JP5086319B2 - A microbubble-containing composition and a microbubble generator. - Google Patents
A microbubble-containing composition and a microbubble generator. Download PDFInfo
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- JP5086319B2 JP5086319B2 JP2009243940A JP2009243940A JP5086319B2 JP 5086319 B2 JP5086319 B2 JP 5086319B2 JP 2009243940 A JP2009243940 A JP 2009243940A JP 2009243940 A JP2009243940 A JP 2009243940A JP 5086319 B2 JP5086319 B2 JP 5086319B2
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- 239000000203 mixture Substances 0.000 title description 9
- 239000007789 gas Substances 0.000 claims description 87
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 37
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 14
- 239000001569 carbon dioxide Substances 0.000 claims description 14
- 230000008016 vaporization Effects 0.000 claims description 13
- 238000009834 vaporization Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 7
- 239000001301 oxygen Substances 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims 1
- 235000011089 carbon dioxide Nutrition 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 108010048295 2-isopropylmalate synthase Proteins 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000012832 cell culture technique Methods 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000012001 immunoprecipitation mass spectrometry Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- -1 that is Chemical compound 0.000 description 1
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- Devices For Medical Bathing And Washing (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Description
本発明は、主として生体表面（皮膚）に刺激を与え、表面組織を活性化させる組成物の製造装置に関するものである。
The present invention relates to an apparatus for producing a composition that mainly stimulates a biological surface (skin) and activates a surface tissue .
組成物は、いわゆる「微小気泡（マイクロバブル）」であって、バブルをなすガスが、大気、またたとえば窒素（Ｎ2）または酸素（Ｏ2）または二酸化炭素（ＣＯ2）であって、特に大気とＮ2ーＯ2ーＣＯ2組成を異にすると、通常の気泡とは異なった性質があり、生体表面（皮膚）にあたえる影響もおおきいことがわかっている。 The composition is a so-called “microbubble”, in which the gas forming the bubble is the atmosphere, for example nitrogen (N2) or oxygen (O2) or carbon dioxide (CO2), in particular the atmosphere and N2 It has been found that if the composition of O2 and CO2 is different, it has properties different from those of normal bubbles and has a great influence on the surface of the living body (skin).
この「マイクロバブル」には、低濃度タイプ：直径が30μm 付近に分布のピークがあり、気泡濃度としては数百個/mL 程度。見た目は水が少し曇った状態のもの。および、高濃度タイプ：10μm付近に気泡分布のピークがあり、気泡個数は数千個/mL 以上。見た目は牛乳のような状態のものがある。 This “microbubble” is a low-concentration type: there is a distribution peak around 30 μm in diameter, and the bubble concentration is about several hundreds / mL. It looks like a little cloudy water. And high concentration type: There is a peak of bubble distribution around 10μm, and the number of bubbles is more than several thousand / mL. It looks like milk.
本発明装置により製造される組成物には、この「マイクロバブル」が含有され、かかる気泡が生体表面（皮膚）に刺激を与え、表面組織を活性化させることで、人体に適用すれば健康増進効果がえられる。
The composition produced by the device of the present invention contains these “microbubbles”, and these air bubbles stimulate the surface of the living body (skin) and activate the surface tissue, thereby promoting health when applied to the human body. The effect is obtained.
ここで、この「マイクロバブル」２種：低濃度タイプ（30μm）、高濃度タイプ（10μm）による経験的差異は、概して、高濃度タイプ（10μm）の与える種々の効果の方が、低濃度タイプ（30μm）のそれよりもはるかに大きいということである。 Here, the empirical difference between the two types of “microbubbles”: low concentration type (30 μm) and high concentration type (10 μm) is generally different from the various effects given by the high concentration type (10 μm). It is much larger than that of (30μm).
ゆえに本発明の実施の際も同様に、高濃度タイプ（10μm）にて実施するのがよりよい効果を与える。 Therefore, when the present invention is carried out, the high concentration type (10 μm) is similarly effective.
高濃度タイプ（10μm）マイクロバブルを生成する技術は、たとえば、特許文献１に記載されている。 A technique for generating high-concentration type (10 μm) microbubbles is described in Patent Document 1, for example.
それに対し、低濃度タイプ（30μm）あるいは、さらにバブル径が大きな低級（ミリスケール）タイプによる細胞培養技術が特許文献２および特許文献３に記載されている。
On the other hand, Patent Literature 2 and
また、特許文献４および特許文献５には、本発明と同じコンセプトである「固化ガス（ドライアイス）」の気化（昇華）で得られるガスによる微小泡発生について開示している。しかし、マイクロバブルのカテゴリーにはいる前記の微小粒径の泡が効果的に生成されているかどうか疑問である。
ひるがえって、特許文献１の気体吸入についての記述は、大気圧で気体吸引をなす、渦流ポンプが用いられている。 On the contrary, the description of the gas suction in Patent Document 1 uses a vortex pump that performs gas suction at atmospheric pressure.
これら公知技術が、本発明のバックグラウンドである。
本発明の課題は、より手軽に微小泡を利用することである。具体的には、細胞培養の研究フィールドで微小泡を利用するにあたって従来、酸素ボンベ、窒素ボンベ、二酸化炭素ボンベを必要として場所をとる、という問題を解消する。 An object of the present invention is to use microbubbles more easily. Specifically, the problem of using an oxygen cylinder, a nitrogen cylinder, and a carbon dioxide cylinder in order to use microbubbles in the cell culture research field is solved.
また、一般家庭で二酸化炭素微小泡を利用することでいえば、家庭でドライアイスを購入すればよい、としたい、ということの実現である。 In addition, the use of carbon dioxide microbubbles in ordinary homes is the realization that it is desirable to purchase dry ice at home.
本発明の前提として、特許文献１の技術による微小泡を利用することがある。その理由は、特許文献１の技術によって生成される微小泡の粒径は、比較的小さく、生成も安定しており、さまざまな微小泡を利用でその有用性が証明されているからである。少なくともその粒径が３０μｍ以下のマイクロバブルを含むバブル生成が実現できている。 As a premise of the present invention, there are cases where microbubbles by the technique of Patent Document 1 are used. The reason is that the particle size of the microbubbles produced by the technique of Patent Document 1 is relatively small and the production is stable, and its usefulness has been proved by utilizing various microbubbles. Bubble generation including at least microbubbles having a particle size of 30 μm or less can be realized.
ここで重要なのは、科学的説明は現在研究中であるが、「大気圧で気体吸引をなす、渦流ポンプポンプの利用」である。ここで、特許文献４および特許文献５の、「固化ガス（ドライアイス）」の気化の方法をみると、気化ででえられるガスによる微小泡発生についての記述をみれば、気化によって大気圧以上となったガス圧でバブリングさせていることが読み取れる。
What is important here is the use of a vortex pump pump that draws gas at atmospheric pressure, although scientific explanation is currently under study. Here, when the vaporization method of “solidified gas (dry ice)” in
したがって、特許文献１の技術を特許文献４ないしは５の技術に適用できない。
Therefore, the technique of Patent Document 1 cannot be applied to the techniques of
そこで、発明者は、上記の問題（特許文献１の技術を特許文献４ないしは５の技術に適用できない）を次のように解決した。
Therefore, the inventor solved the above problem (the technique of Patent Document 1 cannot be applied to the techniques of
すなわち（図１参照、請求項１）、装置として、気体吸引手段、液体吸引手段、液体吐出手段、および、これらが接続する微小気体を生成する本体手段を具備した微小気泡発生器であって、該微小気泡は、少なくともその粒径が３０μｍ以下のマイクロバブルを含み、前記気体吸引手段に、さらに接続された気相のガス容器（Ｇ）、該Ｇに接続された固化ガス容器または液化ガス容器（ＳＬ）を具備した微小気泡発生器であり、かかる装置が製造する組成物は、気体吸引手段、液体吸引手段、液体吐出手段、および、これらが接続する微小気体を生成する本体手段を具備した微小気泡発生器を用いて製造された微小気泡含有組成物であって、該微小気泡は、少なくともその粒径が３０μｍ以下のマイクロバブルを含み、前記気体吸引手段に、さらに接続された、気相のガス容器（Ｇ）、該Ｇに接続された固化ガス容器または液化ガス容器（ＳＬ）を具備した微小気泡発生器によって、固化ガスまたは液化ガスを気化して微小気泡となし、前記液体吐出手段から該微小気泡を吐出してなる微小気泡含有組成物である。
That is, (see FIG. 1, claim 1 ), as a device, a microbubble generator comprising a gas suction means, a liquid suction means, a liquid discharge means, and a main body means for generating a microgas to which these are connected, The microbubble includes at least a microbubble having a particle size of 30 μm or less. The gas suction means is further connected to a gas phase gas container (G), a solidified gas container or a liquefied gas container connected to the G. (SL) is a microbubble generator, and a composition produced by such a device includes a gas suction means, a liquid suction means, a liquid discharge means, and a main body means for generating a microgas to which these are connected. A microbubble-containing composition produced using a microbubble generator, wherein the microbubble includes at least a microbubble having a particle size of 30 μm or less, and the gas suction means includes: The solid gas or liquefied gas is vaporized by a microbubble generator connected to the gas phase gas container (G), and the solidified gas container or liquefied gas container (SL) connected to the G. It is a composition containing microbubbles formed by forming bubbles and discharging the microbubbles from the liquid discharge means.
また（図１参照、請求項２）、固化ガス容器または液化ガス容器（ＳＬ）を昇温して気化させる手段３、および、気相のガス容器（Ｇ）のガス圧を検知する手段Ｐ、および、該ガス圧を検知する手段の検知圧力に基づいて前記の（ＳＬ）を昇温して固化ガスまたは液化ガスを気化させる手段３に昇温指令を出す気化制御手段Ｐ１、をさらに具備した微小気泡発生器であり、かかる装置が製造する組成物は、固化ガス容器または液化ガス容器（ＳＬ）を昇温して気化させる手段、および、気相のガス容器（Ｇ）のガス圧を検知する手段、および、該ガス圧を検知する手段Ｐの検知圧力に基づいて前記の（ＳＬ）を昇温して固化ガスまたは液化ガスを気化させる手段３に昇温指令を出す気化制御手段Ｐ１、をさらに具備して、気相のガス容器（Ｇ）のガス圧を慨ね大気圧に保持しつつ、前記気体吸引手段に固化ガスまたは液化ガスを気化して吸引させてなる組成物である。
Further, (see FIG. 1, claim 2 ), means 3 for raising the temperature of the solidified gas container or liquefied gas container (SL) to vaporize, and means P for detecting the gas pressure in the gas phase gas container (G), And vaporization control means P1 for issuing a temperature raising command to the
また当然ながら（請求項４）、固化ガスまたは液化ガスは、窒素（Ｎ2）または酸素（Ｏ2）または二酸化炭素（ＣＯ2）である。
Naturally ( claim 4 ), the solidified gas or liquefied gas is nitrogen (N2), oxygen (O2) or carbon dioxide (CO2).
また（請求項３）、装置において、（ＳＬ）を昇温して固化ガスまたは液化ガスを気化させる手段に昇温指令を出す気化制御手段が、たとえば圧力制御弁等を組合せた、気相のガス容器（Ｇ）のガス圧を慨ね大気圧に保持する制御手段であることが、渦流ポンプポンプのバブル生成装置本体に適用する場合に好ましい。 ( Claim 3 ) In the apparatus, the vaporization control means for raising the temperature of (SL) and issuing a temperature raising command to the means for vaporizing the solidified gas or the liquefied gas is, for example, a gas phase control system combined with a pressure control valve . The control means for maintaining the gas pressure of the gas container (G) at atmospheric pressure is preferable when applied to the bubble generating device body of the vortex pump pump.
本発明は、こういった手法の組合わせで次の効果が得られるものである。 In the present invention, the following effects can be obtained by a combination of these methods.
本発明によって、より手軽に微小泡を利用することが実現される。たとえば従来、酸素ボンベ、窒素ボンベ、二酸化炭素ボンベを必要として場所をとるという研究現場の問題を、液化ガスの利用で解消できる。 According to the present invention, it is possible to use microbubbles more easily. For example, the problem of the research site that conventionally requires an oxygen cylinder, a nitrogen cylinder, and a carbon dioxide cylinder can be solved by using liquefied gas.
また、家庭で二酸化炭素微小泡を利用するときに、ドライアイスを購入すればよい、いった簡単な作業でよくなる。 In addition, when using carbon dioxide microbubbles at home, it is easy to purchase dry ice.
図１の固化ガス容器または液化ガス容器１（ＳＬ）、すなわち、ドライアイス容器の模式図の上左部分に描いたように、ドライアイス容器が開閉自在、かつまた、「閉」時に密閉が確保される天蓋状の蓋を具備していることが、実際の利用上好ましい態様である。 As depicted in the upper left part of the solidified gas container or liquefied gas container 1 (SL), that is, the schematic diagram of the dry ice container in FIG. 1, the dry ice container can be freely opened and closed, and hermeticity is ensured when “closed”. It is a preferable aspect for practical use to have a canopy-shaped lid.
１ 固化ガス容器または液化ガス容器（ＳＬ）
２ 気相のガス容器（Ｇ）であって、図示しないが、圧力緩衝タンクを具備している。圧力緩衝タンクには適切な容量調節手段が兼備されており、これらによって気化ガス圧を概ね大気圧に維持する。
３ （ＳＬ）を昇温して固化ガスまたは液化ガスを気化させる手段、および、該気化の制御手段。たとえば、電熱ヒータ、ピアジェ素子温度制御デバイス、ドライアイスの場合には水シャワーや水スプレーでもよい。
４ 気体吸引手段
１０ 微小気泡発生器
１４ １０の液体吸引手段（の先端部分）
１５ １０の液体吐出手段（の先端部分）
Ｐ 気相のガス容器（Ｇ）のガス圧を検知する手段
Ｐ１ Ｐの検知圧力に基づいて（３）に昇温指令を出す気化制御手段
1 Solidified gas container or liquefied gas container (SL)
2 Gas phase gas container (G), which has a pressure buffer tank (not shown). The pressure buffer tank is equipped with appropriate capacity adjusting means, and these maintain the vaporized gas pressure at approximately atmospheric pressure.
3 means for raising the temperature of (SL) to vaporize solidified gas or liquefied gas, and means for controlling the vaporization. For example, in the case of an electric heater, a Piaget element temperature control device, and dry ice, a water shower or water spray may be used.
4 Gas suction means 10
15 10 Liquid discharge means (front end portion thereof)
P Means for detecting gas pressure in gas phase gas container (G)
Vaporization control means for issuing a temperature raising command to (3) based on the detected pressure of P1 P
Claims (4)
これらが接続する微小気体を生成する本体手段を具備した微小気泡発生器であって、
該微小気泡は、少なくともその粒径が３０μｍ以下のマイクロバブルを含み、
前記気体吸引手段に、さらに接続された気相のガス容器（Ｇ）、
該Ｇに接続された固化ガス容器または液化ガス容器（ＳＬ）を具備した微小気泡発生器。 A microbubble generator comprising a gas suction means, a liquid suction means, a liquid discharge means, and a main body means for generating a microgas to which these are connected,
The microbubbles include at least microbubbles having a particle size of 30 μm or less,
A gas phase gas container (G) further connected to the gas suction means,
A microbubble generator comprising a solidified gas container or a liquefied gas container (SL) connected to the G.
固化ガス容器または液化ガス容器（ＳＬ）を昇温して気化させる手段、および、
気相のガス容器（Ｇ）のガス圧を検知する手段、および、
該ガス圧を検知する手段の検知圧力に基づいて
前記の（ＳＬ）を昇温して固化ガスまたは液化ガスを気化させる手段に昇温指令を出す気化制御手段、
をさらに具備した微小気泡発生器。 The microbubble generator of claim 1 ,
Means for raising the temperature of the solidified gas container or the liquefied gas container (SL) to vaporize; and
Means for detecting the gas pressure of the gas phase gas container (G), and
A vaporization control means for raising the temperature of the (SL) based on a detection pressure of the means for detecting the gas pressure and issuing a temperature increase command to the means for vaporizing the solidified gas or the liquefied gas;
A microbubble generator further comprising:
（ＳＬ）を昇温して固化ガスまたは液化ガスを気化させる手段に昇温指令を出す気化制御手段が、
気相のガス容器（Ｇ）のガス圧を慨ね大気圧に保持する制御である微小気泡発生器。 The microbubble generator of claim 2 ,
A vaporization control means for issuing a temperature elevation command to the means for raising the temperature of (SL) to vaporize the solidified gas or the liquefied gas;
A microbubble generator that controls the gas pressure in the gas phase gas container (G) to maintain the atmospheric pressure.
固化ガスまたは液化ガスが、
窒素（Ｎ2）または酸素（Ｏ2）または二酸化炭素（ＣＯ2）である微小気泡発生器。
In the microbubble generator in any one of Claims 1-3 ,
Solidified or liquefied gas
A microbubble generator that is nitrogen (N2) or oxygen (O2) or carbon dioxide (CO2).
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| JPS6018633B2 (en) * | 1983-04-25 | 1985-05-11 | 北国農機株式会社 | Dry ice white smoke generator |
| JPS6483663A (en) * | 1987-09-25 | 1989-03-29 | Furukawa Electric Co Ltd | Liquid raw material evaporating device |
| JP2005245990A (en) * | 2004-03-02 | 2005-09-15 | Hikari Sozo Kenkyusho:Kk | Medical treatment and health promotion apparatus for carbonate spring effect using dry ice |
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