JP5525027B2 - Topical skin preparation - Google Patents

Description

  The present invention relates to an external preparation for skin. More specifically, it is an external preparation for skin that contains tricalcium phosphate powder carrying silver, alum, and zinc oxide, and has excellent color fastness when adhering to clothes, as well as antiperspirant and deodorant effects. The present invention relates to a skin external preparation that is extremely excellent. The skin external preparation of the present invention is preferably used as a skin deodorizing external preparation, deodorant cosmetic, antiperspirant cosmetic, deodorant cosmetic and the like for the purpose of deodorization.

  Patent Document 1 discloses the use of silver-supported calcium phosphate as a deodorant. Although there is a description that an antiperspirant can be blended in the deodorant, there is no description about an antiperspirant that can be specifically blended, and there is no discoloration when blending an antiperspirant. Not listed.

  In Patent Document 2, it is described that when an antibacterial zeolite and zinc oxide powder are combined and dispersed in water, the base is discolored and clothes are easily soiled. This discoloration is caused by a specific dicarboxylic acid. A deodorant composition to prevent is disclosed. Thus, when antibacterial zeolite is used for a skin external preparation, discoloration tends to occur when combined with zinc oxide.

  Patent Document 3 discloses a deodorant cosmetic that is superior in formulation stability and can prevent discoloration based on antibacterial zeolite when blended with a combination of antibacterial zeolite and alum or baked alum that functions as an antiperspirant.

Japanese Patent Laid-Open No. 08-126690 JP 2007-289452 A JP 2004-307375 A

  In light of the above-mentioned background art, the present inventors have conducted extensive research on the use of a specific silver-supported tricalcium phosphate as a deodorant.As a result, even when combining silver-supported tricalcium phosphate with zinc oxide, It has been found that discoloration does not occur as in the case of combining antibacterial zeolite and zinc oxide, but discoloration occurs when adhering to clothes when combined with an antiperspirant alum. And it discovered that the discoloration which generate | occur | produces when combining silver carrying tricalcium phosphate and alum can mix | blend the said discoloration when it mix | blends zinc oxide, and came to complete this invention.

  SUMMARY OF THE INVENTION An object of the present invention is to provide a skin external preparation capable of suppressing discoloration at the time of attachment to clothes by a skin external preparation in combination with silver-supported tricalcium phosphate functioning as a deodorant and an antiperspirant alum. Is to provide.

That is, the present invention is a skin external preparation characterized by containing silver-supported tricalcium phosphate, alum, and zinc oxide, and the content of alum is 1 to 20 with respect to the total amount of the skin external preparation. Further, the present invention provides a skin external preparation characterized by having a water content of less than 5% by weight based on the total amount of the skin external preparation .

Moreover, this invention provides said skin external preparation characterized by suppressing the discoloration which the said skin external preparation generate | occur | produces at the time of clothing adhesion .

  Furthermore, this invention provides said skin external preparation characterized by the said skin external preparation being aerosol spray-like deodorant cosmetics.

ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation which can suppress the discoloration at the time of the clothing adhesion by the skin external preparation which combined silver carrying tricalcium phosphate and the antiperspirant alum with zinc oxide is provided. I can do it.
Moreover, the skin external preparation of this invention has the advantage that there is little discoloration compared with the skin external preparation using a silver carrying antibacterial zeolite.

"Silver-supported tricalcium phosphate"
The silver-supported tricalcium phosphate used in the present invention is a white powder in which silver is supported on tricalcium phosphate. In the present invention, a commercially available product (Apacider C: Sangi Co., Ltd.) can be preferably used.

0.1-20 mass% is preferable with respect to the skin external preparation whole quantity, and, as for the compounding quantity of silver carrying | support tricalcium phosphate, 0.1-10 mass% is more preferable.
If the blending amount is less than 0.1% by mass, the function as a deodorant may not be sufficiently exhibited. Moreover, when it exceeds 20 mass%, when the skin external preparation of this invention is apply | coated to skin, white may become conspicuous too much.

"Alum"
Alum used in the present invention is an essential component that functions as an antiperspirant. In the present invention, commercially available powder is used. The alum used in the present invention may be a baked alum. As the commercial product, for example, TIACE S150, TIACE S100, TIACE K150, TIACE K20 (Daiming Chemical Industry Co., Ltd.) and the like are preferably used.

1-20 mass% is preferable with respect to the skin external preparation whole quantity, and, as for the compounding quantity of alum, More preferably, it is 2-10 mass%.
If the blending amount is less than 1% by mass, the function as an antiperspirant may not be sufficiently exhibited. Moreover, when it exceeds 20 mass%, when the skin external preparation of this invention is apply | coated to skin, white may become conspicuous too much.

  When alum is blended in an aerosol spray, the average particle diameter of alum is preferably 0.01 to 50 μm fine particle powder. The average particle diameter is measured by a conventional method such as a number average diameter by image analysis of a transmission electron micrograph.

"Zinc oxide"
In the external preparation for skin of the present invention, when the silver-supported tricalcium phosphate and alum are combined, the present inventors have found that discoloration occurs when the external preparation for skin adheres to clothes. It was found to be inhibited by blending.
That is, in the present invention, zinc oxide is an essential component that functions as a discoloration inhibitor when clothes are attached.
In the present invention, zinc oxide is blended as a powder. The manufacturing method and particle diameter of zinc oxide are not limited.
The deodorant composition using antibacterial zeolite tends to cause discoloration particularly when zinc oxide powder is blended in the aqueous composition, but the deodorant composition using silver-supported tricalcium phosphate is aqueous. Even when zinc oxide powder is blended in the composition, discoloration does not occur unlike antibacterial zeolite. On the contrary, zinc oxide exerts a remarkable effect that cannot be predicted by those skilled in the art of suppressing discoloration at the time of adhering clothes that occurs when silver-supported tricalcium phosphate is combined with alum.

The blending amount of zinc oxide is preferably 0.05 to 10% by mass, more preferably 0.1 to 5% by mass with respect to the total amount of the external preparation for skin.
When the blending amount is less than 0.05% by mass, the discoloration suppressing effect may not be sufficiently exhibited. On the other hand, if it exceeds 10% by mass, whiteness may be too conspicuous when applied.

  In addition to the essential components described above, the skin external preparation of the present invention is appropriately formulated with other components usually used in skin external preparations, for example, one or two or more of the components exemplified below as needed. According to the dosage form to be manufactured, it can manufacture by a conventional method. Preferable products are deodorant cosmetics and antiperspirant cosmetics which are deodorant skin external preparations.

Examples of oils include camellia oil, macadamia nut oil, corn oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, linseed oil, safflower oil, cottonseed oil, evening primrose oil, soybean oil, Liquid fats such as peanut oil, tea seed oil, kaya oil, rice bran oil, jojoba oil, germ oil, triglycerin, trioctanoic acid glycerin, triisopalmitic acid glycerin;
Solid oils and fats such as cocoa butter, coconut oil, hydrogenated coconut oil, palm oil, palm kernel oil, owl kernel oil, hydrogenated oil, owl, hydrogenated castor oil;
Waxes such as beeswax, candelilla wax, carnauba wax, lanolin;
Hydrocarbons such as liquid paraffin, ozokerite, squalene, paraffin, ceresin, squalane, petrolatum, microcrystalline wax;
Isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, hexyl laurate, myristyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, isocetyl stearate, isocetyl isostearate, 12-hydroxystearyl acid Cholesteryl, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylol triisostearate Propane, pentaerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, triisos Trimethylolpropane acrylate, cetyl-2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, glyceride tri-2-heptylundecanoate, 2-heptylundecyl palmitate, diisopropyl adipate, N-lauroyl -L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate , Ester oils such as diisopropyl sebacate and 2-ethylhexyl succinate;
Higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, lanolin fatty acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid;
Lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glycerin ether (batyl alcohol), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl Linear or branched higher alcohols such as alcohol and octyldodecanol;
Examples thereof include silicone oils such as dimethylpolysiloxane and methylphenylpolysiloxane.

Examples of the surfactant include fatty acid soap, alkyl ether sulfate ester salt, N-acyl sarcosine acid such as sodium lauroyl sarcosine, higher fatty acid amide such as sodium N-myristoyl-N-methyl taurate, sodium coconut oil fatty acid methyl tauride sodium and the like. Sulfated oils such as sulfonic acid, monolauroyl monoethanolamide POE sodium sulfosuccinate, sulfolauric acid salt such as sodium lauryl polypropylene glycol sulfosuccinate, alkylbenzene sulfonate, N-acyl glutamate, higher fatty acid ester sulfate, funnel oil , POE alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, higher fatty acid ester sulfonate, secondary alcohol sulfate ester salt, higher fatty acid alkylo Amide sulfate, anionic surfactants such as lauroyl sodium monoethanolamide succinate;
An alkyltrimethylammonium salt such as stearyltrimethylammonium chloride; a dialkyldimethylammonium salt such as distearyldimethylammonium chloride; an alkylpyridinium salt such as cetylpyridinium chloride; and a cationic surfactant such as benzalkonium chloride;
Imidazoline-based amphoteric surfactants such as 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt;
Amphoteric surfactants such as betaine surfactants such as amide betaine and sulfobetaine;
Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan trioleate;
Glycerin polyglycerin fatty acids such as mono cottonseed oil fatty acid glycerin, glyceryl monostearate, glyceryl sesquioleate, glyceryl monostearate malate;
Propylene glycol fatty acid esters such as propylene glycol monostearate;
Lipophilic nonionic surfactants such as hydrogenated castor oil derivatives, glycerin alkyl ethers, POE / methylpolysiloxane copolymers;
POE sorbitan fatty acid esters such as POE sorbitan monooleate and POE sorbitan monostearate;
POE sorbite fatty acid esters such as POE sorbite monolaurate, POE sorbite monooleate, POE sorbite monostearate;
POE glycerol fatty acid esters such as POE glycerol monooleate and POE glycerol distearate;
POE fatty acid esters of POE distearate;
POE alkyl ethers such as POE lauryl ether and POE cholestanol ester; POE alkyl phenyl ethers such as POE octyl phenyl ether and POE nonyl phenyl ether;
POE / POP alkyl ethers such as POE / polyoxypropylene (hereinafter referred to as POP) monobutyl ether, POE / POP cetyl ether, POE / POP glycerin ether;
POE hydrogenated castor oil derivatives such as POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil maleic acid;
Alkanolamides such as coconut oil fatty acid diethanolamide, fatty acid isopropanolamide;
Examples thereof include hydrophilic nonionic surfactants such as POE propylene glycol fatty acid ester, POE fatty acid amide, POE alkylamine, sucrose fatty acid ester, and alkylethoxydimethylamine oxide.

  Examples of the powder include mica, talc, kaolin, sericite, muscovite, phlogopite, synthetic mica, saucite, biotite, lithia mica, synthetic mica, calcium carbonate, magnesium carbonate, and anhydrous silicic acid ( Silica), aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, aluminum oxide, barium sulfate, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, oxide Zinc, titanium mica (titanium oxide coated mica), fish phosphorus foil, bismuth oxychloride, boron nitride, red 228, red 226, blue 404, polyethylene powder, polymethyl methacrylate powder, polyamide resin powder (nylon powder) , Cellulose powder, organopolysiloxane elastomer, aluminum Uda, mention may be made of a copper powder and the like.

Examples of alcohols include lower alcohols such as ethanol, propanol, and isopropanol;
Cholesterol, sitosterol, lanosterol and the like can be mentioned.

Examples of thickeners include plant polymers such as gum arabic, tragacanth cam, galactan, carop gum, guar gum, carrageenan, pectin, agar, starch (corn, wheat, potato, rice);
Microbial polymers such as dextran and pullulan;
Starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch;
Cellulose polymers such as collagen, methylcellulose, ethylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, crystalline cellulose;
Alginate polymers such as sodium alginate, propylene glycol alginate;
Vinyl polymers such as polyvinyl methyl ether and carboxyvinyl polymer;
POE polymer;
POE polyoxypropylene copolymer polymer;
Acrylic polymers such as sodium polyacrylate and polyacrylate amide;
Inorganic water-soluble polymers such as bentonite, aluminum magnesium silicate, laponite, hectorite, and silicic anhydride can be used.

  Examples of chelating agents include hinokitiol, gallic acid, tannic acid, caffeic acid, ethylenediaminetetraacetic acid, ethyleneglycoldiaminetetraacetic acid, diethylenetriaminepentaacetic acid, phytic acid, polyphosphoric acid, metaphosphoric acid, analogs thereof, and alkalis thereof. Examples thereof include metal salts and carboxylic acid esters.

  Examples of the ultraviolet absorber include ultraviolet absorbers such as octyl paramethoxycinnamate, 4-tert-butyl-4′-methoxydibenzoylmethane, and octocrylene.

  Examples of the humectant include polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, xylitol, maltitol, maltose, D-mannitol, fructose, sodium hyaluronate, glucosamine, cyclo A dextrin etc. can be mentioned.

Examples of the medicinal component include vitamins such as retinol, retinol palmitate, pyridoxine hydrochloride, nicotinamide, nicotinic acid dl-α-tocopherol, magnesium ascorbate phosphate, vitamin D2, dl-α-tocopherol, pantothenic acid, biotin and the like. Kind;
Anti-inflammatory agents such as azulene and glycyrrhizin;
Whitening agents such as tranexamic acid and potassium 4-methoxysalicylate;
Astringents such as tannic acid;
Examples of the refreshing agent include L-menthol and camphor.

  Examples of the preservative include paraoxybenzoic acid esters (such as methylparaben, ethylparaben, and butylparaben), sorbic acid, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, and phenoxyethanol.

Other neutralizable agents such as 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, potassium hydroxide, triethanolamine, sodium carbonate;
PH adjusters such as lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, sodium hydrogen carbonate ammonium bicarbonate;
Antioxidants such as ascorbic acid, α-tocopherol and carotenoids can be mentioned.

The product form of the external preparation for skin of the present invention is not particularly limited. Examples include aerosol spray type, roll-on type, powder type, pressed powder (molded powder) type, and stick type.
In the present invention, an aerosol spray type is particularly preferable. In the case of an aerosol spray type, it is manufactured by filling an aerosol can with the external preparation for skin of the present invention together with a propellant such as liquefied gas and ethanol by a conventional method. In addition, although alum is inferior in dispersibility in ethanol, the new knowledge that the dispersibility of alum in ethanol improves by adding silver carrying | support tricalcium phosphate was obtained by this invention.

  Next, the present invention will be described more specifically with reference to examples. The present invention is not limited thereby. A compounding quantity is the mass% with respect to the whole quantity unless there is particular notice.

"Examples 1 to 9, Comparative Example 1"
[Deodorant spray]
After preparing a powder lotion-type deodorant lotion with the compositions of Examples and Comparative Examples shown in Table 1, it was filled in a 50 mL glass tube, and the redispersibility and sedimentation speed of the powder were evaluated by the following methods. The deodorant lotion was filled in an aerosol container with a stock solution (powder lotion): LPG gas = about 2: 8, and the discoloration when adhered to clothes was evaluated by the following method.

<Powder redispersibility>
After filling into a 50 mL glass tube and allowing to stand for 1 hour to settle the powder, the glass tube was shaken and stirred to confirm redispersibility.
<Judgment>
○: Re-dispersed with shaking within 5 times.
X: It does not re-disperse even if it shakes 20 times or more.

<Powder settling speed>
After filling into a 50 mL glass tube, the mixture was stirred uniformly and allowed to stand, and then the sedimentation rate of the powder was visually observed.
<Judgment>
○: No separation of the upper layer is observed for 20 seconds or more.
X: Separation of the upper layer is confirmed within 10 seconds.

<How to check discoloration>
The deodorant spray was applied under the armpit for 3 seconds, and a daily garment was worn for 8 hours, and then the color change was observed visually when the garment was left under room light for 2 hours.
<Judgment>
○: No discoloration is observed.
X: Discoloration is recognized.

＊１：アパサイダーＣ：株式会社サンギ
＊２：微細酸化亜鉛：堺化学工業株式会社
＊３：亜鉛華ＡＺＯ−ＢＳ：藤本化学製品株式会社
＊４：日本薬局方酸化亜鉛(水物用)：堺化学工業株式会社

* 1: Apacider C: Sangi Co., Ltd. * 2: Fine zinc oxide: Sakai Chemical Industry Co., Ltd. * 3: Zinc Hua AZO-BS: Fujimoto Chemicals Co., Ltd. * 4: Japanese Pharmacopoeia Zinc Oxide (for water): Sakai Chemical Industry Co., Ltd.

From the results of the above-mentioned “Table 1”, it can be seen that when silver-supported tricalcium phosphate and myoban are combined, discoloration occurs when attached to clothes (Comparative Example 1 and Comparative Example 2). However, it can be seen from Examples 1 to 10 and Reference Example 11 that the discoloration can be prevented by adding zinc oxide.
Further, in ethanol, alum has a problem of poor redispersibility (Comparative Example 2), but it can be understood that redispersibility is improved by adding silver-supported tricalcium phosphate, and this problem can be solved.
Furthermore, it turns out that the sedimentation speed | velocity | rate of powder will become quick when 5 mass% or more of water is mix | blended ( reference example 11). Considering the step of filling the aerosol container during production, a powder lotion having excellent redispersibility and a slow sedimentation rate is preferable. Therefore, in this invention, it is more preferable not to contain 5 mass% or more of water with respect to the powder lotion whole quantity which is a skin external preparation.

Formulation Example 1 Deodorant Spray (mass%)
(Stock solution)
Alum 5
Apacider C 10
Zinc oxide (zinc flower) 2
Silica anhydride 10
Calcium stearate 0.5
Talc 10
Corn starch 12.5
Decamethylcyclopentasiloxane 15
Methylphenylpolysiloxane 12
Cetyl 2-ethylhexanoate 8
PPG-20 decyltetradeces-10 3
Dimethicone (6cs) 12
The above components are mixed to form a deodorant stock solution, filled into a spray can, and then LPG is sealed so that the stock solution: LPG is 5:95.

Formulation Example 2 Deodorant Spray (mass%)
(Stock solution)
Alum 5
Apacider C 2
Zinc oxide (zinc flower) 1
Silicic anhydride 1
Ethanol 71.5
Cetyl 2-ethylhexanoate 10
Dimethicone (6cs) 8
PEG-9 dimethicone 1
L-Menthol 0.5
The above components are mixed to form a deodorant stock solution, filled into a spray can, and then LPG is sealed so that the stock solution: LPG is 10:90.

Formulation Example 3 Deodorant Lotion (mass%)
Alum 2
Apacider C 2
Zinc oxide (zinc flower) 1
Silicic anhydride 1
Ethanol 86.5
Glycerin 3
1,3-butylene glycol 3
L-Menthol 1
Fragrance 0.5
The above components are mixed and filled into a bottle container or a mist container to obtain a lotion-like composition.

Formulation Example 4 Deodorant Stick (mass%)
Alum 5
Apacider C 5
Zinc oxide (zinc flower) 1
Silicic anhydride 8
Solid paraffin wax 7
Stearyl alcohol 10
Liquid paraffin 10
Decamethylcyclopentasiloxane 43.5
Methylphenylpolysiloxane 8
PEG-9 dimethicone 2
Glutathione 0.5
The above components are heated and mixed, filled into a stick-like container, and cooled to room temperature to obtain a stick-like composition.

Formulation Example 5 Deodorant Powder (mass%)
Alum 3
Apacider C 2
Zinc oxide (zinc flower) 0.5
Talc 90
Silica anhydride 4.5
The said component is mixed with a mixer and a powdery composition is obtained.

ADVANTAGE OF THE INVENTION According to this invention, the skin external use which can suppress the discoloration at the time of clothes adhesion by the skin external preparation combined with the silver carrying tricalcium phosphate which functions as a deodorizer, and the antiperspirant alum by zinc oxide. Agent can be provided.
The skin external preparation of the present invention is excellent in antiperspirant effect and deodorant effect, and is extremely useful as an antiperspirant cosmetic and a deodorant cosmetic.

Claims (3)

A skin external preparation characterized by containing silver-supported tricalcium phosphate, alum, and zinc oxide, wherein the content of alum is 1 to 20% by mass relative to the total amount of the skin external preparation, The water content is less than 5% by mass based on the total amount of the external preparation for skin.
Skin external preparation. The skin external preparation according to claim 1, wherein the skin external preparation suppresses discoloration that occurs when the clothes adhere to the skin.   The skin external preparation according to claim 1 or 2, wherein the skin external preparation is an aerosol spray-like deodorant cosmetic.