JP5391323B1 - Biologic injection device - Google Patents

Abstract

[PROBLEMS] To provide a biopharmaceutical injection device that uses less power and can be reduced in size and weight.
The biopharmaceutical injecting apparatus of the present invention is a rotary motion output means for outputting a rotational motion, an injector 6 for injecting a biologic V, and an injector operating means for operating the injector 6 based on the rotational motion. And rotational motion transmitting means for transmitting the rotational motion output from the rotational motion output means to the injector operating means. The rotary motion output means is constituted by the air motor 1.
[Selection] Figure 1

Description

  The present invention relates to a biopharmaceutical injection device used when a biologic is locally injected into an affected tissue, for example, in the treatment of a disease.

  In recent years, the causes and pathologies of diseases such as cancer have been elucidated at the gene level, and research and development of cancer treatment at the gene level have been promoted.

  Under such circumstances, gene therapy for treating diseases such as cancer by introducing genes into affected tissues in the body has attracted attention and has been tried in reality.

  As a biopharmaceutical such as a gene therapy agent used for gene therapy, a product in which a gene is incorporated in a “carrier” called a vector is usually used. In gene therapy, in order to exert an effect, it is necessary to efficiently introduce a biologic into a target cell or tissue.

  2. Description of the Related Art Conventionally, a biopharmaceutical injection device for injecting a biologic into an affected area automatically extrudes the biologic contained in a syringe and injects it into the affected area, as shown in Patent Document 1, for example. Such a biopharmaceutical injection device uses, for example, an electric motor as a driving source thereof, and the biologic in the syringe is pushed out based on the driving force of the electric motor.

  On the other hand, the injection time and the injection amount of a biologic by gene therapy vary greatly depending on the use conditions, and the injection time and the injection amount range over a wide range. As an example, when the injection rate (injection amount / injection time) is the fastest, an injection operation of injecting 0.05 mL of biologic in 0.1 second is required.

  In addition, from recent experiments and research results, the injection rate at the time of start-up from the start of biopharmaceutical injection to the steady injection rate is made steep so that the steady injection rate is reached quickly, and immediately after the completion of quantitative injection. It has been found that an injection method in which the injection speed at the time of falling to the stop state is steep and quickly returned to the stop state is very effective.

Japanese Patent No. 4365003

  Under such circumstances, in order to ensure the high controllability as described above in the conventional biopharmaceutical injection device, specifically speaking, the rise time at the start of injection and the rise at the end of injection are described. In order to shorten the fall time, it is necessary to use an electric motor having a high output, for example, an electric servo motor or an electric pulse motor, as the electric motor used for the drive source of the pusher.

  However, since electric servo motors and electric pulse motors are heavy and large in size, there has been a problem that the injection apparatus itself becomes heavy and large, and the amount of power used increases.

  This invention is made | formed in view of said subject, and it aims at providing the biopharmaceutical injection apparatus which can aim at size reduction and weight reduction with little electric power consumption.

  In order to achieve the above object, the present invention has the following structure.

[1] Rotational motion output means for outputting rotational motion, an injector for injecting biologics, injector operating means for operating the injector based on rotational motion, and rotation output from the rotational motion output means A biopharmaceutical injection device comprising rotational movement transmitting means for transmitting motion to the injector operating means,
The biopharmaceutical injection device, wherein the rotary motion output means is constituted by an air motor.

  [2] The biopharmaceutical injection device according to item 1 above, wherein the rotational motion transmitting means is provided with a clutch that transmits and shuts off rotational motion.

  [3] The biopharmaceutical injection device according to the above item 2, wherein a brake for stopping the rotational motion is provided on the output side of the clutch in the rotational motion transmitting means.

[4] The injector operating means is constituted by a ball screw mechanism,
4. The biopharmaceutical injection device according to any one of the preceding items 1 to 3, wherein a rotational motion is converted into a linear motion by the ball screw mechanism, and the injector is operated based on the linear motion.

  According to the biopharmaceutical injection device of the invention [1], since a small and light air motor is used as the rotational motion output means serving as a drive source, the entire device can be reduced in size and weight, and the electric power used can be reduced. The amount can also be suppressed.

  According to the biologic injection device of the invention [2], since the clutch is provided on the output side of the air motor, when the biomotor injection is started, the clutch is connected after the rotation state of the air motor is stabilized. Thus, the driving force of the air motor can be transmitted to the injector. For this reason, the stable driving force of the air motor can be instantaneously transmitted to the injector, the rise time at the start of injection can be shortened, and the effect of injecting the biologic can be further enhanced.

  According to the biologic injection device of the invention [3], since the brake is provided on the output side of the clutch, when stopping the injection of the biologic, the clutch is disengaged and the brake is operated at the same time, whereby the air motor Inertial force during the deceleration of this does not act, and the injection operation of the injector can be stopped instantaneously. For this reason, the fall time at the end of the injection can be shortened, and the effect of the biopharmaceutical injection can be further enhanced.

  According to the biopharmaceutical injection device of the invention [4], since the ball screw mechanism is used as the injector operating means, the rotational motion can be accurately converted into a linear motion, and high feed accuracy can be secured, thereby further increasing accuracy. The biologic can be injected in a well-stabilized state.

FIG. 1 is a block diagram schematically showing a biopharmaceutical injection device according to an embodiment of the present invention.

  FIG. 1 is a block diagram schematically showing a biopharmaceutical injection device according to an embodiment of the present invention.

  As shown in the figure, this biopharmaceutical injection device includes an air motor 1, a clutch 2, a brake 3, a speed reducer 4, a ball screw mechanism 5, an injector 6, and adjacent devices 1 to 6. 1 includes a coupling 71 as a shaft coupling that connects the rotary shafts 11, 75, and 76 as basic components.

  The air motor 1 is also called an air motor or the like, and is a prime mover that uses air pressure as a power source. The air motor 1 rotationally drives the rotary drive shaft 11 by using a force generated when air compressed by a compressor expands. In the present embodiment, the air motor 1 constitutes a rotary motion output means for outputting a rotary motion to the rotary drive shaft 11.

  The air motor 1 is smaller and lighter and uses less electric power than a high output electric motor such as an electric servo motor or an electric pulse motor.

  The clutch 2 constitutes rotational motion transmission / cutoff means for transmitting the rotational motion (rotational force) on the input side to the output side, or blocking the rotational motion on the input side so that it is not transmitted to the output side. In this embodiment, the friction clutch is used. The clutch 2 includes a pair of discs 21 and 22 that are coaxially opposed to each other and can be separated from each other, and an input-side rotary shaft 75 and an output-side rotary shaft 76 are connected to each of the discs 21 and 22. Yes.

  The input side rotation shaft 75 of the clutch 2 is connected to the rotation drive shaft 11 of the air motor 1 via a coupling 71. Thereby, the rotational motion (rotational force) of the rotary drive shaft 11 of the air motor 1 is transmitted to the input side rotary shaft 75 and the input side disc 21 of the clutch 2.

  When the pair of discs 21 and 22 of the clutch 2 approach each other, that is, when the clutch 2 is connected, the rotational movement (rotational force) of the input side disc 21 is caused by the frictional force and the output side disc 22 and It is transmitted to the output side rotating shaft 76. When the pair of discs 21 and 22 are separated from each other, that is, when the clutch 2 is disengaged, the rotational motion of the input side disc 21 is not transmitted to the output side disc 22 and the transmission of the rotational motion is interrupted. It has become so.

  In the present embodiment, a friction clutch is used as the clutch 2. However, in the present invention, the type of the clutch is not particularly limited. For example, other clutches such as an electromagnetic clutch, a meshing clutch, and a conical clutch are used. A clutch may be employed.

  The brake 3 constitutes a rotational motion stopping means (braking device) for stopping the rotational motion, and is constituted by a disc brake in this embodiment. The brake 3 includes a brake rotor 31 that is rotatably arranged, and brake pads 32 and 32 that can sandwich the brake rotor 31. An input-side rotary shaft 75 and an output-side rotary shaft 76 are connected to the brake rotor 31. ing.

  The input side rotating shaft 75 of the brake 3 is connected to the output side rotating shaft 76 of the clutch 2 via a coupling 71. Thereby, the rotational motion of the output side rotating shaft 76 of the clutch 2 is transmitted to the input side rotating shaft 75 of the brake 3 so that the brake rotor 31 and the output side rotating shaft 76 rotate.

  When the brake rotor 31 is rotating and the brake rotor 31 is sandwiched between the brake pads 32 and 32, that is, when the brake 3 is operated, the brake rotor 31 is braked and stops rotating. Yes.

  In the present embodiment, a disc brake is used as the brake 3. However, in the present invention, the type of the brake is not particularly limited, and other brakes such as a drum brake are employed. May be.

  The speed reducer 4 reduces the rotational speed of the rotational motion input to the input side rotary shaft 75 and outputs it to the output side rotary shaft 76. The torque of the output side rotary shaft 76 is proportional to the reduction ratio. It has come to increase.

  The input side rotary shaft 75 of the speed reducer 4 is connected to the output side rotary shaft 76 of the brake 3 via a coupling 71. As a result, the rotational motion transmitted to the input side rotational shaft 75 of the speed reducer 4 via the output side rotational shaft 76 of the brake 3 is converted into an appropriate torque and an appropriate rotational speed by the speed reducer 4, and the output side rotational shaft. 76 is transmitted.

  In the present invention, the type of the speed reducer is not particularly limited, and for example, a gear mechanism type gear using a gear can be suitably used.

  The ball screw mechanism 5 is rotation / linear conversion means for converting rotational motion into linear motion, and constitutes an injector operation means in the present embodiment. The ball screw mechanism 5 is inserted between a support frame 51, a screw shaft 52 rotatably supported by the support frame 51, a nut 53 screwed to the screw shaft 52, and the screw shaft 52 and the nut 53. A large number of balls (not shown) for friction suppression are provided as basic components, and an input side rotating shaft 75 is connected to the screw shaft 52.

  The input side rotary shaft 75 of the ball screw mechanism 5 is connected to the output side rotary shaft 76 of the speed reducer 4 via a coupling 71. Thereby, the rotational motion of the output side rotating shaft 76 of the speed reducer 4 is transmitted to the input side rotating shaft 75 of the ball screw mechanism 5 so that the screw shaft 52 rotates.

  When the screw shaft 52 rotates in this way, the nut 53 moves along the screw shaft 52. Thereby, the rotational motion of the screw shaft 52 is converted into the linear motion of the nut 53.

  In this embodiment, the ball screw mechanism 5 is used as the injector operating means. However, in the present invention, the injector operating means is not particularly limited, and may be configured so that the injector 6 can be operated. Anything can be used. For example, rotation / linear conversion means other than the ball screw mechanism can be employed as the injector operation means.

  Further, in the present embodiment, the clutch 2, the brake 3 and the speed reducer 4, the rotary shafts 75 and 76, and the coupling 71 connecting the rotary shafts 75 and 76 function as the rotational motion transmitting means. To do.

  The injector 6 includes a cylindrical syringe 61 that accommodates the biologic V, an injection needle 62 that is attached to the distal end of the syringe 61 and that dispenses the biologic V inside the syringe 61, and a proximal end within the syringe 61. A pusher 63 that is pushed in from the side and pushes out the biologic V inside the syringe 61 is provided as a basic component.

  A pusher 63 of the injector 6 is connected to a nut 53 of the ball screw mechanism 5. Accordingly, when the nut 53 moves forward to the right in FIG. 1, the pusher 63 is pushed into the syringe 61, and the biological product V in the syringe 61 is pushed out from the injection needle 62. Yes.

  Although illustration is omitted, in the biopharmaceutical injection device of the present embodiment, a control device for controlling the driving of the entire device is provided. This control device controls the driving of each drive unit of the biologic injection device, for example, the air motor 1, the clutch 2, the brake 3, and the like, and responds to an operator (operator) command in response to the biopharmaceutical injection operation described later. Is automatically done.

  The control device is configured by, for example, a personal computer including an input unit such as a keyboard and a mouse and a display unit such as a liquid crystal display.

  Needless to say, the control device obtains necessary information, for example, the injection speed of the biologic V, the injection amount, the injection time, the remaining amount, the temperature, the injection pressure, the rotation status of the air motor, etc., based on information from various sensors. This information can be displayed via the display unit. Furthermore, when injecting the biopharmaceutical V based on such information, an injection operation with higher safety is performed.

  Moreover, as the biopharmaceutical V injected by the biopharmaceutical injection device of the present embodiment, a drug originating from an organism, particularly a gene therapy agent such as a vector incorporating a gene can be exemplified as a suitable one.

  The procedure for injecting the biologic V into the affected tissue of the patient using the biopharmaceutical injection device of the present embodiment configured as described above will be described below.

  In the initial state, the clutch 2 is in a disengaged state, that is, a state where the pair of discs 21 and 22 are separated and transmission of rotational motion (rotational force) is interrupted.

  In this state, first, the syringe 61 and the injection needle 62 in the injector 6 are filled with a predetermined amount of the biologic V. Needless to say, the injector 6 filled with the biologic V may be prepared in advance.

  Subsequently, the injection needle 62 of the injector 6 is punctured into the affected tissue.

  Next, rotational driving of the air motor 1 is started. At this time, since the clutch 2 is disconnected, the driving force of the air motor 1 is not transmitted to the devices 3 to 6 after the clutch 2.

  The rotation of the air motor 1 may be started in advance before the puncture operation of the injection needle 62.

  Next, when it is confirmed that the rotation state of the air motor 1 is stabilized, the clutch 2 is connected, that is, the pair of discs 21 and 22 are brought into contact with each other to transmit the rotation motion, and the rotation motion is transmitted from the clutch 2 onward. To each of the devices 3-5. Thereby, the input side rotating shaft 75 and the output side rotating shaft 76 of each device 3-5 after the clutch 2 rotate, the screw shaft 52 of the ball screw mechanism 5 rotates, and the nut 53 advances. As the nut 53 advances, the pusher 63 of the injector 6 is pushed into the syringe 61, and the biologic V in the syringe 61 and the injection needle 62 is poured out from the injection needle 62 and injected into the affected tissue. Is done.

  Thus, the biologic V is injected into the affected tissue, and when the injection of a predetermined amount is completed, the brake 3 is operated and the clutch 2 is disconnected. Thereby, rotation of each rotating shaft 75 and 76 and the screw shaft 52 of the ball screw mechanism 5 stops, and injection | pouring of the biologic V by the injector 6 is complete | finished.

  Further, the driving of the air motor 1 is stopped. Note that the drive of the air motor 1 may be stopped after the extraction operation of the injection needle 62 described later is completed.

  Thereafter, the injection needle 62 of the injector 6 is extracted from the affected tissue. This ends gene therapy.

  As described above, according to the biologic injection device of the present embodiment, the air motor 1 is used as a drive source. Since the air motor 1 is smaller and lighter than a high-power electric motor such as an electric servo motor or an electric pulse motor, the entire biopharmaceutical injection device can be reduced in size and weight. Further, the amount of power used can be reduced by using the air motor 1.

  Furthermore, in Japan and other countries where power conditions are different, air motors are more versatile than electric motors. Therefore, the device using the air motor 1 as a driving source like the biopharmaceutical injection device of this embodiment is easy to use overseas and can be widely spread all over the world.

  Further, according to the biologic injection device of the present embodiment, the clutch 2 is provided on the output side of the air motor 1, and when starting the injection of the biologic V, the air motor 1 is driven with the clutch 2 disconnected. Then, after the rotation state of the air motor 1 is stabilized, the clutch 2 is connected to transmit the driving force of the air motor 1 to the injector 6. For this reason, when the clutch 2 is connected, the stable driving force of the air motor 1 can be transmitted to the injector 6 instantly, and the rise time from immediately after the start of injection until the injection amount becomes stable can be shortened quickly. It is possible to reach a state with a constant injection speed (a state of quantitative injection). In other words, the rise time at the start of injection does not include the time from the start of driving of the air motor 1 until the stable state is reached, so that the state of steady injection can be instantaneously reached immediately after the start of injection. Thus, since the rise time at the start of injection can be shortened, the effect of injecting the biologic V can be further enhanced.

  Furthermore, according to the biopharmaceutical injection device of the present embodiment, the brake 3 for stopping the rotational movement is provided on the output side of the clutch 2, and the clutch 2 is disconnected when the injection of the biologic V is stopped. At the same time, the brake 3 is operated. Thereby, when the injection is stopped, the inertial force due to the deceleration of the air motor 2 does not act, so that the rotational operation of the clutch 2 and the speed reducer 4 and the forward movement of the pusher 63 of the injector 6 can be stopped instantaneously. The fall time from the state of quantitative injection until the injection is actually stopped can be shortened, and the transition from the constant amount injection state to the injection stop state can be made quickly. In other words, when the injection is stopped, the air motor 1 having a large inertia force is disconnected, and the rotary motion of the clutch 2, the speed reducer 4 and the ball screw mechanism 5 having a small inertia force is stopped by the brake 3. It is possible to instantaneously shift from the state to the injection stop state. Thus, since the fall time at the end of the injection can be shortened, the effect of the injection of the biologic V can be further enhanced.

  Moreover, in the biopharmaceutical injection device of the present embodiment, since the ball screw mechanism 5 is used as the injector operating means, the rotational motion can be efficiently and smoothly converted into a linear motion, and a high feeding accuracy can be secured. The biologic V can be injected in a more accurate and stable state.

  The biologic injection device of the present invention can be used for treating hepatitis, emphysema, arteriosclerosis, hemophilia, diabetes, Alzheimer's disease, etc. in addition to diseases such as cancer.

  In addition, as described in the above embodiment, a gene therapy agent such as a gene-incorporated vector can be suitably used as the biologic to be injected into the affected tissue, and the gene-encapsulated liposome or gene-introduced cell A gene therapy agent such as can also be suitably used.

  Furthermore, the biopharmaceutical injection device of the present invention can be suitably used as a gene therapy agent injection device for injecting the above gene into the affected tissue.

  The biopharmaceutical injection device of this invention can be used when injecting a biologic into the affected tissue.

1: Air motor (rotary motion output means)
2: Clutch 3: Brake 5: Ball screw mechanism (injector operating means)
6: Syringe V: Biologic

Claims (2)

Rotational motion output means for outputting a rotational motion; an injector for injecting a biologic; an injector operating means for operating the injector based on the rotational motion; and the rotational motion output from the rotational motion output means. A biopharmaceutical infusion device comprising rotational movement transmitting means for transmitting to the injector operating means,
The rotary motion output means is constituted by an air motor ,
The rotational motion transmitting means is provided with a clutch for transmitting and interrupting rotational motion,
A biopharmaceutical injection device characterized in that a brake for stopping the rotational motion is provided on the output side of the clutch in the rotational motion transmitting means . The injector operating means is constituted by a ball screw mechanism,
The biopharmaceutical injection device according to claim 1 , wherein the ball screw mechanism converts a rotational motion into a linear motion, and the injector is operated based on the linear motion.

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