JP5262102B2 - Optical measuring device - Google Patents

Description

The present invention relates to an optical measurement apparatus that non-invasively measures the inside of a living body using light, and in particular, by measuring a temporal change in blood flow in each part of the brain and a temporal change in oxygen supply, the living tissue is normal. The present invention relates to an optical measurement device that can be used as an oxygen monitor for diagnosing whether or not there is a cardiovascular system failure diagnosis device or the like.

Hemoglobin plays a role in carrying oxygen in the blood. Since the hemoglobin concentration contained in the blood increases or decreases according to the expansion / contraction of the blood vessel, it is known to detect the expansion / contraction of the blood vessel by measuring the hemoglobin concentration.
In view of this, there has been known a living body measuring method that uses light to measure the inside of a living body simply and non-invasively by utilizing the fact that the hemoglobin concentration corresponds to the oxygen metabolism function inside the living body. The hemoglobin concentration is determined from the amount of light obtained through the living body by irradiating the living body with light having a wavelength from visible light to the near infrared region.

Furthermore, hemoglobin binds to oxygen to become oxyhemoglobin, while away from oxygen to deoxyhemoglobin. It is also known that in the brain, oxygen is supplied to a site activated by blood flow redistribution, and the concentration of oxyhemoglobin combined with oxygen increases. Therefore, it can be applied to the observation of brain activity by measuring the oxyhemoglobin concentration. Since oxyhemoglobin and deoxyhemoglobin have different spectral absorption spectral characteristics from visible light to the near infrared region, oxyhemoglobin concentration and near-infrared light using two different wavelengths (for example, 780 nm and 850 nm) are used. Each deoxyhemoglobin concentration can be determined.

Therefore, in order to easily and non-invasively measure brain activity, an optical measuring device including a light transmitting probe and a light receiving probe has been developed. In the optical measurement device, near infrared light is irradiated to the brain by a light transmission probe arranged on the scalp surface of the subject, and near infrared light emitted from the brain is emitted by a light receiving probe arranged on the scalp surface. Detect the amount of light. By using the light transmitting probe and the light receiving probe in this manner, the oxyhemoglobin concentration and deoxyhemoglobin concentration at the measurement site of the brain, and the total hemoglobin concentration calculated from these are obtained.

Here, the relationship between the probe interval (channel) between the light transmitting probe and the light receiving probe and the measurement site of the brain will be described. FIG. 6A is a cross-sectional view showing the relationship between a pair of light-transmitting probes and light-receiving probes and the measurement site of the brain, and FIG. 6B is a plan view of FIG.
The light transmitting probe 12 is pressed against the light transmitting point T on the scalp surface of the subject, and the light receiving probe 13 is pressed against the light receiving point R on the scalp surface of the subject. And while irradiating light from the light transmission probe 12, the light reception probe 13 is made to detect the light discharge | released from the scalp surface. At this time, among the light irradiated from the light transmission point T on the scalp surface, the light passing through the banana shape (measurement region) reaches the light receiving point R on the scalp surface. As a result, in the measurement region, the light transmitting point T and the light receiving point R are particularly determined from the midpoint M of the line L connecting the light transmitting point T and the light receiving point R at the shortest distance along the scalp surface of the subject. Received light amount information (oxyhemoglobin concentration, deoxyhemoglobin concentration, and further calculated from these, depth L / 2 which is half the distance of the line connected at the shortest distance along the scalp surface of the subject. Total hemoglobin concentration).

In addition, by measuring the hemoglobin concentration, etc., at multiple measurement sites in the brain related to brain functions such as movement, sensation, and thinking, an optical measurement device applied in the medical field such as brain function diagnosis and cardiovascular system diagnosis Has been developed.
In such an optical measurement device, for example, a light transmission / reception unit having a plurality of light transmission probes and a plurality of light reception probes is used (see, for example, Patent Document 1).
In the light transmission / reception unit, a holder is used to bring a plurality of light transmission probes and a plurality of light reception probes into close contact with the scalp surface of the subject in a predetermined arrangement. As such a holder, for example, a molded holder that is molded into a scissors shape in accordance with the shape of the scalp surface is used. The molding holder is provided with a plurality of through-holes, and the light transmitting probe and the light-receiving probe are inserted into the through-holes, so that the channel is constant and light is received from a plurality of sites at specific depths from the scalp surface. Quantity information is obtained.

FIG. 2 is a plan view showing the positional relationship between 13 light transmitting probes and 12 light receiving probes in the light transmitting / receiving unit as described above. The light transmitting probe and the light receiving probe are arranged in a square lattice pattern so as to alternate in the row direction and the column direction. The transmitter / receiver unit 11 is designed in consideration of the distance from the scalp to the brain. Therefore, if the subject is an adult, the distance (channel) between the transmitter / receiver probe 12 and the receiver probe 13 is set to 30 mm. Things are used. When the channel is 30 mm, it is considered that the received light amount information at a depth of 15 mm to 20 mm from the midpoint of the channel can be obtained as described above. In other words, the position at a depth of 15 mm to 20 mm from the scalp surface substantially corresponds to the surface area of the brain, and the received light amount information related to the brain activity can be obtained.
The light emitted from the light transmitting probes 12a to 12m is also detected by the light receiving probes 13a to 13l apart from the adjacent light receiving probes 13a to 13l. However, in order to simplify the description, the adjacent light receiving probes are used here. It is assumed that only 13a to 13l are detected. Therefore, light reception amount information from a total of 40 brain surface parts is obtained.
Then, by measuring brain activity from temporal changes in received light amount information from a total of 40 brain surface regions, image processing such as averaging processing and mapping is performed on the obtained brain activity data (also called activation data). It is also performed to image by executing.
JP 2001-337033 A

However, even if the distance (channel) connecting the light transmission point T and the light receiving point R along the scalp surface of the subject with the shortest distance is 30 mm, the brain of the subject is actually used. There is a problem that not only received light amount information due to cerebral blood flow in the front part but also received light amount information due to skin blood flow in the scalp part of the subject near the light transmitting point T or near the light receiving point R is included.
Therefore, the present invention provides an optical measurement device capable of obtaining received light amount information by a measurement site such as cerebral blood flow from which unnecessary received light amount information by a shallow portion such as skin blood flow shallower than the measurement site of a subject is removed. The purpose is to do.

An optical measuring device of the present invention made to solve the above problems includes a plurality of light-transmitting probes that irradiate light on the skin surface of a subject, and a plurality of lights that receive light emitted from the skin surface of the subject. A first light transmission / reception unit having a light reception probe; and a control unit that controls light transmission / reception with respect to the first light transmission / reception unit, wherein the first light transmission / reception unit includes the light transmission probe and the light reception probe; Is an optical measuring device formed in a lattice shape alternately arranged at a first set interval, and includes a second transmitter / receiver unit arranged at a position different from the first transmitter / receiver unit, and the second transmitter / receiver unit. The light receiving unit includes a light transmission probe that irradiates light on the skin surface of the subject, and a light reception probe that receives light emitted from the skin surface of the subject, and the light transmission probe and the light reception probe The second setting interval that is the distance between the first setting interval and the second setting interval The second transmission / reception unit with respect to the skin surface of the subject is in the vicinity of the first transmission / reception unit with respect to the subject's skin surface, and the control unit The first light transmission / reception unit obtains first light reception amount information of light from the light transmission probe to the light reception probe adjacent to the light transmission probe, and the second light transmission / reception unit receives the light transmission probe. The second received light amount information of light from the light receiving probe to the light receiving probe, and using the second received light amount information, the received light amount information by the shallow part shallower than the measurement site of the subject is removed from the first received light amount information. Thus, the received light amount information of the measurement site is acquired.

Here, “the vicinity of the arrangement position of the first transmitter / receiver with respect to the skin surface of the subject” is obtained light amount information that is substantially the same as the shallow portion of the subject where the first transmitter / receiver is arranged. The position refers to, for example, the other part of the same scalp surface when the first transmitter / receiver is disposed on a part of the scalp surface of the subject. Since it is known that the received light amount information by the skin blood flow of the subject is substantially the same in a wide range of the subject, the second transmitter / receiver is connected to the skin surface of the subject in the vicinity of the first transmitter / receiver. If it arrange | positions, the received light quantity information by the skin blood flow in the site | part of the subject which has arrange | positioned the 1st light transmission / reception part is obtained.
According to the optical measurement device of the present invention, the first light transmission / reception unit is formed in a lattice shape in which light transmission probes and light reception probes are alternately arranged at a first set interval (first channel). And a 1st light transmission / reception part is arrange | positioned on the skin surface of a subject.
The second light transmitting / receiving unit is formed such that a second set interval (second channel) which is a distance between the light transmitting probe and the light receiving probe is shorter than the first set interval (first channel). Yes. That is, the second light transmitting / receiving unit does not measure the amount of light received by the measurement site (for example, cerebral blood flow) of the subject, but receives light by skin blood flow etc. in a shallow part shallower than the measurement site of the subject. Quantity information will be measured. And a 2nd light transmission / reception part is arrange | positioned on the skin surface of the subject of the vicinity of a 1st light transmission / reception part.
Thereby, the control unit acquires the first received light amount information of the light from the light transmitting probe to the light receiving probe adjacent to the light transmitting probe in the first light transmitting / receiving unit, and at the second light transmitting / receiving unit, the light transmitting probe. The second received light amount information of light from the light to the light receiving probe is acquired.
Then, the controller uses the second received light amount information to remove the received light amount information from the shallow portion (for example, skin blood flow) that is shallower than the measured region of the subject from the first received light amount information. Received light amount information (for example, cerebral blood flow) is acquired. At this time, for example, a signal (information component) between the measurement site and the shallow portion is separated using a mathematical signal separation method such as independent component analysis, and only the information component of the measurement site is extracted.

As described above, according to the optical measurement device of the present invention, it is possible to obtain light reception amount information from a measurement site (for example, cerebral blood flow) from which unnecessary light reception amount information from the shallow portion of the subject is removed. Accordingly, it is possible to accurately observe changes with time in blood flow in each part of the brain and the like and changes with time in oxygen supply.

(Means and effects for solving other problems)
Further, in the optical measuring device of the present invention, the second light transmitting / receiving unit is formed in a lattice shape in which the light transmitting probe and the light receiving probe are alternately arranged at a second set interval, and the control unit includes: The second light transmission / reception unit may acquire second light reception amount information of light from the light transmission probe to a light reception probe adjacent to the light transmission probe.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. In addition, this invention is not limited to the following embodiment, It cannot be overemphasized that various aspects are included in the range which does not deviate from the meaning of this invention.

FIG. 1 is a block diagram illustrating a configuration of an optical measurement device according to an embodiment of the present invention. FIG. 2 is a plan view showing the configuration of the first light transmitting / receiving unit, and FIG. 3 is a plan view showing the configuration of the second transmitting / receiving unit. Furthermore, FIG. 4 is a plan view showing a state when the first transmitter / receiver unit and the second transmitter / receiver unit are arranged on the scalp surface of the subject.
The optical measurement device 1 includes a first light transmission / reception unit 11, a second light transmission / reception unit 15, a light emission unit 2, a light detection unit 3, and a control unit (computer) 20 that controls the entire optical measurement device 1. Consists of.

As shown in FIG. 2, the first light transmitting / receiving unit 11 includes 13 light transmitting probes 12 a to 12 m and 12 light receiving probes 13 a to 13 l. The light transmitting probes 12 a to 12 m and the light receiving probes 13 a to 13 l. Are arranged in a square lattice so as to alternate in the row direction and the column direction. Note that the distance (first set distance) between the light transmitting probe 12 and the light receiving probe 13 is 30 mm. The twelve light transmitting probes 12a to 12m emit light, and the twelve light receiving probes 13a to 13l detect the amount of light. And the 1st light transmission / reception part 11 is mounted | worn with the subject's P scalp surface. Therefore, the 1st light transmission / reception part 11 will obtain the 1st light reception amount information regarding the brain surface site | part (measurement site | part) in the position of depth 15mm-20mm from the scalp surface. The first received light amount information is information including received light amount information due to skin blood flow in the scalp region (shallow part) of the subject P in the vicinity of the light transmitting point or in the vicinity of the light receiving point.

As shown in FIG. 3, the second light transmitting / receiving unit 15 includes five light transmitting probes 16a to 16e and four light receiving probes 17a to 17d, and the light transmitting probes 16a to 16e and the light receiving probes 17a to 17d. Are arranged in a square lattice so as to alternate in the row direction and the column direction. The distance (second set distance) between the light transmitting probe 16 and the light receiving probe 17 is 15 mm. The five light transmitting probes 16a to 16e emit light, and the four light receiving probes 17a to 17d detect the amount of light.
And as shown in FIG. 4, the 2nd light transmission / reception part 15 will be mounted | worn by the vicinity of the scalp surface of the subject P by which the 1st light transmission / reception part 11 is arrange | positioned. Therefore, the 2nd light transmission part 15 will obtain the 2nd received light quantity information regarding the scalp site | part (shallow part).
As shown in FIG. 4, the first transmitter / receiver unit 11 and the second transmitter / receiver unit 15 are arranged at different positions (a little apart) in the head, but the skin blood flow on the head surface is the entire head. Therefore, even in the positional relationship between the first transmitter / receiver unit 11 and the second transmitter / receiver unit 15 as shown in FIG. A skin blood flow signal equivalent to the skin blood flow of the subject P placed (information on the amount of light received by the skin blood flow) is obtained.

The light emitting unit 2 transmits light to one light transmitting probe selected from among the 13 light transmitting probes 12a to 12m in the first light transmitting / receiving unit 11 by a drive signal input from the computer 20. At the same time, light is transmitted to one light transmitting probe selected from among the five light transmitting probes 16a to 16e in the second light transmitting / receiving unit 15. As the light, for example, near infrared light having two different wavelengths (for example, 780 nm and 850 nm) is used.
In addition, if the light transmitting probes 12 and 16 that are far away so that light hardly interferes with each other can be transmitted simultaneously to a plurality of light transmitting probes, the efficiency of measurement can be improved. It is assumed that the light is transmitted one by one.
The light detection unit 3 individually detects near-infrared light received by the 12 light receiving probes 13a to 13l in the first light transmitting / receiving unit 11, thereby obtaining twelve received light signals (first received light amount information) by a computer. In parallel with the output to 20, four near-infrared lights received by the four light-receiving probes 17 a to 17 d in the second light transmitting / receiving unit 15 are individually detected, whereby four light-receiving signals (second light-receiving amount) are detected. Information) is output to the computer 20.

The computer 20 includes a CPU 21, and further includes a memory 25, a display device 23 having a monitor screen 23 a and the like, and a keyboard 22 a and a mouse 22 b which are input devices 22.
Further, the functions processed by the CPU 21 will be described as a block. The light transmission / reception unit control unit 4 that controls the light emitting unit 2 and the light detection unit 3, the first received light amount information acquisition unit 31, and the second received light amount information acquisition unit. 32 and a brain activity received light amount information calculation unit 33.
The memory 25 includes a first received light amount information storage unit 51 that stores a received light signal (first received light amount information) and a second received light amount information storage unit 52 that stores a received light signal (second received light amount information). Have.

The light transmission / reception unit control unit 4 receives a light emission control unit 42 that outputs a drive signal to the light emitting unit 2 and a light reception signal (first light reception amount information and second light reception amount information) from the light detection unit 3. Is stored in the memory 25.
The light emission control unit 42 performs control to output a drive signal for transmitting light to the light transmitting probe 16 to the light emitting unit 2 in parallel with transmitting light to the light transmitting probe 12.
For example, first, the light transmission probe 12a transmits light of 780 nm for 0.15 seconds, and then the light transmission probe 12b transmits light of 780 nm for 0.15 seconds. A drive signal for transmitting light of 780 nm in order to the probe 12 m is output to the light emitting unit 2. Further, after light of 780 nm is transmitted in order from the light transmission probe 12a to the light transmission probe 12m, a drive signal for transmitting light of 850 nm in order from the light transmission probe 12a to the light transmission probe 12m is similarly generated. Output to the light emitting unit 2.
Further, at the same time when light is transmitted from the light transmission probe 12a to the light transmission probe 12m, first, light of 780 nm is transmitted to the light transmission probe 16a for 0.15 seconds, and then light of 780 nm is transmitted to the light transmission probe 16b. So as to transmit light of 780 nm in order from the light-transmitting probe 16a to the light-transmitting probe 16e. Further, after light of 780 nm is transmitted in order from the light transmission probe 16a to the light transmission probe 16e, a drive signal for transmitting light of 850 nm in order from the light transmission probe 16a to the light transmission probe 16e is similarly generated. Output to the light emitting unit 2.

The light detection control unit 43 receives the light reception signal (first light reception amount information) from the light detection unit 3 and stores the light reception signal (first light reception amount information) in the first light reception amount information storage unit 51 and receives the light. By receiving the signal (second received light amount information), the received light signal (second received light amount information) is controlled to be stored in the second received light amount information storage unit 52.
For example, a light reception signal (first received light amount information) obtained by detecting the light of 780 nm transmitted from the light transmission probe 12a by the light reception probes 13a to 13l is received, and then the light of 780 nm transmitted from the light transmission probe 12b is received. 780 nm light transmitted from 13 light transmission probes 12a-12m was detected by light reception probes 13a-13l so that light reception signals (first received light amount information) detected by light reception probes 13a-13l were received. A light reception signal (first light reception amount information) is received. Further, similarly, a light reception signal (first received light amount information) obtained by detecting the light of 850 nm transmitted from the 13 light transmission probes 12a to 12m by the light reception probes 13a to 13l is received.
At the same time that the light reception signals (first received light amount information) detected by the light reception probes 13a to 13l are received, the light reception signals (second light detection signals detected by the light reception probes 17a to 17d) are received (second light reception signals 17a to 17d). 5 light reception signals (second light reception amount information) are received so that light of 780 nm transmitted from the light transmission probe 16b is detected by the light reception probes 17a to 17d. A light reception signal (second received light amount information) obtained by detecting the light of 780 nm transmitted from the light transmission probes 16a to 16e by the light reception probes 17a to 17d is received. Further, similarly, a light reception signal (second received light amount information) obtained by detecting the light of 850 nm transmitted from the five light transmission probes 16a to 16e by the light reception probes 17a to 17d is received.

The first received light amount information acquiring unit 31 is a control for acquiring first received light amount information of light received by the light receiving probe 13 adjacent to the light transmitting probe 12 from the light transmitting probe 12 in the first light transmitting / receiving unit 11. Is to do.
Specifically, the light reception signal received from the light transmission probe 12 by the light reception probe 13 adjacent to the light transmission probe 12 from the light reception signals stored in the first light reception amount information storage unit 51 is set to the depth. Acquired as the first received light amount information of 30/2 mm (brain surface part).
The second received light amount information acquiring unit 32 is a control for acquiring second received light amount information of light received by the light receiving probe 17 adjacent to the light transmitting probe 16 from the light transmitting probe 16 in the second light transmitting / receiving unit 11. Is to do.
Specifically, the light reception signal received by the light reception probe 17 adjacent to the light transmission probe 16 from the light transmission probe 16 out of the light reception signals stored in the second light reception amount information storage unit 52 Acquired as second received light amount information of (scalp site).

The brain activity received light amount information calculation unit 33 uses the second received light amount information to calculate received light amount information from the shallow part (scalp part) shallower than the measurement part (brain surface part) of the subject P from the first received light amount information. By removing the received light amount information of the measurement site, the obtained brain activity data (also referred to as activation data) is controlled by executing image processing such as averaging processing, mapping and imaging. is there.
For example, the signal (information component) between the measurement site (brain surface region) and the shallow part (scalp region) is separated using a mathematical signal separation method such as independent component analysis, and the signal of the measurement site (brain surface region) Only (information component) is extracted. Then, the obtained brain activity data is imaged by executing image processing such as averaging processing and mapping.

Next, an inspection method (biological measurement method) for measuring the brain activity at the measurement site of the brain using the optical measurement device 1 will be described. FIG. 5 is a flowchart for explaining an example of the inspection method by the optical measurement device 1.
First, in the process of step S101, the first transmitter / receiver 11 is disposed on the scalp surface of the subject P.
Next, in the process of step S102, the second transmitter / receiver unit 15 is disposed in the vicinity of the scalp surface of the subject P where the first transmitter / receiver unit 11 is disposed. That is, the second light transmitter / receiver 15 is disposed at a position where the received light amount information that is substantially the same as the shallow portion of the subject P where the first light transmitter / receiver 11 is disposed (see FIG. 4).

Next, in the process of step S <b> 103, the light emission control unit 42 outputs to the light emitting unit 2 a drive signal for transmitting light to the light transmitting probe 16 in parallel with transmitting light to the light transmitting probe 12. To do.
Next, in the process of step S104, the light detection control unit 43 receives the light reception signal (first light reception amount information) from the light detection unit 3 to thereby convert the light reception signal (first light reception amount information) into the first light reception amount information. The data is stored in the storage unit 51.
On the other hand, in the process of step S105, the light detection control unit 43 receives the light reception signal (second light reception amount information) from the light detection unit 3 to store the light reception signal (second light reception amount information) in the second light reception amount information. Store in the unit 52.

When the processes of step S104 and step S105 are completed, in the process of step S106, the first received light amount information acquisition unit 31 receives the light received adjacent to the light transmission probe 12 from the light transmission probe 12 in the first light transmission / reception unit 11. The first received light amount information of the light received by the probe 13 is acquired.
Next, in the process of step S107, the second received light amount information acquisition unit 32 receives the first light received by the light receiving probe 17 adjacent to the light transmitting probe 16 from the light transmitting probe 16 in the second light transmitting / receiving unit 11. Two light reception amount information is acquired.
Next, in the process of step S108, the brain activity light reception amount information calculation unit 33 uses the second light reception amount information to receive light by a shallow part (scalp part) shallower than the measurement part (brain surface part) of the subject P. By removing the amount information from the first received light amount information, the received light amount information of the measurement site is acquired, and the obtained brain activity data is imaged by executing image processing such as averaging processing and mapping.

As described above, according to the optical measurement device 1 of the present invention, it is possible to obtain received light amount information that hardly includes the influence of the skin blood flow or the like of the subject P. Therefore, it is possible to accurately inspect changes with time in blood flow in each part of the brain and changes in oxygen supply with time.

(Other embodiments)
(1) In the optical measuring device 1 described above, the first light transmission / reception unit 11 including the 13 light transmission probes 12a to 12m and the 12 light reception probes 13a to 13l is shown, but a different number, for example, 9 It is good also as a 1st light transmission / reception part which has a light transmission probe and nine light reception probes. Moreover, although the 2nd light transmission / reception part 15 which has five light transmission probes 16a-16e and four light reception probes 17a-17d was shown, it differs, for example, one light transmission probe and one light reception probe. (2) In the optical measuring device 1 described above, the configuration including the first light transmitting / receiving unit 11 and the second light transmitting / receiving unit 15 has been shown. It is good also as a structure provided with the 3rd light transmission / reception part formed so that the 3rd setting space | interval which is a distance between probes may become shorter than a 2nd setting space | interval.

INDUSTRIAL APPLICABILITY The present invention can be used for an optical measurement device that measures the inside of a living body non-invasively using light.

It is a block diagram which shows the structure of the optical measuring device which is one Embodiment of this invention. It is a top view which shows the structure of a 1st light transmission / reception part. It is a top view which shows the structure of a 2nd light transmission / reception part. It is a top view which shows a state when a 1st light transmission / reception part and a 2nd light transmission / reception part are arrange | positioned on the scalp surface of a subject. It is a flowchart for demonstrating an example of the inspection method by an optical measuring device. It is a figure which shows the relationship between a pair of light transmission probe and light reception probe, and the measurement site | part of a brain.

Explanation of symbols

1: Optical measuring device 11: First light transmission / reception unit 12, 16: Light transmission probe 13, 17: Light reception probe 15: Second light transmission / reception unit 20: Control unit P: Subject T: Light transmission point R: Light reception point M: Midpoint S: Measurement site

Claims (2)

A first light transmitter / receiver having a plurality of light transmitting probes for irradiating light on the skin surface of the subject and a plurality of light receiving probes for receiving light emitted from the skin surface of the subject;
A controller for controlling light transmission / reception with respect to the first light transmission / reception unit;
The first light transmission / reception unit is an optical measurement device formed in a lattice shape in which the light transmission probe and the light reception probe are alternately arranged at a first set interval,
A second transmitter / receiver disposed at a different position from the first transmitter / receiver;
The second light transmitting / receiving unit has a light transmitting probe for irradiating light on the skin surface of the subject, a light receiving probe for receiving light emitted from the skin surface of the subject, and
The second setting interval, which is the distance between the light transmitting probe and the light receiving probe, is formed to be shorter than the first setting interval,
The arrangement position of the second transmitter / receiver unit with respect to the skin surface of the subject is near the arrangement position of the first transmitter / receiver unit with respect to the skin surface of the subject,
In the first light transmitting / receiving unit, the control unit acquires first light reception amount information of light from the light transmitting probe to the light receiving probe adjacent to the light transmitting probe,
In the second light transmission / reception unit, obtain second light reception amount information of light from the light transmission probe to the light reception probe,
Using the second received light amount information, the received light amount information of the measurement site is obtained by removing the received light amount information from the shallow portion shallower than the measurement site of the subject from the first received light amount information. An optical measuring device. The second light transmission / reception unit is formed in a lattice shape in which the light transmission probe and the light reception probe are alternately arranged at a second set interval,
The said control part acquires the 2nd light reception amount information of the light from the said light transmission probe to the light reception probe adjacent to the said light transmission probe in said 2nd light transmission / reception part, The said light transmission / reception part is characterized by the above-mentioned. Optical measuring device.

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