JP5566765B2 - Vial stopper - Google Patents

Description

  The present invention relates to a stopper used for a vial, and more particularly, to a stopper for a vial that has a simple structure but can reliably insert an injection needle or the like into a seal member during use.

  A cap made of a synthetic resin is fixed to the upper surface of a protector made of an aluminum material via a fractured portion as a stopper for sealing the opening of a bottomed cylindrical vial containing medicines and various test reagents. In some cases, a seal member for sealing the opening of the upper surface of the vial is fitted to the inner surface of the protector. When freeze-drying the drug contained in the vial, the sealing member is placed in a half-plugged position that is lifted from the opening, and in this state, the vial is placed in a vacuum freeze-drying apparatus. After storing and freeze-drying, the sealing member is switched to the full plugging position to seal the opening, and then taken out from the vacuum freeze-drying device, and the skirt of the protector is wound with a clamping machine. .

  However, the vial using the above protector made of aluminum material is composed of four kinds of materials, glass, aluminum, synthetic resin, and rubber, and there is a problem that separation is not easy at the time of disposal. The vials taken out from the vacuum freeze-drying apparatus into the atmosphere are in a reduced pressure state, whereas the seal member is still securely fixed until the protector is tightened. Therefore, there is a problem that it is not easy to ensure airtightness in the vial.

  In order to solve the above problems, a conventional vial stopper has a sealing member mounted in a cap provided with a synthetic resin cylinder and an upper wall, and this vial stopper is attached to the vial. Installed in a semi-plugging position, and after freeze-drying, switching the vial stopper to the full-plugging position in the vacuum freeze-drying device ensures that the sealing member is secured to the periphery of the vial opening by the cap. A vial stopper has been proposed (see, for example, Patent Document 1).

  That is, in this prior art, the above-mentioned synthetic resin cap is provided with an upper wall provided with a needle passing window portion, and a cylindrical portion suspended from the outer peripheral edge portion of the upper wall. A sealing member for sealing between the upper wall and the upper surface of the flange formed on the peripheral edge of the opening of the vial is fitted. Moreover, the inner surface of said cylinder part is provided with the latching means which hold | maintains said cap and the sealing member fitted to this in the whole stoppering attitude | position.

  When the cap for the vial and the seal member fitted therein are switched from the half-plugging position to the full-plugging position in the vacuum freeze-drying apparatus, the locking means is used for the vial. The upper wall of the cap is held in a state of firmly pressing the sealing member against the upper surface of the collar.

JP 07-165252 A

  The vial stopper is pressed by the upper shelf plate by narrowing the shelf interval in the vacuum freeze-drying apparatus, and is switched from the half-plugging posture to the full-plugging posture. At this time, if the pressing force for switching to the full stoppering posture is excessively high, the vial may be damaged, and is set to 60 N or less, for example. However, there are variations in dimensions such as the overall height of the vial, the thickness of the flange portion of the seal member, the horizontal level of the shelf plate of the vacuum freeze-drying apparatus, and the height between the shelf plates in multiple stages. For example, the thickness tolerance of the flange portion of the seal member is set to, for example, ± 0.3 mm. In particular, when the vial is made of glass, the overall dimensional tolerance is as large as ± 0.5 mm. For this reason, for example, if a plurality of vials such as 6000 are moved by a certain size to switch the vial stoppers to the full stoppering posture, all the vials are reliably stoppered. There is a possibility that the seal member cannot be pressed or the seal member cannot be pressed firmly with the upper wall of the cap.

  On the other hand, when taking out the contents stored in the vial, the injection needle is pierced in the vicinity of the center of the upper surface of the seal member through the needle passing window formed in the center of the upper wall of the cap. A solution or the like is injected into the vial through the needle, or the dissolved contents are taken out. At this time, if the flange portion of the seal member cannot be firmly pressed against the upper surface of the vial by the upper wall of the cap, the central portion of the seal member is moved into the vial by the pressing force when the injection needle is pierced. There is a risk that the needle will not be able to pierce into the seal member by being pushed away, and this tendency is particularly great when using a thick needle such as a double-ended needle. Further, the leg portion formed on the lower surface of the seal member is inserted into the opening of the vial. However, when the injection needle is inserted into the seal member from an oblique direction, the tip of the injection needle is mistakenly May pierce the leg. At this time, if the flange portion of the seal member cannot be pressed firmly as described above, the flange portion may be drawn into the vial via the leg portion by pushing the injection needle.

  The technical problem of the present invention is to provide a vial stopper that eliminates the above-mentioned problems and has a simple structure but can reliably insert an injection needle or the like into a seal member during use.

In order to solve the above-described problems, the present invention is configured as follows, for example, based on FIGS. 1 to 14 showing an embodiment of the present invention.
That is, the present invention relates to a vial stopper, which is a vial stopper that seals the opening (6) opened at the upper end of the vial (2), and has a flange (7) around the opening (6). ) And a rubber-elastic seal member (8) attached to cover the opening (6), and the seal member (8) to the upper surface of the flange (7). And a synthetic resin cap (9) for pressing and fixing, and the sealing member (8) has a flange portion (10) mounted on the upper surface of the flange portion (7). The cap (9) includes an upper wall (15) disposed above the flange portion (10), a cylindrical portion (16) suspended from the outer peripheral edge of the upper wall (15), and the cylindrical portion (16 ) And an engaging portion (18) that can be engaged with the lower surface of the collar (7), and the opening (6) of the lower surface of the upper wall (15). Larger than the inner diameter of the seal member and the flange of the seal member (8). A small annular portion than the outer diameter of the part (10), characterized in that the receiving projection portion projecting downward (27) is formed.

  When the vial stopper is switched to the full stoppering posture, the flange portion of the seal member is pressed against the upper surface around the opening of the vial by the upper wall. At this time, since the above-described receiving projection is in a state of biting into the upper surface of the flange portion, the flange portion is prevented from shifting in the direction of diameter reduction, and the upper wall of the cap and the upper surface of the vial It is held firmly between. As a result, when the injection needle or the like is pierced into the central portion of the seal member to take out the contents contained in the vial, the seal member is prevented from being pushed into the vial by the pressing force of the injection needle or the like. Even if the tip of the injection needle is accidentally stuck into the leg portion of the seal member, the flange portion is prevented from being pulled into the vial through the leg portion, so that the injection needle or the like can be reliably inserted into the seal member. Is done.

  The receiving protrusion is not limited to a specific shape or structure as long as it is formed on the annular portion of the lower surface of the upper wall. It is preferable to form an annular shape that surrounds the flange portion over the entire periphery of the opening. In this case, the annular shape surrounding the opening may be discontinuous in the circumferential direction, but is more preferably an annular shape that is continuous in the circumferential direction.

  When a convex portion is formed on the upper surface of the flange portion of the sealing member, the convex portion is received by the convex portion when the convex portion for receiving is formed on the radially inner side of the convex portion. Since it is latched to the projection part for use, the flange part of the seal member can be reliably received by the projection part for receiving against the pressing force of the injection needle or the like, which is preferable.

  The receiving protrusion is not limited to one having a specific cross-sectional shape, but the vertical cross-sectional shape passing through the central axis of the opening is formed in a shape having a lower end of 90 degrees or less. This is preferable because it surely bites into the upper surface of the flange portion of the seal member. The angle of the lower end is preferably formed within 70 degrees, but if the shape is excessively sharp, the surface of the sealing member may be damaged or the strength of the receiving projection may be reduced. More preferably, it is set to 20 to 65 degrees. It is preferable that a small rounded chamfered portion having a radius of, for example, about 0.05 mm is formed at the lower end.

  In addition, the above-described cross-sectional shape reliably receives the flange portion that is attracted to the central portion side when the included angle formed between the radially outer surface and the vertical line extending upward from the lower end is 45 degrees or less. Preferably, the included angle is approximately 0 degrees, that is, the outer surface is formed in a vertical state.

  The height of the receiving projection is not limited to a specific value. For example, when the height is 0.3 to 2.0 mm, the flange that is attracted toward the center can be reliably received, and the seal There is no fear of damaging the surface of the member, which is preferable.

  The sealing member is not limited to a specific material. For example, a synthetic rubber material or a thermoplastic elastomer is preferably used as a main raw material because a sealing member having excellent sealing performance can be manufactured with stable quality.

  The contents contained in the vial are not limited to specific ones, and may be, for example, powder preparations, liquids, etc. A lyophilized preparation is particularly preferable because it can be easily switched to the whole plugging posture.

  Since the vial stopper according to the present invention is configured and operates as described above, the following effects can be obtained.

  Although it is a simple structure that only has a receiving projection on the lower surface of the cap, the above-mentioned receiving projection has been bitten into the upper surface of the flange portion of the seal member in the entire stoppering posture. The flange portion can be prevented from shifting in the diameter reducing direction. As a result, when inserting the injection needle or the like into the seal member at the time of use, even if the central portion of the seal member receives the pressing force of the injection needle or the like, the flange portion is not pulled toward the central portion side. It is possible to prevent the seal member from being pushed into the vial by the pressing force of the needle or the like, and even if the tip of the injection needle is accidentally stuck into the leg portion of the seal member, the flange portion is inserted into the vial through the leg portion. Since it can prevent being pulled in, an injection needle etc. can be pierced reliably to a sealing member.

FIG. 4 is a longitudinal sectional view of a vial showing the embodiment of the present invention and having a vial stopper attached in a half-plugging posture. It is sectional drawing of the stopper for vials which switched to the whole stoppering attitude | position of embodiment of this invention. It is a partially broken top view of the cap of embodiment of this invention. FIG. 4 is a cross-sectional view taken along line IV-IV in FIG. 3. It is an expanded sectional view of the important section of a cap main part of an embodiment of the present invention. It is a top view of a seal member of an embodiment of the present invention. FIG. 7 is a cross-sectional view taken along line VII-VII in FIG. 6. FIG. 8 is a cross-sectional view taken along line VIII-VIII in FIG. 6. It is an expanded sectional view of the important section of a cap showing modification 1 of an embodiment of the present invention. It is a top view of a locking member which shows modification 2 of an embodiment of the present invention. FIG. 11A is a plan view of a sealing member, and FIG. 11B is a longitudinal sectional view of the sealing member according to a third modification of the embodiment of the present invention. FIG. 12A is a plan view of a seal member and FIG. 12B is a longitudinal sectional view of the seal member according to a fourth modification of the embodiment of the present invention. FIG. 13A is a plan view of a seal member, and FIG. 13B is a vertical cross-sectional view of the seal member according to a fifth modification of the embodiment of the present invention. FIG. 14A is a plan view of a seal member, and FIG. 14B is a vertical cross-sectional view of the seal member according to a sixth modification of the embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
1 to 8 show an embodiment of the present invention, and FIG. 1 is a longitudinal sectional view of a vial (2) in which a vial stopper (1) is mounted in a half-plugging posture (Y). The vial (2) is provided with a bottomed cylindrical body (3), and a housing part (4) is formed in the body (3). Containers such as medicines are stored in the storage section (4). A neck portion (5) extends above the trunk portion (3), and an opening (6) is formed at the upper end of the neck portion (5). Around the opening (6), a flange (7) bulging outward in the radial direction is formed.

  The vial stopper (1) is mounted so as to cover the opening (6), and a synthetic rubber sealing member (8) having rubber elasticity such as butyl rubber, and the sealing member ( 8) and a synthetic resin cap (9) to be mounted on the cover.

  The sealing member (8) includes a disc-shaped flange portion (10) placed on the upper surface of the flange portion (7), and a cylindrical shape that hangs down from the center of the lower surface of the flange portion (10). And a leg (11). The leg (11) is formed with a notch (12) from the lower end to the middle in the vertical direction. The upper end of the notch (12) is located above the opening (6) in the half-plugging position (Y) shown in FIG. 1, and the inside of the housing (4) is the opening. It communicates with the external space through the space between (6) and the notch (12). The outer diameter of the leg (11) is slightly larger than the inner diameter of the opening (6), and is slightly compressed and inserted into the opening (6).

  The cap (9) includes a cap body (13) and a lid (14) fixed above the cap body (13). The cap body (13) is attached to the upper wall (15) disposed above the flange portion (10), the cylindrical portion (16) suspended from the outer peripheral edge thereof, and the inner surface of the cylindrical portion (16). And an annular locking member (17). A locking portion (18) is formed at the upper end of the locking member (17), and a needle passing window portion (19) is opened at the center of the upper wall (15). . A cylindrical sealing portion (20) hangs down from the center of the lower surface of the lid portion (14) so as to be inserted into the needle passing window portion (19).

  The vial stopper (1) is pressed from above after the contents in the vial (2) are freeze-dried and switched to the full stoppering posture (X) shown in FIG. In this all-plugging posture (X), the upper wall (15) of the cap (9) ensures that the flange portion (10) of the seal member (8) is firmly positioned on the upper surface around the opening (6) of the vial (2). And the opening (6) is sealed. At this time, since the locking portion (18) is locked to the lower surface of the flange (7) of the vial (2), the cap (9) is held in the full stoppering posture (X). The Further, the lower end of the sealing part (20) bites into the upper surface of the sealing member (8), whereby the central part of the upper surface of the sealing member (8) is shut off from the external space in an airtight manner.

  As shown in FIGS. 3 and 4, the upper surface of the cap body (13) has recesses (21) for injection molding gates formed at two locations. An annular groove (22) is formed so as to surround the window (19). On the other hand, there are four projections (23) on the lower surface of the lid (14), and the tip of the junction projection (23) is welded to the inner surface of the concave groove (22). Thus, the lid (14) is fixed to the upper surface of the cap body (13).

  As shown in FIG. 4, the locking member (17) is fitted to a fitting protrusion (24) formed on the inner peripheral surface of the cylindrical portion (16). The locking member (17) is provided with a plurality of the locking portions (18) protruding obliquely upward in the diameter reducing direction at a predetermined interval. Each locking portion (18) has a hinge (25) formed at the base, and is configured such that the upper end can be shifted in the diameter increasing direction. On the inner peripheral surface of the locking member (17), a ventilation groove (26) is formed between the locking portions (18). In the half-plugging posture (Y) shown in FIG. 1, the accommodating portion is interposed between the opening (6) and the notch (12) and the ventilation groove (26) in this order. (4) The inside communicates with the external space.

  As shown in FIG. 2 and FIG. 4, the lower surface of the upper wall (15) of the cap body (13) is larger than the inner diameter of the opening (6) and the flange of the seal member (8). A receiving projection (27) projecting downward is formed in an annular portion smaller than the outer diameter of the portion (10). The receiving projection (27) is formed in a continuous annular shape surrounding the opening (6) in plan view. As shown in FIG. 5, the vertical sectional shape of the receiving projection (27) passing through the central axis (28) of the opening (6) is 90 degrees or less, for example, 45 degrees. It is formed so that This cross-sectional shape is formed such that the radially outer surface is perpendicular to the central axis (28). The height (L) of the receiving projection (27) is set to 0.5 mm, for example.

  On the other hand, the sealing member (8) is in contact with the outer peripheral edge of the flange portion (10) in plan view on the upper surface of the flange portion (10) as shown in FIGS. A compression convex portion (29) is formed in an annular shape along the periphery. Since this compression convex part (29) is formed in the state which contact | connects the outer periphery of the flange part (10) by planar view, as shown, for example in FIG.7 and FIG.8, the surrounding side surface of a flange part (10) Is long in the vertical direction. As a result, when the cap (9) is mounted on the outside of the seal member (8) in the half-plugging posture (Y) shown in FIG. 1, the cylindrical portion (16) of the cap (9) The cap (9) is mounted in an appropriate posture guided by a long peripheral side surface in the vertical direction and the central axis of the cylindrical portion (16) being in the vertical direction.

  In the compression convex portion (29), discontinuous portions (30) are formed at four locations in the circumferential direction, and a space surrounded by the compression convex portion (29) is defined as the discontinuous portion (30). ) To communicate with outside. For this reason, when this seal member (8) is attached to the vial (2) in the half-plugging posture (Y), or during the handling, washing, sterilization, etc., the attachment means, handling device, It is possible to effectively prevent the sealing member (8) from being adsorbed to the processing apparatus or other objects as if it were a suction cup. A piercing recess (31) is provided in the center of the upper surface of the flange (10). In the above embodiment, the discontinuous portion (30) is formed at four locations in the circumferential direction of the compression convex portion (29). However, in the present invention, the discontinuous portions may be formed at three or less locations in the circumferential direction, or may be formed at five or more locations.

  As shown in FIG. 1, the receiving projection (27) is formed radially inside the compression projection (29), and the seal member (8) tries to move radially inward. Or the deformation projection (27) receives the compression projection (29). The height (h) of the compression convex portion (29) is set to, for example, 0.8 mm, and the thickness of the flange portion (10) at the portion where the compression convex portion (29) is not formed. When the thickness (t) is, for example, 3.5 mm, the dimension is set to about 23% of the thickness (t) of the flange portion (10).

  The vial (2) equipped with the above-described vial stopper (1) in the half-plugging posture (Y) shown in FIG. 1 is accommodated in a vacuum freeze-drying apparatus (not shown) and lyophilized under reduced pressure. The vial stopper (1) is switched to the full stoppering posture (X) shown in FIG. 2 by being pressed from above by the shelf. At this time, the sealing member (8) is compressed by first pressing the compression projection (29) by the upper wall (15) of the cap body (13). ) Is flattened, and the flange portion (10) of the other part is pressed and compressed. At this time, as shown in FIG. 2, the receiving protrusion (27) is in a state of being bitten into the upper surface of the flange (10). Therefore, the flange (10) has a reduced diameter. It is prevented from moving in the direction and is securely held between the upper wall (15) of the cap (9) and the upper surface of the vial (2).

  The compression convex portion (29) is only a part of the entire flange portion (10), so it is easily compressed with a low pressing force, and the lower flange portion ( 10) is pressed against the upper surface around the opening (6) of the vial (2). Since the convex portion for compression (29) is formed in an annular shape along the outer peripheral edge of the flange portion (10), the opening portion is formed by pressing the flange portion (10) against the upper surface of the vial (2). (6) is sealed against the external space. Further, even if there is a variation based on the dimensional tolerance of each member, the compression convex portion (29) is set to a height that can sufficiently reduce the variation, for example, with a low pressing force of about 30 N per piece. Even if it is stoppered, the opening (6) of the vial (2) is securely sealed.

  The compression convex portion (29) is formed in a state in contact with the outer peripheral edge of the flange portion (10) in a plan view, and is formed in the widest range on the upper surface of the flange portion (10). The pressing force by the cap (9) is well dispersed, and the flange portion (10) is pressed uniformly. Moreover, when pressed by the upper wall (15) of the cap (9), the upper surface of the seal member (8) is stably maintained in a horizontal state, and the seal member (8) is placed in an appropriate posture in the vial (2). It is plugged into the opening (6).

From the vial (2) sealed with the above-described vial stopper (1), the contents are taken out by the following procedure at the time of use.
First, the lid portion (14) of the cap (9) is removed from the cap body (13) due to the breaking of the joining projection (23), and the piercing recess (31) of the seal member (8) is It is exposed to the outside through the needle passage window (19). Next, the injection needle is pierced into the piercing recess (31), and a solution or the like is injected into the container (4) of the vial (2) to make the container liquid. The contents are removed.

  At this time, the receiving projection (27) bites into the upper surface of the flange (10) of the seal member (8), and the compression projection (29) is the receiving projection. Since it is received by (27), the flange portion (10) does not move in the direction of diameter reduction. As a result, it is possible to prevent the seal member (8) from being pushed into the vial (2) from the opening (6) when the needle is pierced into the piercing recess (31), and Even if the tip of the injection needle is accidentally pierced into the leg portion of the seal member, the flange portion is prevented from being pulled into the vial through the leg portion, so that the above-described injection needle is securely attached to the seal member (8). Can be pierced.

In the embodiment described above, the cross-sectional shape of the receiving projection (27) is such that the radially outer surface is formed in a vertical direction parallel to the central axis (28) of the opening (6). . However, the cross section of the receiving projection of the present invention is not limited to a specific shape.
For example, in the first modification shown in FIG. 9, the angle of the lower end of the cross-sectional shape in the vertical direction passing through the central axis of the opening of the receiving projection (27) is set to about 60 degrees. The included angle (α) formed between the radially outer surface and the vertical line extending upward from the lower end is set to 45 degrees or less, for example, 30 degrees.

  FIG. 10 shows a second modified example of the embodiment of the present invention. In the inner peripheral surface of the locking member (17), a ventilation groove (26) between the locking portions (18) is provided for posture stabilization. Ribs (32) are formed in the vertical direction. The diameter of the imaginary circle connecting the inner ends of the posture stabilizing ribs (32) is substantially the same as or slightly smaller than the outer diameter of the collar (7) of the vial (2). . For this reason, when the cap (9) provided with the locking member (17) is attached to the vial (2), the central axis of the cylinder (16) is the central axis of the opening (6) of the vial (2). Installed in vial (2) with proper half-plugging posture (Y) consistent with (28).

The compression projections (29) formed on the seal member (8) can be formed in various shapes as necessary, as in the modifications shown in FIGS. 11 to 14, for example.
That is, in the third modification shown in FIG. 11, the compression convex portion (29) is formed in a continuous annular shape without a break. In addition, a plurality of lower portions (33) lower than the other portions are formed at a plurality of locations of the compression convex portion (29), and the space surrounded by the compression convex portions (29) is the lower portion ( The seal member (8) is prevented from being adsorbed to other objects so that it can communicate with the outside via the upper part of 33).

  In the fourth modification shown in FIG. 12, the compression convex portion (29) is formed in a continuous annular shape without any break as in the third modification, but instead of the lower portion (33) in the third modification. Further, an adhesion preventing projection (34) for preventing adhesion to other objects is formed on the upper surface of the compression projection (29). The space surrounded by the compression convex portion (29) can communicate with the outside through the space around the adhesion prevention convex portion (34).

  In the modified example 5 shown in FIG. 13, the convex portions for compression (29) are formed in the shape of dots arranged in an annular shape in plan view, and the annular portion (35) lower than the convex portions for compression (29) The compression convex portions (29) are connected to each other.

  In the sixth modification shown in FIG. 14, a plurality of compression projections (29) are formed along the outer peripheral edge of the flange portion (10), and each compression projection (29) is radially inward in plan view. It is formed in an elongated oval shape. In the case of this modified example 6, when compressed by the upper wall of the cap, the lower flange portion (10) is pressed against the upper surface of the vial over a wide range.

  The vial stoppers described in the above embodiments and modifications are illustrated to embody the technical idea of the present invention, and the shape, dimensions, materials, and the like of each part are described in this embodiment and modifications. The present invention is not limited to those described above, and various modifications can be made within the scope of the claims of the present invention.

  For example, in the above-described embodiment or modification, the above-described compression convex portion is formed on the upper surface of the above-described seal member so as to be in contact with the outer peripheral edge of the flange portion in plan view. However, in the present invention, the convex portion is not limited to the one for compression. For example, the convex portion may be a convex portion for other uses such as a convex portion for preventing adhesion to other objects during handling, and the formation position thereof. Alternatively, it may be formed at a position spaced inward from the outer peripheral edge of the flange portion as long as it is outside the above-described receiving projection. Furthermore, according to the present invention, if the above-described receiving projections bite into the upper surface of the flange portion and the flange portion can be sufficiently prevented from moving or deforming in the direction of diameter reduction, the above-mentioned convex portions can be omitted. It is.

  In the above embodiment, the locking portion is formed on a locking member that is separate from the cylindrical portion. However, in the present invention, the locking portion may be formed integrally with the cylindrical portion. Further, the cylindrical portion may be formed with a vent hole or a slit that communicates the inside of the vial housing portion with the external space.

  In the above embodiment, the needle passing window provided on the upper wall of the cap body is covered with the lid, and the lid is removed by breaking the joint protrusion. Vials and unopened vials can be easily distinguished. However, in the present invention, it is also possible to cover the needle passing window with a sealing film that cannot be resealed, and to omit the lid.

In the above embodiment, a synthetic rubber material such as butyl rubber is used. However, in this invention, you may form with the material which uses other synthetic rubbers, thermoplastic elastomers, etc. as a main raw material.
Furthermore, in the above embodiment, the case where the contents are freeze-dried by vacuum has been described. However, the vial using the present invention may contain other items such as powder preparations and liquids without vacuum lyophilization.
Further, the inside of the vial may be in a positive pressure state other than a vacuum state or a reduced pressure state, and may be filled with an inert gas such as nitrogen gas with respect to the contents.
Needless to say, the cross-sectional shape, dimensions, and the like of the above-described receiving projections and compression projections are not limited to those of the above-described embodiment.

  The vial stopper according to the present invention is particularly suitable as a stopper for sealing a vial containing a vacuum freeze-dried preparation because it can be reliably pierced with an injection needle or the like during use while having a simple structure. However, it is also suitable for vials containing other contents.

DESCRIPTION OF SYMBOLS 1 ... Vial stopper 2 ... Vial 6 ... Opening part 7 ... Eaves part 8 ... Sealing member 9 ... Cap
10… Flange part
15… Upper wall
16 ... Cylinder part
18 ... Locking part
27 ... Reception protrusion
28 ... Center axis of opening (6)
29… Convex (compression convex)
L: Height of receiving projection (27) α: Narrow angle formed between the radially outer surface of receiving projection (27) and a vertical line extending upward from the lower end thereof

Claims (6)

A vial stopper for sealing the opening (6) opened at the upper end of the vial (2),
A collar (7) is formed around the opening (6),
A rubber-sealed seal member (8) mounted in a state of covering the opening (6), and a synthetic resin that presses and fixes the seal member (8) to the upper surface of the flange (7) A cap (9),
Said sealing member (8) has a flange part (10) mounted on the upper surface of said collar part (7),
The cap (9) includes an upper wall (15) disposed above the flange portion (10), a cylindrical portion (16) suspended from the outer peripheral edge of the upper wall (15), and the cylindrical portion. A locking portion (18) that is disposed inward of (16) and can be locked to the lower surface of the collar portion (7),
Of the lower surface of the upper wall (15), an annular portion that is larger than the inner diameter of the opening (6) and smaller than the outer diameter of the flange portion (10) of the seal member (8) In the stopper for the vial in which the receiving projection (27) protruding to the side is formed ,
An annular compression convex portion (29) having a discontinuous portion (30) is formed on the peripheral edge of the upper surface of the flange portion (10), and the receiving portion is disposed radially inward of the compression convex portion (29). A protrusion (27) is formed, an annular locking member (17) is mounted on the inner surface of the cylindrical portion (16), and posture stabilizing ribs (32) are formed in the vertical direction of the locking member (17). The diameter of the virtual circle formed and connecting the inner end of the posture stabilizing rib (32) is substantially the same as or slightly smaller than the outer diameter of the flange (7) . Plug body. The receiving projections of the above (27), a vertical cross-section passing through the central axis (28) of the openings (6) has a lower end is formed below 90 degrees, to claim 1 The vial stopper as described. The vertical cross-sectional shape of the receiving projection (27) passing through the central axis (28) of the opening (6) is a radially outer surface, and a vertical line extending upward from the lower end. The vial stopper according to claim 1 or 2 , wherein the included angle (α) is between 45 degrees or less. The vial stopper according to any one of claims 1 to 3 , wherein a height (L) of the receiving projection (27) is 0.3 to 2.0 mm. 5. The vial stopper according to claim 1 , wherein the seal member is made of at least one of a synthetic rubber material and a thermoplastic elastomer as a main raw material. The vial stopper according to any one of claims 1 to 5 , wherein the container accommodated in the vial (2) is any one of a freeze-dried preparation, a powder preparation, and a liquid preparation.

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