JP5807901B2 - Lymph age estimation system, lymph age estimation method, and lymph age estimation program - Google Patents

Description

  One embodiment of the present invention relates to a lymph age estimation system, a lymph age estimation method, and a lymph age estimation program.

  Lymph vessels are stretched along with blood vessels in all tissues and organs of the body, and are responsible for defense against external enemies, immunity, waste discharge, and the return of fluid and protein to veins. Lymph flowing in the lymphatic vessel is pushed out by the autonomic contraction ability (pump function) of the lymphatic vessel in the collecting lymphatic vessel, and flows into the vein from the periphery of the extremity through the trunk and the thoracic duct.

  As a technique for measuring the pressure (lymph pressure) of lymph flowing in the lymph vessel, there is a lymph pressure measuring system described in Patent Document 1 below. This system displays the fluorescence image emitted from the fluorescent dye injected into the lymphatic vessel, gradually reduces the pressure of the Manchette, and the pressure at the time when the lymph flow blocked by the Manchette resumes is used as the lymph pressure. taking measurement.

International Publication No. 2010/137358 Pamphlet

  If the aging state of the person's lymphatic function can be grasped using the measured lymphatic pressure, there is a great advantage from a health or medical standpoint. In other words, if the lymph age of a person can be easily estimated using lymphatic pressure, it is possible to estimate the youth of the individual lymph relative to the average value, the degree of aging, etc. It becomes a hand.

  The lymph age estimation system according to an aspect of the present invention assigns a measurement value received by a reception unit to a reception unit that receives a measurement value of a subject's lymph pressure and a function indicating a relationship between a person's age and lymph pressure. And calculating means for calculating the estimated lymph age of the subject.

  A lymph age estimation method according to one aspect of the present invention is a lymph age estimation method executed by a computer, and shows a relationship between a reception step of receiving a measurement value of a subject's lymph pressure and a person's age and lymph pressure. A calculation step of calculating the estimated lymph age of the subject by substituting the measurement value received in the reception step into the function.

  The lymph age estimation program according to an aspect of the present invention is a computer that accepts a measurement value received by a reception unit in a reception unit that receives a measurement value of a subject's lymph pressure and a function that indicates a relationship between a person's age and lymph pressure. By substituting the value, the calculation means for calculating the estimated lymph age of the subject is executed.

  According to such a form, the estimated lymph age of the subject is calculated by substituting the measured value of the lymph pressure into a function indicating the relationship between the age of the person and the lymph pressure prepared in advance. Thereby, a person's age can be estimated simply.

  In the lymph age estimation system according to an aspect of the present invention, the function is represented by y = f (x), where age is an independent variable x and lymph pressure is a dependent variable y, and in the assumed range of the independent variable x. It may be a decreasing function.

  In the lymph age estimation system according to an aspect of the present invention, the function may be an n-order function.

  In the lymph age estimation system according to one embodiment of the present invention, n may be 3 or more.

  In the lymph age estimation system according to an aspect of the present invention, the function may be an exponential function.

  In the lymph age estimation system according to an aspect of the present invention, the function may be indicated by a sum of a plurality of functions.

  In the lymph age estimation system according to an aspect of the present invention, the function includes a first function for calculating the estimated lymph age of the male and a second function for calculating the estimated lymph age of the female, The calculation means selects a function corresponding to the data indicating the sex of the subject from the first and second functions, and calculates the estimated lymph age of the subject by substituting the measurement value into the selected function. Good.

  According to one aspect of the present invention, the lymph age of a person can be easily estimated using the lymph pressure.

It is a figure which shows the example of a function structure of the lymph age estimation system which concerns on embodiment. It is a schematic diagram which shows the example of the manchette shown in FIG. (A)-(e) is a schematic diagram which shows a mode that a fluorescent pigment | dye moves along a lymphatic vessel. It is a figure which shows the example of the hardware constitutions of the lymph age estimation system shown in FIG. It is a graph which shows the example of the statistics (gender mixing) of the measured value of lymphatic pressure, and the example of the function based on the result. It is a graph which shows the example of the statistics (only a man) of the measured value of lymphatic pressure, and the example of the function based on the result. It is a graph which shows the example of the statistics (only a woman) of the measured value of lymphatic pressure, and the example of the function based on the result. It is a graph which shows the example of the statistics (gender mixing) of the measured value of lymphatic pressure, and the example of the function based on the result. It is a graph which shows the example of the statistics (only a man) of the measured value of lymphatic pressure, and the example of the function based on the result. It is a graph which shows the example of the statistics (only a woman) of the measured value of lymphatic pressure, and the example of the function based on the result. It is a flowchart which shows operation | movement of the lymph age estimation system shown in FIG. It is a figure which shows the structural example of the lymph age estimation program which concerns on embodiment.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the description of the drawings, the same or equivalent elements are denoted by the same reference numerals, and redundant description is omitted.

  The function and configuration of the lymph age estimation system 2 according to the embodiment will be described with reference to FIGS. The lymph age estimation system 2 is a computer system that receives an input of a subject's lymph pressure measured by the lymph pressure measurement system 1 and estimates the subject's lymph age from the lymph pressure. The lymph age estimation system 2 and the lymph pressure measurement system 1 are connected by a wired or wireless communication line. Here, the lymph age is an index that shows the function of a person's lymph in terms of age, and by this, for example, the youth of the lymph and the degree of aging can be grasped.

  In order to estimate lymph age by measuring lymphatic pressure, a fluorescent dye is administered in advance to the skin or subcutaneous tissue of a subject. The administered fluorescent dye then enters the lymphatic vessels. Examples of fluorescent dyes include indocyanine green and fluorescent dextran.

  First, the function and configuration of the lymph pressure measurement system 1 that supplies data to the lymph age estimation system 2 will be described. The lymph pressure measurement system 1 is also described in Patent Document 1 described above.

  The lymph pressure measurement system 1 is a group of devices used for measuring the lymph pressure of a human limb. The lymph pressure measurement system 1 includes a manchette 10, a fluorescence intensity meter 20, and a pressure measurement device 30 as functional components.

  The manchette 10 is attached so as to cover a part of a human arm or leg. Below, the attachment part of a manchette and its vicinity are called living body observation part. The manchette 10 is provided with an air bag (not shown), and when the air is sent into the air bag by the pressure measuring device 30, the covered portion (the living body observation portion) is pressurized. As shown in FIG. 2, the manchette 10 has a belt-like shape and is fixed to the arm or leg by a pair of hook-and-loop fasteners 11 provided at both edges extending along the insertion direction of the arm or leg (arrow A in the figure). The The manchette 10 may have a cylindrical shape through which an arm or a leg can be passed.

  As shown in FIG. 2, the manchette 10 includes a first detection unit 12 and a second detection unit 13. For convenience, in this specification, when the manchette 10 is attached to the living body observation unit, the detection unit (detection unit on the peripheral side) closer to the injection point of the fluorescent dye is referred to as the first detection unit 12, and from the injection point. A detection unit (central detection unit) positioned farther away is referred to as a second detection unit 13. The first detection unit 12 includes a first line LED 12a and a first line sensor 12b, and the second detection unit 13 includes a second line LED 13a and a second line sensor 13b. The line LEDs 12a and 13a are illumination means for applying excitation light to the fluorescent dye injected into the lymphatic vessel, and are lit during measurement. On the other hand, the line sensors 12b and 13b are light receiving means for detecting the fluorescence emitted from the fluorescent dye that has received the excitation light and outputting a signal indicating the detected fluorescence intensity to the fluorescence intensity meter 20.

  The first line LED 12a and the first line sensor 12b are linearly (continuously) provided along the entire edge of the one edge extending along the width direction of the manchette 10 while being adjacent to each other. ing. The second line LED 13a and the second line sensor 13b are provided linearly (continuously) along the entire edge of the other edge extending along the width direction of the manchette 10 while being adjacent to each other. ing. Therefore, when the manchette 10 is wound around the arm or leg, the first detection unit 12 and the second detection unit 13 surround the arm or leg. It can be said that the width direction of the manchette 10 is a direction orthogonal to the insertion direction of the arms or legs.

  The wavelength of the excitation light emitted from the line LEDs 12a and 13a is different from the wavelength of the fluorescence emitted from the fluorescent dye that has received the excitation light and detected by the line sensors 12b and 13b. For example, if the wavelength of excitation light applied to indocyanine green is 805 nm, the wavelength of fluorescence from indocyanine green is 845 nm. Of course, the wavelength of the excitation light emitted from the line LEDs 12a and 13a and the wavelength of the fluorescence detected by the line sensors 12b and 13b are not limited to the above, and may be arbitrarily set according to the type of the fluorescent dye.

  The fluorescence intensity meter 20 is electrically connected to the two line sensors 12b and 13b of the manchette 10 and extends along the width direction of the manchette 10 based on signals input from the line sensors 12b and 13b. It is a device that displays the intensity of fluorescence at one edge. Thereby, the user of the lymph pressure measurement system 1 can visually know whether or not the fluorescent dye has passed through the two portions surrounded by the line sensors 12b and 13b.

  The fluorescence intensity meter 20 determines whether or not the fluorescent dye has passed through the two parts surrounded by the line sensors 12b and 13b based on the input signal, and the fluorescent dye is the part of each of the two parts. When the signal first passes, a passage signal indicating the passage is output to the pressure measuring device 30. Therefore, the passage signal is output twice from the fluorescence intensity meter 20 in one measurement. The first passage signal means that the fluorescent dye has passed under the first line sensor 12b located closer to the injection point of the fluorescent dye (peripheral side). On the other hand, the second pass signal passes through the portion where the fluorescent dye is covered with the manchette 10 and passes under the second line sensor 13b located farther from the injection point (central side of the human body). Means that

  The fluorescence intensity meter 20 may determine the passage of the fluorescent dye based on the magnitude of the change in the fluorescence intensity, or the fluorescence intensity meter 20 may detect the fluorescence when the detected intensity is equal to or higher than a threshold value held in advance. It may be determined that the dye has passed. Of course, the specific determination method is not limited to these.

  The pressure measuring device 30 is a device that measures the pressure of the manchette 10. The pressure measuring device 30 is connected to the manchette 10 via a pipe for supplying or sucking air to or from the manchette 10 and is electrically connected to the fluorescence intensity meter 20. The pressure measuring device 30 includes a pressure adjusting unit 31 and a measuring unit 32 as functional components.

  Note that a lymphometer may be used as the pressure measuring device 30, or a sphygmomanometer may be used. Further, a measuring device that can handle both lymphatic pressure measurement and blood pressure measurement may be used as the pressure measuring device 30.

  The pressure adjusting unit 31 is a means for adjusting the pressure of the manchette 10. The pressure adjusting unit 31 starts to send air into the air bag in the manchette 10 when the first passage signal is input from the fluorescence intensity meter 20, and to such an extent that the lymph flow in the living body observation unit is blocked (for example, 60 mmHg). The manchette 10 is pressurized. Subsequently, the pressure adjusting unit 31 depressurizes the manchette 10 by a predetermined amount (for example, by 1 mmHg, by 5 mmHg, by 10 mmHg, etc.) at a predetermined timing until the second passage signal is input.

  The measuring unit 32 is a means for measuring the pressure of the manchette 10. The measurement unit 32 starts pressure measurement when the first passage signal is input from the fluorescence intensity meter 20. Thereafter, when the second passage signal is input, the measurement unit 32 records the pressure of the manchette 10 at that time as the lymph pressure, and outputs the lymph pressure data to the lymph age estimation system 2.

  The procedure of lymphatic pressure measurement by the lymphatic pressure measurement system 1 will be described with reference to FIG. First, the manchette 10 is attached to a location (living observation unit) where lymph pressure is to be measured, and the two line LEDs 12a and 13a are turned on in order to detect the fluorescent dye. Next, as shown in FIG. 3A, the fluorescent dye F is injected into the lymphatic vessel of the measurement subject. In this example, the fluorescent dye F is injected near the instep of the foot by subcutaneous injection. Thereafter, as shown in FIG. 3B, the fluorescent dye F starts to move from the injection point to the human body through the lymphatic vessel.

  After that, as shown in FIG. 3C, when the fluorescent dye F reaches one end of the manchette 10 (an edge closer to the injection point of the fluorescent dye), the fluorescent dye F emits excitation light from the first line LED 12a. The fluorescence is received and emitted, and the first line sensor 12b detects the fluorescence. And according to this detection, the pressure adjustment part 31 in the pressure measurement apparatus 30 pressurizes the manchette 10, and interrupts the lymph flow of a biological observation part. Therefore, the state shown in FIG. 3C is maintained. At this time, the measurement unit 32 starts measuring the pressure.

  Thereafter, the pressure adjusting unit 31 gradually depressurizes the manchette 10. When the autonomic contraction pressure of the lymphatic vessel exceeds the pressure of the manchette 10 by this decompression process, the fluorescent dye F begins to move toward the center (resumption of lymph flow), at least a part of which is shown in FIG. To the other end of the manchette 10 (the edge farther from the injection point of the fluorescent dye). At this time, the fluorescent dye F that has reached the other end emits fluorescence upon receiving excitation light from the second line LED 13a, and the second line sensor 13b detects the fluorescence. In response to this detection, the measurement unit 32 of the pressure measuring device 30 measures the pressure of the manchette 10 at that time as lymphatic pressure. Then, the measurement unit 32 outputs the measured lymph pressure to the lymph age estimation system 2. This completes the measurement of lymphatic pressure. After that, the fluorescent dye F further proceeds toward the central part of the human body as shown in FIG.

  Next, the function and configuration of the lymph age estimation system 2 will be described.

  The lymph age estimation system 2 has a hardware configuration as shown in FIG. 4, for example. That is, the lymph age estimation system 2 includes a CPU 201 that executes an operating system, application programs, and the like, a main storage unit 202 that includes a ROM and a RAM, an auxiliary storage unit 203 that includes a flash memory and a hard disk, and data The communication control unit 204 performs communication, an output device 205 such as a monitor and a printer, and an input device 206 such as a keyboard and a mouse.

  Functional components to be described later read predetermined software on the CPU 201 and the main storage unit 202, operate the communication control unit 204, the output device 205, and the input device 206 under the control of the CPU 201, This is realized by reading / writing data from / to 202 or the auxiliary storage unit 203. Data and databases necessary for processing are stored in the main storage unit 202 and the auxiliary storage unit 203.

  As shown in FIG. 1, the lymph age estimation system 2 includes a reception unit (reception unit) 41, a calculation unit (calculation unit) 42, and a display unit 43 as functional components.

  The accepting unit 41 is means for accepting lymph pressure data of the subject input from the lymph pressure measuring system 1. The accepting unit 41 outputs the data to the calculating unit 42.

  The calculating unit 42 is a unit that calculates the estimated lymph age of the subject from the lymph pressure data input from the receiving unit 41. The calculation unit 42 holds in advance a function indicating the relationship between the actual age of the person and the lymph pressure, and uses this function to obtain the estimated lymph age.

  The function used by the calculation unit 42 is represented by y = f (x), where the actual age of the person is the independent variable x and the lymph pressure is the dependent variable y. The graph of this function f (x) can be called an “age-lymph pressure curve”. The function f (x) is derived based on a measurement of lymph pressure in the extremities of a certain number of healthy persons in a wide age group. Specifically, the average value and standard deviation of lymphatic pressure are calculated for each predetermined age group based on the measurement results, and the average value and standard deviation of each age group are calculated using a predetermined program (for example, a spreadsheet application program). From this, the function f (x) can be obtained. The function f (x) may be defined in the code of the lymph age estimation program, or may be defined in an external file prepared independently of the program code. In any case, the calculation unit 42 reads this function f (x), and calculates the estimated lymph age by substituting the input lymph pressure into this function.

The function f (x) may be used for both men and women, or may be defined for each gender. In the present embodiment, a function commonly used by both men and women is particularly called f _c (x), a function for men is called f _m (x), and a function for women is called f _f (x). In the case of using different functions according to sex, the calculation unit 42 uses data indicating the sex of the subject in addition to the measured value of lymphatic pressure. In addition, the aspect which acquires the data of sex is not limited, For example, the calculation part 42 may use the value input via the input device 206, and may use the value read from the predetermined memory | storage device. .

  An example of the function f (x) is shown below. Some of the functions shown below are based on the results of measuring the lymph pressure of both legs with the consent of about 300 healthy volunteers aged 20-91 years. The total number of samples by gender was 380 each. And the average value and standard deviation of seven age groups (20s, 30s,..., 70s, and 80s or more) were obtained from the measurement results. The bar graphs in Table 1 and FIG. 5 are gender mixed statistics, the bar graphs in Table 2 and FIG. 6 are statistics for men, and the bar graphs in Table 3 and FIG. 7 are statistics for women. The vertical axis and the horizontal axis of each graph are lymphatic pressure and age (actual age), respectively.

The following quadratic functions f _c (x), f _m (x), and f _f (x) were obtained from the statistics shown in Tables 1 to 3 above. The graphs of these quartic functions are shown by solid lines in FIGS. “E-07” indicates 10 ⁻⁷ , and “E-06” indicates 10 ⁻⁶ . The square value of the correlation coefficient (R-square value) was 0.1205 for f _c (x), 0.1096 for f _m (x), and 0.1492 for f _f (x).

y = f _c (x)
= 5E-07x ⁴ -0.0003x ³ + 0.0478x ²
-2.746x + 82.347
y = f _m (x)
= 1E-06x ⁴ -0.0005x ³ + 0.0676x ²
-3.5248x + 91.612
y = f _f (x)
= 5E-06x ⁴ -0.0013x ³ + 0.1192x ²
-4.9462x + 106.37

Although there are individual differences in the lymph pressure collected as a sample, it can be seen from the above tables that the lymph pressure decreases with age, that is, the pump pressure of the lymphatic vessels ejecting the lymph decreases with age. Reflecting such a tendency, the function f (x) basically becomes a decreasing function in the range of the assumed age of the person (independent variable x). In the function f _m (x), there exists an inflection point in the graph of FIG. 6, which can be said to be a range of errors accompanying variations in measured values. However, an inflection point of the function f (x) may exist within the assumed range of x. That is, the value y may increase in a partial section of the variable x.

The function f (x) may not be a quartic function, and the calculation unit 42 may use f (x) defined as an nth order function (n ≧ 1). For example, the functions f _c (x), f _m (x), and f _f (x) can be represented by a linear function, a quadratic function, or a cubic function from the statistics in Tables 1 to 3 above. Of course, the function f (x) may be defined by a polynomial of 5th order or higher.

When defined by a linear function, the functions f _c (x), f _m (x), and f _f (x) are expressed as follows. The graphs of these linear functions are shown by alternate long and short dash lines in FIGS. In this case, the R-squared value was 0.1058 for f _c (x), 0.0916 for f _m (x), and 0.1406 for f _f (x).
y = f _c (x) = − 0.2812x + 44.466
y = f _m (x) = − 0.2279x + 43.999
y = f _f (x) = − 0.3873x + 48.456

When defined by a quadratic function, the functions f _c (x), f _m (x), and f _f (x) are expressed as follows. The graphs of these quadratic functions are shown by broken lines in FIGS. In this case, the R-squared value was 0.1058 for f _c (x), 0.1003 for f _m (x), and 0.141 for f _f (x).
y = f _c (x) = 0.2048x ² −0.7682x + 54.842
y = f _m (x) = 0.007x ² −0.7091x + 52.998
y = f _f (x) = 0.0011x ² −0.4993x + 50.866

When defined by a cubic function, the functions f _c (x), f _m (x), and f _f (x) are expressed as follows. Since these cubic function graphs almost overlap with the above-described quartic function graphs, see the solid lines in FIGS. 5 to 7 for the cubic function graphs. In this case, the R-squared value is 0.1205 for f _c (x), 0.1096 for f _m (x), and 0.1486 for f _f (x). Same or nearly the same as the case.
y = f _c (x)
= −0.0002x ³ + 0.0396x ² −2.4855x + 79.521
y = f _m (x)
= −0.0003x ³ + 0.0493x ² −2.9426x + 85.096
y = f _f (x)
= −0.0003x ³ + 0.0445x ² −2.6609x + 81.218

The functions f _c (x), f _m (x), and f _f (x) may be represented by exponential functions. For example, the following functions f _c (x), f _m (x), and f _f (x) can be obtained from Tables 1 to 3 above. Graphs of these exponential functions are shown in FIGS.
y = f _c (x) = 49.265e ^{−0.022x
_{y = f m (x) =}} 42.656e -0.016x
y = f _f (x) = 72.878e ^−0.032x

The functions f _c (x), f _m (x), and f _f (x) may be represented as a sum of a plurality of arbitrary functions by a fitting method. For example, the functions f _c (x), f _m (x), and f _f (x) may be indicated by the sum of a plurality of exponential functions, or may be indicated by the sum of a plurality of n-order functions. The sum may be an exponential function and an n-order function.

When the lymphatic pressure measurement value is input, the calculation unit 42 selects the function y = f (x) in consideration of the input of gender data. Specifically, the calculation unit 42 selects the function f _c (x) when gender data is not input, and functions g _m (x) according to the data when gender data is input. Alternatively, the function f _f (x) is selected. Then, the calculation unit 42 obtains the age x by substituting the measured value into the variable y of the selected function. Then, the calculation unit 42 outputs the obtained age x to the display unit 43 as the estimated lymph age.

  The display unit 43 is means for displaying the estimated lymph age input from the calculation unit 42 on the output device 205 (monitor). The display method of the estimated lymph age is not limited. For example, the display unit 43 may display the estimated lymph age as it is, or may display it as an age group such as 30s or 50s. Moreover, the display part 43 may show an estimated lymph age more visually by drawing an estimation result by arbitrary symbols and figures on a graph as shown in FIGS.

  The method for outputting the estimated lymph age is not limited to the above. For example, the estimated lymph age may be output to a printer, transmitted to another information processing apparatus, or stored in a predetermined storage device.

  Next, the operation of the lymph age estimation system 2 will be described using FIG. 11 and the lymph age estimation method according to the present embodiment will be described.

First, the reception part 41 receives the measured value of the lymph pressure input from the lymph pressure measurement system 1 (step S11, reception step). Subsequently, the calculation unit 42 selects a function y = f (x) used for the calculation (step S12). For example, the calculation unit 42 selects one of the above f _c (x), f _m (x), and f _f (x). Subsequently, the calculation unit 42 obtains the estimated lymph age of the subject by substituting the measured value of the lymph pressure into the selected function y = f (x) (step S13, calculation step). Finally, the display unit 43 displays the estimated lymph age (step S14). Thus, the subject can know his / her estimation result.

  Next, a lymph age estimation program P1 for causing a computer to function as the lymph age estimation system 2 will be described with reference to FIG.

  The lymph age estimation program P1 includes a main module P10, a reception module P11, a calculation module P12, and a display module P13.

  The main module P10 is a part that comprehensively controls the lymph age estimation function. The functions realized by executing the reception module P11, the calculation module P12, and the display module P13 are the same as the functions of the reception unit 41, the calculation unit 42, and the display unit 43, respectively.

  The lymph age estimation program P1 is provided after being fixedly recorded on a tangible recording medium such as a CD-ROM, DVD-ROM, or semiconductor memory. The lymph age estimation program P1 may be provided via a communication network as a data signal superimposed on a carrier wave.

  As described above, according to the present embodiment, the function y = f (x) indicating the relationship between the actual age of the person and the lymph pressure is prepared in advance, and the measured value of the lymph pressure is substituted into this function. Thus, the estimated lymph age of the subject is calculated. Thereby, a person's lymph age can be estimated easily. Further, when the actual age and the estimated lymph age of the subject are different from each other, it is possible to determine the youngness of the subject's lymph, the degree of aging, and the like by comparing with the average value of the age group.

  Moreover, according to this embodiment, by defining the relationship between age and lymphatic pressure for each gender, the lymph age of the subject can be estimated in consideration of gender differences.

  The present invention has been described in detail based on the embodiments. However, the present invention is not limited to the above embodiment. The present invention can be variously modified without departing from the gist thereof.

  The method for measuring the lymph pressure input to the lymph age estimation system is not limited. For example, lymphatic pressure may be measured using a lymphatic scintigram that uses a radioisotope instead of the fluorescent dye described above. Further, the method for acquiring the measured value of lymphatic pressure is not limited. For example, the lymph age estimation system does not directly acquire the measurement data from the lymph pressure measurement system, but reads the lymph pressure measurement data once stored in a predetermined database and substitutes the read data into a function for estimation. The lymph age may be determined.

  The specific configuration of the lymph age estimation system is not limited. For example, the lymph pressure measurement system 1 and the lymph age estimation system 2 in the above embodiment may be integrated into one apparatus.

  DESCRIPTION OF SYMBOLS 1 ... Lymphatic pressure measurement system, 2 ... Lymph age estimation system, 10 ... Manchette, 12 ... 1st detection part, 13 ... 2nd detection part, 20 ... Fluorescence intensity meter, 30 ... Pressure measuring device, 31 ... Pressure adjustment part, 32 ... Measuring unit, 41 ... Reception unit (receiving unit), 42 ... Calculation unit (calculating unit), 43 ... Display unit, P1 ... Lymph age estimation program, P10 ... Main module, P11 ... Reception module, P12 ... Calculation module, P13: Display module.

Claims (8)

A receiving means for receiving a measured value of the subject's lymphatic pressure;
A calculation means for calculating the estimated lymph age of the subject by substituting the measurement value received by the reception means into a function indicating the relationship between the age of the person and lymphatic pressure,
The function is represented by y = f (x), where the age is an independent variable x and the lymphatic pressure is a dependent variable y, and is a decreasing function in the range of the assumed independent variable x.
Lymph age estimation system. The function is an n-order function;
The lymph age estimation system according to claim 1 . n is 3 or more,
The lymph age estimation system according to claim 2 . The function is an exponential function;
The lymph age estimation system according to claim 1 . The function is indicated by a sum of a plurality of functions;
The lymph age estimation system according to claim 1 . The function includes a first function for calculating an estimated lymph age of a male and a second function for calculating an estimated lymph age of a female;
The calculation means selects a function corresponding to the data indicating the sex of the subject from the first and second functions, and substitutes the measured value for the selected function, thereby calculating the estimated lymph age of the subject. calculate,
The lymph age estimation system according to any one of claims 1 to 5 . A lymph age estimation method executed by a computer,
An accepting step for accepting a measured value of the subject's lymphatic pressure;
A function representing the relationship between human age and lymphatic pressure, by substituting the measured values accepted in the accepting step, seen including a calculation step of calculating an estimated lymph age of the subject,
The function is represented by y = f (x), where the age is an independent variable x and the lymphatic pressure is a dependent variable y, and is a decreasing function in the range of the assumed independent variable x.
Lymph age estimation method. On the computer,
A receiving means for receiving a measured value of the subject's lymphatic pressure;
By substituting the measured value received by the receiving means into a function indicating the relationship between the age of the person and lymphatic pressure, the calculation means for calculating the estimated lymph age of the subject is executed ,
The function is represented by y = f (x), where the age is an independent variable x and the lymphatic pressure is a dependent variable y, and is a decreasing function in the range of the assumed independent variable x.
Lymph age estimation program.

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