decontamination treatment, and heated compressed air and hydrogen peroxide water are mixed with an atomizer and atomized. To produce hydrogen peroxide gas.

  In this way, a decontamination gas such as a hydrogen peroxide gas containing a decontamination substance can be generated and supplied into a decontamination target chamber such as a work room or a pass box, and decontamination processing can be performed.

JP 2003-339829 A

  In order to remove impurities such as dust contained in the gas to be sucked and exhausted, the work chamber of the isolator and the intake / exhaust port of the pass box, such as HEPA (High Efficiency Particulate Air) filter and ULPA (Ultra Low Penetration Air) filter, etc. An air filter is provided. However, depending on the combination of the decontamination gas and the air filter used, the air filter adsorbs the decontamination gas, for example, when hydrogen peroxide gas is used as the decontamination gas and a HEPA filter is used as the air filter. It may have easy properties.

  For this reason, if decontamination gas is supplied from the air inlet of a work room or pass box, the decontamination gas is adsorbed to the air filter. It was necessary to supply a decontamination gas, which was inefficient. On the other hand, when the decontamination gas is supplied to the work chamber or the pass box without passing through the air filter, the air filter (intake filter) at the intake port cannot be sufficiently decontaminated.

The main present invention that solves the above-described problems is a decontamination target chamber having an intake port equipped with an intake filter and an exhaust port equipped with an exhaust filter, and sucks outside air into the decontamination target chamber via the intake filter. A first flow path, a second flow path for exhausting gas in the decontamination target chamber via the exhaust filter, and intake of outside air into the decontamination target chamber via the first flow path. A blower for generating an air flow for exhausting the gas in the decontamination target chamber through the second flow path, and supplying the decontamination gas into the decontamination target chamber without passing through the intake filter and the exhaust filter. A decontamination gas supply unit; a pressure sensor that measures an internal pressure of the decontamination target chamber; and the blower, the decontamination gas supply unit, and a control unit connected to the pressure sensor, the decontamination gas supply In the decontamination target room A sprayer for spraying a sterilizing substance, a pump for supplying the sterilizing substance to the sprayer, and a compressor for supplying air to the sprayer, and the control unit drives the compressor. Then, air is supplied from the sprayer into the decontamination target chamber to pressurize the decontamination target chamber, and based on the internal pressure of the decontamination target chamber measured by the pressure sensor, the airtightness of the decontamination target chamber This is an isolator that performs a leak test to inspect

  Other features of the present invention will become apparent from the accompanying drawings and the description of this specification.

  ADVANTAGE OF THE INVENTION According to this invention, the efficiency of the decontamination process of a decontamination object room and an intake filter can be improved.

It is a block diagram which shows the structure of the isolator in one Embodiment of this invention. It is a block diagram which shows the state of each valve | bulb, each air blower, the compressor Cm, and the pump Pm in leak test mode. It is a block diagram which shows the state of each valve | bulb, each air blower, compressor Cm, and pump Pm in decontamination gas generation mode. It is a figure explaining control of valve V3 in decontamination gas generation mode and decontamination gas exposure mode. It is a block diagram which shows the state of each valve | bulb, each air blower, the compressor Cm, and the pump Pm in decontamination gas exposure mode. It is a block diagram which shows the state of each valve | bulb, each air blower, the compressor Cm, and the pump Pm in the decontamination gas exhaust mode and the aseptic operation mode. It is a block diagram which shows the other structural example of an isolator. FIG. 8 is a block diagram illustrating states of each valve, each blower, a compressor Cm, and a pump Pm in the decontamination gas generation mode in the isolator illustrated in FIG. 7.

  At least the following matters will become apparent from the description of this specification and the accompanying drawings.

=== Configuration of Isolator ===
Hereinafter, with reference to FIG. 1, the structure of the isolator in one Embodiment of this invention is demonstrated. In this embodiment, hydrogen peroxide is used as an example of a decontamination material used for the decontamination treatment, and a decontamination effect is obtained by exposing a predetermined concentration of hydrogen peroxide gas to a space to be decontaminated for a certain period of time. To get.

  The isolator shown in FIG. 1 is configured to include a control unit 1a, an operation unit 2a, and a decontamination gas supply unit 3a with a work chamber 4 for performing work in an aseptic environment as a decontamination target chamber. . The working chamber 4 has an intake port provided with an (intake) filter F1 and an exhaust port provided with an (exhaust) filter F2, and these intake and exhaust ports have a flow path constituted by pipes, tubes, and the like. P1 to P3 are provided. Furthermore, a pressure sensor 41 that measures the internal pressure IP1 of the work chamber 4 is provided in the work chamber 4. The filters F1 and F2 are air filters for removing impurities such as dust contained in the gas to be sucked and exhausted. For example, HEPA filters are used.

  The (first) flow path P1 is a flow path for sucking outside air into the working chamber 4 through the filter F1, and on the flow path P1, a catalyst C1, a blower (blower / fan) B1, and A (first) valve V1 is provided. Further, the blower B1 is, for example, a centrifugal multiblade fan, and generates an air flow that draws outside air into the work chamber 4 via the flow path P1 in accordance with the control signal Sb1. And by the said air flow, external air flows in through the catalyst C1, and is further supplied in the working chamber 4 through the filter F1. The valve V1 is provided between the blower B1 and the filter F1, and opens and closes the flow path P1 according to the control signal Sv1.

  The (second) flow path P2 is a flow path for exhausting the gas in the working chamber 4 through the filter F2. On the flow path P2, the blower B2, the catalyst C2, and the (second) A valve V2 is provided. The blower B2 is, for example, a centrifugal multiblade fan, and generates an air flow that exhausts the gas in the work chamber 4 through the flow path P2 in accordance with the control signal Sb2. Then, the gas in the working chamber 4 flows out through the filter F2 by the air flow, and hydrogen peroxide (decontamination substance) is decomposed / detoxified through the catalyst C2 and then discharged to the outside. . In the present embodiment, the catalyst C2 corresponds to a detoxification unit that detoxifies the decontamination substance. The valve V2 is provided between the catalyst C2 and the filter F2, and opens and closes the flow path P2 according to the control signal Sv2.

  The (third) flow path P3 is a flow path for exhausting the gas in the working chamber 4 through the filter F1 in the decontamination gas generation mode and the decontamination gas exposure mode described later. Generally, the flow path P1 And the flow rate is less than P2. Further, one end of the flow path P3 is connected between the catalyst C2 and the valve V2 in the flow path P2, and the other end is connected to the filter F1, and a (third) valve V3 is provided on the flow path P3. Is provided. The valve V3 opens and closes the flow path P3 according to the control signal Sv3.

  The decontamination gas supply unit 3a includes a tank 31, a bottle 32, a water level sensor 33, a sprayer 34, and a filter F32. Further, flow paths P31 to P33 including pipes and tubes connect these. It is provided as follows.

  The flow path P31 connects between the tank 31 and the bottle 32, and a pump Pm and a filter F31 are provided on the flow path P31. Further, the pump Pm is as dustless and aseptic as possible, for example, a peristaltic type is used, and hydrogen peroxide solution (an aqueous solution of decontamination substance) stored in the tank 31 according to the control signal Spm. ). And the taken-in hydrogen peroxide solution is sent to the sprayer 34 side through the (filter) filter F31 for removing impurities, such as dust.

  The bottle 32 is opened to the outside air via an (air) filter F32, and a buffer for recovering hydrogen peroxide water that has not been ejected as hydrogen peroxide gas (decontamination gas) from the nozzle of the sprayer 34. Function as. Further, the bottle 32 is provided with a water level sensor 33 for measuring the water level WL1 of the collected hydrogen peroxide solution.

  One end of the flow path P32 is connected between the filter F31 and the bottle 32 in the flow path P31, the other end is connected to a lower port of the sprayer 34, and a valve V31 is provided on the flow path P32. It has been. The valve V31 opens and closes the flow path P32 according to the control signal Sv31.

  The flow path P33 is a flow path for supplying compressed air (compressed gas) to the sprayer 34. On the flow path P33, a compressor (compressor) Cm, a filter F33, and a valve V32 are provided. Further, the compressor Cm takes in outside air in accordance with the control signal Scm and compresses the compressed air, and the compressed air passes through the (air) filter F33 for removing impurities such as dust and moisture and is placed on the upper side of the sprayer 34. Supplied to the port. The valve V32 is provided between the filter F33 and the upper port of the sprayer 34, and opens and closes the flow path P33 according to the control signal Sv32.

  The mode selection signal SLm is input from the operation unit 2a to the control unit 1a, and the control unit 1a switches an operation mode to be described later according to the mode selection signal SLm. In addition to the operation mode, the control unit 1a controls the control signals Sv1 to Sv3, Sv31, Sv32 for controlling each valve, each blower, the compressor Cm, and the pump Pm based on the internal pressure IP1 and the water level WL1. Sb1, Sb2, Scm, and Spm are output.

=== Operation of Isolator ===
The operation of the isolator in this embodiment will be described below with reference to FIGS. 2 to 6 as appropriate.

  The operation mode of the isolator of the present embodiment is switched according to the mode selection signal SLm, and a decontamination operation mode (SLm = 1 to 4) for decontaminating the work room 4 (decontamination target room), and decontamination Thus, it can be roughly divided into aseptic operation mode (SLm = 5) for performing work in the working chamber 4 which has become an aseptic environment. The decontamination operation modes include a leak test mode (SLm = 1), a decontamination gas generation mode (SLm = 2), a decontamination gas exposure mode (SLm = 3), and a decontamination gas exhaust mode (SLm = 4). Consists of.

  In the decontamination operation mode, first, the airtightness of the work chamber 4 is inspected in the leak test mode. In the leak test mode, as shown in FIG. 2, the control unit 1a stops the blowers B1, B2 and the pump Pm, and drives the compressor Cm with the valves V1 to V3 and V31 closed. Open valve V32. And by the said control, the sprayer 34 of the decontamination gas supply part 3a supplies only the compressed air supplied to the upper port from the nozzle into the work chamber 4, and pressurizes the inside of the work chamber 4.

  The controller 1a determines the airtightness of the work chamber 4 based on the internal pressure IP1 of the work chamber 4 measured by the pressure sensor 41 in a state where the inside of the work chamber 4 is pressurized as described above. For example, the control unit 1a determines that the airtightness of the work chamber 4 is good when the amount of decrease in the internal pressure IP1 after a predetermined time has elapsed is equal to or less than a predetermined pressure.

  If it is determined that the airtightness of the work chamber 4 is good in the leak test mode, then hydrogen peroxide gas is supplied into the work chamber 4 in the decontamination gas generation mode. In the decontamination gas generation mode, as shown in FIG. 3, the controller 1a drives the pump Pm, opens the valve V31, and controls the opening and closing of the valve V3 from the state in the leak test mode.

  By this control, compressed air is supplied to the upper port of the sprayer 34 as in the leak test mode. In addition, a negative pressure is generated by jetting compressed air from the nozzle of the sprayer 34, and the negative pressure causes the liquid to be sent from the tank 31 to the sprayer 34 side by the pump Pm to the lower port of the sprayer 34. Hydrogen peroxide water is supplied. Then, the compressed air and the hydrogen peroxide solution are mixed in the sprayer 34, sprayed as a mist-like hydrogen peroxide solution, immediately vaporized, and supplied as hydrogen peroxide gas.

  Thus, in the isolator of this embodiment, hydrogen peroxide gas is directly supplied into the working chamber 4 without passing through the filters F1 and F2 in the decontamination gas generation mode. Therefore, since the hydrogen peroxide gas is supplied into the work chamber 4 without being reduced by adsorption by the filters F1 and F2, the decontamination process in the work chamber 4 can be efficiently performed.

  In addition, the decontamination gas supply part 3a can produce | generate hydrogen peroxide gas, without heating or using an ultrasonic wave by utilizing the negative pressure which generate | occur | produces by injection of compressed air. In addition, when the supply of compressed air to the sprayer 34 is stopped due to some trouble, the hydrogen peroxide solution fed by the pump Pm is recovered by the bottle 32 due to the difference in flow path resistance due to the flow path diameter difference. It is not supplied into the working chamber 4 as it is. Then, when the water level WL1 of the hydrogen peroxide solution measured by the water level sensor 33 becomes equal to or higher than the predetermined water level, the control unit 1a stops the pump Pm and stops the hydrogen peroxide solution feeding.

  In the decontamination gas generation mode, the controller 1a further controls opening and closing of the valve V3 based on the internal pressure IP1 of the work chamber 4. For example, as shown in FIG. 4, when the internal pressure IP1 exceeds a predetermined positive pressure IPtg, the valve V3 is opened, and when the internal pressure IP1 becomes equal to or lower than the predetermined positive pressure IPtg, the valve V3 is closed. When the valve V3 is opened, the hydrogen peroxide gas in the work chamber 4 is exhausted through the filter F1. Since the valve V3 has a smaller allowable flow rate than the valves V1 and V2 and has a good response, the control unit 1a can control the internal pressure IP1 with high accuracy.

  Thus, in the isolator of this embodiment, in the decontamination gas generation mode, the hydrogen peroxide gas in the work chamber 4 is passed through the filter F1 while adjusting the internal pressure IP1 of the work chamber 4 to the predetermined positive pressure IPtg. Exhaust. Therefore, the filter F1 that is an intake filter can be sufficiently decontaminated.

  After supplying the hydrogen peroxide gas into the work chamber 4 in the decontamination gas generation mode, the work chamber 4 is exposed to the hydrogen peroxide gas in the decontamination gas exposure mode. In the decontamination gas exposure mode, the controller 1a stops the pump Pm and closes the valve V31 from the state in the decontamination gas generation mode, as shown in FIG. By this control, the decontamination gas supply unit 3a supplies only compressed air from the nozzle into the working chamber 4 as in the leak test mode, and the control unit 1a further performs the decontamination gas generation mode. Similarly, the valve V3 is controlled to open and close based on the internal pressure IP1 of the working chamber 4.

  Thus, in the isolator of this embodiment, in the decontamination gas exposure mode, the inside of the working chamber 4 is exposed with the hydrogen peroxide gas supplied in the decontamination gas generation mode. Also in the decontamination gas exposure mode, the hydrogen peroxide gas in the work chamber 4 is exhausted through the filter F1 while adjusting the internal pressure IP1 of the work chamber 4 to a predetermined positive pressure IPtg. Therefore, by shifting to the decontamination gas exposure mode after the decontamination gas generation mode, the inside of the work chamber 4 and the filter F1 are sufficiently decontaminated while suppressing the consumption of the hydrogen peroxide solution stored in the tank 31. be able to.

  In the decontamination gas exposure mode, the work chamber 4 is sufficiently exposed with hydrogen peroxide gas, and then the hydrogen peroxide gas in the work chamber 4 is exhausted in the decontamination gas exhaust mode. In the decontamination gas exhaust mode, as shown in FIG. 6, the controller 1a drives the blowers B1 and B2 from the state in the decontamination gas exposure mode, opens the valves V1 and V2, closes the valve V3, The compressor Cm is stopped and the valve V32 is closed.

  By this control, the decontamination gas supply unit 3a stops the supply of compressed air and hydrogen peroxide gas into the work chamber 4. Moreover, the control part 1a controls the rotation speed of blower B1 and B2 based on the internal pressure IP1 of the working chamber 4, and the internal pressure of the working chamber 4 is the same as in the decontamination gas generation mode and the decontamination gas exposure mode. IP1 is adjusted to a predetermined positive pressure IPtg. Therefore, outside air is sucked into the work chamber 4 through the flow path P1, and hydrogen peroxide gas in the work chamber 4 is exhausted through the flow path P2. Then, by continuing this operation for a predetermined time, the hydrogen peroxide gas in the working chamber 4 is replaced with fresh fresh air.

  In the isolator of this embodiment, the filter F2 that is an exhaust filter is decontaminated in the decontamination gas exhaust mode. Further, after the hydrogen peroxide gas in the working chamber 4 is sufficiently exhausted in the decontamination gas exhaust mode, the operation shifts to the aseptic operation mode. The control in the aseptic operation mode is the same as in the decontamination gas exhaust mode. .

=== Other configuration examples of the isolator ===
In the said embodiment, although only the working chamber 4 was made into the decontamination object chamber, it is not limited to this. For example, as shown in FIG. 7, in addition to the work chamber 4, a pass box 5 for carrying articles necessary for work into the work chamber 4 through a door 52 may be a decontamination target chamber. In addition, the structure for decontaminating the working chamber 4 side is the same as that of the isolator of the said embodiment, and is abbreviate | omitted except the sprayer 34 etc. in FIG. In the following, the description of the configuration common to the above embodiment for decontaminating the work chamber 4 side will be omitted.

  The isolator shown in FIG. 7 includes a control unit 1b, an operation unit 2b, and a decontamination gas supply unit 3b. Further, the pass box 5 has an intake port provided with an (intake) filter F3 and an exhaust port provided with an (exhaust) filter F4. These intake and exhaust ports are provided with flow paths P4 to P6. . Further, a pressure sensor 51 for measuring the internal pressure IP2 of the pass box 5 is provided in the pass box 5.

  The (first) flow path P4 is a flow path for sucking outside air into the pass box 5 through the filter F3. On the flow path P4, the catalyst C3, the (first) valve V4, and A blower B3 is provided. On the other hand, the (second) flow path P5 is a flow path for exhausting the gas in the pass box 5 through the filter F4, and the catalyst C4 and the (second) valve V5 are disposed on the flow path P5. Is provided. The blower B3 is an axial flow fan, for example, and sucks outside air into the pass box 5 through the flow path P4 and gas in the pass box 5 through the flow path P5 according to the control signal Sb3. Generates an airflow that exhausts air. In addition, since the capacity | capacitance of the pass box 5 is small compared with the working chamber 4, intake / exhaust is performed with one air blower B3.

  And by the said air flow, external air flows in through the catalyst C3, is further supplied into the pass box 5 through the filter F3, the gas in the pass box 5 flows out through the filter F4, and further passes through the catalyst C4. Thus, hydrogen peroxide is decomposed / detoxified and discharged to the outside. The valve V4 is provided between the catalyst C3 and the blower B3, and opens and closes the flow path P4 according to the control signal Sv4. The valve V5 is provided between the catalyst C4 and the filter F4, and the control signal Sv5. Accordingly, the flow path P5 is opened and closed.

  The (third) flow path P6 is a flow path for exhausting the gas in the pass box 5 through the filter F3 in the decontamination gas generation mode and the decontamination gas exposure mode. Further, one end of the flow path P6 is connected between the catalyst C4 and the valve V5 in the flow path P5, and the other end is connected to the filter F3. On the flow path P6, a (third) valve V6 is connected. Is provided. The valve V6 opens and closes the flow path P6 according to the control signal Sv6.

  The decontamination gas supply unit 3b includes a tank 31, bottles 32 and 35, water level sensors 33 and 36, sprayers 34 and 37, and filters F32 and F34, and further, flow paths P31 to P36 connect them. It is provided as follows.

  The flow path P31 connects between the tank 31 and the bottles 32 and 35, and a pump Pm, a filter F31, and a valve V35 are provided on the flow path P31. Further, the pump Pm takes in the hydrogen peroxide solution stored in the tank 31 in accordance with the control signal Spm, and sends it to the nebulizers 34 and 37 through the (filter) filter F31. Further, the valve V35 allows the hydrogen peroxide solution filtered by the filter F31 to pass to the sprayer 34 side or the sprayer 37 side according to the control signal Sv35.

  The bottle 32 is opened to the outside air via an (air) filter F32, and the bottle 32 is provided with a water level sensor 33 for measuring the water level WL1 of the hydrogen peroxide solution. On the other hand, the bottle 35 is opened to the outside air via an (air) filter F34, and the bottle 35 is provided with a water level sensor 36 for measuring the water level WL2 of the hydrogen peroxide solution.

  One end of the flow path P32 is connected between the valve V35 and the bottle 32 in the flow path P31, the other end is connected to a lower port of the sprayer 34, and a valve V31 is provided on the flow path P32. It has been. On the other hand, one end of the flow path P34 is connected between the valve V35 and the bottle 35 in the flow path P31, the other end is connected to the lower port of the sprayer 37, and the valve V33 is placed on the flow path P34. Is provided. The valve V31 opens and closes the flow path P32 according to the control signal Sv31, and the valve V33 opens and closes the flow path P34 according to the control signal Sv33.

  The flow path P33 is a flow path for supplying compressed air to the sprayer 34 or 37, and is branched into a flow path P35 connected to the sprayer 34 and a flow path P36 connected to the sprayer 37. A compressor Cm and a filter F33 are provided on the flow path P33, and valves V32 and V34 are provided on the flow paths P35 and P36, respectively. Further, the compressor Cm takes in and compresses outside air according to the control signal Scm, and the compressed air is supplied to the upper port of the sprayer 34 or 37 via the (air) filter F33. The valve V32 is provided between the filter F33 and the upper port of the sprayer 34, and opens and closes the flow path P35 according to the control signal Sv32. The valve V34 is connected to the filter F33 and the upper port of the sprayer 37. It is provided in between and opens and closes the flow path P36 according to the control signal Sv34.

  The decontamination target room selection signal SLr and the mode selection signal SLm are input from the operation unit 2b to the control unit 1b. Further, the control unit 1b selects the work room 4 or the pass box 5 as a decontamination target room according to the decontamination target room selection signal SLr, and switches the operation mode according to the mode selection signal SLm. In addition to the decontamination target chamber and the operation mode, the control unit 1b generates control signals Sv1 to Sv6, Sv31 to Sv35, Sb1 to Sb3, Scm, and Spm based on the internal pressures IP1, IP2, and the water levels WL1, WL2. Output. The decontamination gas supply unit 3b supplies compressed air or hydrogen peroxide gas into the decontamination target chamber selected according to the decontamination target chamber selection signal SLr.

  Also in the isolator shown in FIG. 7, the operation mode is switched according to the mode selection signal SLm and is controlled in the same manner as the isolator of the above embodiment. For example, in the decontamination gas generation mode for the pass box 5, as shown in FIG. 8, the decontamination gas supply unit 3b is supplied with compressed air to the upper port of the sprayer 37 and negative pressure is applied to the lower port. Hydrogen oxide water is supplied, and hydrogen peroxide gas is supplied directly into the pass box 5. Further, the control unit 1b controls the opening and closing of the valve V6 based on the internal pressure IP2 of the pass box 5 to adjust the internal pressure IP2 of the pass box 5 to a predetermined positive pressure IPtg, while passing through the filter F3. Exhaust hydrogen peroxide gas.

  As described above, in the decontamination gas generation mode of the isolator shown in FIG. 1 (FIG. 7), the decontamination target chamber does not pass through the filter F1 (F3) as the intake filter and the filter F2 (F4) as the exhaust filter. By supplying hydrogen peroxide gas, which is a decontamination gas, directly into the work chamber 4 (pass box 5), and exhausting the decontamination gas in the chamber to be decontaminated through an intake filter, a sufficient amount of decontamination is obtained. Dye gas can be supplied into the room to be decontaminated, and the intake filter can be sufficiently decontaminated. Therefore, the efficiency of the decontamination process in the decontamination target chamber and the intake filter can be improved.

  Further, in the decontamination gas generation mode, while supplying the decontamination gas from the decontamination gas supply unit 3a (3b) into the decontamination target chamber, the blowers B1 and B2 (B3) are stopped and the air is sucked by the blower With the first flow path P1 (P4) and the second flow path P2 (P5) for exhausting closed, the third flow path P3 (P6) opened and closed by the third valve V3 (V6) is opened. Accordingly, the decontamination gas in the decontamination target chamber can be exhausted through the intake filter and the third flow path, and the intake filter can be sufficiently decontaminated.

  Further, a catalyst C2 (C4) for decomposing the decontaminating substance is provided on the side farther (away from) the exhaust filter than the second valve V2 (V5) that opens and closes the second channel, and the third channel is provided. By connecting one end of the catalyst between the catalyst and the second valve and connecting the other end to the intake filter, not only in the decontamination gas exhaust mode and aseptic operation mode, but also in the decontamination gas generation mode and The decontamination substance contained in the decontamination gas exhausted in the decontamination gas exposure mode can be decomposed and rendered harmless and then discharged to the outside.

  In the decontamination gas generation mode, the internal pressure of the decontamination target chamber is controlled by opening and closing the third valve based on the internal pressure IP1 (IP2) of the decontamination target chamber measured by the pressure sensor 41 (51). While adjusting to a predetermined positive pressure IPtg, the decontamination gas in the decontamination target chamber can be exhausted through the intake filter.

  In the decontamination gas generation mode, the compressed air and the decontamination substance are mixed to generate a decontamination gas, which is supplied to the decontamination target chamber. Then, in the decontamination gas exposure mode, only the compressed air is removed. The third valve is controlled to open and close in the same manner as in the decontamination gas generation mode while being supplied into the decontamination target chamber, thereby sufficiently decontaminating the decontamination target chamber and the intake filter while suppressing consumption of the decontamination substance be able to.

  In addition, by supplying only compressed air to the decontamination target chamber with all of the first to third flow paths closed, the airtightness of the decontamination target chamber is inspected based on the internal pressure of the decontamination target chamber. Can do.

  In addition, the said embodiment is for making an understanding of this invention easy, and is not for limiting and interpreting this invention. The present invention can be changed and improved without departing from the gist thereof, and the present invention includes equivalents thereof.

DESCRIPTION OF SYMBOLS 1a, 1b Control part 2a, 2b Operation part 3a, 3b Decontamination gas supply part 4 Working room 5 Pass box 31 Tank 32, 35 Bottle 33, 36 Water level sensor 34, 37 Sprayer 41, 51 Pressure sensor 52 Door P1-P6, P31-P36 Channel (Pipe / Tube)
F1-F4, F31-F34 Filter C1-C4 Catalyst V1-V6, V31-V35 Valve B1-B3 Blower (Blower / Fan)
Cm Compressor
Pm pump

Claims (7)

A decontamination chamber having an intake port with an intake filter and an exhaust port with an exhaust filter;
A first flow path for sucking outside air into the decontamination target chamber through the intake filter;
A second flow path for exhausting the gas in the decontamination target chamber through the exhaust filter;
A blower for generating an air flow for sucking outside air into the decontamination target chamber through the first flow path and exhausting the gas in the decontamination target chamber through the second flow path;
A decontamination gas supply unit for supplying a decontamination gas into the decontamination target chamber without passing through the intake filter and the exhaust filter;
A pressure sensor for measuring an internal pressure of the decontamination target chamber ;
A control unit connected to the blower, the decontamination gas supply unit and the pressure sensor;
The decontamination gas supply unit
And sprayer for spraying air or sterilizing material to the decontamination object chamber,
A pump for supplying the sterilizing substance to the sprayer;
A compressor for supplying air to the sprayer ,
Wherein the control unit, the decontamination object chamber measured by the pressure sensor with pressurizing the inside of the decontaminated object chamber by supplying air into the decontaminated object chamber from the sprayer by driving the compressor Performing a leak test to inspect the air tightness of the decontamination target room based on the internal pressure of
Isolator. A first valve provided between the sprayer and the pump;
The controller performs the leak test after closing the first valve;
The isolator according to claim 1. Wherein the control unit, the rear leak test, by opening the first valve with driving the pump, the jetting decontamination target chamber by mixing the sterilizing agent and the air in the atomizer,
The isolator according to claim 2. A second valve provided between the sprayer and the compressor;
The controller performs the leak test after opening the second valve;
The isolator as described in any one of Claims 1-3. A filter provided between the sprayer and the compressor;
The isolator as described in any one of Claims 1-4. A decontamination target chamber having an intake port provided with an intake filter and an exhaust port provided with an exhaust filter, a first flow path for taking outside air into the decontamination target chamber via the intake filter, and the exhaust filter. A second flow path for exhausting the gas in the decontamination target chamber through the first flow path, and sucking outside air into the decontamination target chamber through the first flow path, and the second flow path through the second flow path. A blower that generates an air flow for exhausting the gas in the decontamination target chamber, a decontamination gas supply unit that supplies the decontamination gas into the decontamination target chamber without passing through the intake filter and the exhaust filter, and the decontamination target A pressure sensor for measuring an internal pressure of the chamber, and a control unit connected to the blower, the decontamination gas supply unit, and the pressure sensor, and the decontamination gas supply unit includes air or Nebulizer for spraying sterile substances A pump for supplying the sterilizing material to the atomizer, a control method of an isolator having a compressor for supplying air to said atomizer,
A first step of pressurizing the inside of the decontaminated object chamber by supplying air into the decontaminated object chamber from the sprayer by driving the compressor,
A second step of measuring the internal pressure of the pressurized decontamination target chamber with the pressure sensor and inspecting the airtightness of the decontamination target chamber , and
Control method of isolator. Wherein the compressor is driven to drive the pump supplies air to the atomizer by supplying sterilizing material to the atomizer, injecting into the decontaminated object chamber by mixing the air and sterilizing material in the sprayer Further comprising a third step,
The method for controlling an isolator according to claim 6.

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