JP5741087B2 - Blood pressure information measuring device - Google Patents

Description

  The present invention relates to a blood pressure information measuring device, and more particularly, to a blood pressure information measuring device that outputs an index representing the degree of hardening of an artery.

  The blood pressure in the aorta is a pressure directly applied to major organs such as the heart. Therefore, by measuring a blood pressure waveform representing the change in blood pressure (hereinafter referred to as an aortic blood pressure waveform), it is useful for predicting cerebrocardiovascular diseases such as stroke, myocardial infarction, and heart failure.

  The aortic blood pressure waveform is a composite wave including an ejection wave ejected from the heart and a reflected wave from each part in the artery including the iliac bifurcation.

  For example, as a method for determining arteriosclerosis degree, such as JP-T-2009-517140 (hereinafter referred to as Patent Document 1), the ejection wave and the reflected wave are separated from the aortic blood pressure waveform, and the amplitude difference, the amplitude ratio, A method using an index such as a difference in appearance time has been proposed.

  However, conventionally, the aortic blood pressure waveform had to be measured invasively by adopting a direct method using a catheter, and there was a problem that the burden on the patient was large.

  Therefore, as a method for solving this problem, for example, US Pat. No. 5,265,011 (hereinafter referred to as Patent Document 2), for example, measures a pressure pulse wave in the radial artery using a tonometry sensor, and aortic blood pressure by a transfer function method. A method for converting to a waveform is proposed.

Special table 2009-517140 US Pat. No. 5,265,011 Japanese Patent Laid-Open No. 10-94526

  Here, the applicant of the present application disclosed in Japanese Patent Application Laid-Open No. 10-94526 (hereinafter referred to as Patent Document 3) determines the transfer function used in the transfer function method according to the blood vessel characteristics of the person to be measured with high accuracy. A method for obtaining an aortic blood pressure waveform is disclosed. On the other hand, higher accuracy is required.

  The present invention has been made in view of such problems, and measures blood pressure information by measuring a peripheral artery to calculate an aortic blood pressure waveform with high accuracy and calculating an index representing the degree of hardening of the artery from the aortic blood pressure waveform. The object is to provide a device.

  In order to achieve the above object, according to one aspect of the present invention, the blood pressure information measurement device is a blood pressure information measurement device that non-invasively detects a blood pressure waveform in the aorta to calculate an arteriosclerosis index, and measures a subject Fluid bag for mounting on the site, compression means for compressing the distal side of the measurement site, and fluid mounted on the measurement site when the distal side of the measurement site is compressed by the compression means Computing means for calculating an arteriosclerosis index of the subject based on the pressure change of the bag. The computing means includes: a process for calculating a blood pressure value of the subject based on the pressure change; a process for calculating a pulse wave propagation time from the heart to the measurement site using the blood pressure value; Processing for calculating the blood reflection coefficient at the measurement site using a value representing the difference in blood vessel diameter from the side and a value representing the blood vessel hardness of the subject obtained from the pressure change, and a pulse wave propagation time, A process for calculating a transfer function using a reflection coefficient, a process for calculating a blood pressure waveform in the aorta by applying a transfer function to a pressure pulse wave obtained from a pressure change, and a subject's artery from the blood pressure waveform in the aorta And a process for calculating a curing index.

  Preferably, the calculating means is a value representing a difference in blood vessel diameter between the measurement site in the blood-feeding state and the peripheral side, and the difference between the compression force of the pressure means in the blood-feeding state and the calculated maximum blood pressure value of the subject. Is used.

  Preferably, the calculation means has a pulse wave amplitude, an AI (Augmentation Index) value that is a ratio of the amplitude of the ejection wave and the amplitude of the reflected wave, as a value representing the hardness of the blood vessel of the subject obtained from the pressure change, One of a Tr (Time of Reflection) value that is a difference in appearance time between the ejection wave and the reflected wave, and a value that represents a time difference between the appearance time of the peak of the ejection wave and the appearance time of the peak of the reflected wave The value of is used.

  Preferably, the blood pressure information measurement device further includes storage means for storing at least age and height as the subject's attribute information. The process of calculating the pulse wave propagation time includes the process of calculating the estimated value of the pulse wave propagation distance using the height of the subject, the estimated value of the pulse wave propagation speed from the calculated blood pressure value of the subject and the age of the subject, The process of calculating. In the processing for calculating the pulse wave propagation time, the calculation means calculates the pulse wave propagation time by dividing the estimated value of the pulse wave propagation distance by the estimated value of the pulse wave propagation velocity.

  Preferably, the calculation means further executes a process of calculating the arteriosclerosis index of the subject from the blood pressure waveform at the measurement site based on the pressure change. The blood pressure information measurement device further includes an output unit for outputting the calculated arteriosclerosis index, and the output unit calculates the arteriosclerosis index calculated from the blood pressure waveform in the aorta and the artery calculated from the blood pressure waveform at the measurement site. Outputs curing index.

  According to the present invention, an aortic blood pressure waveform can be obtained with high accuracy without imposing a burden on the measurement subject, and an index of the degree of arteriosclerosis based on the aortic blood pressure waveform can be calculated with higher accuracy.

It is a figure which shows the specific example of the external appearance of the blood-pressure information measuring apparatus (henceforth a measuring apparatus) concerning this Embodiment. (A) is a schematic cross section which shows the measurement attitude | position at the time of measuring blood-pressure information using a measuring apparatus, (B) is a figure which shows schematic structure of an armband. It is a block diagram which shows the specific example of a structure of a measuring apparatus. It is a figure explaining the positional relationship with the both air bags of the pressure sensor and pump of a compression air bag side, an exhaust valve, and the pressure sensor and 2 port valve of the air bag side for a pulse wave measurement. It is a block diagram which shows the specific example of a function structure of a measuring apparatus. It is a flowchart showing operation | movement in a measuring apparatus. It is a figure showing the internal pressure change of the air bag accompanying operation | movement of a measuring apparatus. It is a flowchart showing the operation | movement for calculating a transfer function. It is a figure showing the example of a display with a measuring device.

  Embodiments of the present invention will be described below with reference to the drawings. In the following description, the same parts and components are denoted by the same reference numerals. Their names and functions are also the same.

<Device configuration>
FIG. 1 is a diagram showing a specific example of an overview of a blood pressure information measurement device (hereinafter abbreviated as a measurement device) 1 according to the present embodiment.

  The measuring device 1 measures a biological value related to the blood pressure of the measurement subject and calculates blood pressure information. The blood pressure information includes a blood pressure value, a pulse wave waveform, a heart rate, etc., and a maximum blood pressure value, a minimum blood pressure value, a pulse rate, a pulse wave amplitude, an AI (Augmentation Index) value calculated from them, TR (Time of Reflection: appearance time difference) value and the like are included.

  Referring to FIG. 1, measuring apparatus 1 includes a base body 2 and an arm band 9 that is connected to the base body 2 by an air tube 8 and is attached to an upper arm that is a measurement site.

  A display unit 4 for displaying various information including measurement results and an operation unit 3 operated to give various instructions to the measuring device 1 are arranged on the front surface of the base 2. The operation unit 3 includes a switch 31 that is operated to turn on / off the power source and a switch 32 that is operated to instruct the start of measurement.

  FIG. 2A is a schematic cross-sectional view showing a measurement posture when measuring blood pressure information using the measuring device 1. With reference to FIG. 2 (A), when measuring the pulse wave using the measuring apparatus 1, the arm band 9 is wound around the upper arm 100 which is a measurement site. Measurement is started when the switch 32 is pressed in this state.

  Further, referring to FIG. 2 (A), arm band 9 includes air bag 13A and air bag 13B. The air bag 13A is used for measuring blood pressure, and the air bag 13B is used for measuring pulse waves. When the arm band 9 is wound around the upper arm 100 that is the measurement site, the air bag 13A covers the entire measurement site, and the air bag 13B is on the central side and is located between the air bag 13A and the upper arm 100. Preferably, a vibration isolating member for suppressing conduction of vibration between these air bags, such as a urethane sheet, is provided between the air bags 13A and 13B.

FIG. 2B is a diagram showing a schematic configuration of the armband 9.
Referring to FIG. 2 (B), air bag 13A and air bag 13B have substantially the same length in the longitudinal direction of arm band 9 and have at least a circumferential length of upper arm 100 or more. The ratio of the length in the width direction of the armband 9 between the air bag 13A and the air bag 13B is about 5: 1. Preferably, the size of the air bag 13A is the same as that of a normal blood pressure measurement air bag, and the size of the air bag 13B is about 20 mm × 220 mm.

FIG. 3 is a block diagram illustrating a specific example of the configuration of the measuring apparatus 1.
Referring to FIG. 3, pressure sensor 23A, pump 21 and exhaust valve 22 connected to air bag 13A by air tube 8 are connected to base body 2 of measuring apparatus 1, and air tube 8 is connected to air bag 13B. Pressure sensor 23B. The pressure sensor 23A, the pump 21, the exhaust valve 22, and the pressure sensor 23B are connected by an air tube 8 with a two-port valve 51 interposed therebetween.

  The 2-port valve 51 is connected to the drive circuit 53. The pressure sensors 23A and 23B are connected to amplifiers 28A and 28B, and the amplifiers 28A and 28B are connected to A / D converters 29A and 29B. The pump 21 is connected to the drive circuit 26, and the exhaust valve 22 is connected to the drive circuit 27.

  The drive circuit 26, the drive circuit 27, the A / D converters 29 </ b> A and 29 </ b> B, and the drive circuit 53 are connected to a CPU (Central Processing Unit) 40 for controlling the entire measuring apparatus 1. Further, the display unit 4, the operation unit 3, and the memory 5 are connected to the CPU 40.

  The memory 5 stores a control program executed by the CPU 40 and the like. Furthermore, the memory 5 also serves as a work area when the CPU 40 executes the program.

  The CPU 40 executes a predetermined program stored in the memory 5 based on the operation signal input from the operation unit 3 and outputs a control signal to the drive circuit 26, the drive circuit 27, and the drive circuit 53. The drive circuit 26, the drive circuit 27, and the drive circuit 53 drive the pump 21, the exhaust valve 22, and the 2-port valve 51 according to the control signals, respectively.

  The drive of the pump 21 is controlled by a drive circuit 26 according to a control signal from the CPU 40, and air is injected into the air bag 13A and / or the air bag 13B. The opening and closing of the exhaust valve 22 is controlled by a drive circuit 27 according to a control signal from the CPU 40, and the air in the air bag 13A and / or the air bag 13B is discharged.

  The two-port valve 51 is connected to the air bag 13A with the pressure sensor 23A, the pump 21, and the exhaust valve 22 in between, and the side connected to the air bag 13B with the pressure sensor 23B in between. And the opening and closing of each valve is controlled by a drive circuit 53 in accordance with a control signal from the CPU 40. When both valves are opened, the air bag 13A and the air bag 13B are connected by the air tube 8 to form one space. When one of the valves is closed, the air bag 13A and the air bag 13B form independent spaces.

  The pressure sensors 23A and 23B are capacitance type pressure sensors, and their capacitance values change due to changes in the internal pressure of the air bags 13A and 13B. Oscillation frequency signals corresponding to the capacitance values of the pressure sensors 23A and 23B are amplified to a predetermined frequency by the amplifiers 28A and 28B, converted into digital signals by the A / D converters 29A and 29B, and then input to the CPU 40.

  The CPU 40 executes a predetermined process based on the change in the internal pressure of the air bladders 13A and 13B obtained from the pressure sensors 23A and 23B, and controls the control signal to the drive circuit 26, the drive circuit 27, and the drive circuit 53 according to the result. Is output. Further, the CPU 40 calculates blood pressure information such as a blood pressure value and a pulse based on changes in the internal pressure of the air bags 13A and 13B obtained from the pressure sensor 23, and performs a process for displaying the measurement result on the display unit 4. Data for display and control signals are output to the display unit 4. Further, the CPU 40 performs a process for storing blood pressure information in the memory 5.

  FIG. 4 is a diagram for explaining the positional relationship of the pressure sensor 23A, the pump 21, the exhaust valve 22, the pressure sensor 23B, and the two-port valve 51 with the air bags 13A and 13B.

  Referring to FIG. 4, air bag 13A and air bag 13B are in contact with each other with a vibration preventing member such as a urethane sheet interposed therebetween, and air bag 13B is further covered with a cover such as a urethane nonwoven fabric.

  When the arm band 9 of the air bag 13A is wound around the measurement site, the air tube 8 is connected to the distal side, and the pressure sensor 23A, the pump 21, and the exhaust valve 22 are arranged in the vicinity thereof.

  When the armband 9 of the air bag 13B is wound around the measurement site, the air tube 8 is connected to the central side (heart side), and the pressure sensor 23B and the 2-port valve 51 are arranged in the vicinity thereof.

<Principle of the invention>
In order to obtain an aortic blood pressure waveform, for example, as disclosed in Patent Document 2 (US Pat. No. 5,265,011), a pressure pulse wave in the radial artery is measured using a tonometry sensor, and a transfer function method is used. A method for converting into an aortic blood pressure waveform has been proposed.

The transfer function H corresponding to the ratio between the aortic blood pressure waveform P1 (t) and the blood pressure pulse wave P2 (t) of the radial artery is the pulse wave propagation time T between the aorta and the radial artery, The applicant of the present application discloses that the following equation (1) is expressed using the time delay factor Δ between the osseous part and the radial artery part and the reflection coefficient Γ in the artery. Already disclosed in US Pat.
H = P1 (t) / P2 (t) = (1 + ΓΔ ² ) / (Δ + ΓΔ) Equation (1).

The delay factor Δ is expressed by the following equation (2) using the angular velocity ω.
Δ = e ^−jωT Equation (2).

The time delay factor Δ (= e ^−jωT ) between the aorta and the radial artery included in the above equation (1) representing the transfer function H and the reflection coefficient Γ within the artery are both unknown.

Here, since the pulse wave propagation time T is the time until the pulse wave leaving the heart reaches the measurement site, the estimated value of the pulse wave propagation distance (L_e) and the estimated value of the pulse wave propagation velocity (V_e) From the following equation (3),
T = L_e / V_e Formula (3).

In Expression (3), the estimated value (L_e) of the pulse wave propagation distance is an estimated value of the distance from the heart to the measurement site, and is calculated from the height Hi of the measured person using the coefficients a and b obtained experimentally in advance. Determined by the following equation (4):
L_e = Hi × a + b (4)

Further, the estimated value (V_e) of the pulse wave velocity is the pulse wave velocity from the heart to the brachial artery, and the blood pressure value B and age of the subject using the coefficients c, d, e that are experimentally obtained in advance. Determined from the following equation (5) from Age:
V_e = B * c + Age * d + e ... Formula (5).

  Therefore, by substituting Equation (4) and Equation (5) into Equation (3), the pulse wave propagation time T for the measurement subject can be calculated.

  Next, the reflection coefficient Γ in the artery means the ratio of the traveling wave and the reflected wave at the measurement site. The reflection coefficient depends on the degree of mismatch of the propagation characteristics at the reflection point. Specifically, the larger the difference in blood vessel diameter before and after the reflection point, the larger the reflection coefficient, and the harder the blood vessel, the larger the reflection coefficient.

  In the pulse wave detection method in which the peripheral side of the measurement site is compressed with an air bag 13A to make a blood-feeding state, and the pulse wave is detected based on a change in the internal pressure of the air bag 13B on the central side, the pulse wave is detected before and after the reflection point. The difference in blood vessel diameter changes according to the compression force of the air bag 13A. Specifically, the greater the difference between the internal pressure of the air bladder 13A and the maximum blood pressure, the more the peripheral blood vessel is crushed and the blood vessel diameter becomes smaller. As a result, the difference in blood vessel diameter increases and the reflection coefficient increases.

  It is known that the hardness of a blood vessel is estimated from a parameter obtained by analyzing a pulse wave shape detected during pressurization of the air bag 13A. As an example of the parameter, the ejection value ejected from the heart and the reflected wave from the main reflection site in the aorta are separated, and the Tr value that is the time difference between the ejection wave and the reflected wave is used. . As another example, the AI value that is the ratio of the amplitude of the ejection wave and the amplitude of the reflected wave in the blood pressure waveform, or the time difference between the appearance time of the peak of the ejection wave and the appearance time of the peak of the reflected wave (Tpp ) Etc. can also be used. In the following description, the Tr value is used as a parameter representing the hardness of the blood vessel. The smaller the Tr value, the harder the blood vessel, and as a result, the reflectance increases.

Accordingly, the intra-arterial reflection coefficient Γ is calculated from the following equation (6) by using the coefficients f, g, and h obtained experimentally in advance from the internal pressure Pa of the air bladder 13A, the highest blood pressure value SBP of the measurement subject, and the Tr value Considered to be determined in 6),
Γ = (Pa−SBP) × f + Tr × g + h (6)

  As described above, the transfer function H corresponding to the blood vessel characteristics of the subject can be calculated using the height, blood pressure value and age of the subject and the internal pressure Pa of the air bag 13A. The measuring apparatus 1 according to the present embodiment uses this transfer function H to convert the blood pressure pulse wave at the measurement site into an aortic blood pressure waveform.

  That is, the measuring apparatus 1 stores information such as height Hi and age Age as the attribute information of the measurement subject in advance. Then, using the measured blood pressure value B, the pulse wave propagation time T for the measurement subject is calculated.

  Further, in the measurement device 1, the vibration component accompanying the change in the volume of the artery superimposed on the change in the internal pressure of the air bag 13B is extracted while driving the distal side with the air bag 13A while the armband 9 is wound around the measurement site. This detects the pulse wave. As a result, the ejection wave from the heart and the reflected wave from the iliac bifurcation and the sclerosing site in the artery are separated, and the Tr value used as the parameter is calculated. Then, the reflection coefficient Γ in the artery is calculated from the internal pressure Pa of the air bag 13A, the highest blood pressure value SBP of the measurement subject, and the Tr value.

  The measuring apparatus 1 calculates the transfer function H for the measurement subject by substituting the calculated pulse wave propagation time T and the reflection coefficient Γ into the above equation (1). Then, the blood pressure pulse wave P2 (t) is converted into the aortic blood pressure waveform P1 (t) by using the transfer function H for the measured blood pressure pulse wave P2 (t) of the peripheral artery. Then, as an index of arteriosclerosis, an index (eg, AI value, Tr value) is calculated from the blood pressure waveform obtained at the measurement site, and the index is also calculated from the aortic blood pressure waveform, and these are output.

<Functional configuration>
FIG. 5 is a block diagram showing a specific example of the functional configuration of the measuring apparatus 1 for performing the above operation. Each function in FIG. 5 is mainly formed in the CPU 40 when the CPU 40 reads out and executes a program stored in the memory 5 in accordance with an operation signal from the operation unit 3. 3 may be formed with the hardware configuration shown in FIG.

  Referring to FIG. 5, the CPU 40 calculates the blood pressure value of the person to be measured based on the input unit 401 for receiving the sensor signal input from the pressure sensors 23 </ b> A and 23 </ b> B and the pressure value indicated by the sensor signal. Based on a blood pressure value calculation unit 402, a Tr calculation unit 403 for calculating a Tr value as a parameter for use in calculating the reflection coefficient Γ based on a pressure waveform indicated by the sensor signal, and a pressure value indicated by the sensor signal A pulse wave calculation unit 404 for calculating the pressure waveform at the measurement site, a reading unit 405 for reading out the height and age as the attribute information of the person to be measured from the memory 5, and the calculated blood pressure value and the read attribute Information and the propagation time calculation unit 406 for calculating the pulse wave propagation time T applied to the above equations (3) to (5), the pressure value obtained from the sensor signal, and the calculated blood pressure value were calculated. A reflection coefficient calculation unit 407 for calculating the reflection coefficient Γ by substituting the r value into the above equation (6), and the calculated pulse wave propagation time T and reflection coefficient Γ are substituted into the above equation (1). A transfer function calculation unit 408 for calculating the transfer function H, an analysis unit 409 for performing an analysis to obtain an aortic blood pressure waveform by applying the transfer function to the calculated pressure waveform at the measurement site, An index calculation unit 410 for calculating an index of arteriosclerosis from each of the blood pressure waveform and the blood pressure waveform in the aorta, and a process of outputting the calculated blood pressure value and the index of arteriosclerosis on the display unit 4 Output unit 411.

<Operation flow>
FIG. 6 is a flowchart showing the operation in the measuring apparatus 1. The operation shown in the flowchart of FIG. 6 is started when the switch 32 included in the operation unit 3 is pressed. This operation is realized by the CPU 40 reading a control program stored in the memory 5 and controlling each unit shown in FIG.

  Moreover, FIG. 7 is a figure showing the change of the internal pressure Pa of the air bag 13A and the change of the internal pressure Pb of the air bag 13B accompanying this operation.

  Referring to FIG. 6, when the measurement operation is started, CPU 40 initializes each part in step S1, and then outputs a control signal to drive circuit 26 in step S3 to operate pump 21 and compress air bag. The air bag 13A is pressurized. In the initialization of step S1, the CPU 40 outputs a control signal to the drive circuit 53 to open both valves of the 2-port valve 51. Thus, as shown in FIG. 7, as the compressed air is introduced by the pump 21 in step S3, both the internal pressure Pa of the air bladder 13A and the internal pressure Pb of the air bladder 13B increase.

  In the process of pressurization, in step S5, the CPU 40 extracts a vibration component accompanying a change in the volume of the artery superimposed on the internal pressure of the air bladder 13A, and calculates a blood pressure value by a predetermined calculation. The blood pressure value calculation method here may be a calculation method based on an oscillometric method employed in a normal electronic blood pressure monitor. At the same time, the CPU 40 determines the peripheral blood-feeding state.

  As an example of a method for determining the peripheral blood-feeding state, the CPU 40 detects a pulse wave from the vibration component accompanying the volume change of the artery superimposed on the internal pressure of the air bladder 13A, and calculates a Tr value as an index value. Then, by determining whether or not the Tr value has converged, the peripheral blood-feeding state is determined. That is, the calculated index value is compared with the index value previously calculated and temporarily stored, and the difference is less than a prestored threshold value (for example, 10% of the average value for two beats). If it is, it is determined that it has converged. Note that other indices such as an AI value may be used.

  While the peripheral side blood transfusion is not completed (NO in step S9), the CPU 40 repeats the pressurization of the air bag 13A in step S3 and the blood pressure measurement in step S5. As a result, as shown in FIG. 7, both the internal pressure Pa of the air bladder 13A and the internal pressure Pb of the air bladder 13B are increased until the peripheral blood feeding is completed.

  If it is determined that the index value has converged and it is determined that the peripheral side blood transfusion has been completed (YES in step S9), the CPU 40 outputs a control signal to the drive circuit 26 and pressurizes in step S11. Is stopped, and the internal pressure of the air bag 13A is fixed. Thereafter, in step S13, the CPU 40 outputs a control signal to the drive circuit 53 to close both valves of the 2-port valve 51. As a result, the air bag 13A and the air bag 13B are separated from each other, and the air bag 13A maintains the internal pressure at which it is determined that the peripheral side blood pumping has been completed and compresses the measurement site. A peripheral blood-feeding state is maintained with respect to the air bag 13B used. That is, the air bag 13A functions as a pressure air bag.

  In addition, when detecting a pulse wave, it is not limited to what uses an air bag as this member for compression. That is, in the measurement apparatus 1, as long as it is a member capable of compressing the distal side of the measurement site, other members such as a wire may be used instead of the air bag.

  In step S12, the CPU 40 calculates a transfer function H. This detailed operation will be described later.

  In step S15, the CPU 40 measures the output waveform from the vibration component of the internal pressure of the air bag 13B on which the pulse wave is superimposed, and detects the pulse wave. Thereafter, in step S17, the CPU 40 outputs a control signal to the drive circuit 53 to open the 2-port valve 51, and further outputs a control signal to the drive circuit 27 to open the exhaust valve 22, thereby quickly opening the air bags 13A and 13B. Exhaust. Accordingly, as shown in FIG. 7, the internal pressures Pa and Pb of the air bags 13A and 13B rapidly return to the atmospheric pressure after step S17.

  In step S19, the CPU 40 calculates the aortic blood pressure waveform by applying the transfer function calculated in step S12 to the pulse wave in the measurement site (upper arm) detected in step S15. In step S21, the CPU 40 calculates an AI value, a Tr value, or the like as an index of arteriosclerosis from the blood pressure waveform detected in step S15, and becomes an index of arteriosclerosis from the aortic blood pressure waveform obtained in step S19. An AI value, a Tr value, and the like are calculated.

  In step S23, the CPU 40 executes a process for displaying the blood pressure value measured in step S5, the index calculated in step S21, and the like on the display unit 4 as a measurement result, and ends a series of measurement operations.

  FIG. 8 is a flowchart showing the operation for calculating the transfer function in step S12. Referring to FIG. 8, first, in step S31, CPU 40 calculates a Tr value from a pulse wave obtained from a measurement site. Here, the Tr value may be calculated again from the pulse wave obtained when it is determined in step S9 that the peripheral side blood transfusion has been completed, or the Tr value used in the determination and determined to have converged. A value may be used.

  In step S33, the CPU 40 calculates a pulse wave propagation time T. Here, the CPU 40 substitutes the height Hi stored in the memory 5 as the attribute information of the person to be measured into the above formula (4), and stores the blood pressure value B measured in step S5 and the memory 5 in the memory 5. The age Age stored as attribute information is substituted into the above equation (5), and both results are substituted into the above equation (3) to calculate the pulse wave propagation time T.

  In step S35, the CPU 40 acquires the internal pressure Pa of the air bladder 13A fixed in step S11, and calculates the reflection coefficient Γ in step S37. Here, the CPU 40 uses the internal pressure Pa of the air bladder 13A acquired in step S35, the systolic blood pressure value SBP obtained by the measurement in step S5, and the Tr value calculated in step S31 in the above equation (6). By substituting, the reflection coefficient Γ is calculated.

  In step S39, the CPU 40 substitutes the pulse wave propagation time T calculated in step S33 and the reflection coefficient Γ calculated in step S37 into the above equation (1), so that the transfer function H for the subject is measured. Is calculated.

<Effect of Embodiment>
By performing the above operation, the measurement device 1 is used to wrap the arm band 9 around a measurement site such as the upper arm and perform the measurement operation, so that in addition to the blood pressure value and the pulse, the blood pressure waveform at the measurement site. In addition to the index of arteriosclerosis obtained from the above, an index of arteriosclerosis obtained from the aortic blood pressure waveform is obtained.

  FIG. 9 is a diagram illustrating a display example in the measurement apparatus 1. Referring to FIG. 9, in measurement apparatus 1, after the measurement operation, the maximum blood pressure value, the minimum blood pressure value, the pulse rate, and the calculated arteriosclerosis index as the measurement results at the upper arm that is the measurement site are used. In addition to the AI value and Tr value, the blood pressure waveform at the measurement site is converted into an aortic blood pressure waveform, and the maximum blood pressure value, AI value, and Tr value obtained from the blood pressure waveform are displayed.

  That is, by using the measuring apparatus 1, in addition to the advantage that the aortic blood pressure waveform can be obtained without imposing the burden on the subject to measure the aortic blood pressure waveform using a catheter, There is an advantage that the aortic blood pressure waveform can be obtained with high accuracy because the blood pressure waveform at the measurement site is converted into the aortic blood pressure waveform using a transfer function determined according to the blood vessel characteristics such as attribute information (age, height). Therefore, an index of the degree of arteriosclerosis based on the aortic blood pressure waveform can be calculated with higher accuracy.

  The embodiment disclosed this time should be considered as illustrative in all points and not restrictive. The scope of the present invention is defined by the terms of the claims, rather than the description above, and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims.

  DESCRIPTION OF SYMBOLS 1 Measuring apparatus, 2 base | substrate, 3 operation part, 4 display part, 5 memory, 8 air tube, 9 armband, 13A, 13B air bag, 21 pump, 22 exhaust valve, 23A, 23B pressure sensor, 26, 27, 53 Drive circuit, 28A, 28B amplifier, 29A, 29B A / D converter, 31, 32 switch, 40 CPU, 512 2-port valve, 100 upper arm, 401 input unit, 402 Blood pressure value calculation unit, 403 Tr calculation unit, 404 pulse Wave calculation unit, 405 reading unit, 406 propagation time calculation unit, 407 reflection coefficient calculation unit, 408 transfer function calculation unit, 409 analysis unit, 410 index calculation unit, 411 output unit.

Claims (4)

A blood pressure information measuring device for non-invasively detecting a blood pressure waveform in an aorta and calculating an arteriosclerosis index,
A fluid bag for mounting on the measurement site of the subject;
Compression means for compressing the peripheral side of the measurement site;
Calculating means for calculating an arteriosclerosis index of the subject based on a change in pressure of the fluid bag attached to the measurement site when the distal side of the measurement site is compressed by the compression unit and in a blood-feeding state; With
The computing means is
A process of calculating a blood pressure value of the subject based on the pressure change;
A process of calculating a pulse wave propagation time from the heart to the measurement site using the blood pressure value;
Using the difference between the compression force of the compression means in the blood-feeding state and the calculated maximum blood pressure value of the subject, and the value representing the blood vessel hardness of the subject obtained from the pressure change, Processing for calculating a reflection coefficient of blood at the measurement site;
A process of calculating a transfer function using the pulse wave propagation time and the reflection coefficient;
A process for calculating a blood pressure waveform in the aorta by applying the transfer function to a pressure pulse wave obtained from the pressure change;
A blood pressure information measuring device that executes processing for calculating an arteriosclerosis index of the subject from a blood pressure waveform in the aorta. The calculation means has a pulse wave amplitude, an AI (Augmentation Index) value that is a ratio of the amplitude of the ejection wave and the amplitude of the reflected wave, as a value representing the hardness of the blood vessel of the subject obtained from the pressure change, One of a Tr (Time of Reflection) value that is a difference in appearance time between the ejection wave and the reflected wave, and a value that represents a time difference between the appearance time of the peak of the ejection wave and the appearance time of the peak of the reflected wave using the value, the blood pressure information measurement device according to claim 1. As the subject's attribute information, further comprising storage means for storing at least age and height,
The process of calculating the pulse wave propagation time is as follows:
Processing for calculating an estimated value of the pulse wave propagation distance using the height of the subject;
Calculating the estimated value of the pulse wave velocity from the calculated blood pressure value of the subject and the age of the subject,
In processing the calculation means for calculating the pulse wave propagation time, to calculate the pulse wave propagation time an estimate of the pulse wave propagation distance is divided by the estimated value of the pulse wave velocity, according to claim 1 or 2 The blood pressure information measuring device described in 1. The calculation means further executes a process of calculating an arteriosclerosis index of the subject from a blood pressure waveform at the measurement site based on the pressure change,
An output means for outputting the calculated arteriosclerosis index;
Said output means, said arteriosclerosis index calculated from the blood pressure waveform of the aorta, and outputs the said arteriosclerotic index calculated from the blood pressure waveform at the measurement site, any one of claims 1 to 3 The blood pressure information measuring device described in 1.

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