JP5753344B2 - Oral composition - Google Patents

Description

  The present invention relates to a liquid or liquid oral composition that is transparent and excellent in flavor. More specifically, the present invention relates to an oral composition containing l-menthol and a nonionic surfactant, and a liquid or liquid oral composition containing 1,3-propanediol and having a good flavor.

  Since the liquid or liquid oral composition is used by retaining the composition in the oral cavity for a certain period of time without diluting the composition, there is a feature that the taste and smell of the composition itself can be felt strongly. Therefore, when developing a liquid or liquid oral composition, a technique higher than that of other oral compositions is required in order to achieve a highly palatable flavor. Generally, l-menthol is blended in a liquid or liquid oral composition for the purpose of improving a refreshing feeling and flavor and improving palatability. Since l-menthol does not dissolve in water, a surfactant and a polyhydric alcohol are usually blended together. However, when these surfactants and polyhydric alcohols are blended, the composition becomes unsatisfactory, the raw material odor is strong and the flavor is prevented, and the refreshing flavor is impaired.

  In order to solve this problem, a technology for providing a liquid oral composition that does not have a taste, stickiness, or irritation derived from a nonionic surfactant and gives a good refreshing feeling by blending a specific menthol derivative (Patent Document 1) In addition to a specific amount of nonionic surfactant, by adding a small amount of anionic surfactant and a large amount of sugar alcohol, the fragrance component was stably dissolved, and the irritation and taste of the surfactant were suppressed. A technique for providing a liquid oral composition (Patent Document 2), a sugar fatty acid ester, a carboxylic acid ester compound having 12 to 18 carbon atoms and a specific terpene compound, solubilizing menthol stably and having a good flavor A technology that provides a composition for liquid oral cavity with less irritation (Patent Document 3), erythritol, nonionic surfactant having specific HLB and ethanol In Rukoto, such techniques to provide oral compositions of bitter or impoverished liquid or liquid (Patent Document 4) have been proposed as to dissolve the menthol stable. However, a sufficient effect has not yet been obtained, and development of a more effective technique has been desired.

JP-A-8-165228 Japanese Patent Application Laid-Open No. 2005-265353 JP 2007-15959 A JP 2007-217363 A

  The present invention provides a transparent, liquid or liquid oral composition characterized by reducing the off-flavor and irritation derived from nonionic surfactants and obtaining a refreshing feeling with a good flavor. Objective.

  As a result of intensive investigations to solve the above problems, the present inventors have surprisingly found that by adding l-menthol and 1,3-propanediol, the taste and irritation caused by the nonionic surfactant As a result, the present inventors have found that it is possible to obtain a refreshing feeling with a good flavor and a good flavor.

That is, the present invention includes the following aspects.
Item 1. A liquid or liquid oral composition characterized in that 1,3-propanediol is blended in a composition blended with l-menthol and a nonionic surfactant.
Item 2. Item 2. The liquid or liquid oral composition according to Item 1, wherein the nonionic surfactant is polyoxyethylene hydrogenated castor oil.
Item 3. Item 3. The liquid or liquid oral composition according to Item 1 or 2, wherein the amount of l-menthol is 0.001 to 0.5% by mass.
Item 4. The liquid or liquid oral composition according to any one of Items 1 to 3, wherein the amount of 1,3-propanediol is 1 to 10% by mass.

  The liquid or liquid oral composition of the present invention is transparent and can reduce the off-flavor and irritation derived from the nonionic surfactant, and can give a refreshing feeling with a good flavor.

  Hereinafter, the present invention will be described in more detail.

  1,3-propanediol used in the present invention is a colorless oily liquid, is also called trimethylene glycol and 1,3-dihydroxypropane, and is widely used in the production of polyesters. Although a compounding quantity is not specifically limited, Generally 0.1-40 mass% can be mix | blended, 1-20 mass% is preferable and 1-10 mass% is more preferable. Moreover, when using together with a xylitol or glycerol, 1-3 mass% is the most preferable.

  The l-menthol used in the present invention is not particularly limited as long as l-menthol contains, for example, l-menthol obtained by chemical synthesis, naturally-derived l-menthol produced from a plant, and dl form Or a mixture of essential oil components can also be used. The raw materials containing these l-menthols can be blended alone or in appropriate combination of two or more, and the blending amount is not particularly limited, but is 0.001 to 0.5% by mass, and among them the flavor From this point, 0.005 to 0.3 mass% is preferable, and 0.01 to 0.2 mass% is most preferable.

  The nonionic surfactant used in the present invention is not limited as long as it can be usually used in cosmetics and pharmaceuticals. For example, polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, polyhydric alcohol fatty acid ester, glycerin fatty acid Ester, polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester, fatty acid alkanolamide, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, poly Examples thereof include oxyethylene polyoxypropylene alkyl ether. Among these, polyoxyethylene hydrogenated castor oil is preferable. As polyoxyethylene hydrogenated castor oil, compounds having an average degree of polymerization of ethylene oxide of 5, 10, 20, 30, 40, 50, 60, 80, 100 mol are commercially available. Among these, polyoxyethylene (40 ) Hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil is preferred. These nonionic surfactants can be blended alone or in appropriate combination of two or more, and the blending amount thereof is not particularly limited, but is 0.01 to 5% by mass, and 0.05 to 2% by mass. preferable.

  In addition to the above components, other components can be blended in the liquid or liquid oral composition of the present invention. For example, surfactants other than nonionic surfactants, wetting agents, sweeteners, flavoring agents, medicinal agents, thickeners, pH adjusters, coloring agents, preservatives, etc. are appropriately selected within a range that does not impair the effects of the present invention. Can be blended.

  Examples of surfactants other than nonionic surfactants include sodium lauryl sulfate, polyoxyethylene sodium lauryl sulfate, sodium myristyl sulfate, sodium N-palmitoyl glutamate, sodium sarcosine, polyoxyethylene alkyl (12-16) ether phosphate, and the like. Anionic surfactants such as N-lauryldiaminoethylglycine, N-myristyldiethylglycine, and other N-alkyldiaminoethylglycines, N-alkyl-N-carboxymethylammonium betaines, and lauryldimethylaminoacetic acid betaines Amphoteric surfactants. These surfactants can be blended alone or in appropriate combination of two or more.

  Examples of the wetting agent include ethanol, glycerin, sorbit, ethylene glycol, propylene glycol, 1,3-butylene glycol, isoprene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, and palatinit. These wetting agents can be blended alone or in appropriate combination of two or more.

  Examples of the sweetener include saccharin sodium, stevioside, glycyrrhizin, xylit, sucralose, xylitol, palatinose, palatinit, erythritol, maltitol and the like. These sweeteners can be blended alone or in appropriate combination of two or more.

  As a flavoring agent, carboxylic acid, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronell, α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineol, linalool, ethyl linalool, Examples include fragrances such as thymol. These flavoring agents can be blended in a proportion of 0.001 to 1% by mass, preferably 0.01 to 0.5% by mass, alone or in combination of two or more.

  Medicinal agents include, for example, cationic fungicides such as cetylpyridinium chloride, chlorhexidine hydrochloride, benzethonium chloride, amphoteric fungicides such as dodecyldiaminoethylglycine, nonionic fungicides such as triclosan and isopropylmethylphenol, dextranase, Anti-inflammatory agents such as amylase, protease, mutanase, lysozyme, lytic enzyme (lytechenzyme), tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyl allantoin, dihydrocholesterol, glycyrrhizic acid, glycyrrhetinic acid, thiamines, riboflavins, Pyridoxine, vitamin B12, folic acid, niacin, biotin, pantothenic acid, vitamin C, vitamin A, vitamin D, vitamin E, vitamin K, etc. Glutamic acids, other, glycerophosphate, chlorophyll, sodium chloride and the like, can be blended in combination alone or in combination.

  As thickeners, cellulose compounds such as hydroxyethylcellulose, carboxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, cation-modified hydroxyethylcellulose, natural gums such as glucomannan, tara gum, guar gum, locust bean gum, tamarind seed gum, In addition, xanthan gum, pullulan, gellan gum and the like can be mentioned, and these can be blended alone or in combination of two or more.

  The liquid or liquid oral composition of the present invention preferably has a viscosity of 150 mPa · s or less. More preferably, it is 100 mPa * s or less, Most preferably, it is 35 mPa * s or less. If it exceeds 150 mPa · s, the usability may be deteriorated, which is not preferable. The viscosity of the composition is measured using a conical plate type rotational viscometer (E type viscometer) under the conditions of 25 ° C., 20 rpm and 60 seconds.

  The liquid or liquid oral composition of the present invention is preferably transparent in the composition. The transparency of the composition was measured visually or with a color difference meter. There is no restriction | limiting in particular as a color difference meter to be used, A commercially available color difference meter or a spectrophotometer can be used. For example, measurement is performed using a spectrophotometer (UV-2450) manufactured by Shimadzu Corporation, and analysis of the measured value is performed using UVPC OPTIONAL COLOR ANALYSIS SOFTWARE, etc., so that whiteness (WB value, JIS standard), yellowness (YI) Value). The whiteness is preferably 90 or more, more preferably 95 or more. The yellowness is preferably 6 or less, more preferably 3 or less. In addition, the transparent stability over time was measured by measuring the average particle size (hydrodynamic diameter) of the composition. The measurement of the average particle diameter can be obtained by analyzing by the cumulant method from the autocorrelation function obtained by the photon correlation method. For example, it can be measured as a Z-averag size value using a Zetasizer Nano ZS (Malvern Instruments Ltd.). The average particle size is preferably 50 nm or less, more preferably 40 nm or less.

  The liquid or liquid oral composition of the present invention can be applied as liquid dentifrice, water dentifrice, mouthwash, mouth spray, mouthwash and the like.

  Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. In addition, the compounding quantity in a sentence shows the mass% as long as there is no special regulation.

Evaluation of flavor The evaluation of flavor was performed according to the following procedure. Absolute evaluations based on four grades were carried out on three specialized panels for Examples 1 to 7 and Comparative Examples 1 to 6 produced by a conventional method. In the test, 10 ml of each composition was taken and contained in the mouth for about 20 seconds. The obtained results were tabulated and the average score was calculated for each evaluation item. The evaluation results were performed according to the following criteria.
Score 4: Very good / not at all
3: Good / Don't feel
2: Bad / feel
1: Very bad / feels pretty

Evaluation criteria ◎: 3 or more
○: 3 to 2
×: Less than 2

Overall evaluation ◎: Evaluation of all flavors is ◎
○: Is the flavor evaluation ◎?
×: Other than above

Transparency evaluation (visual judgment)
The transparency was evaluated visually. Each sample subjected to flavor evaluation was filled into a cylindrical sample bottle having a diameter of about 5 cm, and the transparency when the contents were observed from the side of the bottle was evaluated. The case where it was recognized as transparent was marked with ◯, and the others were marked with ×.

Transparency evaluation (color difference meter measurement)
Transparency evaluation by color difference measurement was performed according to the following procedure. Each sample subjected to flavor evaluation was measured with a spectrophotometer (UV-2450) manufactured by Shimadzu Corporation using an X ₁₀ Y ₁₀ Z ₁₀ color system based on a 10 ° field of view, and the whiteness (WB value, JIS). Standard) and yellowness (YI value) were evaluated. The measurement conditions were a glass cell, the measurement mode was transmittance, the viewing angle was 10 ° C., and the analysis was performed with UVPC OPTIONAL COLOR ANALYSIS SOFTWARE.
Evaluation criteria ○: WB 90 or more, less than YI 6
X: Less than WB 90, YI 6 or more

Evaluation of transparency stability The transparency stability was evaluated according to the following procedure. Each sample subjected to flavor evaluation was measured using a Z-average size value measured by a Zetasizer Nano ZS (Malvern Instruments Ltd.) and a Zetasizer NanoZS. For the measurement, a disposable cuvette cell was used, and the measurement temperature was 25 ° C. The transparent stability was evaluated according to the following criteria.

Evaluation criteria ○: Less than 50
×: 50 or more

  The obtained results are shown in Tables 1 and 2.

  As shown in Table 1 and Table 2, it was found that the liquid or liquid oral composition containing 1,3-propanediol showed an excellent flavor and maintained high transparency. On the other hand, 1,2-propanediol, 1,3-butanediol and the like, which are similar compounds, could not obtain the same effect.

  Below, the formulation example of the liquid or liquid oral composition which concerns on this invention is shown. Unless otherwise specified, the blending amount represents mass%.

Formulation Example 1
A liquid dentifrice was prepared according to a conventional method.
Ingredients Amount
Glycerin 10.0
1,3-propanediol 3.0
l-Menthol 0.05
Polyoxyethylene (60E.O.) hydrogenated castor oil 0.2
Cetylpyridinium chloride 0.05
Tranexamic acid 0.05
Citric acid 0.01
Trisodium citrate 0.1
Methyl paraoxybenzoate 0.1
Fragrance 0.05
Saccharin sodium 0.02
Purified water balance
Total 100.0

Formulation Example 2
A liquid dentifrice was prepared according to a conventional method.
Ingredients Amount
Glycerin 7.0
1,3-propanediol 5.0
l-Menthol 0.1
Polyoxyethylene (40E.O.) hydrogenated castor oil 0.4
Tocopherol acetate 0.02
Citric acid 0.01
Trisodium citrate 0.1
Sodium benzoate 0.2
Fragrance 0.1
Saccharin sodium 0.02
Purified water balance
Total 100.0

Formulation Example 3
A mouthwash was prepared according to a conventional method.
Ingredients Amount
Xylitol 3.0
1,3-propanediol 7.0
l-Menthol 0.05
Polyoxyethylene (60E.O.) hydrogenated castor oil 0.4
Isopropyl methylphenol 0.05
Citric acid 0.01
Trisodium citrate 0.1
Fragrance 0.05
Saccharin sodium 0.02
Purified water balance
Total 100.0

Formulation Example 4
A mouthwash was prepared according to a conventional method.
Ingredients Amount
Glycerin 15.0
1,3-propanediol 1.0
l-Menthol 0.1
Sucrose laurate 0.3
Isopropyl methylphenol 0.05
Citric acid 0.01
Trisodium citrate 0.1
Sodium benzoate 0.2
Fragrance 0.1
Saccharin sodium 0.02
Purified water balance
Total 100.0

Formulation Example 5
A mouse spray was prepared according to a conventional method.
Ingredients Amount
Ethanol 35.0
Glycerin 10.0
1,3-propanediol 3.0
l-Menthol 0.5
Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0
Cetylpyridinium chloride 0.05
Citric acid 0.1
Trisodium citrate 0.1
Fragrance 0.9
Saccharin sodium 0.1
Purified water balance
Total 100.0

Formulation Example 6
A liquid dentifrice was prepared according to a conventional method.
Ingredients Amount
Hydroxyethyl cellulose 1.0
Concentrated glycerin 20.0
Ethanol 10.0
1,3-propanediol 3.0
l-Menthol 0.3
Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0
Sodium fluoride 0.2
Cetylpyridinium chloride 0.05
Methyl paraoxybenzoate 0.1
Fragrance 0.3
Saccharin sodium 0.2
Purified water balance
Total 100.0

Claims (4)

In a composition that does not contain ethanol and contains polyoxyethylene (60) hydrogenated castor oil, l-menthol, and a fragrance, 0.15 to 0.40% by mass of polyoxyethylene (60) hydrogenated castor oil, , 3-Propanediol 3-10% by mass blended liquid or liquid oral composition characterized by the above . The liquid or liquid oral composition according to claim 1, wherein the amount of l-menthol is 0.01 to 0.2% by mass. The liquid or liquid oral composition according to any one of claims 1 and 2, wherein the viscosity of the composition is 35 mPa · s or less. The liquid or liquid according to any one of claims 1 to 3, wherein the degree of transparency of the composition is a whiteness (WB value) of 90 or more and a yellowness (YI value) of 6 or less. Oral composition.