JP5615804B2 - Medical and basic cosmetic (skin care) polymer material and method for producing the same - Google Patents

Description

  TECHNICAL FIELD The present invention relates to a medical and basic cosmetic (skin care) polymer material applied to and used for wound covering protective materials and cosmetics, and a method for producing the same. In particular, it is a technique related to the combination of an acidic polymer material based on alginic acid and a basic polymer material.

For medical products typified by wound dressings, for example, products using calcium alginate have already been approved and distributed. It is known that when alginic acid binds to calcium ions, it gels and has insoluble properties. And since this property is reversible, it is also known that calcium is separated by a chemical equilibrium action, and is again released from the gel state and dissolved.
As the acidic polymer material, a trade name “Cultost” (manufactured by Convatec) in which the calcium alginate is made into a fiber form is in circulation.

  On the other hand, basic polymer materials include chitin and chitosan. Chitosan is a polymer material having an antibacterial action and is a known material. This chitin (poly-N-acetylglucosamine) is known to have a wound healing effect by actions such as fibroblast proliferation, angiogenesis, and wound tissue repair. It also excels in exudate water absorption, analgesic effect and hemostatic effect, and promotes normal granulation and epidermis formation. Furthermore, since it is not antigenic, it does not cause inflammation. A chitin-based product utilizing these properties is approved and marketed under the trade name “Vesquitin”.

Research has been conducted on methods of using polymer materials in combination with the characteristics of each material. For example, a method is known in which an acidic polymer material typified by alginic acid and a basic polymer material typified by chitosan are used as a composite to form fibers or membranes (see Patent Document 1).
In addition, regarding a composite material, a lamination method is known in which a ready-made fiber component dispersed in a solution is collected by filtration, dehydrated, and processed into a sheet shape (see Patent Document 2).
Furthermore, as a sheet manufacturing method, an anionic polymer and a polyvalent cation compound capable of crosslinking with an anionic polymer are mixed with an aqueous medium to form a gel material having a specific viscosity, and then formed into a sheet shape in a mold. Thus, a method for obtaining a bio-attached gel sheet has been disclosed (see Patent Document 3).

  Alginic acid, an anionic polymer, becomes an insoluble gel by coexistence with multivalent ions such as calcium salts. When a wound dressing protective material using this property is produced, it has hemostatic effect, analgesic effect (pain reducing effect), and mucosal protective effect. Use is disclosed (see Patent Document 4).

In addition, the hemostatic effect of wound dressing protective materials using calcium alginate is due to the exchange of a certain amount due to the equilibrium action between calcium ions and sodium ions in living tissues. It is not appropriate to consider only cytotoxicity, and it is disclosed that calcium is limited to a predetermined range (see Patent Document 5).
In addition, this disclosure has approved and commercialized a covalently crosslinked alginate gel, which is proposed to stabilize the insoluble gel state by avoiding calcium gel ion release and dissolution of alginic acid. ing.

Regarding the cytotoxicity, it is known that endotoxin contained in alginic acid as a raw material is a problem, and reduced alginic acid is used (see Patent Document 6). In addition, as described above, a method of forming a fiber or a film by using an acidic polymer material typified by alginic acid and a basic polymer material typified by chitosan as a composite has been described, and heparin is used for this composite. It is known (see Patent Document 7).
This heparin contains a sugar called the constituent monosaccharide iduronic acid, and iduronic acid contains an amino group, so it can be said to be a cationic biopolymer. Further, it is described that the crosslinked alginic acid containing heparin has a sustained release property of a growth factor, and is therefore useful for wound treatment and tissue engineering.

It has been reported that a complex formed by mixing with chitosan using fucoidan instead of heparin can similarly release FGF (fibroblast growth factor), which is a heparin-binding factor. (Refer nonpatent literature 1).
Further, in the complexation, there is a problem that the solubility of the acidic polymer and the basic molecule varies depending on the pH. And the basic molecule chitosan only dissolves in acidic solution. Therefore, a chitosan derivative that improves the solubility in the neutral region and ensures a variety of uses has been disclosed (see Patent Document 8).

JP 2002-128958 A JP-A-8-224293 WO2002 / 032405 JP 2001-212227 A JP-A-2005-75815 JP 2007-75425 A JP 2001-233786 A WO2000 / 27889

Shingo Nakamura et al .: Journal of Biomedical Materials Research Part A, Vol.85A, (3), P.619-627, (2008) Aoki: Japanese Journal of Taste and Smell, Vol.14, No.2, pp.145-152 (2007)

  In the present invention, a so-called complex (hybridization) composed of a plurality of polymers in which an acidic polymer and a basic polymer coexist, even if the solubility characteristics of the respective polymers are different, It is intended to provide a medical and basic cosmetic (skin care) polymer material that can be combined. In particular, it can be combined at any concentration, making it easy to design the blending concentration of each polymer, and after dissolving the polymer powder in an aqueous solution etc., it does not form a sheet, but at a high concentration It is an object of the present invention to provide a medical and basic cosmetic (skin care) polymer material that can eliminate the difficulty of molding and the difficulty of degassing due to the viscosity of a polymer solution.

In view of the above problems, the present invention
1) For medical and basic cosmetics (skin care), characterized in that a mixed powder containing an acidic polymer and a basic polymer is coated on a support sheet and then impregnated with a metal ion solution and subjected to an ionic crosslinking reaction treatment. ) Manufacturing method of polymer material,
2) Medical and basic cosmetics (for skin care) as described in 1 above, wherein after the ionic crosslinking reaction treatment, the film formed on the support sheet is subjected to perforation treatment and again subjected to ionic crosslinking reaction treatment. Production method of polymer material,
3) After the ionic crosslinking reaction treatment, the polymer solubility condition is changed, and the ionic crosslinking reaction treatment is performed again. Manufacturing method of molecular material,
4) The method for producing a wound-coated sheet according to any one of 1 to 3 above, wherein after all the ionic cross-linking reactions have been equilibrated, the polymer solubility condition is set to a pH neutral region.
5) The medical and basic cosmetic (skin care) polymer material according to any one of 1 to 4 above, wherein the chemical cross-linking reaction treatment is performed after all ionic cross-linking reactions have been equilibrated. A manufacturing method is provided.
6) The method for producing a medical and basic cosmetic (skin care) polymer material according to any one of the above 1 to 5, wherein the ionic crosslinking reaction treatment and the chemical crosslinking treatment are used in combination.

In addition, the present invention
7) A medical and basic cosmetic (skin care) polymer material comprising an ionic cross-linked structure in the surface layer part of a powder sheet-like solubilized complex containing an acidic polymer and a basic polymer,
8) The medical sheet according to claim 7, further comprising an ionic cross-linked vertical structure formed by perforation treatment inside a powder sheet-solubilized complex containing an acidic polymer and a basic polymer. And basic cosmetic (skin care) polymer materials,
9) The medical and basic cosmetic (skin care) polymer material as described in 7 or 8 above, comprising an acidic polymer and a basic polymer having different solubility conditions;
10) A cross-linked complex containing an acidic polymer and a basic polymer, and having an ionic cross-linked structure and a chemical cross-linked structure, the medical use and the base according to any one of 7 to 9 above Polymeric materials for cosmetics (for skin care),
11) A wound-like gel sheet 12 comprising the medical and basic cosmetic (skin care) polymer material described in 7-10 above, and further comprising a chemical cross-linking structure in the ionic cross-linking structure. A method for producing a medical and basic cosmetic (skin care) polymer material according to any one of 7 to 11 above.

  In the present invention, since the powdered polymer material is used as a starting material, the concentration of the material to be mixed is not limited. Therefore, the medical and basic cosmetics (skin care) having the functions and characteristics of each material. It is possible to realize a polymer material. In addition, since the polymer powder is not dissolved into an aqueous solution and then formed into a sheet, the medical solution eliminates the difficulty of molding and degassing due to the viscosity of the polymer solution at high concentrations. And, it has an effect that it can realize a polymer material for basic makeup (for skin care). For this reason, for example, it has the outstanding effect that the design and manufacture of the sheet | seat material which has healing promotion effect in the intractable wound site | part which exhibited the functionality which a raw material has became possible.

It is a conceptual diagram (cross-sectional view) explaining the manufacturing process of a medical and basic cosmetic (skin care) polymer material. It is a flowchart regarding the manufacturing process of a medical and basic cosmetic (skin care) polymer material. It is the test result which determined biocompatibility with the cultured cell. It is the observation result which evaluated the wound healing effect of the medical and basic cosmetic (skin care) polymer material by the thickness of the granulation tissue of the healing part of an intractable rat model. It is the observation result which evaluated the wound healing effect of the polymer material for medical and basic cosmetics (for skin care) by the number of new blood vessels of the healing part of an intractable rat model.

For medical and basic cosmetic (skin care) polymer materials, a mixed powder containing an acidic polymer and a basic polymer is applied to a support sheet and then impregnated with a metal ion solution to be subjected to an ionic crosslinking reaction treatment. Manufactured by.
Here, the support sheet only needs to be non-ionic, and for example, filter paper made of cellulose can be used. The filter paper may have a circular shape or a square shape, or may have a shape that has been punched in accordance with the place of attachment, or a shape that has been wound up like a roll paper.

Examples of the acidic polymer include natural polysaccharides such as alginic acid, fucoidan, carrageenan, and funolan. In addition, there are synthetic polymers such as polylactic acid. As the basic polymer, for example, natural polysaccharides such as chitin and chitosan and partially processed polysaccharides can be used.
As the base material of the sheet material of the present invention, a polymer having a crosslinking action by polyvalent ions can be used. For example, alginic acid which is an acidic polymer can be used as the base material. This alginic acid is a particularly desirable substrate, but other cross-linking polymers can be used as well.
What is characteristic in the present invention is that these polymers are mixed in a dry powder and combined. The polymer provided in the form of an aqueous solution can be pulverized by freeze vacuum drying, and this powder can also be used.

Since the present invention uses powder mixing, the solubility of the polymer to be mixed is not hindered, and therefore any polymer can be selected. However, it is preferable to use a polymer material having high ion crosslinkability with polyvalent metal ions. For example, sodium alginate can be used.
When sodium alginate is mixed, the mixing ratio can be arbitrarily selected. Specifically, it can be about 100% to several percent. Here, about 100% means that other polysaccharides are slightly doped into the powder of sodium alginate.

(Powder application, temporary holding)
First, powder is applied to the support sheet. At this time, when the support sheet is sterilized, it is immersed in hydrogen peroxide water to create a wet state. Next, a certain amount of the mixed powder is uniformly applied to the surface. Specifically, the mixed powder can be sprinkled by placing a support sheet on a stainless steel pad. A powdering tool such as that used in thin layer chromatography can also be used.

After applying the powder, water or the like is sprayed again on the top surface. Thereby, a thin film of sodium alginate can be formed on the powder body surface.
At this time, it is necessary to lift up the support sheet to give moisture to the extent that the powder does not fall out. Sodium alginate has the property of high water absorption, but if too much water is added, solids that are difficult to dissolve may be formed. Therefore, it is necessary to suppress the amount of water to be sprayed to an extent that the temporary pressing of the powder can be achieved to avoid excessive spraying.

(Swelling treatment)
Next, an alcohol is impregnated into the powder body having a film formed on the surface. As the alcohol, methanol, ethanol, isopropanol and the like can be used. In addition, an alcohol concentration of 40% to 99% can be used. This concentration is a concentration at which when many of the polymers are water-soluble, they become insoluble and precipitate. When the alcohol is impregnated, the alcohol is impregnated without entraining bubbles inside the temporarily pressed powder body.

  Through the above steps, the powder body is immersed in pure water to swell. At this time, water permeates to the powder surface by the action of the impregnated alcohol. Further, although the swelling time depends on the basis weight, a sufficient state can be obtained in about several minutes. If it is performed for an excessive amount of time, the powder surface may collapse. In that case, for example, using a shallow container such as a petri dish, the support sheet can be gently moved in parallel to prevent the powder surface from collapsing. In addition, this method can be referred to a photo-hand-baked development process.

(Ionic crosslinking reaction and acid treatment)
Next, this powder body is immersed in a highly concentrated polyvalent metal ion solution. Thereby, an ionic crosslinking reaction can be caused. Specifically, when sodium alginate is used, it can be soaked in a calcium chloride solution.
In this case, the concentration of calcium chloride is about 1M to 3M, preferably about 2M. The immersion time is preferably about 1 to 30 seconds.
This is the time during which sodium alginate becomes calcium alginate and a film can be formed.

Thereafter, the powder body on which the calcium alginate film is formed is immersed in an organic acid acidic solution. This is because the inside of the calcium alginate film becomes acidic, so that other acidic polymers and basic polymers are solubilized and have a complementary ionic relationship.
Here, alginic acid, an acidic polymer, dissolves in neutral and alkaline solutions, but has an acid-insoluble precipitate property when acidic. Further, fucoidan, an acidic polymer, is solubilized with a neutral or acidic solution. Furthermore, chitin is a polymer that becomes chitosan depending on the degree of deacetylation, but is usually insoluble regardless of pH.

As described above, the complexing of the acidic polymer and the basic molecule can be handled as a solubilized solution only when the solubility conditions match. However, in general, when these are solubilized at the same time, there may be a phenomenon in which a coagulation action appears due to the interaction of the charge of the biopolymer and insolubilization occurs.
Therefore, for example, when chitosan and fucoidan coexist, chitosan and fucoidan in a complementary ionic relationship cancel each other out to form a composite and induce an insolubilization phenomenon. In addition, alginic acid that has not been cross-linked by the calcium salt is also insoluble, so it is not involved in the complexation of chitosan and fucoidan.
Here, it is preferable to use acetic acid, citric acid, malic acid, tartaric acid and the like as the organic acid. However, any acid having an equilibrium constant pKa of about 4 can be used. The immersion time is preferably 30 seconds to 3 minutes.

(Spiking)
A spiking treatment is applied to the organic acidic complex formed with the calcium alginate film to open fine perforations.
By this spiking, a longitudinal structure of a crosslinked structure can be constructed during reion crosslinking. Moreover, dissolution of the alkaline solubilizing molecule in the pH shift treatment can be promoted.

Spiking can be performed using an instrument in which sturdy sharp needles are installed at a constant density, such as Kenzan used in flower arrangement. Further, it may be a roller-like one in which a needle is fixed to a strong cylindrical support, such as a part incorporated in the music box. With this spiking instrument, the needle portion can be pressed against the surface film of the composite and pierced to the support sheet surface.
Spiking has a thickness of about 0.3 mm to 1.5 mm per 1 cm ² , and preferably about 18 to 5 pieces.

(PH shift treatment with alkaline solution)
After spiking, soak in a strong alkaline solution. Thereby, pH can be shifted from organic acid acidity to alkalinity.
Specifically, a solution of 0.3% to 3% sodium hydroxide can be used. The immersion time is preferably about 1 minute to 60 minutes.

(Reionizing crosslinking treatment and neutralization)
After the pH shift treatment, sodium hydroxide is washed with pure water and then swollen with neutral pure water or ion-exchanged water. At this time, the swelling time is preferably about 1 to 20 minutes.
Then, it is immersed again in a calcium chloride solution, and the ionic crosslinking is reprocessed.
After that, it is immersed in, for example, Dulbecco's physiological phosphate buffer to fix the pH to neutral.

(dehydration)
Next, it is immersed in an alcohol solution. The alcohol concentration is preferably 50% to 70%. The alcohol concentration used for carrying out the subsequent chemical cross-linking is comparable. In addition, since alcohol and water substitute, this can also be said to be a dehydration process.

(Chemical cross-linking treatment)
Next, chemical crosslinking treatment is performed using an epoxy-based crosslinking agent. In addition, since it is a material finally used after sterilization, it is preferable to perform a crosslinking reaction in ethanol.

  The features of the present invention will be specifically described below. The following description is intended to facilitate understanding of the present invention, and is not limited thereto. That is, all modifications, other embodiments, and other examples based on the technical idea of the present invention are included in the present invention.

From 60 parts by weight of sodium alginate (reagent), 20 parts by weight of chitin (reagent), 4 parts by weight of fucoidan (derived from Gagome, see Non-Patent Documents 1 and 2), and 2 parts by weight of chitosan (reagent) A mixed powder was prepared.
When a circular filter paper having a diameter of 70 mm (Toyo filter paper No. 2) is used as the support sheet, the amount of the mixed powder is 0.770 g with respect to the basis weight of 200 g / m ² .
The support sheet was sterilized by immersing it in a 10-fold diluted solution of hydrogen peroxide (reagent grade) and affixed to the lid of a 90 mm petri dish. 0.770 g of the composite powder mixed in advance with a mortar and blended with a high-speed mixer was weighed and stretched from the center of the support sheet to the outside, and uniformly arranged. From above, pure water in a spray spray container was sprayed to dissolve the powder on the surface and temporarily fixed by its viscosity.

Thereafter, processing was performed according to the following procedure. FIG. 1 shows an outline of the manufacturing process of a medical and basic cosmetic (skin care) polymer material, and FIG. 2 shows a flowchart of the manufacturing process.
1. The edge of the filter paper was picked with flat tweezers and stretched to a 90 mm diameter petri dish.
Immerse in an ethanol solution for a few seconds.
2. Pure water was sprinkled on another petri dish and immersed in this for about 1 minute to swell the powder.
3. It was immersed in a 2M calcium chloride solution for 20 seconds.
4). Immerse in a 5% acetic acid solution for 1 minute.

5. Spyking was performed by pressing the needle surface of Kenzan (for flower arrangement). Kenyama
Soaked in hydrogen peroxide to maintain sterilization and hygiene.
6). It was immersed in pure water in another petri dish and washed.
7). Immerse in 1% sodium hydroxide solution for 1 minute.
8). After pre-washing with pure water, it was immersed in 400 ml of ion exchange water for 3 minutes.
9. Again, a 2M calcium chloride solution was prepared in a new petri dish and soaked for 20 seconds.
10. It was immersed in Dulbecco's phosphate buffer for about 1 minute and immersed in a container containing about 1500 ml of ion-exchanged water for about 10 minutes.
As described above, the processing time of steps 1 to 10 is about 25 minutes.

11. Next, it was immersed in a 50% ethanol solution.
12. To 10 sheets of the sheet immersed in 50% ethanol, 800 ml of an ethanol solution containing a crosslinking agent was added, and a crosslinking reaction was performed at 50 ° C. for 5 hours. The crosslinking agent was 0.1M acetic acid / Na acetate buffer solution added to 400 ml ethanol, adjusted to pH = 5.8 with hydrochloric acid, 22 ml of Quetol 651 (ethylene glycol diglycidyl ether MW174.1, WAKO, 056-03841) was added, The total volume was adjusted to 800 ml.
13. At the end of crosslinking, the pH was about 6.8. Moreover, it finished to 6.7-7.5 g / sheet at the time of completion | finish of bridge | crosslinking.
14 In order to remove the crosslinking agent, it was swollen in about 1500 ml of ion exchange water. Ion exchange water was exchanged 4 times in 2 hours, and immersed in 800 ml of 70% ethanol solution overnight for sterilization.

15. Using a gel dryer used for electrophoresis, the wound surface was vacuum-dried in such a manner that a silicon sheet sterilized with alcohol was sandwiched between sterilized Teflon sheets on the support surface, and the weight was finished in the vicinity of 4 g.
16. Finally, it was packed in a vacuum pack, blanched in hot water for 20 seconds, and heat sterilized. When it swells, it pulls up once and branches again. This is a method that should be described as a “shabu-shabu” sterilization method.

(Microbiological examination)
After going through the above steps, this was examined for microorganisms. In accordance with the provisions of the Food Sanitation Law, the back and front of the gel pad material were transferred to agar plates on a standard agar plate for viable count, and cultured at 35 ° C. As a result, it was confirmed that no colonies appeared even after 2 days.

(Inspection of residual crosslinking agent)
The residual cross-linking agent was 70% ethanol of Step 14 using capillary GC (GC main body HP5890), column DB-5 (30 m × 0.25 mm, 0.25 μm, column temperature 110 ° C., inlet 200 ° C., flame ionization). Analysis was performed using a detector 210 ° C. and split analysis. As a result, it was confirmed that it was less than 1 mg / sheet.

(In case of continuous production)
Moreover, the following method can be employ | adopted when carrying out a commercial secondary production. For example, it can be achieved by using roll-wrapped filter paper as the support sheet and using a reaction tank having a size corresponding to the processing time of each step in accordance with the feed (flow) of the filter paper per unit time.
Spiking can be done continuously with a roller type or by stamping with up and down movement at regular intervals. Moreover, the length of a reaction tank can be shortened by setting a suitable roller and putting a bend appropriately. Furthermore, it is possible to perform a chemical cross-linking which takes time after cutting after reion cross-linking.

(Preliminary test for biocompatibility)
Next, a preliminary test was conducted by the following method to determine whether the medical and basic cosmetic (skin care) polymer materials produced by the method of the Examples had biocompatibility.
Using the culture vessel shown in FIG. 3 (BDFalcon culture slide 2-compartment type (left side in FIG. 3)), normal human epidermal keratinocytes (adult-derived, Sanko Junyaku Co., Ltd., CC2501) were added at 3500 Cells / cm ² . Cultured at recommended density. The specified culture medium (Brett Kit KGM-2, product number CC3107) was used as the culture medium.

Before the cultured cells become confluent (congested state), contact the test specimens manufactured in the example and the comparative specimen of the "medical supplies that have already obtained medical device approval number" with the cells in the wells of the respective culture containers. The surface to be swelled was swelled.
Thereafter, the liquid medium is removed, and soft agar (concentration 0.75%) containing the culture medium is kept warm at around 60 ° C., poured into a culture slide in which the test piece is closely attached, and allowed to cool. The test piece and the comparison piece were fixed with soft agar.
In FIG. 3, the upper left row is an agar fixed image of a test piece, and the lower left row is an agar fixed image of a comparison piece.

Two days later, the agar and the test piece were removed, and the slide glass was fixed by dipping in Dulbecco's PBS (-) containing 2.5% glutaraldehyde for 30 minutes. Thereafter, when the cells were stained with HE staining (hematoxylin-Meyer staining), a staining group indicating the presence of cultured cells was observed at the place where the test pieces were bonded together (the upper right frame in FIG. 3). Therefore, it was determined that the medical polymer material produced based on this example was compatible with the living body.
In FIG. 3, the upper right row shows a test piece staining section, and the lower right row shows a comparison piece staining section.

(Application and effect as a wound dressing)
The wound healing promoting effect of the medical polymer material produced according to the examples was examined using a rat intractable wound model using mitomycin C (CAS No. 50-07-7). Mitomycin C is an antitumor antibiotic, but has a skin degenerative action and exhibits intractable symptoms when applied to the wound surface.
A 1 mg / ml mitomycin C solution was applied to all wounds of skin having a diameter of 15 mm created on the back of the rat, and allowed to stand for 10 minutes, and then the wound was washed with sterile water. When mitomycin C is not applied, the healing period until complete epithelialization is about one week.
On the other hand, this application treatment made it possible to create an intractable wound model that required a period of 3 weeks or longer for equivalent healing.

  The test piece manufactured according to the example and the comparison piece 2 of the “medical product having already obtained the medical device approval number” were covered on the wound part (rat, male, 8 weeks old) for 1 week, and the subsequent healing process was observed. . As a result, it was observed that the test piece 1 of the present invention completely epithelialized within 2 weeks. Compared with the subject group 3 in which the covering piece was not treated, the healing was quick for about one week.

  FIG. 4 is an observation result comparing the thickness of the granulation layer of the wound treatment part after 2 weeks. In the test piece 1, a thick recovery was recognized in the granulation tissue as compared with the subject group 3, and a difference in the healing effect was significantly recognized. Even when compared with the comparative piece 2, the test piece 1 of the present invention showed a thick recovery due to the granulation tissue.

FIG. 5 is a result of measuring the number of capillaries formed in the granulation layer of the treatment part after 2 weeks. The test piece 1 had a large number of new blood vessels as compared with the comparative piece 2 and the subject group 3, and a significant difference that can be expected to improve blood flow was observed. In particular, the number of new blood vessels increased by a factor of 2 or more as compared with Comparative Sample 2. From the above observation results of the healing process of the wound part, it was confirmed that the sheet material of the present invention has a healing promoting effect on rat intractable wounds.
The above description has focused on the healing promotion effect for medical use that requires a highly biocompatible material, but it will be easily understood that it can be used as a basic cosmetic (skin care) polymer material. The present invention includes all of these.

  The present invention is a technique for compounding several types of acidic polymer and basic polymer, and thereby can provide a biocompatible material having the characteristics of each polymer material. It is useful for consumer products such as a novel wound dressing protective material with a tissue regeneration function and a cosmetic gel pad, as a polymer material for use and basic cosmetics (skin care).

Claims (5)

  After applying a mixed powder composed of 20 parts by weight of chitin, 4 parts by weight of fucoidan and 2 parts by weight of chitosan to 60 parts by weight of sodium alginate, this was immersed in a calcium chloride solution and calcium alginate was added. After forming the film as the main component, immerse it again in the calcium chloride solution from the holes made by drilling 18 to 5 holes with a thickness of 0.3 mm to 1.5 mm per square centimeter. A method for producing a medical and basic cosmetic (skin care) polymer material, characterized in that a film containing calcium alginate as a main component is formed into a sheet shape.   The ionic cross-linking reaction treatment with calcium chloride is performed again by changing the pH, which is a polymer-soluble condition, when the ionic cross-linking reaction treatment with calcium chloride is performed. A method for producing a basic cosmetic (skin care) polymer material.   3. The medical and basic cosmetic (skin care) polymer material according to claim 1, wherein an epoxy crosslinking reaction treatment is performed after the ionic crosslinking reaction with calcium chloride is completed in equilibrium. Production method. A film composed of 20 parts by weight of chitin, 4 parts by weight of fucoidan and 2 parts by weight of chitosan is formed into a sheet form with respect to 60 parts by weight of sodium alginate, and this is immersed in a calcium chloride solution to form a film mainly composed of calcium alginate. After forming, the calcium alginate is the main component by immersing again in the calcium chloride solution from the holes made by drilling 18 to 5 holes with a thickness of 0.3 mm to 1.5 mm per square centimeter A medical and basic cosmetic (skin care) polymer material comprising an ionic cross-linked structure in which a film to be formed is formed.   5. The medical and basic cosmetic (skin care) polymer material according to claim 4, further comprising an epoxy crosslinked structure in the ionic crosslinked structure.